-- dump date 20140619_012216 -- class Genbank::misc_feature -- table misc_feature_note -- id note 482957000001 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957000002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000003 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957000004 dimerization interface [polypeptide binding]; other site 482957000005 substrate binding pocket [chemical binding]; other site 482957000006 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 482957000007 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 482957000008 GDP-binding site [chemical binding]; other site 482957000009 ACT binding site; other site 482957000010 IMP binding site; other site 482957000011 transcriptional regulator; Provisional; Region: PRK10632 482957000012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000013 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957000014 putative effector binding pocket; other site 482957000015 dimerization interface [polypeptide binding]; other site 482957000016 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957000017 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957000018 substrate binding pocket [chemical binding]; other site 482957000019 membrane-bound complex binding site; other site 482957000020 hinge residues; other site 482957000021 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 482957000022 amidohydrolase; Region: amidohydrolases; TIGR01891 482957000023 putative metal binding site [ion binding]; other site 482957000024 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957000025 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957000026 trimer interface [polypeptide binding]; other site 482957000027 eyelet of channel; other site 482957000028 citrate-proton symporter; Provisional; Region: PRK15075 482957000029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957000030 putative substrate translocation pore; other site 482957000031 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 482957000032 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 482957000033 WYL domain; Region: WYL; pfam13280 482957000034 Response regulator receiver domain; Region: Response_reg; pfam00072 482957000035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957000036 active site 482957000037 phosphorylation site [posttranslational modification] 482957000038 intermolecular recognition site; other site 482957000039 dimerization interface [polypeptide binding]; other site 482957000040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957000041 non-specific DNA binding site [nucleotide binding]; other site 482957000042 salt bridge; other site 482957000043 sequence-specific DNA binding site [nucleotide binding]; other site 482957000044 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957000045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957000046 non-specific DNA binding site [nucleotide binding]; other site 482957000047 salt bridge; other site 482957000048 sequence-specific DNA binding site [nucleotide binding]; other site 482957000049 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 482957000050 Integrase core domain; Region: rve; pfam00665 482957000051 Bacterial TniB protein; Region: TniB; pfam05621 482957000052 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 482957000053 TniQ; Region: TniQ; pfam06527 482957000054 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 482957000055 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 482957000056 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 482957000057 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957000058 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957000059 Cytochrome c; Region: Cytochrom_C; pfam00034 482957000060 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 482957000061 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957000062 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 482957000063 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 482957000064 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 482957000065 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 482957000066 multidrug resistance protein MdtN; Provisional; Region: PRK10476 482957000067 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957000068 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957000069 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 482957000070 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 482957000071 MarR family; Region: MarR_2; cl17246 482957000072 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957000073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000075 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957000076 putative effector binding pocket; other site 482957000077 dimerization interface [polypeptide binding]; other site 482957000078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000080 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957000081 putative effector binding pocket; other site 482957000082 dimerization interface [polypeptide binding]; other site 482957000083 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957000084 dimerization interface [polypeptide binding]; other site 482957000085 putative DNA binding site [nucleotide binding]; other site 482957000086 putative Zn2+ binding site [ion binding]; other site 482957000087 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 482957000088 Low molecular weight phosphatase family; Region: LMWPc; cd00115 482957000089 active site 482957000090 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 482957000091 arsenical-resistance protein; Region: acr3; TIGR00832 482957000092 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 482957000093 ArsC family; Region: ArsC; pfam03960 482957000094 catalytic residues [active] 482957000095 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 482957000096 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957000097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957000098 Coenzyme A binding pocket [chemical binding]; other site 482957000099 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957000100 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 482957000101 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 482957000102 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 482957000103 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 482957000104 Cl- selectivity filter; other site 482957000105 Cl- binding residues [ion binding]; other site 482957000106 pore gating glutamate residue; other site 482957000107 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 482957000108 dimer interface [polypeptide binding]; other site 482957000109 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 482957000110 putative outer membrane lipoprotein; Provisional; Region: PRK09967 482957000111 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957000112 ligand binding site [chemical binding]; other site 482957000113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957000114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957000115 putative substrate translocation pore; other site 482957000116 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 482957000117 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 482957000118 putative ion selectivity filter; other site 482957000119 putative pore gating glutamate residue; other site 482957000120 putative H+/Cl- coupling transport residue; other site 482957000121 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 482957000122 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 482957000123 Ferritin-like domain; Region: Ferritin_2; pfam13668 482957000124 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 482957000125 Fasciclin domain; Region: Fasciclin; pfam02469 482957000126 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957000127 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957000128 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 482957000129 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 482957000130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957000131 S-adenosylmethionine binding site [chemical binding]; other site 482957000132 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 482957000133 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 482957000134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957000135 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 482957000136 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 482957000137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957000138 S-adenosylmethionine binding site [chemical binding]; other site 482957000139 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 482957000140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 482957000141 Anti-sigma-K factor rskA; Region: RskA; pfam10099 482957000142 RNA polymerase sigma factor; Provisional; Region: PRK12514 482957000143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957000144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957000145 DNA binding residues [nucleotide binding] 482957000146 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 482957000147 active site clefts [active] 482957000148 zinc binding site [ion binding]; other site 482957000149 dimer interface [polypeptide binding]; other site 482957000150 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 482957000151 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 482957000152 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 482957000153 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 482957000154 trimer interface [polypeptide binding]; other site 482957000155 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 482957000156 YadA-like C-terminal region; Region: YadA; pfam03895 482957000157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957000158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957000159 active site 482957000160 phosphorylation site [posttranslational modification] 482957000161 intermolecular recognition site; other site 482957000162 dimerization interface [polypeptide binding]; other site 482957000163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957000164 DNA binding site [nucleotide binding] 482957000165 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957000166 ligand binding site [chemical binding]; other site 482957000167 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 482957000168 AAA domain; Region: AAA_13; pfam13166 482957000169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957000170 ABC transporter signature motif; other site 482957000171 Walker B; other site 482957000172 D-loop; other site 482957000173 H-loop/switch region; other site 482957000174 H-NS histone family; Region: Histone_HNS; pfam00816 482957000175 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957000176 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 482957000177 Restriction endonuclease; Region: Mrr_cat; pfam04471 482957000178 Uncharacterized conserved protein [Function unknown]; Region: COG4933 482957000179 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 482957000180 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 482957000181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000182 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957000183 dimerization interface [polypeptide binding]; other site 482957000184 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 482957000185 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957000186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957000190 dimerization interface [polypeptide binding]; other site 482957000191 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 482957000192 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957000193 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957000194 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 482957000195 Protein export membrane protein; Region: SecD_SecF; cl14618 482957000196 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957000197 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 482957000198 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957000199 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957000200 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957000201 conserved cys residue [active] 482957000202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000204 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 482957000205 Zn2+ binding site [ion binding]; other site 482957000206 Mg2+ binding site [ion binding]; other site 482957000207 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 482957000208 transcriptional regulator MerD; Provisional; Region: PRK13749 482957000209 DNA binding residues [nucleotide binding] 482957000210 putative dimer interface [polypeptide binding]; other site 482957000211 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957000212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957000213 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 482957000214 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 482957000215 RES domain; Region: RES; pfam08808 482957000216 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 482957000217 active site 482957000218 Int/Topo IB signature motif; other site 482957000219 catalytic residues [active] 482957000220 DNA binding site [nucleotide binding] 482957000221 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 482957000222 xanthine permease; Region: pbuX; TIGR03173 482957000223 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 482957000224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957000227 dimerization interface [polypeptide binding]; other site 482957000228 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 482957000229 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 482957000230 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 482957000231 transcriptional regulator; Provisional; Region: PRK10632 482957000232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000233 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957000234 putative effector binding pocket; other site 482957000235 dimerization interface [polypeptide binding]; other site 482957000236 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 482957000237 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 482957000238 Uncharacterized protein family (UPF0167); Region: UPF0167; pfam03691 482957000239 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 482957000240 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 482957000241 active site 482957000242 metal binding site [ion binding]; metal-binding site 482957000243 DNA binding site [nucleotide binding] 482957000244 P-loop containing region of AAA domain; Region: AAA_29; cl17516 482957000245 AAA domain; Region: AAA_27; pfam13514 482957000246 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 482957000247 HD domain; Region: HD_4; pfam13328 482957000248 Protein of unknown function (DUF429); Region: DUF429; pfam04250 482957000249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957000250 S-adenosylmethionine binding site [chemical binding]; other site 482957000251 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 482957000252 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 482957000253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957000254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957000255 DNA binding residues [nucleotide binding] 482957000256 Cache domain; Region: Cache_1; pfam02743 482957000257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957000258 dimerization interface [polypeptide binding]; other site 482957000259 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957000260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957000261 dimer interface [polypeptide binding]; other site 482957000262 putative CheW interface [polypeptide binding]; other site 482957000263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957000264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957000265 Coenzyme A binding pocket [chemical binding]; other site 482957000266 SnoaL-like domain; Region: SnoaL_3; pfam13474 482957000267 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957000268 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 482957000269 NAD(P) binding site [chemical binding]; other site 482957000270 catalytic residues [active] 482957000271 putative aminotransferase; Provisional; Region: PRK12403 482957000272 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957000273 inhibitor-cofactor binding pocket; inhibition site 482957000274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957000275 catalytic residue [active] 482957000276 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 482957000277 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957000278 Na binding site [ion binding]; other site 482957000279 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957000280 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957000281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000282 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 482957000283 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 482957000284 active site 482957000285 acyl-activating enzyme (AAE) consensus motif; other site 482957000286 putative CoA binding site [chemical binding]; other site 482957000287 AMP binding site [chemical binding]; other site 482957000288 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 482957000289 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 482957000290 NAD binding site [chemical binding]; other site 482957000291 homodimer interface [polypeptide binding]; other site 482957000292 homotetramer interface [polypeptide binding]; other site 482957000293 active site 482957000294 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 482957000295 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957000296 dimer interface [polypeptide binding]; other site 482957000297 active site 482957000298 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 482957000299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000300 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 482957000301 allantoate amidohydrolase; Reviewed; Region: PRK12893 482957000302 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 482957000303 active site 482957000304 metal binding site [ion binding]; metal-binding site 482957000305 dimer interface [polypeptide binding]; other site 482957000306 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 482957000307 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 482957000308 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 482957000309 homodimer interface [polypeptide binding]; other site 482957000310 active site 482957000311 FMN binding site [chemical binding]; other site 482957000312 substrate binding site [chemical binding]; other site 482957000313 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 482957000314 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 482957000315 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957000316 Na binding site [ion binding]; other site 482957000317 putative substrate binding site [chemical binding]; other site 482957000318 phenylhydantoinase; Validated; Region: PRK08323 482957000319 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 482957000320 tetramer interface [polypeptide binding]; other site 482957000321 active site 482957000322 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 482957000323 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 482957000324 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 482957000325 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 482957000326 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 482957000327 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 482957000328 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 482957000329 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 482957000330 active site 482957000331 catalytic motif [active] 482957000332 Zn binding site [ion binding]; other site 482957000333 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957000334 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957000335 [2Fe-2S] cluster binding site [ion binding]; other site 482957000336 methionine sulfoxide reductase A; Provisional; Region: PRK13014 482957000337 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 482957000338 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 482957000339 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 482957000340 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957000341 catalytic residues [active] 482957000342 methionine sulfoxide reductase B; Provisional; Region: PRK00222 482957000343 SelR domain; Region: SelR; pfam01641 482957000344 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957000345 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957000346 trimer interface [polypeptide binding]; other site 482957000347 eyelet of channel; other site 482957000348 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 482957000349 Na binding site [ion binding]; other site 482957000350 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 482957000351 amidase; Provisional; Region: PRK07487 482957000352 Amidase; Region: Amidase; cl11426 482957000353 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 482957000354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957000356 dimerization interface [polypeptide binding]; other site 482957000357 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 482957000358 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957000359 Ferritin-like; Region: Ferritin-like; pfam12902 482957000360 quinohemoprotein amine dehydrogenase maturation protein; Region: quino_hemo_SAM; TIGR03906 482957000361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957000362 FeS/SAM binding site; other site 482957000363 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 482957000364 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 482957000365 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957000366 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 482957000367 nudix motif; other site 482957000368 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 482957000369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957000370 substrate binding pocket [chemical binding]; other site 482957000371 membrane-bound complex binding site; other site 482957000372 hinge residues; other site 482957000373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957000375 dimerization interface [polypeptide binding]; other site 482957000376 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 482957000377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957000378 active site 482957000379 phosphorylation site [posttranslational modification] 482957000380 intermolecular recognition site; other site 482957000381 dimerization interface [polypeptide binding]; other site 482957000382 LytTr DNA-binding domain; Region: LytTR; smart00850 482957000383 Histidine kinase; Region: His_kinase; pfam06580 482957000384 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 482957000385 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 482957000386 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 482957000387 Walker A/P-loop; other site 482957000388 ATP binding site [chemical binding]; other site 482957000389 Q-loop/lid; other site 482957000390 ABC transporter signature motif; other site 482957000391 Walker B; other site 482957000392 D-loop; other site 482957000393 H-loop/switch region; other site 482957000394 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 482957000395 active site 2 [active] 482957000396 active site 1 [active] 482957000397 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957000398 classical (c) SDRs; Region: SDR_c; cd05233 482957000399 NAD(P) binding site [chemical binding]; other site 482957000400 active site 482957000401 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 482957000402 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 482957000403 active site 482957000404 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 482957000405 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 482957000406 dimer interface [polypeptide binding]; other site 482957000407 active site 482957000408 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 482957000409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957000410 acyl-activating enzyme (AAE) consensus motif; other site 482957000411 AMP binding site [chemical binding]; other site 482957000412 active site 482957000413 CoA binding site [chemical binding]; other site 482957000414 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 482957000415 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 482957000416 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 482957000417 Methyltransferase domain; Region: Methyltransf_31; pfam13847 482957000418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957000419 S-adenosylmethionine binding site [chemical binding]; other site 482957000420 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 482957000421 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 482957000422 citrylCoA binding site [chemical binding]; other site 482957000423 oxalacetate binding site [chemical binding]; other site 482957000424 coenzyme A binding site [chemical binding]; other site 482957000425 catalytic triad [active] 482957000426 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957000427 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957000428 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 482957000429 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 482957000430 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 482957000431 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957000432 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 482957000433 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957000434 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 482957000435 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 482957000436 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 482957000437 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957000438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000439 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957000440 substrate binding pocket [chemical binding]; other site 482957000441 dimerization interface [polypeptide binding]; other site 482957000442 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 482957000443 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957000444 Walker A/P-loop; other site 482957000445 ATP binding site [chemical binding]; other site 482957000446 Q-loop/lid; other site 482957000447 ABC transporter signature motif; other site 482957000448 Walker B; other site 482957000449 D-loop; other site 482957000450 H-loop/switch region; other site 482957000451 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957000453 dimer interface [polypeptide binding]; other site 482957000454 conserved gate region; other site 482957000455 putative PBP binding loops; other site 482957000456 ABC-ATPase subunit interface; other site 482957000457 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957000458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957000459 dimer interface [polypeptide binding]; other site 482957000460 conserved gate region; other site 482957000461 putative PBP binding loops; other site 482957000462 ABC-ATPase subunit interface; other site 482957000463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957000464 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957000465 substrate binding pocket [chemical binding]; other site 482957000466 membrane-bound complex binding site; other site 482957000467 hinge residues; other site 482957000468 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 482957000469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957000470 Walker A/P-loop; other site 482957000471 ATP binding site [chemical binding]; other site 482957000472 Q-loop/lid; other site 482957000473 ABC transporter signature motif; other site 482957000474 Walker B; other site 482957000475 D-loop; other site 482957000476 H-loop/switch region; other site 482957000477 TOBE domain; Region: TOBE; pfam03459 482957000478 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957000479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957000480 dimer interface [polypeptide binding]; other site 482957000481 conserved gate region; other site 482957000482 putative PBP binding loops; other site 482957000483 ABC-ATPase subunit interface; other site 482957000484 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 482957000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957000486 dimer interface [polypeptide binding]; other site 482957000487 conserved gate region; other site 482957000488 putative PBP binding loops; other site 482957000489 ABC-ATPase subunit interface; other site 482957000490 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 482957000491 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957000492 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957000493 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 482957000494 NAD(P) binding site [chemical binding]; other site 482957000495 catalytic residues [active] 482957000496 catalytic residues [active] 482957000497 hypothetical protein; Provisional; Region: PRK07524 482957000498 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957000499 PYR/PP interface [polypeptide binding]; other site 482957000500 dimer interface [polypeptide binding]; other site 482957000501 TPP binding site [chemical binding]; other site 482957000502 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957000503 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 482957000504 TPP-binding site [chemical binding]; other site 482957000505 Double zinc ribbon; Region: DZR; pfam12773 482957000506 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 482957000507 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 482957000508 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 482957000509 cyclase homology domain; Region: CHD; cd07302 482957000510 nucleotidyl binding site; other site 482957000511 metal binding site [ion binding]; metal-binding site 482957000512 dimer interface [polypeptide binding]; other site 482957000513 AAA ATPase domain; Region: AAA_16; pfam13191 482957000514 Predicted ATPase [General function prediction only]; Region: COG3903 482957000515 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 482957000516 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 482957000517 active site 482957000518 nucleophile elbow; other site 482957000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 482957000520 Chitin binding domain; Region: Chitin_bind_3; pfam03067 482957000521 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957000522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957000523 metal binding site [ion binding]; metal-binding site 482957000524 active site 482957000525 I-site; other site 482957000526 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 482957000527 active site 482957000528 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957000529 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 482957000530 putative di-iron ligands [ion binding]; other site 482957000531 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 482957000532 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 482957000533 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957000534 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957000535 trimer interface [polypeptide binding]; other site 482957000536 eyelet of channel; other site 482957000537 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 482957000538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 482957000539 enoyl-CoA hydratase; Provisional; Region: PRK06688 482957000540 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957000541 substrate binding site [chemical binding]; other site 482957000542 oxyanion hole (OAH) forming residues; other site 482957000543 trimer interface [polypeptide binding]; other site 482957000544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 482957000545 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 482957000546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957000547 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 482957000548 acyl-activating enzyme (AAE) consensus motif; other site 482957000549 acyl-activating enzyme (AAE) consensus motif; other site 482957000550 putative AMP binding site [chemical binding]; other site 482957000551 putative active site [active] 482957000552 putative CoA binding site [chemical binding]; other site 482957000553 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957000554 classical (c) SDRs; Region: SDR_c; cd05233 482957000555 NAD(P) binding site [chemical binding]; other site 482957000556 active site 482957000557 enoyl-CoA hydratase; Provisional; Region: PRK08252 482957000558 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957000559 substrate binding site [chemical binding]; other site 482957000560 oxyanion hole (OAH) forming residues; other site 482957000561 trimer interface [polypeptide binding]; other site 482957000562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 482957000563 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 482957000564 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957000565 FMN binding site [chemical binding]; other site 482957000566 substrate binding site [chemical binding]; other site 482957000567 putative catalytic residue [active] 482957000568 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957000569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957000570 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957000571 DUF35 OB-fold domain; Region: DUF35; pfam01796 482957000572 lipid-transfer protein; Provisional; Region: PRK08256 482957000573 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 482957000574 active site 482957000575 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957000576 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957000577 NAD(P) binding site [chemical binding]; other site 482957000578 catalytic residues [active] 482957000579 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 482957000580 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 482957000581 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957000582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957000583 DNA binding residues [nucleotide binding] 482957000584 dimerization interface [polypeptide binding]; other site 482957000585 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957000586 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957000587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000588 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957000589 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 482957000590 NAD(P) binding site [chemical binding]; other site 482957000591 catalytic residues [active] 482957000592 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957000593 classical (c) SDRs; Region: SDR_c; cd05233 482957000594 NAD(P) binding site [chemical binding]; other site 482957000595 active site 482957000596 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 482957000597 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 482957000598 Cupin; Region: Cupin_6; pfam12852 482957000599 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957000600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000601 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 482957000602 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957000603 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957000604 [2Fe-2S] cluster binding site [ion binding]; other site 482957000605 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 482957000606 alpha subunit interface [polypeptide binding]; other site 482957000607 active site 482957000608 substrate binding site [chemical binding]; other site 482957000609 Fe binding site [ion binding]; other site 482957000610 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957000611 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 482957000612 FMN-binding pocket [chemical binding]; other site 482957000613 flavin binding motif; other site 482957000614 phosphate binding motif [ion binding]; other site 482957000615 beta-alpha-beta structure motif; other site 482957000616 NAD binding pocket [chemical binding]; other site 482957000617 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957000618 catalytic loop [active] 482957000619 iron binding site [ion binding]; other site 482957000620 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 482957000621 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957000622 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957000623 trimer interface [polypeptide binding]; other site 482957000624 eyelet of channel; other site 482957000625 recombination factor protein RarA; Reviewed; Region: PRK13342 482957000626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957000627 Walker A motif; other site 482957000628 ATP binding site [chemical binding]; other site 482957000629 Walker B motif; other site 482957000630 arginine finger; other site 482957000631 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 482957000632 MG2 domain; Region: A2M_N; pfam01835 482957000633 Double zinc ribbon; Region: DZR; pfam12773 482957000634 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 482957000635 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 482957000636 succinic semialdehyde dehydrogenase; Region: PLN02278 482957000637 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 482957000638 tetramerization interface [polypeptide binding]; other site 482957000639 NAD(P) binding site [chemical binding]; other site 482957000640 catalytic residues [active] 482957000641 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 482957000642 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 482957000643 putative active site [active] 482957000644 metal binding site [ion binding]; metal-binding site 482957000645 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957000646 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957000647 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957000648 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957000649 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957000650 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957000651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957000652 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 482957000653 NAD binding site [chemical binding]; other site 482957000654 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957000655 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957000656 substrate binding pocket [chemical binding]; other site 482957000657 choline dehydrogenase; Validated; Region: PRK02106 482957000658 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957000659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957000660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957000661 active site 482957000662 phosphorylation site [posttranslational modification] 482957000663 intermolecular recognition site; other site 482957000664 dimerization interface [polypeptide binding]; other site 482957000665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957000666 DNA binding site [nucleotide binding] 482957000667 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 482957000668 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 482957000669 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 482957000670 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 482957000671 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 482957000672 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 482957000673 homodimer interface [polypeptide binding]; other site 482957000674 substrate-cofactor binding pocket; other site 482957000675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957000676 catalytic residue [active] 482957000677 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 482957000678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957000679 NAD binding site [chemical binding]; other site 482957000680 catalytic residues [active] 482957000681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957000682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957000684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000685 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957000686 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 482957000687 NAD(P) binding pocket [chemical binding]; other site 482957000688 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 482957000689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957000690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957000691 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957000692 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 482957000693 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957000694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957000695 catalytic residue [active] 482957000696 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 482957000697 Low affinity iron permease; Region: Iron_permease; pfam04120 482957000698 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 482957000699 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 482957000700 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 482957000701 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 482957000702 acyl-activating enzyme (AAE) consensus motif; other site 482957000703 putative AMP binding site [chemical binding]; other site 482957000704 putative active site [active] 482957000705 putative CoA binding site [chemical binding]; other site 482957000706 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 482957000707 active site 482957000708 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 482957000709 Cytochrome P450; Region: p450; pfam00067 482957000710 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 482957000711 Flavodoxin; Region: Flavodoxin_1; pfam00258 482957000712 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 482957000713 FAD binding pocket [chemical binding]; other site 482957000714 FAD binding motif [chemical binding]; other site 482957000715 catalytic residues [active] 482957000716 NAD binding pocket [chemical binding]; other site 482957000717 phosphate binding motif [ion binding]; other site 482957000718 beta-alpha-beta structure motif; other site 482957000719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957000720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957000722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000723 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957000724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957000725 active site 482957000726 phosphorylation site [posttranslational modification] 482957000727 intermolecular recognition site; other site 482957000728 dimerization interface [polypeptide binding]; other site 482957000729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957000730 DNA binding site [nucleotide binding] 482957000731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957000732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957000733 dimer interface [polypeptide binding]; other site 482957000734 phosphorylation site [posttranslational modification] 482957000735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957000736 ATP binding site [chemical binding]; other site 482957000737 Mg2+ binding site [ion binding]; other site 482957000738 G-X-G motif; other site 482957000739 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957000740 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957000741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000742 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957000743 Uncharacterized conserved protein [Function unknown]; Region: COG2128 482957000744 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 482957000745 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 482957000746 acyl-activating enzyme (AAE) consensus motif; other site 482957000747 putative AMP binding site [chemical binding]; other site 482957000748 putative active site [active] 482957000749 putative CoA binding site [chemical binding]; other site 482957000750 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957000751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957000752 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957000753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 482957000755 Protein of unknown function (DUF330); Region: DUF330; pfam03886 482957000756 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 482957000757 mce related protein; Region: MCE; pfam02470 482957000758 mce related protein; Region: MCE; pfam02470 482957000759 mce related protein; Region: MCE; pfam02470 482957000760 Paraquat-inducible protein A; Region: PqiA; pfam04403 482957000761 Paraquat-inducible protein A; Region: PqiA; pfam04403 482957000762 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 482957000763 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 482957000764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957000765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957000766 active site 482957000767 phosphorylation site [posttranslational modification] 482957000768 intermolecular recognition site; other site 482957000769 dimerization interface [polypeptide binding]; other site 482957000770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957000771 DNA binding site [nucleotide binding] 482957000772 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957000773 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 482957000774 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 482957000775 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957000776 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957000777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957000778 HAMP domain; Region: HAMP; pfam00672 482957000779 dimerization interface [polypeptide binding]; other site 482957000780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957000781 dimer interface [polypeptide binding]; other site 482957000782 phosphorylation site [posttranslational modification] 482957000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957000784 Mg2+ binding site [ion binding]; other site 482957000785 G-X-G motif; other site 482957000786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000788 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 482957000789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957000790 Cytochrome c; Region: Cytochrom_C; cl11414 482957000791 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957000792 Cytochrome c; Region: Cytochrom_C; cl11414 482957000793 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 482957000794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000795 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 482957000796 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 482957000797 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 482957000798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957000799 Cytochrome c553 [Energy production and conversion]; Region: COG2863 482957000800 Cytochrome c; Region: Cytochrom_C; cl11414 482957000801 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 482957000802 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 482957000803 homotrimer interaction site [polypeptide binding]; other site 482957000804 putative active site [active] 482957000805 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 482957000806 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 482957000807 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 482957000808 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 482957000809 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957000810 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957000811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957000812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000813 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 482957000814 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 482957000815 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 482957000816 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957000817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957000818 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957000819 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 482957000820 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 482957000821 NAD(P) binding site [chemical binding]; other site 482957000822 catalytic residues [active] 482957000823 choline dehydrogenase; Validated; Region: PRK02106 482957000824 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957000825 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 482957000826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957000827 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 482957000828 acyl-activating enzyme (AAE) consensus motif; other site 482957000829 putative AMP binding site [chemical binding]; other site 482957000830 putative active site [active] 482957000831 putative CoA binding site [chemical binding]; other site 482957000832 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 482957000833 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957000834 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 482957000835 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957000836 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 482957000837 Fusaric acid resistance protein family; Region: FUSC; pfam04632 482957000838 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 482957000839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000841 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 482957000842 putative substrate binding pocket [chemical binding]; other site 482957000843 putative dimerization interface [polypeptide binding]; other site 482957000844 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 482957000845 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957000846 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 482957000847 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 482957000848 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 482957000849 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 482957000850 putative active site; other site 482957000851 catalytic residue [active] 482957000852 3-dehydroquinate synthase; Provisional; Region: PRK02290 482957000853 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 482957000854 3-dehydroquinate synthase; Provisional; Region: PRK02290 482957000855 O-methyltransferase; Region: Methyltransf_2; pfam00891 482957000856 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957000857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957000858 DNA-binding site [nucleotide binding]; DNA binding site 482957000859 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957000860 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 482957000861 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957000862 N-terminal plug; other site 482957000863 ligand-binding site [chemical binding]; other site 482957000864 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 482957000865 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957000866 D-cysteine desulfhydrase; Validated; Region: PRK03910 482957000867 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 482957000868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957000869 catalytic residue [active] 482957000870 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 482957000871 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 482957000872 ATP-grasp domain; Region: ATP-grasp_4; cl17255 482957000873 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000874 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000875 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 482957000876 putative dimerization interface [polypeptide binding]; other site 482957000877 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 482957000878 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 482957000879 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957000880 active site 482957000881 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 482957000882 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 482957000883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957000884 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 482957000885 beta-ketothiolase; Provisional; Region: PRK09051 482957000886 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957000887 dimer interface [polypeptide binding]; other site 482957000888 active site 482957000889 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 482957000890 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957000891 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957000892 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 482957000893 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 482957000894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957000895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000896 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 482957000897 putative substrate binding pocket [chemical binding]; other site 482957000898 dimerization interface [polypeptide binding]; other site 482957000899 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 482957000900 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 482957000901 putative [Fe4-S4] binding site [ion binding]; other site 482957000902 putative molybdopterin cofactor binding site [chemical binding]; other site 482957000903 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 482957000904 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 482957000905 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 482957000906 putative molybdopterin cofactor binding site; other site 482957000907 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 482957000908 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957000909 FAD binding pocket [chemical binding]; other site 482957000910 FAD binding motif [chemical binding]; other site 482957000911 phosphate binding motif [ion binding]; other site 482957000912 beta-alpha-beta structure motif; other site 482957000913 NAD binding pocket [chemical binding]; other site 482957000914 Heme binding pocket [chemical binding]; other site 482957000915 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 482957000916 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957000917 catalytic loop [active] 482957000918 iron binding site [ion binding]; other site 482957000919 ornithine cyclodeaminase; Validated; Region: PRK06141 482957000920 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 482957000921 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 482957000922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957000923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957000924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957000925 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 482957000926 NAD(P) binding site [chemical binding]; other site 482957000927 active site 482957000928 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 482957000929 Cupin domain; Region: Cupin_2; cl17218 482957000930 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957000931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957000933 EamA-like transporter family; Region: EamA; pfam00892 482957000934 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 482957000935 EamA-like transporter family; Region: EamA; pfam00892 482957000936 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 482957000937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957000938 Walker A motif; other site 482957000939 ATP binding site [chemical binding]; other site 482957000940 Walker B motif; other site 482957000941 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 482957000942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957000943 putative DNA binding site [nucleotide binding]; other site 482957000944 dimerization interface [polypeptide binding]; other site 482957000945 putative Zn2+ binding site [ion binding]; other site 482957000946 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957000947 transcriptional regulator; Provisional; Region: PRK10632 482957000948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957000949 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 482957000950 putative effector binding pocket; other site 482957000951 putative dimerization interface [polypeptide binding]; other site 482957000952 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957000953 Sel1-like repeats; Region: SEL1; smart00671 482957000954 Sel1-like repeats; Region: SEL1; smart00671 482957000955 Sel1-like repeats; Region: SEL1; smart00671 482957000956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957000957 NAD(P) binding site [chemical binding]; other site 482957000958 active site 482957000959 acyl-CoA synthetase; Provisional; Region: PRK13382 482957000960 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957000961 acyl-activating enzyme (AAE) consensus motif; other site 482957000962 AMP binding site [chemical binding]; other site 482957000963 active site 482957000964 CoA binding site [chemical binding]; other site 482957000965 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 482957000966 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 482957000967 intersubunit interface [polypeptide binding]; other site 482957000968 active site 482957000969 catalytic residue [active] 482957000970 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 482957000971 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 482957000972 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 482957000973 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 482957000974 active site 482957000975 catalytic residues [active] 482957000976 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 482957000977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957000978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957000979 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957000980 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 482957000981 substrate binding site [chemical binding]; other site 482957000982 dimer interface [polypeptide binding]; other site 482957000983 ATP binding site [chemical binding]; other site 482957000984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 482957000985 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 482957000986 Restriction endonuclease; Region: Mrr_cat; pfam04471 482957000987 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 482957000988 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 482957000989 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 482957000990 C-terminal domain interface [polypeptide binding]; other site 482957000991 sugar binding site [chemical binding]; other site 482957000992 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 482957000993 homotrimer interaction site [polypeptide binding]; other site 482957000994 putative active site [active] 482957000995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957000996 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957000997 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 482957000998 putative active site [active] 482957000999 putative CoA binding site [chemical binding]; other site 482957001000 nudix motif; other site 482957001001 metal binding site [ion binding]; metal-binding site 482957001002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957001004 putative substrate translocation pore; other site 482957001005 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 482957001006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957001008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001009 short chain dehydrogenase; Provisional; Region: PRK06180 482957001010 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957001011 NADP binding site [chemical binding]; other site 482957001012 active site 482957001013 steroid binding site; other site 482957001014 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957001015 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957001016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957001017 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957001018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957001020 dimerization interface [polypeptide binding]; other site 482957001021 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957001022 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 482957001023 putative active site pocket [active] 482957001024 dimerization interface [polypeptide binding]; other site 482957001025 putative catalytic residue [active] 482957001026 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 482957001027 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957001028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001029 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957001030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957001031 Coenzyme A binding pocket [chemical binding]; other site 482957001032 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 482957001033 EamA-like transporter family; Region: EamA; pfam00892 482957001034 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 482957001035 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 482957001036 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957001037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957001038 putative PBP binding loops; other site 482957001039 dimer interface [polypeptide binding]; other site 482957001040 ABC-ATPase subunit interface; other site 482957001041 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 482957001042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957001043 dimer interface [polypeptide binding]; other site 482957001044 conserved gate region; other site 482957001045 putative PBP binding loops; other site 482957001046 ABC-ATPase subunit interface; other site 482957001047 classical (c) SDRs; Region: SDR_c; cd05233 482957001048 NAD(P) binding site [chemical binding]; other site 482957001049 active site 482957001050 galactonate dehydratase; Provisional; Region: PRK14017 482957001051 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 482957001052 metal binding site [ion binding]; metal-binding site 482957001053 substrate binding pocket [chemical binding]; other site 482957001054 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 482957001055 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 482957001056 Walker A/P-loop; other site 482957001057 ATP binding site [chemical binding]; other site 482957001058 Q-loop/lid; other site 482957001059 ABC transporter signature motif; other site 482957001060 Walker B; other site 482957001061 D-loop; other site 482957001062 H-loop/switch region; other site 482957001063 TOBE domain; Region: TOBE_2; pfam08402 482957001064 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 482957001065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957001066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957001067 DNA binding site [nucleotide binding] 482957001068 domain linker motif; other site 482957001069 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 482957001070 ligand binding site [chemical binding]; other site 482957001071 dimerization interface [polypeptide binding]; other site 482957001072 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957001073 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957001074 trimer interface [polypeptide binding]; other site 482957001075 eyelet of channel; other site 482957001076 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 482957001077 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 482957001078 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 482957001079 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957001080 Ligand Binding Site [chemical binding]; other site 482957001081 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 482957001082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957001083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 482957001084 binding surface 482957001085 TPR motif; other site 482957001086 Phage integrase protein; Region: DUF3701; pfam12482 482957001087 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 482957001088 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 482957001089 Int/Topo IB signature motif; other site 482957001090 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 482957001091 conserved cys residue [active] 482957001092 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957001093 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957001094 conserved cys residue [active] 482957001095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001097 TfoX N-terminal domain; Region: TfoX_N; pfam04993 482957001098 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 482957001099 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957001100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957001101 DNA-binding site [nucleotide binding]; DNA binding site 482957001102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957001103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957001104 homodimer interface [polypeptide binding]; other site 482957001105 catalytic residue [active] 482957001106 transcriptional activator TtdR; Provisional; Region: PRK09801 482957001107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001108 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 482957001109 putative effector binding pocket; other site 482957001110 putative dimerization interface [polypeptide binding]; other site 482957001111 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 482957001112 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 482957001113 substrate binding site [chemical binding]; other site 482957001114 ligand binding site [chemical binding]; other site 482957001115 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 482957001116 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 482957001117 substrate binding site [chemical binding]; other site 482957001118 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 482957001119 benzoate transport; Region: 2A0115; TIGR00895 482957001120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001122 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957001123 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957001124 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 482957001125 active site 482957001126 catalytic residues [active] 482957001127 metal binding site [ion binding]; metal-binding site 482957001128 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957001129 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001130 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 482957001131 putative dimerization interface [polypeptide binding]; other site 482957001132 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 482957001133 MoaE interaction surface [polypeptide binding]; other site 482957001134 MoeB interaction surface [polypeptide binding]; other site 482957001135 thiocarboxylated glycine; other site 482957001136 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 482957001137 MoaE homodimer interface [polypeptide binding]; other site 482957001138 MoaD interaction [polypeptide binding]; other site 482957001139 active site residues [active] 482957001140 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 482957001141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957001142 FeS/SAM binding site; other site 482957001143 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 482957001144 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 482957001145 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 482957001146 dimer interface [polypeptide binding]; other site 482957001147 putative functional site; other site 482957001148 putative MPT binding site; other site 482957001149 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 482957001150 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 482957001151 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 482957001152 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 482957001153 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 482957001154 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 482957001155 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 482957001156 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957001157 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 482957001158 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 482957001159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957001160 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 482957001161 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 482957001162 active site 482957001163 HIGH motif; other site 482957001164 dimer interface [polypeptide binding]; other site 482957001165 KMSKS motif; other site 482957001166 Killing trait; Region: RebB; pfam11747 482957001167 Killing trait; Region: RebB; pfam11747 482957001168 Killing trait; Region: RebB; pfam11747 482957001169 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 482957001170 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957001171 ligand binding site [chemical binding]; other site 482957001172 flexible hinge region; other site 482957001173 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 482957001174 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 482957001175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 482957001176 Killing trait; Region: RebB; pfam11747 482957001177 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 482957001178 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 482957001179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 482957001180 Probable transposase; Region: OrfB_IS605; pfam01385 482957001181 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 482957001182 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 482957001183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957001184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957001185 homotrimer interaction site [polypeptide binding]; other site 482957001186 putative active site [active] 482957001187 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 482957001188 acetylornithine deacetylase; Provisional; Region: PRK07522 482957001189 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 482957001190 metal binding site [ion binding]; metal-binding site 482957001191 putative dimer interface [polypeptide binding]; other site 482957001192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957001193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001194 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 482957001195 putative substrate binding pocket [chemical binding]; other site 482957001196 dimerization interface [polypeptide binding]; other site 482957001197 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 482957001198 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957001199 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 482957001200 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 482957001201 putative molybdopterin cofactor binding site [chemical binding]; other site 482957001202 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 482957001203 putative molybdopterin cofactor binding site; other site 482957001204 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 482957001205 Clp amino terminal domain; Region: Clp_N; pfam02861 482957001206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957001207 Walker A motif; other site 482957001208 ATP binding site [chemical binding]; other site 482957001209 Walker B motif; other site 482957001210 arginine finger; other site 482957001211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957001212 Walker A motif; other site 482957001213 ATP binding site [chemical binding]; other site 482957001214 Walker B motif; other site 482957001215 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 482957001216 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957001217 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 482957001218 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 482957001219 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957001220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001221 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 482957001222 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 482957001223 Protein of unknown function, DUF608; Region: DUF608; pfam04685 482957001224 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957001225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957001226 DNA-binding site [nucleotide binding]; DNA binding site 482957001227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957001228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957001229 homodimer interface [polypeptide binding]; other site 482957001230 catalytic residue [active] 482957001231 formate dehydrogenase; Provisional; Region: PRK07574 482957001232 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 482957001233 dimerization interface [polypeptide binding]; other site 482957001234 ligand binding site [chemical binding]; other site 482957001235 NAD binding site [chemical binding]; other site 482957001236 catalytic site [active] 482957001237 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 482957001238 [2Fe-2S] cluster binding site [ion binding]; other site 482957001239 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 482957001240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957001241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957001242 MarC family integral membrane protein; Region: MarC; cl00919 482957001243 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 482957001244 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957001245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957001246 active site 482957001247 phosphorylation site [posttranslational modification] 482957001248 intermolecular recognition site; other site 482957001249 dimerization interface [polypeptide binding]; other site 482957001250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957001251 Walker A motif; other site 482957001252 ATP binding site [chemical binding]; other site 482957001253 Walker B motif; other site 482957001254 arginine finger; other site 482957001255 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957001256 PAS domain; Region: PAS; smart00091 482957001257 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 482957001258 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957001259 putative active site [active] 482957001260 heme pocket [chemical binding]; other site 482957001261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957001262 dimer interface [polypeptide binding]; other site 482957001263 phosphorylation site [posttranslational modification] 482957001264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957001265 ATP binding site [chemical binding]; other site 482957001266 Mg2+ binding site [ion binding]; other site 482957001267 G-X-G motif; other site 482957001268 Response regulator receiver domain; Region: Response_reg; pfam00072 482957001269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957001270 active site 482957001271 phosphorylation site [posttranslational modification] 482957001272 intermolecular recognition site; other site 482957001273 dimerization interface [polypeptide binding]; other site 482957001274 FOG: CBS domain [General function prediction only]; Region: COG0517 482957001275 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 482957001276 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 482957001277 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 482957001278 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 482957001279 Protein of unknwon function (DUF3008); Region: DUF3008; pfam11450 482957001280 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 482957001281 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 482957001282 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 482957001283 Fic/DOC family; Region: Fic; pfam02661 482957001284 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 482957001285 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 482957001286 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 482957001287 active site 482957001288 catalytic site [active] 482957001289 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 482957001290 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 482957001291 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 482957001292 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 482957001293 active site 482957001294 catalytic site [active] 482957001295 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 482957001296 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 482957001297 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 482957001298 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 482957001299 active site 482957001300 catalytic site [active] 482957001301 glycogen branching enzyme; Provisional; Region: PRK05402 482957001302 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 482957001303 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 482957001304 active site 482957001305 catalytic site [active] 482957001306 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 482957001307 trehalose synthase; Region: treS_nterm; TIGR02456 482957001308 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 482957001309 active site 482957001310 catalytic site [active] 482957001311 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 482957001312 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 482957001313 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 482957001314 active site 482957001315 catalytic site [active] 482957001316 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 482957001317 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 482957001318 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 482957001319 active site 482957001320 homodimer interface [polypeptide binding]; other site 482957001321 catalytic site [active] 482957001322 acceptor binding site [chemical binding]; other site 482957001323 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 482957001324 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 482957001325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957001326 motif II; other site 482957001327 putative arabinose transporter; Provisional; Region: PRK03545 482957001328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001329 putative substrate translocation pore; other site 482957001330 short chain dehydrogenase; Provisional; Region: PRK06172 482957001331 classical (c) SDRs; Region: SDR_c; cd05233 482957001332 NAD(P) binding site [chemical binding]; other site 482957001333 active site 482957001334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957001335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001336 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957001337 putative effector binding pocket; other site 482957001338 dimerization interface [polypeptide binding]; other site 482957001339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957001340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957001341 DNA binding residues [nucleotide binding] 482957001342 indole acetimide hydrolase; Validated; Region: PRK07488 482957001343 Amidase; Region: Amidase; cl11426 482957001344 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 482957001345 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 482957001346 octamer interface [polypeptide binding]; other site 482957001347 active site 482957001348 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 482957001349 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 482957001350 dimer interface [polypeptide binding]; other site 482957001351 active site 482957001352 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 482957001353 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 482957001354 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 482957001355 putative alpha subunit interface [polypeptide binding]; other site 482957001356 putative active site [active] 482957001357 putative substrate binding site [chemical binding]; other site 482957001358 Fe binding site [ion binding]; other site 482957001359 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 482957001360 inter-subunit interface; other site 482957001361 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 482957001362 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957001363 catalytic loop [active] 482957001364 iron binding site [ion binding]; other site 482957001365 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 482957001366 FAD binding pocket [chemical binding]; other site 482957001367 FAD binding motif [chemical binding]; other site 482957001368 phosphate binding motif [ion binding]; other site 482957001369 beta-alpha-beta structure motif; other site 482957001370 NAD binding pocket [chemical binding]; other site 482957001371 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 482957001372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957001373 NAD(P) binding site [chemical binding]; other site 482957001374 active site 482957001375 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 482957001376 homotrimer interaction site [polypeptide binding]; other site 482957001377 putative active site [active] 482957001378 Creatinine amidohydrolase; Region: Creatininase; pfam02633 482957001379 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 482957001380 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 482957001381 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 482957001382 Uncharacterized conserved protein [Function unknown]; Region: COG2427 482957001383 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 482957001384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957001385 active site 482957001386 phosphorylation site [posttranslational modification] 482957001387 intermolecular recognition site; other site 482957001388 dimerization interface [polypeptide binding]; other site 482957001389 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957001390 DNA binding site [nucleotide binding] 482957001391 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957001392 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957001393 Cupin; Region: Cupin_6; pfam12852 482957001394 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957001395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001396 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 482957001397 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957001398 regulatory protein interface [polypeptide binding]; other site 482957001399 active site 482957001400 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 482957001401 regulatory phosphorylation site [posttranslational modification]; other site 482957001402 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 482957001403 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 482957001404 PhnA protein; Region: PhnA; pfam03831 482957001405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957001406 S-adenosylmethionine binding site [chemical binding]; other site 482957001407 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 482957001408 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 482957001409 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 482957001410 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 482957001411 short chain dehydrogenase; Provisional; Region: PRK08265 482957001412 classical (c) SDRs; Region: SDR_c; cd05233 482957001413 NAD(P) binding site [chemical binding]; other site 482957001414 active site 482957001415 Isochorismatase family; Region: Isochorismatase; pfam00857 482957001416 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 482957001417 catalytic triad [active] 482957001418 conserved cis-peptide bond; other site 482957001419 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 482957001420 inter-subunit interface; other site 482957001421 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 482957001422 Rieske non-heme iron oxygenase (RO) family, Anthranilate 1,2-dioxygenase (AntDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_AntDO; cd03538 482957001423 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 482957001424 putative alpha subunit interface [polypeptide binding]; other site 482957001425 putative active site [active] 482957001426 putative substrate binding site [chemical binding]; other site 482957001427 Fe binding site [ion binding]; other site 482957001428 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957001429 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 482957001430 FMN-binding pocket [chemical binding]; other site 482957001431 flavin binding motif; other site 482957001432 phosphate binding motif [ion binding]; other site 482957001433 beta-alpha-beta structure motif; other site 482957001434 NAD binding pocket [chemical binding]; other site 482957001435 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957001436 catalytic loop [active] 482957001437 iron binding site [ion binding]; other site 482957001438 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957001439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957001441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 482957001442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957001443 ATP binding site [chemical binding]; other site 482957001444 Mg2+ binding site [ion binding]; other site 482957001445 G-X-G motif; other site 482957001446 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 482957001447 active site 2 [active] 482957001448 active site 1 [active] 482957001449 Response regulator receiver domain; Region: Response_reg; pfam00072 482957001450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957001451 active site 482957001452 phosphorylation site [posttranslational modification] 482957001453 intermolecular recognition site; other site 482957001454 Cupin; Region: Cupin_6; pfam12852 482957001455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957001457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001458 oxidoreductase; Provisional; Region: PRK06196 482957001459 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 482957001460 putative NAD(P) binding site [chemical binding]; other site 482957001461 active site 482957001462 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 482957001463 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 482957001464 Flavin binding site [chemical binding]; other site 482957001465 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 482957001466 active site 482957001467 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 482957001468 dimer interface [polypeptide binding]; other site 482957001469 non-prolyl cis peptide bond; other site 482957001470 insertion regions; other site 482957001471 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957001472 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957001473 trimer interface [polypeptide binding]; other site 482957001474 eyelet of channel; other site 482957001475 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 482957001476 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957001477 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957001478 substrate binding pocket [chemical binding]; other site 482957001479 membrane-bound complex binding site; other site 482957001480 Glycosyl transferase family 41; Region: Glyco_transf_41; pfam13844 482957001481 Tetratricopeptide repeat; Region: TPR_16; pfam13432 482957001482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957001483 binding surface 482957001484 TPR motif; other site 482957001485 TPR repeat; Region: TPR_11; pfam13414 482957001486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 482957001487 TPR motif; other site 482957001488 binding surface 482957001489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957001490 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 482957001491 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 482957001492 NodB motif; other site 482957001493 putative active site [active] 482957001494 putative catalytic site [active] 482957001495 putative Zn binding site [ion binding]; other site 482957001496 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 482957001497 dimer interface [polypeptide binding]; other site 482957001498 catalytic triad [active] 482957001499 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 482957001500 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 482957001501 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 482957001502 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 482957001503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957001504 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 482957001505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957001506 DNA binding residues [nucleotide binding] 482957001507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001508 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957001509 putative substrate translocation pore; other site 482957001510 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 482957001511 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 482957001512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957001513 N-terminal plug; other site 482957001514 ligand-binding site [chemical binding]; other site 482957001515 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 482957001516 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 482957001517 Walker A/P-loop; other site 482957001518 ATP binding site [chemical binding]; other site 482957001519 Q-loop/lid; other site 482957001520 ABC transporter signature motif; other site 482957001521 Walker B; other site 482957001522 D-loop; other site 482957001523 H-loop/switch region; other site 482957001524 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 482957001525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 482957001526 ABC-ATPase subunit interface; other site 482957001527 dimer interface [polypeptide binding]; other site 482957001528 putative PBP binding regions; other site 482957001529 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 482957001530 intersubunit interface [polypeptide binding]; other site 482957001531 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957001532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957001533 active site 482957001534 phosphorylation site [posttranslational modification] 482957001535 intermolecular recognition site; other site 482957001536 dimerization interface [polypeptide binding]; other site 482957001537 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957001538 DNA binding site [nucleotide binding] 482957001539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957001540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957001541 dimerization interface [polypeptide binding]; other site 482957001542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957001543 ATP binding site [chemical binding]; other site 482957001544 Mg2+ binding site [ion binding]; other site 482957001545 G-X-G motif; other site 482957001546 Radical SAM superfamily; Region: Radical_SAM; pfam04055 482957001547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957001548 FeS/SAM binding site; other site 482957001549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957001550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957001551 metal binding site [ion binding]; metal-binding site 482957001552 active site 482957001553 I-site; other site 482957001554 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957001555 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 482957001556 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 482957001557 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957001558 metal binding site [ion binding]; metal-binding site 482957001559 active site 482957001560 I-site; other site 482957001561 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957001562 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957001563 classical (c) SDRs; Region: SDR_c; cd05233 482957001564 NAD(P) binding site [chemical binding]; other site 482957001565 active site 482957001566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957001567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957001568 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957001569 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 482957001570 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 482957001571 acyl-activating enzyme (AAE) consensus motif; other site 482957001572 acyl-activating enzyme (AAE) consensus motif; other site 482957001573 putative AMP binding site [chemical binding]; other site 482957001574 putative active site [active] 482957001575 putative CoA binding site [chemical binding]; other site 482957001576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957001577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957001578 NAD(P) binding site [chemical binding]; other site 482957001579 active site 482957001580 enoyl-CoA hydratase; Provisional; Region: PRK08252 482957001581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957001582 substrate binding site [chemical binding]; other site 482957001583 oxyanion hole (OAH) forming residues; other site 482957001584 trimer interface [polypeptide binding]; other site 482957001585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957001586 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957001587 NAD(P) binding site [chemical binding]; other site 482957001588 active site 482957001589 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 482957001590 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957001591 dimer interface [polypeptide binding]; other site 482957001592 active site 482957001593 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 482957001594 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 482957001595 active site 482957001596 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 482957001597 catalytic triad [active] 482957001598 dimer interface [polypeptide binding]; other site 482957001599 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957001600 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957001601 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 482957001602 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957001603 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 482957001604 acyl-activating enzyme (AAE) consensus motif; other site 482957001605 putative AMP binding site [chemical binding]; other site 482957001606 putative active site [active] 482957001607 putative CoA binding site [chemical binding]; other site 482957001608 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957001609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957001610 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957001611 classical (c) SDRs; Region: SDR_c; cd05233 482957001612 NAD(P) binding site [chemical binding]; other site 482957001613 active site 482957001614 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 482957001615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957001616 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 482957001617 acyl-activating enzyme (AAE) consensus motif; other site 482957001618 putative AMP binding site [chemical binding]; other site 482957001619 putative active site [active] 482957001620 putative CoA binding site [chemical binding]; other site 482957001621 Transposase, Mutator family; Region: Transposase_mut; pfam00872 482957001622 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957001623 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957001624 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957001625 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 482957001626 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957001627 active site 482957001628 enoyl-CoA hydratase; Provisional; Region: PRK09245 482957001629 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957001630 substrate binding site [chemical binding]; other site 482957001631 oxyanion hole (OAH) forming residues; other site 482957001632 trimer interface [polypeptide binding]; other site 482957001633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001634 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957001635 putative substrate translocation pore; other site 482957001636 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957001637 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957001638 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957001639 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 482957001640 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957001641 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 482957001642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957001643 NAD(P) binding site [chemical binding]; other site 482957001644 active site 482957001645 hypothetical protein; Provisional; Region: PRK07236 482957001646 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 482957001647 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957001648 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957001649 active site 482957001650 catalytic tetrad [active] 482957001651 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 482957001652 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957001653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001654 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 482957001655 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 482957001656 phosphate binding site [ion binding]; other site 482957001657 short chain dehydrogenase; Provisional; Region: PRK06125 482957001658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957001659 NAD(P) binding site [chemical binding]; other site 482957001660 active site 482957001661 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 482957001662 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957001663 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957001664 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957001665 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957001666 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957001667 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957001668 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 482957001669 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957001670 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957001671 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 482957001672 non-specific DNA interactions [nucleotide binding]; other site 482957001673 DNA binding site [nucleotide binding] 482957001674 sequence specific DNA binding site [nucleotide binding]; other site 482957001675 putative cAMP binding site [chemical binding]; other site 482957001676 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 482957001677 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957001678 active site 482957001679 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 482957001680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957001681 active site 482957001682 Nitronate monooxygenase; Region: NMO; pfam03060 482957001683 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957001684 FMN binding site [chemical binding]; other site 482957001685 substrate binding site [chemical binding]; other site 482957001686 putative catalytic residue [active] 482957001687 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 482957001688 SnoaL-like domain; Region: SnoaL_4; pfam13577 482957001689 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 482957001690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957001691 dimer interface [polypeptide binding]; other site 482957001692 active site 482957001693 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 482957001694 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 482957001695 putative active site [active] 482957001696 putative catalytic site [active] 482957001697 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 482957001698 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 482957001699 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 482957001700 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 482957001701 acyl-activating enzyme (AAE) consensus motif; other site 482957001702 putative AMP binding site [chemical binding]; other site 482957001703 putative active site [active] 482957001704 putative CoA binding site [chemical binding]; other site 482957001705 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957001706 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957001707 NAD(P) binding site [chemical binding]; other site 482957001708 catalytic residues [active] 482957001709 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957001710 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957001711 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957001712 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957001713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957001714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957001715 NAD(P) binding site [chemical binding]; other site 482957001716 active site 482957001717 benzoate transport; Region: 2A0115; TIGR00895 482957001718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001719 putative substrate translocation pore; other site 482957001720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957001722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001723 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 482957001724 putative dimerization interface [polypeptide binding]; other site 482957001725 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 482957001726 active site 2 [active] 482957001727 active site 1 [active] 482957001728 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 482957001729 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 482957001730 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 482957001731 active site 482957001732 Zn binding site [ion binding]; other site 482957001733 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 482957001734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957001735 putative substrate translocation pore; other site 482957001736 AAA domain; Region: AAA_17; pfam13207 482957001737 short chain dehydrogenase; Provisional; Region: PRK07478 482957001738 classical (c) SDRs; Region: SDR_c; cd05233 482957001739 NAD(P) binding site [chemical binding]; other site 482957001740 active site 482957001741 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957001742 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 482957001743 active site 482957001744 metal binding site [ion binding]; metal-binding site 482957001745 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 482957001746 trimer interface [polypeptide binding]; other site 482957001747 YadA-like C-terminal region; Region: YadA; pfam03895 482957001748 Response regulator receiver domain; Region: Response_reg; pfam00072 482957001749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957001750 active site 482957001751 phosphorylation site [posttranslational modification] 482957001752 intermolecular recognition site; other site 482957001753 dimerization interface [polypeptide binding]; other site 482957001754 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957001755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001756 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 482957001757 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957001758 N-terminal plug; other site 482957001759 ligand-binding site [chemical binding]; other site 482957001760 poly(beta-D-mannuronate) lyase; Provisional; Region: algL; PRK00325 482957001761 active site 482957001762 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957001763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001764 Dienelactone hydrolase family; Region: DLH; pfam01738 482957001765 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 482957001766 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957001767 short chain dehydrogenase; Provisional; Region: PRK08265 482957001768 classical (c) SDRs; Region: SDR_c; cd05233 482957001769 NAD(P) binding site [chemical binding]; other site 482957001770 active site 482957001771 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 482957001772 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 482957001773 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 482957001774 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957001775 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957001776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957001777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957001778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957001779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957001780 active site 482957001781 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 482957001782 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957001783 dimer interface [polypeptide binding]; other site 482957001784 active site 482957001785 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 482957001786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957001787 substrate binding site [chemical binding]; other site 482957001788 oxyanion hole (OAH) forming residues; other site 482957001789 trimer interface [polypeptide binding]; other site 482957001790 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957001791 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957001792 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957001793 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957001794 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 482957001795 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 482957001796 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 482957001797 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 482957001798 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 482957001799 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 482957001800 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 482957001801 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 482957001802 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 482957001803 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957001804 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 482957001805 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957001806 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 482957001807 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 482957001808 ATP binding site [chemical binding]; other site 482957001809 Walker A motif; other site 482957001810 hexamer interface [polypeptide binding]; other site 482957001811 Walker B motif; other site 482957001812 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 482957001813 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 482957001814 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 482957001815 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 482957001816 TadE-like protein; Region: TadE; pfam07811 482957001817 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 482957001818 TadE-like protein; Region: TadE; pfam07811 482957001819 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 482957001820 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 482957001821 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 482957001822 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 482957001823 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 482957001824 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 482957001825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957001826 Walker A motif; other site 482957001827 ATP binding site [chemical binding]; other site 482957001828 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 482957001829 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 482957001830 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 482957001831 Flp/Fap pilin component; Region: Flp_Fap; cl01585 482957001832 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 482957001833 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 482957001834 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 482957001835 Ligand binding site; other site 482957001836 Putative Catalytic site; other site 482957001837 DXD motif; other site 482957001838 Predicted membrane protein [Function unknown]; Region: COG2246 482957001839 GtrA-like protein; Region: GtrA; pfam04138 482957001840 Inclusion body protein; Region: PixA; pfam12306 482957001841 Inclusion body protein; Region: PixA; pfam12306 482957001842 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 482957001843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957001844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001845 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957001846 dimerization interface [polypeptide binding]; other site 482957001847 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232 482957001848 putative active site [active] 482957001849 Zn binding site [ion binding]; other site 482957001850 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 482957001851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957001852 Coenzyme A binding pocket [chemical binding]; other site 482957001853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957001854 Walker A motif; other site 482957001855 ATP binding site [chemical binding]; other site 482957001856 Walker B motif; other site 482957001857 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 482957001858 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 482957001859 metal ion-dependent adhesion site (MIDAS); other site 482957001860 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 482957001861 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 482957001862 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 482957001863 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 482957001864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 482957001865 dimer interface [polypeptide binding]; other site 482957001866 phosphorylation site [posttranslational modification] 482957001867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957001868 ATP binding site [chemical binding]; other site 482957001869 Mg2+ binding site [ion binding]; other site 482957001870 G-X-G motif; other site 482957001871 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 482957001872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957001873 active site 482957001874 phosphorylation site [posttranslational modification] 482957001875 intermolecular recognition site; other site 482957001876 dimerization interface [polypeptide binding]; other site 482957001877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 482957001878 Zn2+ binding site [ion binding]; other site 482957001879 Mg2+ binding site [ion binding]; other site 482957001880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957001881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957001882 Coenzyme A binding pocket [chemical binding]; other site 482957001883 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 482957001884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957001885 Walker A/P-loop; other site 482957001886 ATP binding site [chemical binding]; other site 482957001887 Q-loop/lid; other site 482957001888 ABC transporter signature motif; other site 482957001889 Walker B; other site 482957001890 D-loop; other site 482957001891 H-loop/switch region; other site 482957001892 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 482957001893 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 482957001894 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 482957001895 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 482957001896 ligand binding site [chemical binding]; other site 482957001897 homodimer interface [polypeptide binding]; other site 482957001898 NAD(P) binding site [chemical binding]; other site 482957001899 trimer interface B [polypeptide binding]; other site 482957001900 trimer interface A [polypeptide binding]; other site 482957001901 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 482957001902 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957001903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 482957001904 Coenzyme A binding pocket [chemical binding]; other site 482957001905 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 482957001906 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957001907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957001908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957001909 dimerization interface [polypeptide binding]; other site 482957001910 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 482957001911 short chain dehydrogenase; Provisional; Region: PRK06500 482957001912 classical (c) SDRs; Region: SDR_c; cd05233 482957001913 NAD(P) binding site [chemical binding]; other site 482957001914 active site 482957001915 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 482957001916 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 482957001917 conserved cys residue [active] 482957001918 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 482957001919 SnoaL-like domain; Region: SnoaL_3; pfam13474 482957001920 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957001921 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957001922 conserved cys residue [active] 482957001923 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 482957001925 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 482957001926 Cupin; Region: Cupin_6; pfam12852 482957001927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957001929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957001930 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957001931 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957001932 trimer interface [polypeptide binding]; other site 482957001933 eyelet of channel; other site 482957001934 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 482957001935 active site turn [active] 482957001936 phosphorylation site [posttranslational modification] 482957001937 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 482957001938 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 482957001939 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 482957001940 putative active site [active] 482957001941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957001942 DNA-binding site [nucleotide binding]; DNA binding site 482957001943 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 482957001944 UTRA domain; Region: UTRA; pfam07702 482957001945 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 482957001946 catalytic residues [active] 482957001947 dimer interface [polypeptide binding]; other site 482957001948 EthD domain; Region: EthD; cl17553 482957001949 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 482957001950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957001951 Coenzyme A binding pocket [chemical binding]; other site 482957001952 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 482957001953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957001954 DNA-binding site [nucleotide binding]; DNA binding site 482957001955 FCD domain; Region: FCD; pfam07729 482957001956 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 482957001957 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 482957001958 RNase II stability modulator; Provisional; Region: PRK10060 482957001959 PBP superfamily domain; Region: PBP_like_2; cl17296 482957001960 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 482957001961 Putative amidotransferase; Region: DUF4066; pfam13278 482957001962 conserved cys residue [active] 482957001963 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 482957001964 active site 482957001965 dimer interface [polypeptide binding]; other site 482957001966 motif 1; other site 482957001967 motif 2; other site 482957001968 motif 3; other site 482957001969 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 482957001970 anticodon binding site; other site 482957001971 N-formylglutamate amidohydrolase; Region: FGase; cl01522 482957001972 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 482957001973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957001974 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957001975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957001976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957001977 Coenzyme A binding pocket [chemical binding]; other site 482957001978 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 482957001979 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 482957001980 ATP binding site [chemical binding]; other site 482957001981 Mg++ binding site [ion binding]; other site 482957001982 motif III; other site 482957001983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957001984 nucleotide binding region [chemical binding]; other site 482957001985 ATP-binding site [chemical binding]; other site 482957001986 Helix-Turn-Helix DNA binding domain of the Cfa transcription regulator; Region: HTH_Cfa; cd04789 482957001987 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 482957001988 DNA binding residues [nucleotide binding] 482957001989 putative dimer interface [polypeptide binding]; other site 482957001990 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 482957001991 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957001992 S-adenosylmethionine binding site [chemical binding]; other site 482957001993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 482957001994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957001995 Coenzyme A binding pocket [chemical binding]; other site 482957001996 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 482957001997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957001998 substrate binding pocket [chemical binding]; other site 482957001999 membrane-bound complex binding site; other site 482957002000 hinge residues; other site 482957002001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002003 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 482957002004 putative effector binding pocket; other site 482957002005 putative dimerization interface [polypeptide binding]; other site 482957002006 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957002007 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 482957002008 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 482957002009 NADH(P)-binding; Region: NAD_binding_10; pfam13460 482957002010 putative NAD(P) binding site [chemical binding]; other site 482957002011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957002014 dimerization interface [polypeptide binding]; other site 482957002015 benzoate transport; Region: 2A0115; TIGR00895 482957002016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002017 putative substrate translocation pore; other site 482957002018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002019 putative substrate translocation pore; other site 482957002020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002022 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 482957002023 putative dimerization interface [polypeptide binding]; other site 482957002024 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002025 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002026 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 482957002027 classical (c) SDRs; Region: SDR_c; cd05233 482957002028 NAD(P) binding site [chemical binding]; other site 482957002029 active site 482957002030 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 482957002031 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 482957002032 putative NAD(P) binding site [chemical binding]; other site 482957002033 catalytic Zn binding site [ion binding]; other site 482957002034 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 482957002035 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957002036 NAD binding site [chemical binding]; other site 482957002037 catalytic residues [active] 482957002038 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 482957002039 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 482957002040 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 482957002041 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 482957002042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957002043 substrate binding site [chemical binding]; other site 482957002044 oxyanion hole (OAH) forming residues; other site 482957002045 trimer interface [polypeptide binding]; other site 482957002046 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957002047 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957002048 trimer interface [polypeptide binding]; other site 482957002049 eyelet of channel; other site 482957002050 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 482957002051 active site clefts [active] 482957002052 zinc binding site [ion binding]; other site 482957002053 dimer interface [polypeptide binding]; other site 482957002054 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 482957002055 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 482957002056 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957002057 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 482957002058 putative active site [active] 482957002059 putative FMN binding site [chemical binding]; other site 482957002060 putative substrate binding site [chemical binding]; other site 482957002061 putative catalytic residue [active] 482957002062 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 482957002063 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 482957002064 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 482957002065 putative active site [active] 482957002066 putative catalytic site [active] 482957002067 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957002068 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002069 active site 482957002070 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002071 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002072 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002073 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002074 WGR domain; Region: WGR; cl01581 482957002075 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 482957002076 putative FMN binding site [chemical binding]; other site 482957002077 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 482957002078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957002079 acyl-activating enzyme (AAE) consensus motif; other site 482957002080 AMP binding site [chemical binding]; other site 482957002081 active site 482957002082 CoA binding site [chemical binding]; other site 482957002083 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957002084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957002085 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 482957002086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002088 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 482957002089 putative dimerization interface [polypeptide binding]; other site 482957002090 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957002091 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002092 active site 482957002093 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 482957002094 Ligand binding site [chemical binding]; other site 482957002095 Electron transfer flavoprotein domain; Region: ETF; pfam01012 482957002096 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 482957002097 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 482957002098 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 482957002099 Uncharacterized conserved protein [Function unknown]; Region: COG3777 482957002100 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 482957002101 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 482957002102 active site 2 [active] 482957002103 active site 1 [active] 482957002104 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002105 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002106 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 482957002107 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 482957002108 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 482957002109 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 482957002110 putative NAD(P) binding site [chemical binding]; other site 482957002111 catalytic Zn binding site [ion binding]; other site 482957002112 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957002113 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957002114 NAD(P) binding site [chemical binding]; other site 482957002115 catalytic residues [active] 482957002116 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957002117 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957002118 NAD(P) binding site [chemical binding]; other site 482957002119 catalytic residues [active] 482957002120 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 482957002121 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 482957002122 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957002123 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957002124 trimer interface [polypeptide binding]; other site 482957002125 eyelet of channel; other site 482957002126 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957002127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957002128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957002129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957002130 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957002131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957002132 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 482957002133 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957002134 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957002135 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957002136 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957002137 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 482957002138 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957002139 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 482957002140 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 482957002141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957002143 putative substrate translocation pore; other site 482957002144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002145 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 482957002146 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 482957002147 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957002148 N-terminal plug; other site 482957002149 ligand-binding site [chemical binding]; other site 482957002150 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957002151 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957002152 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957002153 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957002154 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 482957002155 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 482957002156 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 482957002157 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 482957002158 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 482957002159 pyruvate carboxylase; Reviewed; Region: PRK12999 482957002160 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 482957002161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 482957002162 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 482957002163 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 482957002164 active site 482957002165 catalytic residues [active] 482957002166 metal binding site [ion binding]; metal-binding site 482957002167 homodimer binding site [polypeptide binding]; other site 482957002168 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 482957002169 carboxyltransferase (CT) interaction site; other site 482957002170 biotinylation site [posttranslational modification]; other site 482957002171 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957002172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002173 active site 482957002174 enoyl-CoA hydratase; Region: PLN02864 482957002175 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 482957002176 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 482957002177 dimer interaction site [polypeptide binding]; other site 482957002178 substrate-binding tunnel; other site 482957002179 active site 482957002180 catalytic site [active] 482957002181 substrate binding site [chemical binding]; other site 482957002182 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957002183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957002184 NAD(P) binding site [chemical binding]; other site 482957002185 active site 482957002186 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 482957002187 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957002188 dimer interface [polypeptide binding]; other site 482957002189 active site 482957002190 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 482957002191 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 482957002192 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 482957002193 acyl-activating enzyme (AAE) consensus motif; other site 482957002194 putative AMP binding site [chemical binding]; other site 482957002195 putative active site [active] 482957002196 putative CoA binding site [chemical binding]; other site 482957002197 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002198 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002199 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 482957002200 conserved cys residue [active] 482957002201 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957002202 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957002203 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 482957002204 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957002205 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957002206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957002207 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 482957002208 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957002209 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 482957002210 N-terminal domain interface [polypeptide binding]; other site 482957002211 dimer interface [polypeptide binding]; other site 482957002212 substrate binding pocket (H-site) [chemical binding]; other site 482957002213 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 482957002214 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 482957002215 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002217 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 482957002218 putative effector binding pocket; other site 482957002219 putative dimerization interface [polypeptide binding]; other site 482957002220 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 482957002221 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957002222 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957002223 NAD(P) binding site [chemical binding]; other site 482957002224 catalytic residues [active] 482957002225 choline dehydrogenase; Validated; Region: PRK02106 482957002226 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957002227 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957002228 Cytochrome c; Region: Cytochrom_C; pfam00034 482957002229 Cytochrome c; Region: Cytochrom_C; pfam00034 482957002230 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 482957002231 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957002232 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 482957002233 Domain of unknown function (DUF336); Region: DUF336; pfam03928 482957002234 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 482957002235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002236 D-galactonate transporter; Region: 2A0114; TIGR00893 482957002237 putative substrate translocation pore; other site 482957002238 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 482957002239 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 482957002240 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 482957002241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957002242 Walker A/P-loop; other site 482957002243 ATP binding site [chemical binding]; other site 482957002244 Q-loop/lid; other site 482957002245 ABC transporter signature motif; other site 482957002246 Walker B; other site 482957002247 D-loop; other site 482957002248 H-loop/switch region; other site 482957002249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957002250 Walker A/P-loop; other site 482957002251 ATP binding site [chemical binding]; other site 482957002252 Q-loop/lid; other site 482957002253 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 482957002254 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 482957002255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957002256 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957002257 catalytic site [active] 482957002258 GYD domain; Region: GYD; pfam08734 482957002259 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 482957002260 High potential iron-sulfur protein; Region: HIPIP; pfam01355 482957002261 Predicted small integral membrane protein [Function unknown]; Region: COG5605 482957002262 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 482957002263 Subunit I/III interface [polypeptide binding]; other site 482957002264 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 482957002265 Subunit I/III interface [polypeptide binding]; other site 482957002266 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 482957002267 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 482957002268 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 482957002269 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 482957002270 Cytochrome c; Region: Cytochrom_C; cl11414 482957002271 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 482957002272 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 482957002273 methionine synthase; Provisional; Region: PRK01207 482957002274 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 482957002275 substrate binding site [chemical binding]; other site 482957002276 THF binding site; other site 482957002277 zinc-binding site [ion binding]; other site 482957002278 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 482957002279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 482957002280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002282 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 482957002283 putative dimerization interface [polypeptide binding]; other site 482957002284 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957002285 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 482957002286 ligand binding site [chemical binding]; other site 482957002287 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 482957002288 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 482957002289 trimer interface [polypeptide binding]; other site 482957002290 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 482957002291 trimer interface [polypeptide binding]; other site 482957002292 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 482957002293 trimer interface [polypeptide binding]; other site 482957002294 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 482957002295 YadA-like C-terminal region; Region: YadA; pfam03895 482957002296 Response regulator receiver domain; Region: Response_reg; pfam00072 482957002297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957002298 active site 482957002299 phosphorylation site [posttranslational modification] 482957002300 intermolecular recognition site; other site 482957002301 dimerization interface [polypeptide binding]; other site 482957002302 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957002303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957002304 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 482957002305 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 482957002306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957002307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957002308 dimer interface [polypeptide binding]; other site 482957002309 phosphorylation site [posttranslational modification] 482957002310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957002311 ATP binding site [chemical binding]; other site 482957002312 Mg2+ binding site [ion binding]; other site 482957002313 G-X-G motif; other site 482957002314 Pirin-related protein [General function prediction only]; Region: COG1741 482957002315 Pirin; Region: Pirin; pfam02678 482957002316 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 482957002317 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957002318 Uncharacterized conserved protein [Function unknown]; Region: COG2353 482957002319 LysR family transcriptional regulator; Provisional; Region: PRK14997 482957002320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002321 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957002322 putative effector binding pocket; other site 482957002323 dimerization interface [polypeptide binding]; other site 482957002324 H-NS histone family; Region: Histone_HNS; pfam00816 482957002325 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957002326 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 482957002327 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 482957002328 active site 482957002329 tetramer interface; other site 482957002330 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 482957002331 BNR repeat-like domain; Region: BNR_2; pfam13088 482957002332 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 482957002333 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 482957002334 putative active site [active] 482957002335 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 482957002336 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 482957002337 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 482957002338 Ligand binding site; other site 482957002339 oligomer interface; other site 482957002340 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 482957002341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957002342 active site 482957002343 motif I; other site 482957002344 motif II; other site 482957002345 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 482957002346 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 482957002347 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957002348 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957002349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957002350 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 482957002351 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957002352 putative acyl transferase; Provisional; Region: PRK10191 482957002353 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 482957002354 trimer interface [polypeptide binding]; other site 482957002355 active site 482957002356 substrate binding site [chemical binding]; other site 482957002357 CoA binding site [chemical binding]; other site 482957002358 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 482957002359 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 482957002360 tyrosine kinase; Provisional; Region: PRK11519 482957002361 Chain length determinant protein; Region: Wzz; pfam02706 482957002362 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 482957002363 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 482957002364 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 482957002365 Low molecular weight phosphatase family; Region: LMWPc; cd00115 482957002366 active site 482957002367 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 482957002368 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 482957002369 SLBB domain; Region: SLBB; pfam10531 482957002370 Bacterial sugar transferase; Region: Bac_transf; pfam02397 482957002371 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 482957002372 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957002373 proline/glycine betaine transporter; Provisional; Region: PRK10642 482957002374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002375 putative substrate translocation pore; other site 482957002376 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 482957002377 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957002378 catalytic site [active] 482957002379 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957002380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002381 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957002382 dimerization interface [polypeptide binding]; other site 482957002383 substrate binding pocket [chemical binding]; other site 482957002384 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 482957002385 dinuclear metal binding motif [ion binding]; other site 482957002386 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 482957002387 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957002388 putative di-iron ligands [ion binding]; other site 482957002389 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 482957002390 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 482957002391 acyl-activating enzyme (AAE) consensus motif; other site 482957002392 active site 482957002393 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 482957002394 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 482957002395 Walker A/P-loop; other site 482957002396 ATP binding site [chemical binding]; other site 482957002397 Q-loop/lid; other site 482957002398 ABC transporter signature motif; other site 482957002399 Walker B; other site 482957002400 D-loop; other site 482957002401 H-loop/switch region; other site 482957002402 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 482957002403 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 482957002404 FtsX-like permease family; Region: FtsX; pfam02687 482957002405 Phosphopantetheine attachment site; Region: PP-binding; cl09936 482957002406 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 482957002407 dinuclear metal binding motif [ion binding]; other site 482957002408 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 482957002409 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 482957002410 dimer interface [polypeptide binding]; other site 482957002411 active site 482957002412 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 482957002413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 482957002414 dimer interface [polypeptide binding]; other site 482957002415 active site 482957002416 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957002417 catalytic residues [active] 482957002418 substrate binding site [chemical binding]; other site 482957002419 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 482957002420 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957002421 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957002422 acyl-activating enzyme (AAE) consensus motif; other site 482957002423 acyl-activating enzyme (AAE) consensus motif; other site 482957002424 AMP binding site [chemical binding]; other site 482957002425 active site 482957002426 CoA binding site [chemical binding]; other site 482957002427 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957002428 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002429 active site 482957002430 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 482957002431 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 482957002432 citrylCoA binding site [chemical binding]; other site 482957002433 oxalacetate binding site [chemical binding]; other site 482957002434 coenzyme A binding site [chemical binding]; other site 482957002435 catalytic triad [active] 482957002436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957002437 S-adenosylmethionine binding site [chemical binding]; other site 482957002438 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 482957002439 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 482957002440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957002441 Walker A/P-loop; other site 482957002442 ATP binding site [chemical binding]; other site 482957002443 Q-loop/lid; other site 482957002444 ABC transporter signature motif; other site 482957002445 Walker B; other site 482957002446 D-loop; other site 482957002447 H-loop/switch region; other site 482957002448 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 482957002449 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 482957002450 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957002451 FAD binding domain; Region: FAD_binding_4; pfam01565 482957002452 DctM-like transporters; Region: DctM; pfam06808 482957002453 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 482957002454 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 482957002455 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 482957002456 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 482957002457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 482957002458 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 482957002459 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 482957002460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002462 LysR substrate binding domain; Region: LysR_substrate; pfam03466 482957002463 dimerization interface [polypeptide binding]; other site 482957002464 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957002465 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957002466 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957002467 dimerization interface [polypeptide binding]; other site 482957002468 DNA binding residues [nucleotide binding] 482957002469 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 482957002470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957002471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957002472 homodimer interface [polypeptide binding]; other site 482957002473 catalytic residue [active] 482957002474 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 482957002475 homotrimer interaction site [polypeptide binding]; other site 482957002476 putative active site [active] 482957002477 H-NS histone family; Region: Histone_HNS; pfam00816 482957002478 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957002479 Cupin domain; Region: Cupin_2; pfam07883 482957002480 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002481 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002482 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957002483 dimerization interface [polypeptide binding]; other site 482957002484 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957002485 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957002486 metal binding site [ion binding]; metal-binding site 482957002487 putative dimer interface [polypeptide binding]; other site 482957002488 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957002489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957002490 substrate binding pocket [chemical binding]; other site 482957002491 membrane-bound complex binding site; other site 482957002492 hinge residues; other site 482957002493 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957002494 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957002495 trimer interface [polypeptide binding]; other site 482957002496 eyelet of channel; other site 482957002497 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957002498 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957002499 trimer interface [polypeptide binding]; other site 482957002500 eyelet of channel; other site 482957002501 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 482957002502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957002503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957002504 Putative cyclase; Region: Cyclase; pfam04199 482957002505 fumarylacetoacetase; Region: PLN02856 482957002506 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 482957002507 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957002508 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957002509 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957002510 trimer interface [polypeptide binding]; other site 482957002511 eyelet of channel; other site 482957002512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002513 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957002514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957002517 dimerization interface [polypeptide binding]; other site 482957002518 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957002519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957002521 dimerization interface [polypeptide binding]; other site 482957002522 LysE type translocator; Region: LysE; cl00565 482957002523 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957002524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957002526 dimerization interface [polypeptide binding]; other site 482957002527 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 482957002528 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 482957002529 NAD(P) binding site [chemical binding]; other site 482957002530 catalytic residues [active] 482957002531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957002532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957002533 WHG domain; Region: WHG; pfam13305 482957002534 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 482957002535 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 482957002536 potential catalytic triad [active] 482957002537 conserved cys residue [active] 482957002538 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 482957002539 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 482957002540 DNA binding residues [nucleotide binding] 482957002541 Uncharacterized conserved protein [Function unknown]; Region: COG3268 482957002542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957002543 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 482957002544 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 482957002545 DNA binding residues [nucleotide binding] 482957002546 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957002547 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957002548 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957002549 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 482957002550 C-terminal domain interface [polypeptide binding]; other site 482957002551 GSH binding site (G-site) [chemical binding]; other site 482957002552 dimer interface [polypeptide binding]; other site 482957002553 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 482957002554 N-terminal domain interface [polypeptide binding]; other site 482957002555 Predicted transcriptional regulator [Transcription]; Region: COG2378 482957002556 HTH domain; Region: HTH_11; pfam08279 482957002557 WYL domain; Region: WYL; pfam13280 482957002558 benzoate transport; Region: 2A0115; TIGR00895 482957002559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002560 putative substrate translocation pore; other site 482957002561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002562 choline dehydrogenase; Validated; Region: PRK02106 482957002563 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957002564 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 482957002565 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957002566 NAD binding site [chemical binding]; other site 482957002567 catalytic residues [active] 482957002568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957002571 dimerization interface [polypeptide binding]; other site 482957002572 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002573 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002574 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002575 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002576 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 482957002577 DUF35 OB-fold domain; Region: DUF35; pfam01796 482957002578 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 482957002579 active site 482957002580 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 482957002581 homodimer interaction site [polypeptide binding]; other site 482957002582 putative active site [active] 482957002583 putative catalytic site [active] 482957002584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957002585 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002586 active site 482957002587 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957002588 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957002589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002590 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957002591 putative substrate translocation pore; other site 482957002592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 482957002593 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 482957002594 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 482957002595 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 482957002596 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002597 active site 482957002598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002599 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 482957002600 active site 482957002601 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 482957002602 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 482957002603 active site 482957002604 non-prolyl cis peptide bond; other site 482957002605 benzoate transport; Region: 2A0115; TIGR00895 482957002606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002607 putative substrate translocation pore; other site 482957002608 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957002609 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957002610 substrate binding pocket [chemical binding]; other site 482957002611 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 482957002612 membrane-bound complex binding site; other site 482957002613 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957002614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957002615 dimer interface [polypeptide binding]; other site 482957002616 conserved gate region; other site 482957002617 putative PBP binding loops; other site 482957002618 ABC-ATPase subunit interface; other site 482957002619 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 482957002620 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957002621 Walker A/P-loop; other site 482957002622 ATP binding site [chemical binding]; other site 482957002623 Q-loop/lid; other site 482957002624 ABC transporter signature motif; other site 482957002625 Walker B; other site 482957002626 D-loop; other site 482957002627 H-loop/switch region; other site 482957002628 OsmC-like protein; Region: OsmC; pfam02566 482957002629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 482957002630 dimerization interface [polypeptide binding]; other site 482957002631 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957002632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957002633 dimer interface [polypeptide binding]; other site 482957002634 putative CheW interface [polypeptide binding]; other site 482957002635 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957002636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002637 putative substrate translocation pore; other site 482957002638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002639 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 482957002640 putative dimer interface [polypeptide binding]; other site 482957002641 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957002642 Cupin domain; Region: Cupin_2; pfam07883 482957002643 Predicted transcriptional regulator [Transcription]; Region: COG2345 482957002644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957002645 putative DNA binding site [nucleotide binding]; other site 482957002646 putative Zn2+ binding site [ion binding]; other site 482957002647 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 482957002648 putative heme binding pocket [chemical binding]; other site 482957002649 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 482957002650 Uncharacterized conserved protein [Function unknown]; Region: COG1262 482957002651 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 482957002652 AAA domain; Region: AAA_33; pfam13671 482957002653 AAA domain; Region: AAA_17; pfam13207 482957002654 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 482957002655 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957002656 protein binding site [polypeptide binding]; other site 482957002657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957002658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957002659 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 482957002660 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 482957002661 Active site cavity [active] 482957002662 catalytic acid [active] 482957002663 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 482957002664 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 482957002665 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 482957002666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957002667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957002668 DNA binding residues [nucleotide binding] 482957002669 dimerization interface [polypeptide binding]; other site 482957002670 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 482957002671 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957002672 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 482957002673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002674 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 482957002675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957002676 dimerization interface [polypeptide binding]; other site 482957002677 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 482957002678 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 482957002679 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957002680 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957002681 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957002682 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957002683 Sulfatase; Region: Sulfatase; cl17466 482957002684 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 482957002685 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 482957002686 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957002687 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 482957002688 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 482957002689 Sel1-like repeats; Region: SEL1; smart00671 482957002690 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957002691 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 482957002692 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957002693 Methyltransferase domain; Region: Methyltransf_11; pfam08241 482957002694 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 482957002695 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 482957002696 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 482957002697 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 482957002698 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 482957002699 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 482957002700 Integrase core domain; Region: rve_3; cl15866 482957002701 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 482957002702 Uncharacterized conserved protein [Function unknown]; Region: COG5476 482957002703 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 482957002704 MlrC C-terminus; Region: MlrC_C; pfam07171 482957002705 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 482957002706 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957002707 NAD binding site [chemical binding]; other site 482957002708 catalytic residues [active] 482957002709 hypothetical protein; Provisional; Region: PRK06541 482957002710 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957002711 inhibitor-cofactor binding pocket; inhibition site 482957002712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957002713 catalytic residue [active] 482957002714 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 482957002715 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957002716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957002717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957002718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957002719 dimer interface [polypeptide binding]; other site 482957002720 conserved gate region; other site 482957002721 putative PBP binding loops; other site 482957002722 ABC-ATPase subunit interface; other site 482957002723 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 482957002724 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 482957002725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957002726 dimer interface [polypeptide binding]; other site 482957002727 conserved gate region; other site 482957002728 ABC-ATPase subunit interface; other site 482957002729 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 482957002730 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 482957002731 Walker A/P-loop; other site 482957002732 ATP binding site [chemical binding]; other site 482957002733 Q-loop/lid; other site 482957002734 ABC transporter signature motif; other site 482957002735 Walker B; other site 482957002736 D-loop; other site 482957002737 H-loop/switch region; other site 482957002738 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582 482957002739 FOG: CBS domain [General function prediction only]; Region: COG0517 482957002740 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 482957002741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957002742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 482957002743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957002744 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957002745 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 482957002746 NAD binding site [chemical binding]; other site 482957002747 homodimer interface [polypeptide binding]; other site 482957002748 active site 482957002749 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 482957002750 putative active site [active] 482957002751 putative catalytic site [active] 482957002752 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 482957002753 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957002754 active site 482957002755 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 482957002756 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 482957002757 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957002758 dimer interface [polypeptide binding]; other site 482957002759 active site 482957002760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957002761 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 482957002762 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 482957002763 Predicted transcriptional regulator [Transcription]; Region: COG3355 482957002764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957002765 putative DNA binding site [nucleotide binding]; other site 482957002766 putative Zn2+ binding site [ion binding]; other site 482957002767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957002768 Coenzyme A binding pocket [chemical binding]; other site 482957002769 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 482957002770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957002771 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957002772 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957002773 eyelet of channel; other site 482957002774 trimer interface [polypeptide binding]; other site 482957002775 Tannase and feruloyl esterase; Region: Tannase; pfam07519 482957002776 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 482957002777 hypothetical protein; Provisional; Region: PRK09262 482957002778 hypothetical protein; Validated; Region: PRK06201 482957002779 Amidohydrolase; Region: Amidohydro_2; pfam04909 482957002780 benzoate transport; Region: 2A0115; TIGR00895 482957002781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002782 putative substrate translocation pore; other site 482957002783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002784 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 482957002785 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 482957002786 putative active site [active] 482957002787 Fe(II) binding site [ion binding]; other site 482957002788 putative dimer interface [polypeptide binding]; other site 482957002789 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 482957002790 putative dimer interface [polypeptide binding]; other site 482957002791 putative N- and C-terminal domain interface [polypeptide binding]; other site 482957002792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002794 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 482957002795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002796 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957002797 dimerization interface [polypeptide binding]; other site 482957002798 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957002799 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 482957002800 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 482957002801 benzoate transport; Region: 2A0115; TIGR00895 482957002802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002803 putative substrate translocation pore; other site 482957002804 H-NS histone family; Region: Histone_HNS; pfam00816 482957002805 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957002806 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 482957002807 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 482957002808 putative active site [active] 482957002809 putative NTP binding site [chemical binding]; other site 482957002810 putative nucleic acid binding site [nucleotide binding]; other site 482957002811 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 482957002812 Cytochrome P450; Region: p450; cl12078 482957002813 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957002814 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 482957002815 FMN-binding pocket [chemical binding]; other site 482957002816 flavin binding motif; other site 482957002817 phosphate binding motif [ion binding]; other site 482957002818 beta-alpha-beta structure motif; other site 482957002819 NAD binding pocket [chemical binding]; other site 482957002820 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957002821 catalytic loop [active] 482957002822 iron binding site [ion binding]; other site 482957002823 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957002824 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957002825 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957002826 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957002827 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957002828 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957002829 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 482957002830 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 482957002831 active site 482957002832 putative substrate binding pocket [chemical binding]; other site 482957002833 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957002834 short chain dehydrogenase; Provisional; Region: PRK12828 482957002835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957002836 NAD(P) binding site [chemical binding]; other site 482957002837 active site 482957002838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002839 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957002840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002841 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957002842 classical (c) SDRs; Region: SDR_c; cd05233 482957002843 NAD(P) binding site [chemical binding]; other site 482957002844 active site 482957002845 Cupin; Region: Cupin_6; pfam12852 482957002846 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957002847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957002848 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 482957002849 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957002850 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 482957002851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957002852 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 482957002853 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957002854 Walker A/P-loop; other site 482957002855 ATP binding site [chemical binding]; other site 482957002856 Q-loop/lid; other site 482957002857 ABC transporter signature motif; other site 482957002858 Walker B; other site 482957002859 D-loop; other site 482957002860 H-loop/switch region; other site 482957002861 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 482957002862 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957002863 Walker A/P-loop; other site 482957002864 ATP binding site [chemical binding]; other site 482957002865 Q-loop/lid; other site 482957002866 ABC transporter signature motif; other site 482957002867 Walker B; other site 482957002868 D-loop; other site 482957002869 H-loop/switch region; other site 482957002870 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 482957002871 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957002872 TM-ABC transporter signature motif; other site 482957002873 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957002874 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957002875 TM-ABC transporter signature motif; other site 482957002876 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 482957002877 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 482957002878 putative ligand binding site [chemical binding]; other site 482957002879 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 482957002880 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957002881 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957002882 dimer interface [polypeptide binding]; other site 482957002883 putative CheW interface [polypeptide binding]; other site 482957002884 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 482957002885 putative active site [active] 482957002886 Zn binding site [ion binding]; other site 482957002887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002888 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957002889 putative substrate translocation pore; other site 482957002890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957002891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002892 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957002893 dimerization interface [polypeptide binding]; other site 482957002894 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 482957002895 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 482957002896 NADP binding site [chemical binding]; other site 482957002897 active site 482957002898 putative substrate binding site [chemical binding]; other site 482957002899 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 482957002900 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 482957002901 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957002902 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957002903 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957002904 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957002905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 482957002906 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957002907 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957002908 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957002909 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957002910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 482957002911 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957002912 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 482957002913 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957002914 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957002915 PAAR motif; Region: PAAR_motif; pfam05488 482957002916 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 482957002917 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 482957002918 Predicted membrane protein [Function unknown]; Region: COG2259 482957002919 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 482957002920 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957002921 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 482957002922 inhibitor site; inhibition site 482957002923 active site 482957002924 dimer interface [polypeptide binding]; other site 482957002925 catalytic residue [active] 482957002926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957002927 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 482957002928 putative substrate translocation pore; other site 482957002929 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957002930 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 482957002931 substrate binding site [chemical binding]; other site 482957002932 dimer interface [polypeptide binding]; other site 482957002933 ATP binding site [chemical binding]; other site 482957002934 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957002935 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957002936 DNA binding site [nucleotide binding] 482957002937 domain linker motif; other site 482957002938 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 482957002939 putative dimerization interface [polypeptide binding]; other site 482957002940 putative ligand binding site [chemical binding]; other site 482957002941 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 482957002942 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 482957002943 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 482957002944 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 482957002945 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 482957002946 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 482957002947 active site 482957002948 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 482957002949 Na binding site [ion binding]; other site 482957002950 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 482957002951 EBNA-3B; Provisional; Region: PHA03378 482957002952 Fic family protein [Function unknown]; Region: COG3177 482957002953 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 482957002954 Fic/DOC family; Region: Fic; pfam02661 482957002955 LysR family transcriptional regulator; Provisional; Region: PRK14997 482957002956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002957 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957002958 putative effector binding pocket; other site 482957002959 dimerization interface [polypeptide binding]; other site 482957002960 Pirin-related protein [General function prediction only]; Region: COG1741 482957002961 Pirin; Region: Pirin; pfam02678 482957002962 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 482957002963 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957002964 LrgB-like family; Region: LrgB; pfam04172 482957002965 LrgA family; Region: LrgA; pfam03788 482957002966 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 482957002967 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957002968 kynureninase; Region: kynureninase; TIGR01814 482957002969 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957002970 catalytic residue [active] 482957002971 Amidohydrolase; Region: Amidohydro_2; pfam04909 482957002972 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 482957002973 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957002974 homotrimer interaction site [polypeptide binding]; other site 482957002975 putative active site [active] 482957002976 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 482957002977 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 482957002978 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 482957002979 active site 482957002980 catalytic residues [active] 482957002981 metal binding site [ion binding]; metal-binding site 482957002982 DmpG-like communication domain; Region: DmpG_comm; pfam07836 482957002983 acetaldehyde dehydrogenase; Validated; Region: PRK08300 482957002984 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 482957002985 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 482957002986 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 482957002987 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 482957002988 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 482957002989 NAD binding site [chemical binding]; other site 482957002990 catalytic residues [active] 482957002991 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 482957002992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957002993 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957002994 dimerization interface [polypeptide binding]; other site 482957002995 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 482957002996 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957002997 Walker A/P-loop; other site 482957002998 ATP binding site [chemical binding]; other site 482957002999 Q-loop/lid; other site 482957003000 ABC transporter signature motif; other site 482957003001 Walker B; other site 482957003002 D-loop; other site 482957003003 H-loop/switch region; other site 482957003004 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957003005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957003006 dimer interface [polypeptide binding]; other site 482957003007 conserved gate region; other site 482957003008 putative PBP binding loops; other site 482957003009 ABC-ATPase subunit interface; other site 482957003010 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 482957003011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957003012 active site 482957003013 metal binding site [ion binding]; metal-binding site 482957003014 NMT1/THI5 like; Region: NMT1; pfam09084 482957003015 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 482957003016 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957003017 Transcriptional regulators [Transcription]; Region: GntR; COG1802 482957003018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957003019 DNA-binding site [nucleotide binding]; DNA binding site 482957003020 FCD domain; Region: FCD; pfam07729 482957003021 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 482957003022 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957003023 inhibitor site; inhibition site 482957003024 active site 482957003025 dimer interface [polypeptide binding]; other site 482957003026 catalytic residue [active] 482957003027 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957003028 substrate binding pocket [chemical binding]; other site 482957003029 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957003030 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 482957003031 active site 482957003032 metal binding site [ion binding]; metal-binding site 482957003033 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 482957003034 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 482957003035 NAD binding site [chemical binding]; other site 482957003036 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957003037 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957003038 trimer interface [polypeptide binding]; other site 482957003039 eyelet of channel; other site 482957003040 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957003041 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957003042 eyelet of channel; other site 482957003043 trimer interface [polypeptide binding]; other site 482957003044 Cytochrome c; Region: Cytochrom_C; cl11414 482957003045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957003046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957003047 ATP binding site [chemical binding]; other site 482957003048 Mg2+ binding site [ion binding]; other site 482957003049 G-X-G motif; other site 482957003050 transcriptional activator FlhC; Provisional; Region: PRK12860 482957003051 transcriptional activator FlhD; Provisional; Region: PRK02909 482957003052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957003053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957003054 active site 482957003055 phosphorylation site [posttranslational modification] 482957003056 intermolecular recognition site; other site 482957003057 dimerization interface [polypeptide binding]; other site 482957003058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957003059 DNA binding residues [nucleotide binding] 482957003060 dimerization interface [polypeptide binding]; other site 482957003061 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 482957003062 GAF domain; Region: GAF; pfam01590 482957003063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957003064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957003065 dimer interface [polypeptide binding]; other site 482957003066 phosphorylation site [posttranslational modification] 482957003067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957003068 ATP binding site [chemical binding]; other site 482957003069 Mg2+ binding site [ion binding]; other site 482957003070 G-X-G motif; other site 482957003071 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 482957003072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957003073 active site 482957003074 phosphorylation site [posttranslational modification] 482957003075 intermolecular recognition site; other site 482957003076 dimerization interface [polypeptide binding]; other site 482957003077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957003078 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957003079 substrate binding pocket [chemical binding]; other site 482957003080 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957003081 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 482957003082 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957003083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957003084 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957003085 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957003086 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 482957003087 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957003088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957003089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957003090 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 482957003091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957003092 Walker A/P-loop; other site 482957003093 ATP binding site [chemical binding]; other site 482957003094 Q-loop/lid; other site 482957003095 ABC transporter signature motif; other site 482957003096 Walker B; other site 482957003097 D-loop; other site 482957003098 H-loop/switch region; other site 482957003099 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 482957003100 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 482957003101 NAD(P) binding site [chemical binding]; other site 482957003102 catalytic residues [active] 482957003103 amidase; Provisional; Region: PRK07487 482957003104 Amidase; Region: Amidase; cl11426 482957003105 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 482957003106 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957003107 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957003108 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 482957003109 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 482957003110 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957003111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957003112 dimer interface [polypeptide binding]; other site 482957003113 conserved gate region; other site 482957003114 putative PBP binding loops; other site 482957003115 ABC-ATPase subunit interface; other site 482957003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957003117 dimer interface [polypeptide binding]; other site 482957003118 conserved gate region; other site 482957003119 putative PBP binding loops; other site 482957003120 ABC-ATPase subunit interface; other site 482957003121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957003122 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 482957003123 Walker A/P-loop; other site 482957003124 ATP binding site [chemical binding]; other site 482957003125 Q-loop/lid; other site 482957003126 ABC transporter signature motif; other site 482957003127 Walker B; other site 482957003128 D-loop; other site 482957003129 H-loop/switch region; other site 482957003130 TOBE domain; Region: TOBE_2; pfam08402 482957003131 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 482957003132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957003133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957003134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957003135 DNA binding residues [nucleotide binding] 482957003136 dimerization interface [polypeptide binding]; other site 482957003137 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957003138 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957003139 trimer interface [polypeptide binding]; other site 482957003140 eyelet of channel; other site 482957003141 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957003142 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 482957003143 putative C-terminal domain interface [polypeptide binding]; other site 482957003144 putative GSH binding site (G-site) [chemical binding]; other site 482957003145 putative dimer interface [polypeptide binding]; other site 482957003146 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 482957003147 putative N-terminal domain interface [polypeptide binding]; other site 482957003148 putative dimer interface [polypeptide binding]; other site 482957003149 putative substrate binding pocket (H-site) [chemical binding]; other site 482957003150 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957003151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957003152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957003153 dimerization interface [polypeptide binding]; other site 482957003154 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 482957003155 EamA-like transporter family; Region: EamA; pfam00892 482957003156 EamA-like transporter family; Region: EamA; pfam00892 482957003157 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957003158 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957003159 dimerization interface [polypeptide binding]; other site 482957003160 ligand binding site [chemical binding]; other site 482957003161 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957003162 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 482957003163 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957003164 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 482957003165 conserved cys residue [active] 482957003166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957003167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957003168 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 482957003169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957003170 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957003171 dimerization interface [polypeptide binding]; other site 482957003172 substrate binding pocket [chemical binding]; other site 482957003173 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 482957003174 active site 482957003175 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 482957003176 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957003177 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957003178 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957003179 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 482957003180 FMN-binding pocket [chemical binding]; other site 482957003181 flavin binding motif; other site 482957003182 phosphate binding motif [ion binding]; other site 482957003183 beta-alpha-beta structure motif; other site 482957003184 NAD binding pocket [chemical binding]; other site 482957003185 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957003186 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 482957003187 catalytic loop [active] 482957003188 iron binding site [ion binding]; other site 482957003189 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 482957003190 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957003191 NAD(P) binding site [chemical binding]; other site 482957003192 catalytic residues [active] 482957003193 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 482957003194 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957003195 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957003196 [2Fe-2S] cluster binding site [ion binding]; other site 482957003197 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 482957003198 putative alpha subunit interface [polypeptide binding]; other site 482957003199 putative active site [active] 482957003200 putative substrate binding site [chemical binding]; other site 482957003201 Fe binding site [ion binding]; other site 482957003202 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957003203 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 482957003204 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957003205 FAD binding domain; Region: FAD_binding_4; pfam01565 482957003206 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 482957003207 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957003208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957003209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957003210 dimerization interface [polypeptide binding]; other site 482957003211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957003212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957003213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957003214 dimerization interface [polypeptide binding]; other site 482957003215 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957003216 Epoxide hydrolase N terminus; Region: EHN; pfam06441 482957003217 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957003218 Predicted permeases [General function prediction only]; Region: COG0730 482957003219 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957003220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957003221 DNA-binding site [nucleotide binding]; DNA binding site 482957003222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957003223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957003224 homodimer interface [polypeptide binding]; other site 482957003225 catalytic residue [active] 482957003226 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 482957003227 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 482957003228 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 482957003229 Flavin binding site [chemical binding]; other site 482957003230 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 482957003231 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 482957003232 active site 482957003233 dimer interface [polypeptide binding]; other site 482957003234 non-prolyl cis peptide bond; other site 482957003235 insertion regions; other site 482957003236 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957003237 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 482957003238 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 482957003239 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 482957003240 Flavin binding site [chemical binding]; other site 482957003241 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 482957003242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957003243 Walker A motif; other site 482957003244 ATP binding site [chemical binding]; other site 482957003245 Walker B motif; other site 482957003246 arginine finger; other site 482957003247 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957003248 dihydroxyacetone kinase; Provisional; Region: PRK14479 482957003249 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 482957003250 DAK2 domain; Region: Dak2; pfam02734 482957003251 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 482957003252 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 482957003253 Uncharacterized conserved protein [Function unknown]; Region: COG3777 482957003254 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 482957003255 active site 2 [active] 482957003256 active site 1 [active] 482957003257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957003258 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 482957003259 Fusaric acid resistance protein family; Region: FUSC; pfam04632 482957003260 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 482957003261 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 482957003262 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 482957003263 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957003264 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957003265 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957003266 TOBE domain; Region: TOBE; cl01440 482957003267 TOBE domain; Region: TOBE; cl01440 482957003268 NifQ; Region: NifQ; pfam04891 482957003269 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 482957003270 dimer interface [polypeptide binding]; other site 482957003271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957003272 ligand binding site [chemical binding]; other site 482957003273 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957003274 ProQ/FINO family; Region: ProQ; pfam04352 482957003275 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 482957003276 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 482957003277 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957003278 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957003279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957003280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957003281 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 482957003282 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 482957003283 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 482957003284 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 482957003285 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957003286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957003287 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 482957003288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957003289 P-loop; other site 482957003290 Magnesium ion binding site [ion binding]; other site 482957003291 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 482957003292 ParB-like nuclease domain; Region: ParB; smart00470 482957003293 Initiator Replication protein; Region: Rep_3; pfam01051 482957003294 DnaA N-terminal domain; Region: DnaA_N; pfam11638 482957003295 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 482957003296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957003297 Walker A motif; other site 482957003298 ATP binding site [chemical binding]; other site 482957003299 Walker B motif; other site 482957003300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 482957003301 arginine finger; other site 482957003302 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 482957003303 DnaA box-binding interface [nucleotide binding]; other site 482957003304 DNA polymerase III subunit beta; Validated; Region: PRK05643 482957003305 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 482957003306 putative DNA binding surface [nucleotide binding]; other site 482957003307 dimer interface [polypeptide binding]; other site 482957003308 beta-clamp/clamp loader binding surface; other site 482957003309 beta-clamp/translesion DNA polymerase binding surface; other site 482957003310 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 482957003311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957003312 ATP binding site [chemical binding]; other site 482957003313 Mg2+ binding site [ion binding]; other site 482957003314 G-X-G motif; other site 482957003315 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 482957003316 anchoring element; other site 482957003317 dimer interface [polypeptide binding]; other site 482957003318 ATP binding site [chemical binding]; other site 482957003319 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 482957003320 active site 482957003321 putative metal-binding site [ion binding]; other site 482957003322 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 482957003323 WYL domain; Region: WYL; pfam13280 482957003324 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 482957003325 PglZ domain; Region: PglZ; pfam08665 482957003326 Methyltransferase domain; Region: Methyltransf_26; pfam13659 482957003327 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 482957003328 AAA-like domain; Region: AAA_10; pfam12846 482957003329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957003330 non-specific DNA binding site [nucleotide binding]; other site 482957003331 salt bridge; other site 482957003332 sequence-specific DNA binding site [nucleotide binding]; other site 482957003333 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 482957003334 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 482957003335 putative heme binding pocket [chemical binding]; other site 482957003336 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957003337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957003338 DNA binding residues [nucleotide binding] 482957003339 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 482957003340 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 482957003341 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 482957003342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957003343 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 482957003344 Uncharacterized conserved protein [Function unknown]; Region: COG2128 482957003345 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957003346 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 482957003347 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 482957003348 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 482957003349 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 482957003350 Restriction endonuclease [Defense mechanisms]; Region: COG3587 482957003351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957003352 ATP binding site [chemical binding]; other site 482957003353 putative Mg++ binding site [ion binding]; other site 482957003354 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 482957003355 DNA methylase; Region: N6_N4_Mtase; pfam01555 482957003356 DNA methylase; Region: N6_N4_Mtase; cl17433 482957003357 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957003358 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957003359 trimer interface [polypeptide binding]; other site 482957003360 eyelet of channel; other site 482957003361 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 482957003362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957003363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957003364 dimer interface [polypeptide binding]; other site 482957003365 phosphorylation site [posttranslational modification] 482957003366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957003367 ATP binding site [chemical binding]; other site 482957003368 Mg2+ binding site [ion binding]; other site 482957003369 G-X-G motif; other site 482957003370 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957003371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957003372 dimer interface [polypeptide binding]; other site 482957003373 conserved gate region; other site 482957003374 putative PBP binding loops; other site 482957003375 ABC-ATPase subunit interface; other site 482957003376 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 482957003377 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957003378 Walker A/P-loop; other site 482957003379 ATP binding site [chemical binding]; other site 482957003380 Q-loop/lid; other site 482957003381 ABC transporter signature motif; other site 482957003382 Walker B; other site 482957003383 D-loop; other site 482957003384 H-loop/switch region; other site 482957003385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 482957003386 NMT1/THI5 like; Region: NMT1; pfam09084 482957003387 membrane-bound complex binding site; other site 482957003388 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 482957003389 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 482957003390 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 482957003391 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 482957003392 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 482957003393 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 482957003394 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 482957003395 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 482957003396 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 482957003397 LrgA family; Region: LrgA; pfam03788 482957003398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957003399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957003400 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 482957003401 putative dimerization interface [polypeptide binding]; other site 482957003402 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957003403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957003404 putative substrate translocation pore; other site 482957003405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957003406 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957003407 MarR family; Region: MarR_2; cl17246 482957003408 CHASE domain; Region: CHASE; cl01369 482957003409 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957003410 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 482957003411 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 482957003412 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 482957003413 GspL periplasmic domain; Region: GspL_C; pfam12693 482957003414 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 482957003415 type II secretion system protein I; Region: gspI; TIGR01707 482957003416 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 482957003417 Type II transport protein GspH; Region: GspH; pfam12019 482957003418 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 482957003419 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 482957003420 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 482957003421 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 482957003422 type II secretion system protein F; Region: GspF; TIGR02120 482957003423 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957003424 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957003425 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 482957003426 type II secretion system protein E; Region: type_II_gspE; TIGR02533 482957003427 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 482957003428 Walker A motif; other site 482957003429 ATP binding site [chemical binding]; other site 482957003430 Walker B motif; other site 482957003431 type II secretion system protein D; Region: type_II_gspD; TIGR02517 482957003432 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 482957003433 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 482957003434 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 482957003435 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 482957003436 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 482957003437 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957003438 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957003439 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957003440 catalytic residue [active] 482957003441 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 482957003442 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 482957003443 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 482957003444 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 482957003445 IHF dimer interface [polypeptide binding]; other site 482957003446 IHF - DNA interface [nucleotide binding]; other site 482957003447 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 482957003448 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 482957003449 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957003450 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 482957003451 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 482957003452 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 482957003453 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 482957003454 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957003455 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957003456 putative DNA binding site [nucleotide binding]; other site 482957003457 putative Zn2+ binding site [ion binding]; other site 482957003458 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 482957003459 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 482957003460 catalytic triad [active] 482957003461 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957003462 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 482957003463 active site 482957003464 FMN binding site [chemical binding]; other site 482957003465 substrate binding site [chemical binding]; other site 482957003466 homotetramer interface [polypeptide binding]; other site 482957003467 catalytic residue [active] 482957003468 Proteins containing SET domain [General function prediction only]; Region: COG2940 482957003469 SET domain; Region: SET; pfam00856 482957003470 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 482957003471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957003472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957003473 dimer interface [polypeptide binding]; other site 482957003474 phosphorylation site [posttranslational modification] 482957003475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957003476 ATP binding site [chemical binding]; other site 482957003477 Mg2+ binding site [ion binding]; other site 482957003478 G-X-G motif; other site 482957003479 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957003480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957003481 active site 482957003482 phosphorylation site [posttranslational modification] 482957003483 intermolecular recognition site; other site 482957003484 dimerization interface [polypeptide binding]; other site 482957003485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957003486 DNA binding site [nucleotide binding] 482957003487 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 482957003488 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 482957003489 aromatic arch; other site 482957003490 DCoH dimer interaction site [polypeptide binding]; other site 482957003491 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 482957003492 DCoH tetramer interaction site [polypeptide binding]; other site 482957003493 substrate binding site [chemical binding]; other site 482957003494 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 482957003495 cofactor binding site; other site 482957003496 metal binding site [ion binding]; metal-binding site 482957003497 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957003498 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 482957003499 putative DNA binding site [nucleotide binding]; other site 482957003500 putative Zn2+ binding site [ion binding]; other site 482957003501 AsnC family; Region: AsnC_trans_reg; pfam01037 482957003502 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 482957003503 putative active site [active] 482957003504 putative metal binding residues [ion binding]; other site 482957003505 signature motif; other site 482957003506 putative triphosphate binding site [ion binding]; other site 482957003507 dimer interface [polypeptide binding]; other site 482957003508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957003509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957003510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957003511 dimerization interface [polypeptide binding]; other site 482957003512 choline dehydrogenase; Validated; Region: PRK02106 482957003513 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957003514 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 482957003515 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957003516 Walker A/P-loop; other site 482957003517 ATP binding site [chemical binding]; other site 482957003518 Q-loop/lid; other site 482957003519 ABC transporter signature motif; other site 482957003520 Walker B; other site 482957003521 D-loop; other site 482957003522 H-loop/switch region; other site 482957003523 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 482957003524 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957003525 Walker A/P-loop; other site 482957003526 ATP binding site [chemical binding]; other site 482957003527 Q-loop/lid; other site 482957003528 ABC transporter signature motif; other site 482957003529 Walker B; other site 482957003530 D-loop; other site 482957003531 H-loop/switch region; other site 482957003532 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 482957003533 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 482957003534 putative ligand binding site [chemical binding]; other site 482957003535 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957003536 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957003537 TM-ABC transporter signature motif; other site 482957003538 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 482957003539 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957003540 TM-ABC transporter signature motif; other site 482957003541 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957003542 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 482957003543 putative ligand binding site [chemical binding]; other site 482957003544 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957003545 TM-ABC transporter signature motif; other site 482957003546 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 482957003547 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957003548 TM-ABC transporter signature motif; other site 482957003549 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 482957003550 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957003551 Walker A/P-loop; other site 482957003552 ATP binding site [chemical binding]; other site 482957003553 Q-loop/lid; other site 482957003554 ABC transporter signature motif; other site 482957003555 Walker B; other site 482957003556 D-loop; other site 482957003557 H-loop/switch region; other site 482957003558 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 482957003559 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957003560 Walker A/P-loop; other site 482957003561 ATP binding site [chemical binding]; other site 482957003562 Q-loop/lid; other site 482957003563 ABC transporter signature motif; other site 482957003564 Walker B; other site 482957003565 D-loop; other site 482957003566 H-loop/switch region; other site 482957003567 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 482957003568 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 482957003569 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 482957003570 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 482957003571 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 482957003572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957003573 S-adenosylmethionine binding site [chemical binding]; other site 482957003574 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 482957003575 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957003576 P-loop; other site 482957003577 Magnesium ion binding site [ion binding]; other site 482957003578 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957003579 Magnesium ion binding site [ion binding]; other site 482957003580 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 482957003581 ParB-like nuclease domain; Region: ParBc; pfam02195 482957003582 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 482957003583 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 482957003584 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 482957003585 ATP synthase I chain; Region: ATP_synt_I; cl09170 482957003586 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 482957003587 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 482957003588 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 482957003589 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 482957003590 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 482957003591 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 482957003592 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 482957003593 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 482957003594 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 482957003595 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 482957003596 beta subunit interaction interface [polypeptide binding]; other site 482957003597 Walker A motif; other site 482957003598 ATP binding site [chemical binding]; other site 482957003599 Walker B motif; other site 482957003600 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 482957003601 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 482957003602 core domain interface [polypeptide binding]; other site 482957003603 delta subunit interface [polypeptide binding]; other site 482957003604 epsilon subunit interface [polypeptide binding]; other site 482957003605 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 482957003606 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 482957003607 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 482957003608 alpha subunit interaction interface [polypeptide binding]; other site 482957003609 Walker A motif; other site 482957003610 ATP binding site [chemical binding]; other site 482957003611 Walker B motif; other site 482957003612 inhibitor binding site; inhibition site 482957003613 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 482957003614 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 482957003615 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 482957003616 gamma subunit interface [polypeptide binding]; other site 482957003617 epsilon subunit interface [polypeptide binding]; other site 482957003618 LBP interface [polypeptide binding]; other site 482957003619 AMP-binding domain protein; Validated; Region: PRK08315 482957003620 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957003621 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 482957003622 acyl-activating enzyme (AAE) consensus motif; other site 482957003623 putative AMP binding site [chemical binding]; other site 482957003624 putative active site [active] 482957003625 putative CoA binding site [chemical binding]; other site 482957003626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957003627 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957003628 substrate binding pocket [chemical binding]; other site 482957003629 membrane-bound complex binding site; other site 482957003630 hinge residues; other site 482957003631 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 482957003632 substrate binding site [chemical binding]; other site 482957003633 active site 482957003634 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 482957003635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957003636 ATP binding site [chemical binding]; other site 482957003637 putative Mg++ binding site [ion binding]; other site 482957003638 helicase superfamily c-terminal domain; Region: HELICc; smart00490 482957003639 nucleotide binding region [chemical binding]; other site 482957003640 ATP-binding site [chemical binding]; other site 482957003641 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 482957003642 Predicted transcriptional regulator [Transcription]; Region: COG3905 482957003643 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 482957003644 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 482957003645 Glutamate binding site [chemical binding]; other site 482957003646 NAD binding site [chemical binding]; other site 482957003647 catalytic residues [active] 482957003648 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957003649 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957003650 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957003651 dimerization interface [polypeptide binding]; other site 482957003652 ligand binding site [chemical binding]; other site 482957003653 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 482957003654 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957003655 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 482957003656 acyl-activating enzyme (AAE) consensus motif; other site 482957003657 acyl-activating enzyme (AAE) consensus motif; other site 482957003658 putative AMP binding site [chemical binding]; other site 482957003659 putative active site [active] 482957003660 putative CoA binding site [chemical binding]; other site 482957003661 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 482957003662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957003663 active site 482957003664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957003665 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957003666 putative aminotransferase; Provisional; Region: PRK12414 482957003667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957003668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957003669 homodimer interface [polypeptide binding]; other site 482957003670 catalytic residue [active] 482957003671 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 482957003672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957003673 substrate binding pocket [chemical binding]; other site 482957003674 membrane-bound complex binding site; other site 482957003675 hinge residues; other site 482957003676 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957003677 FAD binding domain; Region: FAD_binding_4; pfam01565 482957003678 Transcriptional regulator PadR-like family; Region: PadR; cl17335 482957003679 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 482957003680 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 482957003681 DNA binding residues [nucleotide binding] 482957003682 dimer interface [polypeptide binding]; other site 482957003683 putative metal binding site [ion binding]; other site 482957003684 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 482957003685 Heavy-metal-associated domain; Region: HMA; pfam00403 482957003686 metal-binding site [ion binding] 482957003687 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 482957003688 Double zinc ribbon; Region: DZR; pfam12773 482957003689 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957003690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957003691 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 482957003692 Conserved TM helix; Region: TM_helix; pfam05552 482957003693 Conserved TM helix; Region: TM_helix; pfam05552 482957003694 ethanolamine permease; Region: 2A0305; TIGR00908 482957003695 hypothetical protein; Provisional; Region: PHA02764 482957003696 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 482957003697 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 482957003698 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 482957003699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957003700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957003701 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 482957003702 putative effector binding pocket; other site 482957003703 putative dimerization interface [polypeptide binding]; other site 482957003704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957003705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957003706 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 482957003707 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 482957003708 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957003709 NAD(P) binding site [chemical binding]; other site 482957003710 catalytic residues [active] 482957003711 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 482957003712 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957003713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957003714 thiamine pyrophosphate protein; Validated; Region: PRK08199 482957003715 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957003716 PYR/PP interface [polypeptide binding]; other site 482957003717 dimer interface [polypeptide binding]; other site 482957003718 TPP binding site [chemical binding]; other site 482957003719 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957003720 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 482957003721 TPP-binding site [chemical binding]; other site 482957003722 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 482957003723 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 482957003724 oligomeric interface; other site 482957003725 putative active site [active] 482957003726 homodimer interface [polypeptide binding]; other site 482957003727 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 482957003728 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 482957003729 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 482957003730 Alginate lyase; Region: Alginate_lyase; pfam05426 482957003731 glycine dehydrogenase; Provisional; Region: PRK05367 482957003732 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 482957003733 tetramer interface [polypeptide binding]; other site 482957003734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957003735 catalytic residue [active] 482957003736 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 482957003737 tetramer interface [polypeptide binding]; other site 482957003738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957003739 catalytic residue [active] 482957003740 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 482957003741 lipoyl attachment site [posttranslational modification]; other site 482957003742 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 482957003743 POPLD (NUC188) domain; Region: POPLD; pfam08170 482957003744 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 482957003745 putative oxidoreductase; Provisional; Region: PRK11579 482957003746 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 482957003747 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 482957003748 active site 482957003749 catalytic triad [active] 482957003750 oxyanion hole [active] 482957003751 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 482957003752 Part of AAA domain; Region: AAA_19; pfam13245 482957003753 Family description; Region: UvrD_C_2; pfam13538 482957003754 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 482957003755 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 482957003756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957003757 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957003758 non-specific DNA binding site [nucleotide binding]; other site 482957003759 salt bridge; other site 482957003760 sequence-specific DNA binding site [nucleotide binding]; other site 482957003761 Uncharacterized conserved protein [Function unknown]; Region: COG4278 482957003762 TIGR04222 domain; Region: near_uncomplex 482957003763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957003764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957003765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957003766 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957003767 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 482957003768 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 482957003769 inhibitor-cofactor binding pocket; inhibition site 482957003770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957003771 catalytic residue [active] 482957003772 WbqC-like protein family; Region: WbqC; pfam08889 482957003773 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957003774 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957003775 TPR repeat; Region: TPR_11; pfam13414 482957003776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003777 binding surface 482957003778 TPR motif; other site 482957003779 TPR repeat; Region: TPR_11; pfam13414 482957003780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003781 binding surface 482957003782 TPR motif; other site 482957003783 Tetratricopeptide repeat; Region: TPR_16; pfam13432 482957003784 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957003785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003786 TPR motif; other site 482957003787 Tetratricopeptide repeat; Region: TPR_12; pfam13424 482957003788 binding surface 482957003789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003790 binding surface 482957003791 TPR motif; other site 482957003792 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 482957003793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003794 binding surface 482957003795 TPR motif; other site 482957003796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003797 TPR motif; other site 482957003798 binding surface 482957003799 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957003800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003801 TPR motif; other site 482957003802 binding surface 482957003803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 482957003804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003805 binding surface 482957003806 TPR motif; other site 482957003807 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 482957003808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003809 binding surface 482957003810 TPR motif; other site 482957003811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003812 TPR motif; other site 482957003813 binding surface 482957003814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957003815 binding surface 482957003816 TPR motif; other site 482957003817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 482957003818 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957003819 Flagellar protein FliT; Region: FliT; pfam05400 482957003820 flagellar capping protein; Reviewed; Region: fliD; PRK08032 482957003821 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 482957003822 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 482957003823 flagellin; Provisional; Region: PRK12802 482957003824 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 482957003825 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 482957003826 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 482957003827 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957003828 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957003829 N-terminal plug; other site 482957003830 ligand-binding site [chemical binding]; other site 482957003831 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 482957003832 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 482957003833 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 482957003834 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 482957003835 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 482957003836 putative hydrolase; Provisional; Region: PRK10976 482957003837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957003838 active site 482957003839 motif I; other site 482957003840 motif II; other site 482957003841 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 482957003842 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 482957003843 amphipathic channel; other site 482957003844 Asn-Pro-Ala signature motifs; other site 482957003845 H-NS histone family; Region: Histone_HNS; pfam00816 482957003846 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957003847 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957003848 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 482957003849 putative ADP-binding pocket [chemical binding]; other site 482957003850 transcriptional activator FlhD; Provisional; Region: PRK02909 482957003851 transcriptional activator FlhC; Provisional; Region: PRK12722 482957003852 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 482957003853 flagellar motor protein MotA; Validated; Region: PRK09110 482957003854 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 482957003855 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 482957003856 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957003857 ligand binding site [chemical binding]; other site 482957003858 Response regulator receiver domain; Region: Response_reg; pfam00072 482957003859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957003860 active site 482957003861 phosphorylation site [posttranslational modification] 482957003862 intermolecular recognition site; other site 482957003863 dimerization interface [polypeptide binding]; other site 482957003864 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 482957003865 putative binding surface; other site 482957003866 active site 482957003867 CheY binding; Region: CheY-binding; pfam09078 482957003868 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 482957003869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957003870 ATP binding site [chemical binding]; other site 482957003871 Mg2+ binding site [ion binding]; other site 482957003872 G-X-G motif; other site 482957003873 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 482957003874 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 482957003875 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 482957003876 dimer interface [polypeptide binding]; other site 482957003877 ligand binding site [chemical binding]; other site 482957003878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957003879 dimerization interface [polypeptide binding]; other site 482957003880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957003881 dimer interface [polypeptide binding]; other site 482957003882 putative CheW interface [polypeptide binding]; other site 482957003883 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 482957003884 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 482957003885 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 482957003886 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 482957003887 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 482957003888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957003889 active site 482957003890 phosphorylation site [posttranslational modification] 482957003891 intermolecular recognition site; other site 482957003892 dimerization interface [polypeptide binding]; other site 482957003893 CheB methylesterase; Region: CheB_methylest; pfam01339 482957003894 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 482957003895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957003896 active site 482957003897 phosphorylation site [posttranslational modification] 482957003898 intermolecular recognition site; other site 482957003899 dimerization interface [polypeptide binding]; other site 482957003900 chemotaxis regulator CheZ; Provisional; Region: PRK11166 482957003901 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 482957003902 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 482957003903 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 482957003904 dimer interface [polypeptide binding]; other site 482957003905 Protein of unknown function (DUF805); Region: DUF805; pfam05656 482957003906 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 482957003907 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 482957003908 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 482957003909 FHIPEP family; Region: FHIPEP; pfam00771 482957003910 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 482957003911 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 482957003912 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 482957003913 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 482957003914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957003915 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 482957003916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957003917 DNA binding residues [nucleotide binding] 482957003918 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 482957003919 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 482957003920 homotetramer interface [polypeptide binding]; other site 482957003921 ligand binding site [chemical binding]; other site 482957003922 catalytic site [active] 482957003923 NAD binding site [chemical binding]; other site 482957003924 Predicted membrane protein [Function unknown]; Region: COG1950 482957003925 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 482957003926 FAD binding site [chemical binding]; other site 482957003927 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 482957003928 Amidase; Region: Amidase; cl11426 482957003929 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 482957003930 Nitronate monooxygenase; Region: NMO; pfam03060 482957003931 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957003932 FMN binding site [chemical binding]; other site 482957003933 substrate binding site [chemical binding]; other site 482957003934 putative catalytic residue [active] 482957003935 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957003936 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957003937 dimerization interface [polypeptide binding]; other site 482957003938 ligand binding site [chemical binding]; other site 482957003939 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 482957003940 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 482957003941 H-NS histone family; Region: Histone_HNS; pfam00816 482957003942 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957003943 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 482957003944 Cation efflux family; Region: Cation_efflux; pfam01545 482957003945 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957003946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957003947 putative DNA binding site [nucleotide binding]; other site 482957003948 putative Zn2+ binding site [ion binding]; other site 482957003949 AsnC family; Region: AsnC_trans_reg; pfam01037 482957003950 active site 482957003951 catalytic site [active] 482957003952 substrate binding site [chemical binding]; other site 482957003953 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 482957003954 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 482957003955 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 482957003956 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 482957003957 Predicted methyltransferases [General function prediction only]; Region: COG0313 482957003958 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 482957003959 putative SAM binding site [chemical binding]; other site 482957003960 putative homodimer interface [polypeptide binding]; other site 482957003961 hypothetical protein; Provisional; Region: PRK14673 482957003962 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 482957003963 active site 482957003964 dimer interface [polypeptide binding]; other site 482957003965 outer membrane lipoprotein; Provisional; Region: PRK11023 482957003966 BON domain; Region: BON; pfam04972 482957003967 BON domain; Region: BON; cl02771 482957003968 Cytochrome c; Region: Cytochrom_C; cl11414 482957003969 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 482957003970 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 482957003971 active site 482957003972 tetramer interface [polypeptide binding]; other site 482957003973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957003974 D-galactonate transporter; Region: 2A0114; TIGR00893 482957003975 putative substrate translocation pore; other site 482957003976 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 482957003977 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 482957003978 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 482957003979 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 482957003980 FtsX-like permease family; Region: FtsX; pfam02687 482957003981 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 482957003982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 482957003983 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 482957003984 Walker A/P-loop; other site 482957003985 ATP binding site [chemical binding]; other site 482957003986 Q-loop/lid; other site 482957003987 ABC transporter signature motif; other site 482957003988 Walker B; other site 482957003989 D-loop; other site 482957003990 H-loop/switch region; other site 482957003991 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 482957003992 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957003993 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 482957003994 Uncharacterized conserved protein [Function unknown]; Region: COG1656 482957003995 Protein of unknown function DUF82; Region: DUF82; pfam01927 482957003996 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957003997 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957003998 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957003999 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957004000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957004001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957004002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957004003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957004004 dimerization interface [polypeptide binding]; other site 482957004005 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 482957004006 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 482957004007 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 482957004008 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 482957004009 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 482957004010 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 482957004011 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957004012 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 482957004013 substrate binding site [chemical binding]; other site 482957004014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957004015 active site 482957004016 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 482957004017 Malic enzyme, N-terminal domain; Region: malic; pfam00390 482957004018 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 482957004019 putative NAD(P) binding site [chemical binding]; other site 482957004020 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 482957004021 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 482957004022 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 482957004023 dimer interface [polypeptide binding]; other site 482957004024 PYR/PP interface [polypeptide binding]; other site 482957004025 TPP binding site [chemical binding]; other site 482957004026 substrate binding site [chemical binding]; other site 482957004027 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 482957004028 TPP-binding site; other site 482957004029 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 482957004030 Sfi1 spindle body protein; Region: Sfi1; pfam08457 482957004031 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 482957004032 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 482957004033 dimer interface [polypeptide binding]; other site 482957004034 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 482957004035 active site 482957004036 Fe binding site [ion binding]; other site 482957004037 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957004038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957004039 putative DNA binding site [nucleotide binding]; other site 482957004040 putative Zn2+ binding site [ion binding]; other site 482957004041 AsnC family; Region: AsnC_trans_reg; pfam01037 482957004042 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957004043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957004044 Coenzyme A binding pocket [chemical binding]; other site 482957004045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957004046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957004047 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 482957004048 Protein of unknown function; Region: DUF3658; pfam12395 482957004049 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 482957004050 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 482957004051 FAD binding pocket [chemical binding]; other site 482957004052 FAD binding motif [chemical binding]; other site 482957004053 phosphate binding motif [ion binding]; other site 482957004054 beta-alpha-beta structure motif; other site 482957004055 NAD(p) ribose binding residues [chemical binding]; other site 482957004056 NAD binding pocket [chemical binding]; other site 482957004057 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 482957004058 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957004059 catalytic loop [active] 482957004060 iron binding site [ion binding]; other site 482957004061 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 482957004062 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 482957004063 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 482957004064 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 482957004065 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 482957004066 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 482957004067 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 482957004068 active site 482957004069 catalytic triad [active] 482957004070 oxyanion hole [active] 482957004071 elongation factor Tu; Reviewed; Region: PRK00049 482957004072 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 482957004073 G1 box; other site 482957004074 GEF interaction site [polypeptide binding]; other site 482957004075 GTP/Mg2+ binding site [chemical binding]; other site 482957004076 Switch I region; other site 482957004077 G2 box; other site 482957004078 G3 box; other site 482957004079 Switch II region; other site 482957004080 G4 box; other site 482957004081 G5 box; other site 482957004082 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 482957004083 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 482957004084 Antibiotic Binding Site [chemical binding]; other site 482957004085 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 482957004086 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 482957004087 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 482957004088 putative homodimer interface [polypeptide binding]; other site 482957004089 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 482957004090 heterodimer interface [polypeptide binding]; other site 482957004091 homodimer interface [polypeptide binding]; other site 482957004092 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 482957004093 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 482957004094 23S rRNA interface [nucleotide binding]; other site 482957004095 L7/L12 interface [polypeptide binding]; other site 482957004096 putative thiostrepton binding site; other site 482957004097 L25 interface [polypeptide binding]; other site 482957004098 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 482957004099 mRNA/rRNA interface [nucleotide binding]; other site 482957004100 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 482957004101 23S rRNA interface [nucleotide binding]; other site 482957004102 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 482957004103 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 482957004104 peripheral dimer interface [polypeptide binding]; other site 482957004105 core dimer interface [polypeptide binding]; other site 482957004106 L10 interface [polypeptide binding]; other site 482957004107 L11 interface [polypeptide binding]; other site 482957004108 putative EF-Tu interaction site [polypeptide binding]; other site 482957004109 putative EF-G interaction site [polypeptide binding]; other site 482957004110 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 482957004111 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 482957004112 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 482957004113 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 482957004114 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 482957004115 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 482957004116 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 482957004117 RPB3 interaction site [polypeptide binding]; other site 482957004118 RPB1 interaction site [polypeptide binding]; other site 482957004119 RPB11 interaction site [polypeptide binding]; other site 482957004120 RPB10 interaction site [polypeptide binding]; other site 482957004121 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 482957004122 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 482957004123 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 482957004124 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 482957004125 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 482957004126 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 482957004127 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 482957004128 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 482957004129 DNA binding site [nucleotide binding] 482957004130 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 482957004131 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 482957004132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957004133 ATP binding site [chemical binding]; other site 482957004134 putative Mg++ binding site [ion binding]; other site 482957004135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957004136 nucleotide binding region [chemical binding]; other site 482957004137 ATP-binding site [chemical binding]; other site 482957004138 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 482957004139 HRDC domain; Region: HRDC; pfam00570 482957004140 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 482957004141 S17 interaction site [polypeptide binding]; other site 482957004142 S8 interaction site; other site 482957004143 16S rRNA interaction site [nucleotide binding]; other site 482957004144 streptomycin interaction site [chemical binding]; other site 482957004145 23S rRNA interaction site [nucleotide binding]; other site 482957004146 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 482957004147 30S ribosomal protein S7; Validated; Region: PRK05302 482957004148 elongation factor G; Reviewed; Region: PRK00007 482957004149 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 482957004150 G1 box; other site 482957004151 putative GEF interaction site [polypeptide binding]; other site 482957004152 GTP/Mg2+ binding site [chemical binding]; other site 482957004153 Switch I region; other site 482957004154 G2 box; other site 482957004155 G3 box; other site 482957004156 Switch II region; other site 482957004157 G4 box; other site 482957004158 G5 box; other site 482957004159 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 482957004160 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 482957004161 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 482957004162 elongation factor Tu; Reviewed; Region: PRK00049 482957004163 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 482957004164 G1 box; other site 482957004165 GEF interaction site [polypeptide binding]; other site 482957004166 GTP/Mg2+ binding site [chemical binding]; other site 482957004167 Switch I region; other site 482957004168 G2 box; other site 482957004169 G3 box; other site 482957004170 Switch II region; other site 482957004171 G4 box; other site 482957004172 G5 box; other site 482957004173 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 482957004174 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 482957004175 Antibiotic Binding Site [chemical binding]; other site 482957004176 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 482957004177 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 482957004178 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 482957004179 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 482957004180 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 482957004181 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 482957004182 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 482957004183 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 482957004184 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 482957004185 putative translocon binding site; other site 482957004186 protein-rRNA interface [nucleotide binding]; other site 482957004187 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 482957004188 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 482957004189 G-X-X-G motif; other site 482957004190 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 482957004191 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 482957004192 23S rRNA interface [nucleotide binding]; other site 482957004193 5S rRNA interface [nucleotide binding]; other site 482957004194 putative antibiotic binding site [chemical binding]; other site 482957004195 L25 interface [polypeptide binding]; other site 482957004196 L27 interface [polypeptide binding]; other site 482957004197 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 482957004198 23S rRNA interface [nucleotide binding]; other site 482957004199 putative translocon interaction site; other site 482957004200 signal recognition particle (SRP54) interaction site; other site 482957004201 L23 interface [polypeptide binding]; other site 482957004202 trigger factor interaction site; other site 482957004203 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 482957004204 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 482957004205 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 482957004206 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 482957004207 RNA binding site [nucleotide binding]; other site 482957004208 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 482957004209 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 482957004210 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 482957004211 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 482957004212 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 482957004213 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 482957004214 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 482957004215 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 482957004216 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 482957004217 5S rRNA interface [nucleotide binding]; other site 482957004218 L27 interface [polypeptide binding]; other site 482957004219 23S rRNA interface [nucleotide binding]; other site 482957004220 L5 interface [polypeptide binding]; other site 482957004221 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 482957004222 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 482957004223 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 482957004224 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 482957004225 23S rRNA binding site [nucleotide binding]; other site 482957004226 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 482957004227 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 482957004228 SecY translocase; Region: SecY; pfam00344 482957004229 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 482957004230 rRNA binding site [nucleotide binding]; other site 482957004231 predicted 30S ribosome binding site; other site 482957004232 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 482957004233 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 482957004234 30S ribosomal protein S13; Region: bact_S13; TIGR03631 482957004235 30S ribosomal protein S11; Validated; Region: PRK05309 482957004236 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 482957004237 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 482957004238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957004239 RNA binding surface [nucleotide binding]; other site 482957004240 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 482957004241 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 482957004242 alphaNTD homodimer interface [polypeptide binding]; other site 482957004243 alphaNTD - beta interaction site [polypeptide binding]; other site 482957004244 alphaNTD - beta' interaction site [polypeptide binding]; other site 482957004245 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 482957004246 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 482957004247 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 482957004248 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 482957004249 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 482957004250 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 482957004251 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 482957004252 DsbD alpha interface [polypeptide binding]; other site 482957004253 catalytic residues [active] 482957004254 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 482957004255 dimer interface [polypeptide binding]; other site 482957004256 active site 482957004257 aspartate-rich active site metal binding site; other site 482957004258 allosteric magnesium binding site [ion binding]; other site 482957004259 Schiff base residues; other site 482957004260 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 482957004261 G1 box; other site 482957004262 GTP/Mg2+ binding site [chemical binding]; other site 482957004263 Switch I region; other site 482957004264 G2 box; other site 482957004265 G3 box; other site 482957004266 Switch II region; other site 482957004267 G4 box; other site 482957004268 G5 box; other site 482957004269 Cytochrome c553 [Energy production and conversion]; Region: COG2863 482957004270 Cytochrome c; Region: Cytochrom_C; cl11414 482957004271 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 482957004272 ResB-like family; Region: ResB; pfam05140 482957004273 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 482957004274 ResB-like family; Region: ResB; pfam05140 482957004275 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 482957004276 TMAO/DMSO reductase; Reviewed; Region: PRK05363 482957004277 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 482957004278 Moco binding site; other site 482957004279 metal coordination site [ion binding]; other site 482957004280 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 482957004281 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 482957004282 putative iron binding site [ion binding]; other site 482957004283 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 482957004284 Transglycosylase; Region: Transgly; pfam00912 482957004285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 482957004286 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 482957004287 Secretin and TonB N terminus short domain; Region: STN; pfam07660 482957004288 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 482957004289 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 482957004290 shikimate kinase; Reviewed; Region: aroK; PRK00131 482957004291 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 482957004292 ADP binding site [chemical binding]; other site 482957004293 magnesium binding site [ion binding]; other site 482957004294 putative shikimate binding site; other site 482957004295 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 482957004296 active site 482957004297 dimer interface [polypeptide binding]; other site 482957004298 metal binding site [ion binding]; metal-binding site 482957004299 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 482957004300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 482957004301 Zn2+ binding site [ion binding]; other site 482957004302 Mg2+ binding site [ion binding]; other site 482957004303 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 482957004304 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 482957004305 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 482957004306 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 482957004307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957004308 dimer interface [polypeptide binding]; other site 482957004309 conserved gate region; other site 482957004310 putative PBP binding loops; other site 482957004311 ABC-ATPase subunit interface; other site 482957004312 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 482957004313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957004314 dimer interface [polypeptide binding]; other site 482957004315 conserved gate region; other site 482957004316 putative PBP binding loops; other site 482957004317 ABC-ATPase subunit interface; other site 482957004318 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 482957004319 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 482957004320 Walker A/P-loop; other site 482957004321 ATP binding site [chemical binding]; other site 482957004322 Q-loop/lid; other site 482957004323 ABC transporter signature motif; other site 482957004324 Walker B; other site 482957004325 D-loop; other site 482957004326 H-loop/switch region; other site 482957004327 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 482957004328 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 482957004329 putative active site [active] 482957004330 catalytic site [active] 482957004331 putative metal binding site [ion binding]; other site 482957004332 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 482957004333 Transposase IS200 like; Region: Y1_Tnp; cl00848 482957004334 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 482957004335 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 482957004336 active site 482957004337 dimer interface [polypeptide binding]; other site 482957004338 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 482957004339 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 482957004340 active site 482957004341 FMN binding site [chemical binding]; other site 482957004342 substrate binding site [chemical binding]; other site 482957004343 3Fe-4S cluster binding site [ion binding]; other site 482957004344 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 482957004345 domain interface; other site 482957004346 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 482957004347 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957004348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957004349 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 482957004350 amino acid carrier protein; Region: agcS; TIGR00835 482957004351 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 482957004352 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 482957004353 benzoate transport; Region: 2A0115; TIGR00895 482957004354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957004355 putative substrate translocation pore; other site 482957004356 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 482957004357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957004358 NAD(P) binding site [chemical binding]; other site 482957004359 active site 482957004360 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 482957004361 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 482957004362 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 482957004363 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 482957004364 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 482957004365 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 482957004366 thiS-thiF/thiG interaction site; other site 482957004367 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 482957004368 ThiS interaction site; other site 482957004369 putative active site [active] 482957004370 tetramer interface [polypeptide binding]; other site 482957004371 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 482957004372 thiamine phosphate binding site [chemical binding]; other site 482957004373 active site 482957004374 pyrophosphate binding site [ion binding]; other site 482957004375 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 482957004376 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 482957004377 Walker A/P-loop; other site 482957004378 ATP binding site [chemical binding]; other site 482957004379 Q-loop/lid; other site 482957004380 ABC transporter signature motif; other site 482957004381 Walker B; other site 482957004382 D-loop; other site 482957004383 H-loop/switch region; other site 482957004384 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 482957004385 Permease; Region: Permease; pfam02405 482957004386 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 482957004387 mce related protein; Region: MCE; pfam02470 482957004388 VacJ like lipoprotein; Region: VacJ; cl01073 482957004389 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 482957004390 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 482957004391 anti sigma factor interaction site; other site 482957004392 regulatory phosphorylation site [posttranslational modification]; other site 482957004393 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 482957004394 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 482957004395 Walker A/P-loop; other site 482957004396 ATP binding site [chemical binding]; other site 482957004397 Q-loop/lid; other site 482957004398 ABC transporter signature motif; other site 482957004399 Walker B; other site 482957004400 D-loop; other site 482957004401 H-loop/switch region; other site 482957004402 ABC-2 type transporter; Region: ABC2_membrane; cl17235 482957004403 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 482957004404 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 482957004405 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 482957004406 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 482957004407 hinge; other site 482957004408 active site 482957004409 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 482957004410 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 482957004411 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 482957004412 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 482957004413 NAD binding site [chemical binding]; other site 482957004414 dimerization interface [polypeptide binding]; other site 482957004415 product binding site; other site 482957004416 substrate binding site [chemical binding]; other site 482957004417 zinc binding site [ion binding]; other site 482957004418 catalytic residues [active] 482957004419 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 482957004420 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957004421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957004422 homodimer interface [polypeptide binding]; other site 482957004423 catalytic residue [active] 482957004424 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 482957004425 putative active site pocket [active] 482957004426 4-fold oligomerization interface [polypeptide binding]; other site 482957004427 metal binding residues [ion binding]; metal-binding site 482957004428 3-fold/trimer interface [polypeptide binding]; other site 482957004429 MarC family integral membrane protein; Region: MarC; cl00919 482957004430 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 482957004431 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 482957004432 putative active site [active] 482957004433 oxyanion strand; other site 482957004434 catalytic triad [active] 482957004435 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 482957004436 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 482957004437 catalytic residues [active] 482957004438 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 482957004439 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 482957004440 substrate binding site [chemical binding]; other site 482957004441 glutamase interaction surface [polypeptide binding]; other site 482957004442 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 482957004443 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 482957004444 metal binding site [ion binding]; metal-binding site 482957004445 Predicted membrane protein [Function unknown]; Region: COG3671 482957004446 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 482957004447 nucleotide binding site/active site [active] 482957004448 HIT family signature motif; other site 482957004449 catalytic residue [active] 482957004450 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 482957004451 sec-independent translocase; Provisional; Region: tatB; PRK01919 482957004452 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 482957004453 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 482957004454 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 482957004455 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957004456 protein binding site [polypeptide binding]; other site 482957004457 Uncharacterized conserved protein [Function unknown]; Region: COG0327 482957004458 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 482957004459 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 482957004460 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 482957004461 [2Fe-2S] cluster binding site [ion binding]; other site 482957004462 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 482957004463 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 482957004464 Qi binding site; other site 482957004465 intrachain domain interface; other site 482957004466 interchain domain interface [polypeptide binding]; other site 482957004467 heme bH binding site [chemical binding]; other site 482957004468 heme bL binding site [chemical binding]; other site 482957004469 Qo binding site; other site 482957004470 interchain domain interface [polypeptide binding]; other site 482957004471 intrachain domain interface; other site 482957004472 Qi binding site; other site 482957004473 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 482957004474 Qo binding site; other site 482957004475 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 482957004476 stringent starvation protein A; Provisional; Region: sspA; PRK09481 482957004477 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 482957004478 C-terminal domain interface [polypeptide binding]; other site 482957004479 putative GSH binding site (G-site) [chemical binding]; other site 482957004480 dimer interface [polypeptide binding]; other site 482957004481 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 482957004482 dimer interface [polypeptide binding]; other site 482957004483 N-terminal domain interface [polypeptide binding]; other site 482957004484 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 482957004485 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 482957004486 Phage integrase protein; Region: DUF3701; pfam12482 482957004487 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 482957004488 LytTr DNA-binding domain; Region: LytTR; smart00850 482957004489 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957004490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957004491 substrate binding pocket [chemical binding]; other site 482957004492 membrane-bound complex binding site; other site 482957004493 hinge residues; other site 482957004494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 482957004495 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957004496 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957004497 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957004498 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957004499 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 482957004500 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 482957004501 RHS Repeat; Region: RHS_repeat; pfam05593 482957004502 RHS Repeat; Region: RHS_repeat; pfam05593 482957004503 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 482957004504 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 482957004505 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 482957004506 RHS Repeat; Region: RHS_repeat; pfam05593 482957004507 RHS protein; Region: RHS; pfam03527 482957004508 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 482957004509 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 482957004510 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 482957004511 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 482957004512 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 482957004513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957004514 TPR motif; other site 482957004515 binding surface 482957004516 Protein of unknown function (DUF770); Region: DUF770; pfam05591 482957004517 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 482957004518 Protein of unknown function (DUF877); Region: DUF877; pfam05943 482957004519 Protein of unknown function (DUF796); Region: DUF796; pfam05638 482957004520 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 482957004521 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 482957004522 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 482957004523 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 482957004524 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 482957004525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957004526 Walker A motif; other site 482957004527 ATP binding site [chemical binding]; other site 482957004528 Walker B motif; other site 482957004529 arginine finger; other site 482957004530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957004531 Walker A motif; other site 482957004532 ATP binding site [chemical binding]; other site 482957004533 Walker B motif; other site 482957004534 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 482957004535 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 482957004536 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 482957004537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 482957004538 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957004539 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957004540 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957004541 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957004542 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 482957004543 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957004544 ligand binding site [chemical binding]; other site 482957004545 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 482957004546 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 482957004547 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 482957004548 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 482957004549 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 482957004550 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 482957004551 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 482957004552 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 482957004553 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 482957004554 Cl binding site [ion binding]; other site 482957004555 oligomer interface [polypeptide binding]; other site 482957004556 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 482957004557 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957004558 NAD(P) binding site [chemical binding]; other site 482957004559 transcriptional activator TtdR; Provisional; Region: PRK09801 482957004560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957004561 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957004562 putative effector binding pocket; other site 482957004563 dimerization interface [polypeptide binding]; other site 482957004564 Peptidase family M1; Region: Peptidase_M1; pfam01433 482957004565 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 482957004566 Zn binding site [ion binding]; other site 482957004567 Water Stress and Hypersensitive response; Region: WHy; smart00769 482957004568 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 482957004569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957004570 S-adenosylmethionine binding site [chemical binding]; other site 482957004571 Methyltransferase domain; Region: Methyltransf_32; pfam13679 482957004572 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 482957004573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957004574 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957004575 D-galactonate transporter; Region: 2A0114; TIGR00893 482957004576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957004577 putative substrate translocation pore; other site 482957004578 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 482957004579 putative FMN binding site [chemical binding]; other site 482957004580 putative chaperone; Provisional; Region: PRK11678 482957004581 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 482957004582 nucleotide binding site [chemical binding]; other site 482957004583 putative NEF/HSP70 interaction site [polypeptide binding]; other site 482957004584 SBD interface [polypeptide binding]; other site 482957004585 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 482957004586 DNA-binding site [nucleotide binding]; DNA binding site 482957004587 RNA-binding motif; other site 482957004588 amino acid transporter; Region: 2A0306; TIGR00909 482957004589 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 482957004590 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 482957004591 putative active site [active] 482957004592 metal binding site [ion binding]; metal-binding site 482957004593 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 482957004594 Flavoprotein; Region: Flavoprotein; pfam02441 482957004595 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 482957004596 putative GSH binding site [chemical binding]; other site 482957004597 catalytic residues [active] 482957004598 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 482957004599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957004600 S-adenosylmethionine binding site [chemical binding]; other site 482957004601 peptide chain release factor 1; Validated; Region: prfA; PRK00591 482957004602 This domain is found in peptide chain release factors; Region: PCRF; smart00937 482957004603 RF-1 domain; Region: RF-1; pfam00472 482957004604 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 482957004605 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 482957004606 tRNA; other site 482957004607 putative tRNA binding site [nucleotide binding]; other site 482957004608 putative NADP binding site [chemical binding]; other site 482957004609 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 482957004610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957004611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957004612 active site 482957004613 phosphorylation site [posttranslational modification] 482957004614 intermolecular recognition site; other site 482957004615 dimerization interface [polypeptide binding]; other site 482957004616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957004617 DNA binding site [nucleotide binding] 482957004618 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 482957004619 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 482957004620 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 482957004621 active site 482957004622 Isochorismatase family; Region: Isochorismatase; pfam00857 482957004623 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 482957004624 catalytic triad [active] 482957004625 conserved cis-peptide bond; other site 482957004626 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 482957004627 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 482957004628 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 482957004629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957004630 Walker A/P-loop; other site 482957004631 ATP binding site [chemical binding]; other site 482957004632 Q-loop/lid; other site 482957004633 ABC transporter signature motif; other site 482957004634 Walker B; other site 482957004635 D-loop; other site 482957004636 H-loop/switch region; other site 482957004637 ABC transporter; Region: ABC_tran_2; pfam12848 482957004638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957004639 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 482957004640 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957004641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957004642 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957004643 dimerization interface [polypeptide binding]; other site 482957004644 substrate binding pocket [chemical binding]; other site 482957004645 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 482957004646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957004647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957004648 putative substrate translocation pore; other site 482957004649 Protein of unknown function (DUF419); Region: DUF419; cl15265 482957004650 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 482957004651 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 482957004652 GTP-binding protein YchF; Reviewed; Region: PRK09601 482957004653 YchF GTPase; Region: YchF; cd01900 482957004654 G1 box; other site 482957004655 GTP/Mg2+ binding site [chemical binding]; other site 482957004656 Switch I region; other site 482957004657 G2 box; other site 482957004658 Switch II region; other site 482957004659 G3 box; other site 482957004660 G4 box; other site 482957004661 G5 box; other site 482957004662 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 482957004663 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 482957004664 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 482957004665 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 482957004666 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 482957004667 dimerization domain [polypeptide binding]; other site 482957004668 dimer interface [polypeptide binding]; other site 482957004669 catalytic residues [active] 482957004670 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 482957004671 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 482957004672 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957004673 azoreductase; Reviewed; Region: PRK00170 482957004674 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957004675 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 482957004676 ligand binding site [chemical binding]; other site 482957004677 active site 482957004678 UGI interface [polypeptide binding]; other site 482957004679 catalytic site [active] 482957004680 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 482957004681 putative active site [active] 482957004682 putative metal binding residues [ion binding]; other site 482957004683 signature motif; other site 482957004684 putative triphosphate binding site [ion binding]; other site 482957004685 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 482957004686 active site 482957004687 ribulose/triose binding site [chemical binding]; other site 482957004688 phosphate binding site [ion binding]; other site 482957004689 substrate (anthranilate) binding pocket [chemical binding]; other site 482957004690 product (indole) binding pocket [chemical binding]; other site 482957004691 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 482957004692 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 482957004693 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 482957004694 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 482957004695 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 482957004696 glutamine binding [chemical binding]; other site 482957004697 catalytic triad [active] 482957004698 anthranilate synthase component I; Provisional; Region: PRK13565 482957004699 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 482957004700 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 482957004701 phosphoglycolate phosphatase; Provisional; Region: PRK13222 482957004702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957004703 motif II; other site 482957004704 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 482957004705 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 482957004706 substrate binding site [chemical binding]; other site 482957004707 hexamer interface [polypeptide binding]; other site 482957004708 metal binding site [ion binding]; metal-binding site 482957004709 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 482957004710 MltA specific insert domain; Region: MltA; smart00925 482957004711 3D domain; Region: 3D; pfam06725 482957004712 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 482957004713 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 482957004714 active site 482957004715 AMP binding site [chemical binding]; other site 482957004716 homodimer interface [polypeptide binding]; other site 482957004717 acyl-activating enzyme (AAE) consensus motif; other site 482957004718 CoA binding site [chemical binding]; other site 482957004719 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 482957004720 CoenzymeA binding site [chemical binding]; other site 482957004721 subunit interaction site [polypeptide binding]; other site 482957004722 PHB binding site; other site 482957004723 enoyl-CoA hydratase; Provisional; Region: PRK08140 482957004724 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957004725 substrate binding site [chemical binding]; other site 482957004726 oxyanion hole (OAH) forming residues; other site 482957004727 trimer interface [polypeptide binding]; other site 482957004728 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 482957004729 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957004730 dimer interface [polypeptide binding]; other site 482957004731 active site 482957004732 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 482957004733 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957004734 NAD(P) binding site [chemical binding]; other site 482957004735 catalytic residues [active] 482957004736 enoyl-CoA hydratase; Provisional; Region: PRK05862 482957004737 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957004738 substrate binding site [chemical binding]; other site 482957004739 oxyanion hole (OAH) forming residues; other site 482957004740 trimer interface [polypeptide binding]; other site 482957004741 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 482957004742 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 482957004743 putative [4Fe-4S] binding site [ion binding]; other site 482957004744 putative molybdopterin cofactor binding site [chemical binding]; other site 482957004745 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 482957004746 putative molybdopterin cofactor binding site; other site 482957004747 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 482957004748 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 482957004749 acyl-activating enzyme (AAE) consensus motif; other site 482957004750 putative AMP binding site [chemical binding]; other site 482957004751 putative active site [active] 482957004752 putative CoA binding site [chemical binding]; other site 482957004753 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957004754 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957004755 trimer interface [polypeptide binding]; other site 482957004756 eyelet of channel; other site 482957004757 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 482957004758 diiron binding motif [ion binding]; other site 482957004759 cell division protein MraZ; Reviewed; Region: PRK00326 482957004760 MraZ protein; Region: MraZ; pfam02381 482957004761 MraZ protein; Region: MraZ; pfam02381 482957004762 MraW methylase family; Region: Methyltransf_5; cl17771 482957004763 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 482957004764 Cell division protein FtsL; Region: FtsL; cl11433 482957004765 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 482957004766 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 482957004767 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 482957004768 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 482957004769 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 482957004770 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 482957004771 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 482957004772 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 482957004773 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 482957004774 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 482957004775 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 482957004776 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 482957004777 Mg++ binding site [ion binding]; other site 482957004778 putative catalytic motif [active] 482957004779 putative substrate binding site [chemical binding]; other site 482957004780 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 482957004781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 482957004782 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 482957004783 cell division protein FtsW; Region: ftsW; TIGR02614 482957004784 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 482957004785 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 482957004786 active site 482957004787 homodimer interface [polypeptide binding]; other site 482957004788 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 482957004789 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 482957004790 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 482957004791 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 482957004792 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 482957004793 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 482957004794 ATP-grasp domain; Region: ATP-grasp_4; cl17255 482957004795 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 482957004796 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 482957004797 Cell division protein FtsQ; Region: FtsQ; pfam03799 482957004798 cell division protein FtsA; Region: ftsA; TIGR01174 482957004799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 482957004800 nucleotide binding site [chemical binding]; other site 482957004801 Cell division protein FtsA; Region: FtsA; pfam14450 482957004802 cell division protein FtsZ; Validated; Region: PRK09330 482957004803 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 482957004804 nucleotide binding site [chemical binding]; other site 482957004805 SulA interaction site; other site 482957004806 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 482957004807 catalytic triad [active] 482957004808 dimer interface [polypeptide binding]; other site 482957004809 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 482957004810 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 482957004811 Protein of unknown function (DUF721); Region: DUF721; pfam05258 482957004812 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 482957004813 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 482957004814 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 482957004815 SEC-C motif; Region: SEC-C; pfam02810 482957004816 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 482957004817 heterotetramer interface [polypeptide binding]; other site 482957004818 active site pocket [active] 482957004819 cleavage site 482957004820 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 482957004821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957004822 Walker A motif; other site 482957004823 ATP binding site [chemical binding]; other site 482957004824 Walker B motif; other site 482957004825 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 482957004826 active site 482957004827 8-oxo-dGMP binding site [chemical binding]; other site 482957004828 nudix motif; other site 482957004829 metal binding site [ion binding]; metal-binding site 482957004830 Domain of unknown function (DUF329); Region: DUF329; pfam03884 482957004831 hypothetical protein; Provisional; Region: PRK05287 482957004832 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 482957004833 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 482957004834 CoA-binding site [chemical binding]; other site 482957004835 ATP-binding [chemical binding]; other site 482957004836 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 482957004837 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 482957004838 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 482957004839 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957004840 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957004841 Type II/IV secretion system protein; Region: T2SE; pfam00437 482957004842 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 482957004843 Walker A motif; other site 482957004844 ATP binding site [chemical binding]; other site 482957004845 Walker B motif; other site 482957004846 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 482957004847 Domain of unknown function DUF21; Region: DUF21; pfam01595 482957004848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 482957004849 Transporter associated domain; Region: CorC_HlyC; smart01091 482957004850 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 482957004851 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 482957004852 substrate binding pocket [chemical binding]; other site 482957004853 chain length determination region; other site 482957004854 substrate-Mg2+ binding site; other site 482957004855 catalytic residues [active] 482957004856 aspartate-rich region 1; other site 482957004857 active site lid residues [active] 482957004858 aspartate-rich region 2; other site 482957004859 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 482957004860 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 482957004861 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 482957004862 GTPase CgtA; Reviewed; Region: obgE; PRK12299 482957004863 GTP1/OBG; Region: GTP1_OBG; pfam01018 482957004864 Obg GTPase; Region: Obg; cd01898 482957004865 G1 box; other site 482957004866 GTP/Mg2+ binding site [chemical binding]; other site 482957004867 Switch I region; other site 482957004868 G2 box; other site 482957004869 G3 box; other site 482957004870 Switch II region; other site 482957004871 G4 box; other site 482957004872 G5 box; other site 482957004873 gamma-glutamyl kinase; Provisional; Region: PRK05429 482957004874 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 482957004875 nucleotide binding site [chemical binding]; other site 482957004876 homotetrameric interface [polypeptide binding]; other site 482957004877 putative phosphate binding site [ion binding]; other site 482957004878 putative allosteric binding site; other site 482957004879 PUA domain; Region: PUA; pfam01472 482957004880 CNP1-like family; Region: CNP1; pfam08750 482957004881 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 482957004882 putative active site [active] 482957004883 Ap4A binding site [chemical binding]; other site 482957004884 nudix motif; other site 482957004885 putative metal binding site [ion binding]; other site 482957004886 prolyl-tRNA synthetase; Provisional; Region: PRK09194 482957004887 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 482957004888 dimer interface [polypeptide binding]; other site 482957004889 motif 1; other site 482957004890 active site 482957004891 motif 2; other site 482957004892 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 482957004893 putative deacylase active site [active] 482957004894 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 482957004895 active site 482957004896 motif 3; other site 482957004897 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 482957004898 anticodon binding site; other site 482957004899 MarC family integral membrane protein; Region: MarC; cl00919 482957004900 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957004901 active site 482957004902 signal recognition particle protein; Provisional; Region: PRK10867 482957004903 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 482957004904 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 482957004905 P loop; other site 482957004906 GTP binding site [chemical binding]; other site 482957004907 Signal peptide binding domain; Region: SRP_SPB; pfam02978 482957004908 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 482957004909 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 482957004910 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 482957004911 amidase catalytic site [active] 482957004912 Zn binding residues [ion binding]; other site 482957004913 substrate binding site [chemical binding]; other site 482957004914 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 482957004915 ATP cone domain; Region: ATP-cone; pfam03477 482957004916 Class I ribonucleotide reductase; Region: RNR_I; cd01679 482957004917 active site 482957004918 dimer interface [polypeptide binding]; other site 482957004919 catalytic residues [active] 482957004920 effector binding site; other site 482957004921 R2 peptide binding site; other site 482957004922 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 482957004923 dimer interface [polypeptide binding]; other site 482957004924 putative radical transfer pathway; other site 482957004925 diiron center [ion binding]; other site 482957004926 tyrosyl radical; other site 482957004927 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 482957004928 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957004929 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 482957004930 substrate binding site [chemical binding]; other site 482957004931 ATP binding site [chemical binding]; other site 482957004932 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 482957004933 dimer interface [polypeptide binding]; other site 482957004934 catalytic triad [active] 482957004935 peroxidatic and resolving cysteines [active] 482957004936 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 482957004937 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 482957004938 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 482957004939 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 482957004940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957004941 S-adenosylmethionine binding site [chemical binding]; other site 482957004942 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 482957004943 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 482957004944 ATP-grasp domain; Region: ATP-grasp_4; cl17255 482957004945 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 482957004946 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 482957004947 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 482957004948 carboxyltransferase (CT) interaction site; other site 482957004949 biotinylation site [posttranslational modification]; other site 482957004950 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 482957004951 Dehydroquinase class II; Region: DHquinase_II; pfam01220 482957004952 active site 482957004953 trimer interface [polypeptide binding]; other site 482957004954 dimer interface [polypeptide binding]; other site 482957004955 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 482957004956 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957004957 catalytic residues [active] 482957004958 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 482957004959 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 482957004960 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 482957004961 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 482957004962 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 482957004963 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957004964 Exoribonuclease R [Transcription]; Region: VacB; COG0557 482957004965 RNB domain; Region: RNB; pfam00773 482957004966 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 482957004967 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 482957004968 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 482957004969 shikimate binding site; other site 482957004970 NAD(P) binding site [chemical binding]; other site 482957004971 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 482957004972 Transglycosylase; Region: Transgly; cl17702 482957004973 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 482957004974 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 482957004975 EF-hand domain pair; Region: EF_hand_5; pfam13499 482957004976 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957004977 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957004978 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957004979 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 482957004980 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 482957004981 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 482957004982 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 482957004983 active site 482957004984 intersubunit interface [polypeptide binding]; other site 482957004985 catalytic residue [active] 482957004986 short chain dehydrogenase; Provisional; Region: PRK07063 482957004987 classical (c) SDRs; Region: SDR_c; cd05233 482957004988 NAD(P) binding site [chemical binding]; other site 482957004989 active site 482957004990 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 482957004991 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 482957004992 ligand binding site [chemical binding]; other site 482957004993 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 482957004994 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957004995 Walker A/P-loop; other site 482957004996 ATP binding site [chemical binding]; other site 482957004997 Q-loop/lid; other site 482957004998 ABC transporter signature motif; other site 482957004999 Walker B; other site 482957005000 D-loop; other site 482957005001 H-loop/switch region; other site 482957005002 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957005003 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957005004 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957005005 TM-ABC transporter signature motif; other site 482957005006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957005007 classical (c) SDRs; Region: SDR_c; cd05233 482957005008 NAD(P) binding site [chemical binding]; other site 482957005009 active site 482957005010 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 482957005011 active site 482957005012 catalytic residues [active] 482957005013 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 482957005014 active site 482957005015 dimer interface [polypeptide binding]; other site 482957005016 Competence-damaged protein; Region: CinA; pfam02464 482957005017 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 482957005018 tetramer interfaces [polypeptide binding]; other site 482957005019 binuclear metal-binding site [ion binding]; other site 482957005020 thiamine monophosphate kinase; Provisional; Region: PRK05731 482957005021 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 482957005022 ATP binding site [chemical binding]; other site 482957005023 dimerization interface [polypeptide binding]; other site 482957005024 malic enzyme; Reviewed; Region: PRK12862 482957005025 Malic enzyme, N-terminal domain; Region: malic; pfam00390 482957005026 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 482957005027 putative NAD(P) binding site [chemical binding]; other site 482957005028 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 482957005029 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 482957005030 active site 482957005031 barstar interaction site; other site 482957005032 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 482957005033 putative RNAase interaction site [polypeptide binding]; other site 482957005034 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 482957005035 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 482957005036 putative dimer interface [polypeptide binding]; other site 482957005037 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957005038 spermidine synthase; Provisional; Region: PRK00811 482957005039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957005040 transketolase; Reviewed; Region: PRK12753 482957005041 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 482957005042 TPP-binding site [chemical binding]; other site 482957005043 dimer interface [polypeptide binding]; other site 482957005044 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 482957005045 PYR/PP interface [polypeptide binding]; other site 482957005046 dimer interface [polypeptide binding]; other site 482957005047 TPP binding site [chemical binding]; other site 482957005048 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 482957005049 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 482957005050 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 482957005051 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 482957005052 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 482957005053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005054 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957005055 dimerization interface [polypeptide binding]; other site 482957005056 substrate binding pocket [chemical binding]; other site 482957005057 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 482957005058 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 482957005059 NADP binding site [chemical binding]; other site 482957005060 homodimer interface [polypeptide binding]; other site 482957005061 active site 482957005062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005063 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957005064 putative substrate translocation pore; other site 482957005065 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 482957005066 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 482957005067 putative ligand binding site [chemical binding]; other site 482957005068 NAD binding site [chemical binding]; other site 482957005069 catalytic site [active] 482957005070 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 482957005071 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 482957005072 putative NAD(P) binding site [chemical binding]; other site 482957005073 catalytic Zn binding site [ion binding]; other site 482957005074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005075 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957005076 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 482957005077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005078 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 482957005079 dimerization interface [polypeptide binding]; other site 482957005080 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957005081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957005082 DNA-binding site [nucleotide binding]; DNA binding site 482957005083 FCD domain; Region: FCD; pfam07729 482957005084 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 482957005085 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 482957005086 allantoicase; Provisional; Region: PRK13257 482957005087 Allantoicase repeat; Region: Allantoicase; pfam03561 482957005088 Allantoicase repeat; Region: Allantoicase; pfam03561 482957005089 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 482957005090 ureidoglycolate hydrolase; Provisional; Region: PRK13395 482957005091 ferric uptake regulator; Provisional; Region: fur; PRK09462 482957005092 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 482957005093 metal binding site 2 [ion binding]; metal-binding site 482957005094 putative DNA binding helix; other site 482957005095 metal binding site 1 [ion binding]; metal-binding site 482957005096 dimer interface [polypeptide binding]; other site 482957005097 structural Zn2+ binding site [ion binding]; other site 482957005098 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 482957005099 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 482957005100 dihydrodipicolinate reductase; Provisional; Region: PRK00048 482957005101 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 482957005102 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 482957005103 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 482957005104 TolR protein; Region: tolR; TIGR02801 482957005105 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957005106 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 482957005107 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 482957005108 HIGH motif; other site 482957005109 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 482957005110 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957005111 active site 482957005112 KMSKS motif; other site 482957005113 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 482957005114 tRNA binding surface [nucleotide binding]; other site 482957005115 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 482957005116 Lipopolysaccharide-assembly; Region: LptE; cl01125 482957005117 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 482957005118 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 482957005119 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 482957005120 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 482957005121 putative catalytic cysteine [active] 482957005122 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 482957005123 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 482957005124 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957005125 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 482957005126 putative active site [active] 482957005127 phosphogluconate dehydratase; Validated; Region: PRK09054 482957005128 6-phosphogluconate dehydratase; Region: edd; TIGR01196 482957005129 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 482957005130 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 482957005131 active site 482957005132 intersubunit interface [polypeptide binding]; other site 482957005133 catalytic residue [active] 482957005134 fructuronate transporter; Provisional; Region: PRK10034; cl15264 482957005135 GntP family permease; Region: GntP_permease; pfam02447 482957005136 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 482957005137 ATP-binding site [chemical binding]; other site 482957005138 Gluconate-6-phosphate binding site [chemical binding]; other site 482957005139 Shikimate kinase; Region: SKI; pfam01202 482957005140 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 482957005141 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957005142 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957005143 adenylosuccinate lyase; Provisional; Region: PRK09285 482957005144 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 482957005145 tetramer interface [polypeptide binding]; other site 482957005146 active site 482957005147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957005148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957005150 dimerization interface [polypeptide binding]; other site 482957005151 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 482957005152 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 482957005153 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 482957005154 NAD(P) binding site [chemical binding]; other site 482957005155 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 482957005156 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957005157 substrate binding pocket [chemical binding]; other site 482957005158 membrane-bound complex binding site; other site 482957005159 hinge residues; other site 482957005160 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957005161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957005162 dimer interface [polypeptide binding]; other site 482957005163 conserved gate region; other site 482957005164 putative PBP binding loops; other site 482957005165 ABC-ATPase subunit interface; other site 482957005166 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957005167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957005168 dimer interface [polypeptide binding]; other site 482957005169 conserved gate region; other site 482957005170 putative PBP binding loops; other site 482957005171 ABC-ATPase subunit interface; other site 482957005172 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 482957005173 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957005174 Walker A/P-loop; other site 482957005175 ATP binding site [chemical binding]; other site 482957005176 Q-loop/lid; other site 482957005177 ABC transporter signature motif; other site 482957005178 Walker B; other site 482957005179 D-loop; other site 482957005180 H-loop/switch region; other site 482957005181 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 482957005182 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 482957005183 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 482957005184 Autotransporter beta-domain; Region: Autotransporter; smart00869 482957005185 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 482957005186 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 482957005187 putative active site [active] 482957005188 putative dimer interface [polypeptide binding]; other site 482957005189 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 482957005190 active site 482957005191 substrate binding pocket [chemical binding]; other site 482957005192 dimer interface [polypeptide binding]; other site 482957005193 OsmC-like protein; Region: OsmC; cl00767 482957005194 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 482957005195 23S rRNA interface [nucleotide binding]; other site 482957005196 L3 interface [polypeptide binding]; other site 482957005197 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 482957005198 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 482957005199 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 482957005200 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 482957005201 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 482957005202 active site 482957005203 HIGH motif; other site 482957005204 dimer interface [polypeptide binding]; other site 482957005205 KMSKS motif; other site 482957005206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957005207 RNA binding surface [nucleotide binding]; other site 482957005208 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 482957005209 putative active site [active] 482957005210 dimerization interface [polypeptide binding]; other site 482957005211 putative tRNAtyr binding site [nucleotide binding]; other site 482957005212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 482957005213 catalytic core [active] 482957005214 Putative ParB-like nuclease; Region: ParBc_2; cl17538 482957005215 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 482957005216 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 482957005217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957005218 Walker A motif; other site 482957005219 ATP binding site [chemical binding]; other site 482957005220 Walker B motif; other site 482957005221 arginine finger; other site 482957005222 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 482957005223 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 482957005224 RuvA N terminal domain; Region: RuvA_N; pfam01330 482957005225 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 482957005226 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 482957005227 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 482957005228 active site 482957005229 putative DNA-binding cleft [nucleotide binding]; other site 482957005230 dimer interface [polypeptide binding]; other site 482957005231 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 482957005232 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 482957005233 purine monophosphate binding site [chemical binding]; other site 482957005234 dimer interface [polypeptide binding]; other site 482957005235 putative catalytic residues [active] 482957005236 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 482957005237 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 482957005238 DNA-binding protein Fis; Provisional; Region: PRK01905 482957005239 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 482957005240 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 482957005241 FMN binding site [chemical binding]; other site 482957005242 active site 482957005243 catalytic residues [active] 482957005244 substrate binding site [chemical binding]; other site 482957005245 hypothetical protein; Provisional; Region: PRK06996 482957005246 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957005247 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 482957005248 proline aminopeptidase P II; Provisional; Region: PRK10879 482957005249 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 482957005250 active site 482957005251 putative glutathione S-transferase; Provisional; Region: PRK10357 482957005252 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 482957005253 putative C-terminal domain interface [polypeptide binding]; other site 482957005254 putative GSH binding site (G-site) [chemical binding]; other site 482957005255 putative dimer interface [polypeptide binding]; other site 482957005256 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 482957005257 dimer interface [polypeptide binding]; other site 482957005258 N-terminal domain interface [polypeptide binding]; other site 482957005259 putative substrate binding pocket (H-site) [chemical binding]; other site 482957005260 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 482957005261 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 482957005262 active site 482957005263 FMN binding site [chemical binding]; other site 482957005264 substrate binding site [chemical binding]; other site 482957005265 3Fe-4S cluster binding site [ion binding]; other site 482957005266 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 482957005267 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 482957005268 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 482957005269 nudix motif; other site 482957005270 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 482957005271 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 482957005272 ligand binding site [chemical binding]; other site 482957005273 homodimer interface [polypeptide binding]; other site 482957005274 NAD(P) binding site [chemical binding]; other site 482957005275 trimer interface B [polypeptide binding]; other site 482957005276 trimer interface A [polypeptide binding]; other site 482957005277 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 482957005278 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 482957005279 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 482957005280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957005281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005282 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 482957005283 putative substrate binding pocket [chemical binding]; other site 482957005284 putative dimerization interface [polypeptide binding]; other site 482957005285 Predicted amidohydrolase [General function prediction only]; Region: COG0388 482957005286 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 482957005287 putative active site [active] 482957005288 catalytic triad [active] 482957005289 putative dimer interface [polypeptide binding]; other site 482957005290 Predicted transcriptional regulator [Transcription]; Region: COG2378 482957005291 HTH domain; Region: HTH_11; pfam08279 482957005292 WYL domain; Region: WYL; pfam13280 482957005293 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 482957005294 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957005295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957005296 dimerization interface [polypeptide binding]; other site 482957005297 putative DNA binding site [nucleotide binding]; other site 482957005298 putative Zn2+ binding site [ion binding]; other site 482957005299 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 482957005300 putative hydrophobic ligand binding site [chemical binding]; other site 482957005301 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 482957005302 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 482957005303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 482957005304 Site-specific recombinase; Region: SpecificRecomb; pfam10136 482957005305 Protein of unknown function (DUF330); Region: DUF330; pfam03886 482957005306 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 482957005307 mce related protein; Region: MCE; pfam02470 482957005308 mce related protein; Region: MCE; pfam02470 482957005309 Paraquat-inducible protein A; Region: PqiA; pfam04403 482957005310 Paraquat-inducible protein A; Region: PqiA; pfam04403 482957005311 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 482957005312 YceI-like domain; Region: YceI; smart00867 482957005313 Uncharacterized conserved protein [Function unknown]; Region: COG2353 482957005314 citrate-proton symporter; Provisional; Region: PRK15075 482957005315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005316 putative substrate translocation pore; other site 482957005317 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 482957005318 protein binding site [polypeptide binding]; other site 482957005319 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 482957005320 Catalytic dyad [active] 482957005321 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 482957005322 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 482957005323 Protein export membrane protein; Region: SecD_SecF; pfam02355 482957005324 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 482957005325 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 482957005326 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 482957005327 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 482957005328 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 482957005329 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 482957005330 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 482957005331 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 482957005332 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 482957005333 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 482957005334 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 482957005335 ssDNA binding site; other site 482957005336 generic binding surface II; other site 482957005337 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957005338 ATP binding site [chemical binding]; other site 482957005339 putative Mg++ binding site [ion binding]; other site 482957005340 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957005341 nucleotide binding region [chemical binding]; other site 482957005342 ATP-binding site [chemical binding]; other site 482957005343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957005344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005345 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 482957005346 dimerization interface [polypeptide binding]; other site 482957005347 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 482957005348 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 482957005349 dimer interface [polypeptide binding]; other site 482957005350 active site 482957005351 heme binding site [chemical binding]; other site 482957005352 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 482957005353 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 482957005354 UbiA prenyltransferase family; Region: UbiA; pfam01040 482957005355 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 482957005356 pyrroline-5-carboxylate reductase; Region: PLN02688 482957005357 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 482957005358 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957005359 catalytic residue [active] 482957005360 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 482957005361 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 482957005362 Cysteine-rich domain; Region: CCG; pfam02754 482957005363 Cysteine-rich domain; Region: CCG; pfam02754 482957005364 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 482957005365 FAD binding domain; Region: FAD_binding_4; pfam01565 482957005366 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 482957005367 FAD binding domain; Region: FAD_binding_4; pfam01565 482957005368 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957005369 FAD binding domain; Region: FAD_binding_4; pfam01565 482957005370 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 482957005371 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 482957005372 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 482957005373 heme-binding site [chemical binding]; other site 482957005374 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 482957005375 FAD binding pocket [chemical binding]; other site 482957005376 FAD binding motif [chemical binding]; other site 482957005377 phosphate binding motif [ion binding]; other site 482957005378 beta-alpha-beta structure motif; other site 482957005379 NAD binding pocket [chemical binding]; other site 482957005380 Heme binding pocket [chemical binding]; other site 482957005381 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 482957005382 putative active site [active] 482957005383 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 482957005384 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 482957005385 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 482957005386 protease TldD; Provisional; Region: tldD; PRK10735 482957005387 nitrilase; Region: PLN02798 482957005388 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 482957005389 putative active site [active] 482957005390 catalytic triad [active] 482957005391 dimer interface [polypeptide binding]; other site 482957005392 TIGR02099 family protein; Region: TIGR02099 482957005393 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 482957005394 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 482957005395 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 482957005396 metal binding triad; other site 482957005397 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 482957005398 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 482957005399 metal binding triad; other site 482957005400 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 482957005401 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 482957005402 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 482957005403 Walker A/P-loop; other site 482957005404 ATP binding site [chemical binding]; other site 482957005405 Q-loop/lid; other site 482957005406 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 482957005407 ABC transporter signature motif; other site 482957005408 Walker B; other site 482957005409 D-loop; other site 482957005410 H-loop/switch region; other site 482957005411 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 482957005412 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 482957005413 possible frameshift; similar to transcriptional regulator of heat shock gene-like 482957005414 ferrochelatase; Reviewed; Region: hemH; PRK00035 482957005415 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 482957005416 C-terminal domain interface [polypeptide binding]; other site 482957005417 active site 482957005418 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 482957005419 active site 482957005420 N-terminal domain interface [polypeptide binding]; other site 482957005421 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957005422 RNA binding surface [nucleotide binding]; other site 482957005423 GrpE; Region: GrpE; pfam01025 482957005424 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 482957005425 dimer interface [polypeptide binding]; other site 482957005426 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 482957005427 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 482957005428 catalytic residues [active] 482957005429 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 482957005430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 482957005431 nucleotide binding site [chemical binding]; other site 482957005432 chaperone protein DnaJ; Provisional; Region: PRK10767 482957005433 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 482957005434 HSP70 interaction site [polypeptide binding]; other site 482957005435 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 482957005436 Zn binding sites [ion binding]; other site 482957005437 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 482957005438 dimer interface [polypeptide binding]; other site 482957005439 chorismate binding enzyme; Region: Chorismate_bind; cl10555 482957005440 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 482957005441 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 482957005442 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 482957005443 homodimer interface [polypeptide binding]; other site 482957005444 substrate-cofactor binding pocket; other site 482957005445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957005446 catalytic residue [active] 482957005447 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 482957005448 oligomerization interface [polypeptide binding]; other site 482957005449 active site 482957005450 metal binding site [ion binding]; metal-binding site 482957005451 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 482957005452 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 482957005453 Substrate-binding site [chemical binding]; other site 482957005454 Substrate specificity [chemical binding]; other site 482957005455 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 482957005456 catalytic center binding site [active] 482957005457 ATP binding site [chemical binding]; other site 482957005458 poly(A) polymerase; Region: pcnB; TIGR01942 482957005459 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 482957005460 active site 482957005461 NTP binding site [chemical binding]; other site 482957005462 metal binding triad [ion binding]; metal-binding site 482957005463 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 482957005464 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 482957005465 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 482957005466 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 482957005467 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 482957005468 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 482957005469 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 482957005470 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 482957005471 dimerization interface [polypeptide binding]; other site 482957005472 putative ATP binding site [chemical binding]; other site 482957005473 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 482957005474 SnoaL-like domain; Region: SnoaL_3; pfam13474 482957005475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957005477 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 482957005478 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 482957005479 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 482957005480 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 482957005481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957005482 ATP binding site [chemical binding]; other site 482957005483 Mg2+ binding site [ion binding]; other site 482957005484 G-X-G motif; other site 482957005485 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 482957005486 ATP binding site [chemical binding]; other site 482957005487 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 482957005488 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 482957005489 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 482957005490 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 482957005491 Mechanosensitive ion channel; Region: MS_channel; pfam00924 482957005492 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 482957005493 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 482957005494 Substrate binding site; other site 482957005495 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 482957005496 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 482957005497 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 482957005498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957005499 polysaccharide export protein Wza; Provisional; Region: PRK15078 482957005500 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 482957005501 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 482957005502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957005503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957005504 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957005505 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957005506 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957005507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957005508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957005509 FkbH-like domain; Region: FkbH; TIGR01686 482957005510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957005511 active site 482957005512 motif I; other site 482957005513 motif II; other site 482957005514 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 482957005515 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 482957005516 Walker A/P-loop; other site 482957005517 ATP binding site [chemical binding]; other site 482957005518 Q-loop/lid; other site 482957005519 ABC transporter signature motif; other site 482957005520 Walker B; other site 482957005521 D-loop; other site 482957005522 H-loop/switch region; other site 482957005523 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 482957005524 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 482957005525 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 482957005526 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 482957005527 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 482957005528 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 482957005529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957005530 NAD(P) binding site [chemical binding]; other site 482957005531 active site 482957005532 Sulfatase; Region: Sulfatase; pfam00884 482957005533 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 482957005534 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 482957005535 active site 482957005536 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 482957005537 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 482957005538 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957005539 Methyltransferase domain; Region: Methyltransf_12; pfam08242 482957005540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957005541 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 482957005542 Enoylreductase; Region: PKS_ER; smart00829 482957005543 NAD(P) binding site [chemical binding]; other site 482957005544 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 482957005545 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 482957005546 putative NADP binding site [chemical binding]; other site 482957005547 active site 482957005548 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 482957005549 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 482957005550 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 482957005551 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 482957005552 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 482957005553 substrate-cofactor binding pocket; other site 482957005554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957005555 catalytic residue [active] 482957005556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957005557 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 482957005558 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 482957005559 putative active site [active] 482957005560 putative dimer interface [polypeptide binding]; other site 482957005561 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957005562 Cupin; Region: Cupin_6; pfam12852 482957005563 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957005564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957005565 yiaA/B two helix domain; Region: YiaAB; pfam05360 482957005566 yiaA/B two helix domain; Region: YiaAB; pfam05360 482957005567 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 482957005568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 482957005569 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 482957005570 dinuclear metal binding motif [ion binding]; other site 482957005571 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 482957005572 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 482957005573 active site 482957005574 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 482957005575 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957005576 putative di-iron ligands [ion binding]; other site 482957005577 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 482957005578 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 482957005579 Tetratricopeptide repeat; Region: TPR_6; pfam13174 482957005580 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 482957005581 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957005582 ligand binding site [chemical binding]; other site 482957005583 translocation protein TolB; Provisional; Region: tolB; PRK02889 482957005584 TolB amino-terminal domain; Region: TolB_N; pfam04052 482957005585 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 482957005586 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 482957005587 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 482957005588 TolA protein; Region: tolA_full; TIGR02794 482957005589 TonB C terminal; Region: TonB_2; pfam13103 482957005590 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957005591 TolR protein; Region: tolR; TIGR02801 482957005592 TolQ protein; Region: tolQ; TIGR02796 482957005593 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 482957005594 active site 482957005595 malonic semialdehyde reductase; Provisional; Region: PRK10538 482957005596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957005597 NAD(P) binding site [chemical binding]; other site 482957005598 active site 482957005599 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 482957005600 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 482957005601 dimer interface [polypeptide binding]; other site 482957005602 active site 482957005603 glycine-pyridoxal phosphate binding site [chemical binding]; other site 482957005604 folate binding site [chemical binding]; other site 482957005605 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 482957005606 ATP cone domain; Region: ATP-cone; pfam03477 482957005607 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 482957005608 Type II transport protein GspH; Region: GspH; pfam12019 482957005609 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 482957005610 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 482957005611 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 482957005612 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 482957005613 Predicted membrane protein [Function unknown]; Region: COG5393 482957005614 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 482957005615 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 482957005616 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 482957005617 dimer interface [polypeptide binding]; other site 482957005618 decamer (pentamer of dimers) interface [polypeptide binding]; other site 482957005619 catalytic triad [active] 482957005620 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 482957005621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957005622 FAD binding site [chemical binding]; other site 482957005623 substrate binding pocket [chemical binding]; other site 482957005624 catalytic base [active] 482957005625 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957005626 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957005627 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957005628 Uncharacterized conserved protein [Function unknown]; Region: COG3791 482957005629 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 482957005630 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 482957005631 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957005632 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957005633 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 482957005634 benzoate transport; Region: 2A0115; TIGR00895 482957005635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005636 putative substrate translocation pore; other site 482957005637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005638 putative substrate translocation pore; other site 482957005639 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 482957005640 fumarylacetoacetase; Region: PLN02856 482957005641 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 482957005642 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957005643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957005645 putative substrate translocation pore; other site 482957005646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005647 putative substrate translocation pore; other site 482957005648 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957005649 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 482957005650 putative FMN binding site [chemical binding]; other site 482957005651 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 482957005652 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 482957005653 putative ligand binding site [chemical binding]; other site 482957005654 putative NAD binding site [chemical binding]; other site 482957005655 catalytic site [active] 482957005656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957005658 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957005659 putative effector binding pocket; other site 482957005660 dimerization interface [polypeptide binding]; other site 482957005661 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 482957005662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957005663 catalytic residue [active] 482957005664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957005665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957005666 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 482957005667 major facilitator superfamily transporter; Provisional; Region: PRK05122 482957005668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005669 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 482957005670 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957005671 catalytic loop [active] 482957005672 iron binding site [ion binding]; other site 482957005673 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957005674 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 482957005675 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 482957005676 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 482957005677 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957005678 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 482957005679 XdhC Rossmann domain; Region: XdhC_C; pfam13478 482957005680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 482957005681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957005682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957005684 dimerization interface [polypeptide binding]; other site 482957005685 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 482957005686 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 482957005687 putative catalytic residue [active] 482957005688 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 482957005689 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 482957005690 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 482957005691 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 482957005692 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 482957005693 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005695 putative substrate translocation pore; other site 482957005696 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 482957005697 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 482957005698 catalytic residues [active] 482957005699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 482957005700 YheO-like PAS domain; Region: PAS_6; pfam08348 482957005701 HTH domain; Region: HTH_22; pfam13309 482957005702 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 482957005703 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 482957005704 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 482957005705 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957005706 substrate binding pocket [chemical binding]; other site 482957005707 membrane-bound complex binding site; other site 482957005708 hinge residues; other site 482957005709 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957005710 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957005711 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957005712 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 482957005713 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 482957005714 RNA polymerase sigma factor; Provisional; Region: PRK12511 482957005715 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957005716 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957005717 DNA binding residues [nucleotide binding] 482957005718 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 482957005719 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 482957005720 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 482957005721 putative hydrophobic ligand binding site [chemical binding]; other site 482957005722 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 482957005723 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 482957005724 Walker A/P-loop; other site 482957005725 ATP binding site [chemical binding]; other site 482957005726 Q-loop/lid; other site 482957005727 ABC transporter signature motif; other site 482957005728 Walker B; other site 482957005729 D-loop; other site 482957005730 H-loop/switch region; other site 482957005731 TOBE domain; Region: TOBE_2; pfam08402 482957005732 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 482957005733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957005734 ABC-ATPase subunit interface; other site 482957005735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957005736 dimer interface [polypeptide binding]; other site 482957005737 conserved gate region; other site 482957005738 putative PBP binding loops; other site 482957005739 ABC-ATPase subunit interface; other site 482957005740 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957005741 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 482957005742 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 482957005743 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 482957005744 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 482957005745 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 482957005746 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 482957005747 oligomerisation interface [polypeptide binding]; other site 482957005748 mobile loop; other site 482957005749 roof hairpin; other site 482957005750 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 482957005751 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 482957005752 ring oligomerisation interface [polypeptide binding]; other site 482957005753 ATP/Mg binding site [chemical binding]; other site 482957005754 stacking interactions; other site 482957005755 hinge regions; other site 482957005756 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 482957005757 amidase catalytic site [active] 482957005758 Zn binding residues [ion binding]; other site 482957005759 substrate binding site [chemical binding]; other site 482957005760 Protein of unknown function (DUF796); Region: DUF796; pfam05638 482957005761 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 482957005762 dimer interface [polypeptide binding]; other site 482957005763 substrate binding site [chemical binding]; other site 482957005764 ATP binding site [chemical binding]; other site 482957005765 Rubredoxin [Energy production and conversion]; Region: COG1773 482957005766 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 482957005767 iron binding site [ion binding]; other site 482957005768 hypothetical protein; Validated; Region: PRK00228 482957005769 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 482957005770 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957005771 active site 482957005772 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 482957005773 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 482957005774 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 482957005775 dihydroorotase; Provisional; Region: PRK07627 482957005776 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957005777 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 482957005778 active site 482957005779 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 482957005780 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 482957005781 putative acyl-acceptor binding pocket; other site 482957005782 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 482957005783 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 482957005784 active site 482957005785 metal binding site [ion binding]; metal-binding site 482957005786 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 482957005787 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 482957005788 NAD binding site [chemical binding]; other site 482957005789 substrate binding site [chemical binding]; other site 482957005790 homodimer interface [polypeptide binding]; other site 482957005791 active site 482957005792 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 482957005793 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 482957005794 substrate binding site; other site 482957005795 tetramer interface; other site 482957005796 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 482957005797 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 482957005798 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 482957005799 NADP binding site [chemical binding]; other site 482957005800 active site 482957005801 putative substrate binding site [chemical binding]; other site 482957005802 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 482957005803 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957005804 putative homodimer interface [polypeptide binding]; other site 482957005805 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 482957005806 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 482957005807 active site 482957005808 homodimer interface [polypeptide binding]; other site 482957005809 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 482957005810 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957005811 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 482957005812 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 482957005813 Probable Catalytic site; other site 482957005814 metal-binding site 482957005815 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 482957005816 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 482957005817 Walker A/P-loop; other site 482957005818 ATP binding site [chemical binding]; other site 482957005819 Q-loop/lid; other site 482957005820 ABC transporter signature motif; other site 482957005821 Walker B; other site 482957005822 D-loop; other site 482957005823 H-loop/switch region; other site 482957005824 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 482957005825 putative carbohydrate binding site [chemical binding]; other site 482957005826 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 482957005827 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 482957005828 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 482957005829 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 482957005830 trimer interface [polypeptide binding]; other site 482957005831 active site 482957005832 substrate binding site [chemical binding]; other site 482957005833 CoA binding site [chemical binding]; other site 482957005834 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 482957005835 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 482957005836 Substrate binding site; other site 482957005837 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 482957005838 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 482957005839 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 482957005840 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 482957005841 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 482957005842 Probable Catalytic site; other site 482957005843 metal-binding site 482957005844 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957005845 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 482957005846 putative NAD(P) binding site [chemical binding]; other site 482957005847 active site 482957005848 putative substrate binding site [chemical binding]; other site 482957005849 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 482957005850 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 482957005851 Mg++ binding site [ion binding]; other site 482957005852 putative catalytic motif [active] 482957005853 putative substrate binding site [chemical binding]; other site 482957005854 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 482957005855 CoA binding domain; Region: CoA_binding; cl17356 482957005856 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 482957005857 NAD(P) binding site [chemical binding]; other site 482957005858 homodimer interface [polypeptide binding]; other site 482957005859 substrate binding site [chemical binding]; other site 482957005860 active site 482957005861 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 482957005862 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 482957005863 Mg++ binding site [ion binding]; other site 482957005864 putative catalytic motif [active] 482957005865 UDP-glucose 4-epimerase; Region: PLN02240 482957005866 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 482957005867 NAD binding site [chemical binding]; other site 482957005868 homodimer interface [polypeptide binding]; other site 482957005869 active site 482957005870 substrate binding site [chemical binding]; other site 482957005871 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 482957005872 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957005873 putative ADP-binding pocket [chemical binding]; other site 482957005874 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 482957005875 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 482957005876 active site 482957005877 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 482957005878 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 482957005879 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 482957005880 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 482957005881 active site 482957005882 substrate binding site [chemical binding]; other site 482957005883 metal binding site [ion binding]; metal-binding site 482957005884 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 482957005885 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957005886 Methyltransferase domain; Region: Methyltransf_11; pfam08241 482957005887 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 482957005888 Transposase, Mutator family; Region: Transposase_mut; pfam00872 482957005889 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 482957005890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957005891 Integrase core domain; Region: rve; pfam00665 482957005892 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 482957005893 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 482957005894 putative active site [active] 482957005895 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 482957005896 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 482957005897 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 482957005898 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957005899 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 482957005900 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 482957005901 UreF; Region: UreF; pfam01730 482957005902 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 482957005903 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 482957005904 dimer interface [polypeptide binding]; other site 482957005905 catalytic residues [active] 482957005906 urease subunit alpha; Reviewed; Region: ureC; PRK13207 482957005907 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 482957005908 subunit interactions [polypeptide binding]; other site 482957005909 active site 482957005910 flap region; other site 482957005911 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 482957005912 gamma-beta subunit interface [polypeptide binding]; other site 482957005913 alpha-beta subunit interface [polypeptide binding]; other site 482957005914 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 482957005915 alpha-gamma subunit interface [polypeptide binding]; other site 482957005916 beta-gamma subunit interface [polypeptide binding]; other site 482957005917 UreD urease accessory protein; Region: UreD; cl00530 482957005918 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 482957005919 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957005920 Walker A/P-loop; other site 482957005921 ATP binding site [chemical binding]; other site 482957005922 Q-loop/lid; other site 482957005923 ABC transporter signature motif; other site 482957005924 Walker B; other site 482957005925 D-loop; other site 482957005926 H-loop/switch region; other site 482957005927 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 482957005928 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957005929 Walker A/P-loop; other site 482957005930 ATP binding site [chemical binding]; other site 482957005931 Q-loop/lid; other site 482957005932 ABC transporter signature motif; other site 482957005933 Walker B; other site 482957005934 D-loop; other site 482957005935 H-loop/switch region; other site 482957005936 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 482957005937 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957005938 TM-ABC transporter signature motif; other site 482957005939 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957005940 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957005941 TM-ABC transporter signature motif; other site 482957005942 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 482957005943 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 482957005944 putative ligand binding site [chemical binding]; other site 482957005945 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 482957005946 active site residue [active] 482957005947 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 482957005948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957005949 S-adenosylmethionine binding site [chemical binding]; other site 482957005950 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 482957005951 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957005952 FeS/SAM binding site; other site 482957005953 HemN C-terminal domain; Region: HemN_C; pfam06969 482957005954 Flagellin N-methylase; Region: FliB; pfam03692 482957005955 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 482957005956 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 482957005957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957005958 S-adenosylmethionine binding site [chemical binding]; other site 482957005959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 482957005960 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957005961 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957005962 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957005963 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957005964 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 482957005965 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 482957005966 CGNR zinc finger; Region: zf-CGNR; pfam11706 482957005967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957005968 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957005969 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957005970 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 482957005971 putative NAD(P) binding site [chemical binding]; other site 482957005972 putative active site [active] 482957005973 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 482957005974 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 482957005975 putative active site pocket [active] 482957005976 metal binding site [ion binding]; metal-binding site 482957005977 LysE type translocator; Region: LysE; cl00565 482957005978 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 482957005979 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 482957005980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957005981 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 482957005982 putative dimerization interface [polypeptide binding]; other site 482957005983 benzoate transport; Region: 2A0115; TIGR00895 482957005984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957005985 putative substrate translocation pore; other site 482957005986 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957005987 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957005988 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 482957005989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957005990 substrate binding site [chemical binding]; other site 482957005991 oxyanion hole (OAH) forming residues; other site 482957005992 trimer interface [polypeptide binding]; other site 482957005993 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 482957005994 Chromate transporter; Region: Chromate_transp; pfam02417 482957005995 Chromate transporter; Region: Chromate_transp; pfam02417 482957005996 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 482957005997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957005998 DNA-binding site [nucleotide binding]; DNA binding site 482957005999 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 482957006000 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 482957006001 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 482957006002 dimer interface [polypeptide binding]; other site 482957006003 ADP-ribose binding site [chemical binding]; other site 482957006004 active site 482957006005 nudix motif; other site 482957006006 metal binding site [ion binding]; metal-binding site 482957006007 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 482957006008 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 482957006009 Transposase; Region: DEDD_Tnp_IS110; pfam01548 482957006010 chromosome condensation membrane protein; Provisional; Region: PRK14196 482957006011 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 482957006012 YGGT family; Region: YGGT; pfam02325 482957006013 YGGT family; Region: YGGT; pfam02325 482957006014 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 482957006015 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 482957006016 LysE type translocator; Region: LysE; pfam01810 482957006017 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 482957006018 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957006019 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957006020 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957006021 catalytic residue [active] 482957006022 aminotransferase; Validated; Region: PRK07337 482957006023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957006024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957006025 homodimer interface [polypeptide binding]; other site 482957006026 catalytic residue [active] 482957006027 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 482957006028 putative RNA binding site [nucleotide binding]; other site 482957006029 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 482957006030 homopentamer interface [polypeptide binding]; other site 482957006031 active site 482957006032 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 482957006033 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 482957006034 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 482957006035 dimerization interface [polypeptide binding]; other site 482957006036 active site 482957006037 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 482957006038 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 482957006039 Part of AAA domain; Region: AAA_19; pfam13245 482957006040 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 482957006041 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 482957006042 Lumazine binding domain; Region: Lum_binding; pfam00677 482957006043 Lumazine binding domain; Region: Lum_binding; pfam00677 482957006044 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 482957006045 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 482957006046 catalytic motif [active] 482957006047 Zn binding site [ion binding]; other site 482957006048 RibD C-terminal domain; Region: RibD_C; cl17279 482957006049 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 482957006050 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957006051 inhibitor-cofactor binding pocket; inhibition site 482957006052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957006053 catalytic residue [active] 482957006054 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 482957006055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957006056 putative substrate translocation pore; other site 482957006057 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 482957006058 glucokinase; Provisional; Region: glk; PRK00292 482957006059 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957006060 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 482957006061 putative active site [active] 482957006062 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 482957006063 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 482957006064 putative active site [active] 482957006065 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 482957006066 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 482957006067 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 482957006068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 482957006069 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 482957006070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006071 dimer interface [polypeptide binding]; other site 482957006072 conserved gate region; other site 482957006073 putative PBP binding loops; other site 482957006074 ABC-ATPase subunit interface; other site 482957006075 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 482957006076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006077 dimer interface [polypeptide binding]; other site 482957006078 conserved gate region; other site 482957006079 putative PBP binding loops; other site 482957006080 ABC-ATPase subunit interface; other site 482957006081 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 482957006082 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 482957006083 Walker A/P-loop; other site 482957006084 ATP binding site [chemical binding]; other site 482957006085 Q-loop/lid; other site 482957006086 ABC transporter signature motif; other site 482957006087 Walker B; other site 482957006088 D-loop; other site 482957006089 H-loop/switch region; other site 482957006090 TOBE domain; Region: TOBE_2; pfam08402 482957006091 Predicted membrane protein [Function unknown]; Region: COG2860 482957006092 UPF0126 domain; Region: UPF0126; pfam03458 482957006093 UPF0126 domain; Region: UPF0126; pfam03458 482957006094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 482957006095 Smr domain; Region: Smr; pfam01713 482957006096 thioredoxin reductase; Provisional; Region: PRK10262 482957006097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957006098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957006099 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 482957006100 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 482957006101 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 482957006102 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 482957006103 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 482957006104 recombination factor protein RarA; Reviewed; Region: PRK13342 482957006105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957006106 Walker A motif; other site 482957006107 ATP binding site [chemical binding]; other site 482957006108 Walker B motif; other site 482957006109 arginine finger; other site 482957006110 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 482957006111 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 482957006112 seryl-tRNA synthetase; Provisional; Region: PRK05431 482957006113 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 482957006114 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 482957006115 dimer interface [polypeptide binding]; other site 482957006116 active site 482957006117 motif 1; other site 482957006118 motif 2; other site 482957006119 motif 3; other site 482957006120 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 482957006121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957006122 dimerization interface [polypeptide binding]; other site 482957006123 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957006124 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957006125 dimer interface [polypeptide binding]; other site 482957006126 putative CheW interface [polypeptide binding]; other site 482957006127 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 482957006128 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957006129 Di-iron ligands [ion binding]; other site 482957006130 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957006131 septum formation inhibitor; Reviewed; Region: PRK01973 482957006132 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 482957006133 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 482957006134 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 482957006135 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 482957006136 Switch I; other site 482957006137 Switch II; other site 482957006138 cell division topological specificity factor MinE; Provisional; Region: PRK13989 482957006139 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 482957006140 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 482957006141 putative ion selectivity filter; other site 482957006142 putative pore gating glutamate residue; other site 482957006143 putative H+/Cl- coupling transport residue; other site 482957006144 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 482957006145 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 482957006146 putative active site [active] 482957006147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957006148 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957006149 putative substrate translocation pore; other site 482957006150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 482957006151 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957006152 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957006153 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957006154 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957006155 PAAR motif; Region: PAAR_motif; pfam05488 482957006156 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 482957006157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957006158 FeS/SAM binding site; other site 482957006159 HemN C-terminal domain; Region: HemN_C; pfam06969 482957006160 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 482957006161 active site 482957006162 dimerization interface [polypeptide binding]; other site 482957006163 ribonuclease PH; Reviewed; Region: rph; PRK00173 482957006164 Ribonuclease PH; Region: RNase_PH_bact; cd11362 482957006165 hexamer interface [polypeptide binding]; other site 482957006166 active site 482957006167 hypothetical protein; Provisional; Region: PRK11820 482957006168 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 482957006169 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 482957006170 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 482957006171 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 482957006172 catalytic site [active] 482957006173 G-X2-G-X-G-K; other site 482957006174 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 482957006175 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 482957006176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 482957006177 Zn2+ binding site [ion binding]; other site 482957006178 Mg2+ binding site [ion binding]; other site 482957006179 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 482957006180 synthetase active site [active] 482957006181 NTP binding site [chemical binding]; other site 482957006182 metal binding site [ion binding]; metal-binding site 482957006183 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 482957006184 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 482957006185 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 482957006186 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 482957006187 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 482957006188 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957006189 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957006190 trimer interface [polypeptide binding]; other site 482957006191 eyelet of channel; other site 482957006192 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 482957006193 DNA-binding site [nucleotide binding]; DNA binding site 482957006194 RNA-binding motif; other site 482957006195 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 482957006196 active site 482957006197 catalytic site [active] 482957006198 substrate binding site [chemical binding]; other site 482957006199 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 482957006200 GIY-YIG motif/motif A; other site 482957006201 active site 482957006202 catalytic site [active] 482957006203 putative DNA binding site [nucleotide binding]; other site 482957006204 metal binding site [ion binding]; metal-binding site 482957006205 chorismate mutase; Provisional; Region: PRK09269 482957006206 Chorismate mutase type II; Region: CM_2; cl00693 482957006207 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 482957006208 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 482957006209 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957006210 N-terminal plug; other site 482957006211 ligand-binding site [chemical binding]; other site 482957006212 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957006213 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 482957006214 catalytic residues [active] 482957006215 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 482957006216 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957006217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957006218 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957006219 DNA binding residues [nucleotide binding] 482957006220 dimerization interface [polypeptide binding]; other site 482957006221 fructose-1,6-bisphosphatase family protein; Region: PLN02628 482957006222 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 482957006223 AMP binding site [chemical binding]; other site 482957006224 metal binding site [ion binding]; metal-binding site 482957006225 active site 482957006226 aminopeptidase N; Provisional; Region: pepN; PRK14015 482957006227 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 482957006228 active site 482957006229 Zn binding site [ion binding]; other site 482957006230 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 482957006231 Predicted membrane protein [Function unknown]; Region: COG2119 482957006232 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 482957006233 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 482957006234 guanine deaminase; Provisional; Region: PRK09228 482957006235 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 482957006236 active site 482957006237 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 482957006238 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 482957006239 active site 482957006240 purine riboside binding site [chemical binding]; other site 482957006241 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 482957006242 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 482957006243 XdhC Rossmann domain; Region: XdhC_C; pfam13478 482957006244 disulfide bond formation protein B; Provisional; Region: PRK02110 482957006245 amidase; Provisional; Region: PRK07056 482957006246 Amidase; Region: Amidase; cl11426 482957006247 Transcriptional regulators [Transcription]; Region: GntR; COG1802 482957006248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957006249 DNA-binding site [nucleotide binding]; DNA binding site 482957006250 FCD domain; Region: FCD; pfam07729 482957006251 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 482957006252 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 482957006253 catalytic triad [active] 482957006254 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 482957006255 citrate-proton symporter; Provisional; Region: PRK15075 482957006256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957006257 putative substrate translocation pore; other site 482957006258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957006259 binding surface 482957006260 TPR motif; other site 482957006261 TPR repeat; Region: TPR_11; pfam13414 482957006262 TPR repeat; Region: TPR_11; pfam13414 482957006263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957006264 binding surface 482957006265 TPR motif; other site 482957006266 TPR repeat; Region: TPR_11; pfam13414 482957006267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957006268 TPR repeat; Region: TPR_11; pfam13414 482957006269 TPR motif; other site 482957006270 binding surface 482957006271 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957006272 hypothetical protein; Provisional; Region: PRK06184 482957006273 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957006274 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 482957006275 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 482957006276 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957006277 catalytic loop [active] 482957006278 iron binding site [ion binding]; other site 482957006279 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 482957006280 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 482957006281 [4Fe-4S] binding site [ion binding]; other site 482957006282 molybdopterin cofactor binding site; other site 482957006283 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 482957006284 molybdopterin cofactor binding site; other site 482957006285 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 482957006286 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 482957006287 SLBB domain; Region: SLBB; pfam10531 482957006288 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 482957006289 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 482957006290 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 482957006291 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 482957006292 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 482957006293 PBP superfamily domain; Region: PBP_like; pfam12727 482957006294 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957006295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957006296 motif II; other site 482957006297 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 482957006298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957006299 S-adenosylmethionine binding site [chemical binding]; other site 482957006300 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957006301 ligand binding site [chemical binding]; other site 482957006302 DNA gyrase subunit A; Validated; Region: PRK05560 482957006303 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 482957006304 CAP-like domain; other site 482957006305 active site 482957006306 primary dimer interface [polypeptide binding]; other site 482957006307 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 482957006308 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 482957006309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 482957006310 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 482957006311 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 482957006312 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 482957006313 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 482957006314 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 482957006315 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 482957006316 homodimer interface [polypeptide binding]; other site 482957006317 substrate-cofactor binding pocket; other site 482957006318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957006319 catalytic residue [active] 482957006320 Chorismate mutase type II; Region: CM_2; smart00830 482957006321 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 482957006322 Prephenate dehydratase; Region: PDT; pfam00800 482957006323 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 482957006324 putative L-Phe binding site [chemical binding]; other site 482957006325 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 482957006326 prephenate dehydrogenase; Validated; Region: PRK08507 482957006327 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 482957006328 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 482957006329 hinge; other site 482957006330 active site 482957006331 cytidylate kinase; Provisional; Region: cmk; PRK00023 482957006332 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 482957006333 CMP-binding site; other site 482957006334 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 482957006335 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 482957006336 RNA binding site [nucleotide binding]; other site 482957006337 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 482957006338 RNA binding site [nucleotide binding]; other site 482957006339 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 482957006340 RNA binding site [nucleotide binding]; other site 482957006341 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 482957006342 RNA binding site [nucleotide binding]; other site 482957006343 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 482957006344 RNA binding site [nucleotide binding]; other site 482957006345 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 482957006346 RNA binding site [nucleotide binding]; other site 482957006347 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 482957006348 IHF dimer interface [polypeptide binding]; other site 482957006349 IHF - DNA interface [nucleotide binding]; other site 482957006350 tetratricopeptide repeat protein; Provisional; Region: PRK11788 482957006351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957006352 binding surface 482957006353 TPR motif; other site 482957006354 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 482957006355 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 482957006356 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 482957006357 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 482957006358 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 482957006359 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957006360 putative ribose interaction site [chemical binding]; other site 482957006361 putative ADP binding site [chemical binding]; other site 482957006362 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 482957006363 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 482957006364 NADP binding site [chemical binding]; other site 482957006365 homopentamer interface [polypeptide binding]; other site 482957006366 substrate binding site [chemical binding]; other site 482957006367 active site 482957006368 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 482957006369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 482957006370 cysteine synthase B; Region: cysM; TIGR01138 482957006371 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 482957006372 dimer interface [polypeptide binding]; other site 482957006373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957006374 catalytic residue [active] 482957006375 Transglycosylase SLT domain; Region: SLT_2; pfam13406 482957006376 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957006377 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957006378 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 482957006379 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 482957006380 putative active site [active] 482957006381 Zn binding site [ion binding]; other site 482957006382 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 482957006383 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957006384 Serine hydrolase; Region: Ser_hydrolase; cl17834 482957006385 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 482957006386 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 482957006387 Walker A/P-loop; other site 482957006388 ATP binding site [chemical binding]; other site 482957006389 Q-loop/lid; other site 482957006390 ABC transporter signature motif; other site 482957006391 Walker B; other site 482957006392 D-loop; other site 482957006393 H-loop/switch region; other site 482957006394 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 482957006395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006396 dimer interface [polypeptide binding]; other site 482957006397 conserved gate region; other site 482957006398 ABC-ATPase subunit interface; other site 482957006399 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 482957006400 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 482957006401 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 482957006402 Ligand binding site [chemical binding]; other site 482957006403 Electron transfer flavoprotein domain; Region: ETF; pfam01012 482957006404 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 482957006405 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 482957006406 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 482957006407 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 482957006408 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 482957006409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957006410 active site 482957006411 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 482957006412 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 482957006413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957006414 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957006415 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 482957006416 AsnC family; Region: AsnC_trans_reg; pfam01037 482957006417 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 482957006418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957006419 FeS/SAM binding site; other site 482957006420 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 482957006421 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 482957006422 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 482957006423 RimM N-terminal domain; Region: RimM; pfam01782 482957006424 PRC-barrel domain; Region: PRC; pfam05239 482957006425 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 482957006426 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 482957006427 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 482957006428 putative active site [active] 482957006429 putative CoA binding site [chemical binding]; other site 482957006430 nudix motif; other site 482957006431 metal binding site [ion binding]; metal-binding site 482957006432 CobD/CbiB family protein; Provisional; Region: PRK07630 482957006433 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 482957006434 GTPase RsgA; Reviewed; Region: PRK00098 482957006435 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 482957006436 RNA binding site [nucleotide binding]; other site 482957006437 homodimer interface [polypeptide binding]; other site 482957006438 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 482957006439 GTPase/Zn-binding domain interface [polypeptide binding]; other site 482957006440 GTP/Mg2+ binding site [chemical binding]; other site 482957006441 G4 box; other site 482957006442 G5 box; other site 482957006443 G1 box; other site 482957006444 Switch I region; other site 482957006445 G2 box; other site 482957006446 G3 box; other site 482957006447 Switch II region; other site 482957006448 Peptidase family M48; Region: Peptidase_M48; pfam01435 482957006449 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 482957006450 catalytic site [active] 482957006451 putative active site [active] 482957006452 putative substrate binding site [chemical binding]; other site 482957006453 dimer interface [polypeptide binding]; other site 482957006454 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 482957006455 MPT binding site; other site 482957006456 trimer interface [polypeptide binding]; other site 482957006457 hypothetical protein; Provisional; Region: PRK05255 482957006458 peptidase PmbA; Provisional; Region: PRK11040 482957006459 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 482957006460 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 482957006461 folate binding site [chemical binding]; other site 482957006462 NADP+ binding site [chemical binding]; other site 482957006463 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957006464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957006465 Walker A motif; other site 482957006466 ATP binding site [chemical binding]; other site 482957006467 Walker B motif; other site 482957006468 arginine finger; other site 482957006469 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 482957006470 thymidylate synthase; Provisional; Region: thyA; PRK13821 482957006471 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 482957006472 dimerization interface [polypeptide binding]; other site 482957006473 active site 482957006474 FecR protein; Region: FecR; pfam04773 482957006475 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957006476 dimerization interface [polypeptide binding]; other site 482957006477 putative DNA binding site [nucleotide binding]; other site 482957006478 putative Zn2+ binding site [ion binding]; other site 482957006479 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 482957006480 fumarate hydratase; Reviewed; Region: fumC; PRK00485 482957006481 Class II fumarases; Region: Fumarase_classII; cd01362 482957006482 active site 482957006483 tetramer interface [polypeptide binding]; other site 482957006484 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 482957006485 putative efflux protein, MATE family; Region: matE; TIGR00797 482957006486 cation binding site [ion binding]; other site 482957006487 S4 domain; Region: S4_2; pfam13275 482957006488 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 482957006489 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 482957006490 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 482957006491 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957006492 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957006493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957006494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 482957006495 CreA protein; Region: CreA; pfam05981 482957006496 Ferredoxin [Energy production and conversion]; Region: COG1146 482957006497 4Fe-4S binding domain; Region: Fer4; cl02805 482957006498 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 482957006499 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 482957006500 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 482957006501 active site 482957006502 Uncharacterized conserved protein [Function unknown]; Region: COG1556 482957006503 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 482957006504 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 482957006505 transmembrane helices; other site 482957006506 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 482957006507 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 482957006508 dimerization interface [polypeptide binding]; other site 482957006509 ligand binding site [chemical binding]; other site 482957006510 NADP binding site [chemical binding]; other site 482957006511 catalytic site [active] 482957006512 RmuC family; Region: RmuC; pfam02646 482957006513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957006514 Coenzyme A binding pocket [chemical binding]; other site 482957006515 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 482957006516 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 482957006517 dimer interface [polypeptide binding]; other site 482957006518 putative functional site; other site 482957006519 putative MPT binding site; other site 482957006520 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 482957006521 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 482957006522 GTP binding site; other site 482957006523 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 482957006524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957006525 FeS/SAM binding site; other site 482957006526 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 482957006527 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 482957006528 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 482957006529 homodimer interface [polypeptide binding]; other site 482957006530 oligonucleotide binding site [chemical binding]; other site 482957006531 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 482957006532 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957006533 RNA binding surface [nucleotide binding]; other site 482957006534 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 482957006535 active site 482957006536 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 482957006537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957006538 motif II; other site 482957006539 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 482957006540 iron-sulfur cluster [ion binding]; other site 482957006541 [2Fe-2S] cluster binding site [ion binding]; other site 482957006542 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 482957006543 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 482957006544 tandem repeat interface [polypeptide binding]; other site 482957006545 oligomer interface [polypeptide binding]; other site 482957006546 active site residues [active] 482957006547 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 482957006548 putative SAM binding site [chemical binding]; other site 482957006549 homodimer interface [polypeptide binding]; other site 482957006550 Maf-like protein; Region: Maf; pfam02545 482957006551 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 482957006552 active site 482957006553 dimer interface [polypeptide binding]; other site 482957006554 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 482957006555 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 482957006556 putative phosphate acyltransferase; Provisional; Region: PRK05331 482957006557 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 482957006558 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 482957006559 dimer interface [polypeptide binding]; other site 482957006560 active site 482957006561 CoA binding pocket [chemical binding]; other site 482957006562 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 482957006563 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 482957006564 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 482957006565 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 482957006566 NAD(P) binding site [chemical binding]; other site 482957006567 homotetramer interface [polypeptide binding]; other site 482957006568 homodimer interface [polypeptide binding]; other site 482957006569 active site 482957006570 acyl carrier protein; Provisional; Region: acpP; PRK00982 482957006571 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 482957006572 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 482957006573 dimer interface [polypeptide binding]; other site 482957006574 active site 482957006575 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 482957006576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957006577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957006578 DNA binding residues [nucleotide binding] 482957006579 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 482957006580 anti-sigma E factor; Provisional; Region: rseB; PRK09455 482957006581 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 482957006582 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 482957006583 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 482957006584 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957006585 protein binding site [polypeptide binding]; other site 482957006586 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957006587 protein binding site [polypeptide binding]; other site 482957006588 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 482957006589 GTP-binding protein LepA; Provisional; Region: PRK05433 482957006590 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 482957006591 G1 box; other site 482957006592 putative GEF interaction site [polypeptide binding]; other site 482957006593 GTP/Mg2+ binding site [chemical binding]; other site 482957006594 Switch I region; other site 482957006595 G2 box; other site 482957006596 G3 box; other site 482957006597 Switch II region; other site 482957006598 G4 box; other site 482957006599 G5 box; other site 482957006600 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 482957006601 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 482957006602 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 482957006603 signal peptidase I; Provisional; Region: PRK10861 482957006604 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 482957006605 Catalytic site [active] 482957006606 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 482957006607 ribonuclease III; Reviewed; Region: PRK12372 482957006608 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 482957006609 dimerization interface [polypeptide binding]; other site 482957006610 active site 482957006611 metal binding site [ion binding]; metal-binding site 482957006612 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 482957006613 GTPase Era; Reviewed; Region: era; PRK00089 482957006614 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 482957006615 G1 box; other site 482957006616 GTP/Mg2+ binding site [chemical binding]; other site 482957006617 Switch I region; other site 482957006618 G2 box; other site 482957006619 Switch II region; other site 482957006620 G3 box; other site 482957006621 G4 box; other site 482957006622 G5 box; other site 482957006623 KH domain; Region: KH_2; pfam07650 482957006624 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 482957006625 Recombination protein O N terminal; Region: RecO_N; pfam11967 482957006626 Recombination protein O C terminal; Region: RecO_C; pfam02565 482957006627 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 482957006628 active site 482957006629 hydrophilic channel; other site 482957006630 dimerization interface [polypeptide binding]; other site 482957006631 catalytic residues [active] 482957006632 active site lid [active] 482957006633 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 482957006634 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 482957006635 beta-hexosaminidase; Provisional; Region: PRK05337 482957006636 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957006638 active site 482957006639 phosphorylation site [posttranslational modification] 482957006640 intermolecular recognition site; other site 482957006641 dimerization interface [polypeptide binding]; other site 482957006642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957006643 Walker A motif; other site 482957006644 ATP binding site [chemical binding]; other site 482957006645 Walker B motif; other site 482957006646 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957006647 elongation factor P; Validated; Region: PRK00529 482957006648 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 482957006649 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 482957006650 RNA binding site [nucleotide binding]; other site 482957006651 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 482957006652 RNA binding site [nucleotide binding]; other site 482957006653 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 482957006654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 482957006655 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 482957006656 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 482957006657 GIY-YIG motif/motif A; other site 482957006658 active site 482957006659 catalytic site [active] 482957006660 putative DNA binding site [nucleotide binding]; other site 482957006661 metal binding site [ion binding]; metal-binding site 482957006662 UvrB/uvrC motif; Region: UVR; pfam02151 482957006663 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 482957006664 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 482957006665 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 482957006666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957006667 Coenzyme A binding pocket [chemical binding]; other site 482957006668 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 482957006669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957006670 Coenzyme A binding pocket [chemical binding]; other site 482957006671 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957006672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957006673 non-specific DNA binding site [nucleotide binding]; other site 482957006674 salt bridge; other site 482957006675 sequence-specific DNA binding site [nucleotide binding]; other site 482957006676 Cupin domain; Region: Cupin_2; cl17218 482957006677 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 482957006678 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 482957006679 active site 482957006680 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 482957006681 LysR family transcriptional regulator; Provisional; Region: PRK14997 482957006682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957006683 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 482957006684 putative effector binding pocket; other site 482957006685 putative dimerization interface [polypeptide binding]; other site 482957006686 Pirin-related protein [General function prediction only]; Region: COG1741 482957006687 Pirin; Region: Pirin; pfam02678 482957006688 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 482957006689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957006690 Coenzyme A binding pocket [chemical binding]; other site 482957006691 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 482957006692 Protein of unknown function (DUF461); Region: DUF461; pfam04314 482957006693 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 482957006694 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 482957006695 Cu(I) binding site [ion binding]; other site 482957006696 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 482957006697 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 482957006698 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 482957006699 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 482957006700 active site 482957006701 homotetramer interface [polypeptide binding]; other site 482957006702 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 482957006703 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957006704 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 482957006705 Walker A/P-loop; other site 482957006706 ATP binding site [chemical binding]; other site 482957006707 Q-loop/lid; other site 482957006708 ABC transporter signature motif; other site 482957006709 Walker B; other site 482957006710 D-loop; other site 482957006711 H-loop/switch region; other site 482957006712 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 482957006713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957006714 putative ADP-binding pocket [chemical binding]; other site 482957006715 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 482957006716 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 482957006717 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 482957006718 active site 482957006719 tetramer interface [polypeptide binding]; other site 482957006720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957006721 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 482957006722 DNA-binding site [nucleotide binding]; DNA binding site 482957006723 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957006724 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957006725 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957006726 dimerization interface [polypeptide binding]; other site 482957006727 ligand binding site [chemical binding]; other site 482957006728 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957006729 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957006730 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957006731 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957006732 pyridoxamine kinase; Validated; Region: PRK05756 482957006733 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 482957006734 dimer interface [polypeptide binding]; other site 482957006735 pyridoxal binding site [chemical binding]; other site 482957006736 ATP binding site [chemical binding]; other site 482957006737 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 482957006738 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957006739 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 482957006740 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 482957006741 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 482957006742 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 482957006743 ligand binding site; other site 482957006744 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 482957006745 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 482957006746 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 482957006747 B12 binding site [chemical binding]; other site 482957006748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957006749 FeS/SAM binding site; other site 482957006750 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 482957006751 putative active site [active] 482957006752 YdjC motif; other site 482957006753 Mg binding site [ion binding]; other site 482957006754 putative homodimer interface [polypeptide binding]; other site 482957006755 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 482957006756 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 482957006757 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957006758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006759 dimer interface [polypeptide binding]; other site 482957006760 conserved gate region; other site 482957006761 putative PBP binding loops; other site 482957006762 ABC-ATPase subunit interface; other site 482957006763 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957006764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006765 dimer interface [polypeptide binding]; other site 482957006766 conserved gate region; other site 482957006767 putative PBP binding loops; other site 482957006768 ABC-ATPase subunit interface; other site 482957006769 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 482957006770 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957006771 Walker A/P-loop; other site 482957006772 ATP binding site [chemical binding]; other site 482957006773 Q-loop/lid; other site 482957006774 ABC transporter signature motif; other site 482957006775 Walker B; other site 482957006776 D-loop; other site 482957006777 H-loop/switch region; other site 482957006778 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957006779 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 482957006780 conserved cys residue [active] 482957006781 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957006782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957006783 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 482957006784 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957006785 inhibitor-cofactor binding pocket; inhibition site 482957006786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957006787 catalytic residue [active] 482957006788 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 482957006789 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 482957006790 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 482957006791 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 482957006792 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 482957006793 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 482957006794 NAD(P) binding site [chemical binding]; other site 482957006795 catalytic residues [active] 482957006796 succinylarginine dihydrolase; Provisional; Region: PRK13281 482957006797 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 482957006798 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 482957006799 putative active site [active] 482957006800 Zn binding site [ion binding]; other site 482957006801 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 482957006802 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957006803 substrate binding pocket [chemical binding]; other site 482957006804 membrane-bound complex binding site; other site 482957006805 hinge residues; other site 482957006806 HDOD domain; Region: HDOD; pfam08668 482957006807 PAS domain; Region: PAS_9; pfam13426 482957006808 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 482957006809 putative active site [active] 482957006810 heme pocket [chemical binding]; other site 482957006811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957006812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957006813 metal binding site [ion binding]; metal-binding site 482957006814 active site 482957006815 I-site; other site 482957006816 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957006817 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 482957006818 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957006819 catalytic triad [active] 482957006820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957006821 NADH(P)-binding; Region: NAD_binding_10; pfam13460 482957006822 NAD(P) binding site [chemical binding]; other site 482957006823 active site 482957006824 NYN domain; Region: NYN; pfam01936 482957006825 putative metal binding site [ion binding]; other site 482957006826 Uncharacterized conserved protein [Function unknown]; Region: COG1432 482957006827 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 482957006828 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 482957006829 active site 482957006830 metal binding site [ion binding]; metal-binding site 482957006831 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 482957006832 Protein export membrane protein; Region: SecD_SecF; cl14618 482957006833 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 482957006834 Protein export membrane protein; Region: SecD_SecF; cl14618 482957006835 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 482957006836 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957006837 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957006838 possible frameshift; similar to IclR-family transcriptional regulatory protein 482957006839 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957006840 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957006841 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 482957006842 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 482957006843 Predicted transcriptional regulator [Transcription]; Region: COG1959 482957006844 Transcriptional regulator; Region: Rrf2; pfam02082 482957006845 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 482957006846 NADH(P)-binding; Region: NAD_binding_10; pfam13460 482957006847 NAD binding site [chemical binding]; other site 482957006848 substrate binding site [chemical binding]; other site 482957006849 putative active site [active] 482957006850 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957006851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957006852 putative DNA binding site [nucleotide binding]; other site 482957006853 putative Zn2+ binding site [ion binding]; other site 482957006854 AsnC family; Region: AsnC_trans_reg; pfam01037 482957006855 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 482957006856 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 482957006857 Walker A/P-loop; other site 482957006858 ATP binding site [chemical binding]; other site 482957006859 Q-loop/lid; other site 482957006860 ABC transporter signature motif; other site 482957006861 Walker B; other site 482957006862 D-loop; other site 482957006863 H-loop/switch region; other site 482957006864 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 482957006865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006866 dimer interface [polypeptide binding]; other site 482957006867 conserved gate region; other site 482957006868 putative PBP binding loops; other site 482957006869 ABC-ATPase subunit interface; other site 482957006870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006871 dimer interface [polypeptide binding]; other site 482957006872 conserved gate region; other site 482957006873 putative PBP binding loops; other site 482957006874 ABC-ATPase subunit interface; other site 482957006875 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 482957006876 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 482957006877 putative proline-specific permease; Provisional; Region: proY; PRK10580 482957006878 Spore germination protein; Region: Spore_permease; cl17796 482957006879 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 482957006880 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 482957006881 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 482957006882 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 482957006883 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 482957006884 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 482957006885 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 482957006886 Family description; Region: UvrD_C_2; pfam13538 482957006887 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 482957006888 AAA domain; Region: AAA_30; pfam13604 482957006889 Family description; Region: UvrD_C_2; pfam13538 482957006890 hypothetical protein; Provisional; Region: PRK09256 482957006891 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 482957006892 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957006893 EamA-like transporter family; Region: EamA; pfam00892 482957006894 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 482957006895 EamA-like transporter family; Region: EamA; pfam00892 482957006896 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 482957006897 ThiC-associated domain; Region: ThiC-associated; pfam13667 482957006898 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 482957006899 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 482957006900 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 482957006901 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 482957006902 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 482957006903 Moco binding site; other site 482957006904 metal coordination site [ion binding]; other site 482957006905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957006906 non-specific DNA binding site [nucleotide binding]; other site 482957006907 salt bridge; other site 482957006908 sequence-specific DNA binding site [nucleotide binding]; other site 482957006909 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 482957006910 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 482957006911 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957006912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957006913 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 482957006914 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 482957006915 active site 482957006916 metal binding site [ion binding]; metal-binding site 482957006917 hexamer interface [polypeptide binding]; other site 482957006918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957006919 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 482957006920 Walker A/P-loop; other site 482957006921 ATP binding site [chemical binding]; other site 482957006922 Q-loop/lid; other site 482957006923 ABC transporter signature motif; other site 482957006924 Walker B; other site 482957006925 D-loop; other site 482957006926 H-loop/switch region; other site 482957006927 TOBE domain; Region: TOBE_2; pfam08402 482957006928 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957006929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006930 dimer interface [polypeptide binding]; other site 482957006931 conserved gate region; other site 482957006932 putative PBP binding loops; other site 482957006933 ABC-ATPase subunit interface; other site 482957006934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957006935 dimer interface [polypeptide binding]; other site 482957006936 conserved gate region; other site 482957006937 ABC-ATPase subunit interface; other site 482957006938 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957006939 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 482957006940 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957006941 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957006942 DNA binding site [nucleotide binding] 482957006943 domain linker motif; other site 482957006944 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 482957006945 putative dimerization interface [polypeptide binding]; other site 482957006946 putative ligand binding site [chemical binding]; other site 482957006947 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957006948 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957006949 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 482957006950 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957006951 N-terminal plug; other site 482957006952 ligand-binding site [chemical binding]; other site 482957006953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 482957006954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957006955 dimer interface [polypeptide binding]; other site 482957006956 phosphorylation site [posttranslational modification] 482957006957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957006958 ATP binding site [chemical binding]; other site 482957006959 Mg2+ binding site [ion binding]; other site 482957006960 G-X-G motif; other site 482957006961 Uncharacterized conserved protein [Function unknown]; Region: COG5476 482957006962 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 482957006963 MlrC C-terminus; Region: MlrC_C; pfam07171 482957006964 D-aminopeptidase; Reviewed; Region: PRK13128 482957006965 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957006966 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 482957006967 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 482957006968 active site 482957006969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957006970 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957006971 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957006972 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957006973 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957006974 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 482957006975 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 482957006976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957006977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957006978 active site 482957006979 phosphorylation site [posttranslational modification] 482957006980 intermolecular recognition site; other site 482957006981 dimerization interface [polypeptide binding]; other site 482957006982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957006983 DNA binding site [nucleotide binding] 482957006984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957006985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957006986 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 482957006987 putative effector binding pocket; other site 482957006988 putative dimerization interface [polypeptide binding]; other site 482957006989 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 482957006990 Cinnamyl alcohol dehydrogenases (CAD) and related proteins; Region: CAD; cd08245 482957006991 NAD binding site [chemical binding]; other site 482957006992 substrate binding site [chemical binding]; other site 482957006993 catalytic Zn binding site [ion binding]; other site 482957006994 structural Zn binding site [ion binding]; other site 482957006995 tetramer interface [polypeptide binding]; other site 482957006996 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 482957006997 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 482957006998 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 482957006999 tetramer interface [polypeptide binding]; other site 482957007000 TPP-binding site [chemical binding]; other site 482957007001 heterodimer interface [polypeptide binding]; other site 482957007002 phosphorylation loop region [posttranslational modification] 482957007003 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 482957007004 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 482957007005 alpha subunit interface [polypeptide binding]; other site 482957007006 TPP binding site [chemical binding]; other site 482957007007 heterodimer interface [polypeptide binding]; other site 482957007008 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 482957007009 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 482957007010 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957007011 E3 interaction surface; other site 482957007012 lipoyl attachment site [posttranslational modification]; other site 482957007013 e3 binding domain; Region: E3_binding; pfam02817 482957007014 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 482957007015 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 482957007016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957007017 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957007018 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 482957007019 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 482957007020 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 482957007021 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 482957007022 choline dehydrogenase; Validated; Region: PRK02106 482957007023 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957007024 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957007025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957007028 dimerization interface [polypeptide binding]; other site 482957007029 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 482957007030 Zn2+ binding site [ion binding]; other site 482957007031 intersubunit interface [polypeptide binding]; other site 482957007032 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957007033 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 482957007034 NAD(P) binding site [chemical binding]; other site 482957007035 catalytic residues [active] 482957007036 catalytic residues [active] 482957007037 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957007038 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957007039 trimer interface [polypeptide binding]; other site 482957007040 eyelet of channel; other site 482957007041 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 482957007042 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957007043 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957007044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957007045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957007046 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 482957007047 YadA-like C-terminal region; Region: YadA; pfam03895 482957007048 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 482957007049 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 482957007050 NAD binding site [chemical binding]; other site 482957007051 active site 482957007052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957007055 dimerization interface [polypeptide binding]; other site 482957007056 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 482957007057 agmatinase; Region: agmatinase; TIGR01230 482957007058 oligomer interface [polypeptide binding]; other site 482957007059 putative active site [active] 482957007060 Mn binding site [ion binding]; other site 482957007061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957007062 Coenzyme A binding pocket [chemical binding]; other site 482957007063 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 482957007064 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 482957007065 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957007066 Na binding site [ion binding]; other site 482957007067 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957007068 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957007069 trimer interface [polypeptide binding]; other site 482957007070 eyelet of channel; other site 482957007071 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957007072 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957007073 trimer interface [polypeptide binding]; other site 482957007074 eyelet of channel; other site 482957007075 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 482957007076 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957007077 Na binding site [ion binding]; other site 482957007078 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957007079 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957007080 metal binding site [ion binding]; metal-binding site 482957007081 putative dimer interface [polypeptide binding]; other site 482957007082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957007085 dimerization interface [polypeptide binding]; other site 482957007086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957007089 dimerization interface [polypeptide binding]; other site 482957007090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007091 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957007092 putative substrate translocation pore; other site 482957007093 allantoate amidohydrolase; Reviewed; Region: PRK12893 482957007094 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 482957007095 active site 482957007096 metal binding site [ion binding]; metal-binding site 482957007097 dimer interface [polypeptide binding]; other site 482957007098 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 482957007099 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 482957007100 active site 482957007101 Zn binding site [ion binding]; other site 482957007102 Spore Coat Protein U domain; Region: SCPU; pfam05229 482957007103 Uncharacterized secreted protein [Function unknown]; Region: COG5430 482957007104 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 482957007105 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 482957007106 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 482957007107 PapC C-terminal domain; Region: PapC_C; pfam13953 482957007108 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 482957007109 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 482957007110 Uncharacterized secreted protein [Function unknown]; Region: COG5430 482957007111 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957007112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007113 putative substrate translocation pore; other site 482957007114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007116 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957007117 dimerization interface [polypeptide binding]; other site 482957007118 substrate binding pocket [chemical binding]; other site 482957007119 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 482957007120 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 482957007121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957007122 catalytic residue [active] 482957007123 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 482957007124 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 482957007125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957007127 dimerization interface [polypeptide binding]; other site 482957007128 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 482957007129 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 482957007130 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 482957007131 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 482957007132 putative dimer interface [polypeptide binding]; other site 482957007133 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 482957007134 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 482957007135 putative dimer interface [polypeptide binding]; other site 482957007136 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 482957007137 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957007138 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957007139 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957007140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007141 LysR substrate binding domain; Region: LysR_substrate; pfam03466 482957007142 dimerization interface [polypeptide binding]; other site 482957007143 Malonate transporter MadL subunit; Region: MadL; cl04273 482957007144 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 482957007145 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 482957007146 Coenzyme A transferase; Region: CoA_trans; cl17247 482957007147 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 482957007148 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 482957007149 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 482957007150 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 482957007151 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 482957007152 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 482957007153 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 482957007154 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 482957007155 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 482957007156 putative active site [active] 482957007157 catalytic site [active] 482957007158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957007159 active site 482957007160 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 482957007161 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 482957007162 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957007163 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 482957007164 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 482957007165 N-terminal domain interface [polypeptide binding]; other site 482957007166 dimer interface [polypeptide binding]; other site 482957007167 substrate binding pocket (H-site) [chemical binding]; other site 482957007168 proline/glycine betaine transporter; Provisional; Region: PRK10642 482957007169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007170 putative substrate translocation pore; other site 482957007171 hypothetical protein; Provisional; Region: PRK02237 482957007172 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 482957007173 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 482957007174 active site 482957007175 catalytic site [active] 482957007176 substrate binding site [chemical binding]; other site 482957007177 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 482957007178 RNA/DNA hybrid binding site [nucleotide binding]; other site 482957007179 active site 482957007180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957007181 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 482957007182 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 482957007183 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957007184 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957007185 catalytic residue [active] 482957007186 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 482957007187 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957007188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957007190 putative substrate translocation pore; other site 482957007191 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 482957007192 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 482957007193 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 482957007194 catalytic site [active] 482957007195 subunit interface [polypeptide binding]; other site 482957007196 leucine export protein LeuE; Provisional; Region: PRK10958 482957007197 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 482957007198 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 482957007199 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 482957007200 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 482957007201 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 482957007202 ATP-grasp domain; Region: ATP-grasp_4; cl17255 482957007203 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 482957007204 IMP binding site; other site 482957007205 dimer interface [polypeptide binding]; other site 482957007206 interdomain contacts; other site 482957007207 partial ornithine binding site; other site 482957007208 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 482957007209 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 482957007210 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 482957007211 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 482957007212 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 482957007213 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 482957007214 FtsJ-like methyltransferase; Region: FtsJ; cl17430 482957007215 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 482957007216 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957007217 Walker A motif; other site 482957007218 ATP binding site [chemical binding]; other site 482957007219 Walker B motif; other site 482957007220 arginine finger; other site 482957007221 Peptidase family M41; Region: Peptidase_M41; pfam01434 482957007222 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 482957007223 dihydropteroate synthase; Region: DHPS; TIGR01496 482957007224 substrate binding pocket [chemical binding]; other site 482957007225 dimer interface [polypeptide binding]; other site 482957007226 inhibitor binding site; inhibition site 482957007227 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 482957007228 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 482957007229 active site 482957007230 substrate binding site [chemical binding]; other site 482957007231 metal binding site [ion binding]; metal-binding site 482957007232 PBP superfamily domain; Region: PBP_like_2; cl17296 482957007233 PBP superfamily domain; Region: PBP_like_2; cl17296 482957007234 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 482957007235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957007236 dimer interface [polypeptide binding]; other site 482957007237 conserved gate region; other site 482957007238 putative PBP binding loops; other site 482957007239 ABC-ATPase subunit interface; other site 482957007240 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 482957007241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957007242 dimer interface [polypeptide binding]; other site 482957007243 conserved gate region; other site 482957007244 putative PBP binding loops; other site 482957007245 ABC-ATPase subunit interface; other site 482957007246 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 482957007247 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 482957007248 Walker A/P-loop; other site 482957007249 ATP binding site [chemical binding]; other site 482957007250 Q-loop/lid; other site 482957007251 ABC transporter signature motif; other site 482957007252 Walker B; other site 482957007253 D-loop; other site 482957007254 H-loop/switch region; other site 482957007255 transcriptional regulator PhoU; Provisional; Region: PRK11115 482957007256 PhoU domain; Region: PhoU; pfam01895 482957007257 PhoU domain; Region: PhoU; pfam01895 482957007258 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 482957007259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957007260 active site 482957007261 phosphorylation site [posttranslational modification] 482957007262 intermolecular recognition site; other site 482957007263 dimerization interface [polypeptide binding]; other site 482957007264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957007265 DNA binding site [nucleotide binding] 482957007266 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 482957007267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 482957007268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957007269 dimer interface [polypeptide binding]; other site 482957007270 phosphorylation site [posttranslational modification] 482957007271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957007272 ATP binding site [chemical binding]; other site 482957007273 Mg2+ binding site [ion binding]; other site 482957007274 G-X-G motif; other site 482957007275 polyphosphate kinase; Provisional; Region: PRK05443 482957007276 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 482957007277 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 482957007278 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 482957007279 putative active site [active] 482957007280 catalytic site [active] 482957007281 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 482957007282 putative domain interface [polypeptide binding]; other site 482957007283 putative active site [active] 482957007284 catalytic site [active] 482957007285 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 482957007286 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 482957007287 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 482957007288 catalytic core [active] 482957007289 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 482957007290 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 482957007291 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 482957007292 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 482957007293 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 482957007294 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 482957007295 active site 482957007296 acyl-activating enzyme (AAE) consensus motif; other site 482957007297 putative CoA binding site [chemical binding]; other site 482957007298 AMP binding site [chemical binding]; other site 482957007299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957007300 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 482957007301 Peptidase family M23; Region: Peptidase_M23; pfam01551 482957007302 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 482957007303 active site 482957007304 catalytic residues [active] 482957007305 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 482957007306 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 482957007307 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 482957007308 glutaminase active site [active] 482957007309 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 482957007310 dimer interface [polypeptide binding]; other site 482957007311 active site 482957007312 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 482957007313 dimer interface [polypeptide binding]; other site 482957007314 active site 482957007315 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 482957007316 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 482957007317 active site 482957007318 homodimer interface [polypeptide binding]; other site 482957007319 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 482957007320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957007323 dimerization interface [polypeptide binding]; other site 482957007324 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957007325 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957007326 dimerization interface [polypeptide binding]; other site 482957007327 ligand binding site [chemical binding]; other site 482957007328 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 482957007329 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957007330 catalytic loop [active] 482957007331 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 482957007332 iron binding site [ion binding]; other site 482957007333 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957007334 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957007335 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957007336 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 482957007337 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957007338 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957007339 aldolase II superfamily protein; Provisional; Region: PRK07044 482957007340 intersubunit interface [polypeptide binding]; other site 482957007341 active site 482957007342 Zn2+ binding site [ion binding]; other site 482957007343 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 482957007344 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 482957007345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957007346 active site 482957007347 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 482957007348 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957007349 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 482957007350 NAD(P) binding site [chemical binding]; other site 482957007351 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 482957007352 active site 482957007353 catalytic triad [active] 482957007354 oxyanion hole [active] 482957007355 Predicted transcriptional regulators [Transcription]; Region: COG1695 482957007356 Transcriptional regulator PadR-like family; Region: PadR; cl17335 482957007357 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 482957007358 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957007359 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 482957007360 active site 482957007361 FMN binding site [chemical binding]; other site 482957007362 2,4-decadienoyl-CoA binding site; other site 482957007363 catalytic residue [active] 482957007364 4Fe-4S cluster binding site [ion binding]; other site 482957007365 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 482957007366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957007367 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957007368 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957007369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957007370 DNA-binding site [nucleotide binding]; DNA binding site 482957007371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957007372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957007373 homodimer interface [polypeptide binding]; other site 482957007374 catalytic residue [active] 482957007375 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 482957007376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957007377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957007378 homodimer interface [polypeptide binding]; other site 482957007379 catalytic residue [active] 482957007380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957007381 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957007382 substrate binding pocket [chemical binding]; other site 482957007383 membrane-bound complex binding site; other site 482957007384 hinge residues; other site 482957007385 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957007386 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957007387 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 482957007388 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957007389 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957007390 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 482957007391 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 482957007392 active site 482957007393 dimer interface [polypeptide binding]; other site 482957007394 metal binding site [ion binding]; metal-binding site 482957007395 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 482957007396 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 482957007397 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 482957007398 dimer interface [polypeptide binding]; other site 482957007399 active site 482957007400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007402 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957007403 putative effector binding pocket; other site 482957007404 dimerization interface [polypeptide binding]; other site 482957007405 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 482957007406 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957007407 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957007408 N-terminal plug; other site 482957007409 ligand-binding site [chemical binding]; other site 482957007410 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 482957007411 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 482957007412 Walker A/P-loop; other site 482957007413 ATP binding site [chemical binding]; other site 482957007414 Q-loop/lid; other site 482957007415 ABC transporter signature motif; other site 482957007416 Walker B; other site 482957007417 D-loop; other site 482957007418 H-loop/switch region; other site 482957007419 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 482957007420 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 482957007421 putative ligand binding residues [chemical binding]; other site 482957007422 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 482957007423 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 482957007424 dimer interface [polypeptide binding]; other site 482957007425 putative PBP binding regions; other site 482957007426 ABC-ATPase subunit interface; other site 482957007427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957007428 dimerization interface [polypeptide binding]; other site 482957007429 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 482957007430 dimer interface [polypeptide binding]; other site 482957007431 phosphorylation site [posttranslational modification] 482957007432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957007433 ATP binding site [chemical binding]; other site 482957007434 Mg2+ binding site [ion binding]; other site 482957007435 G-X-G motif; other site 482957007436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957007438 active site 482957007439 phosphorylation site [posttranslational modification] 482957007440 intermolecular recognition site; other site 482957007441 dimerization interface [polypeptide binding]; other site 482957007442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957007443 DNA binding site [nucleotide binding] 482957007444 MltA-interacting protein MipA; Region: MipA; cl01504 482957007445 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 482957007446 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957007447 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957007448 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957007449 catalytic residue [active] 482957007450 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 482957007451 VirB7 interaction site; other site 482957007452 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957007453 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957007454 trimer interface [polypeptide binding]; other site 482957007455 eyelet of channel; other site 482957007456 RNA polymerase sigma factor; Provisional; Region: PRK12528 482957007457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957007458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957007459 DNA binding residues [nucleotide binding] 482957007460 fec operon regulator FecR; Reviewed; Region: PRK09774 482957007461 FecR protein; Region: FecR; pfam04773 482957007462 Secretin and TonB N terminus short domain; Region: STN; smart00965 482957007463 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957007464 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957007465 N-terminal plug; other site 482957007466 ligand-binding site [chemical binding]; other site 482957007467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007469 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 482957007470 putative dimerization interface [polypeptide binding]; other site 482957007471 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 482957007472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957007473 putative metal binding site [ion binding]; other site 482957007474 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 482957007475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007477 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 482957007478 putative dimerization interface [polypeptide binding]; other site 482957007479 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 482957007480 Citrate transporter; Region: CitMHS; pfam03600 482957007481 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 482957007482 Predicted amidohydrolase [General function prediction only]; Region: COG0388 482957007483 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 482957007484 active site 482957007485 catalytic triad [active] 482957007486 dimer interface [polypeptide binding]; other site 482957007487 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957007488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957007489 DNA binding residues [nucleotide binding] 482957007490 dimerization interface [polypeptide binding]; other site 482957007491 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 482957007492 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 482957007493 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 482957007494 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 482957007495 putative acyl-acceptor binding pocket; other site 482957007496 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 482957007497 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 482957007498 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957007499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957007500 S-adenosylmethionine binding site [chemical binding]; other site 482957007501 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 482957007502 active site 482957007503 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 482957007504 active site 482957007505 catalytic residues [active] 482957007506 GAF domain; Region: GAF_2; pfam13185 482957007507 GAF domain; Region: GAF; pfam01590 482957007508 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957007509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957007510 metal binding site [ion binding]; metal-binding site 482957007511 active site 482957007512 I-site; other site 482957007513 cellulose synthase regulator protein; Provisional; Region: PRK11114 482957007514 endo-1,4-D-glucanase; Provisional; Region: PRK11097 482957007515 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 482957007516 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 482957007517 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 482957007518 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 482957007519 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 482957007520 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 482957007521 DXD motif; other site 482957007522 PilZ domain; Region: PilZ; pfam07238 482957007523 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 482957007524 Pirin-related protein [General function prediction only]; Region: COG1741 482957007525 Pirin; Region: Pirin; pfam02678 482957007526 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 482957007527 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 482957007528 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 482957007529 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 482957007530 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 482957007531 Isochorismatase family; Region: Isochorismatase; pfam00857 482957007532 catalytic triad [active] 482957007533 dimer interface [polypeptide binding]; other site 482957007534 conserved cis-peptide bond; other site 482957007535 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007537 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957007538 putative effector binding pocket; other site 482957007539 dimerization interface [polypeptide binding]; other site 482957007540 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 482957007541 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 482957007542 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 482957007543 active site 482957007544 Predicted membrane protein [Function unknown]; Region: COG2259 482957007545 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 482957007546 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 482957007547 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 482957007548 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 482957007549 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 482957007550 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 482957007551 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 482957007552 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 482957007553 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 482957007554 nudix motif; other site 482957007555 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 482957007556 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957007557 active site 482957007558 HIGH motif; other site 482957007559 nucleotide binding site [chemical binding]; other site 482957007560 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957007561 active site 482957007562 KMSKS motif; other site 482957007563 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 482957007564 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 482957007565 Serine hydrolase; Region: Ser_hydrolase; pfam06821 482957007566 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957007567 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957007568 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 482957007569 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 482957007570 motif 1; other site 482957007571 active site 482957007572 motif 2; other site 482957007573 motif 3; other site 482957007574 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 482957007575 DHHA1 domain; Region: DHHA1; pfam02272 482957007576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957007579 dimerization interface [polypeptide binding]; other site 482957007580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957007582 putative substrate translocation pore; other site 482957007583 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 482957007584 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 482957007585 nudix motif; other site 482957007586 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 482957007587 active site 482957007588 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957007589 TM-ABC transporter signature motif; other site 482957007590 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 482957007591 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957007592 TM-ABC transporter signature motif; other site 482957007593 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 482957007594 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957007595 Walker A/P-loop; other site 482957007596 ATP binding site [chemical binding]; other site 482957007597 Q-loop/lid; other site 482957007598 ABC transporter signature motif; other site 482957007599 Walker B; other site 482957007600 D-loop; other site 482957007601 H-loop/switch region; other site 482957007602 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957007603 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 482957007604 Walker A/P-loop; other site 482957007605 ATP binding site [chemical binding]; other site 482957007606 Q-loop/lid; other site 482957007607 ABC transporter signature motif; other site 482957007608 Walker B; other site 482957007609 D-loop; other site 482957007610 H-loop/switch region; other site 482957007611 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 482957007612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957007613 NAD(P) binding site [chemical binding]; other site 482957007614 active site 482957007615 hypothetical protein; Provisional; Region: PRK02487 482957007616 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 482957007617 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 482957007618 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 482957007619 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957007620 dimer interface [polypeptide binding]; other site 482957007621 PYR/PP interface [polypeptide binding]; other site 482957007622 TPP binding site [chemical binding]; other site 482957007623 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957007624 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 482957007625 TPP-binding site [chemical binding]; other site 482957007626 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957007627 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 482957007628 substrate binding site [chemical binding]; other site 482957007629 ATP binding site [chemical binding]; other site 482957007630 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 482957007631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 482957007632 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 482957007633 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 482957007634 putative ligand binding site [chemical binding]; other site 482957007635 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 482957007636 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957007637 Walker A/P-loop; other site 482957007638 ATP binding site [chemical binding]; other site 482957007639 Q-loop/lid; other site 482957007640 ABC transporter signature motif; other site 482957007641 Walker B; other site 482957007642 D-loop; other site 482957007643 H-loop/switch region; other site 482957007644 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957007645 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957007646 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957007647 TM-ABC transporter signature motif; other site 482957007648 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 482957007649 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 482957007650 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 482957007651 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 482957007652 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 482957007653 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 482957007654 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 482957007655 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 482957007656 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 482957007657 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957007658 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 482957007659 putative active site [active] 482957007660 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 482957007661 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 482957007662 tetrameric interface [polypeptide binding]; other site 482957007663 NAD binding site [chemical binding]; other site 482957007664 catalytic residues [active] 482957007665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007667 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957007668 putative effector binding pocket; other site 482957007669 dimerization interface [polypeptide binding]; other site 482957007670 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 482957007671 CPxP motif; other site 482957007672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957007673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957007674 active site 482957007675 phosphorylation site [posttranslational modification] 482957007676 intermolecular recognition site; other site 482957007677 dimerization interface [polypeptide binding]; other site 482957007678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957007679 DNA binding site [nucleotide binding] 482957007680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 482957007681 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957007682 FecR protein; Region: FecR; pfam04773 482957007683 CHASE2 domain; Region: CHASE2; pfam05226 482957007684 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 482957007685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957007686 dimer interface [polypeptide binding]; other site 482957007687 phosphorylation site [posttranslational modification] 482957007688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957007689 ATP binding site [chemical binding]; other site 482957007690 Mg2+ binding site [ion binding]; other site 482957007691 G-X-G motif; other site 482957007692 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 482957007693 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 482957007694 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 482957007695 active site 482957007696 tetramer interface; other site 482957007697 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 482957007698 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 482957007699 HIGH motif; other site 482957007700 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 482957007701 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 482957007702 active site 482957007703 KMSKS motif; other site 482957007704 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 482957007705 tRNA binding surface [nucleotide binding]; other site 482957007706 anticodon binding site; other site 482957007707 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 482957007708 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 482957007709 Part of AAA domain; Region: AAA_19; pfam13245 482957007710 Family description; Region: UvrD_C_2; pfam13538 482957007711 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 482957007712 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 482957007713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957007715 putative substrate translocation pore; other site 482957007716 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 482957007717 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957007718 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957007719 dimer interface [polypeptide binding]; other site 482957007720 putative CheW interface [polypeptide binding]; other site 482957007721 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 482957007722 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957007723 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957007724 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 482957007725 Fusaric acid resistance protein family; Region: FUSC; pfam04632 482957007726 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 482957007727 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957007728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007730 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957007731 putative effector binding pocket; other site 482957007732 dimerization interface [polypeptide binding]; other site 482957007733 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 482957007734 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 482957007735 putative active site [active] 482957007736 putative metal binding site [ion binding]; other site 482957007737 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957007738 FAD binding domain; Region: FAD_binding_4; pfam01565 482957007739 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 482957007740 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957007741 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957007742 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 482957007743 Protein of unknown function (DUF962); Region: DUF962; cl01879 482957007744 FOG: CBS domain [General function prediction only]; Region: COG0517 482957007745 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 482957007746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007747 putative substrate translocation pore; other site 482957007748 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 482957007749 putative acyl-acceptor binding pocket; other site 482957007750 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 482957007751 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 482957007752 Tetramer interface [polypeptide binding]; other site 482957007753 active site 482957007754 FMN-binding site [chemical binding]; other site 482957007755 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 482957007756 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957007757 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 482957007758 short chain dehydrogenase; Provisional; Region: PRK06949 482957007759 classical (c) SDRs; Region: SDR_c; cd05233 482957007760 NAD(P) binding site [chemical binding]; other site 482957007761 active site 482957007762 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 482957007763 active site 482957007764 PAS domain; Region: PAS_9; pfam13426 482957007765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957007766 putative active site [active] 482957007767 heme pocket [chemical binding]; other site 482957007768 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957007769 DNA binding residues [nucleotide binding] 482957007770 dimerization interface [polypeptide binding]; other site 482957007771 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 482957007772 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 482957007773 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957007774 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957007775 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 482957007776 homotrimer interaction site [polypeptide binding]; other site 482957007777 putative active site [active] 482957007778 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 482957007779 HD domain; Region: HD_4; pfam13328 482957007780 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 482957007781 synthetase active site [active] 482957007782 NTP binding site [chemical binding]; other site 482957007783 metal binding site [ion binding]; metal-binding site 482957007784 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 482957007785 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 482957007786 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 482957007787 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 482957007788 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 482957007789 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 482957007790 active site 482957007791 dimer interface [polypeptide binding]; other site 482957007792 motif 1; other site 482957007793 motif 2; other site 482957007794 motif 3; other site 482957007795 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 482957007796 anticodon binding site; other site 482957007797 translation initiation factor IF-3; Region: infC; TIGR00168 482957007798 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 482957007799 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 482957007800 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 482957007801 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 482957007802 23S rRNA binding site [nucleotide binding]; other site 482957007803 L21 binding site [polypeptide binding]; other site 482957007804 L13 binding site [polypeptide binding]; other site 482957007805 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 482957007806 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 482957007807 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 482957007808 dimer interface [polypeptide binding]; other site 482957007809 motif 1; other site 482957007810 active site 482957007811 motif 2; other site 482957007812 motif 3; other site 482957007813 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 482957007814 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 482957007815 putative tRNA-binding site [nucleotide binding]; other site 482957007816 B3/4 domain; Region: B3_4; pfam03483 482957007817 tRNA synthetase B5 domain; Region: B5; smart00874 482957007818 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 482957007819 dimer interface [polypeptide binding]; other site 482957007820 motif 1; other site 482957007821 motif 3; other site 482957007822 motif 2; other site 482957007823 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 482957007824 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 482957007825 IHF dimer interface [polypeptide binding]; other site 482957007826 IHF - DNA interface [nucleotide binding]; other site 482957007827 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 482957007828 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 482957007829 DNA binding residues [nucleotide binding] 482957007830 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 482957007831 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 482957007832 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957007833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 482957007834 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 482957007835 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 482957007836 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 482957007837 Uncharacterized conserved protein [Function unknown]; Region: COG1359 482957007838 Uncharacterized conserved protein [Function unknown]; Region: COG1434 482957007839 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 482957007840 putative active site [active] 482957007841 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 482957007842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957007843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957007844 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 482957007845 putative dimerization interface [polypeptide binding]; other site 482957007846 possible frameshift; similar to aminotransferase, class I and II 482957007847 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 482957007848 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 482957007849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957007850 RNA binding surface [nucleotide binding]; other site 482957007851 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 482957007852 probable active site [active] 482957007853 ribosome maturation protein RimP; Reviewed; Region: PRK00092 482957007854 Sm and related proteins; Region: Sm_like; cl00259 482957007855 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 482957007856 putative oligomer interface [polypeptide binding]; other site 482957007857 putative RNA binding site [nucleotide binding]; other site 482957007858 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 482957007859 NusA N-terminal domain; Region: NusA_N; pfam08529 482957007860 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 482957007861 RNA binding site [nucleotide binding]; other site 482957007862 homodimer interface [polypeptide binding]; other site 482957007863 NusA-like KH domain; Region: KH_5; pfam13184 482957007864 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 482957007865 G-X-X-G motif; other site 482957007866 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 482957007867 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 482957007868 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 482957007869 translation initiation factor IF-2; Region: IF-2; TIGR00487 482957007870 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 482957007871 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 482957007872 G1 box; other site 482957007873 putative GEF interaction site [polypeptide binding]; other site 482957007874 GTP/Mg2+ binding site [chemical binding]; other site 482957007875 Switch I region; other site 482957007876 G2 box; other site 482957007877 G3 box; other site 482957007878 Switch II region; other site 482957007879 G4 box; other site 482957007880 G5 box; other site 482957007881 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 482957007882 Translation-initiation factor 2; Region: IF-2; pfam11987 482957007883 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 482957007884 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 482957007885 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 482957007886 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 482957007887 RNA binding site [nucleotide binding]; other site 482957007888 active site 482957007889 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 482957007890 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957007891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007892 putative substrate translocation pore; other site 482957007893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007894 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 482957007895 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957007896 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957007897 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957007898 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957007899 MarR family; Region: MarR_2; cl17246 482957007900 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 482957007901 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 482957007902 G1 box; other site 482957007903 putative GEF interaction site [polypeptide binding]; other site 482957007904 GTP/Mg2+ binding site [chemical binding]; other site 482957007905 Switch I region; other site 482957007906 G2 box; other site 482957007907 G3 box; other site 482957007908 Switch II region; other site 482957007909 G4 box; other site 482957007910 G5 box; other site 482957007911 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 482957007912 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 482957007913 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 482957007914 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 482957007915 TPP-binding site [chemical binding]; other site 482957007916 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 482957007917 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 482957007918 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957007919 E3 interaction surface; other site 482957007920 lipoyl attachment site [posttranslational modification]; other site 482957007921 e3 binding domain; Region: E3_binding; pfam02817 482957007922 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 482957007923 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 482957007924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957007925 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 482957007926 Predicted ATPase [General function prediction only]; Region: COG1485 482957007927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957007928 Walker B; other site 482957007929 D-loop; other site 482957007930 H-loop/switch region; other site 482957007931 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 482957007932 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 482957007933 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 482957007934 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 482957007935 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 482957007936 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 482957007937 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 482957007938 TadE-like protein; Region: TadE; pfam07811 482957007939 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 482957007940 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 482957007941 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 482957007942 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 482957007943 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 482957007944 AAA domain; Region: AAA_31; pfam13614 482957007945 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 482957007946 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 482957007947 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 482957007948 ATP binding site [chemical binding]; other site 482957007949 Walker A motif; other site 482957007950 hexamer interface [polypeptide binding]; other site 482957007951 Walker B motif; other site 482957007952 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 482957007953 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957007954 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 482957007955 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957007956 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 482957007957 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 482957007958 Predicted membrane protein [Function unknown]; Region: COG4655 482957007959 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 482957007960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957007961 Walker A motif; other site 482957007962 ATP binding site [chemical binding]; other site 482957007963 Walker B motif; other site 482957007964 arginine finger; other site 482957007965 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957007966 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 482957007967 bacterial Hfq-like; Region: Hfq; cd01716 482957007968 hexamer interface [polypeptide binding]; other site 482957007969 Sm1 motif; other site 482957007970 RNA binding site [nucleotide binding]; other site 482957007971 Sm2 motif; other site 482957007972 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 482957007973 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 482957007974 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 482957007975 acyl-activating enzyme (AAE) consensus motif; other site 482957007976 putative AMP binding site [chemical binding]; other site 482957007977 putative active site [active] 482957007978 putative CoA binding site [chemical binding]; other site 482957007979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957007980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957007981 putative sialic acid transporter; Region: 2A0112; TIGR00891 482957007982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957007983 putative substrate translocation pore; other site 482957007984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957007985 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957007986 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 482957007987 high affinity sulphate transporter 1; Region: sulP; TIGR00815 482957007988 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 482957007989 Sulfate transporter family; Region: Sulfate_transp; pfam00916 482957007990 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 482957007991 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957007992 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 482957007993 putative substrate binding site [chemical binding]; other site 482957007994 putative ATP binding site [chemical binding]; other site 482957007995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 482957007996 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 482957007997 putative ligand binding site [chemical binding]; other site 482957007998 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957007999 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957008000 TM-ABC transporter signature motif; other site 482957008001 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 482957008002 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957008003 Walker A/P-loop; other site 482957008004 ATP binding site [chemical binding]; other site 482957008005 Q-loop/lid; other site 482957008006 ABC transporter signature motif; other site 482957008007 Walker B; other site 482957008008 D-loop; other site 482957008009 H-loop/switch region; other site 482957008010 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957008011 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 482957008012 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 482957008013 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 482957008014 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957008015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957008016 substrate binding pocket [chemical binding]; other site 482957008017 membrane-bound complex binding site; other site 482957008018 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957008019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008020 putative substrate translocation pore; other site 482957008021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008022 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957008023 MarR family; Region: MarR_2; cl17246 482957008024 ribonuclease R; Region: RNase_R; TIGR02063 482957008025 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 482957008026 RNB domain; Region: RNB; pfam00773 482957008027 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 482957008028 RNA binding site [nucleotide binding]; other site 482957008029 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 482957008030 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 482957008031 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 482957008032 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 482957008033 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 482957008034 amidase catalytic site [active] 482957008035 Zn binding residues [ion binding]; other site 482957008036 substrate binding site [chemical binding]; other site 482957008037 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 482957008038 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 482957008039 tetramer (dimer of dimers) interface [polypeptide binding]; other site 482957008040 active site 482957008041 dimer interface [polypeptide binding]; other site 482957008042 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957008043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957008044 DNA-binding site [nucleotide binding]; DNA binding site 482957008045 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957008046 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 482957008047 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 482957008048 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957008049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008050 dimer interface [polypeptide binding]; other site 482957008051 conserved gate region; other site 482957008052 putative PBP binding loops; other site 482957008053 ABC-ATPase subunit interface; other site 482957008054 cystine transporter subunit; Provisional; Region: PRK11260 482957008055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957008056 substrate binding pocket [chemical binding]; other site 482957008057 membrane-bound complex binding site; other site 482957008058 hinge residues; other site 482957008059 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 482957008060 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 482957008061 quinone interaction residues [chemical binding]; other site 482957008062 active site 482957008063 catalytic residues [active] 482957008064 FMN binding site [chemical binding]; other site 482957008065 substrate binding site [chemical binding]; other site 482957008066 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 482957008067 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 482957008068 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 482957008069 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 482957008070 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 482957008071 nudix motif; other site 482957008072 hypothetical protein; Provisional; Region: PRK02487 482957008073 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 482957008074 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 482957008075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957008076 substrate binding site [chemical binding]; other site 482957008077 oxyanion hole (OAH) forming residues; other site 482957008078 trimer interface [polypeptide binding]; other site 482957008079 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 482957008080 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 482957008081 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 482957008082 active site 482957008083 dimer interface [polypeptide binding]; other site 482957008084 non-prolyl cis peptide bond; other site 482957008085 insertion regions; other site 482957008086 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957008087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008088 dimer interface [polypeptide binding]; other site 482957008089 conserved gate region; other site 482957008090 putative PBP binding loops; other site 482957008091 ABC-ATPase subunit interface; other site 482957008092 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 482957008093 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957008094 Walker A/P-loop; other site 482957008095 ATP binding site [chemical binding]; other site 482957008096 Q-loop/lid; other site 482957008097 ABC transporter signature motif; other site 482957008098 Walker B; other site 482957008099 D-loop; other site 482957008100 H-loop/switch region; other site 482957008101 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 482957008102 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 482957008103 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 482957008104 FMN binding site [chemical binding]; other site 482957008105 active site 482957008106 catalytic residues [active] 482957008107 substrate binding site [chemical binding]; other site 482957008108 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 482957008109 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957008110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957008111 Coenzyme A binding pocket [chemical binding]; other site 482957008112 Family of unknown function (DUF695); Region: DUF695; pfam05117 482957008113 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 482957008114 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 482957008115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957008116 active site 482957008117 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 482957008118 putative dimer interface [polypeptide binding]; other site 482957008119 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957008120 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 482957008121 GAF domain; Region: GAF; pfam01590 482957008122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957008123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957008124 metal binding site [ion binding]; metal-binding site 482957008125 active site 482957008126 I-site; other site 482957008127 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 482957008128 PLD-like domain; Region: PLDc_2; pfam13091 482957008129 putative active site [active] 482957008130 catalytic site [active] 482957008131 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957008132 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 482957008133 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 482957008134 CoenzymeA binding site [chemical binding]; other site 482957008135 subunit interaction site [polypeptide binding]; other site 482957008136 PHB binding site; other site 482957008137 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957008138 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957008139 active site 482957008140 catalytic tetrad [active] 482957008141 citrate-proton symporter; Provisional; Region: PRK15075 482957008142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008143 putative substrate translocation pore; other site 482957008144 hypothetical protein; Provisional; Region: PRK07079 482957008145 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 482957008146 metal binding site [ion binding]; metal-binding site 482957008147 putative dimer interface [polypeptide binding]; other site 482957008148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957008151 dimerization interface [polypeptide binding]; other site 482957008152 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 482957008153 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 482957008154 active site residue [active] 482957008155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957008156 Walker A/P-loop; other site 482957008157 ATP binding site [chemical binding]; other site 482957008158 Q-loop/lid; other site 482957008159 ABC transporter signature motif; other site 482957008160 Predicted permease; Region: DUF318; cl17795 482957008161 ABC-2 type transporter; Region: ABC2_membrane; cl17235 482957008162 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 482957008163 nodulation ABC transporter NodI; Provisional; Region: PRK13537 482957008164 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 482957008165 Walker A/P-loop; other site 482957008166 ATP binding site [chemical binding]; other site 482957008167 Q-loop/lid; other site 482957008168 ABC transporter signature motif; other site 482957008169 Walker B; other site 482957008170 D-loop; other site 482957008171 H-loop/switch region; other site 482957008172 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957008173 Ligand Binding Site [chemical binding]; other site 482957008174 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 482957008175 LexA repressor; Validated; Region: PRK00215 482957008176 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 482957008177 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 482957008178 Catalytic site [active] 482957008179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957008180 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 482957008181 substrate binding pocket [chemical binding]; other site 482957008182 membrane-bound complex binding site; other site 482957008183 hinge residues; other site 482957008184 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 482957008185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008186 dimer interface [polypeptide binding]; other site 482957008187 conserved gate region; other site 482957008188 putative PBP binding loops; other site 482957008189 ABC-ATPase subunit interface; other site 482957008190 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 482957008191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008192 dimer interface [polypeptide binding]; other site 482957008193 conserved gate region; other site 482957008194 putative PBP binding loops; other site 482957008195 ABC-ATPase subunit interface; other site 482957008196 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 482957008197 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 482957008198 Walker A/P-loop; other site 482957008199 ATP binding site [chemical binding]; other site 482957008200 Q-loop/lid; other site 482957008201 ABC transporter signature motif; other site 482957008202 Walker B; other site 482957008203 D-loop; other site 482957008204 H-loop/switch region; other site 482957008205 TOBE-like domain; Region: TOBE_3; pfam12857 482957008206 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 482957008207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008208 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 482957008209 substrate binding site [chemical binding]; other site 482957008210 dimerization interface [polypeptide binding]; other site 482957008211 Protein of unknown function (DUF805); Region: DUF805; pfam05656 482957008212 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 482957008213 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 482957008214 ligand binding site [chemical binding]; other site 482957008215 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 482957008216 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957008217 Walker A/P-loop; other site 482957008218 ATP binding site [chemical binding]; other site 482957008219 Q-loop/lid; other site 482957008220 ABC transporter signature motif; other site 482957008221 Walker B; other site 482957008222 D-loop; other site 482957008223 H-loop/switch region; other site 482957008224 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957008225 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957008226 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957008227 TM-ABC transporter signature motif; other site 482957008228 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957008229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957008230 DNA binding site [nucleotide binding] 482957008231 domain linker motif; other site 482957008232 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 482957008233 dimerization interface [polypeptide binding]; other site 482957008234 ligand binding site [chemical binding]; other site 482957008235 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957008236 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 482957008237 substrate binding site [chemical binding]; other site 482957008238 dimer interface [polypeptide binding]; other site 482957008239 ATP binding site [chemical binding]; other site 482957008240 Tar ligand binding domain homologue; Region: TarH; pfam02203 482957008241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957008242 dimer interface [polypeptide binding]; other site 482957008243 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 482957008244 putative CheW interface [polypeptide binding]; other site 482957008245 PrkA family serine protein kinase; Provisional; Region: PRK15455 482957008246 AAA ATPase domain; Region: AAA_16; pfam13191 482957008247 Walker A motif; other site 482957008248 ATP binding site [chemical binding]; other site 482957008249 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 482957008250 hypothetical protein; Provisional; Region: PRK05325 482957008251 SpoVR family protein; Provisional; Region: PRK11767 482957008252 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 482957008253 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 482957008254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008255 putative substrate translocation pore; other site 482957008256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008258 LysR substrate binding domain; Region: LysR_substrate; pfam03466 482957008259 dimerization interface [polypeptide binding]; other site 482957008260 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 482957008261 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 482957008262 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 482957008263 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 482957008264 putative active site; other site 482957008265 catalytic triad [active] 482957008266 putative dimer interface [polypeptide binding]; other site 482957008267 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 482957008268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957008269 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 482957008270 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 482957008271 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 482957008272 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 482957008273 Serine hydrolase; Region: Ser_hydrolase; cl17834 482957008274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957008275 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957008276 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957008277 substrate binding pocket [chemical binding]; other site 482957008278 membrane-bound complex binding site; other site 482957008279 hinge residues; other site 482957008280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008281 dimer interface [polypeptide binding]; other site 482957008282 conserved gate region; other site 482957008283 putative PBP binding loops; other site 482957008284 ABC-ATPase subunit interface; other site 482957008285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008286 dimer interface [polypeptide binding]; other site 482957008287 conserved gate region; other site 482957008288 putative PBP binding loops; other site 482957008289 ABC-ATPase subunit interface; other site 482957008290 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 482957008291 Peptidase family M23; Region: Peptidase_M23; pfam01551 482957008292 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 482957008293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957008294 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 482957008295 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957008296 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957008297 multidrug efflux protein; Reviewed; Region: PRK09577 482957008298 Protein export membrane protein; Region: SecD_SecF; cl14618 482957008299 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957008300 Fimbrial protein; Region: Fimbrial; cl01416 482957008301 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 482957008302 PapC N-terminal domain; Region: PapC_N; pfam13954 482957008303 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 482957008304 PapC C-terminal domain; Region: PapC_C; pfam13953 482957008305 putativi pili assembly chaperone; Provisional; Region: PRK11385 482957008306 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 482957008307 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 482957008308 Fimbrial protein; Region: Fimbrial; pfam00419 482957008309 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 482957008310 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 482957008311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957008312 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 482957008313 MbtH-like protein; Region: MbtH; cl01279 482957008314 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 482957008315 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 482957008316 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 482957008317 Walker A/P-loop; other site 482957008318 ATP binding site [chemical binding]; other site 482957008319 Q-loop/lid; other site 482957008320 ABC transporter signature motif; other site 482957008321 Walker B; other site 482957008322 D-loop; other site 482957008323 H-loop/switch region; other site 482957008324 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 482957008325 FecCD transport family; Region: FecCD; pfam01032 482957008326 dimer interface [polypeptide binding]; other site 482957008327 putative PBP binding regions; other site 482957008328 ABC-ATPase subunit interface; other site 482957008329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 482957008330 ABC-ATPase subunit interface; other site 482957008331 dimer interface [polypeptide binding]; other site 482957008332 putative PBP binding regions; other site 482957008333 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 482957008334 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 482957008335 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 482957008336 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 482957008337 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 482957008338 siderophore binding site; other site 482957008339 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 482957008340 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 482957008341 Walker A/P-loop; other site 482957008342 ATP binding site [chemical binding]; other site 482957008343 Q-loop/lid; other site 482957008344 ABC transporter signature motif; other site 482957008345 Walker B; other site 482957008346 D-loop; other site 482957008347 H-loop/switch region; other site 482957008348 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 482957008349 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 482957008350 acyl-activating enzyme (AAE) consensus motif; other site 482957008351 AMP binding site [chemical binding]; other site 482957008352 Condensation domain; Region: Condensation; pfam00668 482957008353 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 482957008354 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 482957008355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957008356 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 482957008357 acyl-activating enzyme (AAE) consensus motif; other site 482957008358 AMP binding site [chemical binding]; other site 482957008359 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 482957008360 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 482957008361 Condensation domain; Region: Condensation; pfam00668 482957008362 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 482957008363 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 482957008364 acyl-activating enzyme (AAE) consensus motif; other site 482957008365 AMP binding site [chemical binding]; other site 482957008366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 482957008367 Condensation domain; Region: Condensation; pfam00668 482957008368 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 482957008369 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 482957008370 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 482957008371 acyl-activating enzyme (AAE) consensus motif; other site 482957008372 AMP binding site [chemical binding]; other site 482957008373 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 482957008374 Condensation domain; Region: Condensation; pfam00668 482957008375 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 482957008376 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 482957008377 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 482957008378 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 482957008379 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 482957008380 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957008381 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 482957008382 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957008383 N-terminal plug; other site 482957008384 ligand-binding site [chemical binding]; other site 482957008385 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 482957008386 catalytic site [active] 482957008387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 482957008388 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 482957008389 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 482957008390 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 482957008391 oligomeric interface; other site 482957008392 putative active site [active] 482957008393 homodimer interface [polypeptide binding]; other site 482957008394 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 482957008395 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 482957008396 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957008397 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957008398 metal binding site [ion binding]; metal-binding site 482957008399 putative dimer interface [polypeptide binding]; other site 482957008400 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 482957008401 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 482957008402 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 482957008403 catalytic triad [active] 482957008404 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 482957008405 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 482957008406 homodimer interface [polypeptide binding]; other site 482957008407 Walker A motif; other site 482957008408 ATP binding site [chemical binding]; other site 482957008409 hydroxycobalamin binding site [chemical binding]; other site 482957008410 Walker B motif; other site 482957008411 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 482957008412 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 482957008413 active site 482957008414 SAM binding site [chemical binding]; other site 482957008415 homodimer interface [polypeptide binding]; other site 482957008416 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 482957008417 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 482957008418 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 482957008419 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 482957008420 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 482957008421 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 482957008422 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 482957008423 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 482957008424 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 482957008425 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 482957008426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957008427 Walker A motif; other site 482957008428 ATP binding site [chemical binding]; other site 482957008429 Walker B motif; other site 482957008430 arginine finger; other site 482957008431 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 482957008432 metal ion-dependent adhesion site (MIDAS); other site 482957008433 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 482957008434 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 482957008435 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 482957008436 active site 482957008437 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 482957008438 nudix motif; other site 482957008439 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957008440 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957008441 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 482957008442 Citrate transporter; Region: CitMHS; pfam03600 482957008443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957008444 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957008445 active site 482957008446 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957008447 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 482957008448 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957008449 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 482957008450 active site 482957008451 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 482957008452 aromatic chitin/cellulose binding site residues [chemical binding]; other site 482957008453 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 482957008454 aromatic chitin/cellulose binding site residues [chemical binding]; other site 482957008455 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 482957008456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008457 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957008458 dimerization interface [polypeptide binding]; other site 482957008459 substrate binding pocket [chemical binding]; other site 482957008460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008461 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957008462 putative substrate translocation pore; other site 482957008463 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 482957008464 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 482957008465 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 482957008466 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 482957008467 active site 482957008468 SAM binding site [chemical binding]; other site 482957008469 homodimer interface [polypeptide binding]; other site 482957008470 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 482957008471 active site 482957008472 SAM binding site [chemical binding]; other site 482957008473 homodimer interface [polypeptide binding]; other site 482957008474 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 482957008475 Precorrin-8X methylmutase; Region: CbiC; pfam02570 482957008476 precorrin-3B synthase; Region: CobG; TIGR02435 482957008477 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 482957008478 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 482957008479 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 482957008480 active site 482957008481 putative homodimer interface [polypeptide binding]; other site 482957008482 SAM binding site [chemical binding]; other site 482957008483 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 482957008484 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 482957008485 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 482957008486 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 482957008487 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 482957008488 active site 482957008489 SAM binding site [chemical binding]; other site 482957008490 homodimer interface [polypeptide binding]; other site 482957008491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957008492 MarR family; Region: MarR_2; pfam12802 482957008493 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 482957008494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 482957008495 putative substrate translocation pore; other site 482957008496 MarR family; Region: MarR_2; cl17246 482957008497 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957008498 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957008499 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 482957008500 C-terminal domain interface [polypeptide binding]; other site 482957008501 GSH binding site (G-site) [chemical binding]; other site 482957008502 dimer interface [polypeptide binding]; other site 482957008503 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 482957008504 dimer interface [polypeptide binding]; other site 482957008505 N-terminal domain interface [polypeptide binding]; other site 482957008506 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957008507 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957008508 trimer interface [polypeptide binding]; other site 482957008509 eyelet of channel; other site 482957008510 AAA domain; Region: AAA_22; pfam13401 482957008511 AAA ATPase domain; Region: AAA_16; pfam13191 482957008512 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957008513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957008514 DNA binding residues [nucleotide binding] 482957008515 dimerization interface [polypeptide binding]; other site 482957008516 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 482957008517 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 482957008518 NADP binding site [chemical binding]; other site 482957008519 dimer interface [polypeptide binding]; other site 482957008520 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 482957008521 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 482957008522 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 482957008523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008524 putative substrate translocation pore; other site 482957008525 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 482957008526 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957008527 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 482957008528 hypothetical protein; Provisional; Region: PRK11622 482957008529 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 482957008530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957008531 Walker A/P-loop; other site 482957008532 ATP binding site [chemical binding]; other site 482957008533 Q-loop/lid; other site 482957008534 ABC transporter signature motif; other site 482957008535 Walker B; other site 482957008536 D-loop; other site 482957008537 H-loop/switch region; other site 482957008538 TOBE domain; Region: TOBE_2; pfam08402 482957008539 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 482957008540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008541 dimer interface [polypeptide binding]; other site 482957008542 conserved gate region; other site 482957008543 putative PBP binding loops; other site 482957008544 ABC-ATPase subunit interface; other site 482957008545 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957008546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008547 dimer interface [polypeptide binding]; other site 482957008548 conserved gate region; other site 482957008549 putative PBP binding loops; other site 482957008550 ABC-ATPase subunit interface; other site 482957008551 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 482957008552 glycerate dehydrogenase; Provisional; Region: PRK06932 482957008553 putative ligand binding site [chemical binding]; other site 482957008554 putative NAD binding site [chemical binding]; other site 482957008555 catalytic site [active] 482957008556 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957008557 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957008558 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 482957008559 active site 482957008560 catalytic residues [active] 482957008561 metal binding site [ion binding]; metal-binding site 482957008562 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 482957008563 dimer interface [polypeptide binding]; other site 482957008564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957008565 metal binding site [ion binding]; metal-binding site 482957008566 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957008567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008569 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 482957008570 putative dimerization interface [polypeptide binding]; other site 482957008571 Cupin domain; Region: Cupin_2; cl17218 482957008572 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 482957008573 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957008574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957008575 S-adenosylmethionine binding site [chemical binding]; other site 482957008576 benzoate transport; Region: 2A0115; TIGR00895 482957008577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008578 putative substrate translocation pore; other site 482957008579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008580 putative substrate translocation pore; other site 482957008581 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 482957008582 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 482957008583 hypothetical protein; Reviewed; Region: PRK09588 482957008584 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 482957008585 RNA ligase; Region: RNA_ligase; pfam09414 482957008586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 482957008587 Zn2+ binding site [ion binding]; other site 482957008588 Mg2+ binding site [ion binding]; other site 482957008589 AAA domain; Region: AAA_33; pfam13671 482957008590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008592 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 482957008593 putative effector binding pocket; other site 482957008594 putative dimerization interface [polypeptide binding]; other site 482957008595 drug efflux system protein MdtG; Provisional; Region: PRK09874 482957008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008597 putative substrate translocation pore; other site 482957008598 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 482957008599 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957008600 FMN binding site [chemical binding]; other site 482957008601 substrate binding site [chemical binding]; other site 482957008602 putative catalytic residue [active] 482957008603 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 482957008604 Uncharacterized conserved protein [Function unknown]; Region: COG3791 482957008605 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957008606 MarR family; Region: MarR; pfam01047 482957008607 Predicted acetyltransferase [General function prediction only]; Region: COG3393 482957008608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957008609 Coenzyme A binding pocket [chemical binding]; other site 482957008610 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 482957008611 HAMP domain; Region: HAMP; pfam00672 482957008612 dimerization interface [polypeptide binding]; other site 482957008613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957008614 dimer interface [polypeptide binding]; other site 482957008615 phosphorylation site [posttranslational modification] 482957008616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957008617 ATP binding site [chemical binding]; other site 482957008618 Mg2+ binding site [ion binding]; other site 482957008619 G-X-G motif; other site 482957008620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957008621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957008622 active site 482957008623 phosphorylation site [posttranslational modification] 482957008624 intermolecular recognition site; other site 482957008625 dimerization interface [polypeptide binding]; other site 482957008626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957008627 DNA binding site [nucleotide binding] 482957008628 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 482957008629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957008630 S-adenosylmethionine binding site [chemical binding]; other site 482957008631 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957008632 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957008633 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 482957008634 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 482957008635 homotrimer interaction site [polypeptide binding]; other site 482957008636 putative active site [active] 482957008637 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008639 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957008640 putative effector binding pocket; other site 482957008641 dimerization interface [polypeptide binding]; other site 482957008642 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957008643 classical (c) SDRs; Region: SDR_c; cd05233 482957008644 NAD(P) binding site [chemical binding]; other site 482957008645 active site 482957008646 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957008647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957008648 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 482957008649 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 482957008650 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957008651 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957008652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008653 putative substrate translocation pore; other site 482957008654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 482957008655 hypothetical protein; Provisional; Region: PRK07236 482957008656 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 482957008657 Predicted transcriptional regulators [Transcription]; Region: COG1695 482957008658 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957008659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957008660 S-adenosylmethionine binding site [chemical binding]; other site 482957008661 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 482957008662 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 482957008663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957008664 NAD(P) binding site [chemical binding]; other site 482957008665 active site 482957008666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957008667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957008668 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 482957008669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957008670 Zn binding site [ion binding]; other site 482957008671 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 482957008672 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957008673 acyl-activating enzyme (AAE) consensus motif; other site 482957008674 AMP binding site [chemical binding]; other site 482957008675 active site 482957008676 CoA binding site [chemical binding]; other site 482957008677 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 482957008678 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 482957008679 active site 482957008680 hypothetical protein; Provisional; Region: PRK07236 482957008681 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957008682 benzoate transport; Region: 2A0115; TIGR00895 482957008683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008684 putative substrate translocation pore; other site 482957008685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008686 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957008687 putative substrate translocation pore; other site 482957008688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008690 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 482957008691 putative effector binding pocket; other site 482957008692 putative dimerization interface [polypeptide binding]; other site 482957008693 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 482957008694 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957008695 classical (c) SDRs; Region: SDR_c; cd05233 482957008696 NAD(P) binding site [chemical binding]; other site 482957008697 active site 482957008698 Amidohydrolase; Region: Amidohydro_2; pfam04909 482957008699 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 482957008700 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957008701 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 482957008702 NAD(P) binding site [chemical binding]; other site 482957008703 catalytic residues [active] 482957008704 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 482957008705 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957008706 LysR family transcriptional regulator; Provisional; Region: PRK14997 482957008707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008708 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957008709 putative effector binding pocket; other site 482957008710 dimerization interface [polypeptide binding]; other site 482957008711 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 482957008712 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 482957008713 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957008714 active site 482957008715 HIGH motif; other site 482957008716 nucleotide binding site [chemical binding]; other site 482957008717 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 482957008718 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 482957008719 DNA binding site [nucleotide binding] 482957008720 active site 482957008721 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 482957008722 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 482957008723 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 482957008724 putative active site pocket [active] 482957008725 dimerization interface [polypeptide binding]; other site 482957008726 putative catalytic residue [active] 482957008727 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 482957008728 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 482957008729 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 482957008730 DNA binding site [nucleotide binding] 482957008731 active site 482957008732 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 482957008733 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 482957008734 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 482957008735 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 482957008736 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 482957008737 DNA binding site [nucleotide binding] 482957008738 active site 482957008739 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 482957008740 endonuclease III; Region: ENDO3c; smart00478 482957008741 minor groove reading motif; other site 482957008742 helix-hairpin-helix signature motif; other site 482957008743 substrate binding pocket [chemical binding]; other site 482957008744 active site 482957008745 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 482957008746 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 482957008747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957008748 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 482957008749 DNA binding site [nucleotide binding] 482957008750 active site 482957008751 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 482957008752 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 482957008753 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 482957008754 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 482957008755 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957008756 active site 482957008757 nucleotide binding site [chemical binding]; other site 482957008758 HIGH motif; other site 482957008759 KMSKS motif; other site 482957008760 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 482957008761 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 482957008762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957008763 ABC transporter signature motif; other site 482957008764 Walker B; other site 482957008765 D-loop; other site 482957008766 H-loop/switch region; other site 482957008767 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957008768 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957008769 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957008770 active site 482957008771 catalytic tetrad [active] 482957008772 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 482957008773 KTSC domain; Region: KTSC; pfam13619 482957008774 hypothetical protein; Provisional; Region: PRK07236 482957008775 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 482957008776 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 482957008777 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 482957008778 catalytic residues [active] 482957008779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008781 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957008782 putative effector binding pocket; other site 482957008783 dimerization interface [polypeptide binding]; other site 482957008784 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957008785 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957008786 trimer interface [polypeptide binding]; other site 482957008787 eyelet of channel; other site 482957008788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957008789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957008790 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 482957008791 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957008792 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 482957008793 FMN binding site [chemical binding]; other site 482957008794 active site 482957008795 substrate binding site [chemical binding]; other site 482957008796 catalytic residue [active] 482957008797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008798 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957008799 putative substrate translocation pore; other site 482957008800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957008801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008802 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957008803 putative effector binding pocket; other site 482957008804 putative dimerization interface [polypeptide binding]; other site 482957008805 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957008806 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957008807 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 482957008808 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957008809 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957008810 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 482957008811 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957008812 catalytic loop [active] 482957008813 iron binding site [ion binding]; other site 482957008814 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957008815 Cytochrome c; Region: Cytochrom_C; pfam00034 482957008816 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957008817 Cytochrome c; Region: Cytochrom_C; pfam00034 482957008818 Cytochrome c; Region: Cytochrom_C; pfam00034 482957008819 hypothetical protein; Provisional; Region: PRK07236 482957008820 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 482957008821 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 482957008822 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 482957008823 Na binding site [ion binding]; other site 482957008824 Protein of unknown function, DUF485; Region: DUF485; pfam04341 482957008825 hypothetical protein; Provisional; Region: PRK07236 482957008826 FAD binding domain; Region: FAD_binding_3; pfam01494 482957008827 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957008828 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 482957008829 dimer interface [polypeptide binding]; other site 482957008830 putative metal binding site [ion binding]; other site 482957008831 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 482957008832 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 482957008833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957008834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957008835 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957008836 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 482957008837 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957008838 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957008839 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957008840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008841 putative substrate translocation pore; other site 482957008842 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957008843 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957008844 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957008845 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 482957008846 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 482957008847 Zn2+ binding site [ion binding]; other site 482957008848 Mg2+ binding site [ion binding]; other site 482957008849 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957008850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957008851 DNA binding site [nucleotide binding] 482957008852 Predicted ATPase [General function prediction only]; Region: COG3903 482957008853 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 482957008854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957008855 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957008856 dimerization interface [polypeptide binding]; other site 482957008857 Transposase; Region: HTH_Tnp_1; pfam01527 482957008858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 482957008859 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 482957008860 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 482957008861 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 482957008862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 482957008863 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 482957008864 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 482957008865 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 482957008866 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 482957008867 putative hydrophobic ligand binding site [chemical binding]; other site 482957008868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957008869 dimerization interface [polypeptide binding]; other site 482957008870 putative DNA binding site [nucleotide binding]; other site 482957008871 putative Zn2+ binding site [ion binding]; other site 482957008872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957008873 non-specific DNA binding site [nucleotide binding]; other site 482957008874 salt bridge; other site 482957008875 sequence-specific DNA binding site [nucleotide binding]; other site 482957008876 Phage integrase protein; Region: DUF3701; pfam12482 482957008877 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 482957008878 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957008879 active site 482957008880 DNA binding site [nucleotide binding] 482957008881 Int/Topo IB signature motif; other site 482957008882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 482957008883 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 482957008884 active site 482957008885 catalytic residues [active] 482957008886 DNA binding site [nucleotide binding] 482957008887 Int/Topo IB signature motif; other site 482957008888 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 482957008889 active site 482957008890 catalytic residues [active] 482957008891 DNA binding site [nucleotide binding] 482957008892 Int/Topo IB signature motif; other site 482957008893 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 482957008894 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957008895 C-terminal domain interface [polypeptide binding]; other site 482957008896 GSH binding site (G-site) [chemical binding]; other site 482957008897 dimer interface [polypeptide binding]; other site 482957008898 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 482957008899 dimer interface [polypeptide binding]; other site 482957008900 N-terminal domain interface [polypeptide binding]; other site 482957008901 substrate binding pocket (H-site) [chemical binding]; other site 482957008902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957008903 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 482957008904 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 482957008905 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 482957008906 active site 482957008907 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 482957008908 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957008909 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 482957008910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957008911 catalytic residue [active] 482957008912 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 482957008913 Protein export membrane protein; Region: SecD_SecF; cl14618 482957008914 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 482957008915 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 482957008916 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 482957008917 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957008918 Walker A/P-loop; other site 482957008919 ATP binding site [chemical binding]; other site 482957008920 Q-loop/lid; other site 482957008921 ABC transporter signature motif; other site 482957008922 Walker B; other site 482957008923 D-loop; other site 482957008924 H-loop/switch region; other site 482957008925 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957008926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957008927 Walker A/P-loop; other site 482957008928 ATP binding site [chemical binding]; other site 482957008929 Q-loop/lid; other site 482957008930 ABC transporter signature motif; other site 482957008931 Walker B; other site 482957008932 D-loop; other site 482957008933 H-loop/switch region; other site 482957008934 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957008935 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 482957008936 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 482957008937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008938 dimer interface [polypeptide binding]; other site 482957008939 conserved gate region; other site 482957008940 putative PBP binding loops; other site 482957008941 ABC-ATPase subunit interface; other site 482957008942 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 482957008943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957008944 dimer interface [polypeptide binding]; other site 482957008945 conserved gate region; other site 482957008946 putative PBP binding loops; other site 482957008947 ABC-ATPase subunit interface; other site 482957008948 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 482957008949 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 482957008950 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 482957008951 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 482957008952 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 482957008953 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 482957008954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957008955 non-specific DNA binding site [nucleotide binding]; other site 482957008956 salt bridge; other site 482957008957 sequence-specific DNA binding site [nucleotide binding]; other site 482957008958 Cupin domain; Region: Cupin_2; pfam07883 482957008959 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957008960 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957008961 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957008962 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957008963 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 482957008964 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 482957008965 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 482957008966 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 482957008967 putative deacylase active site [active] 482957008968 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 482957008969 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 482957008970 dimer interface [polypeptide binding]; other site 482957008971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957008972 catalytic residue [active] 482957008973 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 482957008974 YciI-like protein; Reviewed; Region: PRK12866 482957008975 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 482957008976 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 482957008977 oligomer interface [polypeptide binding]; other site 482957008978 metal binding site [ion binding]; metal-binding site 482957008979 metal binding site [ion binding]; metal-binding site 482957008980 putative Cl binding site [ion binding]; other site 482957008981 basic sphincter; other site 482957008982 hydrophobic gate; other site 482957008983 periplasmic entrance; other site 482957008984 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 482957008985 AAA domain; Region: AAA_33; pfam13671 482957008986 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 482957008987 active site 482957008988 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 482957008989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957008990 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 482957008991 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 482957008992 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 482957008993 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 482957008994 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 482957008995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957008996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957008997 active site 482957008998 phosphorylation site [posttranslational modification] 482957008999 intermolecular recognition site; other site 482957009000 dimerization interface [polypeptide binding]; other site 482957009001 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957009002 DNA binding site [nucleotide binding] 482957009003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957009004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957009005 dimer interface [polypeptide binding]; other site 482957009006 phosphorylation site [posttranslational modification] 482957009007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957009008 ATP binding site [chemical binding]; other site 482957009009 Mg2+ binding site [ion binding]; other site 482957009010 G-X-G motif; other site 482957009011 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957009012 AsnC family; Region: AsnC_trans_reg; pfam01037 482957009013 LTXXQ motif family protein; Region: LTXXQ; pfam07813 482957009014 PGDYG protein; Region: PGDYG; pfam14083 482957009015 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 482957009016 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 482957009017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957009018 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957009019 DNA binding site [nucleotide binding] 482957009020 domain linker motif; other site 482957009021 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 482957009022 putative ligand binding site [chemical binding]; other site 482957009023 putative dimerization interface [polypeptide binding]; other site 482957009024 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 482957009025 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 482957009026 dimerization interface [polypeptide binding]; other site 482957009027 ligand binding site [chemical binding]; other site 482957009028 NADP binding site [chemical binding]; other site 482957009029 catalytic site [active] 482957009030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957009031 D-galactonate transporter; Region: 2A0114; TIGR00893 482957009032 putative substrate translocation pore; other site 482957009033 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957009034 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 482957009035 substrate binding site [chemical binding]; other site 482957009036 ATP binding site [chemical binding]; other site 482957009037 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 482957009038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957009039 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 482957009040 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 482957009041 putative dimerization interface [polypeptide binding]; other site 482957009042 Predicted membrane protein [Function unknown]; Region: COG2855 482957009043 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 482957009044 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 482957009045 Cl- selectivity filter; other site 482957009046 Cl- binding residues [ion binding]; other site 482957009047 pore gating glutamate residue; other site 482957009048 dimer interface [polypeptide binding]; other site 482957009049 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 482957009050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957009051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957009052 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 482957009053 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957009054 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 482957009055 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957009056 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 482957009057 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 482957009058 DNA binding residues [nucleotide binding] 482957009059 putative dimer interface [polypeptide binding]; other site 482957009060 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 482957009061 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 482957009062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957009063 sequence-specific DNA binding site [nucleotide binding]; other site 482957009064 salt bridge; other site 482957009065 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 482957009066 PAS fold; Region: PAS_4; pfam08448 482957009067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957009068 putative active site [active] 482957009069 heme pocket [chemical binding]; other site 482957009070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957009071 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 482957009072 Walker A motif; other site 482957009073 ATP binding site [chemical binding]; other site 482957009074 Walker B motif; other site 482957009075 arginine finger; other site 482957009076 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 482957009077 Putative phosphatase (DUF442); Region: DUF442; cl17385 482957009078 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 482957009079 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957009080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957009081 dimer interface [polypeptide binding]; other site 482957009082 conserved gate region; other site 482957009083 putative PBP binding loops; other site 482957009084 ABC-ATPase subunit interface; other site 482957009085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957009086 dimer interface [polypeptide binding]; other site 482957009087 conserved gate region; other site 482957009088 putative PBP binding loops; other site 482957009089 ABC-ATPase subunit interface; other site 482957009090 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 482957009091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957009092 Walker A/P-loop; other site 482957009093 ATP binding site [chemical binding]; other site 482957009094 Q-loop/lid; other site 482957009095 ABC transporter signature motif; other site 482957009096 Walker B; other site 482957009097 D-loop; other site 482957009098 H-loop/switch region; other site 482957009099 TOBE domain; Region: TOBE_2; pfam08402 482957009100 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 482957009101 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957009102 Predicted Fe-S protein [General function prediction only]; Region: COG3313 482957009103 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 482957009104 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 482957009105 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957009106 FMN binding site [chemical binding]; other site 482957009107 substrate binding site [chemical binding]; other site 482957009108 putative catalytic residue [active] 482957009109 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 482957009110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957009111 NAD binding site [chemical binding]; other site 482957009112 catalytic residues [active] 482957009113 hypothetical protein; Provisional; Region: PRK11667 482957009114 AIPR protein; Region: AIPR; pfam10592 482957009115 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 482957009116 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 482957009117 NodB motif; other site 482957009118 active site 482957009119 catalytic site [active] 482957009120 metal binding site [ion binding]; metal-binding site 482957009121 Phosphotransferase enzyme family; Region: APH; pfam01636 482957009122 active site 482957009123 ATP binding site [chemical binding]; other site 482957009124 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 482957009125 substrate binding site [chemical binding]; other site 482957009126 Cephalosporin hydroxylase; Region: CmcI; pfam04989 482957009127 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 482957009128 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 482957009129 active site 482957009130 TDP-binding site; other site 482957009131 acceptor substrate-binding pocket; other site 482957009132 homodimer interface [polypeptide binding]; other site 482957009133 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 482957009134 Asparagine synthase; Region: Asn_synthase; pfam00733 482957009135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957009136 FeS/SAM binding site; other site 482957009137 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 482957009138 substrate binding site [chemical binding]; other site 482957009139 Glutaredoxin-like domain (DUF836); Region: DUF836; cl17650 482957009140 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 482957009141 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957009142 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957009143 ABC transporter; Region: ABC_tran_2; pfam12848 482957009144 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957009145 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 482957009146 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 482957009147 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 482957009148 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 482957009149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 482957009150 Walker A/P-loop; other site 482957009151 ATP binding site [chemical binding]; other site 482957009152 Q-loop/lid; other site 482957009153 ABC transporter signature motif; other site 482957009154 Walker B; other site 482957009155 D-loop; other site 482957009156 H-loop/switch region; other site 482957009157 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 482957009158 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 482957009159 dimer interface [polypeptide binding]; other site 482957009160 putative inhibitory loop; other site 482957009161 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 482957009162 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 482957009163 putative NAD(P) binding site [chemical binding]; other site 482957009164 dimer interface [polypeptide binding]; other site 482957009165 transcriptional activator TtdR; Provisional; Region: PRK09801 482957009166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957009167 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957009168 putative effector binding pocket; other site 482957009169 dimerization interface [polypeptide binding]; other site 482957009170 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 482957009171 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 482957009172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957009173 motif II; other site 482957009174 cystathionine beta-lyase; Provisional; Region: PRK07050 482957009175 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957009176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957009177 catalytic residue [active] 482957009178 beta-ketothiolase; Provisional; Region: PRK09051 482957009179 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957009180 dimer interface [polypeptide binding]; other site 482957009181 active site 482957009182 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 482957009183 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957009184 substrate binding site [chemical binding]; other site 482957009185 ATP binding site [chemical binding]; other site 482957009186 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 482957009187 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 482957009188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957009189 FeS/SAM binding site; other site 482957009190 TRAM domain; Region: TRAM; cl01282 482957009191 RibD C-terminal domain; Region: RibD_C; cl17279 482957009192 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 482957009193 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 482957009194 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 482957009195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 482957009196 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 482957009197 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 482957009198 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 482957009199 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 482957009200 NAD(P) binding site [chemical binding]; other site 482957009201 homotetramer interface [polypeptide binding]; other site 482957009202 homodimer interface [polypeptide binding]; other site 482957009203 active site 482957009204 putative acyltransferase; Provisional; Region: PRK05790 482957009205 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957009206 dimer interface [polypeptide binding]; other site 482957009207 active site 482957009208 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 482957009209 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 482957009210 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 482957009211 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 482957009212 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 482957009213 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957009214 RNA binding surface [nucleotide binding]; other site 482957009215 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 482957009216 active site 482957009217 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 482957009218 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 482957009219 DEAD_2; Region: DEAD_2; pfam06733 482957009220 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 482957009221 Protein of unknown function (DUF465); Region: DUF465; pfam04325 482957009222 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 482957009223 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 482957009224 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 482957009225 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 482957009226 RNA binding site [nucleotide binding]; other site 482957009227 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 482957009228 potassium uptake protein; Region: kup; TIGR00794 482957009229 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 482957009230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957009231 active site 482957009232 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 482957009233 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 482957009234 GDP-binding site [chemical binding]; other site 482957009235 ACT binding site; other site 482957009236 IMP binding site; other site 482957009237 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 482957009238 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 482957009239 dimer interface [polypeptide binding]; other site 482957009240 motif 1; other site 482957009241 active site 482957009242 motif 2; other site 482957009243 motif 3; other site 482957009244 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 482957009245 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 482957009246 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 482957009247 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 482957009248 HflK protein; Region: hflK; TIGR01933 482957009249 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 482957009250 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 482957009251 HflX GTPase family; Region: HflX; cd01878 482957009252 G1 box; other site 482957009253 GTP/Mg2+ binding site [chemical binding]; other site 482957009254 Switch I region; other site 482957009255 G2 box; other site 482957009256 G3 box; other site 482957009257 Switch II region; other site 482957009258 G4 box; other site 482957009259 G5 box; other site 482957009260 bacterial Hfq-like; Region: Hfq; cd01716 482957009261 hexamer interface [polypeptide binding]; other site 482957009262 Sm1 motif; other site 482957009263 RNA binding site [nucleotide binding]; other site 482957009264 Sm2 motif; other site 482957009265 GTP-binding protein Der; Reviewed; Region: PRK00093 482957009266 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 482957009267 G1 box; other site 482957009268 GTP/Mg2+ binding site [chemical binding]; other site 482957009269 Switch I region; other site 482957009270 G2 box; other site 482957009271 Switch II region; other site 482957009272 G3 box; other site 482957009273 G4 box; other site 482957009274 G5 box; other site 482957009275 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 482957009276 G1 box; other site 482957009277 GTP/Mg2+ binding site [chemical binding]; other site 482957009278 Switch I region; other site 482957009279 G2 box; other site 482957009280 G3 box; other site 482957009281 Switch II region; other site 482957009282 G4 box; other site 482957009283 G5 box; other site 482957009284 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 482957009285 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 482957009286 Trp docking motif [polypeptide binding]; other site 482957009287 active site 482957009288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 482957009289 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 482957009290 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 482957009291 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 482957009292 dimer interface [polypeptide binding]; other site 482957009293 motif 1; other site 482957009294 active site 482957009295 motif 2; other site 482957009296 motif 3; other site 482957009297 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 482957009298 anticodon binding site; other site 482957009299 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 482957009300 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 482957009301 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 482957009302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957009303 non-specific DNA binding site [nucleotide binding]; other site 482957009304 salt bridge; other site 482957009305 sequence-specific DNA binding site [nucleotide binding]; other site 482957009306 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 482957009307 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 482957009308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957009309 FeS/SAM binding site; other site 482957009310 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 482957009311 active site 482957009312 multimer interface [polypeptide binding]; other site 482957009313 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 482957009314 YccA-like proteins; Region: YccA_like; cd10433 482957009315 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 482957009316 TRAM domain; Region: TRAM; cl01282 482957009317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957009318 S-adenosylmethionine binding site [chemical binding]; other site 482957009319 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 482957009320 putative catalytic site [active] 482957009321 putative metal binding site [ion binding]; other site 482957009322 putative phosphate binding site [ion binding]; other site 482957009323 putative catalytic site [active] 482957009324 putative phosphate binding site [ion binding]; other site 482957009325 putative metal binding site [ion binding]; other site 482957009326 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 482957009327 active site 482957009328 catalytic site [active] 482957009329 substrate binding site [chemical binding]; other site 482957009330 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 482957009331 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 482957009332 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 482957009333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957009334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957009335 DNA binding residues [nucleotide binding] 482957009336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957009337 Peptidase family M23; Region: Peptidase_M23; pfam01551 482957009338 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 482957009339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957009340 S-adenosylmethionine binding site [chemical binding]; other site 482957009341 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 482957009342 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957009343 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957009344 recombination protein RecR; Reviewed; Region: recR; PRK00076 482957009345 RecR protein; Region: RecR; pfam02132 482957009346 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 482957009347 putative active site [active] 482957009348 putative metal-binding site [ion binding]; other site 482957009349 tetramer interface [polypeptide binding]; other site 482957009350 hypothetical protein; Validated; Region: PRK00153 482957009351 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 482957009352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957009353 Walker A motif; other site 482957009354 ATP binding site [chemical binding]; other site 482957009355 Walker B motif; other site 482957009356 arginine finger; other site 482957009357 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 482957009358 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 482957009359 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957009360 catalytic residues [active] 482957009361 transcription termination factor Rho; Provisional; Region: rho; PRK09376 482957009362 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 482957009363 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 482957009364 RNA binding site [nucleotide binding]; other site 482957009365 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 482957009366 multimer interface [polypeptide binding]; other site 482957009367 Walker A motif; other site 482957009368 ATP binding site [chemical binding]; other site 482957009369 Walker B motif; other site 482957009370 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 482957009371 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 482957009372 DNA binding residues [nucleotide binding] 482957009373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957009374 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957009375 putative substrate translocation pore; other site 482957009376 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 482957009377 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 482957009378 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 482957009379 multidrug efflux protein; Reviewed; Region: PRK01766 482957009380 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 482957009381 cation binding site [ion binding]; other site 482957009382 lipoyl synthase; Provisional; Region: PRK12928 482957009383 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 482957009384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957009385 E3 interaction surface; other site 482957009386 lipoyl attachment site [posttranslational modification]; other site 482957009387 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 482957009388 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 482957009389 alpha subunit interface [polypeptide binding]; other site 482957009390 TPP binding site [chemical binding]; other site 482957009391 heterodimer interface [polypeptide binding]; other site 482957009392 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 482957009393 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 482957009394 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 482957009395 tetramer interface [polypeptide binding]; other site 482957009396 TPP-binding site [chemical binding]; other site 482957009397 heterodimer interface [polypeptide binding]; other site 482957009398 phosphorylation loop region [posttranslational modification] 482957009399 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 482957009400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957009401 NAD(P) binding site [chemical binding]; other site 482957009402 active site 482957009403 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 482957009404 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 482957009405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957009406 Walker A motif; other site 482957009407 ATP binding site [chemical binding]; other site 482957009408 Walker B motif; other site 482957009409 arginine finger; other site 482957009410 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957009411 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 482957009412 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 482957009413 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 482957009414 DNA binding residues [nucleotide binding] 482957009415 putative dimer interface [polypeptide binding]; other site 482957009416 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 482957009417 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 482957009418 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 482957009419 Clp amino terminal domain; Region: Clp_N; pfam02861 482957009420 Clp amino terminal domain; Region: Clp_N; pfam02861 482957009421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957009422 Walker A motif; other site 482957009423 ATP binding site [chemical binding]; other site 482957009424 Walker B motif; other site 482957009425 arginine finger; other site 482957009426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957009427 Walker A motif; other site 482957009428 ATP binding site [chemical binding]; other site 482957009429 Walker B motif; other site 482957009430 arginine finger; other site 482957009431 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 482957009432 Transcriptional regulator; Region: Rrf2; cl17282 482957009433 Rrf2 family protein; Region: rrf2_super; TIGR00738 482957009434 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 482957009435 apolar tunnel; other site 482957009436 heme binding site [chemical binding]; other site 482957009437 dimerization interface [polypeptide binding]; other site 482957009438 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 482957009439 MoaE homodimer interface [polypeptide binding]; other site 482957009440 MoaD interaction [polypeptide binding]; other site 482957009441 active site residues [active] 482957009442 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 482957009443 MoaE interaction surface [polypeptide binding]; other site 482957009444 MoeB interaction surface [polypeptide binding]; other site 482957009445 thiocarboxylated glycine; other site 482957009446 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 482957009447 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 482957009448 dimer interface [polypeptide binding]; other site 482957009449 putative functional site; other site 482957009450 putative MPT binding site; other site 482957009451 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 482957009452 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 482957009453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957009454 catalytic residue [active] 482957009455 homoserine dehydrogenase; Provisional; Region: PRK06349 482957009456 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 482957009457 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 482957009458 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 482957009459 aminotransferase AlaT; Validated; Region: PRK09265 482957009460 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957009461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957009462 homodimer interface [polypeptide binding]; other site 482957009463 catalytic residue [active] 482957009464 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 482957009465 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 482957009466 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 482957009467 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 482957009468 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 482957009469 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 482957009470 inhibitor-cofactor binding pocket; inhibition site 482957009471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957009472 catalytic residue [active] 482957009473 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 482957009474 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 482957009475 Ligand binding site; other site 482957009476 Putative Catalytic site; other site 482957009477 DXD motif; other site 482957009478 putative formyltransferase; Provisional; Region: PRK06988 482957009479 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 482957009480 active site 482957009481 substrate binding site [chemical binding]; other site 482957009482 cosubstrate binding site; other site 482957009483 catalytic site [active] 482957009484 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 482957009485 active site 482957009486 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 482957009487 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 482957009488 NAD binding site [chemical binding]; other site 482957009489 substrate binding site [chemical binding]; other site 482957009490 active site 482957009491 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 482957009492 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 482957009493 putative active site [active] 482957009494 putative catalytic site [active] 482957009495 putative Zn binding site [ion binding]; other site 482957009496 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 482957009497 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957009498 catalytic triad [active] 482957009499 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 482957009500 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 482957009501 putative active site [active] 482957009502 PhoH-like protein; Region: PhoH; pfam02562 482957009503 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 482957009504 NlpC/P60 family; Region: NLPC_P60; pfam00877 482957009505 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 482957009506 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 482957009507 replicative DNA helicase; Provisional; Region: PRK07004 482957009508 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 482957009509 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 482957009510 Walker A motif; other site 482957009511 ATP binding site [chemical binding]; other site 482957009512 Walker B motif; other site 482957009513 DNA binding loops [nucleotide binding] 482957009514 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 482957009515 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 482957009516 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 482957009517 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 482957009518 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 482957009519 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 482957009520 Putative zinc-finger; Region: zf-HC2; pfam13490 482957009521 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 482957009522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957009523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957009524 DNA binding residues [nucleotide binding] 482957009525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957009526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957009527 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957009528 putative effector binding pocket; other site 482957009529 dimerization interface [polypeptide binding]; other site 482957009530 glyoxylate carboligase; Provisional; Region: PRK11269 482957009531 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957009532 PYR/PP interface [polypeptide binding]; other site 482957009533 dimer interface [polypeptide binding]; other site 482957009534 TPP binding site [chemical binding]; other site 482957009535 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957009536 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 482957009537 TPP-binding site [chemical binding]; other site 482957009538 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 482957009539 tartronate semialdehyde reductase; Provisional; Region: PRK15059 482957009540 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957009541 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 482957009542 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957009543 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 482957009544 active site 482957009545 homodimer interface [polypeptide binding]; other site 482957009546 homotetramer interface [polypeptide binding]; other site 482957009547 psiF repeat; Region: PsiF_repeat; pfam07769 482957009548 psiF repeat; Region: PsiF_repeat; pfam07769 482957009549 Domain of unknown function DUF221; Region: DUF221; pfam02714 482957009550 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 482957009551 putative amphipathic alpha helix; other site 482957009552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957009553 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 482957009554 putative ADP-binding pocket [chemical binding]; other site 482957009555 Predicted ATPase [General function prediction only]; Region: COG4637 482957009556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957009557 Walker A/P-loop; other site 482957009558 ATP binding site [chemical binding]; other site 482957009559 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 482957009560 Mechanosensitive ion channel; Region: MS_channel; pfam00924 482957009561 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957009562 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 482957009563 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957009564 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 482957009565 active site 482957009566 DNA polymerase III subunit delta'; Validated; Region: PRK06964 482957009567 DNA polymerase III subunit delta'; Validated; Region: PRK08485 482957009568 thymidylate kinase; Validated; Region: tmk; PRK00698 482957009569 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 482957009570 TMP-binding site; other site 482957009571 ATP-binding site [chemical binding]; other site 482957009572 YceG-like family; Region: YceG; pfam02618 482957009573 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 482957009574 dimerization interface [polypeptide binding]; other site 482957009575 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 482957009576 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 482957009577 NRDE protein; Region: NRDE; cl01315 482957009578 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 482957009579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957009580 Coenzyme A binding pocket [chemical binding]; other site 482957009581 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957009582 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957009583 substrate binding pocket [chemical binding]; other site 482957009584 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 482957009585 CoenzymeA binding site [chemical binding]; other site 482957009586 subunit interaction site [polypeptide binding]; other site 482957009587 PHB binding site; other site 482957009588 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 482957009589 recombination associated protein; Reviewed; Region: rdgC; PRK00321 482957009590 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 482957009591 dimer interface [polypeptide binding]; other site 482957009592 catalytic triad [active] 482957009593 conserved cis-peptide bond; other site 482957009594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957009595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957009596 metal binding site [ion binding]; metal-binding site 482957009597 active site 482957009598 I-site; other site 482957009599 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 482957009600 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957009601 dimer interface [polypeptide binding]; other site 482957009602 active site 482957009603 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 482957009604 Isochorismatase family; Region: Isochorismatase; pfam00857 482957009605 catalytic triad [active] 482957009606 metal binding site [ion binding]; metal-binding site 482957009607 conserved cis-peptide bond; other site 482957009608 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957009609 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 482957009610 substrate binding site [chemical binding]; other site 482957009611 oxyanion hole (OAH) forming residues; other site 482957009612 trimer interface [polypeptide binding]; other site 482957009613 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957009614 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957009615 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957009616 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 482957009617 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 482957009618 dimer interface [polypeptide binding]; other site 482957009619 acyl-activating enzyme (AAE) consensus motif; other site 482957009620 putative active site [active] 482957009621 AMP binding site [chemical binding]; other site 482957009622 putative CoA binding site [chemical binding]; other site 482957009623 Uncharacterized conserved protein [Function unknown]; Region: COG0397 482957009624 hypothetical protein; Validated; Region: PRK00029 482957009625 methionine sulfoxide reductase B; Provisional; Region: PRK00222 482957009626 SelR domain; Region: SelR; pfam01641 482957009627 intracellular septation protein A; Reviewed; Region: PRK00259 482957009628 BolA-like protein; Region: BolA; pfam01722 482957009629 SurA N-terminal domain; Region: SurA_N_3; cl07813 482957009630 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 482957009631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957009632 Coenzyme A binding pocket [chemical binding]; other site 482957009633 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 482957009634 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 482957009635 dimerization interface [polypeptide binding]; other site 482957009636 ATP binding site [chemical binding]; other site 482957009637 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 482957009638 dimerization interface [polypeptide binding]; other site 482957009639 ATP binding site [chemical binding]; other site 482957009640 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 482957009641 putative active site [active] 482957009642 catalytic triad [active] 482957009643 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 482957009644 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 482957009645 putative carbohydrate kinase; Provisional; Region: PRK10565 482957009646 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 482957009647 putative substrate binding site [chemical binding]; other site 482957009648 putative ATP binding site [chemical binding]; other site 482957009649 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 482957009650 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 482957009651 active site 482957009652 dimer interface [polypeptide binding]; other site 482957009653 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 482957009654 dimer interface [polypeptide binding]; other site 482957009655 active site 482957009656 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 482957009657 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 482957009658 Walker A/P-loop; other site 482957009659 ATP binding site [chemical binding]; other site 482957009660 Q-loop/lid; other site 482957009661 ABC transporter signature motif; other site 482957009662 Walker B; other site 482957009663 D-loop; other site 482957009664 H-loop/switch region; other site 482957009665 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 482957009666 active site 482957009667 catalytic triad [active] 482957009668 oxyanion hole [active] 482957009669 switch loop; other site 482957009670 SurA N-terminal domain; Region: SurA_N_3; cl07813 482957009671 periplasmic folding chaperone; Provisional; Region: PRK10788 482957009672 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 482957009673 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 482957009674 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 482957009675 Found in ATP-dependent protease La (LON); Region: LON; smart00464 482957009676 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957009677 Walker A motif; other site 482957009678 ATP binding site [chemical binding]; other site 482957009679 Walker B motif; other site 482957009680 arginine finger; other site 482957009681 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 482957009682 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 482957009683 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 482957009684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957009685 Walker A motif; other site 482957009686 ATP binding site [chemical binding]; other site 482957009687 Walker B motif; other site 482957009688 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 482957009689 Clp protease; Region: CLP_protease; pfam00574 482957009690 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 482957009691 oligomer interface [polypeptide binding]; other site 482957009692 active site residues [active] 482957009693 trigger factor; Provisional; Region: tig; PRK01490 482957009694 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 482957009695 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 482957009696 Glycerate kinase family; Region: Gly_kinase; cl00841 482957009697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957009698 MarR family; Region: MarR_2; pfam12802 482957009699 MarR family; Region: MarR_2; cl17246 482957009700 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 482957009701 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 482957009702 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 482957009703 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957009704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957009705 dimerization interface [polypeptide binding]; other site 482957009706 DNA binding residues [nucleotide binding] 482957009707 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957009708 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957009709 trimer interface [polypeptide binding]; other site 482957009710 eyelet of channel; other site 482957009711 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 482957009712 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 482957009713 active site 482957009714 Zn binding site [ion binding]; other site 482957009715 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 482957009716 active site flap/lid [active] 482957009717 nucleophilic elbow; other site 482957009718 catalytic triad [active] 482957009719 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 482957009720 putative trimer interface [polypeptide binding]; other site 482957009721 putative CoA binding site [chemical binding]; other site 482957009722 HNH endonuclease; Region: HNH_3; pfam13392 482957009723 PrkA family serine protein kinase; Provisional; Region: PRK15455 482957009724 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 482957009725 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 482957009726 active site lid residues [active] 482957009727 substrate binding pocket [chemical binding]; other site 482957009728 catalytic residues [active] 482957009729 substrate-Mg2+ binding site; other site 482957009730 aspartate-rich region 1; other site 482957009731 aspartate-rich region 2; other site 482957009732 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 482957009733 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 482957009734 osmolarity response regulator; Provisional; Region: ompR; PRK09468 482957009735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957009736 active site 482957009737 phosphorylation site [posttranslational modification] 482957009738 intermolecular recognition site; other site 482957009739 dimerization interface [polypeptide binding]; other site 482957009740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957009741 DNA binding site [nucleotide binding] 482957009742 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 482957009743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957009744 dimer interface [polypeptide binding]; other site 482957009745 phosphorylation site [posttranslational modification] 482957009746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957009747 ATP binding site [chemical binding]; other site 482957009748 Mg2+ binding site [ion binding]; other site 482957009749 G-X-G motif; other site 482957009750 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 482957009751 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 482957009752 dimer interface [polypeptide binding]; other site 482957009753 decamer (pentamer of dimers) interface [polypeptide binding]; other site 482957009754 catalytic triad [active] 482957009755 peroxidatic and resolving cysteines [active] 482957009756 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 482957009757 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957009758 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 482957009759 homotrimer interaction site [polypeptide binding]; other site 482957009760 zinc binding site [ion binding]; other site 482957009761 CDP-binding sites; other site 482957009762 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 482957009763 substrate binding site; other site 482957009764 dimer interface; other site 482957009765 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 482957009766 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 482957009767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957009768 ATP binding site [chemical binding]; other site 482957009769 putative Mg++ binding site [ion binding]; other site 482957009770 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957009771 nucleotide binding region [chemical binding]; other site 482957009772 ATP-binding site [chemical binding]; other site 482957009773 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 482957009774 acetylornithine deacetylase; Provisional; Region: PRK07522 482957009775 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 482957009776 metal binding site [ion binding]; metal-binding site 482957009777 putative dimer interface [polypeptide binding]; other site 482957009778 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 482957009779 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 482957009780 tetramer interface [polypeptide binding]; other site 482957009781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957009782 catalytic residue [active] 482957009783 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 482957009784 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 482957009785 Transglycosylase; Region: Transgly; pfam00912 482957009786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 482957009787 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 482957009788 Tetratricopeptide repeat; Region: TPR_16; pfam13432 482957009789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957009790 TPR motif; other site 482957009791 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 482957009792 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 482957009793 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957009794 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 482957009795 Dodecin; Region: Dodecin; pfam07311 482957009796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957009797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957009798 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 482957009799 putative substrate binding pocket [chemical binding]; other site 482957009800 putative dimerization interface [polypeptide binding]; other site 482957009801 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 482957009802 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 482957009803 active site 482957009804 putative substrate binding pocket [chemical binding]; other site 482957009805 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 482957009806 active site 482957009807 homotetramer interface [polypeptide binding]; other site 482957009808 Predicted membrane protein [Function unknown]; Region: COG3748 482957009809 Protein of unknown function (DUF989); Region: DUF989; pfam06181 482957009810 Cytochrome c; Region: Cytochrom_C; pfam00034 482957009811 ACT domain; Region: ACT_3; pfam10000 482957009812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 482957009813 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 482957009814 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957009815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957009816 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957009817 dimerization interface [polypeptide binding]; other site 482957009818 substrate binding pocket [chemical binding]; other site 482957009819 hypothetical protein; Provisional; Region: PRK09266 482957009820 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 482957009821 substrate-cofactor binding pocket; other site 482957009822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957009823 homodimer interface [polypeptide binding]; other site 482957009824 catalytic residue [active] 482957009825 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 482957009826 homotrimer interaction site [polypeptide binding]; other site 482957009827 putative active site [active] 482957009828 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957009829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957009830 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957009831 putative effector binding pocket; other site 482957009832 putative dimerization interface [polypeptide binding]; other site 482957009833 ureidoglycolate hydrolase; Provisional; Region: PRK03606 482957009834 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 482957009835 allantoicase; Provisional; Region: PRK13257 482957009836 Allantoicase repeat; Region: Allantoicase; pfam03561 482957009837 Allantoicase repeat; Region: Allantoicase; pfam03561 482957009838 OHCU decarboxylase; Region: UHCUDC; TIGR03164 482957009839 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 482957009840 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 482957009841 active site 482957009842 catalytic site [active] 482957009843 tetramer interface [polypeptide binding]; other site 482957009844 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 482957009845 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 482957009846 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957009847 Na binding site [ion binding]; other site 482957009848 putative substrate binding site [chemical binding]; other site 482957009849 Transcriptional regulators [Transcription]; Region: GntR; COG1802 482957009850 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957009851 DNA-binding site [nucleotide binding]; DNA binding site 482957009852 FCD domain; Region: FCD; pfam07729 482957009853 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 482957009854 dimer interface [polypeptide binding]; other site 482957009855 catalytic triad [active] 482957009856 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 482957009857 nucleoside/Zn binding site; other site 482957009858 dimer interface [polypeptide binding]; other site 482957009859 catalytic motif [active] 482957009860 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 482957009861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957009862 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957009863 putative substrate translocation pore; other site 482957009864 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 482957009865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957009866 DNA-binding site [nucleotide binding]; DNA binding site 482957009867 UTRA domain; Region: UTRA; pfam07702 482957009868 putative oxidoreductase; Provisional; Region: PRK08275 482957009869 L-aspartate oxidase; Provisional; Region: PRK06175 482957009870 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 482957009871 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 482957009872 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 482957009873 HEAT repeats; Region: HEAT_2; pfam13646 482957009874 HEAT repeats; Region: HEAT_2; pfam13646 482957009875 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 482957009876 HEAT repeats; Region: HEAT_2; pfam13646 482957009877 protein binding surface [polypeptide binding]; other site 482957009878 Protein of unknown function (DUF971); Region: DUF971; pfam06155 482957009879 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957009880 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957009881 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 482957009882 nudix motif; other site 482957009883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957009884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957009885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957009886 Coenzyme A binding pocket [chemical binding]; other site 482957009887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957009888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957009889 Putative amidotransferase; Region: DUF4066; pfam13278 482957009890 conserved cys residue [active] 482957009891 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 482957009892 active site 482957009893 catalytic site [active] 482957009894 substrate binding site [chemical binding]; other site 482957009895 GMP synthase; Reviewed; Region: guaA; PRK00074 482957009896 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 482957009897 AMP/PPi binding site [chemical binding]; other site 482957009898 candidate oxyanion hole; other site 482957009899 catalytic triad [active] 482957009900 potential glutamine specificity residues [chemical binding]; other site 482957009901 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 482957009902 ATP Binding subdomain [chemical binding]; other site 482957009903 Ligand Binding sites [chemical binding]; other site 482957009904 Dimerization subdomain; other site 482957009905 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 482957009906 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 482957009907 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 482957009908 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 482957009909 active site 482957009910 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 482957009911 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 482957009912 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 482957009913 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 482957009914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 482957009915 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 482957009916 putative coenzyme Q binding site [chemical binding]; other site 482957009917 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 482957009918 SmpB-tmRNA interface; other site 482957009919 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 482957009920 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 482957009921 phosphoenolpyruvate synthase; Validated; Region: PRK06464 482957009922 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 482957009923 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 482957009924 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 482957009925 PEP synthetase regulatory protein; Provisional; Region: PRK05339 482957009926 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 482957009927 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 482957009928 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 482957009929 RNA/DNA hybrid binding site [nucleotide binding]; other site 482957009930 active site 482957009931 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 482957009932 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 482957009933 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 482957009934 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 482957009935 active site 482957009936 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 482957009937 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 482957009938 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 482957009939 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 482957009940 trimer interface [polypeptide binding]; other site 482957009941 active site 482957009942 UDP-GlcNAc binding site [chemical binding]; other site 482957009943 lipid binding site [chemical binding]; lipid-binding site 482957009944 periplasmic chaperone; Provisional; Region: PRK10780 482957009945 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 482957009946 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 482957009947 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 482957009948 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 482957009949 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 482957009950 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 482957009951 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 482957009952 Surface antigen; Region: Bac_surface_Ag; pfam01103 482957009953 zinc metallopeptidase RseP; Provisional; Region: PRK10779 482957009954 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 482957009955 active site 482957009956 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 482957009957 protein binding site [polypeptide binding]; other site 482957009958 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 482957009959 putative substrate binding region [chemical binding]; other site 482957009960 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 482957009961 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 482957009962 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 482957009963 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 482957009964 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 482957009965 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 482957009966 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 482957009967 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 482957009968 catalytic residue [active] 482957009969 putative FPP diphosphate binding site; other site 482957009970 putative FPP binding hydrophobic cleft; other site 482957009971 dimer interface [polypeptide binding]; other site 482957009972 putative IPP diphosphate binding site; other site 482957009973 ribosome recycling factor; Reviewed; Region: frr; PRK00083 482957009974 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 482957009975 hinge region; other site 482957009976 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 482957009977 putative nucleotide binding site [chemical binding]; other site 482957009978 uridine monophosphate binding site [chemical binding]; other site 482957009979 homohexameric interface [polypeptide binding]; other site 482957009980 elongation factor Ts; Provisional; Region: tsf; PRK09377 482957009981 UBA/TS-N domain; Region: UBA; pfam00627 482957009982 Elongation factor TS; Region: EF_TS; pfam00889 482957009983 Elongation factor TS; Region: EF_TS; pfam00889 482957009984 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 482957009985 rRNA interaction site [nucleotide binding]; other site 482957009986 S8 interaction site; other site 482957009987 putative laminin-1 binding site; other site 482957009988 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 482957009989 active site 482957009990 PII uridylyl-transferase; Provisional; Region: PRK03059 482957009991 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 482957009992 metal binding triad; other site 482957009993 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 482957009994 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 482957009995 Zn2+ binding site [ion binding]; other site 482957009996 Mg2+ binding site [ion binding]; other site 482957009997 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 482957009998 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 482957009999 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 482957010000 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957010001 RNA binding surface [nucleotide binding]; other site 482957010002 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 482957010003 active site 482957010004 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 482957010005 active site 482957010006 catalytic residues [active] 482957010007 metal binding site [ion binding]; metal-binding site 482957010008 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 482957010009 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 482957010010 nucleotide binding pocket [chemical binding]; other site 482957010011 K-X-D-G motif; other site 482957010012 catalytic site [active] 482957010013 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 482957010014 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 482957010015 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 482957010016 Dimer interface [polypeptide binding]; other site 482957010017 BRCT sequence motif; other site 482957010018 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 482957010019 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 482957010020 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 482957010021 Walker A/P-loop; other site 482957010022 ATP binding site [chemical binding]; other site 482957010023 Q-loop/lid; other site 482957010024 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 482957010025 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 482957010026 Q-loop/lid; other site 482957010027 ABC transporter signature motif; other site 482957010028 Walker B; other site 482957010029 D-loop; other site 482957010030 H-loop/switch region; other site 482957010031 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957010032 EamA-like transporter family; Region: EamA; pfam00892 482957010033 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 482957010034 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957010035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957010036 homodimer interface [polypeptide binding]; other site 482957010037 catalytic residue [active] 482957010038 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 482957010039 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 482957010040 trimer interface [polypeptide binding]; other site 482957010041 active site 482957010042 substrate binding site [chemical binding]; other site 482957010043 CoA binding site [chemical binding]; other site 482957010044 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 482957010045 ArsC family; Region: ArsC; pfam03960 482957010046 putative catalytic residues [active] 482957010047 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 482957010048 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 482957010049 metal binding site [ion binding]; metal-binding site 482957010050 dimer interface [polypeptide binding]; other site 482957010051 HemK family putative methylases; Region: hemK_fam; TIGR00536 482957010052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957010053 S-adenosylmethionine binding site [chemical binding]; other site 482957010054 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 482957010055 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 482957010056 putative active site [active] 482957010057 catalytic site [active] 482957010058 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 482957010059 putative active site [active] 482957010060 catalytic site [active] 482957010061 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 482957010062 catalytic residues [active] 482957010063 dimer interface [polypeptide binding]; other site 482957010064 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 482957010065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957010066 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957010067 ABC transporter; Region: ABC_tran_2; pfam12848 482957010068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957010069 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 482957010070 DNA repair protein RadA; Provisional; Region: PRK11823 482957010071 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 482957010072 Walker A motif/ATP binding site; other site 482957010073 ATP binding site [chemical binding]; other site 482957010074 Walker B motif; other site 482957010075 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 482957010076 alanine racemase; Reviewed; Region: alr; PRK00053 482957010077 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 482957010078 active site 482957010079 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957010080 substrate binding site [chemical binding]; other site 482957010081 catalytic residues [active] 482957010082 dimer interface [polypeptide binding]; other site 482957010083 lysophospholipid transporter LplT; Provisional; Region: PRK11195 482957010084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 482957010085 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 482957010086 dimer interface [polypeptide binding]; other site 482957010087 substrate binding site [chemical binding]; other site 482957010088 ATP binding site [chemical binding]; other site 482957010089 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 482957010090 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 482957010091 Fe-S cluster binding site [ion binding]; other site 482957010092 active site 482957010093 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 482957010094 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957010095 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 482957010096 Glycoprotease family; Region: Peptidase_M22; pfam00814 482957010097 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 482957010098 acyl-CoA binding pocket [chemical binding]; other site 482957010099 CoA binding site [chemical binding]; other site 482957010100 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 482957010101 DEAD-like helicases superfamily; Region: DEXDc; smart00487 482957010102 ATP binding site [chemical binding]; other site 482957010103 Mg++ binding site [ion binding]; other site 482957010104 motif III; other site 482957010105 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957010106 nucleotide binding region [chemical binding]; other site 482957010107 ATP-binding site [chemical binding]; other site 482957010108 isocitrate lyase; Provisional; Region: PRK15063 482957010109 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 482957010110 tetramer interface [polypeptide binding]; other site 482957010111 active site 482957010112 Mg2+/Mn2+ binding site [ion binding]; other site 482957010113 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957010114 Ligand Binding Site [chemical binding]; other site 482957010115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957010116 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957010117 putative effector binding pocket; other site 482957010118 dimerization interface [polypeptide binding]; other site 482957010119 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 482957010120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957010121 motif II; other site 482957010122 malate synthase A; Region: malate_syn_A; TIGR01344 482957010123 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 482957010124 active site 482957010125 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 482957010126 putative active site pocket [active] 482957010127 dimerization interface [polypeptide binding]; other site 482957010128 putative catalytic residue [active] 482957010129 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957010130 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957010131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957010132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957010133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957010134 Coenzyme A binding pocket [chemical binding]; other site 482957010135 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 482957010136 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 482957010137 active site 482957010138 HIGH motif; other site 482957010139 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 482957010140 active site 482957010141 KMSKS motif; other site 482957010142 hypothetical protein; Provisional; Region: PRK10279 482957010143 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 482957010144 nucleophile elbow; other site 482957010145 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 482957010146 NlpC/P60 family; Region: NLPC_P60; pfam00877 482957010147 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 482957010148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957010149 Walker A/P-loop; other site 482957010150 ATP binding site [chemical binding]; other site 482957010151 Q-loop/lid; other site 482957010152 ABC transporter signature motif; other site 482957010153 Walker B; other site 482957010154 D-loop; other site 482957010155 H-loop/switch region; other site 482957010156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957010157 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957010158 Walker A/P-loop; other site 482957010159 ATP binding site [chemical binding]; other site 482957010160 Q-loop/lid; other site 482957010161 ABC transporter signature motif; other site 482957010162 Walker B; other site 482957010163 D-loop; other site 482957010164 H-loop/switch region; other site 482957010165 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957010166 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 482957010167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957010168 dimer interface [polypeptide binding]; other site 482957010169 conserved gate region; other site 482957010170 putative PBP binding loops; other site 482957010171 ABC-ATPase subunit interface; other site 482957010172 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 482957010173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957010174 dimer interface [polypeptide binding]; other site 482957010175 conserved gate region; other site 482957010176 putative PBP binding loops; other site 482957010177 ABC-ATPase subunit interface; other site 482957010178 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 482957010179 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 482957010180 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 482957010181 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 482957010182 Subunit I/III interface [polypeptide binding]; other site 482957010183 Subunit III/IV interface [polypeptide binding]; other site 482957010184 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 482957010185 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 482957010186 D-pathway; other site 482957010187 Putative ubiquinol binding site [chemical binding]; other site 482957010188 Low-spin heme (heme b) binding site [chemical binding]; other site 482957010189 Putative water exit pathway; other site 482957010190 Binuclear center (heme o3/CuB) [ion binding]; other site 482957010191 K-pathway; other site 482957010192 Putative proton exit pathway; other site 482957010193 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 482957010194 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 482957010195 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 482957010196 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 482957010197 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 482957010198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957010199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957010200 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957010201 putative effector binding pocket; other site 482957010202 dimerization interface [polypeptide binding]; other site 482957010203 Isochorismatase family; Region: Isochorismatase; pfam00857 482957010204 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 482957010205 catalytic triad [active] 482957010206 conserved cis-peptide bond; other site 482957010207 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957010208 homotrimer interaction site [polypeptide binding]; other site 482957010209 putative active site [active] 482957010210 aspartate kinase; Reviewed; Region: PRK06635 482957010211 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 482957010212 putative nucleotide binding site [chemical binding]; other site 482957010213 putative catalytic residues [active] 482957010214 putative Mg ion binding site [ion binding]; other site 482957010215 putative aspartate binding site [chemical binding]; other site 482957010216 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 482957010217 putative allosteric regulatory site; other site 482957010218 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 482957010219 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 482957010220 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 482957010221 Ligand Binding Site [chemical binding]; other site 482957010222 TilS substrate binding domain; Region: TilS; pfam09179 482957010223 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 482957010224 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 482957010225 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 482957010226 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 482957010227 endonuclease III; Region: ENDO3c; smart00478 482957010228 minor groove reading motif; other site 482957010229 helix-hairpin-helix signature motif; other site 482957010230 substrate binding pocket [chemical binding]; other site 482957010231 active site 482957010232 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 482957010233 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 482957010234 active site 482957010235 HIGH motif; other site 482957010236 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 482957010237 KMSKS motif; other site 482957010238 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 482957010239 tRNA binding surface [nucleotide binding]; other site 482957010240 anticodon binding site; other site 482957010241 TPR repeat; Region: TPR_11; pfam13414 482957010242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957010243 binding surface 482957010244 TPR motif; other site 482957010245 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 482957010246 substrate binding site [chemical binding]; other site 482957010247 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 482957010248 substrate binding site [chemical binding]; other site 482957010249 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 482957010250 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 482957010251 putative active site [active] 482957010252 putative metal binding site [ion binding]; other site 482957010253 serine O-acetyltransferase; Region: cysE; TIGR01172 482957010254 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 482957010255 trimer interface [polypeptide binding]; other site 482957010256 active site 482957010257 substrate binding site [chemical binding]; other site 482957010258 CoA binding site [chemical binding]; other site 482957010259 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 482957010260 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 482957010261 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 482957010262 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 482957010263 active site 482957010264 dimerization interface [polypeptide binding]; other site 482957010265 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 482957010266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957010267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957010268 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 482957010269 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 482957010270 MutS domain I; Region: MutS_I; pfam01624 482957010271 MutS domain II; Region: MutS_II; pfam05188 482957010272 MutS domain III; Region: MutS_III; pfam05192 482957010273 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 482957010274 Walker A/P-loop; other site 482957010275 ATP binding site [chemical binding]; other site 482957010276 Q-loop/lid; other site 482957010277 ABC transporter signature motif; other site 482957010278 Walker B; other site 482957010279 D-loop; other site 482957010280 H-loop/switch region; other site 482957010281 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 482957010282 Uncharacterized conserved protein [Function unknown]; Region: COG2850 482957010283 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 482957010284 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 482957010285 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 482957010286 dihydrodipicolinate synthase; Region: dapA; TIGR00674 482957010287 dimer interface [polypeptide binding]; other site 482957010288 active site 482957010289 catalytic residue [active] 482957010290 Methyltransferase domain; Region: Methyltransf_18; pfam12847 482957010291 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 482957010292 active site 482957010293 HIGH motif; other site 482957010294 dimer interface [polypeptide binding]; other site 482957010295 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957010296 active site 482957010297 KMSKS motif; other site 482957010298 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 482957010299 Peptidase family M50; Region: Peptidase_M50; pfam02163 482957010300 active site 482957010301 putative substrate binding region [chemical binding]; other site 482957010302 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 482957010303 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 482957010304 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 482957010305 active site 482957010306 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 482957010307 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957010308 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957010309 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957010310 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 482957010311 dinuclear metal binding motif [ion binding]; other site 482957010312 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 482957010313 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 482957010314 trimer interface [polypeptide binding]; other site 482957010315 putative metal binding site [ion binding]; other site 482957010316 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 482957010317 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 482957010318 dimerization interface [polypeptide binding]; other site 482957010319 domain crossover interface; other site 482957010320 redox-dependent activation switch; other site 482957010321 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 482957010322 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 482957010323 enolase; Provisional; Region: eno; PRK00077 482957010324 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 482957010325 dimer interface [polypeptide binding]; other site 482957010326 metal binding site [ion binding]; metal-binding site 482957010327 substrate binding pocket [chemical binding]; other site 482957010328 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 482957010329 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 482957010330 CTP synthetase; Validated; Region: pyrG; PRK05380 482957010331 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 482957010332 Catalytic site [active] 482957010333 active site 482957010334 UTP binding site [chemical binding]; other site 482957010335 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 482957010336 active site 482957010337 putative oxyanion hole; other site 482957010338 catalytic triad [active] 482957010339 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 482957010340 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957010341 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 482957010342 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 482957010343 Competence protein; Region: Competence; pfam03772 482957010344 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 482957010345 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 482957010346 active site 482957010347 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 482957010348 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 482957010349 Walker A/P-loop; other site 482957010350 ATP binding site [chemical binding]; other site 482957010351 Q-loop/lid; other site 482957010352 ABC transporter signature motif; other site 482957010353 Walker B; other site 482957010354 D-loop; other site 482957010355 H-loop/switch region; other site 482957010356 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 482957010357 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 482957010358 FtsX-like permease family; Region: FtsX; pfam02687 482957010359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 482957010360 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 482957010361 DHH family; Region: DHH; pfam01368 482957010362 DHHA1 domain; Region: DHHA1; pfam02272 482957010363 peptide chain release factor 2; Validated; Region: prfB; PRK00578 482957010364 This domain is found in peptide chain release factors; Region: PCRF; smart00937 482957010365 RF-1 domain; Region: RF-1; pfam00472 482957010366 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 482957010367 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 482957010368 dimer interface [polypeptide binding]; other site 482957010369 putative anticodon binding site; other site 482957010370 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 482957010371 motif 1; other site 482957010372 active site 482957010373 motif 2; other site 482957010374 motif 3; other site 482957010375 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 482957010376 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 482957010377 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957010378 catalytic loop [active] 482957010379 iron binding site [ion binding]; other site 482957010380 chaperone protein HscA; Provisional; Region: hscA; PRK05183 482957010381 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 482957010382 nucleotide binding site [chemical binding]; other site 482957010383 putative NEF/HSP70 interaction site [polypeptide binding]; other site 482957010384 SBD interface [polypeptide binding]; other site 482957010385 co-chaperone HscB; Provisional; Region: hscB; PRK03578 482957010386 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 482957010387 HSP70 interaction site [polypeptide binding]; other site 482957010388 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 482957010389 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 482957010390 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 482957010391 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 482957010392 trimerization site [polypeptide binding]; other site 482957010393 active site 482957010394 cysteine desulfurase; Provisional; Region: PRK14012 482957010395 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 482957010396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957010397 catalytic residue [active] 482957010398 Predicted transcriptional regulator [Transcription]; Region: COG1959 482957010399 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 482957010400 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 482957010401 Low molecular weight phosphatase family; Region: LMWPc; cd00115 482957010402 active site 482957010403 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 482957010404 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 482957010405 4Fe-4S binding domain; Region: Fer4; pfam00037 482957010406 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 482957010407 Cysteine-rich domain; Region: CCG; pfam02754 482957010408 Cysteine-rich domain; Region: CCG; pfam02754 482957010409 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957010410 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957010411 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957010412 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 482957010413 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 482957010414 Phasin protein; Region: Phasin_2; pfam09361 482957010415 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957010416 E3 interaction surface; other site 482957010417 lipoyl attachment site [posttranslational modification]; other site 482957010418 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 482957010419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957010420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957010421 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 482957010422 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 482957010423 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957010424 E3 interaction surface; other site 482957010425 lipoyl attachment site [posttranslational modification]; other site 482957010426 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957010427 E3 interaction surface; other site 482957010428 lipoyl attachment site [posttranslational modification]; other site 482957010429 e3 binding domain; Region: E3_binding; pfam02817 482957010430 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 482957010431 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 482957010432 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 482957010433 dimer interface [polypeptide binding]; other site 482957010434 TPP-binding site [chemical binding]; other site 482957010435 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 482957010436 PAS domain S-box; Region: sensory_box; TIGR00229 482957010437 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957010438 putative active site [active] 482957010439 heme pocket [chemical binding]; other site 482957010440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957010441 dimer interface [polypeptide binding]; other site 482957010442 phosphorylation site [posttranslational modification] 482957010443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957010444 ATP binding site [chemical binding]; other site 482957010445 Mg2+ binding site [ion binding]; other site 482957010446 G-X-G motif; other site 482957010447 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 482957010448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957010449 active site 482957010450 phosphorylation site [posttranslational modification] 482957010451 intermolecular recognition site; other site 482957010452 dimerization interface [polypeptide binding]; other site 482957010453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957010454 DNA binding residues [nucleotide binding] 482957010455 dimerization interface [polypeptide binding]; other site 482957010456 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 482957010457 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 482957010458 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 482957010459 homodimer interface [polypeptide binding]; other site 482957010460 NADP binding site [chemical binding]; other site 482957010461 substrate binding site [chemical binding]; other site 482957010462 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 482957010463 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 482957010464 active site 482957010465 Zn binding site [ion binding]; other site 482957010466 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 482957010467 active site 482957010468 DNA polymerase IV; Validated; Region: PRK02406 482957010469 DNA binding site [nucleotide binding] 482957010470 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 482957010471 aspartate racemase; Region: asp_race; TIGR00035 482957010472 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 482957010473 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 482957010474 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957010475 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957010476 N-terminal plug; other site 482957010477 ligand-binding site [chemical binding]; other site 482957010478 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 482957010479 FecR protein; Region: FecR; pfam04773 482957010480 RNA polymerase sigma factor; Provisional; Region: PRK12528 482957010481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957010482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957010483 DNA binding residues [nucleotide binding] 482957010484 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 482957010485 putative catalytic site [active] 482957010486 putative phosphate binding site [ion binding]; other site 482957010487 active site 482957010488 metal binding site A [ion binding]; metal-binding site 482957010489 DNA binding site [nucleotide binding] 482957010490 putative AP binding site [nucleotide binding]; other site 482957010491 putative metal binding site B [ion binding]; other site 482957010492 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 482957010493 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957010494 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 482957010495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957010496 active site 482957010497 phosphorylation site [posttranslational modification] 482957010498 intermolecular recognition site; other site 482957010499 dimerization interface [polypeptide binding]; other site 482957010500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957010501 Walker A motif; other site 482957010502 ATP binding site [chemical binding]; other site 482957010503 Walker B motif; other site 482957010504 arginine finger; other site 482957010505 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957010506 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 482957010507 PAS domain; Region: PAS; smart00091 482957010508 putative active site [active] 482957010509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957010510 dimer interface [polypeptide binding]; other site 482957010511 phosphorylation site [posttranslational modification] 482957010512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957010513 ATP binding site [chemical binding]; other site 482957010514 Mg2+ binding site [ion binding]; other site 482957010515 G-X-G motif; other site 482957010516 glutamine synthetase; Provisional; Region: glnA; PRK09469 482957010517 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 482957010518 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 482957010519 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 482957010520 active site residue [active] 482957010521 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 482957010522 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 482957010523 putative MPT binding site; other site 482957010524 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 482957010525 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 482957010526 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 482957010527 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 482957010528 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 482957010529 structural tetrad; other site 482957010530 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 482957010531 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 482957010532 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957010533 ATP binding site [chemical binding]; other site 482957010534 putative Mg++ binding site [ion binding]; other site 482957010535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957010536 nucleotide binding region [chemical binding]; other site 482957010537 ATP-binding site [chemical binding]; other site 482957010538 Helicase associated domain (HA2); Region: HA2; pfam04408 482957010539 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 482957010540 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 482957010541 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 482957010542 N-acetylglutamate synthase; Validated; Region: PRK05279 482957010543 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 482957010544 putative feedback inhibition sensing region; other site 482957010545 putative nucleotide binding site [chemical binding]; other site 482957010546 putative substrate binding site [chemical binding]; other site 482957010547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957010548 Coenzyme A binding pocket [chemical binding]; other site 482957010549 oxidative damage protection protein; Provisional; Region: PRK05408 482957010550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957010551 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957010552 putative substrate translocation pore; other site 482957010553 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957010554 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957010555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957010556 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957010557 active site 482957010558 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 482957010559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957010560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957010561 dimerization interface [polypeptide binding]; other site 482957010562 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 482957010563 ligand-binding site [chemical binding]; other site 482957010564 putative aminotransferase; Validated; Region: PRK07480 482957010565 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957010566 inhibitor-cofactor binding pocket; inhibition site 482957010567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957010568 catalytic residue [active] 482957010569 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 482957010570 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 482957010571 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 482957010572 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 482957010573 catalytic triad [active] 482957010574 N-formylglutamate amidohydrolase; Region: FGase; cl01522 482957010575 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 482957010576 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 482957010577 active site 482957010578 imidazolonepropionase; Validated; Region: PRK09356 482957010579 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 482957010580 active site 482957010581 HutD; Region: HutD; pfam05962 482957010582 urocanate hydratase; Provisional; Region: PRK05414 482957010583 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 482957010584 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957010585 DNA-binding site [nucleotide binding]; DNA binding site 482957010586 UTRA domain; Region: UTRA; pfam07702 482957010587 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 482957010588 active sites [active] 482957010589 tetramer interface [polypeptide binding]; other site 482957010590 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 482957010591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957010592 substrate binding pocket [chemical binding]; other site 482957010593 membrane-bound complex binding site; other site 482957010594 hinge residues; other site 482957010595 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 482957010596 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 482957010597 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 482957010598 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957010599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957010600 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957010601 dimerization interface [polypeptide binding]; other site 482957010602 substrate binding pocket [chemical binding]; other site 482957010603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957010604 putative substrate translocation pore; other site 482957010605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957010606 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 482957010607 DNA photolyase; Region: DNA_photolyase; pfam00875 482957010608 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 482957010609 putative hydrophobic ligand binding site [chemical binding]; other site 482957010610 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 482957010611 SnoaL-like domain; Region: SnoaL_3; pfam13474 482957010612 short chain dehydrogenase; Provisional; Region: PRK07890 482957010613 classical (c) SDRs; Region: SDR_c; cd05233 482957010614 NAD(P) binding site [chemical binding]; other site 482957010615 active site 482957010616 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 482957010617 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 482957010618 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 482957010619 Active Sites [active] 482957010620 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 482957010621 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 482957010622 CysD dimerization site [polypeptide binding]; other site 482957010623 G1 box; other site 482957010624 putative GEF interaction site [polypeptide binding]; other site 482957010625 GTP/Mg2+ binding site [chemical binding]; other site 482957010626 Switch I region; other site 482957010627 G2 box; other site 482957010628 G3 box; other site 482957010629 Switch II region; other site 482957010630 G4 box; other site 482957010631 G5 box; other site 482957010632 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 482957010633 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 482957010634 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 482957010635 ligand-binding site [chemical binding]; other site 482957010636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957010637 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957010638 DNA binding residues [nucleotide binding] 482957010639 dimerization interface [polypeptide binding]; other site 482957010640 D-galactonate transporter; Region: 2A0114; TIGR00893 482957010641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957010642 putative substrate translocation pore; other site 482957010643 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 482957010644 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957010645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957010646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957010647 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957010648 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 482957010649 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 482957010650 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 482957010651 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 482957010652 putative metal binding site [ion binding]; other site 482957010653 hypothetical protein; Provisional; Region: PRK14013 482957010654 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 482957010655 Uncharacterized conserved protein [Function unknown]; Region: COG4104 482957010656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 482957010657 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957010658 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957010659 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957010660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 482957010661 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957010662 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957010663 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957010664 N-terminal plug; other site 482957010665 ligand-binding site [chemical binding]; other site 482957010666 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 482957010667 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 482957010668 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 482957010669 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 482957010670 acetyl-CoA synthetase; Provisional; Region: PRK00174 482957010671 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 482957010672 active site 482957010673 CoA binding site [chemical binding]; other site 482957010674 acyl-activating enzyme (AAE) consensus motif; other site 482957010675 AMP binding site [chemical binding]; other site 482957010676 acetate binding site [chemical binding]; other site 482957010677 EamA-like transporter family; Region: EamA; pfam00892 482957010678 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 482957010679 EamA-like transporter family; Region: EamA; pfam00892 482957010680 hypothetical protein; Provisional; Region: PRK05208 482957010681 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 482957010682 Fumarase C-terminus; Region: Fumerase_C; pfam05683 482957010683 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 482957010684 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 482957010685 heme binding site [chemical binding]; other site 482957010686 ferroxidase pore; other site 482957010687 ferroxidase diiron center [ion binding]; other site 482957010688 glutamate racemase; Provisional; Region: PRK00865 482957010689 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 482957010690 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 482957010691 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 482957010692 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 482957010693 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957010694 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957010695 LysR family transcriptional regulator; Provisional; Region: PRK14997 482957010696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957010697 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 482957010698 putative effector binding pocket; other site 482957010699 putative dimerization interface [polypeptide binding]; other site 482957010700 Pirin-related protein [General function prediction only]; Region: COG1741 482957010701 Pirin; Region: Pirin; pfam02678 482957010702 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 482957010703 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 482957010704 putative hydrophobic ligand binding site [chemical binding]; other site 482957010705 Hemin uptake protein hemP; Region: hemP; pfam10636 482957010706 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 482957010707 4Fe-4S binding domain; Region: Fer4_5; pfam12801 482957010708 Iron permease FTR1 family; Region: FTR1; cl00475 482957010709 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 482957010710 Fe2+ transport protein; Region: Iron_transport; pfam10634 482957010711 excinuclease ABC subunit B; Provisional; Region: PRK05298 482957010712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957010713 ATP binding site [chemical binding]; other site 482957010714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957010715 nucleotide binding region [chemical binding]; other site 482957010716 ATP-binding site [chemical binding]; other site 482957010717 Ultra-violet resistance protein B; Region: UvrB; pfam12344 482957010718 UvrB/uvrC motif; Region: UVR; pfam02151 482957010719 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 482957010720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957010721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957010722 homodimer interface [polypeptide binding]; other site 482957010723 catalytic residue [active] 482957010724 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 482957010725 classical (c) SDRs; Region: SDR_c; cd05233 482957010726 NAD(P) binding site [chemical binding]; other site 482957010727 active site 482957010728 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 482957010729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957010730 active site 482957010731 catalytic tetrad [active] 482957010732 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 482957010733 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 482957010734 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 482957010735 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 482957010736 DNA binding residues [nucleotide binding] 482957010737 dimer interface [polypeptide binding]; other site 482957010738 copper binding site [ion binding]; other site 482957010739 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 482957010740 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957010741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 482957010742 active site 482957010743 phosphorylation site [posttranslational modification] 482957010744 dimerization interface [polypeptide binding]; other site 482957010745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957010746 DNA binding residues [nucleotide binding] 482957010747 Predicted membrane protein [Function unknown]; Region: COG3235 482957010748 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 482957010749 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 482957010750 putative active site [active] 482957010751 Zn binding site [ion binding]; other site 482957010752 hypothetical protein; Validated; Region: PRK02101 482957010753 PIN domain; Region: PIN_3; pfam13470 482957010754 methionine aminotransferase; Validated; Region: PRK09082 482957010755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957010756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957010757 homodimer interface [polypeptide binding]; other site 482957010758 catalytic residue [active] 482957010759 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957010760 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 482957010761 C-terminal domain interface [polypeptide binding]; other site 482957010762 GSH binding site (G-site) [chemical binding]; other site 482957010763 dimer interface [polypeptide binding]; other site 482957010764 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 482957010765 putative N-terminal domain interface [polypeptide binding]; other site 482957010766 putative dimer interface [polypeptide binding]; other site 482957010767 putative substrate binding pocket (H-site) [chemical binding]; other site 482957010768 enoyl-CoA hydratase; Provisional; Region: PRK07511 482957010769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957010770 substrate binding site [chemical binding]; other site 482957010771 oxyanion hole (OAH) forming residues; other site 482957010772 trimer interface [polypeptide binding]; other site 482957010773 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 482957010774 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 482957010775 C-terminal domain interface [polypeptide binding]; other site 482957010776 GSH binding site (G-site) [chemical binding]; other site 482957010777 dimer interface [polypeptide binding]; other site 482957010778 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 482957010779 N-terminal domain interface [polypeptide binding]; other site 482957010780 putative dimer interface [polypeptide binding]; other site 482957010781 active site 482957010782 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 482957010783 putative active site [active] 482957010784 putative catalytic site [active] 482957010785 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 482957010786 putative active site [active] 482957010787 putative catalytic site [active] 482957010788 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 482957010789 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957010790 active site 482957010791 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 482957010792 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 482957010793 FAD binding site [chemical binding]; other site 482957010794 substrate binding site [chemical binding]; other site 482957010795 catalytic base [active] 482957010796 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 482957010797 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 482957010798 dimer interface [polypeptide binding]; other site 482957010799 ADP-ribose binding site [chemical binding]; other site 482957010800 active site 482957010801 nudix motif; other site 482957010802 metal binding site [ion binding]; metal-binding site 482957010803 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 482957010804 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 482957010805 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 482957010806 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 482957010807 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 482957010808 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 482957010809 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 482957010810 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 482957010811 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 482957010812 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 482957010813 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 482957010814 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 482957010815 4Fe-4S binding domain; Region: Fer4; pfam00037 482957010816 4Fe-4S binding domain; Region: Fer4; pfam00037 482957010817 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 482957010818 NADH dehydrogenase subunit G; Validated; Region: PRK09129 482957010819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957010820 catalytic loop [active] 482957010821 iron binding site [ion binding]; other site 482957010822 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 482957010823 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 482957010824 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 482957010825 SLBB domain; Region: SLBB; pfam10531 482957010826 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 482957010827 NADH dehydrogenase subunit E; Validated; Region: PRK07539 482957010828 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 482957010829 putative dimer interface [polypeptide binding]; other site 482957010830 [2Fe-2S] cluster binding site [ion binding]; other site 482957010831 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 482957010832 NADH dehydrogenase subunit D; Validated; Region: PRK06075 482957010833 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 482957010834 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 482957010835 NADH dehydrogenase subunit B; Validated; Region: PRK06411 482957010836 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 482957010837 Preprotein translocase SecG subunit; Region: SecG; pfam03840 482957010838 triosephosphate isomerase; Provisional; Region: PRK14567 482957010839 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 482957010840 substrate binding site [chemical binding]; other site 482957010841 dimer interface [polypeptide binding]; other site 482957010842 catalytic triad [active] 482957010843 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 482957010844 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 482957010845 NAD(P) binding site [chemical binding]; other site 482957010846 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 482957010847 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 482957010848 RNase E interface [polypeptide binding]; other site 482957010849 trimer interface [polypeptide binding]; other site 482957010850 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 482957010851 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 482957010852 RNase E interface [polypeptide binding]; other site 482957010853 trimer interface [polypeptide binding]; other site 482957010854 active site 482957010855 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 482957010856 putative nucleic acid binding region [nucleotide binding]; other site 482957010857 G-X-X-G motif; other site 482957010858 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 482957010859 RNA binding site [nucleotide binding]; other site 482957010860 domain interface; other site 482957010861 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 482957010862 16S/18S rRNA binding site [nucleotide binding]; other site 482957010863 S13e-L30e interaction site [polypeptide binding]; other site 482957010864 25S rRNA binding site [nucleotide binding]; other site 482957010865 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 482957010866 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 482957010867 putative ligand binding site [chemical binding]; other site 482957010868 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 482957010869 active site clefts [active] 482957010870 zinc binding site [ion binding]; other site 482957010871 dimer interface [polypeptide binding]; other site 482957010872 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 482957010873 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 482957010874 Sulfate transporter family; Region: Sulfate_transp; pfam00916 482957010875 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 482957010876 2-isopropylmalate synthase; Validated; Region: PRK00915 482957010877 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 482957010878 active site 482957010879 catalytic residues [active] 482957010880 metal binding site [ion binding]; metal-binding site 482957010881 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 482957010882 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 482957010883 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 482957010884 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 482957010885 ketol-acid reductoisomerase; Provisional; Region: PRK05479 482957010886 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 482957010887 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 482957010888 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 482957010889 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 482957010890 putative valine binding site [chemical binding]; other site 482957010891 dimer interface [polypeptide binding]; other site 482957010892 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 482957010893 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 482957010894 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957010895 PYR/PP interface [polypeptide binding]; other site 482957010896 dimer interface [polypeptide binding]; other site 482957010897 TPP binding site [chemical binding]; other site 482957010898 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957010899 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 482957010900 TPP-binding site [chemical binding]; other site 482957010901 dimer interface [polypeptide binding]; other site 482957010902 RNA polymerase factor sigma-70; Validated; Region: PRK09047 482957010903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957010904 DNA binding residues [nucleotide binding] 482957010905 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 482957010906 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 482957010907 RDD family; Region: RDD; pfam06271 482957010908 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 482957010909 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 482957010910 putative active site [active] 482957010911 putative metal binding site [ion binding]; other site 482957010912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957010913 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 482957010914 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 482957010915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957010916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957010917 Bacterial transcriptional repressor; Region: TetR; pfam13972 482957010918 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 482957010919 glucose-1-dehydrogenase; Provisional; Region: PRK06947 482957010920 classical (c) SDRs; Region: SDR_c; cd05233 482957010921 NAD(P) binding site [chemical binding]; other site 482957010922 active site 482957010923 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 482957010924 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 482957010925 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 482957010926 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 482957010927 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 482957010928 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 482957010929 apolar tunnel; other site 482957010930 heme binding site [chemical binding]; other site 482957010931 dimerization interface [polypeptide binding]; other site 482957010932 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 482957010933 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 482957010934 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 482957010935 multidrug efflux system protein; Provisional; Region: PRK11431 482957010936 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 482957010937 Domain of unknown function (DUF333); Region: DUF333; pfam03891 482957010938 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 482957010939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957010940 active site 482957010941 phosphorylation site [posttranslational modification] 482957010942 intermolecular recognition site; other site 482957010943 dimerization interface [polypeptide binding]; other site 482957010944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957010945 DNA binding site [nucleotide binding] 482957010946 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 482957010947 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 482957010948 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 482957010949 Ligand Binding Site [chemical binding]; other site 482957010950 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 482957010951 GAF domain; Region: GAF_3; pfam13492 482957010952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957010953 dimer interface [polypeptide binding]; other site 482957010954 phosphorylation site [posttranslational modification] 482957010955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957010956 ATP binding site [chemical binding]; other site 482957010957 Mg2+ binding site [ion binding]; other site 482957010958 G-X-G motif; other site 482957010959 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 482957010960 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 482957010961 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 482957010962 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 482957010963 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 482957010964 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 482957010965 NADP binding site [chemical binding]; other site 482957010966 dimer interface [polypeptide binding]; other site 482957010967 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 482957010968 active site 482957010969 dimer interfaces [polypeptide binding]; other site 482957010970 catalytic residues [active] 482957010971 short chain dehydrogenase; Provisional; Region: PRK08339 482957010972 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 482957010973 putative NAD(P) binding site [chemical binding]; other site 482957010974 putative active site [active] 482957010975 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957010976 active site 482957010977 hypothetical protein; Validated; Region: PRK00110 482957010978 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 482957010979 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 482957010980 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 482957010981 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 482957010982 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 482957010983 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 482957010984 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 482957010985 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 482957010986 active site 482957010987 (T/H)XGH motif; other site 482957010988 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 482957010989 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 482957010990 Maf-like protein; Region: Maf; pfam02545 482957010991 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 482957010992 active site 482957010993 dimer interface [polypeptide binding]; other site 482957010994 ribonuclease G; Provisional; Region: PRK11712 482957010995 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 482957010996 homodimer interface [polypeptide binding]; other site 482957010997 oligonucleotide binding site [chemical binding]; other site 482957010998 Helix-turn-helix domain; Region: HTH_17; pfam12728 482957010999 Phage T7 tail fibre protein; Region: Phage_T7_tail; pfam03906 482957011000 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 482957011001 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 482957011002 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 482957011003 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 482957011004 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 482957011005 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 482957011006 Virulence-associated protein E; Region: VirE; pfam05272 482957011007 integrase; Provisional; Region: PRK09692 482957011008 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957011009 active site 482957011010 DNA binding site [nucleotide binding] 482957011011 Int/Topo IB signature motif; other site 482957011012 Protein with unknown function (DUF469); Region: DUF469; pfam04320 482957011013 PRC-barrel domain; Region: PRC; pfam05239 482957011014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957011015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957011016 putative substrate translocation pore; other site 482957011017 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 482957011018 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 482957011019 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957011020 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 482957011021 Walker A/P-loop; other site 482957011022 ATP binding site [chemical binding]; other site 482957011023 Q-loop/lid; other site 482957011024 ABC transporter signature motif; other site 482957011025 Walker B; other site 482957011026 D-loop; other site 482957011027 H-loop/switch region; other site 482957011028 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 482957011029 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 482957011030 putative metal binding site; other site 482957011031 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 482957011032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 482957011033 active site 482957011034 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 482957011035 O-Antigen ligase; Region: Wzy_C; pfam04932 482957011036 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 482957011037 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 482957011038 putative active site [active] 482957011039 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 482957011040 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957011041 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957011042 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 482957011043 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 482957011044 putative active site [active] 482957011045 putative PHP Thumb interface [polypeptide binding]; other site 482957011046 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 482957011047 generic binding surface II; other site 482957011048 generic binding surface I; other site 482957011049 rhodanese superfamily protein; Provisional; Region: PRK05320 482957011050 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 482957011051 active site residue [active] 482957011052 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 482957011053 active site 482957011054 HIGH motif; other site 482957011055 nucleotide binding site [chemical binding]; other site 482957011056 active site 482957011057 KMSKS motif; other site 482957011058 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 482957011059 DEAD-like helicases superfamily; Region: DEXDc; smart00487 482957011060 ATP binding site [chemical binding]; other site 482957011061 Mg++ binding site [ion binding]; other site 482957011062 motif III; other site 482957011063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957011064 nucleotide binding region [chemical binding]; other site 482957011065 ATP-binding site [chemical binding]; other site 482957011066 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 482957011067 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 482957011068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957011069 ATP-grasp domain; Region: ATP-grasp; pfam02222 482957011070 META domain; Region: META; pfam03724 482957011071 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 482957011072 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 482957011073 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 482957011074 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 482957011075 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 482957011076 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 482957011077 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 482957011078 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 482957011079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957011080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957011081 ferredoxin; Provisional; Region: PRK06991 482957011082 Putative Fe-S cluster; Region: FeS; pfam04060 482957011083 4Fe-4S binding domain; Region: Fer4; pfam00037 482957011084 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 482957011085 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 482957011086 minor groove reading motif; other site 482957011087 helix-hairpin-helix signature motif; other site 482957011088 substrate binding pocket [chemical binding]; other site 482957011089 active site 482957011090 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 482957011091 EamA-like transporter family; Region: EamA; pfam00892 482957011092 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 482957011093 EamA-like transporter family; Region: EamA; pfam00892 482957011094 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 482957011095 Cytochrome c553 [Energy production and conversion]; Region: COG2863 482957011096 Cytochrome c553 [Energy production and conversion]; Region: COG2863 482957011097 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 482957011098 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957011099 Walker A motif; other site 482957011100 ATP binding site [chemical binding]; other site 482957011101 Walker B motif; other site 482957011102 arginine finger; other site 482957011103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 482957011104 Benzoate membrane transport protein; Region: BenE; pfam03594 482957011105 benzoate transporter; Region: benE; TIGR00843 482957011106 transaldolase-like protein; Provisional; Region: PTZ00411 482957011107 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 482957011108 active site 482957011109 dimer interface [polypeptide binding]; other site 482957011110 catalytic residue [active] 482957011111 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 482957011112 dimer interface [polypeptide binding]; other site 482957011113 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957011114 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 482957011115 Na binding site [ion binding]; other site 482957011116 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 482957011117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 482957011118 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 482957011119 putative active site [active] 482957011120 Chorismate lyase; Region: Chor_lyase; cl01230 482957011121 heat shock protein 90; Provisional; Region: PRK05218 482957011122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957011123 ATP binding site [chemical binding]; other site 482957011124 Mg2+ binding site [ion binding]; other site 482957011125 G-X-G motif; other site 482957011126 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957011127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957011128 DNA-binding site [nucleotide binding]; DNA binding site 482957011129 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957011130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957011131 homodimer interface [polypeptide binding]; other site 482957011132 catalytic residue [active] 482957011133 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 482957011134 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957011135 EamA-like transporter family; Region: EamA; pfam00892 482957011136 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 482957011137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957011138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957011139 homodimer interface [polypeptide binding]; other site 482957011140 catalytic residue [active] 482957011141 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 482957011142 homotrimer interaction site [polypeptide binding]; other site 482957011143 putative active site [active] 482957011144 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 482957011145 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 482957011146 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957011147 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957011148 metal binding site [ion binding]; metal-binding site 482957011149 active site 482957011150 I-site; other site 482957011151 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957011152 Chromate transporter; Region: Chromate_transp; pfam02417 482957011153 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 482957011154 Chromate transporter; Region: Chromate_transp; pfam02417 482957011155 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 482957011156 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 482957011157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957011158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957011160 dimerization interface [polypeptide binding]; other site 482957011161 Predicted integral membrane protein [Function unknown]; Region: COG5615 482957011162 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 482957011163 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 482957011164 CAP-like domain; other site 482957011165 active site 482957011166 primary dimer interface [polypeptide binding]; other site 482957011167 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 482957011168 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 482957011169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957011170 ATP binding site [chemical binding]; other site 482957011171 Mg2+ binding site [ion binding]; other site 482957011172 G-X-G motif; other site 482957011173 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 482957011174 anchoring element; other site 482957011175 dimer interface [polypeptide binding]; other site 482957011176 ATP binding site [chemical binding]; other site 482957011177 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 482957011178 active site 482957011179 metal binding site [ion binding]; metal-binding site 482957011180 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 482957011181 ABC transporter ATPase component; Reviewed; Region: PRK11147 482957011182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957011183 Walker A/P-loop; other site 482957011184 ATP binding site [chemical binding]; other site 482957011185 Q-loop/lid; other site 482957011186 ABC transporter signature motif; other site 482957011187 Walker B; other site 482957011188 D-loop; other site 482957011189 H-loop/switch region; other site 482957011190 ABC transporter; Region: ABC_tran_2; pfam12848 482957011191 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957011192 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 482957011193 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 482957011194 Rubredoxin; Region: Rubredoxin; pfam00301 482957011195 iron binding site [ion binding]; other site 482957011196 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 482957011197 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 482957011198 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 482957011199 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 482957011200 Restriction endonuclease; Region: Mrr_cat; pfam04471 482957011201 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957011202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957011203 NAD(P) binding site [chemical binding]; other site 482957011204 active site 482957011205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957011206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957011207 ecotin; Provisional; Region: PRK03719 482957011208 secondary substrate binding site; other site 482957011209 primary substrate binding site; other site 482957011210 inhibition loop; other site 482957011211 dimerization interface [polypeptide binding]; other site 482957011212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957011213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957011214 putative substrate translocation pore; other site 482957011215 Predicted ATPase [General function prediction only]; Region: COG3911 482957011216 AAA domain; Region: AAA_28; pfam13521 482957011217 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 482957011218 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 482957011219 active site 482957011220 homotetramer interface [polypeptide binding]; other site 482957011221 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 482957011222 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957011223 Walker A/P-loop; other site 482957011224 ATP binding site [chemical binding]; other site 482957011225 Q-loop/lid; other site 482957011226 ABC transporter signature motif; other site 482957011227 Walker B; other site 482957011228 D-loop; other site 482957011229 H-loop/switch region; other site 482957011230 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 482957011231 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 482957011232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957011233 dimer interface [polypeptide binding]; other site 482957011234 conserved gate region; other site 482957011235 putative PBP binding loops; other site 482957011236 ABC-ATPase subunit interface; other site 482957011237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957011238 dimer interface [polypeptide binding]; other site 482957011239 conserved gate region; other site 482957011240 putative PBP binding loops; other site 482957011241 ABC-ATPase subunit interface; other site 482957011242 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 482957011243 HAMP domain; Region: HAMP; pfam00672 482957011244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957011245 dimer interface [polypeptide binding]; other site 482957011246 phosphorylation site [posttranslational modification] 482957011247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957011248 ATP binding site [chemical binding]; other site 482957011249 Mg2+ binding site [ion binding]; other site 482957011250 G-X-G motif; other site 482957011251 osmolarity response regulator; Provisional; Region: ompR; PRK09468 482957011252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957011253 active site 482957011254 phosphorylation site [posttranslational modification] 482957011255 intermolecular recognition site; other site 482957011256 dimerization interface [polypeptide binding]; other site 482957011257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957011258 DNA binding site [nucleotide binding] 482957011259 Heavy-metal resistance; Region: Metal_resist; pfam13801 482957011260 Pirin-related protein [General function prediction only]; Region: COG1741 482957011261 Pirin; Region: Pirin; pfam02678 482957011262 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 482957011263 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957011264 substrate binding pocket [chemical binding]; other site 482957011265 membrane-bound complex binding site; other site 482957011266 hinge residues; other site 482957011267 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957011268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957011269 dimer interface [polypeptide binding]; other site 482957011270 conserved gate region; other site 482957011271 putative PBP binding loops; other site 482957011272 ABC-ATPase subunit interface; other site 482957011273 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957011274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957011275 dimer interface [polypeptide binding]; other site 482957011276 conserved gate region; other site 482957011277 putative PBP binding loops; other site 482957011278 ABC-ATPase subunit interface; other site 482957011279 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 482957011280 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957011281 Walker A/P-loop; other site 482957011282 ATP binding site [chemical binding]; other site 482957011283 Q-loop/lid; other site 482957011284 ABC transporter signature motif; other site 482957011285 Walker B; other site 482957011286 D-loop; other site 482957011287 H-loop/switch region; other site 482957011288 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957011289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957011290 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 482957011291 putative substrate binding pocket [chemical binding]; other site 482957011292 dimerization interface [polypeptide binding]; other site 482957011293 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957011294 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957011295 trimer interface [polypeptide binding]; other site 482957011296 eyelet of channel; other site 482957011297 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 482957011298 Nitrogen regulatory protein P-II; Region: P-II; smart00938 482957011299 NAD synthetase; Provisional; Region: PRK13981 482957011300 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 482957011301 multimer interface [polypeptide binding]; other site 482957011302 active site 482957011303 catalytic triad [active] 482957011304 protein interface 1 [polypeptide binding]; other site 482957011305 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 482957011306 homodimer interface [polypeptide binding]; other site 482957011307 NAD binding pocket [chemical binding]; other site 482957011308 ATP binding pocket [chemical binding]; other site 482957011309 Mg binding site [ion binding]; other site 482957011310 active-site loop [active] 482957011311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 482957011312 Protein of unknown function, DUF482; Region: DUF482; pfam04339 482957011313 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957011314 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957011315 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 482957011316 GIY-YIG motif/motif A; other site 482957011317 putative active site [active] 482957011318 putative metal binding site [ion binding]; other site 482957011319 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 482957011320 dimer interface [polypeptide binding]; other site 482957011321 substrate binding site [chemical binding]; other site 482957011322 metal binding sites [ion binding]; metal-binding site 482957011323 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957011324 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 482957011325 NAD(P) binding site [chemical binding]; other site 482957011326 catalytic residues [active] 482957011327 catalytic residues [active] 482957011328 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 482957011329 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 482957011330 putative NAD(P) binding site [chemical binding]; other site 482957011331 active site 482957011332 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 482957011333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957011334 putative substrate translocation pore; other site 482957011335 Helix-turn-helix domain; Region: HTH_17; pfam12728 482957011336 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957011337 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 482957011338 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 482957011339 HemY protein N-terminus; Region: HemY_N; pfam07219 482957011340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957011341 TPR motif; other site 482957011342 binding surface 482957011343 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 482957011344 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 482957011345 active site 482957011346 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 482957011347 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 482957011348 domain interfaces; other site 482957011349 active site 482957011350 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 482957011351 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 482957011352 Methyltransferase domain; Region: Methyltransf_31; pfam13847 482957011353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957011354 S-adenosylmethionine binding site [chemical binding]; other site 482957011355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957011356 non-specific DNA binding site [nucleotide binding]; other site 482957011357 salt bridge; other site 482957011358 sequence-specific DNA binding site [nucleotide binding]; other site 482957011359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957011360 Spore Coat Protein U domain; Region: SCPU; pfam05229 482957011361 Spore Coat Protein U domain; Region: SCPU; pfam05229 482957011362 Spore Coat Protein U domain; Region: SCPU; pfam05229 482957011363 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 482957011364 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 482957011365 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 482957011366 PapC N-terminal domain; Region: PapC_N; pfam13954 482957011367 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 482957011368 PapC C-terminal domain; Region: PapC_C; pfam13953 482957011369 argininosuccinate lyase; Provisional; Region: PRK00855 482957011370 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 482957011371 active sites [active] 482957011372 tetramer interface [polypeptide binding]; other site 482957011373 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 482957011374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957011375 motif II; other site 482957011376 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 482957011377 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 482957011378 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 482957011379 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 482957011380 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957011381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957011382 catalytic residue [active] 482957011383 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 482957011384 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 482957011385 trimer interface [polypeptide binding]; other site 482957011386 active site 482957011387 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 482957011388 E-class dimer interface [polypeptide binding]; other site 482957011389 P-class dimer interface [polypeptide binding]; other site 482957011390 active site 482957011391 Cu2+ binding site [ion binding]; other site 482957011392 Zn2+ binding site [ion binding]; other site 482957011393 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 482957011394 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 482957011395 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957011396 ligand binding site [chemical binding]; other site 482957011397 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 482957011398 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 482957011399 active site 482957011400 HIGH motif; other site 482957011401 KMSKS motif; other site 482957011402 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 482957011403 tRNA binding surface [nucleotide binding]; other site 482957011404 anticodon binding site; other site 482957011405 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 482957011406 dimer interface [polypeptide binding]; other site 482957011407 putative tRNA-binding site [nucleotide binding]; other site 482957011408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 482957011409 Family of unknown function (DUF490); Region: DUF490; pfam04357 482957011410 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 482957011411 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 482957011412 Surface antigen; Region: Bac_surface_Ag; pfam01103 482957011413 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 482957011414 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 482957011415 pantoate--beta-alanine ligase; Region: panC; TIGR00018 482957011416 Pantoate-beta-alanine ligase; Region: PanC; cd00560 482957011417 active site 482957011418 ATP-binding site [chemical binding]; other site 482957011419 pantoate-binding site; other site 482957011420 HXXH motif; other site 482957011421 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 482957011422 tetramerization interface [polypeptide binding]; other site 482957011423 active site 482957011424 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 482957011425 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957011426 P-loop; other site 482957011427 Magnesium ion binding site [ion binding]; other site 482957011428 DoxX; Region: DoxX; pfam07681 482957011429 cobyric acid synthase; Provisional; Region: PRK00784 482957011430 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 482957011431 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 482957011432 catalytic triad [active] 482957011433 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 482957011434 homotrimer interface [polypeptide binding]; other site 482957011435 Walker A motif; other site 482957011436 GTP binding site [chemical binding]; other site 482957011437 Walker B motif; other site 482957011438 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 482957011439 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 482957011440 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 482957011441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957011442 catalytic residue [active] 482957011443 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 482957011444 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 482957011445 cobalamin binding residues [chemical binding]; other site 482957011446 putative BtuC binding residues; other site 482957011447 dimer interface [polypeptide binding]; other site 482957011448 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 482957011449 catalytic core [active] 482957011450 cobalamin synthase; Reviewed; Region: cobS; PRK00235 482957011451 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 482957011452 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 482957011453 putative dimer interface [polypeptide binding]; other site 482957011454 active site pocket [active] 482957011455 putative cataytic base [active] 482957011456 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 482957011457 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 482957011458 Walker A/P-loop; other site 482957011459 ATP binding site [chemical binding]; other site 482957011460 Q-loop/lid; other site 482957011461 ABC transporter signature motif; other site 482957011462 Walker B; other site 482957011463 D-loop; other site 482957011464 H-loop/switch region; other site 482957011465 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 482957011466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 482957011467 ABC-ATPase subunit interface; other site 482957011468 dimer interface [polypeptide binding]; other site 482957011469 putative PBP binding regions; other site 482957011470 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 482957011471 Cell division protein ZapA; Region: ZapA; pfam05164 482957011472 EVE domain; Region: EVE; cl00728 482957011473 Protein of unknown function (DUF541); Region: SIMPL; cl01077 482957011474 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 482957011475 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 482957011476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011477 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 482957011478 putative dimerization interface [polypeptide binding]; other site 482957011479 putative substrate binding pocket [chemical binding]; other site 482957011480 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 482957011481 Cytochrome c; Region: Cytochrom_C; cl11414 482957011482 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 482957011483 DNA polymerase III subunit chi; Validated; Region: PRK05728 482957011484 multifunctional aminopeptidase A; Provisional; Region: PRK00913 482957011485 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 482957011486 interface (dimer of trimers) [polypeptide binding]; other site 482957011487 Substrate-binding/catalytic site; other site 482957011488 Zn-binding sites [ion binding]; other site 482957011489 Predicted permeases [General function prediction only]; Region: COG0795 482957011490 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 482957011491 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 482957011492 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 482957011493 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 482957011494 putative active site [active] 482957011495 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 482957011496 active site 482957011497 SAM binding site [chemical binding]; other site 482957011498 homodimer interface [polypeptide binding]; other site 482957011499 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 482957011500 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 482957011501 CysD dimerization site [polypeptide binding]; other site 482957011502 G1 box; other site 482957011503 putative GEF interaction site [polypeptide binding]; other site 482957011504 GTP/Mg2+ binding site [chemical binding]; other site 482957011505 Switch I region; other site 482957011506 G2 box; other site 482957011507 G3 box; other site 482957011508 Switch II region; other site 482957011509 G4 box; other site 482957011510 G5 box; other site 482957011511 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 482957011512 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 482957011513 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 482957011514 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 482957011515 Active Sites [active] 482957011516 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 482957011517 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 482957011518 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 482957011519 Active Sites [active] 482957011520 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 482957011521 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 482957011522 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 482957011523 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 482957011524 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 482957011525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011526 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 482957011527 substrate binding site [chemical binding]; other site 482957011528 dimerization interface [polypeptide binding]; other site 482957011529 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957011530 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 482957011531 putative ligand binding site [chemical binding]; other site 482957011532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957011533 binding surface 482957011534 TPR motif; other site 482957011535 TPR repeat; Region: TPR_11; pfam13414 482957011536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957011537 binding surface 482957011538 TPR motif; other site 482957011539 TPR repeat; Region: TPR_11; pfam13414 482957011540 TPR repeat; Region: TPR_11; pfam13414 482957011541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957011542 binding surface 482957011543 TPR motif; other site 482957011544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957011545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011546 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957011547 putative effector binding pocket; other site 482957011548 dimerization interface [polypeptide binding]; other site 482957011549 short chain dehydrogenase; Provisional; Region: PRK12937 482957011550 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 482957011551 NADP binding site [chemical binding]; other site 482957011552 homodimer interface [polypeptide binding]; other site 482957011553 active site 482957011554 substrate binding site [chemical binding]; other site 482957011555 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957011556 NADP binding site [chemical binding]; other site 482957011557 active site 482957011558 steroid binding site; other site 482957011559 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957011560 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957011561 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957011563 dimerization interface [polypeptide binding]; other site 482957011564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957011565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011566 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957011567 putative effector binding pocket; other site 482957011568 putative dimerization interface [polypeptide binding]; other site 482957011569 short chain dehydrogenase; Provisional; Region: PRK12744 482957011570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957011571 NAD(P) binding site [chemical binding]; other site 482957011572 active site 482957011573 DinB superfamily; Region: DinB_2; pfam12867 482957011574 CopC domain; Region: CopC; pfam04234 482957011575 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 482957011576 RNA binding surface [nucleotide binding]; other site 482957011577 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 482957011578 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 482957011579 active site 482957011580 uracil binding [chemical binding]; other site 482957011581 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957011582 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 482957011583 putative NAD(P) binding site [chemical binding]; other site 482957011584 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 482957011585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957011586 catalytic loop [active] 482957011587 iron binding site [ion binding]; other site 482957011588 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 482957011589 FAD binding pocket [chemical binding]; other site 482957011590 FAD binding motif [chemical binding]; other site 482957011591 phosphate binding motif [ion binding]; other site 482957011592 beta-alpha-beta structure motif; other site 482957011593 NAD binding pocket [chemical binding]; other site 482957011594 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 482957011595 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957011596 inhibitor-cofactor binding pocket; inhibition site 482957011597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957011598 catalytic residue [active] 482957011599 putative acetyltransferase; Provisional; Region: PRK03624 482957011600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957011601 Coenzyme A binding pocket [chemical binding]; other site 482957011602 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 482957011603 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 482957011604 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957011605 Walker A/P-loop; other site 482957011606 ATP binding site [chemical binding]; other site 482957011607 Q-loop/lid; other site 482957011608 ABC transporter signature motif; other site 482957011609 Walker B; other site 482957011610 D-loop; other site 482957011611 H-loop/switch region; other site 482957011612 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 482957011613 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957011614 Walker A/P-loop; other site 482957011615 ATP binding site [chemical binding]; other site 482957011616 Q-loop/lid; other site 482957011617 ABC transporter signature motif; other site 482957011618 Walker B; other site 482957011619 D-loop; other site 482957011620 H-loop/switch region; other site 482957011621 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957011622 TM-ABC transporter signature motif; other site 482957011623 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957011624 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957011625 TM-ABC transporter signature motif; other site 482957011626 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 482957011627 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 482957011628 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 482957011629 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 482957011630 hypothetical protein; Reviewed; Region: PRK00024 482957011631 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 482957011632 MPN+ (JAMM) motif; other site 482957011633 Zinc-binding site [ion binding]; other site 482957011634 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 482957011635 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 482957011636 L-aspartate oxidase; Provisional; Region: PRK09077 482957011637 L-aspartate oxidase; Provisional; Region: PRK06175 482957011638 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 482957011639 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 482957011640 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 482957011641 dimerization interface [polypeptide binding]; other site 482957011642 active site 482957011643 quinolinate synthetase; Provisional; Region: PRK09375 482957011644 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 482957011645 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957011646 Di-iron ligands [ion binding]; other site 482957011647 Transposase; Region: DDE_Tnp_ISL3; pfam01610 482957011648 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 482957011649 Mechanosensitive ion channel; Region: MS_channel; pfam00924 482957011650 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 482957011651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957011652 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 482957011653 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 482957011654 active site 482957011655 substrate binding site [chemical binding]; other site 482957011656 cosubstrate binding site; other site 482957011657 catalytic site [active] 482957011658 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 482957011659 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 482957011660 active site 482957011661 Riboflavin kinase; Region: Flavokinase; smart00904 482957011662 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 482957011663 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957011664 active site 482957011665 HIGH motif; other site 482957011666 nucleotide binding site [chemical binding]; other site 482957011667 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 482957011668 active site 482957011669 KMSKS motif; other site 482957011670 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 482957011671 tRNA binding surface [nucleotide binding]; other site 482957011672 anticodon binding site; other site 482957011673 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 482957011674 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 482957011675 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 482957011676 Flavoprotein; Region: Flavoprotein; pfam02441 482957011677 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 482957011678 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 482957011679 trimer interface [polypeptide binding]; other site 482957011680 active site 482957011681 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 482957011682 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 482957011683 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 482957011684 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 482957011685 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 482957011686 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 482957011687 Clp amino terminal domain; Region: Clp_N; pfam02861 482957011688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957011689 Walker A motif; other site 482957011690 ATP binding site [chemical binding]; other site 482957011691 Walker B motif; other site 482957011692 arginine finger; other site 482957011693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957011694 Walker A motif; other site 482957011695 ATP binding site [chemical binding]; other site 482957011696 Walker B motif; other site 482957011697 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 482957011698 Uncharacterized conserved protein [Function unknown]; Region: COG2127 482957011699 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 482957011700 DNA-binding site [nucleotide binding]; DNA binding site 482957011701 RNA-binding motif; other site 482957011702 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 482957011703 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 482957011704 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 482957011705 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 482957011706 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 482957011707 isocitrate dehydrogenase; Validated; Region: PRK07362 482957011708 isocitrate dehydrogenase; Reviewed; Region: PRK07006 482957011709 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 482957011710 pseudouridine synthase; Region: TIGR00093 482957011711 active site 482957011712 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 482957011713 elongation factor G; Reviewed; Region: PRK00007 482957011714 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 482957011715 G1 box; other site 482957011716 putative GEF interaction site [polypeptide binding]; other site 482957011717 GTP/Mg2+ binding site [chemical binding]; other site 482957011718 Switch I region; other site 482957011719 G2 box; other site 482957011720 G3 box; other site 482957011721 Switch II region; other site 482957011722 G4 box; other site 482957011723 G5 box; other site 482957011724 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 482957011725 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 482957011726 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 482957011727 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 482957011728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957011729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957011730 active site 482957011731 catalytic tetrad [active] 482957011732 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 482957011733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957011734 DNA-binding site [nucleotide binding]; DNA binding site 482957011735 UTRA domain; Region: UTRA; pfam07702 482957011736 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957011737 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957011738 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 482957011739 putative transporter; Provisional; Region: PRK10504 482957011740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957011741 putative substrate translocation pore; other site 482957011742 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957011743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 482957011744 S-adenosylmethionine binding site [chemical binding]; other site 482957011745 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 482957011746 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 482957011747 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 482957011748 Protein of unknown function (DUF962); Region: DUF962; cl01879 482957011749 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 482957011750 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957011751 ligand binding site [chemical binding]; other site 482957011752 flexible hinge region; other site 482957011753 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 482957011754 putative switch regulator; other site 482957011755 non-specific DNA interactions [nucleotide binding]; other site 482957011756 DNA binding site [nucleotide binding] 482957011757 sequence specific DNA binding site [nucleotide binding]; other site 482957011758 putative cAMP binding site [chemical binding]; other site 482957011759 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 482957011760 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 482957011761 Chromate transporter; Region: Chromate_transp; pfam02417 482957011762 superoxide dismutase; Provisional; Region: PRK10543 482957011763 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 482957011764 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 482957011765 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 482957011766 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 482957011767 generic binding surface II; other site 482957011768 generic binding surface I; other site 482957011769 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 482957011770 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 482957011771 Uncharacterized conserved protein [Function unknown]; Region: COG2835 482957011772 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 482957011773 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 482957011774 Ligand binding site; other site 482957011775 oligomer interface; other site 482957011776 adenylate kinase; Reviewed; Region: adk; PRK00279 482957011777 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 482957011778 AMP-binding site [chemical binding]; other site 482957011779 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 482957011780 short chain dehydrogenase; Provisional; Region: PRK07060 482957011781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957011782 NAD(P) binding site [chemical binding]; other site 482957011783 active site 482957011784 Uncharacterized conserved protein [Function unknown]; Region: COG2912 482957011785 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 482957011786 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 482957011787 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 482957011788 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 482957011789 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 482957011790 ornithine carbamoyltransferase; Provisional; Region: PRK00779 482957011791 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 482957011792 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 482957011793 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 482957011794 FAD binding domain; Region: FAD_binding_4; pfam01565 482957011795 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 482957011796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 482957011797 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 482957011798 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 482957011799 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 482957011800 putative deacylase active site [active] 482957011801 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 482957011802 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957011803 acyl-activating enzyme (AAE) consensus motif; other site 482957011804 AMP binding site [chemical binding]; other site 482957011805 active site 482957011806 CoA binding site [chemical binding]; other site 482957011807 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 482957011808 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 482957011809 active site 482957011810 Int/Topo IB signature motif; other site 482957011811 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 482957011812 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 482957011813 DNA binding site [nucleotide binding] 482957011814 active site 482957011815 epoxyqueuosine reductase; Region: TIGR00276 482957011816 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 482957011817 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 482957011818 AMIN domain; Region: AMIN; pfam11741 482957011819 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 482957011820 active site 482957011821 metal binding site [ion binding]; metal-binding site 482957011822 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 482957011823 EamA-like transporter family; Region: EamA; pfam00892 482957011824 EamA-like transporter family; Region: EamA; pfam00892 482957011825 Pirin-related protein [General function prediction only]; Region: COG1741 482957011826 Pirin; Region: Pirin; pfam02678 482957011827 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 482957011828 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 482957011829 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 482957011830 catalytic residues [active] 482957011831 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 482957011832 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 482957011833 putative ATP binding site [chemical binding]; other site 482957011834 putative substrate interface [chemical binding]; other site 482957011835 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 482957011836 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 482957011837 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 482957011838 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 482957011839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957011840 S-adenosylmethionine binding site [chemical binding]; other site 482957011841 Protein of unknown function DUF72; Region: DUF72; pfam01904 482957011842 methionine sulfoxide reductase A; Provisional; Region: PRK14054 482957011843 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 482957011844 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 482957011845 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957011846 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957011847 putative DNA binding site [nucleotide binding]; other site 482957011848 putative Zn2+ binding site [ion binding]; other site 482957011849 AsnC family; Region: AsnC_trans_reg; pfam01037 482957011850 arylformamidase; Region: trp_arylform; TIGR03035 482957011851 kynureninase; Region: kynureninase; TIGR01814 482957011852 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 482957011853 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957011854 catalytic residue [active] 482957011855 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 482957011856 benzoate transport; Region: 2A0115; TIGR00895 482957011857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957011858 putative substrate translocation pore; other site 482957011859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957011860 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 482957011861 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 482957011862 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 482957011863 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 482957011864 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 482957011865 NAD(P) binding site [chemical binding]; other site 482957011866 catalytic residues [active] 482957011867 benzoylformate decarboxylase; Reviewed; Region: PRK07092 482957011868 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957011869 PYR/PP interface [polypeptide binding]; other site 482957011870 dimer interface [polypeptide binding]; other site 482957011871 TPP binding site [chemical binding]; other site 482957011872 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957011873 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 482957011874 TPP-binding site [chemical binding]; other site 482957011875 dimer interface [polypeptide binding]; other site 482957011876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957011877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011878 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 482957011879 putative dimerization interface [polypeptide binding]; other site 482957011880 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 482957011881 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 482957011882 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 482957011883 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 482957011884 N- and C-terminal domain interface [polypeptide binding]; other site 482957011885 D-xylulose kinase; Region: XylB; TIGR01312 482957011886 active site 482957011887 MgATP binding site [chemical binding]; other site 482957011888 catalytic site [active] 482957011889 metal binding site [ion binding]; metal-binding site 482957011890 xylulose binding site [chemical binding]; other site 482957011891 homodimer interface [polypeptide binding]; other site 482957011892 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 482957011893 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 482957011894 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957011895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957011896 putative substrate translocation pore; other site 482957011897 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957011898 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957011899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957011900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957011901 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 482957011902 putative effector binding pocket; other site 482957011903 putative dimerization interface [polypeptide binding]; other site 482957011904 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 482957011905 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 482957011906 Walker A/P-loop; other site 482957011907 ATP binding site [chemical binding]; other site 482957011908 Q-loop/lid; other site 482957011909 ABC transporter signature motif; other site 482957011910 Walker B; other site 482957011911 D-loop; other site 482957011912 H-loop/switch region; other site 482957011913 TOBE domain; Region: TOBE; pfam03459 482957011914 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 482957011915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957011916 motif II; other site 482957011917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 482957011918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957011919 dimer interface [polypeptide binding]; other site 482957011920 conserved gate region; other site 482957011921 putative PBP binding loops; other site 482957011922 ABC-ATPase subunit interface; other site 482957011923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957011924 dimer interface [polypeptide binding]; other site 482957011925 conserved gate region; other site 482957011926 putative PBP binding loops; other site 482957011927 ABC-ATPase subunit interface; other site 482957011928 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 482957011929 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957011930 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 482957011931 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 482957011932 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957011933 substrate binding site [chemical binding]; other site 482957011934 ATP binding site [chemical binding]; other site 482957011935 sorbitol dehydrogenase; Provisional; Region: PRK07067 482957011936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957011937 NAD(P) binding site [chemical binding]; other site 482957011938 active site 482957011939 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 482957011940 metal binding site 2 [ion binding]; metal-binding site 482957011941 putative DNA binding helix; other site 482957011942 metal binding site 1 [ion binding]; metal-binding site 482957011943 dimer interface [polypeptide binding]; other site 482957011944 structural Zn2+ binding site [ion binding]; other site 482957011945 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 482957011946 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 482957011947 metal binding site [ion binding]; metal-binding site 482957011948 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 482957011949 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 482957011950 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 482957011951 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 482957011952 ABC-ATPase subunit interface; other site 482957011953 dimer interface [polypeptide binding]; other site 482957011954 S-formylglutathione hydrolase; Region: PLN02442 482957011955 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 482957011956 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 482957011957 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 482957011958 substrate binding site [chemical binding]; other site 482957011959 catalytic Zn binding site [ion binding]; other site 482957011960 NAD binding site [chemical binding]; other site 482957011961 structural Zn binding site [ion binding]; other site 482957011962 dimer interface [polypeptide binding]; other site 482957011963 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 482957011964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 482957011965 nucleotide binding site [chemical binding]; other site 482957011966 xanthine permease; Region: pbuX; TIGR03173 482957011967 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 482957011968 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 482957011969 Protein export membrane protein; Region: SecD_SecF; cl14618 482957011970 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 482957011971 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 482957011972 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957011973 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957011974 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 482957011975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957011976 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 482957011977 Isochorismatase family; Region: Isochorismatase; pfam00857 482957011978 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 482957011979 catalytic triad [active] 482957011980 conserved cis-peptide bond; other site 482957011981 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 482957011982 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957011983 conserved cys residue [active] 482957011984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957011985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957011986 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 482957011987 hydrophobic ligand binding site; other site 482957011988 Domain of unknown function (DUF427); Region: DUF427; pfam04248 482957011989 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 482957011990 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 482957011991 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 482957011992 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957011993 protein binding site [polypeptide binding]; other site 482957011994 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957011995 protein binding site [polypeptide binding]; other site 482957011996 sensor protein QseC; Provisional; Region: PRK10337 482957011997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957011998 dimer interface [polypeptide binding]; other site 482957011999 phosphorylation site [posttranslational modification] 482957012000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957012001 ATP binding site [chemical binding]; other site 482957012002 Mg2+ binding site [ion binding]; other site 482957012003 G-X-G motif; other site 482957012004 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 482957012005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957012006 active site 482957012007 phosphorylation site [posttranslational modification] 482957012008 intermolecular recognition site; other site 482957012009 dimerization interface [polypeptide binding]; other site 482957012010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957012011 DNA binding site [nucleotide binding] 482957012012 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 482957012013 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 482957012014 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 482957012015 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 482957012016 active site 482957012017 catalytic triad [active] 482957012018 oxyanion hole [active] 482957012019 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 482957012020 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 482957012021 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 482957012022 ATP-grasp domain; Region: ATP-grasp; pfam02222 482957012023 AIR carboxylase; Region: AIRC; pfam00731 482957012024 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 482957012025 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 482957012026 ATP binding site [chemical binding]; other site 482957012027 active site 482957012028 substrate binding site [chemical binding]; other site 482957012029 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 482957012030 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 482957012031 intersubunit interface [polypeptide binding]; other site 482957012032 active site 482957012033 zinc binding site [ion binding]; other site 482957012034 Na+ binding site [ion binding]; other site 482957012035 pyruvate kinase; Provisional; Region: PRK05826 482957012036 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 482957012037 domain interfaces; other site 482957012038 active site 482957012039 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 482957012040 Phosphoglycerate kinase; Region: PGK; pfam00162 482957012041 substrate binding site [chemical binding]; other site 482957012042 hinge regions; other site 482957012043 ADP binding site [chemical binding]; other site 482957012044 catalytic site [active] 482957012045 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 482957012046 AzlC protein; Region: AzlC; pfam03591 482957012047 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 482957012048 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 482957012049 homodimer interface [polypeptide binding]; other site 482957012050 substrate-cofactor binding pocket; other site 482957012051 catalytic residue [active] 482957012052 Zinc-finger domain; Region: zf-CHCC; cl01821 482957012053 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 482957012054 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 482957012055 putative active site [active] 482957012056 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 482957012057 SnoaL-like domain; Region: SnoaL_3; pfam13474 482957012058 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 482957012059 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 482957012060 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 482957012061 Peptidase family M48; Region: Peptidase_M48; pfam01435 482957012062 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 482957012063 trimer interface [polypeptide binding]; other site 482957012064 dimer interface [polypeptide binding]; other site 482957012065 putative active site [active] 482957012066 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 482957012067 O-Antigen ligase; Region: Wzy_C; pfam04932 482957012068 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 482957012069 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 482957012070 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 482957012071 Pilin (bacterial filament); Region: Pilin; pfam00114 482957012072 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 482957012073 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 482957012074 CoA binding domain; Region: CoA_binding; smart00881 482957012075 CoA-ligase; Region: Ligase_CoA; pfam00549 482957012076 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 482957012077 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 482957012078 CoA-ligase; Region: Ligase_CoA; pfam00549 482957012079 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 482957012080 recombination regulator RecX; Provisional; Region: recX; PRK14136 482957012081 recombinase A; Provisional; Region: recA; PRK09354 482957012082 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 482957012083 hexamer interface [polypeptide binding]; other site 482957012084 Walker A motif; other site 482957012085 ATP binding site [chemical binding]; other site 482957012086 Walker B motif; other site 482957012087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957012088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957012089 active site 482957012090 phosphorylation site [posttranslational modification] 482957012091 intermolecular recognition site; other site 482957012092 dimerization interface [polypeptide binding]; other site 482957012093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957012094 DNA binding site [nucleotide binding] 482957012095 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 482957012096 HAMP domain; Region: HAMP; pfam00672 482957012097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957012098 dimer interface [polypeptide binding]; other site 482957012099 phosphorylation site [posttranslational modification] 482957012100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957012101 ATP binding site [chemical binding]; other site 482957012102 Mg2+ binding site [ion binding]; other site 482957012103 G-X-G motif; other site 482957012104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957012105 putative substrate translocation pore; other site 482957012106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957012107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957012108 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957012109 putative effector binding pocket; other site 482957012110 putative dimerization interface [polypeptide binding]; other site 482957012111 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957012112 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957012113 conserved cys residue [active] 482957012114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957012115 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 482957012116 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 482957012117 conserved cys residue [active] 482957012118 Cupin domain; Region: Cupin_2; cl17218 482957012119 PAAR motif; Region: PAAR_motif; pfam05488 482957012120 MAPEG family; Region: MAPEG; pfam01124 482957012121 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 482957012122 Transglycosylase; Region: Transgly; cl17702 482957012123 Uncharacterized conserved protein [Function unknown]; Region: COG3791 482957012124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 482957012125 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 482957012126 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957012127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957012128 DNA-binding site [nucleotide binding]; DNA binding site 482957012129 FCD domain; Region: FCD; pfam07729 482957012130 galactonate dehydratase; Provisional; Region: PRK14017 482957012131 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 482957012132 putative active site pocket [active] 482957012133 putative metal binding site [ion binding]; other site 482957012134 Copper resistance protein D; Region: CopD; pfam05425 482957012135 Cytochrome c; Region: Cytochrom_C; cl11414 482957012136 Cytochrome c; Region: Cytochrom_C; cl11414 482957012137 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957012138 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957012139 Cytochrome c; Region: Cytochrom_C; pfam00034 482957012140 helicase 45; Provisional; Region: PTZ00424 482957012141 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 482957012142 ATP binding site [chemical binding]; other site 482957012143 Mg++ binding site [ion binding]; other site 482957012144 motif III; other site 482957012145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957012146 nucleotide binding region [chemical binding]; other site 482957012147 ATP-binding site [chemical binding]; other site 482957012148 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 482957012149 dinuclear metal binding motif [ion binding]; other site 482957012150 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 482957012151 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 482957012152 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 482957012153 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 482957012154 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 482957012155 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 482957012156 glycerol kinase; Provisional; Region: glpK; PRK00047 482957012157 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 482957012158 N- and C-terminal domain interface [polypeptide binding]; other site 482957012159 active site 482957012160 MgATP binding site [chemical binding]; other site 482957012161 catalytic site [active] 482957012162 metal binding site [ion binding]; metal-binding site 482957012163 glycerol binding site [chemical binding]; other site 482957012164 homotetramer interface [polypeptide binding]; other site 482957012165 homodimer interface [polypeptide binding]; other site 482957012166 FBP binding site [chemical binding]; other site 482957012167 protein IIAGlc interface [polypeptide binding]; other site 482957012168 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 482957012169 amphipathic channel; other site 482957012170 Asn-Pro-Ala signature motifs; other site 482957012171 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 482957012172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957012173 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 482957012174 [2Fe-2S] cluster binding site [ion binding]; other site 482957012175 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 482957012176 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 482957012177 putative di-iron ligands [ion binding]; other site 482957012178 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957012179 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957012180 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 482957012181 putative ligand binding site [chemical binding]; other site 482957012182 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 482957012183 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 482957012184 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 482957012185 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 482957012186 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 482957012187 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 482957012188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957012189 motif II; other site 482957012190 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 482957012191 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 482957012192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957012193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957012194 non-specific DNA binding site [nucleotide binding]; other site 482957012195 salt bridge; other site 482957012196 sequence-specific DNA binding site [nucleotide binding]; other site 482957012197 Cupin domain; Region: Cupin_2; pfam07883 482957012198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957012199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957012200 putative substrate translocation pore; other site 482957012201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957012202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957012203 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957012204 putative effector binding pocket; other site 482957012205 dimerization interface [polypeptide binding]; other site 482957012206 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 482957012207 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 482957012208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957012209 FeS/SAM binding site; other site 482957012210 TRAM domain; Region: TRAM; pfam01938 482957012211 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 482957012212 PhoH-like protein; Region: PhoH; pfam02562 482957012213 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 482957012214 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 482957012215 putative active site pocket [active] 482957012216 dimerization interface [polypeptide binding]; other site 482957012217 putative catalytic residue [active] 482957012218 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 482957012219 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 482957012220 Transporter associated domain; Region: CorC_HlyC; smart01091 482957012221 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 482957012222 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 482957012223 putative active site [active] 482957012224 catalytic triad [active] 482957012225 putative dimer interface [polypeptide binding]; other site 482957012226 TPR repeat; Region: TPR_11; pfam13414 482957012227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957012228 binding surface 482957012229 TPR motif; other site 482957012230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957012231 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 482957012232 dimer interface [polypeptide binding]; other site 482957012233 motif 1; other site 482957012234 active site 482957012235 motif 2; other site 482957012236 motif 3; other site 482957012237 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 482957012238 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 482957012239 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 482957012240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957012241 active site 482957012242 motif I; other site 482957012243 motif II; other site 482957012244 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 482957012245 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 482957012246 putative acyl-acceptor binding pocket; other site 482957012247 Protein of unknown function DUF45; Region: DUF45; pfam01863 482957012248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957012249 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 482957012250 dimer interface [polypeptide binding]; other site 482957012251 active site 482957012252 metal binding site [ion binding]; metal-binding site 482957012253 glutathione binding site [chemical binding]; other site 482957012254 EamA-like transporter family; Region: EamA; pfam00892 482957012255 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 482957012256 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 482957012257 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 482957012258 SurA N-terminal domain; Region: SurA_N; pfam09312 482957012259 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 482957012260 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 482957012261 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 482957012262 Organic solvent tolerance protein; Region: OstA_C; pfam04453 482957012263 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 482957012264 Phosphotransferase enzyme family; Region: APH; pfam01636 482957012265 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 482957012266 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 482957012267 Substrate binding site; other site 482957012268 metal-binding site 482957012269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957012270 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 482957012271 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 482957012272 Walker A/P-loop; other site 482957012273 ATP binding site [chemical binding]; other site 482957012274 Q-loop/lid; other site 482957012275 ABC transporter signature motif; other site 482957012276 Walker B; other site 482957012277 D-loop; other site 482957012278 H-loop/switch region; other site 482957012279 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 482957012280 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 482957012281 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 482957012282 enoyl-CoA hydratase; Provisional; Region: PRK06688 482957012283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957012284 substrate binding site [chemical binding]; other site 482957012285 oxyanion hole (OAH) forming residues; other site 482957012286 trimer interface [polypeptide binding]; other site 482957012287 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 482957012288 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957012289 dimer interface [polypeptide binding]; other site 482957012290 active site 482957012291 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 482957012292 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957012293 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957012294 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 482957012295 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957012296 substrate binding site [chemical binding]; other site 482957012297 oxyanion hole (OAH) forming residues; other site 482957012298 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 482957012299 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 482957012300 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 482957012301 FAD binding site [chemical binding]; other site 482957012302 substrate binding site [chemical binding]; other site 482957012303 catalytic residues [active] 482957012304 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 482957012305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957012306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957012307 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 482957012308 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 482957012309 putative active site [active] 482957012310 catalytic site [active] 482957012311 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 482957012312 putative active site [active] 482957012313 catalytic site [active] 482957012314 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 482957012315 nudix motif; other site 482957012316 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 482957012317 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 482957012318 dimer interface [polypeptide binding]; other site 482957012319 anticodon binding site; other site 482957012320 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 482957012321 homodimer interface [polypeptide binding]; other site 482957012322 motif 1; other site 482957012323 active site 482957012324 motif 2; other site 482957012325 GAD domain; Region: GAD; pfam02938 482957012326 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 482957012327 motif 3; other site 482957012328 Uncharacterized conserved protein [Function unknown]; Region: COG2928 482957012329 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 482957012330 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 482957012331 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 482957012332 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 482957012333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 482957012334 SCP-2 sterol transfer family; Region: SCP2; pfam02036 482957012335 Tim44-like domain; Region: Tim44; pfam04280 482957012336 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 482957012337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957012338 S-adenosylmethionine binding site [chemical binding]; other site 482957012339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 482957012340 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 482957012341 nucleotide binding site/active site [active] 482957012342 HIT family signature motif; other site 482957012343 catalytic residue [active] 482957012344 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 482957012345 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957012346 FAD binding domain; Region: FAD_binding_4; pfam01565 482957012347 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957012348 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 482957012349 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 482957012350 Cysteine-rich domain; Region: CCG; pfam02754 482957012351 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 482957012352 threonine dehydratase; Reviewed; Region: PRK09224 482957012353 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 482957012354 tetramer interface [polypeptide binding]; other site 482957012355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957012356 catalytic residue [active] 482957012357 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 482957012358 putative Ile/Val binding site [chemical binding]; other site 482957012359 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 482957012360 putative Ile/Val binding site [chemical binding]; other site 482957012361 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 482957012362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 482957012363 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 482957012364 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 482957012365 dimer interface [polypeptide binding]; other site 482957012366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957012367 ligand binding site [chemical binding]; other site 482957012368 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957012369 homotrimer interaction site [polypeptide binding]; other site 482957012370 putative active site [active] 482957012371 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 482957012372 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 482957012373 active site 482957012374 putative substrate binding pocket [chemical binding]; other site 482957012375 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 482957012376 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957012377 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 482957012378 putative active site [active] 482957012379 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 482957012380 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 482957012381 dimer interface [polypeptide binding]; other site 482957012382 active site 482957012383 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957012384 substrate binding site [chemical binding]; other site 482957012385 catalytic residue [active] 482957012386 intracellular protease, PfpI family; Region: PfpI; TIGR01382 482957012387 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 482957012388 conserved cys residue [active] 482957012389 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957012390 MarR family; Region: MarR; pfam01047 482957012391 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957012392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957012393 putative substrate translocation pore; other site 482957012394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957012395 EcsC protein family; Region: EcsC; pfam12787 482957012396 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957012397 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 482957012398 CHRD domain; Region: CHRD; pfam07452 482957012399 aldolase II superfamily protein; Provisional; Region: PRK07044 482957012400 intersubunit interface [polypeptide binding]; other site 482957012401 active site 482957012402 Zn2+ binding site [ion binding]; other site 482957012403 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 482957012404 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 482957012405 putative active site [active] 482957012406 catalytic site [active] 482957012407 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 482957012408 putative active site [active] 482957012409 catalytic site [active] 482957012410 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957012411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957012412 DNA-binding site [nucleotide binding]; DNA binding site 482957012413 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957012414 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 482957012415 Cysteine-rich domain; Region: CCG; pfam02754 482957012416 Cysteine-rich domain; Region: CCG; pfam02754 482957012417 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 482957012418 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 482957012419 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 482957012420 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 482957012421 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 482957012422 L-lactate permease; Region: Lactate_perm; cl00701 482957012423 glycolate transporter; Provisional; Region: PRK09695 482957012424 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 482957012425 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 482957012426 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 482957012427 Ligand binding site; other site 482957012428 Putative Catalytic site; other site 482957012429 DXD motif; other site 482957012430 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 482957012431 homotrimer interaction site [polypeptide binding]; other site 482957012432 putative active site [active] 482957012433 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957012434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957012435 NAD(P) binding site [chemical binding]; other site 482957012436 active site 482957012437 acyl carrier protein; Provisional; Region: PRK09184 482957012438 Predicted membrane protein [Function unknown]; Region: COG4648 482957012439 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 482957012440 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957012441 acyl-activating enzyme (AAE) consensus motif; other site 482957012442 AMP binding site [chemical binding]; other site 482957012443 active site 482957012444 CoA binding site [chemical binding]; other site 482957012445 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 482957012446 putative acyl-acceptor binding pocket; other site 482957012447 Predicted exporter [General function prediction only]; Region: COG4258 482957012448 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 482957012449 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 482957012450 NodB motif; other site 482957012451 active site 482957012452 catalytic site [active] 482957012453 metal binding site [ion binding]; metal-binding site 482957012454 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 482957012455 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 482957012456 dimer interface [polypeptide binding]; other site 482957012457 active site 482957012458 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 482957012459 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 482957012460 putative active site 1 [active] 482957012461 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 482957012462 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 482957012463 NAD(P) binding site [chemical binding]; other site 482957012464 homotetramer interface [polypeptide binding]; other site 482957012465 homodimer interface [polypeptide binding]; other site 482957012466 active site 482957012467 putative acyltransferase; Provisional; Region: PRK05790 482957012468 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957012469 dimer interface [polypeptide binding]; other site 482957012470 active site 482957012471 Phasin protein; Region: Phasin_2; pfam09361 482957012472 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 482957012473 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957012474 P-loop; other site 482957012475 Magnesium ion binding site [ion binding]; other site 482957012476 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957012477 Magnesium ion binding site [ion binding]; other site 482957012478 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 482957012479 active site 482957012480 DNA binding site [nucleotide binding] 482957012481 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 482957012482 active site 482957012483 SUMO-1 interface [polypeptide binding]; other site 482957012484 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 482957012485 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 482957012486 dimer interface [polypeptide binding]; other site 482957012487 ssDNA binding site [nucleotide binding]; other site 482957012488 tetramer (dimer of dimers) interface [polypeptide binding]; other site 482957012489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957012490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957012491 putative substrate translocation pore; other site 482957012492 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 482957012493 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 482957012494 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 482957012495 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 482957012496 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 482957012497 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 482957012498 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 482957012499 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 482957012500 putative active site [active] 482957012501 putative substrate binding site [chemical binding]; other site 482957012502 putative cosubstrate binding site; other site 482957012503 catalytic site [active] 482957012504 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 482957012505 nudix motif; other site 482957012506 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957012507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957012508 active site 482957012509 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 482957012510 TrkA-N domain; Region: TrkA_N; pfam02254 482957012511 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 482957012512 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 482957012513 putative active site [active] 482957012514 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 482957012515 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 482957012516 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 482957012517 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 482957012518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 482957012519 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 482957012520 OstA-like protein; Region: OstA; pfam03968 482957012521 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 482957012522 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 482957012523 Walker A/P-loop; other site 482957012524 ATP binding site [chemical binding]; other site 482957012525 Q-loop/lid; other site 482957012526 ABC transporter signature motif; other site 482957012527 Walker B; other site 482957012528 D-loop; other site 482957012529 H-loop/switch region; other site 482957012530 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 482957012531 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 482957012532 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 482957012533 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 482957012534 30S subunit binding site; other site 482957012535 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 482957012536 active site 482957012537 phosphorylation site [posttranslational modification] 482957012538 HPr kinase/phosphorylase; Provisional; Region: PRK05428 482957012539 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 482957012540 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 482957012541 Hpr binding site; other site 482957012542 active site 482957012543 homohexamer subunit interaction site [polypeptide binding]; other site 482957012544 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 482957012545 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 482957012546 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 482957012547 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 482957012548 minor groove reading motif; other site 482957012549 helix-hairpin-helix signature motif; other site 482957012550 substrate binding pocket [chemical binding]; other site 482957012551 active site 482957012552 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 482957012553 DNA binding and oxoG recognition site [nucleotide binding] 482957012554 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 482957012555 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 482957012556 DNA binding site [nucleotide binding] 482957012557 catalytic residue [active] 482957012558 H2TH interface [polypeptide binding]; other site 482957012559 putative catalytic residues [active] 482957012560 turnover-facilitating residue; other site 482957012561 intercalation triad [nucleotide binding]; other site 482957012562 8OG recognition residue [nucleotide binding]; other site 482957012563 putative reading head residues; other site 482957012564 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 482957012565 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 482957012566 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 482957012567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957012568 TPR motif; other site 482957012569 binding surface 482957012570 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 482957012571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957012572 binding surface 482957012573 TPR motif; other site 482957012574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957012575 binding surface 482957012576 TPR motif; other site 482957012577 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 482957012578 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 482957012579 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 482957012580 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 482957012581 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 482957012582 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 482957012583 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 482957012584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957012585 active site 482957012586 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 482957012587 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 482957012588 5S rRNA interface [nucleotide binding]; other site 482957012589 CTC domain interface [polypeptide binding]; other site 482957012590 L16 interface [polypeptide binding]; other site 482957012591 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 482957012592 putative active site [active] 482957012593 catalytic residue [active] 482957012594 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 482957012595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957012596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957012597 homodimer interface [polypeptide binding]; other site 482957012598 catalytic residue [active] 482957012599 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 482957012600 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 482957012601 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 482957012602 active site 482957012603 (T/H)XGH motif; other site 482957012604 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 482957012605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957012606 S-adenosylmethionine binding site [chemical binding]; other site 482957012607 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 482957012608 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 482957012609 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 482957012610 P loop; other site 482957012611 GTP binding site [chemical binding]; other site 482957012612 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 482957012613 maleylacetoacetate isomerase; Region: maiA; TIGR01262 482957012614 C-terminal domain interface [polypeptide binding]; other site 482957012615 GSH binding site (G-site) [chemical binding]; other site 482957012616 putative dimer interface [polypeptide binding]; other site 482957012617 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 482957012618 dimer interface [polypeptide binding]; other site 482957012619 N-terminal domain interface [polypeptide binding]; other site 482957012620 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 482957012621 glycosyl transferase family protein; Provisional; Region: PRK08136 482957012622 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 482957012623 2-isopropylmalate synthase; Validated; Region: PRK03739 482957012624 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 482957012625 active site 482957012626 catalytic residues [active] 482957012627 metal binding site [ion binding]; metal-binding site 482957012628 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 482957012629 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 482957012630 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 482957012631 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 482957012632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957012633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957012634 DNA binding residues [nucleotide binding] 482957012635 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 482957012636 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 482957012637 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 482957012638 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 482957012639 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 482957012640 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 482957012641 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 482957012642 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 482957012643 active site 482957012644 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 482957012645 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 482957012646 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 482957012647 active site turn [active] 482957012648 phosphorylation site [posttranslational modification] 482957012649 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 482957012650 HPr interaction site; other site 482957012651 glycerol kinase (GK) interaction site [polypeptide binding]; other site 482957012652 active site 482957012653 phosphorylation site [posttranslational modification] 482957012654 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 482957012655 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 482957012656 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 482957012657 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 482957012658 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 482957012659 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 482957012660 dimer interface [polypeptide binding]; other site 482957012661 active site 482957012662 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 482957012663 dimer interface [polypeptide binding]; other site 482957012664 active site 482957012665 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 482957012666 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 482957012667 active site 482957012668 dimer interface [polypeptide binding]; other site 482957012669 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 482957012670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957012671 DNA-binding site [nucleotide binding]; DNA binding site 482957012672 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 482957012673 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 482957012674 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 482957012675 putative active site [active] 482957012676 putative PHP Thumb interface [polypeptide binding]; other site 482957012677 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 482957012678 generic binding surface II; other site 482957012679 generic binding surface I; other site 482957012680 DNA Polymerase Y-family; Region: PolY_like; cd03468 482957012681 active site 482957012682 DNA binding site [nucleotide binding] 482957012683 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 482957012684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957012685 Walker A/P-loop; other site 482957012686 ATP binding site [chemical binding]; other site 482957012687 Q-loop/lid; other site 482957012688 ABC transporter signature motif; other site 482957012689 Walker B; other site 482957012690 D-loop; other site 482957012691 H-loop/switch region; other site 482957012692 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957012693 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 482957012694 TM-ABC transporter signature motif; other site 482957012695 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 482957012696 zinc binding site [ion binding]; other site 482957012697 putative ligand binding site [chemical binding]; other site 482957012698 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 482957012699 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 482957012700 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 482957012701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 482957012702 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957012703 dimer interface [polypeptide binding]; other site 482957012704 putative CheW interface [polypeptide binding]; other site 482957012705 YCII-related domain; Region: YCII; cl00999 482957012706 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 482957012707 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 482957012708 Cu(I) binding site [ion binding]; other site 482957012709 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 482957012710 UbiA prenyltransferase family; Region: UbiA; pfam01040 482957012711 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 482957012712 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 482957012713 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 482957012714 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 482957012715 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 482957012716 Subunit III/VIIa interface [polypeptide binding]; other site 482957012717 Phospholipid binding site [chemical binding]; other site 482957012718 Subunit I/III interface [polypeptide binding]; other site 482957012719 Subunit III/VIb interface [polypeptide binding]; other site 482957012720 Subunit III/VIa interface; other site 482957012721 Subunit III/Vb interface [polypeptide binding]; other site 482957012722 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 482957012723 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 482957012724 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 482957012725 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 482957012726 Subunit I/III interface [polypeptide binding]; other site 482957012727 D-pathway; other site 482957012728 Subunit I/VIIc interface [polypeptide binding]; other site 482957012729 Subunit I/IV interface [polypeptide binding]; other site 482957012730 Subunit I/II interface [polypeptide binding]; other site 482957012731 Low-spin heme (heme a) binding site [chemical binding]; other site 482957012732 Subunit I/VIIa interface [polypeptide binding]; other site 482957012733 Subunit I/VIa interface [polypeptide binding]; other site 482957012734 Dimer interface; other site 482957012735 Putative water exit pathway; other site 482957012736 Binuclear center (heme a3/CuB) [ion binding]; other site 482957012737 K-pathway; other site 482957012738 Subunit I/Vb interface [polypeptide binding]; other site 482957012739 Putative proton exit pathway; other site 482957012740 Subunit I/VIb interface; other site 482957012741 Subunit I/VIc interface [polypeptide binding]; other site 482957012742 Electron transfer pathway; other site 482957012743 Subunit I/VIIIb interface [polypeptide binding]; other site 482957012744 Subunit I/VIIb interface [polypeptide binding]; other site 482957012745 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 482957012746 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 482957012747 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 482957012748 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957012749 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 482957012750 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957012751 ligand binding site [chemical binding]; other site 482957012752 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 482957012753 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 482957012754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957012755 S-adenosylmethionine binding site [chemical binding]; other site 482957012756 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 482957012757 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 482957012758 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 482957012759 putative ADP-ribose binding site [chemical binding]; other site 482957012760 putative active site [active] 482957012761 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 482957012762 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 482957012763 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 482957012764 preprotein translocase subunit SecB; Validated; Region: PRK05751 482957012765 SecA binding site; other site 482957012766 Preprotein binding site; other site 482957012767 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 482957012768 GSH binding site [chemical binding]; other site 482957012769 catalytic residues [active] 482957012770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 482957012771 active site residue [active] 482957012772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 482957012773 catalytic core [active] 482957012774 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 482957012775 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 482957012776 C-terminal peptidase (prc); Region: prc; TIGR00225 482957012777 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 482957012778 protein binding site [polypeptide binding]; other site 482957012779 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 482957012780 Catalytic dyad [active] 482957012781 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 482957012782 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 482957012783 ATP binding site [chemical binding]; other site 482957012784 substrate interface [chemical binding]; other site 482957012785 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 482957012786 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 482957012787 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 482957012788 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 482957012789 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 482957012790 dimerization domain swap beta strand [polypeptide binding]; other site 482957012791 regulatory protein interface [polypeptide binding]; other site 482957012792 active site 482957012793 regulatory phosphorylation site [posttranslational modification]; other site 482957012794 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 482957012795 active pocket/dimerization site; other site 482957012796 active site 482957012797 phosphorylation site [posttranslational modification] 482957012798 glutathione synthetase; Provisional; Region: PRK05246 482957012799 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 482957012800 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 482957012801 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 482957012802 Glutamate-cysteine ligase; Region: GshA; pfam08886 482957012803 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 482957012804 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 482957012805 Nitrogen regulatory protein P-II; Region: P-II; smart00938 482957012806 Membrane fusogenic activity; Region: BMFP; pfam04380 482957012807 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 482957012808 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 482957012809 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 482957012810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957012811 non-specific DNA binding site [nucleotide binding]; other site 482957012812 salt bridge; other site 482957012813 sequence-specific DNA binding site [nucleotide binding]; other site 482957012814 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957012815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957012816 non-specific DNA binding site [nucleotide binding]; other site 482957012817 salt bridge; other site 482957012818 sequence-specific DNA binding site [nucleotide binding]; other site 482957012819 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 482957012820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957012821 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 482957012822 active site 482957012823 catalytic residues [active] 482957012824 DNA binding site [nucleotide binding] 482957012825 Int/Topo IB signature motif; other site 482957012826 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 482957012827 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957012828 active site 482957012829 DNA binding site [nucleotide binding] 482957012830 Int/Topo IB signature motif; other site 482957012831 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 482957012832 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 482957012833 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 482957012834 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 482957012835 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957012836 catalytic residues [active] 482957012837 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957012838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957012839 active site 482957012840 phosphorylation site [posttranslational modification] 482957012841 intermolecular recognition site; other site 482957012842 dimerization interface [polypeptide binding]; other site 482957012843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957012844 Walker A motif; other site 482957012845 ATP binding site [chemical binding]; other site 482957012846 Walker B motif; other site 482957012847 arginine finger; other site 482957012848 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957012849 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 482957012850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957012851 dimer interface [polypeptide binding]; other site 482957012852 phosphorylation site [posttranslational modification] 482957012853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957012854 ATP binding site [chemical binding]; other site 482957012855 Mg2+ binding site [ion binding]; other site 482957012856 G-X-G motif; other site 482957012857 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 482957012858 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 482957012859 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 482957012860 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 482957012861 Na binding site [ion binding]; other site 482957012862 Protein of unknown function, DUF485; Region: DUF485; pfam04341 482957012863 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957012864 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957012865 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 482957012866 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957012867 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957012868 active site 482957012869 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 482957012870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957012871 active site 482957012872 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957012873 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 482957012874 substrate binding site [chemical binding]; other site 482957012875 oxyanion hole (OAH) forming residues; other site 482957012876 trimer interface [polypeptide binding]; other site 482957012877 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957012878 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957012879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957012880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957012881 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957012882 putative effector binding pocket; other site 482957012883 dimerization interface [polypeptide binding]; other site 482957012884 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 482957012885 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 482957012886 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957012887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957012888 dimer interface [polypeptide binding]; other site 482957012889 conserved gate region; other site 482957012890 putative PBP binding loops; other site 482957012891 ABC-ATPase subunit interface; other site 482957012892 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 482957012893 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957012894 Walker A/P-loop; other site 482957012895 ATP binding site [chemical binding]; other site 482957012896 Q-loop/lid; other site 482957012897 ABC transporter signature motif; other site 482957012898 Walker B; other site 482957012899 D-loop; other site 482957012900 H-loop/switch region; other site 482957012901 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 482957012902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957012903 substrate binding pocket [chemical binding]; other site 482957012904 membrane-bound complex binding site; other site 482957012905 hinge residues; other site 482957012906 HipA N-terminal domain; Region: Couple_hipA; cl11853 482957012907 HipA-like N-terminal domain; Region: HipA_N; pfam07805 482957012908 HipA-like C-terminal domain; Region: HipA_C; pfam07804 482957012909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957012910 sequence-specific DNA binding site [nucleotide binding]; other site 482957012911 salt bridge; other site 482957012912 lipoyl synthase; Provisional; Region: PRK05481 482957012913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957012914 FeS/SAM binding site; other site 482957012915 lipoate-protein ligase B; Provisional; Region: PRK14343 482957012916 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 482957012917 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957012918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957012919 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957012920 dimerization interface [polypeptide binding]; other site 482957012921 substrate binding pocket [chemical binding]; other site 482957012922 hypothetical protein; Provisional; Region: PRK02047 482957012923 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 482957012924 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 482957012925 homodimer interface [polypeptide binding]; other site 482957012926 substrate-cofactor binding pocket; other site 482957012927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957012928 catalytic residue [active] 482957012929 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 482957012930 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 482957012931 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 482957012932 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 482957012933 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 482957012934 dimer interface [polypeptide binding]; other site 482957012935 [2Fe-2S] cluster binding site [ion binding]; other site 482957012936 Predicted integral membrane protein [Function unknown]; Region: COG5652 482957012937 Protein of unknown function (DUF330); Region: DUF330; pfam03886 482957012938 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 482957012939 mce related protein; Region: MCE; pfam02470 482957012940 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 482957012941 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 482957012942 Walker A/P-loop; other site 482957012943 ATP binding site [chemical binding]; other site 482957012944 Q-loop/lid; other site 482957012945 ABC transporter signature motif; other site 482957012946 Walker B; other site 482957012947 D-loop; other site 482957012948 H-loop/switch region; other site 482957012949 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 482957012950 Permease; Region: Permease; pfam02405 482957012951 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 482957012952 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 482957012953 active site 482957012954 metal binding site [ion binding]; metal-binding site 482957012955 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 482957012956 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957012957 biotin--protein ligase; Provisional; Region: PRK06955 482957012958 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 482957012959 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 482957012960 pantothenate kinase; Reviewed; Region: PRK13328 482957012961 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 482957012962 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 482957012963 active site 482957012964 HIGH motif; other site 482957012965 nucleotide binding site [chemical binding]; other site 482957012966 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 482957012967 dinuclear metal binding motif [ion binding]; other site 482957012968 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 482957012969 active site 482957012970 nucleophile elbow; other site 482957012971 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 482957012972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957012973 substrate binding site [chemical binding]; other site 482957012974 oxyanion hole (OAH) forming residues; other site 482957012975 trimer interface [polypeptide binding]; other site 482957012976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 482957012977 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 482957012978 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957012979 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957012980 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957012981 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 482957012982 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 482957012983 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 482957012984 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 482957012985 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 482957012986 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 482957012987 substrate binding pocket [chemical binding]; other site 482957012988 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 482957012989 B12 binding site [chemical binding]; other site 482957012990 cobalt ligand [ion binding]; other site 482957012991 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 482957012992 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 482957012993 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 482957012994 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 482957012995 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 482957012996 active site 482957012997 HIGH motif; other site 482957012998 KMSK motif region; other site 482957012999 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 482957013000 tRNA binding surface [nucleotide binding]; other site 482957013001 anticodon binding site; other site 482957013002 Sporulation related domain; Region: SPOR; pfam05036 482957013003 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 482957013004 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 482957013005 catalytic residues [active] 482957013006 hinge region; other site 482957013007 alpha helical domain; other site 482957013008 short chain dehydrogenase; Provisional; Region: PRK07024 482957013009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957013010 NAD(P) binding site [chemical binding]; other site 482957013011 active site 482957013012 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 482957013013 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 482957013014 peptide binding site [polypeptide binding]; other site 482957013015 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 482957013016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957013017 Walker A/P-loop; other site 482957013018 ATP binding site [chemical binding]; other site 482957013019 Q-loop/lid; other site 482957013020 ABC transporter signature motif; other site 482957013021 Walker B; other site 482957013022 D-loop; other site 482957013023 H-loop/switch region; other site 482957013024 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 482957013025 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 482957013026 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 482957013027 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 482957013028 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 482957013029 active site clefts [active] 482957013030 zinc binding site [ion binding]; other site 482957013031 dimer interface [polypeptide binding]; other site 482957013032 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 482957013033 C factor cell-cell signaling protein; Provisional; Region: PRK09009 482957013034 NADP binding site [chemical binding]; other site 482957013035 homodimer interface [polypeptide binding]; other site 482957013036 active site 482957013037 hypothetical protein; Provisional; Region: PRK01842 482957013038 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 482957013039 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957013040 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 482957013041 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957013042 inhibitor-cofactor binding pocket; inhibition site 482957013043 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957013044 catalytic residue [active] 482957013045 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 482957013046 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 482957013047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957013048 catalytic residue [active] 482957013049 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 482957013050 AAA domain; Region: AAA_26; pfam13500 482957013051 biotin synthase; Region: bioB; TIGR00433 482957013052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957013053 FeS/SAM binding site; other site 482957013054 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 482957013055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957013056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013057 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 482957013058 putative substrate binding pocket [chemical binding]; other site 482957013059 dimerization interface [polypeptide binding]; other site 482957013060 hypothetical protein; Provisional; Region: PRK12569 482957013061 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 482957013062 carboxyltransferase (CT) interaction site; other site 482957013063 biotinylation site [posttranslational modification]; other site 482957013064 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 482957013065 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 482957013066 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 482957013067 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 482957013068 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 482957013069 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 482957013070 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 482957013071 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 482957013072 CutC family; Region: CutC; cl01218 482957013073 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957013074 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 482957013075 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 482957013076 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 482957013077 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 482957013078 dimer interface [polypeptide binding]; other site 482957013079 PYR/PP interface [polypeptide binding]; other site 482957013080 TPP binding site [chemical binding]; other site 482957013081 substrate binding site [chemical binding]; other site 482957013082 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 482957013083 TPP-binding site; other site 482957013084 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 482957013085 maltose O-acetyltransferase; Provisional; Region: PRK10092 482957013086 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 482957013087 active site 482957013088 substrate binding site [chemical binding]; other site 482957013089 trimer interface [polypeptide binding]; other site 482957013090 CoA binding site [chemical binding]; other site 482957013091 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957013092 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 482957013093 putative C-terminal domain interface [polypeptide binding]; other site 482957013094 putative GSH binding site (G-site) [chemical binding]; other site 482957013095 putative dimer interface [polypeptide binding]; other site 482957013096 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 482957013097 dimer interface [polypeptide binding]; other site 482957013098 N-terminal domain interface [polypeptide binding]; other site 482957013099 putative substrate binding pocket (H-site) [chemical binding]; other site 482957013100 Inward rectifier potassium channel; Region: IRK; pfam01007 482957013101 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 482957013102 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 482957013103 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957013104 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 482957013105 dimer interface [polypeptide binding]; other site 482957013106 active site 482957013107 catalytic residue [active] 482957013108 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 482957013109 putative active site [active] 482957013110 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 482957013111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013112 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957013113 dimerization interface [polypeptide binding]; other site 482957013114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957013115 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957013116 putative substrate translocation pore; other site 482957013117 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 482957013118 C-terminal domain interface [polypeptide binding]; other site 482957013119 GSH binding site (G-site) [chemical binding]; other site 482957013120 dimer interface [polypeptide binding]; other site 482957013121 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 482957013122 dimer interface [polypeptide binding]; other site 482957013123 N-terminal domain interface [polypeptide binding]; other site 482957013124 substrate binding pocket (H-site) [chemical binding]; other site 482957013125 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957013126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013127 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957013128 dimerization interface [polypeptide binding]; other site 482957013129 substrate binding pocket [chemical binding]; other site 482957013130 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957013131 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957013132 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957013133 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957013134 Serine hydrolase; Region: Ser_hydrolase; pfam06821 482957013135 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 482957013136 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 482957013137 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 482957013138 putative ligand binding site [chemical binding]; other site 482957013139 NAD binding site [chemical binding]; other site 482957013140 dimerization interface [polypeptide binding]; other site 482957013141 catalytic site [active] 482957013142 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 482957013143 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 482957013144 active site 482957013145 catalytic residues [active] 482957013146 metal binding site [ion binding]; metal-binding site 482957013147 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 482957013148 putative deacylase active site [active] 482957013149 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 482957013150 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 482957013151 EamA-like transporter family; Region: EamA; cl17759 482957013152 EamA-like transporter family; Region: EamA; pfam00892 482957013153 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957013154 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 482957013155 AsnC family; Region: AsnC_trans_reg; pfam01037 482957013156 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957013157 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 482957013158 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957013159 FMN binding site [chemical binding]; other site 482957013160 substrate binding site [chemical binding]; other site 482957013161 putative catalytic residue [active] 482957013162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957013163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013164 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957013165 putative effector binding pocket; other site 482957013166 dimerization interface [polypeptide binding]; other site 482957013167 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957013168 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957013169 trimer interface [polypeptide binding]; other site 482957013170 eyelet of channel; other site 482957013171 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 482957013172 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 482957013173 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957013174 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 482957013175 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957013176 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957013177 metal binding site [ion binding]; metal-binding site 482957013178 active site 482957013179 I-site; other site 482957013180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957013181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957013182 DNA binding site [nucleotide binding] 482957013183 domain linker motif; other site 482957013184 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 482957013185 ligand binding site [chemical binding]; other site 482957013186 dimerization interface [polypeptide binding]; other site 482957013187 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 482957013188 dimerization interface [polypeptide binding]; other site 482957013189 putative active cleft [active] 482957013190 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 482957013191 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 482957013192 putative substrate binding site [chemical binding]; other site 482957013193 putative ATP binding site [chemical binding]; other site 482957013194 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 482957013195 Uncharacterized conserved protein [Function unknown]; Region: COG1565 482957013196 short chain dehydrogenase; Provisional; Region: PRK09134 482957013197 Dihydroneopterin aldolase; Region: FolB; smart00905 482957013198 active site 482957013199 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 482957013200 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 482957013201 Ligand Binding Site [chemical binding]; other site 482957013202 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 482957013203 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 482957013204 Substrate binding site; other site 482957013205 Mg++ binding site; other site 482957013206 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 482957013207 active site 482957013208 substrate binding site [chemical binding]; other site 482957013209 CoA binding site [chemical binding]; other site 482957013210 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 482957013211 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 482957013212 glutaminase active site [active] 482957013213 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 482957013214 dimer interface [polypeptide binding]; other site 482957013215 active site 482957013216 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 482957013217 dimer interface [polypeptide binding]; other site 482957013218 active site 482957013219 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 482957013220 Predicted transcriptional regulator [Transcription]; Region: COG2944 482957013221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957013222 non-specific DNA binding site [nucleotide binding]; other site 482957013223 salt bridge; other site 482957013224 sequence-specific DNA binding site [nucleotide binding]; other site 482957013225 Iron permease FTR1 family; Region: FTR1; cl00475 482957013226 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 482957013227 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 482957013228 metal-binding site [ion binding] 482957013229 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 482957013230 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 482957013231 NAD(P) binding site [chemical binding]; other site 482957013232 catalytic residues [active] 482957013233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957013234 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 482957013235 non-specific DNA binding site [nucleotide binding]; other site 482957013236 salt bridge; other site 482957013237 sequence-specific DNA binding site [nucleotide binding]; other site 482957013238 Cupin domain; Region: Cupin_2; pfam07883 482957013239 Peptidase C26; Region: Peptidase_C26; pfam07722 482957013240 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 482957013241 catalytic triad [active] 482957013242 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 482957013243 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 482957013244 putative aminotransferase; Validated; Region: PRK07480 482957013245 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957013246 inhibitor-cofactor binding pocket; inhibition site 482957013247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957013248 catalytic residue [active] 482957013249 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 482957013250 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957013251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957013252 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 482957013253 Walker A/P-loop; other site 482957013254 ATP binding site [chemical binding]; other site 482957013255 Q-loop/lid; other site 482957013256 ABC transporter signature motif; other site 482957013257 Walker B; other site 482957013258 D-loop; other site 482957013259 H-loop/switch region; other site 482957013260 TOBE domain; Region: TOBE_2; pfam08402 482957013261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957013262 dimer interface [polypeptide binding]; other site 482957013263 conserved gate region; other site 482957013264 putative PBP binding loops; other site 482957013265 ABC-ATPase subunit interface; other site 482957013266 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957013267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957013268 dimer interface [polypeptide binding]; other site 482957013269 conserved gate region; other site 482957013270 putative PBP binding loops; other site 482957013271 ABC-ATPase subunit interface; other site 482957013272 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 482957013273 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 482957013274 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957013275 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957013276 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957013277 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957013278 glutathione reductase; Validated; Region: PRK06116 482957013279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957013280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957013281 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 482957013282 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957013283 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957013284 trimer interface [polypeptide binding]; other site 482957013285 eyelet of channel; other site 482957013286 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 482957013287 Chromate transporter; Region: Chromate_transp; pfam02417 482957013288 Chromate transporter; Region: Chromate_transp; pfam02417 482957013289 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957013290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013291 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957013292 dimerization interface [polypeptide binding]; other site 482957013293 substrate binding pocket [chemical binding]; other site 482957013294 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 482957013295 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 482957013296 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 482957013297 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 482957013298 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 482957013299 Flagellar regulator YcgR; Region: YcgR; pfam07317 482957013300 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 482957013301 PilZ domain; Region: PilZ; pfam07238 482957013302 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 482957013303 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 482957013304 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 482957013305 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 482957013306 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 482957013307 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 482957013308 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 482957013309 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 482957013310 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 482957013311 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 482957013312 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 482957013313 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 482957013314 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 482957013315 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 482957013316 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 482957013317 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 482957013318 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 482957013319 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 482957013320 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 482957013321 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 482957013322 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 482957013323 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 482957013324 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 482957013325 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 482957013326 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 482957013327 SAF-like; Region: SAF_2; pfam13144 482957013328 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 482957013329 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 482957013330 FlgN protein; Region: FlgN; pfam05130 482957013331 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 482957013332 active site 482957013333 catalytic triad [active] 482957013334 oxyanion hole [active] 482957013335 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 482957013336 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 482957013337 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 482957013338 active site 482957013339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957013340 sequence-specific DNA binding site [nucleotide binding]; other site 482957013341 salt bridge; other site 482957013342 Cupin domain; Region: Cupin_2; pfam07883 482957013343 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 482957013344 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 482957013345 active site 482957013346 NTP binding site [chemical binding]; other site 482957013347 metal binding triad [ion binding]; metal-binding site 482957013348 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 482957013349 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 482957013350 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957013351 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 482957013352 putative C-terminal domain interface [polypeptide binding]; other site 482957013353 putative GSH binding site (G-site) [chemical binding]; other site 482957013354 putative dimer interface [polypeptide binding]; other site 482957013355 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 482957013356 putative N-terminal domain interface [polypeptide binding]; other site 482957013357 putative dimer interface [polypeptide binding]; other site 482957013358 putative substrate binding pocket (H-site) [chemical binding]; other site 482957013359 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 482957013360 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 482957013361 putative NAD(P) binding site [chemical binding]; other site 482957013362 active site 482957013363 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957013364 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957013365 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957013366 catalytic residue [active] 482957013367 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 482957013368 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 482957013369 MarR family; Region: MarR_2; cl17246 482957013370 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957013371 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 482957013372 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 482957013373 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 482957013374 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 482957013375 putative active site [active] 482957013376 TraB family; Region: TraB; pfam01963 482957013377 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 482957013378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957013379 Walker A/P-loop; other site 482957013380 ATP binding site [chemical binding]; other site 482957013381 Q-loop/lid; other site 482957013382 ABC transporter signature motif; other site 482957013383 Walker B; other site 482957013384 D-loop; other site 482957013385 H-loop/switch region; other site 482957013386 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 482957013387 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 482957013388 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957013389 Walker A/P-loop; other site 482957013390 ATP binding site [chemical binding]; other site 482957013391 Q-loop/lid; other site 482957013392 ABC transporter signature motif; other site 482957013393 Walker B; other site 482957013394 D-loop; other site 482957013395 H-loop/switch region; other site 482957013396 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957013397 dipeptide transporter; Provisional; Region: PRK10913 482957013398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957013399 dimer interface [polypeptide binding]; other site 482957013400 conserved gate region; other site 482957013401 putative PBP binding loops; other site 482957013402 ABC-ATPase subunit interface; other site 482957013403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 482957013404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957013405 dimer interface [polypeptide binding]; other site 482957013406 conserved gate region; other site 482957013407 putative PBP binding loops; other site 482957013408 ABC-ATPase subunit interface; other site 482957013409 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 482957013410 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 482957013411 peptide binding site [polypeptide binding]; other site 482957013412 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957013413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957013414 putative substrate translocation pore; other site 482957013415 High potential iron-sulfur protein; Region: HIPIP; pfam01355 482957013416 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957013417 Predicted dehydrogenase [General function prediction only]; Region: COG0579 482957013418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957013419 ATP binding site [chemical binding]; other site 482957013420 Walker B motif; other site 482957013421 arginine finger; other site 482957013422 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 482957013423 putative FMN binding site [chemical binding]; other site 482957013424 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 482957013425 putative catalytic site [active] 482957013426 putative phosphate binding site [ion binding]; other site 482957013427 putative metal binding site [ion binding]; other site 482957013428 LysE type translocator; Region: LysE; cl00565 482957013429 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957013430 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 482957013431 FAD binding pocket [chemical binding]; other site 482957013432 FAD binding motif [chemical binding]; other site 482957013433 phosphate binding motif [ion binding]; other site 482957013434 beta-alpha-beta structure motif; other site 482957013435 NAD binding pocket [chemical binding]; other site 482957013436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 482957013437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957013438 ATP binding site [chemical binding]; other site 482957013439 Mg2+ binding site [ion binding]; other site 482957013440 G-X-G motif; other site 482957013441 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957013442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957013443 active site 482957013444 phosphorylation site [posttranslational modification] 482957013445 intermolecular recognition site; other site 482957013446 dimerization interface [polypeptide binding]; other site 482957013447 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957013448 DNA binding residues [nucleotide binding] 482957013449 dimerization interface [polypeptide binding]; other site 482957013450 amino acid transporter; Region: 2A0306; TIGR00909 482957013451 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 482957013452 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 482957013453 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 482957013454 XdhC Rossmann domain; Region: XdhC_C; pfam13478 482957013455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 482957013456 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 482957013457 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 482957013458 flagellar protein FliS; Validated; Region: fliS; PRK05685 482957013459 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 482957013460 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 482957013461 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 482957013462 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 482957013463 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 482957013464 FliG C-terminal domain; Region: FliG_C; pfam01706 482957013465 flagellar assembly protein H; Validated; Region: fliH; PRK05687 482957013466 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 482957013467 Flagellar assembly protein FliH; Region: FliH; pfam02108 482957013468 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 482957013469 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 482957013470 Walker A motif/ATP binding site; other site 482957013471 Walker B motif; other site 482957013472 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 482957013473 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 482957013474 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 482957013475 choline dehydrogenase; Validated; Region: PRK02106 482957013476 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957013477 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 482957013478 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 482957013479 NAD(P) binding site [chemical binding]; other site 482957013480 catalytic residues [active] 482957013481 serine/threonine protein kinase; Provisional; Region: PRK11768 482957013482 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 482957013483 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957013484 EamA-like transporter family; Region: EamA; pfam00892 482957013485 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957013486 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957013487 active site 482957013488 catalytic tetrad [active] 482957013489 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 482957013490 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 482957013491 S-adenosylmethionine synthetase; Validated; Region: PRK05250 482957013492 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 482957013493 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 482957013494 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 482957013495 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 482957013496 putative acyl-acceptor binding pocket; other site 482957013497 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 482957013498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957013499 sequence-specific DNA binding site [nucleotide binding]; other site 482957013500 salt bridge; other site 482957013501 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 482957013502 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 482957013503 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 482957013504 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 482957013505 Protein of unknown function, DUF484; Region: DUF484; cl17449 482957013506 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 482957013507 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957013508 active site 482957013509 DNA binding site [nucleotide binding] 482957013510 Int/Topo IB signature motif; other site 482957013511 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 482957013512 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 482957013513 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 482957013514 putative RNA binding site [nucleotide binding]; other site 482957013515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957013516 S-adenosylmethionine binding site [chemical binding]; other site 482957013517 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 482957013518 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 482957013519 P-loop, Walker A motif; other site 482957013520 Base recognition motif; other site 482957013521 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 482957013522 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 482957013523 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 482957013524 active site 482957013525 HslU subunit interaction site [polypeptide binding]; other site 482957013526 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 482957013527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957013528 Walker A motif; other site 482957013529 ATP binding site [chemical binding]; other site 482957013530 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 482957013531 Walker B motif; other site 482957013532 arginine finger; other site 482957013533 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 482957013534 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 482957013535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957013536 active site 482957013537 phosphorylation site [posttranslational modification] 482957013538 intermolecular recognition site; other site 482957013539 dimerization interface [polypeptide binding]; other site 482957013540 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957013541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957013542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957013543 dimer interface [polypeptide binding]; other site 482957013544 phosphorylation site [posttranslational modification] 482957013545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957013546 ATP binding site [chemical binding]; other site 482957013547 Mg2+ binding site [ion binding]; other site 482957013548 G-X-G motif; other site 482957013549 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 482957013550 feedback inhibition sensing region; other site 482957013551 homohexameric interface [polypeptide binding]; other site 482957013552 nucleotide binding site [chemical binding]; other site 482957013553 N-acetyl-L-glutamate binding site [chemical binding]; other site 482957013554 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 482957013555 division inhibitor protein; Provisional; Region: slmA; PRK09480 482957013556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957013557 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 482957013558 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 482957013559 Methyltransferase domain; Region: Methyltransf_31; pfam13847 482957013560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957013561 S-adenosylmethionine binding site [chemical binding]; other site 482957013562 muropeptide transporter; Reviewed; Region: ampG; PRK11902 482957013563 AmpG-like permease; Region: 2A0125; TIGR00901 482957013564 Peptidase family M48; Region: Peptidase_M48; cl12018 482957013565 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 482957013566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957013567 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 482957013568 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 482957013569 putative NAD(P) binding site [chemical binding]; other site 482957013570 putative substrate binding site [chemical binding]; other site 482957013571 catalytic Zn binding site [ion binding]; other site 482957013572 structural Zn binding site [ion binding]; other site 482957013573 dimer interface [polypeptide binding]; other site 482957013574 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 482957013575 putative active site [active] 482957013576 putative catalytic site [active] 482957013577 putative DNA binding site [nucleotide binding]; other site 482957013578 putative phosphate binding site [ion binding]; other site 482957013579 metal binding site A [ion binding]; metal-binding site 482957013580 putative AP binding site [nucleotide binding]; other site 482957013581 putative metal binding site B [ion binding]; other site 482957013582 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 482957013583 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 482957013584 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 482957013585 GatB domain; Region: GatB_Yqey; smart00845 482957013586 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 482957013587 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 482957013588 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 482957013589 rod shape-determining protein MreB; Provisional; Region: PRK13927 482957013590 MreB and similar proteins; Region: MreB_like; cd10225 482957013591 nucleotide binding site [chemical binding]; other site 482957013592 Mg binding site [ion binding]; other site 482957013593 putative protofilament interaction site [polypeptide binding]; other site 482957013594 RodZ interaction site [polypeptide binding]; other site 482957013595 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 482957013596 rod shape-determining protein MreC; Region: MreC; pfam04085 482957013597 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 482957013598 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 482957013599 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 482957013600 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 482957013601 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 482957013602 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957013603 Sel1-like repeats; Region: SEL1; smart00671 482957013604 Sel1-like repeats; Region: SEL1; smart00671 482957013605 Sel1-like repeats; Region: SEL1; smart00671 482957013606 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 482957013607 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 482957013608 active site 482957013609 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 482957013610 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 482957013611 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 482957013612 Ligand Binding Site [chemical binding]; other site 482957013613 Response regulator receiver domain; Region: Response_reg; pfam00072 482957013614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957013615 active site 482957013616 phosphorylation site [posttranslational modification] 482957013617 intermolecular recognition site; other site 482957013618 dimerization interface [polypeptide binding]; other site 482957013619 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 482957013620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957013621 dimerization interface [polypeptide binding]; other site 482957013622 PAS domain; Region: PAS; smart00091 482957013623 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 482957013624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957013625 dimer interface [polypeptide binding]; other site 482957013626 phosphorylation site [posttranslational modification] 482957013627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957013628 ATP binding site [chemical binding]; other site 482957013629 Mg2+ binding site [ion binding]; other site 482957013630 G-X-G motif; other site 482957013631 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 482957013632 16S rRNA methyltransferase B; Provisional; Region: PRK10901 482957013633 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 482957013634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957013635 S-adenosylmethionine binding site [chemical binding]; other site 482957013636 M48 family peptidase; Provisional; Region: PRK03001 482957013637 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957013638 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 482957013639 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 482957013640 putative active site [active] 482957013641 substrate binding site [chemical binding]; other site 482957013642 putative cosubstrate binding site; other site 482957013643 catalytic site [active] 482957013644 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 482957013645 substrate binding site [chemical binding]; other site 482957013646 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 482957013647 active site 482957013648 catalytic residues [active] 482957013649 metal binding site [ion binding]; metal-binding site 482957013650 DNA protecting protein DprA; Region: dprA; TIGR00732 482957013651 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 482957013652 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 482957013653 catalytic residues [active] 482957013654 DNA topoisomerase III; Validated; Region: PRK08173 482957013655 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 482957013656 active site 482957013657 putative interdomain interaction site [polypeptide binding]; other site 482957013658 putative metal-binding site [ion binding]; other site 482957013659 putative nucleotide binding site [chemical binding]; other site 482957013660 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 482957013661 domain I; other site 482957013662 DNA binding groove [nucleotide binding] 482957013663 phosphate binding site [ion binding]; other site 482957013664 domain II; other site 482957013665 domain III; other site 482957013666 nucleotide binding site [chemical binding]; other site 482957013667 catalytic site [active] 482957013668 domain IV; other site 482957013669 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 482957013670 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 482957013671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957013672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013673 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957013674 putative effector binding pocket; other site 482957013675 dimerization interface [polypeptide binding]; other site 482957013676 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 482957013677 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 482957013678 dimerization interface [polypeptide binding]; other site 482957013679 NAD binding site [chemical binding]; other site 482957013680 ligand binding site [chemical binding]; other site 482957013681 catalytic site [active] 482957013682 Patatin-like phospholipase; Region: Patatin; pfam01734 482957013683 active site 482957013684 nucleophile elbow; other site 482957013685 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 482957013686 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 482957013687 CoenzymeA binding site [chemical binding]; other site 482957013688 subunit interaction site [polypeptide binding]; other site 482957013689 PHB binding site; other site 482957013690 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 482957013691 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 482957013692 CGNR zinc finger; Region: zf-CGNR; pfam11706 482957013693 haloalkane dehalogenase; Provisional; Region: PRK03592 482957013694 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 482957013695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957013696 Walker A/P-loop; other site 482957013697 ATP binding site [chemical binding]; other site 482957013698 Q-loop/lid; other site 482957013699 ABC transporter signature motif; other site 482957013700 Walker B; other site 482957013701 D-loop; other site 482957013702 H-loop/switch region; other site 482957013703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957013704 dimer interface [polypeptide binding]; other site 482957013705 conserved gate region; other site 482957013706 putative PBP binding loops; other site 482957013707 ABC-ATPase subunit interface; other site 482957013708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957013709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957013710 substrate binding pocket [chemical binding]; other site 482957013711 membrane-bound complex binding site; other site 482957013712 hinge residues; other site 482957013713 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 482957013714 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 482957013715 NAD(P) binding site [chemical binding]; other site 482957013716 catalytic residues [active] 482957013717 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 482957013718 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 482957013719 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 482957013720 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 482957013721 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 482957013722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957013723 Walker A/P-loop; other site 482957013724 ATP binding site [chemical binding]; other site 482957013725 Q-loop/lid; other site 482957013726 ABC transporter signature motif; other site 482957013727 Walker B; other site 482957013728 D-loop; other site 482957013729 H-loop/switch region; other site 482957013730 TOBE domain; Region: TOBE_2; pfam08402 482957013731 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 482957013732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957013733 dimer interface [polypeptide binding]; other site 482957013734 conserved gate region; other site 482957013735 putative PBP binding loops; other site 482957013736 ABC-ATPase subunit interface; other site 482957013737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957013738 dimer interface [polypeptide binding]; other site 482957013739 conserved gate region; other site 482957013740 putative PBP binding loops; other site 482957013741 ABC-ATPase subunit interface; other site 482957013742 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 482957013743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957013744 catalytic residue [active] 482957013745 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957013746 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957013747 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 482957013748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957013749 DNA-binding site [nucleotide binding]; DNA binding site 482957013750 FCD domain; Region: FCD; pfam07729 482957013751 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957013752 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957013753 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957013754 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957013755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013756 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 482957013757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957013758 dimerization interface [polypeptide binding]; other site 482957013759 L-lactate permease; Region: Lactate_perm; cl00701 482957013760 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 482957013761 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957013762 glutamate--cysteine ligase; Provisional; Region: PRK02107 482957013763 AlkA N-terminal domain; Region: AlkA_N; pfam06029 482957013764 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 482957013765 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 482957013766 minor groove reading motif; other site 482957013767 helix-hairpin-helix signature motif; other site 482957013768 substrate binding pocket [chemical binding]; other site 482957013769 active site 482957013770 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 482957013771 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 482957013772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957013773 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 482957013774 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 482957013775 DNA binding site [nucleotide binding] 482957013776 active site 482957013777 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 482957013778 dimer interface [polypeptide binding]; other site 482957013779 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957013780 metal binding site [ion binding]; metal-binding site 482957013781 YaeQ protein; Region: YaeQ; pfam07152 482957013782 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 482957013783 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957013784 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 482957013785 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957013786 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957013787 metal binding site [ion binding]; metal-binding site 482957013788 active site 482957013789 I-site; other site 482957013790 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 482957013791 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 482957013792 trmE is a tRNA modification GTPase; Region: trmE; cd04164 482957013793 G1 box; other site 482957013794 GTP/Mg2+ binding site [chemical binding]; other site 482957013795 Switch I region; other site 482957013796 G2 box; other site 482957013797 Switch II region; other site 482957013798 G3 box; other site 482957013799 G4 box; other site 482957013800 G5 box; other site 482957013801 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 482957013802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957013803 non-specific DNA binding site [nucleotide binding]; other site 482957013804 salt bridge; other site 482957013805 sequence-specific DNA binding site [nucleotide binding]; other site 482957013806 membrane protein insertase; Provisional; Region: PRK01318 482957013807 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 482957013808 hypothetical protein; Validated; Region: PRK00041 482957013809 Ribonuclease P; Region: Ribonuclease_P; cl00457 482957013810 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 482957013811 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 482957013812 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 482957013813 active site 482957013814 catalytic residues [active] 482957013815 Int/Topo IB signature motif; other site 482957013816 DNA binding site [nucleotide binding] 482957013817 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 482957013818 Initiator Replication protein; Region: Rep_3; pfam01051 482957013819 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 482957013820 ParB-like nuclease domain; Region: ParB; smart00470 482957013821 ParA-like protein; Provisional; Region: PHA02518 482957013822 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957013823 P-loop; other site 482957013824 Magnesium ion binding site [ion binding]; other site 482957013825 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 482957013826 ArsC family; Region: ArsC; pfam03960 482957013827 catalytic residues [active] 482957013828 Putative zinc-finger; Region: zf-HC2; pfam13490 482957013829 RNA polymerase sigma factor; Provisional; Region: PRK12545 482957013830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957013831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 482957013832 DNA binding residues [nucleotide binding] 482957013833 Predicted flavoprotein [General function prediction only]; Region: COG0431 482957013834 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957013835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957013836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957013837 dimer interface [polypeptide binding]; other site 482957013838 phosphorylation site [posttranslational modification] 482957013839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957013840 ATP binding site [chemical binding]; other site 482957013841 Mg2+ binding site [ion binding]; other site 482957013842 G-X-G motif; other site 482957013843 Response regulator receiver domain; Region: Response_reg; pfam00072 482957013844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957013845 active site 482957013846 phosphorylation site [posttranslational modification] 482957013847 intermolecular recognition site; other site 482957013848 dimerization interface [polypeptide binding]; other site 482957013849 Response regulator receiver domain; Region: Response_reg; pfam00072 482957013850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957013851 active site 482957013852 phosphorylation site [posttranslational modification] 482957013853 intermolecular recognition site; other site 482957013854 dimerization interface [polypeptide binding]; other site 482957013855 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 482957013856 PAS fold; Region: PAS_4; pfam08448 482957013857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957013858 putative active site [active] 482957013859 heme pocket [chemical binding]; other site 482957013860 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957013861 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957013862 metal binding site [ion binding]; metal-binding site 482957013863 active site 482957013864 I-site; other site 482957013865 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 482957013866 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957013867 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 482957013868 active site lid residues [active] 482957013869 substrate binding pocket [chemical binding]; other site 482957013870 catalytic residues [active] 482957013871 substrate-Mg2+ binding site; other site 482957013872 aspartate-rich region 1; other site 482957013873 aspartate-rich region 2; other site 482957013874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957013875 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 482957013876 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 482957013877 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 482957013878 Active site cavity [active] 482957013879 catalytic acid [active] 482957013880 hypothetical protein; Provisional; Region: PRK07077 482957013881 VacJ like lipoprotein; Region: VacJ; cl01073 482957013882 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 482957013883 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 482957013884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957013885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957013886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957013887 putative substrate translocation pore; other site 482957013888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957013889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957013890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957013891 active site 482957013892 phosphorylation site [posttranslational modification] 482957013893 intermolecular recognition site; other site 482957013894 dimerization interface [polypeptide binding]; other site 482957013895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957013896 DNA binding residues [nucleotide binding] 482957013897 dimerization interface [polypeptide binding]; other site 482957013898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 482957013899 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 482957013900 Histidine kinase; Region: HisKA_3; pfam07730 482957013901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957013902 ATP binding site [chemical binding]; other site 482957013903 Mg2+ binding site [ion binding]; other site 482957013904 G-X-G motif; other site 482957013905 Cache domain; Region: Cache_1; pfam02743 482957013906 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957013907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957013908 metal binding site [ion binding]; metal-binding site 482957013909 active site 482957013910 I-site; other site 482957013911 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 482957013912 active site 482957013913 Domain of unknown function (DUF336); Region: DUF336; cl01249 482957013914 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 482957013915 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 482957013916 Cysteine-rich domain; Region: CCG; pfam02754 482957013917 Cysteine-rich domain; Region: CCG; pfam02754 482957013918 FAD binding domain; Region: FAD_binding_4; pfam01565 482957013919 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 482957013920 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 482957013921 FAD binding domain; Region: FAD_binding_4; pfam01565 482957013922 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 482957013923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957013924 DNA-binding site [nucleotide binding]; DNA binding site 482957013925 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957013926 Transcriptional regulators [Transcription]; Region: GntR; COG1802 482957013927 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957013928 DNA-binding site [nucleotide binding]; DNA binding site 482957013929 FCD domain; Region: FCD; pfam07729 482957013930 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 482957013931 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957013932 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 482957013933 C-terminal domain interface [polypeptide binding]; other site 482957013934 GSH binding site (G-site) [chemical binding]; other site 482957013935 dimer interface [polypeptide binding]; other site 482957013936 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 482957013937 dimer interface [polypeptide binding]; other site 482957013938 N-terminal domain interface [polypeptide binding]; other site 482957013939 substrate binding pocket (H-site) [chemical binding]; other site 482957013940 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 482957013941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957013942 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 482957013943 putative dimerization interface [polypeptide binding]; other site 482957013944 dihydroxy-acid dehydratase; Validated; Region: PRK06131 482957013945 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957013946 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 482957013947 inhibitor site; inhibition site 482957013948 active site 482957013949 dimer interface [polypeptide binding]; other site 482957013950 catalytic residue [active] 482957013951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 482957013952 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 482957013953 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 482957013954 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 482957013955 ligand binding site [chemical binding]; other site 482957013956 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 482957013957 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957013958 Walker A/P-loop; other site 482957013959 ATP binding site [chemical binding]; other site 482957013960 Q-loop/lid; other site 482957013961 ABC transporter signature motif; other site 482957013962 Walker B; other site 482957013963 D-loop; other site 482957013964 H-loop/switch region; other site 482957013965 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957013966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957013967 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957013968 TM-ABC transporter signature motif; other site 482957013969 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 482957013970 MarR family; Region: MarR_2; cl17246 482957013971 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957013972 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 482957013973 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957013974 substrate binding site [chemical binding]; other site 482957013975 oxyanion hole (OAH) forming residues; other site 482957013976 trimer interface [polypeptide binding]; other site 482957013977 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957013978 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 482957013979 NAD(P) binding site [chemical binding]; other site 482957013980 catalytic residues [active] 482957013981 feruloyl-CoA synthase; Reviewed; Region: PRK08180 482957013982 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 482957013983 acyl-activating enzyme (AAE) consensus motif; other site 482957013984 putative AMP binding site [chemical binding]; other site 482957013985 putative active site [active] 482957013986 putative CoA binding site [chemical binding]; other site 482957013987 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 482957013988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957013989 putative substrate translocation pore; other site 482957013990 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957013991 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957013992 trimer interface [polypeptide binding]; other site 482957013993 eyelet of channel; other site 482957013994 Tannase and feruloyl esterase; Region: Tannase; pfam07519 482957013995 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957013996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957013997 putative DNA binding site [nucleotide binding]; other site 482957013998 putative Zn2+ binding site [ion binding]; other site 482957013999 AsnC family; Region: AsnC_trans_reg; pfam01037 482957014000 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 482957014001 catalytic residue [active] 482957014002 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957014003 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957014004 metal binding site [ion binding]; metal-binding site 482957014005 putative dimer interface [polypeptide binding]; other site 482957014006 aminotransferase; Validated; Region: PRK07046 482957014007 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957014008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957014009 catalytic residue [active] 482957014010 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 482957014011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957014012 Coenzyme A binding pocket [chemical binding]; other site 482957014013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957014014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957014015 non-specific DNA binding site [nucleotide binding]; other site 482957014016 salt bridge; other site 482957014017 sequence-specific DNA binding site [nucleotide binding]; other site 482957014018 Cupin domain; Region: Cupin_2; pfam07883 482957014019 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 482957014020 homotrimer interaction site [polypeptide binding]; other site 482957014021 putative active site [active] 482957014022 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957014023 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957014024 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957014025 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 482957014026 Spore germination protein; Region: Spore_permease; cl17796 482957014027 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 482957014028 cytosine deaminase; Provisional; Region: PRK05985 482957014029 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 482957014030 active site 482957014031 cytosine deaminase; Provisional; Region: PRK05985 482957014032 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 482957014033 active site 482957014034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 482957014035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014037 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957014038 dimerization interface [polypeptide binding]; other site 482957014039 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 482957014040 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 482957014041 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957014042 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957014043 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 482957014044 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 482957014045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957014046 substrate binding pocket [chemical binding]; other site 482957014047 membrane-bound complex binding site; other site 482957014048 hinge residues; other site 482957014049 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 482957014050 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 482957014051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957014052 DNA-binding site [nucleotide binding]; DNA binding site 482957014053 UTRA domain; Region: UTRA; pfam07702 482957014054 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957014055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957014056 non-specific DNA binding site [nucleotide binding]; other site 482957014057 salt bridge; other site 482957014058 sequence-specific DNA binding site [nucleotide binding]; other site 482957014059 Cupin domain; Region: Cupin_2; pfam07883 482957014060 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 482957014061 intersubunit interface [polypeptide binding]; other site 482957014062 active site 482957014063 Zn2+ binding site [ion binding]; other site 482957014064 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957014065 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 482957014066 inhibitor site; inhibition site 482957014067 active site 482957014068 dimer interface [polypeptide binding]; other site 482957014069 catalytic residue [active] 482957014070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 482957014071 MOSC domain; Region: MOSC; pfam03473 482957014072 3-alpha domain; Region: 3-alpha; pfam03475 482957014073 short chain dehydrogenase; Provisional; Region: PRK07023 482957014074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957014075 NAD(P) binding site [chemical binding]; other site 482957014076 active site 482957014077 hypothetical protein; Provisional; Region: PRK11239 482957014078 Protein of unknown function, DUF480; Region: DUF480; pfam04337 482957014079 Secretory lipase; Region: LIP; pfam03583 482957014080 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 482957014081 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 482957014082 PRC-barrel domain; Region: PRC; pfam05239 482957014083 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 482957014084 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 482957014085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957014086 NAD(P) binding site [chemical binding]; other site 482957014087 active site 482957014088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014090 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957014091 putative effector binding pocket; other site 482957014092 dimerization interface [polypeptide binding]; other site 482957014093 Cupin domain; Region: Cupin_2; pfam07883 482957014094 Uncharacterized conserved protein [Function unknown]; Region: COG2128 482957014095 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957014096 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 482957014097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957014098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957014099 DNA binding residues [nucleotide binding] 482957014100 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 482957014101 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 482957014102 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 482957014103 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 482957014104 amino acid carrier protein; Region: agcS; TIGR00835 482957014105 carbon starvation protein A; Provisional; Region: PRK15015 482957014106 Carbon starvation protein CstA; Region: CstA; pfam02554 482957014107 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 482957014108 Protein of unknown function (DUF466); Region: DUF466; pfam04328 482957014109 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 482957014110 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 482957014111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957014112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014113 putative substrate translocation pore; other site 482957014114 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957014115 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 482957014116 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957014117 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 482957014118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 482957014119 FeS/SAM binding site; other site 482957014120 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 482957014121 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 482957014122 LytB protein; Region: LYTB; pfam02401 482957014123 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 482957014124 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 482957014125 active site 482957014126 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 482957014127 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 482957014128 putative NADP binding site [chemical binding]; other site 482957014129 putative substrate binding site [chemical binding]; other site 482957014130 active site 482957014131 acylphosphatase; Provisional; Region: PRK14424 482957014132 Predicted permeases [General function prediction only]; Region: RarD; COG2962 482957014133 OpgC protein; Region: OpgC_C; pfam10129 482957014134 Acyltransferase family; Region: Acyl_transf_3; pfam01757 482957014135 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 482957014136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014137 putative substrate translocation pore; other site 482957014138 POT family; Region: PTR2; cl17359 482957014139 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 482957014140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957014141 non-specific DNA binding site [nucleotide binding]; other site 482957014142 salt bridge; other site 482957014143 sequence-specific DNA binding site [nucleotide binding]; other site 482957014144 Cupin domain; Region: Cupin_2; pfam07883 482957014145 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 482957014146 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 482957014147 peptide binding site [polypeptide binding]; other site 482957014148 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 482957014149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957014150 dimer interface [polypeptide binding]; other site 482957014151 conserved gate region; other site 482957014152 putative PBP binding loops; other site 482957014153 ABC-ATPase subunit interface; other site 482957014154 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 482957014155 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 482957014156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957014157 dimer interface [polypeptide binding]; other site 482957014158 conserved gate region; other site 482957014159 putative PBP binding loops; other site 482957014160 ABC-ATPase subunit interface; other site 482957014161 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 482957014162 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957014163 Walker A/P-loop; other site 482957014164 ATP binding site [chemical binding]; other site 482957014165 Q-loop/lid; other site 482957014166 ABC transporter signature motif; other site 482957014167 Walker B; other site 482957014168 D-loop; other site 482957014169 H-loop/switch region; other site 482957014170 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957014171 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 482957014172 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957014173 Walker A/P-loop; other site 482957014174 ATP binding site [chemical binding]; other site 482957014175 Q-loop/lid; other site 482957014176 ABC transporter signature motif; other site 482957014177 Walker B; other site 482957014178 D-loop; other site 482957014179 H-loop/switch region; other site 482957014180 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957014181 outer membrane porin, OprD family; Region: OprD; pfam03573 482957014182 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 482957014183 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 482957014184 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 482957014185 active site residue [active] 482957014186 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957014187 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957014188 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957014189 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957014190 putative acetyltransferase YhhY; Provisional; Region: PRK10140 482957014191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957014192 Coenzyme A binding pocket [chemical binding]; other site 482957014193 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 482957014194 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957014195 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 482957014196 putative substrate binding pocket [chemical binding]; other site 482957014197 trimer interface [polypeptide binding]; other site 482957014198 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957014199 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 482957014200 PAS fold; Region: PAS_4; pfam08448 482957014201 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 482957014202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957014203 Walker B motif; other site 482957014204 arginine finger; other site 482957014205 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957014206 H-NS histone family; Region: Histone_HNS; pfam00816 482957014207 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957014208 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 482957014209 CoA binding domain; Region: CoA_binding_2; pfam13380 482957014210 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 482957014211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957014212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957014213 Coenzyme A binding pocket [chemical binding]; other site 482957014214 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957014215 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 482957014216 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957014217 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 482957014218 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957014219 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 482957014220 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957014221 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 482957014222 CGNR zinc finger; Region: zf-CGNR; pfam11706 482957014223 Propionate catabolism activator; Region: PrpR_N; pfam06506 482957014224 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 482957014225 PAS domain; Region: PAS; smart00091 482957014226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957014227 Walker A motif; other site 482957014228 ATP binding site [chemical binding]; other site 482957014229 Walker B motif; other site 482957014230 arginine finger; other site 482957014231 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 482957014232 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 482957014233 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 482957014234 tetramer interface [polypeptide binding]; other site 482957014235 active site 482957014236 Mg2+/Mn2+ binding site [ion binding]; other site 482957014237 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 482957014238 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 482957014239 dimer interface [polypeptide binding]; other site 482957014240 active site 482957014241 citrylCoA binding site [chemical binding]; other site 482957014242 oxalacetate/citrate binding site [chemical binding]; other site 482957014243 coenzyme A binding site [chemical binding]; other site 482957014244 catalytic triad [active] 482957014245 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 482957014246 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 482957014247 substrate binding site [chemical binding]; other site 482957014248 ligand binding site [chemical binding]; other site 482957014249 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 482957014250 substrate binding site [chemical binding]; other site 482957014251 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 482957014252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957014253 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957014254 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957014255 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957014256 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957014257 active site 482957014258 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 482957014259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014260 putative substrate translocation pore; other site 482957014261 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957014262 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957014263 trimer interface [polypeptide binding]; other site 482957014264 eyelet of channel; other site 482957014265 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 482957014266 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957014267 substrate binding site [chemical binding]; other site 482957014268 oxyanion hole (OAH) forming residues; other site 482957014269 trimer interface [polypeptide binding]; other site 482957014270 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957014271 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957014272 enoyl-CoA hydratase; Provisional; Region: PRK09245 482957014273 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957014274 substrate binding site [chemical binding]; other site 482957014275 oxyanion hole (OAH) forming residues; other site 482957014276 trimer interface [polypeptide binding]; other site 482957014277 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 482957014278 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957014279 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957014280 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957014281 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 482957014282 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 482957014283 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 482957014284 CoenzymeA binding site [chemical binding]; other site 482957014285 subunit interaction site [polypeptide binding]; other site 482957014286 PHB binding site; other site 482957014287 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 482957014288 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 482957014289 dimer interface [polypeptide binding]; other site 482957014290 ligand binding site [chemical binding]; other site 482957014291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957014292 dimer interface [polypeptide binding]; other site 482957014293 putative CheW interface [polypeptide binding]; other site 482957014294 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 482957014295 putative active cleft [active] 482957014296 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957014297 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957014298 Coenzyme A binding pocket [chemical binding]; other site 482957014299 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 482957014300 metal-binding site [ion binding] 482957014301 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 482957014302 metal-binding site [ion binding] 482957014303 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 482957014304 metal-binding site [ion binding] 482957014305 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 482957014306 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 482957014307 metal-binding site [ion binding] 482957014308 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 482957014309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957014310 motif II; other site 482957014311 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 482957014312 HicB family; Region: HicB; pfam05534 482957014313 Uncharacterized conserved protein [Function unknown]; Region: COG5361 482957014314 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 482957014315 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 482957014316 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 482957014317 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 482957014318 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 482957014319 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 482957014320 Sulfatase; Region: Sulfatase; cl17466 482957014321 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957014322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014323 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957014324 dimerization interface [polypeptide binding]; other site 482957014325 substrate binding pocket [chemical binding]; other site 482957014326 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 482957014327 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 482957014328 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 482957014329 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 482957014330 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 482957014331 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 482957014332 tetramer interface [polypeptide binding]; other site 482957014333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957014334 catalytic residue [active] 482957014335 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 482957014336 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 482957014337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014338 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 482957014339 putative dimerization interface [polypeptide binding]; other site 482957014340 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 482957014341 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 482957014342 dimer interface [polypeptide binding]; other site 482957014343 decamer (pentamer of dimers) interface [polypeptide binding]; other site 482957014344 catalytic triad [active] 482957014345 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 482957014346 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 482957014347 active site residue [active] 482957014348 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957014349 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 482957014350 C-terminal domain interface [polypeptide binding]; other site 482957014351 GSH binding site (G-site) [chemical binding]; other site 482957014352 dimer interface [polypeptide binding]; other site 482957014353 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 482957014354 dimer interface [polypeptide binding]; other site 482957014355 N-terminal domain interface [polypeptide binding]; other site 482957014356 substrate binding pocket (H-site) [chemical binding]; other site 482957014357 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 482957014358 active site 482957014359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957014361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014363 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957014364 putative effector binding pocket; other site 482957014365 dimerization interface [polypeptide binding]; other site 482957014366 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 482957014367 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 482957014368 putative catalytic residue [active] 482957014369 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 482957014370 putative hydrophobic ligand binding site [chemical binding]; other site 482957014371 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 482957014372 putative hydrophobic ligand binding site [chemical binding]; other site 482957014373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957014374 dimerization interface [polypeptide binding]; other site 482957014375 putative DNA binding site [nucleotide binding]; other site 482957014376 putative Zn2+ binding site [ion binding]; other site 482957014377 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957014378 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 482957014379 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 482957014380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957014381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957014382 short chain dehydrogenase; Validated; Region: PRK08264 482957014383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957014384 NAD(P) binding site [chemical binding]; other site 482957014385 active site 482957014386 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 482957014387 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 482957014388 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 482957014389 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 482957014390 Predicted transcriptional regulators [Transcription]; Region: COG1510 482957014391 MarR family; Region: MarR_2; pfam12802 482957014392 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 482957014393 NADH(P)-binding; Region: NAD_binding_10; pfam13460 482957014394 putative NAD(P) binding site [chemical binding]; other site 482957014395 active site 482957014396 DoxX-like family; Region: DoxX_3; pfam13781 482957014397 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 482957014398 Protein of unknown function, DUF393; Region: DUF393; pfam04134 482957014399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957014400 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 482957014401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957014402 NAD(P) binding site [chemical binding]; other site 482957014403 active site 482957014404 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957014405 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 482957014406 putative C-terminal domain interface [polypeptide binding]; other site 482957014407 putative GSH binding site (G-site) [chemical binding]; other site 482957014408 putative dimer interface [polypeptide binding]; other site 482957014409 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 482957014410 putative N-terminal domain interface [polypeptide binding]; other site 482957014411 putative dimer interface [polypeptide binding]; other site 482957014412 putative substrate binding pocket (H-site) [chemical binding]; other site 482957014413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957014414 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957014415 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 482957014416 HIT family signature motif; other site 482957014417 catalytic residue [active] 482957014418 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 482957014419 hypothetical protein; Provisional; Region: PRK11171 482957014420 Cupin domain; Region: Cupin_2; pfam07883 482957014421 Cupin domain; Region: Cupin_2; pfam07883 482957014422 Double zinc ribbon; Region: DZR; pfam12773 482957014423 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 482957014424 Transglycosylase; Region: Transgly; pfam00912 482957014425 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 482957014426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 482957014427 Predicted membrane protein [Function unknown]; Region: COG2860 482957014428 UPF0126 domain; Region: UPF0126; pfam03458 482957014429 UPF0126 domain; Region: UPF0126; pfam03458 482957014430 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 482957014431 active site 482957014432 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 482957014433 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 482957014434 Walker A/P-loop; other site 482957014435 ATP binding site [chemical binding]; other site 482957014436 Q-loop/lid; other site 482957014437 ABC transporter signature motif; other site 482957014438 Walker B; other site 482957014439 D-loop; other site 482957014440 H-loop/switch region; other site 482957014441 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 482957014442 putative PBP binding regions; other site 482957014443 ABC-ATPase subunit interface; other site 482957014444 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 482957014445 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 482957014446 intersubunit interface [polypeptide binding]; other site 482957014447 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 482957014448 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 482957014449 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 482957014450 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 482957014451 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957014452 N-terminal plug; other site 482957014453 ligand-binding site [chemical binding]; other site 482957014454 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 482957014455 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957014456 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957014457 trimer interface [polypeptide binding]; other site 482957014458 eyelet of channel; other site 482957014459 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 482957014460 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 482957014461 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 482957014462 active site 482957014463 Zn binding site [ion binding]; other site 482957014464 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 482957014465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957014466 substrate binding pocket [chemical binding]; other site 482957014467 membrane-bound complex binding site; other site 482957014468 hinge residues; other site 482957014469 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 482957014470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014471 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957014472 dimerization interface [polypeptide binding]; other site 482957014473 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 482957014474 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957014475 conserved cys residue [active] 482957014476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957014477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957014478 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 482957014479 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 482957014480 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 482957014481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957014482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957014483 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 482957014484 Methyltransferase domain; Region: Methyltransf_24; pfam13578 482957014485 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 482957014486 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957014487 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957014488 active site 482957014489 catalytic tetrad [active] 482957014490 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957014491 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 482957014492 FMN binding site [chemical binding]; other site 482957014493 active site 482957014494 substrate binding site [chemical binding]; other site 482957014495 catalytic residue [active] 482957014496 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957014497 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957014498 active site 482957014499 catalytic tetrad [active] 482957014500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014502 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 482957014503 putative effector binding pocket; other site 482957014504 dimerization interface [polypeptide binding]; other site 482957014505 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 482957014506 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 482957014507 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 482957014508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957014509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957014510 short chain dehydrogenase; Provisional; Region: PRK06180 482957014511 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957014512 NADP binding site [chemical binding]; other site 482957014513 active site 482957014514 steroid binding site; other site 482957014515 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957014516 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957014517 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957014518 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 482957014519 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957014520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014521 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957014522 dimerization interface [polypeptide binding]; other site 482957014523 substrate binding pocket [chemical binding]; other site 482957014524 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 482957014525 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 482957014526 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 482957014527 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 482957014528 NADP binding site [chemical binding]; other site 482957014529 dimer interface [polypeptide binding]; other site 482957014530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957014531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957014532 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957014533 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957014534 metal binding site [ion binding]; metal-binding site 482957014535 putative dimer interface [polypeptide binding]; other site 482957014536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014537 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957014538 putative substrate translocation pore; other site 482957014539 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 482957014540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014541 LysR substrate binding domain; Region: LysR_substrate; pfam03466 482957014542 dimerization interface [polypeptide binding]; other site 482957014543 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 482957014544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957014545 substrate binding pocket [chemical binding]; other site 482957014546 membrane-bound complex binding site; other site 482957014547 hinge residues; other site 482957014548 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 482957014549 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 482957014550 active site 482957014551 Zn binding site [ion binding]; other site 482957014552 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 482957014553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014554 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 482957014555 substrate binding pocket [chemical binding]; other site 482957014556 dimerization interface [polypeptide binding]; other site 482957014557 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 482957014558 benzoate transport; Region: 2A0115; TIGR00895 482957014559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014560 putative substrate translocation pore; other site 482957014561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014562 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957014563 trimer interface [polypeptide binding]; other site 482957014564 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957014565 eyelet of channel; other site 482957014566 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 482957014567 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 482957014568 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 482957014569 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957014570 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957014571 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 482957014572 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957014573 dimer interface [polypeptide binding]; other site 482957014574 active site 482957014575 Uncharacterized conserved protein [Function unknown]; Region: COG1683 482957014576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957014577 Methyltransferase domain; Region: Methyltransf_31; pfam13847 482957014578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957014579 S-adenosylmethionine binding site [chemical binding]; other site 482957014580 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957014581 PAS domain; Region: PAS_9; pfam13426 482957014582 putative active site [active] 482957014583 heme pocket [chemical binding]; other site 482957014584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 482957014585 dimerization interface [polypeptide binding]; other site 482957014586 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957014587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957014588 dimer interface [polypeptide binding]; other site 482957014589 putative CheW interface [polypeptide binding]; other site 482957014590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957014591 PAS domain; Region: PAS_9; pfam13426 482957014592 putative active site [active] 482957014593 heme pocket [chemical binding]; other site 482957014594 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957014595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957014596 dimer interface [polypeptide binding]; other site 482957014597 putative CheW interface [polypeptide binding]; other site 482957014598 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 482957014599 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 482957014600 putative metal binding site [ion binding]; other site 482957014601 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 482957014602 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 482957014603 putative metal binding site [ion binding]; other site 482957014604 Integral membrane protein TerC family; Region: TerC; cl10468 482957014605 tellurite resistance protein terB; Region: terB; cd07176 482957014606 putative metal binding site [ion binding]; other site 482957014607 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 482957014608 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 482957014609 putative metal binding site [ion binding]; other site 482957014610 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 482957014611 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 482957014612 putative metal binding site [ion binding]; other site 482957014613 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 482957014614 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 482957014615 putative metal binding site [ion binding]; other site 482957014616 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 482957014617 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 482957014618 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 482957014619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957014620 active site 482957014621 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 482957014622 succinic semialdehyde dehydrogenase; Region: PLN02278 482957014623 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 482957014624 tetramerization interface [polypeptide binding]; other site 482957014625 NAD(P) binding site [chemical binding]; other site 482957014626 catalytic residues [active] 482957014627 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 482957014628 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957014629 inhibitor-cofactor binding pocket; inhibition site 482957014630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957014631 catalytic residue [active] 482957014632 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957014633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957014634 DNA-binding site [nucleotide binding]; DNA binding site 482957014635 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957014636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957014637 homodimer interface [polypeptide binding]; other site 482957014638 catalytic residue [active] 482957014639 Predicted membrane protein [Function unknown]; Region: COG1288 482957014640 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957014641 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957014642 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957014643 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 482957014644 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957014645 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957014646 trimer interface [polypeptide binding]; other site 482957014647 eyelet of channel; other site 482957014648 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 482957014649 selenophosphate synthetase; Provisional; Region: PRK00943 482957014650 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 482957014651 dimerization interface [polypeptide binding]; other site 482957014652 putative ATP binding site [chemical binding]; other site 482957014653 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957014654 Purine nucleoside permease (NUP); Region: NUP; pfam06516 482957014655 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 482957014656 putative active site [active] 482957014657 putative Zn binding site [ion binding]; other site 482957014658 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957014659 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014660 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014661 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957014662 putative effector binding pocket; other site 482957014663 putative dimerization interface [polypeptide binding]; other site 482957014664 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957014665 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957014666 substrate binding pocket [chemical binding]; other site 482957014667 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957014668 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 482957014669 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957014670 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957014671 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 482957014672 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957014673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957014674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957014675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957014678 dimerization interface [polypeptide binding]; other site 482957014679 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 482957014680 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 482957014681 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957014682 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957014683 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957014684 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957014685 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 482957014686 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957014687 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957014688 catalytic site [active] 482957014689 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 482957014690 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957014691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957014692 active site 482957014693 phosphorylation site [posttranslational modification] 482957014694 intermolecular recognition site; other site 482957014695 dimerization interface [polypeptide binding]; other site 482957014696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957014697 Walker A motif; other site 482957014698 ATP binding site [chemical binding]; other site 482957014699 Walker B motif; other site 482957014700 arginine finger; other site 482957014701 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957014702 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 482957014703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957014704 dimer interface [polypeptide binding]; other site 482957014705 phosphorylation site [posttranslational modification] 482957014706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957014707 ATP binding site [chemical binding]; other site 482957014708 Mg2+ binding site [ion binding]; other site 482957014709 G-X-G motif; other site 482957014710 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 482957014711 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 482957014712 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 482957014713 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 482957014714 active site 482957014715 non-prolyl cis peptide bond; other site 482957014716 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 482957014717 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 482957014718 Walker A/P-loop; other site 482957014719 ATP binding site [chemical binding]; other site 482957014720 Q-loop/lid; other site 482957014721 ABC transporter signature motif; other site 482957014722 Walker B; other site 482957014723 D-loop; other site 482957014724 H-loop/switch region; other site 482957014725 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 482957014726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957014727 dimer interface [polypeptide binding]; other site 482957014728 conserved gate region; other site 482957014729 ABC-ATPase subunit interface; other site 482957014730 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 482957014731 Flavin binding site [chemical binding]; other site 482957014732 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 482957014733 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 482957014734 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 482957014735 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 482957014736 putative GTP cyclohydrolase; Provisional; Region: PRK13674 482957014737 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 482957014738 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 482957014739 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 482957014740 trimer interface [polypeptide binding]; other site 482957014741 active site 482957014742 dihydroorotase; Validated; Region: PRK09060 482957014743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957014744 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 482957014745 active site 482957014746 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957014747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957014748 putative DNA binding site [nucleotide binding]; other site 482957014749 putative Zn2+ binding site [ion binding]; other site 482957014750 AsnC family; Region: AsnC_trans_reg; pfam01037 482957014751 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957014752 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 482957014753 trimer interface [polypeptide binding]; other site 482957014754 YadA-like C-terminal region; Region: YadA; pfam03895 482957014755 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957014756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957014757 non-specific DNA binding site [nucleotide binding]; other site 482957014758 salt bridge; other site 482957014759 sequence-specific DNA binding site [nucleotide binding]; other site 482957014760 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 482957014761 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 482957014762 Peptidase family M50; Region: Peptidase_M50; pfam02163 482957014763 active site 482957014764 putative substrate binding region [chemical binding]; other site 482957014765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014766 D-galactonate transporter; Region: 2A0114; TIGR00893 482957014767 putative substrate translocation pore; other site 482957014768 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 482957014769 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 482957014770 dimer interface [polypeptide binding]; other site 482957014771 NADP binding site [chemical binding]; other site 482957014772 catalytic residues [active] 482957014773 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 482957014774 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 482957014775 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957014776 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 482957014777 putative active site [active] 482957014778 catalytic residue [active] 482957014779 galactarate dehydratase; Region: galactar-dH20; TIGR03248 482957014780 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 482957014781 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 482957014782 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957014783 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 482957014784 Predicted membrane protein [Function unknown]; Region: COG2259 482957014785 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957014786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014787 putative substrate translocation pore; other site 482957014788 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957014789 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957014790 dimerization interface [polypeptide binding]; other site 482957014791 ligand binding site [chemical binding]; other site 482957014792 PAS fold; Region: PAS_4; pfam08448 482957014793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 482957014794 putative active site [active] 482957014795 heme pocket [chemical binding]; other site 482957014796 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957014797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957014798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957014799 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 482957014800 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 482957014801 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 482957014802 dimer interface [polypeptide binding]; other site 482957014803 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 482957014804 active site 482957014805 Fe binding site [ion binding]; other site 482957014806 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 482957014807 Dehydroquinase class II; Region: DHquinase_II; pfam01220 482957014808 active site 482957014809 trimer interface [polypeptide binding]; other site 482957014810 dimer interface [polypeptide binding]; other site 482957014811 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 482957014812 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 482957014813 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 482957014814 shikimate binding site; other site 482957014815 NAD(P) binding site [chemical binding]; other site 482957014816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014817 D-galactonate transporter; Region: 2A0114; TIGR00893 482957014818 putative substrate translocation pore; other site 482957014819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014820 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 482957014821 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957014822 catalytic residue [active] 482957014823 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 482957014824 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957014825 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 482957014826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957014827 Walker A/P-loop; other site 482957014828 ATP binding site [chemical binding]; other site 482957014829 Q-loop/lid; other site 482957014830 ABC transporter signature motif; other site 482957014831 Walker B; other site 482957014832 D-loop; other site 482957014833 H-loop/switch region; other site 482957014834 TOBE domain; Region: TOBE_2; pfam08402 482957014835 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 482957014836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957014837 dimer interface [polypeptide binding]; other site 482957014838 conserved gate region; other site 482957014839 putative PBP binding loops; other site 482957014840 ABC-ATPase subunit interface; other site 482957014841 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957014842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957014843 conserved gate region; other site 482957014844 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 482957014845 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 482957014846 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 482957014847 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 482957014848 NAD(P) binding site [chemical binding]; other site 482957014849 catalytic residues [active] 482957014850 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 482957014851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957014853 putative substrate translocation pore; other site 482957014854 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 482957014855 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 482957014856 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 482957014857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 482957014858 catalytic core [active] 482957014859 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 482957014860 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 482957014861 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 482957014862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014863 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 482957014864 putative dimerization interface [polypeptide binding]; other site 482957014865 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 482957014866 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 482957014867 THF binding site; other site 482957014868 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 482957014869 substrate binding site [chemical binding]; other site 482957014870 THF binding site; other site 482957014871 zinc-binding site [ion binding]; other site 482957014872 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 482957014873 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957014874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014875 putative substrate translocation pore; other site 482957014876 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 482957014877 agmatinase; Region: agmatinase; TIGR01230 482957014878 oligomer interface [polypeptide binding]; other site 482957014879 putative active site [active] 482957014880 Mn binding site [ion binding]; other site 482957014881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957014884 dimerization interface [polypeptide binding]; other site 482957014885 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957014886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957014887 putative DNA binding site [nucleotide binding]; other site 482957014888 putative Zn2+ binding site [ion binding]; other site 482957014889 AsnC family; Region: AsnC_trans_reg; pfam01037 482957014890 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957014891 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 482957014892 peptidase domain interface [polypeptide binding]; other site 482957014893 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 482957014894 active site 482957014895 catalytic triad [active] 482957014896 calcium binding site [ion binding]; other site 482957014897 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 482957014898 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 482957014899 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 482957014900 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 482957014901 homodimer interface [polypeptide binding]; other site 482957014902 NAD binding pocket [chemical binding]; other site 482957014903 ATP binding pocket [chemical binding]; other site 482957014904 Mg binding site [ion binding]; other site 482957014905 active-site loop [active] 482957014906 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 482957014907 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 482957014908 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 482957014909 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 482957014910 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 482957014911 putative active site [active] 482957014912 catalytic site [active] 482957014913 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 482957014914 putative active site [active] 482957014915 catalytic site [active] 482957014916 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957014917 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957014918 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957014919 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957014920 lysine transporter; Provisional; Region: PRK10836 482957014921 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 482957014922 aldehyde dehydrogenase family 7 member; Region: PLN02315 482957014923 tetrameric interface [polypeptide binding]; other site 482957014924 NAD binding site [chemical binding]; other site 482957014925 catalytic residues [active] 482957014926 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 482957014927 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 482957014928 Mechanosensitive ion channel; Region: MS_channel; pfam00924 482957014929 benzoate transport; Region: 2A0115; TIGR00895 482957014930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957014932 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957014933 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957014934 trimer interface [polypeptide binding]; other site 482957014935 eyelet of channel; other site 482957014936 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 482957014937 active site 482957014938 tetramer interface [polypeptide binding]; other site 482957014939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957014940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957014942 dimerization interface [polypeptide binding]; other site 482957014943 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 482957014944 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 482957014945 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957014946 active site 482957014947 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 482957014948 KWG Leptospira; Region: KWG; pfam07656 482957014949 Transglycosylase; Region: Transgly; pfam00912 482957014950 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 482957014951 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 482957014952 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957014953 EamA-like transporter family; Region: EamA; pfam00892 482957014954 EamA-like transporter family; Region: EamA; pfam00892 482957014955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957014956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957014957 dimerization interface [polypeptide binding]; other site 482957014958 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957014959 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957014960 DNA-binding site [nucleotide binding]; DNA binding site 482957014961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957014962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957014963 homodimer interface [polypeptide binding]; other site 482957014964 catalytic residue [active] 482957014965 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 482957014966 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 482957014967 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957014968 catalytic residues [active] 482957014969 osmolarity response regulator; Provisional; Region: ompR; PRK09468 482957014970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957014971 active site 482957014972 phosphorylation site [posttranslational modification] 482957014973 intermolecular recognition site; other site 482957014974 dimerization interface [polypeptide binding]; other site 482957014975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957014976 DNA binding site [nucleotide binding] 482957014977 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957014978 dimerization interface [polypeptide binding]; other site 482957014979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957014980 dimer interface [polypeptide binding]; other site 482957014981 phosphorylation site [posttranslational modification] 482957014982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957014983 ATP binding site [chemical binding]; other site 482957014984 Mg2+ binding site [ion binding]; other site 482957014985 G-X-G motif; other site 482957014986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957014987 TAP-like protein; Region: Abhydrolase_4; pfam08386 482957014988 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 482957014989 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 482957014990 active site 482957014991 metal binding site [ion binding]; metal-binding site 482957014992 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 482957014993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957014994 Coenzyme A binding pocket [chemical binding]; other site 482957014995 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957014996 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957014997 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957014998 trimer interface [polypeptide binding]; other site 482957014999 eyelet of channel; other site 482957015000 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 482957015001 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 482957015002 Cytochrome c [Energy production and conversion]; Region: COG3258 482957015003 Cytochrome c; Region: Cytochrom_C; pfam00034 482957015004 Cytochrome c; Region: Cytochrom_C; cl11414 482957015005 Cytochrome c; Region: Cytochrom_C; cl11414 482957015006 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 482957015007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957015008 substrate binding pocket [chemical binding]; other site 482957015009 membrane-bound complex binding site; other site 482957015010 hinge residues; other site 482957015011 DsrE/DsrF-like family; Region: DrsE; pfam02635 482957015012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015014 LysR substrate binding domain; Region: LysR_substrate; pfam03466 482957015015 dimerization interface [polypeptide binding]; other site 482957015016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015017 putative substrate translocation pore; other site 482957015018 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957015019 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957015020 N-terminal plug; other site 482957015021 ligand-binding site [chemical binding]; other site 482957015022 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957015023 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957015024 trimer interface [polypeptide binding]; other site 482957015025 eyelet of channel; other site 482957015026 benzoate transport; Region: 2A0115; TIGR00895 482957015027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015029 Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532 482957015030 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957015031 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 482957015032 alpha subunit interface [polypeptide binding]; other site 482957015033 active site 482957015034 substrate binding site [chemical binding]; other site 482957015035 Fe binding site [ion binding]; other site 482957015036 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957015037 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 482957015038 FMN-binding pocket [chemical binding]; other site 482957015039 flavin binding motif; other site 482957015040 phosphate binding motif [ion binding]; other site 482957015041 beta-alpha-beta structure motif; other site 482957015042 NAD binding pocket [chemical binding]; other site 482957015043 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957015044 catalytic loop [active] 482957015045 iron binding site [ion binding]; other site 482957015046 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957015047 Rieske non-heme iron oxygenase (RO) family, Vanillate-O-demethylase oxygenase (VanA) and dicamba O-demethylase oxygenase (DdmC) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating...; Region: Rieske_RO_Alpha_VanA_DdmC; cd03532 482957015048 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 482957015049 alpha subunit interface [polypeptide binding]; other site 482957015050 active site 482957015051 substrate binding site [chemical binding]; other site 482957015052 Fe binding site [ion binding]; other site 482957015053 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957015054 MarR family; Region: MarR; pfam01047 482957015055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957015056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957015057 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 482957015058 isovaleryl-CoA dehydrogenase; Region: PLN02519 482957015059 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 482957015060 substrate binding site [chemical binding]; other site 482957015061 FAD binding site [chemical binding]; other site 482957015062 catalytic base [active] 482957015063 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 482957015064 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 482957015065 enoyl-CoA hydratase; Provisional; Region: PRK05995 482957015066 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957015067 substrate binding site [chemical binding]; other site 482957015068 oxyanion hole (OAH) forming residues; other site 482957015069 trimer interface [polypeptide binding]; other site 482957015070 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 482957015071 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 482957015072 ATP-grasp domain; Region: ATP-grasp_4; cl17255 482957015073 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 482957015074 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 482957015075 carboxyltransferase (CT) interaction site; other site 482957015076 biotinylation site [posttranslational modification]; other site 482957015077 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957015078 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957015079 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957015080 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957015081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957015082 S-adenosylmethionine binding site [chemical binding]; other site 482957015083 galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288 482957015084 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 482957015085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957015086 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 482957015087 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 482957015088 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 482957015089 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 482957015090 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 482957015091 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 482957015092 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957015093 ligand binding site [chemical binding]; other site 482957015094 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 482957015095 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 482957015096 trimer interface [polypeptide binding]; other site 482957015097 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 482957015098 trimer interface [polypeptide binding]; other site 482957015099 YadA-like C-terminal region; Region: YadA; pfam03895 482957015100 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 482957015101 possible frameshift; similar to NADPH-dependent FMN reductase 482957015102 possible frameshift; hypothetical protein 482957015103 NIPSNAP; Region: NIPSNAP; pfam07978 482957015104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957015105 Coenzyme A binding pocket [chemical binding]; other site 482957015106 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 482957015107 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 482957015108 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 482957015109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957015110 active site 482957015111 phosphorylation site [posttranslational modification] 482957015112 intermolecular recognition site; other site 482957015113 dimerization interface [polypeptide binding]; other site 482957015114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957015115 DNA binding site [nucleotide binding] 482957015116 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957015117 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957015118 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957015119 catalytic residue [active] 482957015120 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 482957015121 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 482957015122 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 482957015123 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 482957015124 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 482957015125 Walker A/P-loop; other site 482957015126 ATP binding site [chemical binding]; other site 482957015127 Q-loop/lid; other site 482957015128 ABC transporter signature motif; other site 482957015129 Walker B; other site 482957015130 D-loop; other site 482957015131 H-loop/switch region; other site 482957015132 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 482957015133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957015134 dimer interface [polypeptide binding]; other site 482957015135 conserved gate region; other site 482957015136 putative PBP binding loops; other site 482957015137 ABC-ATPase subunit interface; other site 482957015138 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957015139 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 482957015140 conserved cys residue [active] 482957015141 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 482957015142 metal binding site [ion binding]; metal-binding site 482957015143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015144 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957015145 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 482957015146 Bacterial transcriptional activator domain; Region: BTAD; smart01043 482957015147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957015148 TPR motif; other site 482957015149 binding surface 482957015150 Predicted membrane protein [Function unknown]; Region: COG4125 482957015151 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 482957015152 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 482957015153 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957015154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957015156 dimerization interface [polypeptide binding]; other site 482957015157 VPS10 domain; Region: VPS10; smart00602 482957015158 Ubiquitin-like proteins; Region: UBQ; cl00155 482957015159 charged pocket; other site 482957015160 hydrophobic patch; other site 482957015161 ASCH domain; Region: ASCH; pfam04266 482957015162 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 482957015163 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957015164 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957015165 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 482957015166 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 482957015167 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 482957015168 ligand binding site; other site 482957015169 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 482957015170 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957015171 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 482957015172 putative NAD(P) binding site [chemical binding]; other site 482957015173 active site 482957015174 putative substrate binding site [chemical binding]; other site 482957015175 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 482957015176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015177 D-galactonate transporter; Region: 2A0114; TIGR00893 482957015178 putative substrate translocation pore; other site 482957015179 putative aldolase; Validated; Region: PRK08130 482957015180 intersubunit interface [polypeptide binding]; other site 482957015181 active site 482957015182 Zn2+ binding site [ion binding]; other site 482957015183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 482957015184 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957015185 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957015186 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957015187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957015188 DNA-binding site [nucleotide binding]; DNA binding site 482957015189 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957015190 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957015191 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957015192 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957015193 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957015194 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957015195 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957015196 eyelet of channel; other site 482957015197 trimer interface [polypeptide binding]; other site 482957015198 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 482957015199 Sulfatase; Region: Sulfatase; cl17466 482957015200 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957015201 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 482957015202 conserved cys residue [active] 482957015203 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 482957015204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015205 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 482957015206 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 482957015207 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 482957015208 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 482957015209 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957015210 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 482957015211 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 482957015212 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 482957015213 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 482957015214 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 482957015215 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 482957015216 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 482957015217 active site 482957015218 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957015219 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 482957015220 FMN binding site [chemical binding]; other site 482957015221 active site 482957015222 substrate binding site [chemical binding]; other site 482957015223 catalytic residue [active] 482957015224 LysR family transcriptional regulator; Provisional; Region: PRK14997 482957015225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015226 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957015227 putative effector binding pocket; other site 482957015228 dimerization interface [polypeptide binding]; other site 482957015229 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 482957015230 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957015231 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957015232 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957015233 catalytic residue [active] 482957015234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957015235 ABC-ATPase subunit interface; other site 482957015236 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 482957015237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957015238 Walker A/P-loop; other site 482957015239 ATP binding site [chemical binding]; other site 482957015240 Q-loop/lid; other site 482957015241 ABC transporter signature motif; other site 482957015242 Walker B; other site 482957015243 D-loop; other site 482957015244 H-loop/switch region; other site 482957015245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957015246 dimer interface [polypeptide binding]; other site 482957015247 conserved gate region; other site 482957015248 putative PBP binding loops; other site 482957015249 ABC-ATPase subunit interface; other site 482957015250 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 482957015251 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 482957015252 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 482957015253 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 482957015254 putative ligand binding site [chemical binding]; other site 482957015255 NAD binding site [chemical binding]; other site 482957015256 catalytic site [active] 482957015257 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957015258 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 482957015259 NAD(P) binding site [chemical binding]; other site 482957015260 DoxX; Region: DoxX; pfam07681 482957015261 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957015262 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 482957015263 FMN binding site [chemical binding]; other site 482957015264 active site 482957015265 substrate binding site [chemical binding]; other site 482957015266 catalytic residue [active] 482957015267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015269 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957015270 dimerization interface [polypeptide binding]; other site 482957015271 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 482957015272 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957015273 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 482957015274 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 482957015275 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 482957015276 FtsX-like permease family; Region: FtsX; pfam02687 482957015277 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 482957015278 MG2 domain; Region: A2M_N; pfam01835 482957015279 Alpha-2-macroglobulin family; Region: A2M; pfam00207 482957015280 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 482957015281 surface patch; other site 482957015282 thioester region; other site 482957015283 specificity defining residues; other site 482957015284 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 482957015285 Transglycosylase; Region: Transgly; pfam00912 482957015286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 482957015287 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 482957015288 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957015289 Sel1-like repeats; Region: SEL1; smart00671 482957015290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957015292 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957015293 Colicin-E5 Imm protein; Region: ImmE5; pfam11480 482957015294 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 482957015295 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 482957015296 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 482957015297 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957015298 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957015299 active site 482957015300 catalytic tetrad [active] 482957015301 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 482957015302 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 482957015305 putative effector binding pocket; other site 482957015306 putative dimerization interface [polypeptide binding]; other site 482957015307 Predicted esterase [General function prediction only]; Region: COG0627 482957015308 S-formylglutathione hydrolase; Region: PLN02442 482957015309 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 482957015310 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957015311 catalytic site [active] 482957015312 DinB superfamily; Region: DinB_2; pfam12867 482957015313 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957015314 Serine hydrolase; Region: Ser_hydrolase; cl17834 482957015315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957015316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957015317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 482957015318 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957015319 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957015320 [2Fe-2S] cluster binding site [ion binding]; other site 482957015321 Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848 482957015322 hydrophobic ligand binding site; other site 482957015323 choline dehydrogenase; Validated; Region: PRK02106 482957015324 lycopene cyclase; Region: lycopene_cycl; TIGR01789 482957015325 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957015326 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 482957015327 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957015328 FMN-binding pocket [chemical binding]; other site 482957015329 flavin binding motif; other site 482957015330 phosphate binding motif [ion binding]; other site 482957015331 beta-alpha-beta structure motif; other site 482957015332 NAD binding pocket [chemical binding]; other site 482957015333 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957015334 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 482957015335 catalytic loop [active] 482957015336 iron binding site [ion binding]; other site 482957015337 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 482957015338 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957015339 short chain dehydrogenase; Provisional; Region: PRK06138 482957015340 classical (c) SDRs; Region: SDR_c; cd05233 482957015341 NAD(P) binding site [chemical binding]; other site 482957015342 active site 482957015343 hypothetical protein; Provisional; Region: PRK07490 482957015344 active site 482957015345 intersubunit interface [polypeptide binding]; other site 482957015346 Zn2+ binding site [ion binding]; other site 482957015347 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 482957015348 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957015349 tetramerization interface [polypeptide binding]; other site 482957015350 NAD(P) binding site [chemical binding]; other site 482957015351 catalytic residues [active] 482957015352 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 482957015353 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957015354 conserved cys residue [active] 482957015355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015356 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 482957015357 benzoate transport; Region: 2A0115; TIGR00895 482957015358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015359 putative substrate translocation pore; other site 482957015360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015361 ABC-2 type transporter; Region: ABC2_membrane; cl17235 482957015362 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 482957015363 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 482957015364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 482957015365 Walker A/P-loop; other site 482957015366 ATP binding site [chemical binding]; other site 482957015367 Q-loop/lid; other site 482957015368 ABC transporter signature motif; other site 482957015369 Walker B; other site 482957015370 D-loop; other site 482957015371 H-loop/switch region; other site 482957015372 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 482957015373 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 482957015374 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 482957015375 PGF-pre-PGF domain; Region: PGF_pre_PGF; TIGR04213 482957015376 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 482957015377 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 482957015378 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957015379 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 482957015380 active site 482957015381 catalytic residues [active] 482957015382 choline dehydrogenase; Validated; Region: PRK02106 482957015383 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957015384 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 482957015385 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 482957015386 tetrameric interface [polypeptide binding]; other site 482957015387 NAD binding site [chemical binding]; other site 482957015388 catalytic residues [active] 482957015389 transcriptional regulator BetI; Validated; Region: PRK00767 482957015390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957015391 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 482957015392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957015393 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 482957015394 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 482957015395 active site 482957015396 TDP-binding site; other site 482957015397 acceptor substrate-binding pocket; other site 482957015398 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957015399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015400 putative substrate translocation pore; other site 482957015401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015402 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 482957015403 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 482957015404 Ligand binding site; other site 482957015405 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957015406 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 482957015407 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957015408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957015409 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 482957015410 NAD(P) binding site [chemical binding]; other site 482957015411 active site 482957015412 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 482957015413 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 482957015414 NAD binding site [chemical binding]; other site 482957015415 catalytic Zn binding site [ion binding]; other site 482957015416 structural Zn binding site [ion binding]; other site 482957015417 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 482957015418 active site 482957015419 intersubunit interface [polypeptide binding]; other site 482957015420 catalytic residue [active] 482957015421 Predicted ATP-dependent serine protease [Posttranslational modification, protein turnover, chaperones]; Region: Sms; COG1066 482957015422 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957015423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957015424 DNA-binding site [nucleotide binding]; DNA binding site 482957015425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957015426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957015427 homodimer interface [polypeptide binding]; other site 482957015428 catalytic residue [active] 482957015429 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 482957015430 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 482957015431 sugar binding site [chemical binding]; other site 482957015432 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957015433 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 482957015434 conserved cys residue [active] 482957015435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015436 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 482957015437 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 482957015438 dimer interface [polypeptide binding]; other site 482957015439 active site 482957015440 glycine-pyridoxal phosphate binding site [chemical binding]; other site 482957015441 folate binding site [chemical binding]; other site 482957015442 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 482957015443 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 482957015444 active site 482957015445 dimer interface [polypeptide binding]; other site 482957015446 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 482957015447 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 482957015448 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 482957015449 putative active site [active] 482957015450 putative FMN binding site [chemical binding]; other site 482957015451 putative substrate binding site [chemical binding]; other site 482957015452 putative catalytic residue [active] 482957015453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957015454 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 482957015455 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 482957015456 4Fe-4S binding domain; Region: Fer4; cl02805 482957015457 Cysteine-rich domain; Region: CCG; pfam02754 482957015458 Cysteine-rich domain; Region: CCG; pfam02754 482957015459 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 482957015460 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 482957015461 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 482957015462 Electron transfer flavoprotein domain; Region: ETF; pfam01012 482957015463 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957015464 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957015465 [2Fe-2S] cluster binding site [ion binding]; other site 482957015466 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 482957015467 putative alpha subunit interface [polypeptide binding]; other site 482957015468 putative active site [active] 482957015469 putative substrate binding site [chemical binding]; other site 482957015470 Fe binding site [ion binding]; other site 482957015471 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957015472 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 482957015473 FAD binding pocket [chemical binding]; other site 482957015474 FAD binding motif [chemical binding]; other site 482957015475 phosphate binding motif [ion binding]; other site 482957015476 beta-alpha-beta structure motif; other site 482957015477 NAD binding pocket [chemical binding]; other site 482957015478 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 482957015479 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957015480 catalytic loop [active] 482957015481 iron binding site [ion binding]; other site 482957015482 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 482957015483 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957015484 Amino acid permease; Region: AA_permease_2; pfam13520 482957015485 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957015486 Sel1-like repeats; Region: SEL1; smart00671 482957015487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957015488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957015489 EamA-like transporter family; Region: EamA; pfam00892 482957015490 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 482957015491 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 482957015492 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 482957015493 putative active site [active] 482957015494 putative substrate binding site [chemical binding]; other site 482957015495 putative cosubstrate binding site; other site 482957015496 catalytic site [active] 482957015497 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 482957015498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015499 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957015500 dimerization interface [polypeptide binding]; other site 482957015501 substrate binding pocket [chemical binding]; other site 482957015502 choline-sulfatase; Region: chol_sulfatase; TIGR03417 482957015503 Sulfatase; Region: Sulfatase; cl17466 482957015504 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 482957015505 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 482957015506 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957015507 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957015508 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957015509 trimer interface [polypeptide binding]; other site 482957015510 eyelet of channel; other site 482957015511 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 482957015512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957015513 active site 482957015514 HIGH motif; other site 482957015515 nucleotide binding site [chemical binding]; other site 482957015516 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957015517 active site 482957015518 KMSKS motif; other site 482957015519 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 482957015520 tRNA binding surface [nucleotide binding]; other site 482957015521 anticodon binding site; other site 482957015522 enterobactin exporter EntS; Provisional; Region: PRK10489 482957015523 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 482957015524 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 482957015525 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 482957015526 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 482957015527 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 482957015528 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 482957015529 Peptidase family M28; Region: Peptidase_M28; pfam04389 482957015530 active site 482957015531 metal binding site [ion binding]; metal-binding site 482957015532 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 482957015533 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 482957015534 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 482957015535 Zn binding site [ion binding]; other site 482957015536 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957015537 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 482957015538 conserved cys residue [active] 482957015539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015540 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957015541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015542 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 482957015543 Methylamine utilisation protein MauE; Region: MauE; pfam07291 482957015544 Methylamine utilization (mau) D family; mauD protein is the translation product of the mauD gene found in methylotrophic bacteria, which are able to use methylamine as a sole carbon source and a nitrogen source. mauD is an essential accessory protein for...; Region: mauD; cd02967 482957015545 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957015546 catalytic residues [active] 482957015547 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 482957015548 Cytochrome c; Region: Cytochrom_C; pfam00034 482957015549 Cytochrome c; Region: Cytochrom_C; pfam00034 482957015550 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957015551 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957015552 NAD(P) binding site [chemical binding]; other site 482957015553 catalytic residues [active] 482957015554 Protein of unknown function, DUF606; Region: DUF606; pfam04657 482957015555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015557 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957015558 dimerization interface [polypeptide binding]; other site 482957015559 substrate binding pocket [chemical binding]; other site 482957015560 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 482957015561 tetramer interface [polypeptide binding]; other site 482957015562 active site 482957015563 Mg2+/Mn2+ binding site [ion binding]; other site 482957015564 isocitrate lyase; Region: PLN02892 482957015565 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957015566 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 482957015567 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 482957015568 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 482957015569 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957015570 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957015571 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 482957015572 active site 482957015573 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957015574 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 482957015575 Protein of unknown function (DUF971); Region: DUF971; cl01414 482957015576 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 482957015577 substrate binding pocket [chemical binding]; other site 482957015578 active site 482957015579 iron coordination sites [ion binding]; other site 482957015580 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957015581 short chain dehydrogenase; Provisional; Region: PRK06197 482957015582 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 482957015583 putative NAD(P) binding site [chemical binding]; other site 482957015584 active site 482957015585 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 482957015586 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957015587 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 482957015588 NAD binding site [chemical binding]; other site 482957015589 homotetramer interface [polypeptide binding]; other site 482957015590 homodimer interface [polypeptide binding]; other site 482957015591 active site 482957015592 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 482957015593 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957015594 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 482957015595 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 482957015596 putative active site pocket [active] 482957015597 metal binding site [ion binding]; metal-binding site 482957015598 short chain dehydrogenase; Provisional; Region: PRK08628 482957015599 classical (c) SDRs; Region: SDR_c; cd05233 482957015600 NAD(P) binding site [chemical binding]; other site 482957015601 active site 482957015602 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 482957015603 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957015604 Walker A/P-loop; other site 482957015605 ATP binding site [chemical binding]; other site 482957015606 Q-loop/lid; other site 482957015607 ABC transporter signature motif; other site 482957015608 Walker B; other site 482957015609 D-loop; other site 482957015610 H-loop/switch region; other site 482957015611 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957015612 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957015613 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957015614 TM-ABC transporter signature motif; other site 482957015615 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 482957015616 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 482957015617 putative ligand binding site [chemical binding]; other site 482957015618 Amidohydrolase; Region: Amidohydro_2; pfam04909 482957015619 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 482957015620 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957015621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957015622 DNA-binding site [nucleotide binding]; DNA binding site 482957015623 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957015624 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957015625 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957015626 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 482957015627 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 482957015628 amidohydrolase; Provisional; Region: PRK12393 482957015629 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 482957015630 active site 482957015631 putative substrate binding pocket [chemical binding]; other site 482957015632 xanthine permease; Region: pbuX; TIGR03173 482957015633 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 482957015634 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 482957015635 P-loop, Walker A motif; other site 482957015636 Base recognition motif; other site 482957015637 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 482957015638 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 482957015639 Flavoprotein; Region: Flavoprotein; pfam02441 482957015640 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 482957015641 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 482957015642 active site 482957015643 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 482957015644 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 482957015645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015646 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957015647 dimerization interface [polypeptide binding]; other site 482957015648 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957015651 dimerization interface [polypeptide binding]; other site 482957015652 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 482957015653 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 482957015654 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957015655 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957015656 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957015657 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 482957015658 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957015659 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 482957015660 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 482957015661 HAMP domain; Region: HAMP; pfam00672 482957015662 dimerization interface [polypeptide binding]; other site 482957015663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957015664 metal binding site [ion binding]; metal-binding site 482957015665 active site 482957015666 I-site; other site 482957015667 putative outer membrane lipoprotein; Provisional; Region: PRK09967 482957015668 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957015669 ligand binding site [chemical binding]; other site 482957015670 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 482957015671 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957015672 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957015673 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 482957015674 PAAR motif; Region: PAAR_motif; pfam05488 482957015675 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 482957015676 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 482957015677 RHS Repeat; Region: RHS_repeat; pfam05593 482957015678 RHS Repeat; Region: RHS_repeat; pfam05593 482957015679 RHS Repeat; Region: RHS_repeat; pfam05593 482957015680 RHS protein; Region: RHS; pfam03527 482957015681 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 482957015682 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957015683 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957015684 dimerization interface [polypeptide binding]; other site 482957015685 ligand binding site [chemical binding]; other site 482957015686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957015687 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957015688 TM-ABC transporter signature motif; other site 482957015689 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 482957015690 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 482957015691 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957015692 TM-ABC transporter signature motif; other site 482957015693 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 482957015694 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957015695 Walker A/P-loop; other site 482957015696 ATP binding site [chemical binding]; other site 482957015697 Q-loop/lid; other site 482957015698 ABC transporter signature motif; other site 482957015699 Walker B; other site 482957015700 D-loop; other site 482957015701 H-loop/switch region; other site 482957015702 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 482957015703 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957015704 Walker A/P-loop; other site 482957015705 ATP binding site [chemical binding]; other site 482957015706 Q-loop/lid; other site 482957015707 ABC transporter signature motif; other site 482957015708 Walker B; other site 482957015709 D-loop; other site 482957015710 H-loop/switch region; other site 482957015711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015713 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957015714 dimerization interface [polypeptide binding]; other site 482957015715 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 482957015716 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957015717 EamA-like transporter family; Region: EamA; pfam00892 482957015718 EamA-like transporter family; Region: EamA; pfam00892 482957015719 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957015720 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 482957015721 dimer interface [polypeptide binding]; other site 482957015722 Cupin; Region: Cupin_6; pfam12852 482957015723 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957015724 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015726 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957015727 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 482957015728 NADP binding site [chemical binding]; other site 482957015729 active site 482957015730 steroid binding site; other site 482957015731 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 482957015732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957015733 DNA binding residues [nucleotide binding] 482957015734 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957015735 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 482957015736 inhibitor-cofactor binding pocket; inhibition site 482957015737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957015738 catalytic residue [active] 482957015739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015741 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 482957015742 putative dimerization interface [polypeptide binding]; other site 482957015743 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 482957015744 chorismate binding enzyme; Region: Chorismate_bind; cl10555 482957015745 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 482957015746 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 482957015747 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 482957015748 nucleophilic elbow; other site 482957015749 catalytic triad; other site 482957015750 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 482957015751 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 482957015752 acyl-activating enzyme (AAE) consensus motif; other site 482957015753 active site 482957015754 AMP binding site [chemical binding]; other site 482957015755 substrate binding site [chemical binding]; other site 482957015756 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957015757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015758 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 482957015759 Condensation domain; Region: Condensation; pfam00668 482957015760 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 482957015761 Nonribosomal peptide synthase; Region: NRPS; pfam08415 482957015762 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 482957015763 acyl-activating enzyme (AAE) consensus motif; other site 482957015764 AMP binding site [chemical binding]; other site 482957015765 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957015766 Methyltransferase domain; Region: Methyltransf_12; pfam08242 482957015767 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957015768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 482957015769 Condensation domain; Region: Condensation; pfam00668 482957015770 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 482957015771 Nonribosomal peptide synthase; Region: NRPS; pfam08415 482957015772 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 482957015773 acyl-activating enzyme (AAE) consensus motif; other site 482957015774 AMP binding site [chemical binding]; other site 482957015775 Methyltransferase domain; Region: Methyltransf_12; pfam08242 482957015776 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957015777 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 482957015778 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 482957015779 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 482957015780 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 482957015781 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957015782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957015783 Walker A/P-loop; other site 482957015784 ATP binding site [chemical binding]; other site 482957015785 Q-loop/lid; other site 482957015786 ABC transporter signature motif; other site 482957015787 Walker B; other site 482957015788 D-loop; other site 482957015789 H-loop/switch region; other site 482957015790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957015791 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 482957015792 Walker A/P-loop; other site 482957015793 ATP binding site [chemical binding]; other site 482957015794 Q-loop/lid; other site 482957015795 ABC transporter signature motif; other site 482957015796 Walker B; other site 482957015797 D-loop; other site 482957015798 H-loop/switch region; other site 482957015799 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 482957015800 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957015801 N-terminal plug; other site 482957015802 ligand-binding site [chemical binding]; other site 482957015803 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 482957015804 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 482957015805 muropeptide transporter; Validated; Region: ampG; cl17669 482957015806 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957015807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015808 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957015809 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957015810 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957015811 Uncharacterized conserved protein [Function unknown]; Region: COG5476 482957015812 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 482957015813 MlrC C-terminus; Region: MlrC_C; pfam07171 482957015814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015815 putative substrate translocation pore; other site 482957015816 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957015817 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 482957015818 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957015819 N-terminal plug; other site 482957015820 ligand-binding site [chemical binding]; other site 482957015821 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 482957015822 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 482957015823 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 482957015824 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957015825 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957015826 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957015827 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957015828 Leucine rich repeat; Region: LRR_8; pfam13855 482957015829 Protein kinase domain; Region: Pkinase; pfam00069 482957015830 Catalytic domain of Protein Kinases; Region: PKc; cd00180 482957015831 active site 482957015832 ATP binding site [chemical binding]; other site 482957015833 substrate binding site [chemical binding]; other site 482957015834 activation loop (A-loop); other site 482957015835 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957015836 Protein of unknown function (DUF461); Region: DUF461; pfam04314 482957015837 CopC domain; Region: CopC; pfam04234 482957015838 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 482957015839 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 482957015840 putative hydrophobic ligand binding site [chemical binding]; other site 482957015841 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957015842 catalytic loop [active] 482957015843 iron binding site [ion binding]; other site 482957015844 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 482957015845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957015846 Walker A motif; other site 482957015847 ATP binding site [chemical binding]; other site 482957015848 Walker B motif; other site 482957015849 arginine finger; other site 482957015850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957015851 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 482957015852 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 482957015853 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 482957015854 TPR repeat; Region: TPR_11; pfam13414 482957015855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957015856 binding surface 482957015857 TPR motif; other site 482957015858 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 482957015859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957015860 binding surface 482957015861 TPR motif; other site 482957015862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957015863 TPR motif; other site 482957015864 binding surface 482957015865 TPR repeat; Region: TPR_11; pfam13414 482957015866 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 482957015867 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 482957015868 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 482957015869 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 482957015870 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 482957015871 short chain dehydrogenase; Validated; Region: PRK05855 482957015872 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957015873 classical (c) SDRs; Region: SDR_c; cd05233 482957015874 NAD(P) binding site [chemical binding]; other site 482957015875 active site 482957015876 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 482957015877 active site 482957015878 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 482957015879 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 482957015880 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 482957015881 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 482957015882 active site residues [active] 482957015883 dimer interface [polypeptide binding]; other site 482957015884 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 482957015885 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957015886 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957015887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957015888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957015889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957015890 active site 482957015891 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 482957015892 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 482957015893 active site 482957015894 acyl-activating enzyme (AAE) consensus motif; other site 482957015895 putative CoA binding site [chemical binding]; other site 482957015896 AMP binding site [chemical binding]; other site 482957015897 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 482957015898 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 482957015899 tetrameric interface [polypeptide binding]; other site 482957015900 NAD binding site [chemical binding]; other site 482957015901 catalytic residues [active] 482957015902 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957015903 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 482957015904 enoyl-CoA hydratase; Provisional; Region: PRK09076 482957015905 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957015906 substrate binding site [chemical binding]; other site 482957015907 oxyanion hole (OAH) forming residues; other site 482957015908 trimer interface [polypeptide binding]; other site 482957015909 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 482957015910 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957015911 substrate binding site [chemical binding]; other site 482957015912 oxyanion hole (OAH) forming residues; other site 482957015913 trimer interface [polypeptide binding]; other site 482957015914 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 482957015915 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 482957015916 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 482957015917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957015918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957015919 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 482957015920 putative effector binding pocket; other site 482957015921 putative dimerization interface [polypeptide binding]; other site 482957015922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957015923 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957015924 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957015925 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 482957015926 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 482957015927 Walker A/P-loop; other site 482957015928 ATP binding site [chemical binding]; other site 482957015929 Q-loop/lid; other site 482957015930 ABC transporter signature motif; other site 482957015931 Walker B; other site 482957015932 D-loop; other site 482957015933 H-loop/switch region; other site 482957015934 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 482957015935 FtsX-like permease family; Region: FtsX; pfam02687 482957015936 macrolide transporter subunit MacA; Provisional; Region: PRK11578 482957015937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957015938 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957015939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957015940 S-adenosylmethionine binding site [chemical binding]; other site 482957015941 HD domain; Region: HD_3; pfam13023 482957015942 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957015943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957015944 non-specific DNA binding site [nucleotide binding]; other site 482957015945 salt bridge; other site 482957015946 sequence-specific DNA binding site [nucleotide binding]; other site 482957015947 acid-resistance membrane protein; Provisional; Region: PRK10209 482957015948 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 482957015949 B1 nucleotide binding pocket [chemical binding]; other site 482957015950 B2 nucleotide binding pocket [chemical binding]; other site 482957015951 CAS motifs; other site 482957015952 active site 482957015953 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 482957015954 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957015955 putative di-iron ligands [ion binding]; other site 482957015956 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 482957015957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957015958 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 482957015959 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 482957015960 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957015961 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 482957015962 putative di-iron ligands [ion binding]; other site 482957015963 GH3 auxin-responsive promoter; Region: GH3; pfam03321 482957015964 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957015965 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957015966 [2Fe-2S] cluster binding site [ion binding]; other site 482957015967 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 482957015968 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957015969 putative di-iron ligands [ion binding]; other site 482957015970 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 482957015971 hypothetical protein; Provisional; Region: PRK06834 482957015972 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957015973 hypothetical protein; Provisional; Region: PRK07236 482957015974 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 482957015975 Isochorismatase family; Region: Isochorismatase; pfam00857 482957015976 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 482957015977 catalytic triad [active] 482957015978 conserved cis-peptide bond; other site 482957015979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957015980 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 482957015981 dimer interface [polypeptide binding]; other site 482957015982 putative metal binding site [ion binding]; other site 482957015983 Cytochrome c; Region: Cytochrom_C; cl11414 482957015984 Cytochrome c; Region: Cytochrom_C; pfam00034 482957015985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957015986 Coenzyme A binding pocket [chemical binding]; other site 482957015987 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 482957015988 glutaminase; Provisional; Region: PRK00971 482957015989 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 482957015990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957015991 active site 482957015992 phosphorylation site [posttranslational modification] 482957015993 intermolecular recognition site; other site 482957015994 dimerization interface [polypeptide binding]; other site 482957015995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957015996 DNA binding site [nucleotide binding] 482957015997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957015998 dimer interface [polypeptide binding]; other site 482957015999 phosphorylation site [posttranslational modification] 482957016000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957016001 ATP binding site [chemical binding]; other site 482957016002 Mg2+ binding site [ion binding]; other site 482957016003 G-X-G motif; other site 482957016004 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 482957016005 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957016006 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 482957016007 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 482957016008 active site 482957016009 nucleophile elbow; other site 482957016010 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 482957016011 Surface antigen; Region: Bac_surface_Ag; pfam01103 482957016012 rod shape-determining protein MreB; Provisional; Region: PRK13930 482957016013 MreB and similar proteins; Region: MreB_like; cd10225 482957016014 nucleotide binding site [chemical binding]; other site 482957016015 Mg binding site [ion binding]; other site 482957016016 putative protofilament interaction site [polypeptide binding]; other site 482957016017 RodZ interaction site [polypeptide binding]; other site 482957016018 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 482957016019 putative active site [active] 482957016020 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 482957016021 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 482957016022 Autotransporter beta-domain; Region: Autotransporter; pfam03797 482957016023 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 482957016024 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 482957016025 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957016026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016027 The C-terminal substrate-binding domain of LysR-type trnascriptional regulator BlaA which involved in control of the beta-lactamase gene expression; contains the type 2 periplasmic binding fold; Region: PBP2_BlaA; cd08487 482957016028 putative dimerization interface [polypeptide binding]; other site 482957016029 putative substrate binding pocket [chemical binding]; other site 482957016030 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 482957016031 Protein of unknown function (DUF805); Region: DUF805; pfam05656 482957016032 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 482957016033 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957016034 MarR family; Region: MarR_2; pfam12802 482957016035 sensor protein QseC; Provisional; Region: PRK10337 482957016036 HAMP domain; Region: HAMP; pfam00672 482957016037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957016038 dimer interface [polypeptide binding]; other site 482957016039 phosphorylation site [posttranslational modification] 482957016040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957016041 ATP binding site [chemical binding]; other site 482957016042 Mg2+ binding site [ion binding]; other site 482957016043 G-X-G motif; other site 482957016044 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 482957016045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957016046 active site 482957016047 phosphorylation site [posttranslational modification] 482957016048 intermolecular recognition site; other site 482957016049 dimerization interface [polypeptide binding]; other site 482957016050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957016051 DNA binding site [nucleotide binding] 482957016052 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 482957016053 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 482957016054 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957016055 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 482957016056 putative active site [active] 482957016057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957016058 Coenzyme A binding pocket [chemical binding]; other site 482957016059 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 482957016060 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957016061 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 482957016062 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 482957016063 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 482957016064 tetramer interface [polypeptide binding]; other site 482957016065 active site 482957016066 Mg2+/Mn2+ binding site [ion binding]; other site 482957016067 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 482957016068 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 482957016069 Cytochrome P450; Region: p450; cl12078 482957016070 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 482957016071 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 482957016072 active site residue [active] 482957016073 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 482957016074 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957016075 conserved cys residue [active] 482957016076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957016077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957016078 arginine decarboxylase; Provisional; Region: PRK15029 482957016079 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 482957016080 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957016081 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957016082 catalytic residue [active] 482957016083 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 482957016084 arginine:agmatin antiporter; Provisional; Region: PRK10644 482957016085 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 482957016086 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957016087 FMN binding site [chemical binding]; other site 482957016088 substrate binding site [chemical binding]; other site 482957016089 putative catalytic residue [active] 482957016090 hypothetical protein; Provisional; Region: PRK07907 482957016091 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 482957016092 metal binding site [ion binding]; metal-binding site 482957016093 putative dimer interface [polypeptide binding]; other site 482957016094 putative dehydrogenase; Provisional; Region: PRK10098 482957016095 TfoX N-terminal domain; Region: TfoX_N; pfam04993 482957016096 NnrU protein; Region: NnrU; pfam07298 482957016097 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 482957016098 Spore germination protein; Region: Spore_permease; cl17796 482957016099 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957016100 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 482957016101 iron-sulfur cluster [ion binding]; other site 482957016102 [2Fe-2S] cluster binding site [ion binding]; other site 482957016103 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 482957016104 hydrophobic ligand binding site; other site 482957016105 Rubredoxin [Energy production and conversion]; Region: COG1773 482957016106 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 482957016107 iron binding site [ion binding]; other site 482957016108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 482957016109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957016110 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957016111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016113 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 482957016114 putative substrate binding pocket [chemical binding]; other site 482957016115 putative dimerization interface [polypeptide binding]; other site 482957016116 hypothetical protein; Provisional; Region: PRK10621 482957016117 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 482957016118 Right handed beta helix region; Region: Beta_helix; pfam13229 482957016119 Protein of unknown function, DUF488; Region: DUF488; pfam04343 482957016120 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 482957016121 hypothetical protein; Provisional; Region: PRK07236 482957016122 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 482957016123 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 482957016124 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 482957016125 catalytic residues [active] 482957016126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016128 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957016129 putative effector binding pocket; other site 482957016130 dimerization interface [polypeptide binding]; other site 482957016131 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 482957016132 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 482957016133 cytosine deaminase; Provisional; Region: PRK09230 482957016134 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 482957016135 active site 482957016136 cytosine permease; Provisional; Region: codB; PRK11017 482957016137 Na binding site [ion binding]; other site 482957016138 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957016139 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957016140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957016141 non-specific DNA binding site [nucleotide binding]; other site 482957016142 salt bridge; other site 482957016143 sequence-specific DNA binding site [nucleotide binding]; other site 482957016144 Cupin domain; Region: Cupin_2; pfam07883 482957016145 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 482957016146 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 482957016147 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 482957016148 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957016149 catalytic loop [active] 482957016150 iron binding site [ion binding]; other site 482957016151 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957016152 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957016153 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957016154 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 482957016155 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957016156 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957016157 Cytochrome c; Region: Cytochrom_C; pfam00034 482957016158 hypothetical protein; Provisional; Region: PRK07236 482957016159 hypothetical protein; Provisional; Region: PRK06753 482957016160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016162 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957016163 putative effector binding pocket; other site 482957016164 dimerization interface [polypeptide binding]; other site 482957016165 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957016166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957016167 Coenzyme A binding pocket [chemical binding]; other site 482957016168 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 482957016169 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 482957016170 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 482957016171 active site 482957016172 metal binding site [ion binding]; metal-binding site 482957016173 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 482957016174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957016175 spermidine synthase; Provisional; Region: PRK03612 482957016176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957016177 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 482957016178 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 482957016179 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 482957016180 Short C-terminal domain; Region: SHOCT; pfam09851 482957016181 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 482957016182 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 482957016183 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 482957016184 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 482957016185 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 482957016186 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 482957016187 hydrophobic ligand binding site; other site 482957016188 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 482957016189 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 482957016190 active site 482957016191 nucleotide binding site [chemical binding]; other site 482957016192 HIGH motif; other site 482957016193 KMSKS motif; other site 482957016194 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 482957016195 nudix motif; other site 482957016196 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 482957016197 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 482957016198 active site 482957016199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957016200 Coenzyme A binding pocket [chemical binding]; other site 482957016201 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957016202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957016203 DNA-binding site [nucleotide binding]; DNA binding site 482957016204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957016205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957016206 homodimer interface [polypeptide binding]; other site 482957016207 catalytic residue [active] 482957016208 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957016209 EamA-like transporter family; Region: EamA; pfam00892 482957016210 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 482957016211 putative dimer interface [polypeptide binding]; other site 482957016212 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957016213 Predicted transcriptional regulator [Transcription]; Region: COG2378 482957016214 HTH domain; Region: HTH_11; pfam08279 482957016215 WYL domain; Region: WYL; pfam13280 482957016216 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 482957016217 cystathionine beta-lyase; Provisional; Region: PRK09028 482957016218 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 482957016219 homodimer interface [polypeptide binding]; other site 482957016220 substrate-cofactor binding pocket; other site 482957016221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957016222 catalytic residue [active] 482957016223 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 482957016224 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957016225 Walker A/P-loop; other site 482957016226 ATP binding site [chemical binding]; other site 482957016227 Q-loop/lid; other site 482957016228 ABC transporter signature motif; other site 482957016229 Walker B; other site 482957016230 D-loop; other site 482957016231 H-loop/switch region; other site 482957016232 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957016233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957016234 dimer interface [polypeptide binding]; other site 482957016235 conserved gate region; other site 482957016236 putative PBP binding loops; other site 482957016237 ABC-ATPase subunit interface; other site 482957016238 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957016239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957016240 substrate binding pocket [chemical binding]; other site 482957016241 membrane-bound complex binding site; other site 482957016242 hinge residues; other site 482957016243 diaminopimelate decarboxylase; Provisional; Region: PRK11165 482957016244 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 482957016245 active site 482957016246 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957016247 substrate binding site [chemical binding]; other site 482957016248 catalytic residues [active] 482957016249 dimer interface [polypeptide binding]; other site 482957016250 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 482957016251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957016253 dimerization interface [polypeptide binding]; other site 482957016254 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 482957016255 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957016256 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 482957016257 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 482957016258 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 482957016259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957016260 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 482957016261 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 482957016262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957016263 Coenzyme A binding pocket [chemical binding]; other site 482957016264 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 482957016265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 482957016266 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 482957016267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957016269 putative substrate translocation pore; other site 482957016270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957016271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957016272 Trehalase; Region: Trehalase; cl17346 482957016273 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 482957016274 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 482957016275 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 482957016276 Autoinducer binding domain; Region: Autoind_bind; pfam03472 482957016277 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957016278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957016279 DNA binding residues [nucleotide binding] 482957016280 dimerization interface [polypeptide binding]; other site 482957016281 Autoinducer binding domain; Region: Autoind_bind; pfam03472 482957016282 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 482957016283 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 482957016284 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 482957016285 active site 482957016286 dimer interface [polypeptide binding]; other site 482957016287 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 482957016288 Ligand Binding Site [chemical binding]; other site 482957016289 Molecular Tunnel; other site 482957016290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957016291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957016292 DNA binding site [nucleotide binding] 482957016293 Fic family protein [Function unknown]; Region: COG3177 482957016294 Fic/DOC family; Region: Fic; pfam02661 482957016295 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957016296 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957016297 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 482957016298 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957016299 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 482957016300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957016301 catalytic loop [active] 482957016302 iron binding site [ion binding]; other site 482957016303 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957016304 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 482957016305 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957016306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957016307 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 482957016308 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 482957016309 DXD motif; other site 482957016310 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 482957016311 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 482957016312 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 482957016313 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 482957016314 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 482957016315 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 482957016316 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 482957016317 NAD binding site [chemical binding]; other site 482957016318 homodimer interface [polypeptide binding]; other site 482957016319 active site 482957016320 substrate binding site [chemical binding]; other site 482957016321 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 482957016322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957016323 NAD binding site [chemical binding]; other site 482957016324 putative substrate binding site 2 [chemical binding]; other site 482957016325 putative substrate binding site 1 [chemical binding]; other site 482957016326 active site 482957016327 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 482957016328 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957016329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957016330 Walker A motif; other site 482957016331 ATP binding site [chemical binding]; other site 482957016332 Walker B motif; other site 482957016333 arginine finger; other site 482957016334 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 482957016335 DNA-binding interface [nucleotide binding]; DNA binding site 482957016336 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957016337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957016338 DNA binding residues [nucleotide binding] 482957016339 dimerization interface [polypeptide binding]; other site 482957016340 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 482957016341 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 482957016342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957016343 dimer interface [polypeptide binding]; other site 482957016344 putative CheW interface [polypeptide binding]; other site 482957016345 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 482957016346 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 482957016347 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 482957016348 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957016349 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957016350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957016351 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 482957016352 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 482957016353 putative ligand binding site [chemical binding]; other site 482957016354 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 482957016355 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957016356 Walker A/P-loop; other site 482957016357 ATP binding site [chemical binding]; other site 482957016358 Q-loop/lid; other site 482957016359 ABC transporter signature motif; other site 482957016360 Walker B; other site 482957016361 D-loop; other site 482957016362 H-loop/switch region; other site 482957016363 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957016364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957016365 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957016366 TM-ABC transporter signature motif; other site 482957016367 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 482957016368 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 482957016369 putative NAD(P) binding site [chemical binding]; other site 482957016370 catalytic Zn binding site [ion binding]; other site 482957016371 structural Zn binding site [ion binding]; other site 482957016372 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 482957016373 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 482957016374 N- and C-terminal domain interface [polypeptide binding]; other site 482957016375 putative active site [active] 482957016376 MgATP binding site [chemical binding]; other site 482957016377 catalytic site [active] 482957016378 metal binding site [ion binding]; metal-binding site 482957016379 putative xylulose binding site [chemical binding]; other site 482957016380 putative homodimer interface [polypeptide binding]; other site 482957016381 short chain dehydrogenase; Provisional; Region: PRK07060 482957016382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957016383 NAD(P) binding site [chemical binding]; other site 482957016384 active site 482957016385 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 482957016386 metal-binding site 482957016387 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 482957016388 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 482957016389 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957016390 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 482957016391 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957016392 N-terminal plug; other site 482957016393 ligand-binding site [chemical binding]; other site 482957016394 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 482957016395 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 482957016396 oligomeric interface; other site 482957016397 putative active site [active] 482957016398 homodimer interface [polypeptide binding]; other site 482957016399 aspartate carbamoyltransferase; Provisional; Region: PRK11891 482957016400 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 482957016401 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 482957016402 Entericidin EcnA/B family; Region: Entericidin; pfam08085 482957016403 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957016404 EamA-like transporter family; Region: EamA; pfam00892 482957016405 EamA-like transporter family; Region: EamA; pfam00892 482957016406 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957016407 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957016408 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 482957016409 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 482957016410 classical (c) SDRs; Region: SDR_c; cd05233 482957016411 NAD(P) binding site [chemical binding]; other site 482957016412 active site 482957016413 Cupin domain; Region: Cupin_2; cl17218 482957016414 dihydrodipicolinate reductase; Region: dapB_plant; TIGR02130 482957016415 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 482957016416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957016417 dimerization interface [polypeptide binding]; other site 482957016418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957016419 dimer interface [polypeptide binding]; other site 482957016420 phosphorylation site [posttranslational modification] 482957016421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957016422 ATP binding site [chemical binding]; other site 482957016423 Mg2+ binding site [ion binding]; other site 482957016424 G-X-G motif; other site 482957016425 osmolarity response regulator; Provisional; Region: ompR; PRK09468 482957016426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957016427 active site 482957016428 phosphorylation site [posttranslational modification] 482957016429 intermolecular recognition site; other site 482957016430 dimerization interface [polypeptide binding]; other site 482957016431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957016432 DNA binding site [nucleotide binding] 482957016433 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 482957016434 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 482957016435 short chain dehydrogenase; Provisional; Region: PRK12828 482957016436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957016437 NAD(P) binding site [chemical binding]; other site 482957016438 active site 482957016439 DNA-binding response regulator CreB; Provisional; Region: PRK11083 482957016440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957016441 active site 482957016442 phosphorylation site [posttranslational modification] 482957016443 intermolecular recognition site; other site 482957016444 dimerization interface [polypeptide binding]; other site 482957016445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957016446 DNA binding site [nucleotide binding] 482957016447 sensory histidine kinase CreC; Provisional; Region: PRK11100 482957016448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957016449 dimerization interface [polypeptide binding]; other site 482957016450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957016451 dimer interface [polypeptide binding]; other site 482957016452 phosphorylation site [posttranslational modification] 482957016453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957016454 ATP binding site [chemical binding]; other site 482957016455 Mg2+ binding site [ion binding]; other site 482957016456 G-X-G motif; other site 482957016457 inner membrane protein; Provisional; Region: PRK11715 482957016458 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957016459 homotrimer interaction site [polypeptide binding]; other site 482957016460 putative active site [active] 482957016461 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 482957016462 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 482957016463 active site 482957016464 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 482957016465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016466 putative substrate translocation pore; other site 482957016467 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016468 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957016470 dimerization interface [polypeptide binding]; other site 482957016471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016473 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957016474 putative effector binding pocket; other site 482957016475 dimerization interface [polypeptide binding]; other site 482957016476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957016477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957016478 NAD(P) binding site [chemical binding]; other site 482957016479 active site 482957016480 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 482957016481 hypothetical protein; Reviewed; Region: PRK09588 482957016482 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 482957016483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016484 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957016485 putative substrate translocation pore; other site 482957016486 carbamoyl-phosphate synthase; Region: PLN02735 482957016487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957016490 dimerization interface [polypeptide binding]; other site 482957016491 classical (c) SDRs; Region: SDR_c; cd05233 482957016492 short chain dehydrogenase; Provisional; Region: PRK07478 482957016493 NAD(P) binding site [chemical binding]; other site 482957016494 active site 482957016495 Predicted metalloprotease [General function prediction only]; Region: COG2321 482957016496 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 482957016497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957016498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957016499 DNA binding residues [nucleotide binding] 482957016500 dimerization interface [polypeptide binding]; other site 482957016501 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957016502 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957016503 NAD(P) binding site [chemical binding]; other site 482957016504 catalytic residues [active] 482957016505 hypothetical protein; Provisional; Region: PRK07481 482957016506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957016507 inhibitor-cofactor binding pocket; inhibition site 482957016508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957016509 catalytic residue [active] 482957016510 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 482957016511 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 482957016512 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957016513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957016514 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957016515 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957016516 trimer interface [polypeptide binding]; other site 482957016517 eyelet of channel; other site 482957016518 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 482957016519 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957016520 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 482957016521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957016522 dimer interface [polypeptide binding]; other site 482957016523 conserved gate region; other site 482957016524 putative PBP binding loops; other site 482957016525 ABC-ATPase subunit interface; other site 482957016526 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 482957016527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957016528 dimer interface [polypeptide binding]; other site 482957016529 conserved gate region; other site 482957016530 putative PBP binding loops; other site 482957016531 ABC-ATPase subunit interface; other site 482957016532 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957016533 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957016534 DNA binding site [nucleotide binding] 482957016535 domain linker motif; other site 482957016536 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 482957016537 putative dimerization interface [polypeptide binding]; other site 482957016538 putative ligand binding site [chemical binding]; other site 482957016539 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 482957016540 active site 482957016541 catalytic site [active] 482957016542 putative metal binding site [ion binding]; other site 482957016543 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957016544 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 482957016545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957016546 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957016547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957016548 Coenzyme A binding pocket [chemical binding]; other site 482957016549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957016552 dimerization interface [polypeptide binding]; other site 482957016553 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957016554 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957016555 metal binding site [ion binding]; metal-binding site 482957016556 putative dimer interface [polypeptide binding]; other site 482957016557 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957016558 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957016559 trimer interface [polypeptide binding]; other site 482957016560 eyelet of channel; other site 482957016561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016562 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957016563 putative substrate translocation pore; other site 482957016564 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957016565 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 482957016566 FMN binding site [chemical binding]; other site 482957016567 active site 482957016568 substrate binding site [chemical binding]; other site 482957016569 catalytic residue [active] 482957016570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957016571 dimerization interface [polypeptide binding]; other site 482957016572 putative DNA binding site [nucleotide binding]; other site 482957016573 putative Zn2+ binding site [ion binding]; other site 482957016574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957016575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957016576 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 482957016577 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957016578 substrate binding pocket [chemical binding]; other site 482957016579 catalytic triad [active] 482957016580 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 482957016581 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 482957016582 classical (c) SDRs; Region: SDR_c; cd05233 482957016583 NAD(P) binding site [chemical binding]; other site 482957016584 active site 482957016585 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957016586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957016587 dimerization interface [polypeptide binding]; other site 482957016588 putative DNA binding site [nucleotide binding]; other site 482957016589 putative Zn2+ binding site [ion binding]; other site 482957016590 Uncharacterized conserved protein [Function unknown]; Region: COG2128 482957016591 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957016592 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957016593 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957016594 dimerization interface [polypeptide binding]; other site 482957016595 putative DNA binding site [nucleotide binding]; other site 482957016596 putative Zn2+ binding site [ion binding]; other site 482957016597 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 482957016598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957016599 motif II; other site 482957016600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016601 D-galactonate transporter; Region: 2A0114; TIGR00893 482957016602 putative substrate translocation pore; other site 482957016603 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 482957016604 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 482957016605 dimerization interface [polypeptide binding]; other site 482957016606 NAD binding site [chemical binding]; other site 482957016607 ligand binding site [chemical binding]; other site 482957016608 catalytic site [active] 482957016609 Ssu72-like protein; Region: Ssu72; cl02161 482957016610 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 482957016611 nucleophile elbow; other site 482957016612 Patatin phospholipase; Region: DUF3734; pfam12536 482957016613 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 482957016614 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 482957016615 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 482957016616 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 482957016617 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 482957016618 active site 482957016619 metal binding site [ion binding]; metal-binding site 482957016620 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 482957016621 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 482957016622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957016623 dimer interface [polypeptide binding]; other site 482957016624 conserved gate region; other site 482957016625 putative PBP binding loops; other site 482957016626 ABC-ATPase subunit interface; other site 482957016627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957016628 putative PBP binding loops; other site 482957016629 dimer interface [polypeptide binding]; other site 482957016630 ABC-ATPase subunit interface; other site 482957016631 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 482957016632 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957016633 Walker A/P-loop; other site 482957016634 ATP binding site [chemical binding]; other site 482957016635 Q-loop/lid; other site 482957016636 ABC transporter signature motif; other site 482957016637 Walker B; other site 482957016638 D-loop; other site 482957016639 H-loop/switch region; other site 482957016640 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 482957016641 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 482957016642 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 482957016643 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 482957016644 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 482957016645 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 482957016646 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 482957016647 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 482957016648 ImpE protein; Region: ImpE; pfam07024 482957016649 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 482957016650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957016651 Walker A motif; other site 482957016652 ATP binding site [chemical binding]; other site 482957016653 Walker B motif; other site 482957016654 arginine finger; other site 482957016655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957016656 Walker A motif; other site 482957016657 ATP binding site [chemical binding]; other site 482957016658 Walker B motif; other site 482957016659 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 482957016660 Protein of unknown function (DUF770); Region: DUF770; pfam05591 482957016661 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 482957016662 Protein of unknown function (DUF877); Region: DUF877; pfam05943 482957016663 Protein of unknown function (DUF796); Region: DUF796; pfam05638 482957016664 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 482957016665 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 482957016666 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 482957016667 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 482957016668 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957016669 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957016670 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957016671 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957016672 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 482957016673 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 482957016674 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 482957016675 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 482957016676 PAAR motif; Region: PAAR_motif; pfam05488 482957016677 hypothetical protein; Provisional; Region: PRK08126 482957016678 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 482957016679 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957016680 ligand binding site [chemical binding]; other site 482957016681 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 482957016682 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 482957016683 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 482957016684 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 482957016685 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957016686 ligand binding site [chemical binding]; other site 482957016687 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 482957016688 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957016689 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 482957016690 putative active site [active] 482957016691 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 482957016692 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 482957016693 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 482957016694 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 482957016695 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 482957016696 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 482957016697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957016698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957016699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957016700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957016701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016703 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957016704 dimerization interface [polypeptide binding]; other site 482957016705 substrate binding pocket [chemical binding]; other site 482957016706 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957016707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957016708 NAD(P) binding site [chemical binding]; other site 482957016709 active site 482957016710 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 482957016711 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 482957016712 DNA binding residues [nucleotide binding] 482957016713 dimer interface [polypeptide binding]; other site 482957016714 [2Fe-2S] cluster binding site [ion binding]; other site 482957016715 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 482957016716 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957016717 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957016718 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 482957016719 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957016720 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 482957016721 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 482957016722 dimer interface [polypeptide binding]; other site 482957016723 TPP-binding site [chemical binding]; other site 482957016724 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 482957016725 MarR family; Region: MarR_2; pfam12802 482957016726 DNA gyrase, B subunit; Region: gyrB; TIGR01059 482957016727 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 482957016728 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 482957016729 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 482957016730 C-terminal domain interface [polypeptide binding]; other site 482957016731 GSH binding site (G-site) [chemical binding]; other site 482957016732 dimer interface [polypeptide binding]; other site 482957016733 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 482957016734 dimer interface [polypeptide binding]; other site 482957016735 N-terminal domain interface [polypeptide binding]; other site 482957016736 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 482957016737 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957016738 Na binding site [ion binding]; other site 482957016739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957016740 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957016741 NAD(P) binding site [chemical binding]; other site 482957016742 active site 482957016743 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 482957016744 dimer interface [polypeptide binding]; other site 482957016745 substrate binding site [chemical binding]; other site 482957016746 metal binding site [ion binding]; metal-binding site 482957016747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957016748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957016749 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 482957016750 putative dimerization interface [polypeptide binding]; other site 482957016751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016752 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957016753 putative substrate translocation pore; other site 482957016754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957016756 putative substrate translocation pore; other site 482957016757 Isochorismatase family; Region: Isochorismatase; pfam00857 482957016758 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 482957016759 catalytic triad [active] 482957016760 conserved cis-peptide bond; other site 482957016761 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 482957016762 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 482957016763 active site 482957016764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957016765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957016766 DNA binding residues [nucleotide binding] 482957016767 dimerization interface [polypeptide binding]; other site 482957016768 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 482957016769 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957016770 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 482957016771 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957016772 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957016773 trimer interface [polypeptide binding]; other site 482957016774 eyelet of channel; other site 482957016775 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 482957016776 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 482957016777 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957016778 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 482957016779 FOG: CBS domain [General function prediction only]; Region: COG0517 482957016780 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 482957016781 dimerization interface [polypeptide binding]; other site 482957016782 active site 482957016783 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957016784 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 482957016785 active site 482957016786 DNA binding site [nucleotide binding] 482957016787 Int/Topo IB signature motif; other site 482957016788 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 482957016789 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 482957016790 gpW; Region: gpW; pfam02831 482957016791 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 482957016792 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957016793 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957016794 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957016795 catalytic residue [active] 482957016796 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 482957016797 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 482957016798 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957016799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957016800 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 482957016801 active site 482957016802 metal binding site [ion binding]; metal-binding site 482957016803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957016804 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 482957016805 Autoinducer synthetase; Region: Autoind_synth; cl17404 482957016806 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 482957016807 Autoinducer binding domain; Region: Autoind_bind; pfam03472 482957016808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957016809 DNA binding residues [nucleotide binding] 482957016810 dimerization interface [polypeptide binding]; other site 482957016811 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 482957016812 MgtC family; Region: MgtC; pfam02308 482957016813 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 482957016814 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 482957016815 multidrug resistance protein MdtN; Provisional; Region: PRK10476 482957016816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957016817 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957016818 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 482957016819 putative active site [active] 482957016820 putative metal binding site [ion binding]; other site 482957016821 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 482957016822 putative FMN binding site [chemical binding]; other site 482957016823 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 482957016824 type II secretion system protein I; Region: gspI; TIGR01707 482957016825 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 482957016826 TPR repeat; Region: TPR_11; pfam13414 482957016827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016828 binding surface 482957016829 TPR motif; other site 482957016830 TPR repeat; Region: TPR_11; pfam13414 482957016831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016832 binding surface 482957016833 TPR motif; other site 482957016834 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 482957016835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016836 binding surface 482957016837 TPR motif; other site 482957016838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016839 TPR motif; other site 482957016840 binding surface 482957016841 TPR repeat; Region: TPR_11; pfam13414 482957016842 TPR repeat; Region: TPR_11; pfam13414 482957016843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016844 binding surface 482957016845 TPR motif; other site 482957016846 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 482957016847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016848 binding surface 482957016849 TPR motif; other site 482957016850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016851 binding surface 482957016852 TPR motif; other site 482957016853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016854 binding surface 482957016855 TPR motif; other site 482957016856 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957016857 TPR repeat; Region: TPR_11; pfam13414 482957016858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016859 binding surface 482957016860 TPR motif; other site 482957016861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016862 binding surface 482957016863 TPR motif; other site 482957016864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957016865 binding surface 482957016866 TPR motif; other site 482957016867 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957016868 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 482957016869 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 482957016870 PBP superfamily domain; Region: PBP_like_2; cl17296 482957016871 PBP superfamily domain; Region: PBP_like_2; cl17296 482957016872 type II secretion system protein F; Region: GspF; TIGR02120 482957016873 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957016874 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957016875 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 482957016876 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 482957016877 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 482957016878 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 482957016879 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 482957016880 Secretin and TonB N terminus short domain; Region: STN; pfam07660 482957016881 TonB C terminal; Region: TonB_2; pfam13103 482957016882 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 482957016883 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 482957016884 FecR protein; Region: FecR; pfam04773 482957016885 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 482957016886 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 482957016887 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 482957016888 TIGR03032 family protein; Region: TIGR03032 482957016889 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 482957016890 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 482957016891 ligand-binding site [chemical binding]; other site 482957016892 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 482957016893 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 482957016894 Surface antigen; Region: Bac_surface_Ag; pfam01103 482957016895 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 482957016896 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 482957016897 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 482957016898 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957016899 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 482957016900 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 482957016901 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 482957016902 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 482957016903 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 482957016904 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957016905 protein binding site [polypeptide binding]; other site 482957016906 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957016907 protein binding site [polypeptide binding]; other site 482957016908 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957016909 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957016910 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957016911 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957016912 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957016913 trimer interface [polypeptide binding]; other site 482957016914 eyelet of channel; other site 482957016915 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 482957016916 [2Fe-2S] cluster binding site [ion binding]; other site 482957016917 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957016918 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957016919 [2Fe-2S] cluster binding site [ion binding]; other site 482957016920 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 482957016921 hydrophobic ligand binding site; other site 482957016922 short chain dehydrogenase; Provisional; Region: PRK12939 482957016923 classical (c) SDRs; Region: SDR_c; cd05233 482957016924 NAD(P) binding site [chemical binding]; other site 482957016925 active site 482957016926 Cupin domain; Region: Cupin_2; pfam07883 482957016927 Serine hydrolase; Region: Ser_hydrolase; cl17834 482957016928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957016929 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957016930 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957016931 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957016932 short chain dehydrogenase; Provisional; Region: PRK07062 482957016933 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 482957016934 putative NAD(P) binding site [chemical binding]; other site 482957016935 putative active site [active] 482957016936 hypothetical protein; Provisional; Region: PRK07064 482957016937 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957016938 PYR/PP interface [polypeptide binding]; other site 482957016939 dimer interface [polypeptide binding]; other site 482957016940 TPP binding site [chemical binding]; other site 482957016941 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957016942 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 482957016943 TPP-binding site [chemical binding]; other site 482957016944 L-aspartate dehydrogenase; Provisional; Region: PRK13303 482957016945 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 482957016946 Domain of unknown function DUF108; Region: DUF108; pfam01958 482957016947 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957016948 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 482957016949 NAD(P) binding site [chemical binding]; other site 482957016950 catalytic residues [active] 482957016951 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 482957016952 active site 482957016953 metal binding site [ion binding]; metal-binding site 482957016954 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 482957016955 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 482957016956 putative active site [active] 482957016957 putative metal binding site [ion binding]; other site 482957016958 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 482957016959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957016960 benzoate transport; Region: 2A0115; TIGR00895 482957016961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016962 putative substrate translocation pore; other site 482957016963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957016964 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957016965 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957016966 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957016967 homotrimer interaction site [polypeptide binding]; other site 482957016968 putative active site [active] 482957016969 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 482957016970 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 482957016971 hybrid cluster protein; Provisional; Region: PRK05290 482957016972 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 482957016973 ACS interaction site; other site 482957016974 CODH interaction site; other site 482957016975 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 482957016976 hybrid metal cluster; other site 482957016977 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 482957016978 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957016979 catalytic loop [active] 482957016980 iron binding site [ion binding]; other site 482957016981 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 482957016982 FAD binding pocket [chemical binding]; other site 482957016983 conserved FAD binding motif [chemical binding]; other site 482957016984 phosphate binding motif [ion binding]; other site 482957016985 beta-alpha-beta structure motif; other site 482957016986 NAD binding pocket [chemical binding]; other site 482957016987 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 482957016988 trimer interface [polypeptide binding]; other site 482957016989 putative Zn binding site [ion binding]; other site 482957016990 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 482957016991 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 482957016992 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 482957016993 substrate binding site [chemical binding]; other site 482957016994 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 482957016995 substrate binding site [chemical binding]; other site 482957016996 ligand binding site [chemical binding]; other site 482957016997 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 482957016998 DTW domain; Region: DTW; cl01221 482957016999 conserved cys residue [active] 482957017000 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957017001 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 482957017002 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957017003 Ligand Binding Site [chemical binding]; other site 482957017004 amidase; Provisional; Region: PRK07486 482957017005 Amidase; Region: Amidase; cl11426 482957017006 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 482957017007 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 482957017008 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 482957017009 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 482957017010 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 482957017011 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 482957017012 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 482957017013 active site 1 [active] 482957017014 dimer interface [polypeptide binding]; other site 482957017015 hexamer interface [polypeptide binding]; other site 482957017016 active site 2 [active] 482957017017 aldolase II superfamily protein; Provisional; Region: PRK07044 482957017018 intersubunit interface [polypeptide binding]; other site 482957017019 active site 482957017020 Zn2+ binding site [ion binding]; other site 482957017021 Urea transporter; Region: UT; cl01829 482957017022 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 482957017023 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957017024 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 482957017025 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 482957017026 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 482957017027 short chain dehydrogenase; Provisional; Region: PRK07832 482957017028 classical (c) SDRs; Region: SDR_c; cd05233 482957017029 NAD(P) binding site [chemical binding]; other site 482957017030 active site 482957017031 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957017032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957017033 YhhN-like protein; Region: YhhN; pfam07947 482957017034 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 482957017035 oligomer interface [polypeptide binding]; other site 482957017036 putative active site [active] 482957017037 Mn binding site [ion binding]; other site 482957017038 Helix-turn-helix domain; Region: HTH_17; pfam12728 482957017039 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 482957017040 dimer interface [polypeptide binding]; other site 482957017041 active site 482957017042 coenzyme A binding site [chemical binding]; other site 482957017043 citrylCoA binding site [chemical binding]; other site 482957017044 Citrate synthase; Region: Citrate_synt; pfam00285 482957017045 oxalacetate/citrate binding site [chemical binding]; other site 482957017046 catalytic triad [active] 482957017047 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957017048 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957017049 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 482957017050 DNA-binding site [nucleotide binding]; DNA binding site 482957017051 RNA-binding motif; other site 482957017052 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957017053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957017054 substrate binding pocket [chemical binding]; other site 482957017055 membrane-bound complex binding site; other site 482957017056 hinge residues; other site 482957017057 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 482957017058 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 482957017059 DNA binding residues [nucleotide binding] 482957017060 putative dimer interface [polypeptide binding]; other site 482957017061 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 482957017062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957017063 Coenzyme A binding pocket [chemical binding]; other site 482957017064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017065 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957017067 dimerization interface [polypeptide binding]; other site 482957017068 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 482957017069 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 482957017070 NADP binding site [chemical binding]; other site 482957017071 dimer interface [polypeptide binding]; other site 482957017072 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 482957017073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017074 putative substrate translocation pore; other site 482957017075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017076 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 482957017077 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 482957017078 dimer interface [polypeptide binding]; other site 482957017079 ligand binding site [chemical binding]; other site 482957017080 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957017081 dimerization interface [polypeptide binding]; other site 482957017082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957017083 dimer interface [polypeptide binding]; other site 482957017084 putative CheW interface [polypeptide binding]; other site 482957017085 Part of AAA domain; Region: AAA_19; pfam13245 482957017086 Family description; Region: UvrD_C_2; pfam13538 482957017087 BetR domain; Region: BetR; pfam08667 482957017088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 482957017089 active site 482957017090 phosphorylation site [posttranslational modification] 482957017091 intermolecular recognition site; other site 482957017092 dimerization interface [polypeptide binding]; other site 482957017093 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957017094 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957017095 Ion channel; Region: Ion_trans_2; pfam07885 482957017096 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 482957017097 TrkA-N domain; Region: TrkA_N; pfam02254 482957017098 Transposase; Region: HTH_Tnp_1; cl17663 482957017099 HEXXH motif domain; Region: mod_HExxH; TIGR04267 482957017100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017101 H+ Antiporter protein; Region: 2A0121; TIGR00900 482957017102 putative substrate translocation pore; other site 482957017103 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 482957017104 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 482957017105 oligomer interface [polypeptide binding]; other site 482957017106 active site residues [active] 482957017107 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 482957017108 choline dehydrogenase; Validated; Region: PRK02106 482957017109 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957017110 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 482957017111 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957017112 NAD binding site [chemical binding]; other site 482957017113 catalytic residues [active] 482957017114 Cupin domain; Region: Cupin_2; pfam07883 482957017115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957017116 DNA binding residues [nucleotide binding] 482957017117 dimerization interface [polypeptide binding]; other site 482957017118 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 482957017119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957017120 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957017121 NAD(P) binding site [chemical binding]; other site 482957017122 active site 482957017123 Cupin; Region: Cupin_6; pfam12852 482957017124 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957017125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957017126 short chain dehydrogenase; Provisional; Region: PRK06180 482957017127 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957017128 NADP binding site [chemical binding]; other site 482957017129 active site 482957017130 steroid binding site; other site 482957017131 short chain dehydrogenase; Provisional; Region: PRK06180 482957017132 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957017133 NADP binding site [chemical binding]; other site 482957017134 active site 482957017135 steroid binding site; other site 482957017136 short chain dehydrogenase; Provisional; Region: PRK06180 482957017137 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957017138 NADP binding site [chemical binding]; other site 482957017139 active site 482957017140 steroid binding site; other site 482957017141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957017142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957017143 Flavin Reductases; Region: FlaRed; cl00801 482957017144 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957017145 catalytic loop [active] 482957017146 iron binding site [ion binding]; other site 482957017147 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 482957017148 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 482957017149 active site 482957017150 metal binding site [ion binding]; metal-binding site 482957017151 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 482957017152 active site 482957017153 metal binding site [ion binding]; metal-binding site 482957017154 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 482957017155 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 482957017156 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 482957017157 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 482957017158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957017159 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 482957017160 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 482957017161 acetaldehyde dehydrogenase; Validated; Region: PRK08300 482957017162 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 482957017163 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 482957017164 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 482957017165 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 482957017166 active site 482957017167 catalytic residues [active] 482957017168 metal binding site [ion binding]; metal-binding site 482957017169 DmpG-like communication domain; Region: DmpG_comm; pfam07836 482957017170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957017171 classical (c) SDRs; Region: SDR_c; cd05233 482957017172 NAD(P) binding site [chemical binding]; other site 482957017173 active site 482957017174 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957017175 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957017176 trimer interface [polypeptide binding]; other site 482957017177 eyelet of channel; other site 482957017178 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 482957017179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957017180 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017181 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017182 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957017183 putative effector binding pocket; other site 482957017184 dimerization interface [polypeptide binding]; other site 482957017185 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 482957017186 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957017187 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957017188 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 482957017189 Protein export membrane protein; Region: SecD_SecF; cl14618 482957017190 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 482957017191 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957017192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957017193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957017194 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 482957017195 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957017196 MarR family; Region: MarR_2; pfam12802 482957017197 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957017198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957017199 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 482957017200 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957017201 putative NAD(P) binding site [chemical binding]; other site 482957017202 putative dimer interface [polypeptide binding]; other site 482957017203 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 482957017204 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 482957017205 catalytic residues [active] 482957017206 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957017207 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957017208 trimer interface [polypeptide binding]; other site 482957017209 eyelet of channel; other site 482957017210 short chain dehydrogenase; Provisional; Region: PRK07576 482957017211 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 482957017212 NAD(P) binding site [chemical binding]; other site 482957017213 substrate binding site [chemical binding]; other site 482957017214 homotetramer interface [polypeptide binding]; other site 482957017215 active site 482957017216 homodimer interface [polypeptide binding]; other site 482957017217 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 482957017218 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 482957017219 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 482957017220 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 482957017221 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 482957017222 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 482957017223 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 482957017224 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 482957017225 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 482957017226 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 482957017227 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 482957017228 acyl-activating enzyme (AAE) consensus motif; other site 482957017229 putative AMP binding site [chemical binding]; other site 482957017230 putative active site [active] 482957017231 putative CoA binding site [chemical binding]; other site 482957017232 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 482957017233 AAA ATPase domain; Region: AAA_16; pfam13191 482957017234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957017235 DNA binding residues [nucleotide binding] 482957017236 dimerization interface [polypeptide binding]; other site 482957017237 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 482957017238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017240 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 482957017241 putative effector binding pocket; other site 482957017242 putative dimerization interface [polypeptide binding]; other site 482957017243 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957017244 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957017245 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957017246 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957017247 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957017248 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 482957017249 non-specific DNA interactions [nucleotide binding]; other site 482957017250 DNA binding site [nucleotide binding] 482957017251 sequence specific DNA binding site [nucleotide binding]; other site 482957017252 putative cAMP binding site [chemical binding]; other site 482957017253 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957017254 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957017255 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 482957017256 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957017257 short chain dehydrogenase; Provisional; Region: PRK07060 482957017258 classical (c) SDRs; Region: SDR_c; cd05233 482957017259 NAD(P) binding site [chemical binding]; other site 482957017260 active site 482957017261 SnoaL-like domain; Region: SnoaL_4; pfam13577 482957017262 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957017263 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957017264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957017265 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 482957017266 NAD(P) binding site [chemical binding]; other site 482957017267 active site 482957017268 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 482957017269 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957017270 Di-iron ligands [ion binding]; other site 482957017271 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957017272 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 482957017273 catalytic loop [active] 482957017274 iron binding site [ion binding]; other site 482957017275 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213 482957017276 FAD binding pocket [chemical binding]; other site 482957017277 FAD binding motif [chemical binding]; other site 482957017278 phosphate binding motif [ion binding]; other site 482957017279 beta-alpha-beta structure motif; other site 482957017280 NAD binding pocket [chemical binding]; other site 482957017281 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957017282 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957017283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957017284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957017285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957017286 H-NS histone family; Region: Histone_HNS; pfam00816 482957017287 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 482957017288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957017289 non-specific DNA binding site [nucleotide binding]; other site 482957017290 salt bridge; other site 482957017291 sequence-specific DNA binding site [nucleotide binding]; other site 482957017292 Cupin domain; Region: Cupin_2; pfam07883 482957017293 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957017294 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957017295 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 482957017296 classical (c) SDRs; Region: SDR_c; cd05233 482957017297 NAD(P) binding site [chemical binding]; other site 482957017298 active site 482957017299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017301 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 482957017302 substrate binding pocket [chemical binding]; other site 482957017303 dimerization interface [polypeptide binding]; other site 482957017304 salicylate hydroxylase; Provisional; Region: PRK08163 482957017305 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957017306 S-formylglutathione hydrolase; Region: PLN02442 482957017307 Putative esterase; Region: Esterase; pfam00756 482957017308 OpgC protein; Region: OpgC_C; pfam10129 482957017309 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957017310 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957017311 trimer interface [polypeptide binding]; other site 482957017312 eyelet of channel; other site 482957017313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017315 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957017316 putative effector binding pocket; other site 482957017317 putative dimerization interface [polypeptide binding]; other site 482957017318 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957017319 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957017320 active site 482957017321 catalytic tetrad [active] 482957017322 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 482957017323 active site 482957017324 hypothetical protein; Provisional; Region: PRK06761 482957017325 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 482957017326 CoenzymeA binding site [chemical binding]; other site 482957017327 subunit interaction site [polypeptide binding]; other site 482957017328 PHB binding site; other site 482957017329 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957017330 MarR family; Region: MarR_2; pfam12802 482957017331 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957017332 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 482957017333 FMN binding site [chemical binding]; other site 482957017334 active site 482957017335 substrate binding site [chemical binding]; other site 482957017336 catalytic residue [active] 482957017337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017339 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 482957017340 putative dimerization interface [polypeptide binding]; other site 482957017341 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957017342 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 482957017343 Peptidase family M23; Region: Peptidase_M23; pfam01551 482957017344 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 482957017345 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957017346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017347 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957017348 substrate binding pocket [chemical binding]; other site 482957017349 dimerization interface [polypeptide binding]; other site 482957017350 Predicted membrane protein [Function unknown]; Region: COG2261 482957017351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 482957017352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957017353 Walker A/P-loop; other site 482957017354 ATP binding site [chemical binding]; other site 482957017355 Q-loop/lid; other site 482957017356 ABC transporter signature motif; other site 482957017357 Walker B; other site 482957017358 D-loop; other site 482957017359 H-loop/switch region; other site 482957017360 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 482957017361 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957017362 Walker A/P-loop; other site 482957017363 ATP binding site [chemical binding]; other site 482957017364 Q-loop/lid; other site 482957017365 ABC transporter signature motif; other site 482957017366 Walker B; other site 482957017367 D-loop; other site 482957017368 H-loop/switch region; other site 482957017369 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 482957017370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957017371 dimer interface [polypeptide binding]; other site 482957017372 conserved gate region; other site 482957017373 putative PBP binding loops; other site 482957017374 ABC-ATPase subunit interface; other site 482957017375 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 482957017376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957017377 dimer interface [polypeptide binding]; other site 482957017378 conserved gate region; other site 482957017379 putative PBP binding loops; other site 482957017380 ABC-ATPase subunit interface; other site 482957017381 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 482957017382 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 482957017383 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 482957017384 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 482957017385 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957017386 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 482957017387 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 482957017388 Cupin; Region: Cupin_1; smart00835 482957017389 Cupin; Region: Cupin_1; smart00835 482957017390 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 482957017391 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 482957017392 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 482957017393 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 482957017394 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957017395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017396 putative substrate translocation pore; other site 482957017397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017400 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957017401 putative effector binding pocket; other site 482957017402 dimerization interface [polypeptide binding]; other site 482957017403 Fusaric acid resistance protein family; Region: FUSC; pfam04632 482957017404 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 482957017405 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 482957017406 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 482957017407 putative molybdopterin cofactor binding site [chemical binding]; other site 482957017408 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 482957017409 putative molybdopterin cofactor binding site; other site 482957017410 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957017411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957017412 DNA-binding site [nucleotide binding]; DNA binding site 482957017413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957017414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957017415 homodimer interface [polypeptide binding]; other site 482957017416 catalytic residue [active] 482957017417 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 482957017418 Mechanosensitive ion channel; Region: MS_channel; pfam00924 482957017419 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 482957017420 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 482957017421 Sulfate transporter family; Region: Sulfate_transp; pfam00916 482957017422 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 482957017423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957017426 dimerization interface [polypeptide binding]; other site 482957017427 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957017428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017429 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957017430 putative substrate translocation pore; other site 482957017431 Isochorismatase family; Region: Isochorismatase; pfam00857 482957017432 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 482957017433 catalytic triad [active] 482957017434 conserved cis-peptide bond; other site 482957017435 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957017436 MarR family; Region: MarR; pfam01047 482957017437 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 482957017438 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 482957017439 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 482957017440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017441 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957017442 dimerization interface [polypeptide binding]; other site 482957017443 substrate binding pocket [chemical binding]; other site 482957017444 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 482957017445 magnesium-transporting ATPase; Provisional; Region: PRK15122 482957017446 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 482957017447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 482957017448 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 482957017449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957017450 motif II; other site 482957017451 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 482957017452 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 482957017453 active site 482957017454 catalytic triad [active] 482957017455 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 482957017456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957017457 substrate binding pocket [chemical binding]; other site 482957017458 membrane-bound complex binding site; other site 482957017459 hinge residues; other site 482957017460 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 482957017461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017462 putative substrate translocation pore; other site 482957017463 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 482957017464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957017465 Repair protein; Region: Repair_PSII; pfam04536 482957017466 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 482957017467 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 482957017468 Transglycosylase; Region: Transgly; pfam00912 482957017469 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 482957017470 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 482957017471 Bacterial Ig-like domain; Region: Big_5; pfam13205 482957017472 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 482957017473 MG2 domain; Region: A2M_N; pfam01835 482957017474 Alpha-2-macroglobulin family; Region: A2M; pfam00207 482957017475 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 482957017476 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 482957017477 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 482957017478 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957017479 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957017480 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957017481 Cytochrome c; Region: Cytochrom_C; pfam00034 482957017482 Predicted membrane protein [Function unknown]; Region: COG2259 482957017483 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957017484 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957017485 trimer interface [polypeptide binding]; other site 482957017486 eyelet of channel; other site 482957017487 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957017488 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957017489 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957017490 metal binding site [ion binding]; metal-binding site 482957017491 putative dimer interface [polypeptide binding]; other site 482957017492 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 482957017493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017494 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957017495 dimerization interface [polypeptide binding]; other site 482957017496 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 482957017497 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 482957017498 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 482957017499 Cl- selectivity filter; other site 482957017500 Cl- binding residues [ion binding]; other site 482957017501 pore gating glutamate residue; other site 482957017502 dimer interface [polypeptide binding]; other site 482957017503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 482957017504 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957017505 MarR family; Region: MarR_2; pfam12802 482957017506 MarR family; Region: MarR_2; cl17246 482957017507 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 482957017508 HPP family; Region: HPP; pfam04982 482957017509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 482957017510 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 482957017511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017513 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957017514 putative effector binding pocket; other site 482957017515 dimerization interface [polypeptide binding]; other site 482957017516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017517 D-galactonate transporter; Region: 2A0114; TIGR00893 482957017518 putative substrate translocation pore; other site 482957017519 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 482957017520 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 482957017521 putative ligand binding site [chemical binding]; other site 482957017522 NAD binding site [chemical binding]; other site 482957017523 catalytic site [active] 482957017524 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 482957017525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017526 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 482957017527 putative dimerization interface [polypeptide binding]; other site 482957017528 putative substrate binding pocket [chemical binding]; other site 482957017529 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 482957017530 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 482957017531 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 482957017532 DctM-like transporters; Region: DctM; pfam06808 482957017533 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 482957017534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957017535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957017536 DNA binding site [nucleotide binding] 482957017537 domain linker motif; other site 482957017538 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 482957017539 putative dimerization interface [polypeptide binding]; other site 482957017540 putative ligand binding site [chemical binding]; other site 482957017541 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 482957017542 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 482957017543 putative ligand binding site [chemical binding]; other site 482957017544 putative NAD binding site [chemical binding]; other site 482957017545 catalytic site [active] 482957017546 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 482957017547 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 482957017548 active site 482957017549 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 482957017550 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957017551 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957017552 substrate binding pocket [chemical binding]; other site 482957017553 membrane-bound complex binding site; other site 482957017554 hinge residues; other site 482957017555 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957017556 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 482957017557 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 482957017558 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957017559 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957017560 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957017561 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 482957017562 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 482957017563 active site 482957017564 AMP binding site [chemical binding]; other site 482957017565 homodimer interface [polypeptide binding]; other site 482957017566 acyl-activating enzyme (AAE) consensus motif; other site 482957017567 CoA binding site [chemical binding]; other site 482957017568 enoyl-CoA hydratase; Provisional; Region: PRK05995 482957017569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957017570 substrate binding site [chemical binding]; other site 482957017571 oxyanion hole (OAH) forming residues; other site 482957017572 trimer interface [polypeptide binding]; other site 482957017573 MarC family integral membrane protein; Region: MarC; cl00919 482957017574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957017575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957017576 active site 482957017577 catalytic tetrad [active] 482957017578 CAAX protease self-immunity; Region: Abi; pfam02517 482957017579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957017580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957017581 ATP binding site [chemical binding]; other site 482957017582 Mg2+ binding site [ion binding]; other site 482957017583 G-X-G motif; other site 482957017584 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 482957017585 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 482957017586 putative NAD(P) binding site [chemical binding]; other site 482957017587 catalytic Zn binding site [ion binding]; other site 482957017588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957017589 Coenzyme A binding pocket [chemical binding]; other site 482957017590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017591 putative substrate translocation pore; other site 482957017592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957017593 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 482957017594 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 482957017595 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957017596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957017597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957017598 Coenzyme A binding pocket [chemical binding]; other site 482957017599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957017600 DNA-binding site [nucleotide binding]; DNA binding site 482957017601 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957017602 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957017603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957017604 homodimer interface [polypeptide binding]; other site 482957017605 catalytic residue [active] 482957017606 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 482957017607 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 482957017608 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 482957017609 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957017610 protein binding site [polypeptide binding]; other site 482957017611 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 482957017612 protein binding site [polypeptide binding]; other site 482957017613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017614 putative substrate translocation pore; other site 482957017615 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 482957017616 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 482957017617 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957017618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957017619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957017620 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 482957017621 putative uracil binding site [chemical binding]; other site 482957017622 putative active site [active] 482957017623 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 482957017624 NMT1-like family; Region: NMT1_2; pfam13379 482957017625 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 482957017626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957017627 active site 482957017628 phosphorylation site [posttranslational modification] 482957017629 intermolecular recognition site; other site 482957017630 dimerization interface [polypeptide binding]; other site 482957017631 ANTAR domain; Region: ANTAR; pfam03861 482957017632 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 482957017633 active site 482957017634 SAM binding site [chemical binding]; other site 482957017635 homodimer interface [polypeptide binding]; other site 482957017636 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 482957017637 nitrite reductase subunit NirD; Provisional; Region: PRK14989 482957017638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957017639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957017640 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 482957017641 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 482957017642 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 482957017643 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 482957017644 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 482957017645 [4Fe-4S] binding site [ion binding]; other site 482957017646 molybdopterin cofactor binding site; other site 482957017647 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 482957017648 molybdopterin cofactor binding site; other site 482957017649 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 482957017650 Flavodoxin; Region: Flavodoxin_1; pfam00258 482957017651 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 482957017652 FAD binding pocket [chemical binding]; other site 482957017653 FAD binding motif [chemical binding]; other site 482957017654 catalytic residues [active] 482957017655 NAD binding pocket [chemical binding]; other site 482957017656 phosphate binding motif [ion binding]; other site 482957017657 beta-alpha-beta structure motif; other site 482957017658 short chain dehydrogenase; Provisional; Region: PRK09291 482957017659 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 482957017660 NADP binding site [chemical binding]; other site 482957017661 active site 482957017662 steroid binding site; other site 482957017663 Domain of unknown function (DUF336); Region: DUF336; pfam03928 482957017664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017666 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 482957017667 putative effector binding pocket; other site 482957017668 putative dimerization interface [polypeptide binding]; other site 482957017669 Predicted integral membrane protein [Function unknown]; Region: COG0392 482957017670 Uncharacterized conserved protein [Function unknown]; Region: COG2898 482957017671 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 482957017672 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 482957017673 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 482957017674 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 482957017675 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 482957017676 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 482957017677 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957017678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957017679 DNA-binding site [nucleotide binding]; DNA binding site 482957017680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957017681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957017682 homodimer interface [polypeptide binding]; other site 482957017683 catalytic residue [active] 482957017684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017685 D-galactonate transporter; Region: 2A0114; TIGR00893 482957017686 putative substrate translocation pore; other site 482957017687 mannonate dehydratase; Provisional; Region: PRK03906 482957017688 mannonate dehydratase; Region: uxuA; TIGR00695 482957017689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957017690 DNA-binding site [nucleotide binding]; DNA binding site 482957017691 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957017692 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 482957017693 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957017694 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957017695 HAMP domain; Region: HAMP; pfam00672 482957017696 dimerization interface [polypeptide binding]; other site 482957017697 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957017698 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957017699 metal binding site [ion binding]; metal-binding site 482957017700 active site 482957017701 I-site; other site 482957017702 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957017703 D-serine dehydratase; Provisional; Region: PRK02991 482957017704 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 482957017705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957017706 catalytic residue [active] 482957017707 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957017708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017709 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957017710 dimerization interface [polypeptide binding]; other site 482957017711 substrate binding pocket [chemical binding]; other site 482957017712 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 482957017713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957017715 dimerization interface [polypeptide binding]; other site 482957017716 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957017717 aromatic amino acid exporter; Provisional; Region: PRK11689 482957017718 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957017719 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 482957017720 NAD(P) binding site [chemical binding]; other site 482957017721 catalytic residues [active] 482957017722 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957017723 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 482957017724 inhibitor site; inhibition site 482957017725 active site 482957017726 dimer interface [polypeptide binding]; other site 482957017727 catalytic residue [active] 482957017728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017729 putative substrate translocation pore; other site 482957017730 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 482957017731 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957017732 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957017733 Transcriptional regulators [Transcription]; Region: GntR; COG1802 482957017734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957017735 DNA-binding site [nucleotide binding]; DNA binding site 482957017736 FCD domain; Region: FCD; pfam07729 482957017737 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 482957017738 active site 482957017739 metal binding site [ion binding]; metal-binding site 482957017740 RNA polymerase sigma factor; Reviewed; Region: PRK05602 482957017741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957017742 Heavy-metal resistance; Region: Metal_resist; pfam13801 482957017743 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 482957017744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 482957017745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 482957017746 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 482957017747 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 482957017748 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957017749 acyl-activating enzyme (AAE) consensus motif; other site 482957017750 AMP binding site [chemical binding]; other site 482957017751 active site 482957017752 CoA binding site [chemical binding]; other site 482957017753 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 482957017754 putative active site [active] 482957017755 putative catalytic site [active] 482957017756 poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839 482957017757 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 482957017758 Phasin protein; Region: Phasin_2; pfam09361 482957017759 poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240 482957017760 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 482957017761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 482957017762 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957017763 DNA binding residues [nucleotide binding] 482957017764 dimerization interface [polypeptide binding]; other site 482957017765 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 482957017766 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 482957017767 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957017768 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957017769 acyl-coenzyme A oxidase; Region: PLN02526 482957017770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957017771 active site 482957017772 acetoacetate decarboxylase; Provisional; Region: PRK02265 482957017773 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957017774 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957017775 Cytochrome c; Region: Cytochrom_C; cl11414 482957017776 Cytochrome c; Region: Cytochrom_C; cl11414 482957017777 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957017778 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957017779 Cytochrome c; Region: Cytochrom_C; pfam00034 482957017780 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 482957017781 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 482957017782 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 482957017783 Putative D-pathway homolog; other site 482957017784 Low-spin heme binding site [chemical binding]; other site 482957017785 Subunit I/II interface [polypeptide binding]; other site 482957017786 Putative Q-pathway; other site 482957017787 Putative alternate electron transfer pathway; other site 482957017788 Putative water exit pathway; other site 482957017789 Binuclear center (active site) [active] 482957017790 Putative K-pathway homolog; other site 482957017791 Putative proton exit pathway; other site 482957017792 Subunit I/IIa interface [polypeptide binding]; other site 482957017793 Electron transfer pathway; other site 482957017794 Cytochrome c; Region: Cytochrom_C; cl11414 482957017795 Cytochrome c; Region: Cytochrom_C; cl11414 482957017796 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 482957017797 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 482957017798 Int/Topo IB signature motif; other site 482957017799 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957017800 classical (c) SDRs; Region: SDR_c; cd05233 482957017801 NAD(P) binding site [chemical binding]; other site 482957017802 active site 482957017803 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 482957017804 dimerization interface [polypeptide binding]; other site 482957017805 DNA binding residues [nucleotide binding] 482957017806 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 482957017807 putative transporter; Provisional; Region: PRK10504 482957017808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017809 putative substrate translocation pore; other site 482957017810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957017814 dimerization interface [polypeptide binding]; other site 482957017815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957017816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 482957017817 active site 482957017818 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 482957017819 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 482957017820 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 482957017821 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957017822 Flavin binding site [chemical binding]; other site 482957017823 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 482957017824 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 482957017825 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 482957017826 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 482957017827 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 482957017828 FAD binding pocket [chemical binding]; other site 482957017829 FAD binding motif [chemical binding]; other site 482957017830 phosphate binding motif [ion binding]; other site 482957017831 beta-alpha-beta structure motif; other site 482957017832 NAD(p) ribose binding residues [chemical binding]; other site 482957017833 NAD binding pocket [chemical binding]; other site 482957017834 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 482957017835 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957017836 catalytic loop [active] 482957017837 iron binding site [ion binding]; other site 482957017838 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 482957017839 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957017840 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 482957017841 acyl-activating enzyme (AAE) consensus motif; other site 482957017842 acyl-activating enzyme (AAE) consensus motif; other site 482957017843 putative AMP binding site [chemical binding]; other site 482957017844 putative active site [active] 482957017845 putative CoA binding site [chemical binding]; other site 482957017846 CoA binding site [chemical binding]; other site 482957017847 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 482957017848 classical (c) SDRs; Region: SDR_c; cd05233 482957017849 NAD(P) binding site [chemical binding]; other site 482957017850 active site 482957017851 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 482957017852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957017853 DNA-binding site [nucleotide binding]; DNA binding site 482957017854 UTRA domain; Region: UTRA; pfam07702 482957017855 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 482957017856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957017857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957017858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957017859 dimerization interface [polypeptide binding]; other site 482957017860 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 482957017861 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957017862 metal binding site [ion binding]; metal-binding site 482957017863 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 482957017864 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957017865 Na binding site [ion binding]; other site 482957017866 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 482957017867 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 482957017868 DNA binding site [nucleotide binding] 482957017869 active site 482957017870 Int/Topo IB signature motif; other site 482957017871 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 482957017872 oligomeric interface; other site 482957017873 homodimer interface [polypeptide binding]; other site 482957017874 putative active site [active] 482957017875 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 482957017876 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 482957017877 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 482957017878 active site 482957017879 Fe binding site [ion binding]; other site 482957017880 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 482957017881 Coenzyme A transferase; Region: CoA_trans; cl17247 482957017882 enoyl-CoA hydratase; Provisional; Region: PRK08290 482957017883 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957017884 substrate binding site [chemical binding]; other site 482957017885 oxyanion hole (OAH) forming residues; other site 482957017886 trimer interface [polypeptide binding]; other site 482957017887 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 482957017888 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957017889 FMN binding site [chemical binding]; other site 482957017890 substrate binding site [chemical binding]; other site 482957017891 putative catalytic residue [active] 482957017892 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957017893 enoyl-CoA hydratase; Provisional; Region: PRK06495 482957017894 substrate binding site [chemical binding]; other site 482957017895 oxyanion hole (OAH) forming residues; other site 482957017896 trimer interface [polypeptide binding]; other site 482957017897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957017898 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 482957017899 FAD binding site [chemical binding]; other site 482957017900 substrate binding site [chemical binding]; other site 482957017901 catalytic base [active] 482957017902 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957017903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957017904 active site 482957017905 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 482957017906 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957017907 dimer interface [polypeptide binding]; other site 482957017908 active site 482957017909 short chain dehydrogenase; Provisional; Region: PRK07791 482957017910 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 482957017911 homodimer interface [polypeptide binding]; other site 482957017912 NAD binding site [chemical binding]; other site 482957017913 active site 482957017914 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957017915 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957017916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957017917 active site 482957017918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957017919 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957017920 active site 482957017921 short chain dehydrogenase; Provisional; Region: PRK07831 482957017922 classical (c) SDRs; Region: SDR_c; cd05233 482957017923 NAD(P) binding site [chemical binding]; other site 482957017924 active site 482957017925 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 482957017926 putative active site [active] 482957017927 putative catalytic site [active] 482957017928 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 482957017929 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957017930 dimer interface [polypeptide binding]; other site 482957017931 active site 482957017932 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 482957017933 Protein export membrane protein; Region: SecD_SecF; cl14618 482957017934 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957017935 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 482957017936 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 482957017937 DNA-binding site [nucleotide binding]; DNA binding site 482957017938 RNA-binding motif; other site 482957017939 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 482957017940 rRNA binding site [nucleotide binding]; other site 482957017941 predicted 30S ribosome binding site; other site 482957017942 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957017943 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 482957017944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957017945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957017946 NAD(P) binding site [chemical binding]; other site 482957017947 active site 482957017948 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 482957017949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957017950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957017951 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957017952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957017953 putative substrate translocation pore; other site 482957017954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957017955 Uncharacterized conserved protein [Function unknown]; Region: COG5361 482957017956 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 482957017957 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 482957017958 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 482957017959 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 482957017960 active site 482957017961 catalytic residues [active] 482957017962 metal binding site [ion binding]; metal-binding site 482957017963 DmpG-like communication domain; Region: DmpG_comm; pfam07836 482957017964 acetaldehyde dehydrogenase; Validated; Region: PRK08300 482957017965 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 482957017966 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 482957017967 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 482957017968 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 482957017969 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 482957017970 short chain dehydrogenase; Provisional; Region: PRK07856 482957017971 classical (c) SDRs; Region: SDR_c; cd05233 482957017972 NAD(P) binding site [chemical binding]; other site 482957017973 active site 482957017974 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 482957017975 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957017976 catalytic site [active] 482957017977 short chain dehydrogenase; Provisional; Region: PRK06114 482957017978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957017979 NAD(P) binding site [chemical binding]; other site 482957017980 active site 482957017981 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 482957017982 Ligand binding site [chemical binding]; other site 482957017983 Electron transfer flavoprotein domain; Region: ETF; pfam01012 482957017984 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 482957017985 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 482957017986 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 482957017987 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 482957017988 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 482957017989 putative trimer interface [polypeptide binding]; other site 482957017990 putative metal binding site [ion binding]; other site 482957017991 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957017992 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957017993 trimer interface [polypeptide binding]; other site 482957017994 eyelet of channel; other site 482957017995 Predicted membrane protein [Function unknown]; Region: COG2364 482957017996 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 482957017997 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957017998 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957017999 active site 482957018000 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 482957018001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957018002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957018003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957018004 dimerization interface [polypeptide binding]; other site 482957018005 Cupin domain; Region: Cupin_2; cl17218 482957018006 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957018007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957018008 putative DNA binding site [nucleotide binding]; other site 482957018009 putative Zn2+ binding site [ion binding]; other site 482957018010 AsnC family; Region: AsnC_trans_reg; pfam01037 482957018011 LysE type translocator; Region: LysE; pfam01810 482957018012 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957018013 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957018014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957018015 WHG domain; Region: WHG; pfam13305 482957018016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957018017 Coenzyme A binding pocket [chemical binding]; other site 482957018018 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 482957018019 dimerization interface [polypeptide binding]; other site 482957018020 putative DNA binding site [nucleotide binding]; other site 482957018021 putative Zn2+ binding site [ion binding]; other site 482957018022 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 482957018023 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957018024 hypothetical protein; Provisional; Region: PRK06834 482957018025 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957018026 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957018027 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 482957018028 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957018029 N-terminal plug; other site 482957018030 ligand-binding site [chemical binding]; other site 482957018031 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957018032 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957018033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018034 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 482957018035 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957018036 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 482957018037 putative NAD(P) binding site [chemical binding]; other site 482957018038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018039 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 482957018040 NAD(P) binding site [chemical binding]; other site 482957018041 active site 482957018042 hypothetical protein; Provisional; Region: PRK06194 482957018043 classical (c) SDRs; Region: SDR_c; cd05233 482957018044 NAD(P) binding site [chemical binding]; other site 482957018045 active site 482957018046 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 482957018047 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 482957018048 tetramer interface [polypeptide binding]; other site 482957018049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957018050 catalytic residue [active] 482957018051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 482957018052 YheO-like PAS domain; Region: PAS_6; pfam08348 482957018053 HTH domain; Region: HTH_22; pfam13309 482957018054 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 482957018055 putative deacylase active site [active] 482957018056 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957018057 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957018058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957018059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957018060 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 482957018061 Proline dehydrogenase; Region: Pro_dh; cl03282 482957018062 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 482957018063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957018064 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 482957018065 nudix motif; other site 482957018066 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 482957018067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957018068 Coenzyme A binding pocket [chemical binding]; other site 482957018069 EthD domain; Region: EthD; pfam07110 482957018070 SnoaL-like domain; Region: SnoaL_4; pfam13577 482957018071 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 482957018072 short chain dehydrogenase; Provisional; Region: PRK08303 482957018073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018074 NAD(P) binding site [chemical binding]; other site 482957018075 active site 482957018076 classical (c) SDRs; Region: SDR_c; cd05233 482957018077 NAD(P) binding site [chemical binding]; other site 482957018078 active site 482957018079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018080 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957018081 NAD(P) binding site [chemical binding]; other site 482957018082 active site 482957018083 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 482957018084 active site 482957018085 substrate-binding site [chemical binding]; other site 482957018086 metal-binding site [ion binding] 482957018087 GTP binding site [chemical binding]; other site 482957018088 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 482957018089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018090 NAD(P) binding site [chemical binding]; other site 482957018091 active site 482957018092 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957018093 classical (c) SDRs; Region: SDR_c; cd05233 482957018094 NAD(P) binding site [chemical binding]; other site 482957018095 active site 482957018096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018097 short chain dehydrogenase; Validated; Region: PRK07069 482957018098 NAD(P) binding site [chemical binding]; other site 482957018099 active site 482957018100 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957018101 classical (c) SDRs; Region: SDR_c; cd05233 482957018102 NAD(P) binding site [chemical binding]; other site 482957018103 active site 482957018104 SnoaL-like domain; Region: SnoaL_4; pfam13577 482957018105 hypothetical protein; Validated; Region: PRK07121 482957018106 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 482957018107 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 482957018108 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 482957018109 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 482957018110 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 482957018111 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957018112 Walker A motif; other site 482957018113 ATP binding site [chemical binding]; other site 482957018114 Walker B motif; other site 482957018115 arginine finger; other site 482957018116 Peptidase family M41; Region: Peptidase_M41; pfam01434 482957018117 OsmC-like protein; Region: OsmC; pfam02566 482957018118 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 482957018119 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 482957018120 active site 482957018121 homotetramer interface [polypeptide binding]; other site 482957018122 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 482957018123 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 482957018124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957018125 dimerization interface [polypeptide binding]; other site 482957018126 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957018127 dimer interface [polypeptide binding]; other site 482957018128 putative CheW interface [polypeptide binding]; other site 482957018129 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 482957018130 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957018131 N-terminal plug; other site 482957018132 ligand-binding site [chemical binding]; other site 482957018133 riboflavin synthase subunit beta; Provisional; Region: PRK12419 482957018134 active site 482957018135 homopentamer interface [polypeptide binding]; other site 482957018136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957018137 MarR family; Region: MarR; pfam01047 482957018138 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 482957018139 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957018140 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 482957018141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957018142 substrate binding pocket [chemical binding]; other site 482957018143 membrane-bound complex binding site; other site 482957018144 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 482957018145 active site 482957018146 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 482957018147 dimer interface [polypeptide binding]; other site 482957018148 non-prolyl cis peptide bond; other site 482957018149 insertion regions; other site 482957018150 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957018151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957018152 substrate binding pocket [chemical binding]; other site 482957018153 membrane-bound complex binding site; other site 482957018154 hinge residues; other site 482957018155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957018156 conserved gate region; other site 482957018157 dimer interface [polypeptide binding]; other site 482957018158 putative PBP binding loops; other site 482957018159 ABC-ATPase subunit interface; other site 482957018160 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 482957018161 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957018162 Walker A/P-loop; other site 482957018163 ATP binding site [chemical binding]; other site 482957018164 Q-loop/lid; other site 482957018165 ABC transporter signature motif; other site 482957018166 Walker B; other site 482957018167 D-loop; other site 482957018168 H-loop/switch region; other site 482957018169 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 482957018170 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 482957018171 active site 482957018172 non-prolyl cis peptide bond; other site 482957018173 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 482957018174 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 482957018175 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 482957018176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957018177 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957018178 substrate binding pocket [chemical binding]; other site 482957018179 membrane-bound complex binding site; other site 482957018180 hinge residues; other site 482957018181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957018182 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957018183 Coenzyme A binding pocket [chemical binding]; other site 482957018184 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 482957018185 toxin interface [polypeptide binding]; other site 482957018186 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 482957018187 Zn binding site [ion binding]; other site 482957018188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957018189 non-specific DNA binding site [nucleotide binding]; other site 482957018190 salt bridge; other site 482957018191 sequence-specific DNA binding site [nucleotide binding]; other site 482957018192 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 482957018193 peptide binding site [polypeptide binding]; other site 482957018194 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 482957018195 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 482957018196 putative active site [active] 482957018197 Zn binding site [ion binding]; other site 482957018198 PAS domain; Region: PAS; smart00091 482957018199 PAS fold; Region: PAS_7; pfam12860 482957018200 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957018201 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957018202 metal binding site [ion binding]; metal-binding site 482957018203 active site 482957018204 I-site; other site 482957018205 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957018206 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957018207 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957018208 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957018209 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 482957018210 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957018211 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957018212 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957018213 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 482957018214 putative outer membrane lipoprotein; Provisional; Region: PRK09967 482957018215 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957018216 ligand binding site [chemical binding]; other site 482957018217 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957018218 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957018219 trimer interface [polypeptide binding]; other site 482957018220 eyelet of channel; other site 482957018221 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 482957018222 putative dimer interface [polypeptide binding]; other site 482957018223 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957018224 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957018225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957018226 DNA binding residues [nucleotide binding] 482957018227 dimerization interface [polypeptide binding]; other site 482957018228 amidase; Provisional; Region: PRK07869 482957018229 Amidase; Region: Amidase; cl11426 482957018230 Prostaglandin dehydrogenases; Region: PGDH; cd05288 482957018231 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 482957018232 NAD(P) binding site [chemical binding]; other site 482957018233 substrate binding site [chemical binding]; other site 482957018234 dimer interface [polypeptide binding]; other site 482957018235 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 482957018236 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 482957018237 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 482957018238 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957018239 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 482957018240 conserved cys residue [active] 482957018241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018243 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 482957018244 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 482957018245 FMN binding site [chemical binding]; other site 482957018246 substrate binding site [chemical binding]; other site 482957018247 putative catalytic residue [active] 482957018248 MoxR-like ATPases [General function prediction only]; Region: COG0714 482957018249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957018250 Walker A motif; other site 482957018251 ATP binding site [chemical binding]; other site 482957018252 Walker B motif; other site 482957018253 arginine finger; other site 482957018254 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 482957018255 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 482957018256 metal ion-dependent adhesion site (MIDAS); other site 482957018257 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 482957018258 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 482957018259 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 482957018260 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 482957018261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957018262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957018263 dimer interface [polypeptide binding]; other site 482957018264 phosphorylation site [posttranslational modification] 482957018265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957018266 ATP binding site [chemical binding]; other site 482957018267 Mg2+ binding site [ion binding]; other site 482957018268 G-X-G motif; other site 482957018269 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957018270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957018271 active site 482957018272 phosphorylation site [posttranslational modification] 482957018273 intermolecular recognition site; other site 482957018274 dimerization interface [polypeptide binding]; other site 482957018275 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 482957018276 DNA binding site [nucleotide binding] 482957018277 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 482957018278 peptidase domain interface [polypeptide binding]; other site 482957018279 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 482957018280 active site 482957018281 catalytic triad [active] 482957018282 calcium binding site [ion binding]; other site 482957018283 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957018284 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957018285 active site 482957018286 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 482957018287 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 482957018288 Isochorismatase family; Region: Isochorismatase; pfam00857 482957018289 catalytic triad [active] 482957018290 conserved cis-peptide bond; other site 482957018291 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 482957018292 Glutamine amidotransferase class-I; Region: GATase; pfam00117 482957018293 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 482957018294 glutamine binding [chemical binding]; other site 482957018295 catalytic triad [active] 482957018296 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 482957018297 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 482957018298 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 482957018299 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 482957018300 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 482957018301 Leucine carboxyl methyltransferase; Region: LCM; cl01306 482957018302 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 482957018303 Prostaglandin dehydrogenases; Region: PGDH; cd05288 482957018304 NAD(P) binding site [chemical binding]; other site 482957018305 substrate binding site [chemical binding]; other site 482957018306 dimer interface [polypeptide binding]; other site 482957018307 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 482957018308 Helix-turn-helix domain; Region: HTH_28; pfam13518 482957018309 Winged helix-turn helix; Region: HTH_29; pfam13551 482957018310 Homeodomain-like domain; Region: HTH_32; pfam13565 482957018311 Integrase core domain; Region: rve; pfam00665 482957018312 PAAR motif; Region: PAAR_motif; pfam05488 482957018313 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 482957018314 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 482957018315 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 482957018316 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 482957018317 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957018318 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957018319 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 482957018320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957018321 Walker A motif; other site 482957018322 ATP binding site [chemical binding]; other site 482957018323 Walker B motif; other site 482957018324 arginine finger; other site 482957018325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957018326 Walker A motif; other site 482957018327 ATP binding site [chemical binding]; other site 482957018328 Walker B motif; other site 482957018329 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 482957018330 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 482957018331 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 482957018332 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 482957018333 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 482957018334 Protein of unknown function (DUF796); Region: DUF796; pfam05638 482957018335 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 482957018336 Protein of unknown function (DUF877); Region: DUF877; pfam05943 482957018337 Protein of unknown function (DUF770); Region: DUF770; pfam05591 482957018338 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 482957018339 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 482957018340 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 482957018341 Catalytic domain of Protein Kinases; Region: PKc; cd00180 482957018342 active site 482957018343 ATP binding site [chemical binding]; other site 482957018344 substrate binding site [chemical binding]; other site 482957018345 activation loop (A-loop); other site 482957018346 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 482957018347 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 482957018348 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 482957018349 G1 box; other site 482957018350 GTP/Mg2+ binding site [chemical binding]; other site 482957018351 G2 box; other site 482957018352 G3 box; other site 482957018353 Switch II region; other site 482957018354 G4 box; other site 482957018355 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 482957018356 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 482957018357 hypothetical protein; Provisional; Region: PRK07033 482957018358 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 482957018359 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957018360 ligand binding site [chemical binding]; other site 482957018361 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 482957018362 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 482957018363 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 482957018364 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 482957018365 phosphopeptide binding site; other site 482957018366 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957018367 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957018368 metal binding site [ion binding]; metal-binding site 482957018369 active site 482957018370 I-site; other site 482957018371 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957018372 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 482957018373 tetramerization interface [polypeptide binding]; other site 482957018374 NAD(P) binding site [chemical binding]; other site 482957018375 catalytic residues [active] 482957018376 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957018377 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 482957018378 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957018379 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 482957018380 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957018381 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 482957018382 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957018383 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 482957018384 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 482957018385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957018386 catalytic loop [active] 482957018387 iron binding site [ion binding]; other site 482957018388 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 482957018389 Uncharacterized conserved protein [Function unknown]; Region: COG1359 482957018390 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 482957018391 Prostaglandin dehydrogenases; Region: PGDH; cd05288 482957018392 NAD(P) binding site [chemical binding]; other site 482957018393 substrate binding site [chemical binding]; other site 482957018394 dimer interface [polypeptide binding]; other site 482957018395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957018396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957018397 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 482957018398 Papain-like cysteine protease AvrRpt2; Region: Peptidase_C70; pfam12385 482957018399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957018400 dimerization interface [polypeptide binding]; other site 482957018401 Histidine kinase; Region: HisKA_3; pfam07730 482957018402 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 482957018403 ATP binding site [chemical binding]; other site 482957018404 Mg2+ binding site [ion binding]; other site 482957018405 G-X-G motif; other site 482957018406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957018407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957018408 active site 482957018409 phosphorylation site [posttranslational modification] 482957018410 intermolecular recognition site; other site 482957018411 dimerization interface [polypeptide binding]; other site 482957018412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957018413 DNA binding residues [nucleotide binding] 482957018414 dimerization interface [polypeptide binding]; other site 482957018415 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 482957018416 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 482957018417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018418 putative substrate translocation pore; other site 482957018419 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 482957018420 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 482957018421 tetramer interface [polypeptide binding]; other site 482957018422 active site 482957018423 Mg2+/Mn2+ binding site [ion binding]; other site 482957018424 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 482957018425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957018426 active site 482957018427 benzoate transport; Region: 2A0115; TIGR00895 482957018428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018429 putative substrate translocation pore; other site 482957018430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957018431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957018432 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957018433 dimerization interface [polypeptide binding]; other site 482957018434 substrate binding pocket [chemical binding]; other site 482957018435 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 482957018436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 482957018437 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957018438 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 482957018439 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 482957018440 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 482957018441 dimerization interface [polypeptide binding]; other site 482957018442 active site 482957018443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957018444 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957018445 salt bridge; other site 482957018446 non-specific DNA binding site [nucleotide binding]; other site 482957018447 sequence-specific DNA binding site [nucleotide binding]; other site 482957018448 HipA N-terminal domain; Region: Couple_hipA; cl11853 482957018449 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 482957018450 HipA-like N-terminal domain; Region: HipA_N; pfam07805 482957018451 HipA-like C-terminal domain; Region: HipA_C; pfam07804 482957018452 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957018453 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 482957018454 active site 482957018455 FMN binding site [chemical binding]; other site 482957018456 substrate binding site [chemical binding]; other site 482957018457 putative catalytic residue [active] 482957018458 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 482957018459 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 482957018460 dimer interface [polypeptide binding]; other site 482957018461 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 482957018462 active site 482957018463 Fe binding site [ion binding]; other site 482957018464 shikimate transporter; Provisional; Region: PRK09952 482957018465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018466 putative substrate translocation pore; other site 482957018467 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 482957018468 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 482957018469 putative active site [active] 482957018470 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 482957018471 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 482957018472 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957018473 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 482957018474 DEAD_2; Region: DEAD_2; pfam06733 482957018475 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 482957018476 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 482957018477 MltA-interacting protein MipA; Region: MipA; cl01504 482957018478 FOG: CBS domain [General function prediction only]; Region: COG0517 482957018479 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 482957018480 PRC-barrel domain; Region: PRC; pfam05239 482957018481 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 482957018482 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 482957018483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957018484 putative active site [active] 482957018485 heme pocket [chemical binding]; other site 482957018486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957018487 dimer interface [polypeptide binding]; other site 482957018488 phosphorylation site [posttranslational modification] 482957018489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957018490 ATP binding site [chemical binding]; other site 482957018491 Mg2+ binding site [ion binding]; other site 482957018492 G-X-G motif; other site 482957018493 Response regulator receiver domain; Region: Response_reg; pfam00072 482957018494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957018495 active site 482957018496 phosphorylation site [posttranslational modification] 482957018497 intermolecular recognition site; other site 482957018498 dimerization interface [polypeptide binding]; other site 482957018499 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 482957018500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957018501 Walker A motif; other site 482957018502 ATP binding site [chemical binding]; other site 482957018503 Walker B motif; other site 482957018504 arginine finger; other site 482957018505 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957018506 Cache domain; Region: Cache_1; pfam02743 482957018507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957018508 dimerization interface [polypeptide binding]; other site 482957018509 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957018510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957018511 dimer interface [polypeptide binding]; other site 482957018512 putative CheW interface [polypeptide binding]; other site 482957018513 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 482957018514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957018515 Ligand Binding Site [chemical binding]; other site 482957018516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957018517 Ligand Binding Site [chemical binding]; other site 482957018518 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 482957018519 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 482957018520 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 482957018521 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 482957018522 active site residue [active] 482957018523 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 482957018524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957018525 Ligand Binding Site [chemical binding]; other site 482957018526 PAS domain S-box; Region: sensory_box; TIGR00229 482957018527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957018528 putative active site [active] 482957018529 heme pocket [chemical binding]; other site 482957018530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 482957018531 Histidine kinase; Region: HisKA_3; pfam07730 482957018532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957018533 ATP binding site [chemical binding]; other site 482957018534 Mg2+ binding site [ion binding]; other site 482957018535 G-X-G motif; other site 482957018536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957018537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957018538 active site 482957018539 phosphorylation site [posttranslational modification] 482957018540 intermolecular recognition site; other site 482957018541 dimerization interface [polypeptide binding]; other site 482957018542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957018543 DNA binding residues [nucleotide binding] 482957018544 dimerization interface [polypeptide binding]; other site 482957018545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 482957018546 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 482957018547 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 482957018548 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 482957018549 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957018550 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 482957018551 Transglycosylase; Region: Transgly; pfam00912 482957018552 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 482957018553 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 482957018554 Proline racemase; Region: Pro_racemase; pfam05544 482957018555 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957018556 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957018557 dimerization interface [polypeptide binding]; other site 482957018558 ligand binding site [chemical binding]; other site 482957018559 Transcriptional regulators [Transcription]; Region: FadR; COG2186 482957018560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957018561 DNA-binding site [nucleotide binding]; DNA binding site 482957018562 FCD domain; Region: FCD; pfam07729 482957018563 ornithine cyclodeaminase; Validated; Region: PRK07340 482957018564 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 482957018565 Response regulator receiver domain; Region: Response_reg; pfam00072 482957018566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957018567 active site 482957018568 phosphorylation site [posttranslational modification] 482957018569 intermolecular recognition site; other site 482957018570 dimerization interface [polypeptide binding]; other site 482957018571 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 482957018572 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957018573 ligand binding site [chemical binding]; other site 482957018574 flexible hinge region; other site 482957018575 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 482957018576 putative switch regulator; other site 482957018577 non-specific DNA interactions [nucleotide binding]; other site 482957018578 DNA binding site [nucleotide binding] 482957018579 sequence specific DNA binding site [nucleotide binding]; other site 482957018580 putative cAMP binding site [chemical binding]; other site 482957018581 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 482957018582 Protein of unknown function, DUF488; Region: DUF488; cl01246 482957018583 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 482957018584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957018585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957018586 homodimer interface [polypeptide binding]; other site 482957018587 catalytic residue [active] 482957018588 aromatic amino acid transporter; Provisional; Region: PRK10238 482957018589 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957018590 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 482957018591 putative DNA binding site [nucleotide binding]; other site 482957018592 putative Zn2+ binding site [ion binding]; other site 482957018593 AsnC family; Region: AsnC_trans_reg; pfam01037 482957018594 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 482957018595 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 482957018596 EamA-like transporter family; Region: EamA; pfam00892 482957018597 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957018598 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 482957018599 Domain of unknown function (DUF1924); Region: DUF1924; pfam09086 482957018600 Methyltransferase domain; Region: Methyltransf_31; pfam13847 482957018601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957018602 S-adenosylmethionine binding site [chemical binding]; other site 482957018603 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 482957018604 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 482957018605 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 482957018606 putative ion selectivity filter; other site 482957018607 putative pore gating glutamate residue; other site 482957018608 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957018609 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957018610 trimer interface [polypeptide binding]; other site 482957018611 eyelet of channel; other site 482957018612 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957018613 transcriptional regulator; Provisional; Region: PRK10632 482957018614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957018615 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957018616 putative effector binding pocket; other site 482957018617 dimerization interface [polypeptide binding]; other site 482957018618 Fusaric acid resistance protein family; Region: FUSC; pfam04632 482957018619 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 482957018620 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 482957018621 homodimer interface [polypeptide binding]; other site 482957018622 homotetramer interface [polypeptide binding]; other site 482957018623 active site pocket [active] 482957018624 cleavage site 482957018625 amino acid transporter; Region: 2A0306; TIGR00909 482957018626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957018627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957018628 DNA binding residues [nucleotide binding] 482957018629 dimerization interface [polypeptide binding]; other site 482957018630 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 482957018631 Cytochrome P450; Region: p450; cl12078 482957018632 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957018633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018634 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 482957018635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957018636 DNA-binding site [nucleotide binding]; DNA binding site 482957018637 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 482957018638 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957018639 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957018640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957018641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957018642 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 482957018643 putative dimerization interface [polypeptide binding]; other site 482957018644 Predicted permeases [General function prediction only]; Region: COG0679 482957018645 EamA-like transporter family; Region: EamA; pfam00892 482957018646 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 482957018647 EamA-like transporter family; Region: EamA; pfam00892 482957018648 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 482957018649 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 482957018650 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 482957018651 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 482957018652 tetrameric interface [polypeptide binding]; other site 482957018653 NAD binding site [chemical binding]; other site 482957018654 catalytic residues [active] 482957018655 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 482957018656 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957018657 inhibitor-cofactor binding pocket; inhibition site 482957018658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957018659 catalytic residue [active] 482957018660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957018661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957018662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957018663 dimerization interface [polypeptide binding]; other site 482957018664 H+ Antiporter protein; Region: 2A0121; TIGR00900 482957018665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018666 putative substrate translocation pore; other site 482957018667 MarR family; Region: MarR; pfam01047 482957018668 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 482957018669 Epoxide hydrolase N terminus; Region: EHN; pfam06441 482957018670 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957018671 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957018672 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957018673 conserved cys residue [active] 482957018674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018675 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 482957018676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018677 NAD(P) binding site [chemical binding]; other site 482957018678 active site 482957018679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957018680 PAS fold; Region: PAS_3; pfam08447 482957018681 putative active site [active] 482957018682 heme pocket [chemical binding]; other site 482957018683 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957018684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957018685 metal binding site [ion binding]; metal-binding site 482957018686 active site 482957018687 I-site; other site 482957018688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018689 putative substrate translocation pore; other site 482957018690 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 482957018691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018692 putative substrate translocation pore; other site 482957018693 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 482957018694 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957018695 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 482957018696 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957018697 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957018698 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957018699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957018700 putative DNA binding site [nucleotide binding]; other site 482957018701 putative Zn2+ binding site [ion binding]; other site 482957018702 AsnC family; Region: AsnC_trans_reg; pfam01037 482957018703 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957018704 voltage-gated potassium channel; Provisional; Region: PRK10537 482957018705 Ion channel; Region: Ion_trans_2; pfam07885 482957018706 TrkA-N domain; Region: TrkA_N; pfam02254 482957018707 Predicted membrane protein [Function unknown]; Region: COG1238 482957018708 benzoate transport; Region: 2A0115; TIGR00895 482957018709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018711 putative substrate translocation pore; other site 482957018712 Putative cyclase; Region: Cyclase; cl00814 482957018713 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957018714 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957018715 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 482957018716 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957018717 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957018718 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 482957018719 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957018720 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957018721 trimer interface [polypeptide binding]; other site 482957018722 eyelet of channel; other site 482957018723 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 482957018724 2-methylcitrate dehydratase; Region: prpD; TIGR02330 482957018725 acyl-CoA synthetase; Validated; Region: PRK08162 482957018726 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 482957018727 acyl-activating enzyme (AAE) consensus motif; other site 482957018728 putative active site [active] 482957018729 AMP binding site [chemical binding]; other site 482957018730 putative CoA binding site [chemical binding]; other site 482957018731 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 482957018732 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957018733 ligand binding site [chemical binding]; other site 482957018734 flexible hinge region; other site 482957018735 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 482957018736 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 482957018737 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 482957018738 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957018739 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957018740 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 482957018741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957018742 active site 482957018743 phosphorylation site [posttranslational modification] 482957018744 intermolecular recognition site; other site 482957018745 dimerization interface [polypeptide binding]; other site 482957018746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957018747 DNA binding site [nucleotide binding] 482957018748 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 482957018749 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 482957018750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957018751 dimer interface [polypeptide binding]; other site 482957018752 phosphorylation site [posttranslational modification] 482957018753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957018754 ATP binding site [chemical binding]; other site 482957018755 Mg2+ binding site [ion binding]; other site 482957018756 G-X-G motif; other site 482957018757 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957018758 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957018759 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957018760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957018763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018764 NAD(P) binding site [chemical binding]; other site 482957018765 active site 482957018766 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 482957018767 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 482957018768 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957018769 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 482957018770 active site 482957018771 FMN binding site [chemical binding]; other site 482957018772 substrate binding site [chemical binding]; other site 482957018773 homotetramer interface [polypeptide binding]; other site 482957018774 catalytic residue [active] 482957018775 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 482957018776 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 482957018777 potential catalytic triad [active] 482957018778 conserved cys residue [active] 482957018779 short chain dehydrogenase; Provisional; Region: PRK06500 482957018780 classical (c) SDRs; Region: SDR_c; cd05233 482957018781 NAD(P) binding site [chemical binding]; other site 482957018782 active site 482957018783 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 482957018784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957018785 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957018786 dimerization interface [polypeptide binding]; other site 482957018787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957018788 DNA-binding site [nucleotide binding]; DNA binding site 482957018789 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957018790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957018791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957018792 homodimer interface [polypeptide binding]; other site 482957018793 catalytic residue [active] 482957018794 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957018795 Uncharacterized conserved protein [Function unknown]; Region: COG2128 482957018796 Cupin domain; Region: Cupin_2; cl17218 482957018797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957018798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957018799 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957018800 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 482957018801 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 482957018802 Walker A/P-loop; other site 482957018803 ATP binding site [chemical binding]; other site 482957018804 Q-loop/lid; other site 482957018805 ABC transporter signature motif; other site 482957018806 Walker B; other site 482957018807 D-loop; other site 482957018808 H-loop/switch region; other site 482957018809 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 482957018810 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 482957018811 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 482957018812 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 482957018813 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957018814 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957018815 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957018816 trimer interface [polypeptide binding]; other site 482957018817 eyelet of channel; other site 482957018818 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 482957018819 active site lid residues [active] 482957018820 substrate binding pocket [chemical binding]; other site 482957018821 catalytic residues [active] 482957018822 substrate-Mg2+ binding site; other site 482957018823 aspartate-rich region 1; other site 482957018824 aspartate-rich region 2; other site 482957018825 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 482957018826 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 482957018827 putative active site [active] 482957018828 catalytic site [active] 482957018829 putative metal binding site [ion binding]; other site 482957018830 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 482957018831 active site residue [active] 482957018832 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 482957018833 active site residue [active] 482957018834 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 482957018835 active site residue [active] 482957018836 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 482957018837 active site residue [active] 482957018838 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 482957018839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957018840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957018841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957018842 dimerization interface [polypeptide binding]; other site 482957018843 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957018844 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957018845 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957018846 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 482957018847 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 482957018848 dimer interface [polypeptide binding]; other site 482957018849 active site 482957018850 non-prolyl cis peptide bond; other site 482957018851 insertion regions; other site 482957018852 hypothetical protein; Provisional; Region: PRK06208 482957018853 active site 482957018854 intersubunit interface [polypeptide binding]; other site 482957018855 Zn2+ binding site [ion binding]; other site 482957018856 NMT1-like family; Region: NMT1_2; pfam13379 482957018857 NMT1/THI5 like; Region: NMT1; pfam09084 482957018858 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957018859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957018860 dimer interface [polypeptide binding]; other site 482957018861 conserved gate region; other site 482957018862 putative PBP binding loops; other site 482957018863 ABC-ATPase subunit interface; other site 482957018864 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 482957018865 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957018866 Walker A/P-loop; other site 482957018867 ATP binding site [chemical binding]; other site 482957018868 Q-loop/lid; other site 482957018869 ABC transporter signature motif; other site 482957018870 Walker B; other site 482957018871 D-loop; other site 482957018872 H-loop/switch region; other site 482957018873 Cytochrome c; Region: Cytochrom_C; pfam00034 482957018874 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957018875 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957018876 membrane-bound complex binding site; other site 482957018877 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 482957018878 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 482957018879 MOSC domain; Region: MOSC; pfam03473 482957018880 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 482957018881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 482957018882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957018883 dimer interface [polypeptide binding]; other site 482957018884 phosphorylation site [posttranslational modification] 482957018885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957018886 ATP binding site [chemical binding]; other site 482957018887 Mg2+ binding site [ion binding]; other site 482957018888 G-X-G motif; other site 482957018889 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 482957018890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957018891 active site 482957018892 phosphorylation site [posttranslational modification] 482957018893 intermolecular recognition site; other site 482957018894 dimerization interface [polypeptide binding]; other site 482957018895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957018896 DNA binding site [nucleotide binding] 482957018897 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 482957018898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957018899 putative substrate translocation pore; other site 482957018900 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957018901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957018902 DNA-binding site [nucleotide binding]; DNA binding site 482957018903 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957018904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957018905 homodimer interface [polypeptide binding]; other site 482957018906 catalytic residue [active] 482957018907 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 482957018908 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 482957018909 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 482957018910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957018911 dimer interface [polypeptide binding]; other site 482957018912 conserved gate region; other site 482957018913 ABC-ATPase subunit interface; other site 482957018914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957018915 dimer interface [polypeptide binding]; other site 482957018916 conserved gate region; other site 482957018917 putative PBP binding loops; other site 482957018918 ABC-ATPase subunit interface; other site 482957018919 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 482957018920 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 482957018921 Walker A/P-loop; other site 482957018922 ATP binding site [chemical binding]; other site 482957018923 Q-loop/lid; other site 482957018924 ABC transporter signature motif; other site 482957018925 Walker B; other site 482957018926 D-loop; other site 482957018927 H-loop/switch region; other site 482957018928 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957018929 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957018930 trimer interface [polypeptide binding]; other site 482957018931 eyelet of channel; other site 482957018932 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957018933 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 482957018934 NAD(P) binding site [chemical binding]; other site 482957018935 Cupin domain; Region: Cupin_2; cl17218 482957018936 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957018937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957018938 Helix-turn-helix domain; Region: HTH_17; cl17695 482957018939 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 482957018940 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 482957018941 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 482957018942 putative substrate binding pocket [chemical binding]; other site 482957018943 trimer interface [polypeptide binding]; other site 482957018944 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 482957018945 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 482957018946 putative active site [active] 482957018947 putative metal binding site [ion binding]; other site 482957018948 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 482957018949 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 482957018950 NAD binding site [chemical binding]; other site 482957018951 catalytic residues [active] 482957018952 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 482957018953 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957018954 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 482957018955 MarR family; Region: MarR_2; cl17246 482957018956 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957018957 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 482957018958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957018959 NAD(P) binding site [chemical binding]; other site 482957018960 active site 482957018961 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 482957018962 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 482957018963 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 482957018964 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 482957018965 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 482957018966 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 482957018967 ligand binding site [chemical binding]; other site 482957018968 short chain dehydrogenase; Provisional; Region: PRK07074 482957018969 classical (c) SDRs; Region: SDR_c; cd05233 482957018970 NAD(P) binding site [chemical binding]; other site 482957018971 active site 482957018972 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 482957018973 putative cation:proton antiport protein; Provisional; Region: PRK10669 482957018974 TrkA-N domain; Region: TrkA_N; pfam02254 482957018975 Cytochrome c; Region: Cytochrom_C; pfam00034 482957018976 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957018977 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957018978 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 482957018979 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 482957018980 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957018981 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 482957018982 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 482957018983 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 482957018984 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 482957018985 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 482957018986 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 482957018987 hexamer interface [polypeptide binding]; other site 482957018988 ligand binding site [chemical binding]; other site 482957018989 putative active site [active] 482957018990 NAD(P) binding site [chemical binding]; other site 482957018991 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 482957018992 hypothetical protein; Provisional; Region: PRK08609 482957018993 active site 482957018994 primer binding site [nucleotide binding]; other site 482957018995 NTP binding site [chemical binding]; other site 482957018996 metal binding triad [ion binding]; metal-binding site 482957018997 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 482957018998 active site 482957018999 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 482957019000 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 482957019001 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 482957019002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957019003 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 482957019004 Bacterial sugar transferase; Region: Bac_transf; pfam02397 482957019005 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 482957019006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957019007 ligand binding site [chemical binding]; other site 482957019008 flexible hinge region; other site 482957019009 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 482957019010 non-specific DNA interactions [nucleotide binding]; other site 482957019011 DNA binding site [nucleotide binding] 482957019012 sequence specific DNA binding site [nucleotide binding]; other site 482957019013 putative cAMP binding site [chemical binding]; other site 482957019014 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 482957019015 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957019016 ligand binding site [chemical binding]; other site 482957019017 flexible hinge region; other site 482957019018 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 482957019019 acyl carrier protein; Provisional; Region: PRK07081 482957019020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957019021 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957019022 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957019023 active site 482957019024 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 482957019025 dimer interface [polypeptide binding]; other site 482957019026 motif 1; other site 482957019027 active site 482957019028 motif 2; other site 482957019029 motif 3; other site 482957019030 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 482957019031 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 482957019032 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957019033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957019034 Walker A motif; other site 482957019035 ATP binding site [chemical binding]; other site 482957019036 Walker B motif; other site 482957019037 arginine finger; other site 482957019038 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957019039 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957019040 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 482957019041 putative ADP-binding pocket [chemical binding]; other site 482957019042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957019043 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 482957019044 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 482957019045 Substrate binding site; other site 482957019046 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 482957019047 Right handed beta helix region; Region: Beta_helix; pfam13229 482957019048 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 482957019049 Acyltransferase family; Region: Acyl_transf_3; pfam01757 482957019050 Chain length determinant protein; Region: Wzz; pfam02706 482957019051 tyrosine kinase; Provisional; Region: PRK11519 482957019052 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 482957019053 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 482957019054 Nucleotide binding site [chemical binding]; other site 482957019055 P loop; other site 482957019056 DTAP/Switch II; other site 482957019057 Switch I; other site 482957019058 polysaccharide export protein Wza; Provisional; Region: PRK15078 482957019059 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 482957019060 SLBB domain; Region: SLBB; pfam10531 482957019061 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 482957019062 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 482957019063 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 482957019064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 482957019065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 482957019066 active site 482957019067 Probable beta-xylosidase; Provisional; Region: PLN03080 482957019068 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 482957019069 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 482957019070 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 482957019071 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 482957019072 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 482957019073 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 482957019074 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 482957019075 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 482957019076 RHS Repeat; Region: RHS_repeat; pfam05593 482957019077 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 482957019078 RHS Repeat; Region: RHS_repeat; pfam05593 482957019079 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 482957019080 RHS Repeat; Region: RHS_repeat; cl11982 482957019081 RHS Repeat; Region: RHS_repeat; pfam05593 482957019082 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 482957019083 RHS protein; Region: RHS; pfam03527 482957019084 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 482957019085 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 482957019086 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957019087 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957019088 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 482957019089 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 482957019090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957019092 dimerization interface [polypeptide binding]; other site 482957019093 Protein of unknown function DUF2625; Region: DUF2625; pfam10946 482957019094 Uncharacterized conserved protein [Function unknown]; Region: COG1739 482957019095 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 482957019096 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 482957019097 H-NS histone family; Region: Histone_HNS; pfam00816 482957019098 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 482957019099 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 482957019100 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 482957019101 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 482957019102 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957019103 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 482957019104 putative acyl-acceptor binding pocket; other site 482957019105 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 482957019106 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 482957019107 putative active site [active] 482957019108 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957019109 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 482957019110 Walker A/P-loop; other site 482957019111 ATP binding site [chemical binding]; other site 482957019112 Q-loop/lid; other site 482957019113 ABC transporter signature motif; other site 482957019114 Walker B; other site 482957019115 D-loop; other site 482957019116 H-loop/switch region; other site 482957019117 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 482957019118 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 482957019119 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 482957019120 multimer interface [polypeptide binding]; other site 482957019121 active site 482957019122 catalytic triad [active] 482957019123 dimer interface [polypeptide binding]; other site 482957019124 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 482957019125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957019126 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 482957019127 Walker A motif; other site 482957019128 ATP binding site [chemical binding]; other site 482957019129 Walker B motif; other site 482957019130 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 482957019131 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 482957019132 metal ion-dependent adhesion site (MIDAS); other site 482957019133 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 482957019134 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 482957019135 ligand binding site [chemical binding]; other site 482957019136 regulator interaction site; other site 482957019137 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 482957019138 ANTAR domain; Region: ANTAR; pfam03861 482957019139 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957019140 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 482957019141 haloalkane dehalogenase; Provisional; Region: PRK00870 482957019142 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 482957019143 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 482957019144 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 482957019145 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 482957019146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 482957019147 ATP binding site [chemical binding]; other site 482957019148 putative Mg++ binding site [ion binding]; other site 482957019149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957019150 nucleotide binding region [chemical binding]; other site 482957019151 ATP-binding site [chemical binding]; other site 482957019152 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 482957019153 DEAD/H associated; Region: DEAD_assoc; pfam08494 482957019154 putative transporter; Provisional; Region: PRK11021 482957019155 putative transporter; Provisional; Region: PRK11021 482957019156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 482957019157 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 482957019158 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 482957019159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957019161 dimerization interface [polypeptide binding]; other site 482957019162 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957019163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957019164 non-specific DNA binding site [nucleotide binding]; other site 482957019165 salt bridge; other site 482957019166 sequence-specific DNA binding site [nucleotide binding]; other site 482957019167 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 482957019168 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 482957019169 heterodimer interface [polypeptide binding]; other site 482957019170 multimer interface [polypeptide binding]; other site 482957019171 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 482957019172 active site 482957019173 protocatechuate 3,4-dioxygenase, alpha subunit; Region: protocat_alph; TIGR02423 482957019174 active site 482957019175 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957019176 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957019177 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957019178 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 482957019179 SxDxEG motif; other site 482957019180 active site 482957019181 metal binding site [ion binding]; metal-binding site 482957019182 homopentamer interface [polypeptide binding]; other site 482957019183 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 482957019184 homodimer interface [polypeptide binding]; other site 482957019185 homotetramer interface [polypeptide binding]; other site 482957019186 active site pocket [active] 482957019187 cleavage site 482957019188 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 482957019189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957019190 dimer interface [polypeptide binding]; other site 482957019191 conserved gate region; other site 482957019192 putative PBP binding loops; other site 482957019193 ABC-ATPase subunit interface; other site 482957019194 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 482957019195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957019196 dimer interface [polypeptide binding]; other site 482957019197 conserved gate region; other site 482957019198 putative PBP binding loops; other site 482957019199 ABC-ATPase subunit interface; other site 482957019200 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 482957019201 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 482957019202 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 482957019203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957019204 Walker A/P-loop; other site 482957019205 ATP binding site [chemical binding]; other site 482957019206 Q-loop/lid; other site 482957019207 ABC transporter signature motif; other site 482957019208 Walker B; other site 482957019209 D-loop; other site 482957019210 H-loop/switch region; other site 482957019211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 482957019212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 482957019213 Walker A/P-loop; other site 482957019214 ATP binding site [chemical binding]; other site 482957019215 Q-loop/lid; other site 482957019216 ABC transporter signature motif; other site 482957019217 Walker B; other site 482957019218 D-loop; other site 482957019219 H-loop/switch region; other site 482957019220 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 482957019221 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 482957019222 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 482957019223 catalytic nucleophile [active] 482957019224 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 482957019225 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 482957019226 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 482957019227 putative active site [active] 482957019228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019229 D-galactonate transporter; Region: 2A0114; TIGR00893 482957019230 putative substrate translocation pore; other site 482957019231 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 482957019232 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 482957019233 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 482957019234 putative active site [active] 482957019235 putative catalytic site [active] 482957019236 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957019237 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957019238 trimer interface [polypeptide binding]; other site 482957019239 eyelet of channel; other site 482957019240 BCCT family transporter; Region: BCCT; pfam02028 482957019241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957019242 S-adenosylmethionine binding site [chemical binding]; other site 482957019243 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 482957019244 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 482957019245 active site 482957019246 metal binding site [ion binding]; metal-binding site 482957019247 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 482957019248 Cytochrome c; Region: Cytochrom_C; pfam00034 482957019249 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957019250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957019251 DNA-binding site [nucleotide binding]; DNA binding site 482957019252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957019253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957019254 homodimer interface [polypeptide binding]; other site 482957019255 catalytic residue [active] 482957019256 Sulphur transport; Region: Sulf_transp; pfam04143 482957019257 Predicted transporter component [General function prediction only]; Region: COG2391 482957019258 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 482957019259 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957019260 dimerization interface [polypeptide binding]; other site 482957019261 putative DNA binding site [nucleotide binding]; other site 482957019262 putative Zn2+ binding site [ion binding]; other site 482957019263 benzoate transport; Region: 2A0115; TIGR00895 482957019264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019265 putative substrate translocation pore; other site 482957019266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019267 salicylate hydroxylase; Provisional; Region: PRK08163 482957019268 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957019269 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 482957019270 maleylacetoacetate isomerase; Region: maiA; TIGR01262 482957019271 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 482957019272 dimer interface [polypeptide binding]; other site 482957019273 N-terminal domain interface [polypeptide binding]; other site 482957019274 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 482957019275 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 482957019276 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 482957019277 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 482957019278 Cupin domain; Region: Cupin_2; pfam07883 482957019279 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957019282 dimerization interface [polypeptide binding]; other site 482957019283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 482957019284 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 482957019285 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957019286 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957019287 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 482957019288 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 482957019289 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957019290 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 482957019291 inhibitor site; inhibition site 482957019292 active site 482957019293 dimer interface [polypeptide binding]; other site 482957019294 catalytic residue [active] 482957019295 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 482957019296 Spore germination protein; Region: Spore_permease; cl17796 482957019297 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 482957019298 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 482957019299 dimer interface [polypeptide binding]; other site 482957019300 NADP binding site [chemical binding]; other site 482957019301 catalytic residues [active] 482957019302 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 482957019303 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 482957019304 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 482957019305 Bacterial SH3 domain; Region: SH3_3; pfam08239 482957019306 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 482957019307 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 482957019308 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 482957019309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957019310 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 482957019311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957019312 DNA binding residues [nucleotide binding] 482957019313 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 482957019314 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 482957019315 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 482957019316 DNA binding residues [nucleotide binding] 482957019317 putative dimer interface [polypeptide binding]; other site 482957019318 putative metal binding residues [ion binding]; other site 482957019319 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 482957019320 MarR family; Region: MarR_2; cl17246 482957019321 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957019322 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957019323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019324 putative substrate translocation pore; other site 482957019325 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 482957019326 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 482957019327 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 482957019328 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 482957019329 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 482957019330 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 482957019331 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 482957019332 active site 482957019333 metal-binding site 482957019334 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 482957019335 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 482957019336 tetramer interface [polypeptide binding]; other site 482957019337 active site 482957019338 Mg2+/Mn2+ binding site [ion binding]; other site 482957019339 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 482957019340 active site 482957019341 metal-binding site 482957019342 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957019343 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 482957019344 PYR/PP interface [polypeptide binding]; other site 482957019345 dimer interface [polypeptide binding]; other site 482957019346 TPP binding site [chemical binding]; other site 482957019347 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 482957019348 TPP-binding site; other site 482957019349 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957019350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957019351 catalytic residue [active] 482957019352 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957019353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957019354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957019355 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 482957019356 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 482957019357 dimer interface [polypeptide binding]; other site 482957019358 active site 482957019359 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 482957019360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 482957019361 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 482957019362 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 482957019363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957019364 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957019365 dimerization interface [polypeptide binding]; other site 482957019366 DNA binding residues [nucleotide binding] 482957019367 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 482957019368 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 482957019369 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 482957019370 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 482957019371 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 482957019372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 482957019373 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 482957019374 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 482957019375 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 482957019376 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 482957019377 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 482957019378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 482957019379 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 482957019380 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 482957019381 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 482957019382 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 482957019383 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 482957019384 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 482957019385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 482957019386 Uncharacterized conserved protein [Function unknown]; Region: COG2308 482957019387 cell density-dependent motility repressor; Provisional; Region: PRK10082 482957019388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957019390 dimerization interface [polypeptide binding]; other site 482957019391 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 482957019392 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 482957019393 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 482957019394 putative active site [active] 482957019395 putative metal binding site [ion binding]; other site 482957019396 N-glycosyltransferase; Provisional; Region: PRK11204 482957019397 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 482957019398 DXD motif; other site 482957019399 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 482957019400 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 482957019401 glutaminase active site [active] 482957019402 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 482957019403 dimer interface [polypeptide binding]; other site 482957019404 active site 482957019405 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 482957019406 dimer interface [polypeptide binding]; other site 482957019407 active site 482957019408 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 482957019409 Cytochrome c; Region: Cytochrom_C; pfam00034 482957019410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957019411 Coenzyme A binding pocket [chemical binding]; other site 482957019412 allantoate amidohydrolase; Reviewed; Region: PRK12891 482957019413 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 482957019414 active site 482957019415 metal binding site [ion binding]; metal-binding site 482957019416 dimer interface [polypeptide binding]; other site 482957019417 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 482957019418 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957019419 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957019420 dimerization interface [polypeptide binding]; other site 482957019421 ligand binding site [chemical binding]; other site 482957019422 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957019423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019424 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957019425 dimerization interface [polypeptide binding]; other site 482957019426 substrate binding pocket [chemical binding]; other site 482957019427 peroxiredoxin; Region: AhpC; TIGR03137 482957019428 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 482957019429 dimer interface [polypeptide binding]; other site 482957019430 decamer (pentamer of dimers) interface [polypeptide binding]; other site 482957019431 catalytic triad [active] 482957019432 peroxidatic and resolving cysteines [active] 482957019433 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 482957019434 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 482957019435 catalytic residue [active] 482957019436 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 482957019437 catalytic residues [active] 482957019438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957019439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957019440 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 482957019441 hypothetical protein; Provisional; Region: PRK07483 482957019442 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 482957019443 inhibitor-cofactor binding pocket; inhibition site 482957019444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957019445 catalytic residue [active] 482957019446 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 482957019447 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 482957019448 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957019449 Walker A/P-loop; other site 482957019450 ATP binding site [chemical binding]; other site 482957019451 Q-loop/lid; other site 482957019452 ABC transporter signature motif; other site 482957019453 Walker B; other site 482957019454 D-loop; other site 482957019455 H-loop/switch region; other site 482957019456 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957019457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957019458 dimer interface [polypeptide binding]; other site 482957019459 conserved gate region; other site 482957019460 putative PBP binding loops; other site 482957019461 ABC-ATPase subunit interface; other site 482957019462 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957019463 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957019464 substrate binding pocket [chemical binding]; other site 482957019465 membrane-bound complex binding site; other site 482957019466 hinge residues; other site 482957019467 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 482957019468 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957019469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957019470 Walker A/P-loop; other site 482957019471 ATP binding site [chemical binding]; other site 482957019472 Q-loop/lid; other site 482957019473 ABC transporter signature motif; other site 482957019474 Walker B; other site 482957019475 D-loop; other site 482957019476 H-loop/switch region; other site 482957019477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957019478 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 482957019479 Walker A/P-loop; other site 482957019480 ATP binding site [chemical binding]; other site 482957019481 Q-loop/lid; other site 482957019482 ABC transporter signature motif; other site 482957019483 Walker B; other site 482957019484 D-loop; other site 482957019485 H-loop/switch region; other site 482957019486 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957019487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019488 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957019489 dimerization interface [polypeptide binding]; other site 482957019490 MAPEG family; Region: MAPEG; cl09190 482957019491 alanine racemase; Reviewed; Region: PRK13340 482957019492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 482957019493 active site 482957019494 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957019495 substrate binding site [chemical binding]; other site 482957019496 catalytic residues [active] 482957019497 dimer interface [polypeptide binding]; other site 482957019498 enoyl-CoA hydratase; Validated; Region: PRK08139 482957019499 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957019500 substrate binding site [chemical binding]; other site 482957019501 oxyanion hole (OAH) forming residues; other site 482957019502 trimer interface [polypeptide binding]; other site 482957019503 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 482957019504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019506 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957019507 putative effector binding pocket; other site 482957019508 dimerization interface [polypeptide binding]; other site 482957019509 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 482957019510 dimer interface [polypeptide binding]; other site 482957019511 FMN binding site [chemical binding]; other site 482957019512 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957019513 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 482957019514 putative NAD(P) binding site [chemical binding]; other site 482957019515 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 482957019516 SnoaL-like domain; Region: SnoaL_3; pfam13474 482957019517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019519 The C-terminal substrate binding domain of LysR-type transcriptional regulator ToxR regulates the expression of the toxoflavin biosynthesis genes; contains the type 2 periplasmic bindinig fold; Region: PBP2_ToxR; cd08465 482957019520 putative substrate binding pocket [chemical binding]; other site 482957019521 putative dimerization interface [polypeptide binding]; other site 482957019522 Protein of unknown function, DUF606; Region: DUF606; pfam04657 482957019523 Response regulator receiver domain; Region: Response_reg; pfam00072 482957019524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957019525 active site 482957019526 phosphorylation site [posttranslational modification] 482957019527 intermolecular recognition site; other site 482957019528 dimerization interface [polypeptide binding]; other site 482957019529 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 482957019530 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957019531 dimer interface [polypeptide binding]; other site 482957019532 putative CheW interface [polypeptide binding]; other site 482957019533 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 482957019534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957019535 dimerization interface [polypeptide binding]; other site 482957019536 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 482957019537 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 482957019538 putative binding surface; other site 482957019539 active site 482957019540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957019541 ATP binding site [chemical binding]; other site 482957019542 Mg2+ binding site [ion binding]; other site 482957019543 G-X-G motif; other site 482957019544 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 482957019545 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 482957019546 Na binding site [ion binding]; other site 482957019547 Protein of unknown function, DUF485; Region: DUF485; pfam04341 482957019548 Predicted esterase [General function prediction only]; Region: COG0400 482957019549 putative hydrolase; Provisional; Region: PRK11460 482957019550 L-asparagine permease; Provisional; Region: PRK15049 482957019551 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 482957019552 Aspartase; Region: Aspartase; cd01357 482957019553 active sites [active] 482957019554 tetramer interface [polypeptide binding]; other site 482957019555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019556 transcriptional activator TtdR; Provisional; Region: PRK09801 482957019557 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957019558 putative effector binding pocket; other site 482957019559 dimerization interface [polypeptide binding]; other site 482957019560 L-asparaginase II; Region: Asparaginase_II; pfam06089 482957019561 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 482957019562 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957019563 N-terminal plug; other site 482957019564 ligand-binding site [chemical binding]; other site 482957019565 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 482957019566 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 482957019567 NAD(P) binding site [chemical binding]; other site 482957019568 catalytic residues [active] 482957019569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957019570 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957019571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957019572 DNA-binding site [nucleotide binding]; DNA binding site 482957019573 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957019574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957019575 homodimer interface [polypeptide binding]; other site 482957019576 catalytic residue [active] 482957019577 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 482957019578 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 482957019579 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957019580 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 482957019581 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957019582 PYR/PP interface [polypeptide binding]; other site 482957019583 dimer interface [polypeptide binding]; other site 482957019584 TPP binding site [chemical binding]; other site 482957019585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957019586 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 482957019587 TPP-binding site; other site 482957019588 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 482957019589 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 482957019590 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 482957019591 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 482957019592 metal ion-dependent adhesion site (MIDAS); other site 482957019593 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 482957019594 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 482957019595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 482957019596 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957019597 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 482957019598 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957019599 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 482957019600 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 482957019601 4Fe-4S binding domain; Region: Fer4; pfam00037 482957019602 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 482957019603 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 482957019604 molybdopterin cofactor binding site; other site 482957019605 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 482957019606 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 482957019607 putative molybdopterin cofactor binding site; other site 482957019608 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 482957019609 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957019610 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957019611 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957019612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019613 choline dehydrogenase; Validated; Region: PRK02106 482957019614 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 482957019615 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957019616 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957019617 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 482957019618 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957019619 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957019620 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957019621 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957019622 dimerization interface [polypeptide binding]; other site 482957019623 putative DNA binding site [nucleotide binding]; other site 482957019624 putative Zn2+ binding site [ion binding]; other site 482957019625 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 482957019626 putative hydrophobic ligand binding site [chemical binding]; other site 482957019627 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 482957019628 Predicted membrane protein [Function unknown]; Region: COG3817 482957019629 Protein of unknown function (DUF979); Region: DUF979; pfam06166 482957019630 Protein of unknown function (DUF969); Region: DUF969; pfam06149 482957019631 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 482957019632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957019633 active site 482957019634 phosphorylation site [posttranslational modification] 482957019635 intermolecular recognition site; other site 482957019636 CheB methylesterase; Region: CheB_methylest; pfam01339 482957019637 Response regulator receiver domain; Region: Response_reg; pfam00072 482957019638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957019639 active site 482957019640 phosphorylation site [posttranslational modification] 482957019641 intermolecular recognition site; other site 482957019642 dimerization interface [polypeptide binding]; other site 482957019643 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957019644 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957019645 metal binding site [ion binding]; metal-binding site 482957019646 active site 482957019647 I-site; other site 482957019648 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 482957019649 GAF domain; Region: GAF; pfam01590 482957019650 PAS fold; Region: PAS; pfam00989 482957019651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957019652 putative active site [active] 482957019653 heme pocket [chemical binding]; other site 482957019654 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957019655 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957019656 metal binding site [ion binding]; metal-binding site 482957019657 active site 482957019658 I-site; other site 482957019659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957019660 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 482957019661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019662 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957019663 dimerization interface [polypeptide binding]; other site 482957019664 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 482957019665 Sulfatase; Region: Sulfatase; cl17466 482957019666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957019667 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957019668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957019669 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 482957019670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957019671 active site 482957019672 motif I; other site 482957019673 motif II; other site 482957019674 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 482957019675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957019678 dimerization interface [polypeptide binding]; other site 482957019679 shikimate transporter; Provisional; Region: PRK09952 482957019680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019681 putative substrate translocation pore; other site 482957019682 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 482957019683 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 482957019684 tetrameric interface [polypeptide binding]; other site 482957019685 NAD binding site [chemical binding]; other site 482957019686 catalytic residues [active] 482957019687 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957019688 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 482957019689 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 482957019690 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 482957019691 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 482957019692 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 482957019693 Na binding site [ion binding]; other site 482957019694 putative substrate binding site [chemical binding]; other site 482957019695 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 482957019696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019698 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 482957019699 putative substrate binding pocket [chemical binding]; other site 482957019700 putative dimerization interface [polypeptide binding]; other site 482957019701 Predicted permeases [General function prediction only]; Region: COG0679 482957019702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019703 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957019704 putative substrate translocation pore; other site 482957019705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019707 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957019708 dimerization interface [polypeptide binding]; other site 482957019709 substrate binding pocket [chemical binding]; other site 482957019710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 482957019711 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 482957019712 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 482957019713 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 482957019714 Ligand binding site; other site 482957019715 Putative Catalytic site; other site 482957019716 DXD motif; other site 482957019717 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 482957019718 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 482957019719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957019720 binding surface 482957019721 Tetratricopeptide repeat; Region: TPR_16; pfam13432 482957019722 TPR motif; other site 482957019723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957019724 binding surface 482957019725 Tetratricopeptide repeat; Region: TPR_16; pfam13432 482957019726 TPR motif; other site 482957019727 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 482957019728 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957019729 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 482957019730 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 482957019731 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 482957019732 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 482957019733 ATP binding site [chemical binding]; other site 482957019734 Walker A motif; other site 482957019735 hexamer interface [polypeptide binding]; other site 482957019736 Walker B motif; other site 482957019737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 482957019738 active site 482957019739 phosphorylation site [posttranslational modification] 482957019740 intermolecular recognition site; other site 482957019741 dimerization interface [polypeptide binding]; other site 482957019742 AAA domain; Region: AAA_31; pfam13614 482957019743 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 482957019744 Type IV pili component [Cell motility and secretion]; Region: COG5461 482957019745 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 482957019746 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 482957019747 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 482957019748 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 482957019749 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 482957019750 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 482957019751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 482957019752 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957019753 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957019754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957019755 dimer interface [polypeptide binding]; other site 482957019756 conserved gate region; other site 482957019757 ABC-ATPase subunit interface; other site 482957019758 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957019759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957019760 dimer interface [polypeptide binding]; other site 482957019761 putative PBP binding loops; other site 482957019762 ABC-ATPase subunit interface; other site 482957019763 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 482957019764 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 482957019765 Walker A/P-loop; other site 482957019766 ATP binding site [chemical binding]; other site 482957019767 Q-loop/lid; other site 482957019768 ABC transporter signature motif; other site 482957019769 Walker B; other site 482957019770 D-loop; other site 482957019771 H-loop/switch region; other site 482957019772 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 482957019773 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 482957019774 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 482957019775 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 482957019776 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 482957019777 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 482957019778 peptide binding site [polypeptide binding]; other site 482957019779 Domain of unknown function (DUF427); Region: DUF427; cl00998 482957019780 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957019781 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957019782 substrate binding pocket [chemical binding]; other site 482957019783 membrane-bound complex binding site; other site 482957019784 hinge residues; other site 482957019785 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 482957019786 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019788 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957019789 putative effector binding pocket; other site 482957019790 dimerization interface [polypeptide binding]; other site 482957019791 possible frameshift; hypothetical protein 482957019792 possible frameshift; hypothetical protein 482957019793 arginine decarboxylase; Provisional; Region: PRK15029 482957019794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957019795 active site 482957019796 phosphorylation site [posttranslational modification] 482957019797 intermolecular recognition site; other site 482957019798 dimerization interface [polypeptide binding]; other site 482957019799 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 482957019800 homodimer interface [polypeptide binding]; other site 482957019801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957019802 catalytic residue [active] 482957019803 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 482957019804 ornithine decarboxylase; Provisional; Region: PRK13578 482957019805 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 482957019806 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 482957019807 homodimer interface [polypeptide binding]; other site 482957019808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957019809 catalytic residue [active] 482957019810 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 482957019811 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957019812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019813 putative substrate translocation pore; other site 482957019814 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 482957019815 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 482957019816 putative active site [active] 482957019817 metal binding site [ion binding]; metal-binding site 482957019818 Uncharacterized conserved protein [Function unknown]; Region: COG1359 482957019819 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 482957019820 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 482957019821 FAD binding domain; Region: FAD_binding_4; pfam01565 482957019822 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 482957019823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957019824 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 482957019825 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 482957019826 nucleotide binding site [chemical binding]; other site 482957019827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019828 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957019829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957019830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957019831 C factor cell-cell signaling protein; Provisional; Region: PRK09009 482957019832 NAD(P) binding site [chemical binding]; other site 482957019833 active site 482957019834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019836 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 482957019837 putative substrate binding pocket [chemical binding]; other site 482957019838 putative dimerization interface [polypeptide binding]; other site 482957019839 classical (c) SDRs; Region: SDR_c; cd05233 482957019840 NAD(P) binding site [chemical binding]; other site 482957019841 active site 482957019842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957019843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957019844 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957019845 putative effector binding pocket; other site 482957019846 dimerization interface [polypeptide binding]; other site 482957019847 xanthine permease; Region: pbuX; TIGR03173 482957019848 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 482957019849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957019850 NAD(P) binding site [chemical binding]; other site 482957019851 active site 482957019852 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 482957019853 nudix motif; other site 482957019854 Response regulator receiver domain; Region: Response_reg; pfam00072 482957019855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957019856 active site 482957019857 phosphorylation site [posttranslational modification] 482957019858 intermolecular recognition site; other site 482957019859 dimerization interface [polypeptide binding]; other site 482957019860 Heme NO binding associated; Region: HNOBA; pfam07701 482957019861 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 482957019862 cyclase homology domain; Region: CHD; cd07302 482957019863 nucleotidyl binding site; other site 482957019864 metal binding site [ion binding]; metal-binding site 482957019865 dimer interface [polypeptide binding]; other site 482957019866 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957019867 PAS domain; Region: PAS_9; pfam13426 482957019868 putative active site [active] 482957019869 heme pocket [chemical binding]; other site 482957019870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957019871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957019872 dimer interface [polypeptide binding]; other site 482957019873 phosphorylation site [posttranslational modification] 482957019874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957019875 ATP binding site [chemical binding]; other site 482957019876 Mg2+ binding site [ion binding]; other site 482957019877 G-X-G motif; other site 482957019878 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 482957019879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957019880 active site 482957019881 phosphorylation site [posttranslational modification] 482957019882 intermolecular recognition site; other site 482957019883 dimerization interface [polypeptide binding]; other site 482957019884 Fic family protein [Function unknown]; Region: COG3177 482957019885 Fic/DOC family; Region: Fic; pfam02661 482957019886 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 482957019887 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 482957019888 G1 box; other site 482957019889 putative GEF interaction site [polypeptide binding]; other site 482957019890 GTP/Mg2+ binding site [chemical binding]; other site 482957019891 Switch I region; other site 482957019892 G2 box; other site 482957019893 G3 box; other site 482957019894 Switch II region; other site 482957019895 G4 box; other site 482957019896 G5 box; other site 482957019897 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 482957019898 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 482957019899 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 482957019900 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 482957019901 selenocysteine synthase; Provisional; Region: PRK04311 482957019902 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 482957019903 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 482957019904 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957019905 catalytic residue [active] 482957019906 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 482957019907 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 482957019908 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 482957019909 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 482957019910 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 482957019911 4Fe-4S binding domain; Region: Fer4; cl02805 482957019912 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 482957019913 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 482957019914 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 482957019915 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 482957019916 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 482957019917 molybdopterin cofactor binding site; other site 482957019918 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 482957019919 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 482957019920 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957019921 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957019922 trimer interface [polypeptide binding]; other site 482957019923 eyelet of channel; other site 482957019924 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 482957019925 dimer interface [polypeptide binding]; other site 482957019926 aminoglycoside resistance protein; Provisional; Region: PRK13746 482957019927 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 482957019928 active site 482957019929 NTP binding site [chemical binding]; other site 482957019930 metal binding triad [ion binding]; metal-binding site 482957019931 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 482957019932 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 482957019933 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 482957019934 active site 482957019935 tetramer interface; other site 482957019936 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 482957019937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957019938 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 482957019939 putative ADP-binding pocket [chemical binding]; other site 482957019940 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 482957019941 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 482957019942 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 482957019943 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 482957019944 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 482957019945 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 482957019946 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 482957019947 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 482957019948 NADP-binding site; other site 482957019949 homotetramer interface [polypeptide binding]; other site 482957019950 substrate binding site [chemical binding]; other site 482957019951 homodimer interface [polypeptide binding]; other site 482957019952 active site 482957019953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957019954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957019955 NAD(P) binding site [chemical binding]; other site 482957019956 active site 482957019957 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 482957019958 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 482957019959 homodimer interface [polypeptide binding]; other site 482957019960 substrate-cofactor binding pocket; other site 482957019961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957019962 catalytic residue [active] 482957019963 amidophosphoribosyltransferase; Provisional; Region: PRK09246 482957019964 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 482957019965 active site 482957019966 tetramer interface [polypeptide binding]; other site 482957019967 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 482957019968 active site 482957019969 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 482957019970 Colicin V production protein; Region: Colicin_V; pfam02674 482957019971 Sporulation related domain; Region: SPOR; cl10051 482957019972 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 482957019973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 482957019974 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 482957019975 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 482957019976 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 482957019977 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 482957019978 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 482957019979 substrate binding site [chemical binding]; other site 482957019980 active site 482957019981 catalytic residues [active] 482957019982 heterodimer interface [polypeptide binding]; other site 482957019983 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 482957019984 DNA methylase; Region: N6_N4_Mtase; pfam01555 482957019985 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 482957019986 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 482957019987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957019988 catalytic residue [active] 482957019989 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 482957019990 active site 482957019991 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 482957019992 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 482957019993 dimerization interface 3.5A [polypeptide binding]; other site 482957019994 active site 482957019995 FimV N-terminal domain; Region: FimV_core; TIGR03505 482957019996 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 482957019997 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 482957019998 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 482957019999 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 482957020000 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 482957020001 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 482957020002 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 482957020003 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 482957020004 tartrate dehydrogenase; Region: TTC; TIGR02089 482957020005 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 482957020006 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 482957020007 substrate binding site [chemical binding]; other site 482957020008 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 482957020009 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 482957020010 substrate binding site [chemical binding]; other site 482957020011 ligand binding site [chemical binding]; other site 482957020012 Cupin domain; Region: Cupin_2; cl17218 482957020013 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 482957020014 GSH binding site (G-site) [chemical binding]; other site 482957020015 C-terminal domain interface [polypeptide binding]; other site 482957020016 dimer interface [polypeptide binding]; other site 482957020017 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 482957020018 dimer interface [polypeptide binding]; other site 482957020019 N-terminal domain interface [polypeptide binding]; other site 482957020020 substrate binding pocket (H-site) [chemical binding]; other site 482957020021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 482957020022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020023 putative substrate translocation pore; other site 482957020024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020025 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957020026 putative effector binding pocket; other site 482957020027 dimerization interface [polypeptide binding]; other site 482957020028 lysine transporter; Provisional; Region: PRK10836 482957020029 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957020030 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 482957020031 AsnC family; Region: AsnC_trans_reg; pfam01037 482957020032 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 482957020033 Amidinotransferase; Region: Amidinotransf; cl12043 482957020034 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 482957020035 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 482957020036 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957020037 Cupin domain; Region: Cupin_2; cl17218 482957020038 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957020039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020040 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 482957020041 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 482957020042 dimer interface [polypeptide binding]; other site 482957020043 active site 482957020044 citrylCoA binding site [chemical binding]; other site 482957020045 NADH binding [chemical binding]; other site 482957020046 cationic pore residues; other site 482957020047 oxalacetate/citrate binding site [chemical binding]; other site 482957020048 coenzyme A binding site [chemical binding]; other site 482957020049 catalytic triad [active] 482957020050 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 482957020051 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 482957020052 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 482957020053 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 482957020054 L-aspartate oxidase; Provisional; Region: PRK06175 482957020055 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 482957020056 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 482957020057 SdhC subunit interface [polypeptide binding]; other site 482957020058 proximal heme binding site [chemical binding]; other site 482957020059 cardiolipin binding site; other site 482957020060 Iron-sulfur protein interface; other site 482957020061 proximal quinone binding site [chemical binding]; other site 482957020062 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 482957020063 Iron-sulfur protein interface; other site 482957020064 proximal quinone binding site [chemical binding]; other site 482957020065 SdhD (CybS) interface [polypeptide binding]; other site 482957020066 proximal heme binding site [chemical binding]; other site 482957020067 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 482957020068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957020069 DNA-binding site [nucleotide binding]; DNA binding site 482957020070 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 482957020071 malate dehydrogenase; Provisional; Region: PRK05442 482957020072 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 482957020073 NAD(P) binding site [chemical binding]; other site 482957020074 dimer interface [polypeptide binding]; other site 482957020075 malate binding site [chemical binding]; other site 482957020076 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 482957020077 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 482957020078 2-methylcitrate dehydratase; Region: prpD; TIGR02330 482957020079 aconitate hydratase; Provisional; Region: acnA; PRK12881 482957020080 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 482957020081 substrate binding site [chemical binding]; other site 482957020082 ligand binding site [chemical binding]; other site 482957020083 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 482957020084 substrate binding site [chemical binding]; other site 482957020085 Domain of unknown function (DU1801); Region: DUF1801; cl17490 482957020086 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 482957020087 putative hydrophobic ligand binding site [chemical binding]; other site 482957020088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957020089 dimerization interface [polypeptide binding]; other site 482957020090 putative DNA binding site [nucleotide binding]; other site 482957020091 putative Zn2+ binding site [ion binding]; other site 482957020092 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 482957020093 peptidase domain interface [polypeptide binding]; other site 482957020094 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 482957020095 active site 482957020096 catalytic triad [active] 482957020097 calcium binding site [ion binding]; other site 482957020098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957020099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020100 putative substrate translocation pore; other site 482957020101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020102 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020104 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 482957020105 substrate binding pocket [chemical binding]; other site 482957020106 dimerization interface [polypeptide binding]; other site 482957020107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957020109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020110 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957020111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957020112 dimer interface [polypeptide binding]; other site 482957020113 conserved gate region; other site 482957020114 putative PBP binding loops; other site 482957020115 ABC-ATPase subunit interface; other site 482957020116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957020117 dimer interface [polypeptide binding]; other site 482957020118 conserved gate region; other site 482957020119 putative PBP binding loops; other site 482957020120 ABC-ATPase subunit interface; other site 482957020121 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 482957020122 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 482957020123 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 482957020124 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 482957020125 Walker A/P-loop; other site 482957020126 ATP binding site [chemical binding]; other site 482957020127 Q-loop/lid; other site 482957020128 ABC transporter signature motif; other site 482957020129 Walker B; other site 482957020130 D-loop; other site 482957020131 H-loop/switch region; other site 482957020132 TOBE domain; Region: TOBE_2; pfam08402 482957020133 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957020134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957020135 DNA-binding site [nucleotide binding]; DNA binding site 482957020136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957020137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957020138 homodimer interface [polypeptide binding]; other site 482957020139 catalytic residue [active] 482957020140 lipase chaperone; Provisional; Region: PRK01294 482957020141 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 482957020142 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 482957020143 Lipase (class 2); Region: Lipase_2; pfam01674 482957020144 PGAP1-like protein; Region: PGAP1; pfam07819 482957020145 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 482957020146 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957020147 N-terminal plug; other site 482957020148 ligand-binding site [chemical binding]; other site 482957020149 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 482957020150 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 482957020151 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 482957020152 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 482957020153 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 482957020154 E3 interaction surface; other site 482957020155 lipoyl attachment site [posttranslational modification]; other site 482957020156 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957020157 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 482957020158 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 482957020159 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 482957020160 Methyltransferase domain; Region: Methyltransf_23; pfam13489 482957020161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957020162 S-adenosylmethionine binding site [chemical binding]; other site 482957020163 NAD-dependent deacetylase; Provisional; Region: PRK05333 482957020164 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 482957020165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957020166 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 482957020167 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 482957020168 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 482957020169 putative mechanosensitive channel protein; Provisional; Region: PRK11465 482957020170 Mechanosensitive ion channel; Region: MS_channel; pfam00924 482957020171 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 482957020172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957020173 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 482957020174 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 482957020175 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957020176 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957020177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957020178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020179 putative substrate translocation pore; other site 482957020180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020181 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 482957020182 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 482957020183 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 482957020184 tetramer interface [polypeptide binding]; other site 482957020185 heme binding pocket [chemical binding]; other site 482957020186 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957020187 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 482957020188 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957020189 VirK protein; Region: VirK; pfam06903 482957020190 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 482957020191 Phosphotransferase enzyme family; Region: APH; pfam01636 482957020192 active site 482957020193 ATP binding site [chemical binding]; other site 482957020194 antibiotic binding site [chemical binding]; other site 482957020195 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 482957020196 peptidase domain interface [polypeptide binding]; other site 482957020197 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 482957020198 active site 482957020199 catalytic triad [active] 482957020200 calcium binding site [ion binding]; other site 482957020201 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 482957020202 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 482957020203 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957020204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957020205 DNA-binding site [nucleotide binding]; DNA binding site 482957020206 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957020207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957020208 homodimer interface [polypeptide binding]; other site 482957020209 catalytic residue [active] 482957020210 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 482957020211 putative active site [active] 482957020212 catalytic site [active] 482957020213 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 482957020214 PLD-like domain; Region: PLDc_2; pfam13091 482957020215 putative active site [active] 482957020216 catalytic site [active] 482957020217 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 482957020218 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 482957020219 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 482957020220 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 482957020221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957020222 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 482957020223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 482957020224 DNA binding residues [nucleotide binding] 482957020225 DNA primase; Validated; Region: dnaG; PRK05667 482957020226 CHC2 zinc finger; Region: zf-CHC2; pfam01807 482957020227 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 482957020228 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 482957020229 active site 482957020230 metal binding site [ion binding]; metal-binding site 482957020231 interdomain interaction site; other site 482957020232 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 482957020233 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 482957020234 Yqey-like protein; Region: YqeY; pfam09424 482957020235 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 482957020236 Predicted flavoproteins [General function prediction only]; Region: COG2081 482957020237 UGMP family protein; Validated; Region: PRK09604 482957020238 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 482957020239 putative GTP cyclohydrolase; Provisional; Region: PRK13674 482957020240 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 482957020241 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 482957020242 TPP-binding site; other site 482957020243 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 482957020244 PYR/PP interface [polypeptide binding]; other site 482957020245 dimer interface [polypeptide binding]; other site 482957020246 TPP binding site [chemical binding]; other site 482957020247 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 482957020248 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 482957020249 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 482957020250 substrate binding pocket [chemical binding]; other site 482957020251 chain length determination region; other site 482957020252 substrate-Mg2+ binding site; other site 482957020253 catalytic residues [active] 482957020254 aspartate-rich region 1; other site 482957020255 active site lid residues [active] 482957020256 aspartate-rich region 2; other site 482957020257 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 482957020258 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957020259 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957020260 [2Fe-2S] cluster binding site [ion binding]; other site 482957020261 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 482957020262 alpha subunit interface [polypeptide binding]; other site 482957020263 active site 482957020264 substrate binding site [chemical binding]; other site 482957020265 Fe binding site [ion binding]; other site 482957020266 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 482957020267 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 482957020268 active site residue [active] 482957020269 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 482957020270 active site residue [active] 482957020271 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 482957020272 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 482957020273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957020274 DNA polymerase I; Provisional; Region: PRK05755 482957020275 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 482957020276 active site 482957020277 metal binding site 1 [ion binding]; metal-binding site 482957020278 putative 5' ssDNA interaction site; other site 482957020279 metal binding site 3; metal-binding site 482957020280 metal binding site 2 [ion binding]; metal-binding site 482957020281 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 482957020282 putative DNA binding site [nucleotide binding]; other site 482957020283 putative metal binding site [ion binding]; other site 482957020284 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 482957020285 active site 482957020286 catalytic site [active] 482957020287 substrate binding site [chemical binding]; other site 482957020288 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 482957020289 active site 482957020290 DNA binding site [nucleotide binding] 482957020291 catalytic site [active] 482957020292 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 482957020293 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 482957020294 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957020295 conserved cys residue [active] 482957020296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020298 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 482957020299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020301 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957020302 putative effector binding pocket; other site 482957020303 dimerization interface [polypeptide binding]; other site 482957020304 Cupin domain; Region: Cupin_2; pfam07883 482957020305 classical (c) SDRs; Region: SDR_c; cd05233 482957020306 NAD(P) binding site [chemical binding]; other site 482957020307 active site 482957020308 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957020309 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957020310 active site 482957020311 catalytic tetrad [active] 482957020312 AMP nucleosidase; Provisional; Region: PRK08292 482957020313 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 482957020314 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 482957020315 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 482957020316 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 482957020317 putative active site [active] 482957020318 putative substrate binding site [chemical binding]; other site 482957020319 ATP binding site [chemical binding]; other site 482957020320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957020321 MarR family; Region: MarR; pfam01047 482957020322 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 482957020323 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 482957020324 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 482957020325 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 482957020326 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 482957020327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957020328 dimer interface [polypeptide binding]; other site 482957020329 conserved gate region; other site 482957020330 putative PBP binding loops; other site 482957020331 ABC-ATPase subunit interface; other site 482957020332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957020333 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 482957020334 Walker A/P-loop; other site 482957020335 ATP binding site [chemical binding]; other site 482957020336 Q-loop/lid; other site 482957020337 ABC transporter signature motif; other site 482957020338 Walker B; other site 482957020339 D-loop; other site 482957020340 H-loop/switch region; other site 482957020341 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 482957020342 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 482957020343 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 482957020344 molybdenum-pterin binding domain; Region: Mop; TIGR00638 482957020345 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 482957020346 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 482957020347 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 482957020348 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957020350 dimerization interface [polypeptide binding]; other site 482957020351 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 482957020352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957020353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957020354 dimer interface [polypeptide binding]; other site 482957020355 phosphorylation site [posttranslational modification] 482957020356 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 482957020357 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 482957020358 Domain of unknown function DUF21; Region: DUF21; pfam01595 482957020359 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 482957020360 Transporter associated domain; Region: CorC_HlyC; smart01091 482957020361 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 482957020362 thiamine phosphate binding site [chemical binding]; other site 482957020363 active site 482957020364 pyrophosphate binding site [ion binding]; other site 482957020365 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 482957020366 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 482957020367 active site 482957020368 catalytic site [active] 482957020369 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 482957020370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957020371 S-adenosylmethionine binding site [chemical binding]; other site 482957020372 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957020373 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 482957020374 putative C-terminal domain interface [polypeptide binding]; other site 482957020375 putative GSH binding site (G-site) [chemical binding]; other site 482957020376 putative dimer interface [polypeptide binding]; other site 482957020377 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 482957020378 putative N-terminal domain interface [polypeptide binding]; other site 482957020379 putative dimer interface [polypeptide binding]; other site 482957020380 putative substrate binding pocket (H-site) [chemical binding]; other site 482957020381 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 482957020382 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 482957020383 active site 482957020384 metal binding site [ion binding]; metal-binding site 482957020385 RES domain; Region: RES; smart00953 482957020386 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 482957020387 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 482957020388 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957020389 substrate binding pocket [chemical binding]; other site 482957020390 membrane-bound complex binding site; other site 482957020391 hinge residues; other site 482957020392 Predicted membrane protein [Function unknown]; Region: COG2246 482957020393 GtrA-like protein; Region: GtrA; pfam04138 482957020394 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 482957020395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957020396 Walker A motif; other site 482957020397 ATP binding site [chemical binding]; other site 482957020398 Walker B motif; other site 482957020399 arginine finger; other site 482957020400 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957020401 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 482957020402 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 482957020403 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 482957020404 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 482957020405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020406 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957020407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020409 putative substrate translocation pore; other site 482957020410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020411 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957020412 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 482957020413 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957020414 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 482957020415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957020416 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 482957020417 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 482957020418 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957020419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 482957020420 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 482957020421 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 482957020422 DXD motif; other site 482957020423 tyrosine kinase; Provisional; Region: PRK11519 482957020424 Chain length determinant protein; Region: Wzz; pfam02706 482957020425 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 482957020426 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 482957020427 P-loop; other site 482957020428 Magnesium ion binding site [ion binding]; other site 482957020429 polysaccharide export protein Wza; Provisional; Region: PRK15078 482957020430 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 482957020431 SLBB domain; Region: SLBB; pfam10531 482957020432 SLBB domain; Region: SLBB; pfam10531 482957020433 Low molecular weight phosphatase family; Region: LMWPc; cd00115 482957020434 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 482957020435 active site 482957020436 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 482957020437 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 482957020438 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 482957020439 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 482957020440 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 482957020441 Bacterial sugar transferase; Region: Bac_transf; pfam02397 482957020442 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 482957020443 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 482957020444 Substrate binding site; other site 482957020445 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 482957020446 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 482957020447 Transcriptional activator HlyU; Region: HlyU; cl02273 482957020448 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 482957020449 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 482957020450 Rubrerythrin [Energy production and conversion]; Region: COG1592 482957020451 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 482957020452 binuclear metal center [ion binding]; other site 482957020453 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 482957020454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 482957020455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957020456 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 482957020457 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 482957020458 YCII-related domain; Region: YCII; cl00999 482957020459 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 482957020460 generic binding surface I; other site 482957020461 generic binding surface II; other site 482957020462 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 482957020463 putative active site [active] 482957020464 putative catalytic site [active] 482957020465 putative Mg binding site IVb [ion binding]; other site 482957020466 putative DNA binding site [nucleotide binding]; other site 482957020467 putative phosphate binding site [ion binding]; other site 482957020468 putative Mg binding site IVa [ion binding]; other site 482957020469 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 482957020470 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 482957020471 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 482957020472 Domain of unknown function DUF20; Region: UPF0118; pfam01594 482957020473 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 482957020474 Prostaglandin dehydrogenases; Region: PGDH; cd05288 482957020475 NAD(P) binding site [chemical binding]; other site 482957020476 substrate binding site [chemical binding]; other site 482957020477 dimer interface [polypeptide binding]; other site 482957020478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957020479 short chain dehydrogenase; Validated; Region: PRK07069 482957020480 NAD(P) binding site [chemical binding]; other site 482957020481 active site 482957020482 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 482957020483 manganese transport protein MntH; Reviewed; Region: PRK00701 482957020484 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 482957020485 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957020486 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020487 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020488 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 482957020489 substrate binding pocket [chemical binding]; other site 482957020490 dimerization interface [polypeptide binding]; other site 482957020491 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 482957020492 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 482957020493 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 482957020494 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 482957020495 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 482957020496 Walker A/P-loop; other site 482957020497 ATP binding site [chemical binding]; other site 482957020498 Q-loop/lid; other site 482957020499 ABC transporter signature motif; other site 482957020500 Walker B; other site 482957020501 D-loop; other site 482957020502 H-loop/switch region; other site 482957020503 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 482957020504 Lumazine binding domain; Region: Lum_binding; pfam00677 482957020505 Lumazine binding domain; Region: Lum_binding; pfam00677 482957020506 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 482957020507 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 482957020508 putative Cl- selectivity filter; other site 482957020509 putative pore gating glutamate residue; other site 482957020510 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 482957020511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957020512 active site 482957020513 phosphorylation site [posttranslational modification] 482957020514 intermolecular recognition site; other site 482957020515 dimerization interface [polypeptide binding]; other site 482957020516 CheB methylesterase; Region: CheB_methylest; pfam01339 482957020517 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 482957020518 putative binding surface; other site 482957020519 active site 482957020520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957020521 ATP binding site [chemical binding]; other site 482957020522 Mg2+ binding site [ion binding]; other site 482957020523 G-X-G motif; other site 482957020524 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 482957020525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957020526 Response regulator receiver domain; Region: Response_reg; pfam00072 482957020527 active site 482957020528 phosphorylation site [posttranslational modification] 482957020529 intermolecular recognition site; other site 482957020530 dimerization interface [polypeptide binding]; other site 482957020531 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 482957020532 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 482957020533 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 482957020534 Tetratricopeptide repeat; Region: TPR_16; pfam13432 482957020535 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 482957020536 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 482957020537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957020538 dimerization interface [polypeptide binding]; other site 482957020539 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 482957020540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957020541 dimer interface [polypeptide binding]; other site 482957020542 putative CheW interface [polypeptide binding]; other site 482957020543 Response regulator receiver domain; Region: Response_reg; pfam00072 482957020544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957020545 active site 482957020546 phosphorylation site [posttranslational modification] 482957020547 intermolecular recognition site; other site 482957020548 dimerization interface [polypeptide binding]; other site 482957020549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 482957020550 dimer interface [polypeptide binding]; other site 482957020551 phosphorylation site [posttranslational modification] 482957020552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957020553 Mg2+ binding site [ion binding]; other site 482957020554 G-X-G motif; other site 482957020555 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 482957020556 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 482957020557 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 482957020558 NAD(P) binding site [chemical binding]; other site 482957020559 catalytic residues [active] 482957020560 acetolactate synthase; Reviewed; Region: PRK08322 482957020561 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 482957020562 PYR/PP interface [polypeptide binding]; other site 482957020563 dimer interface [polypeptide binding]; other site 482957020564 TPP binding site [chemical binding]; other site 482957020565 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957020566 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 482957020567 TPP-binding site [chemical binding]; other site 482957020568 dimer interface [polypeptide binding]; other site 482957020569 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 482957020570 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 482957020571 Protein of unknown function (DUF445); Region: DUF445; pfam04286 482957020572 Transcriptional regulator [Transcription]; Region: IclR; COG1414 482957020573 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 482957020574 Bacterial transcriptional regulator; Region: IclR; pfam01614 482957020575 OPT oligopeptide transporter protein; Region: OPT; cl14607 482957020576 OPT oligopeptide transporter protein; Region: OPT; cl14607 482957020577 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 482957020578 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957020579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957020580 catalytic residue [active] 482957020581 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 482957020582 active site pocket [active] 482957020583 oxyanion hole [active] 482957020584 catalytic triad [active] 482957020585 active site nucleophile [active] 482957020586 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957020587 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957020588 trimer interface [polypeptide binding]; other site 482957020589 eyelet of channel; other site 482957020590 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 482957020591 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 482957020592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957020593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957020594 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 482957020595 [2Fe-2S] cluster binding site [ion binding]; other site 482957020596 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 482957020597 inter-subunit interface; other site 482957020598 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 482957020599 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 482957020600 putative alpha subunit interface [polypeptide binding]; other site 482957020601 putative active site [active] 482957020602 putative substrate binding site [chemical binding]; other site 482957020603 Fe binding site [ion binding]; other site 482957020604 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957020605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020606 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 482957020607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020608 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 482957020609 dimerizarion interface [polypeptide binding]; other site 482957020610 CrgA pocket; other site 482957020611 substrate binding pocket [chemical binding]; other site 482957020612 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 482957020613 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 482957020614 octamer interface [polypeptide binding]; other site 482957020615 active site 482957020616 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 482957020617 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 482957020618 dimer interface [polypeptide binding]; other site 482957020619 active site 482957020620 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 482957020621 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 482957020622 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957020623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020625 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 482957020626 putative substrate binding pocket [chemical binding]; other site 482957020627 putative dimerization interface [polypeptide binding]; other site 482957020628 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 482957020629 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957020630 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 482957020631 active site 482957020632 FMN binding site [chemical binding]; other site 482957020633 2,4-decadienoyl-CoA binding site; other site 482957020634 catalytic residue [active] 482957020635 4Fe-4S cluster binding site [ion binding]; other site 482957020636 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 482957020637 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957020638 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957020639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020642 LysR substrate binding domain; Region: LysR_substrate; pfam03466 482957020643 dimerization interface [polypeptide binding]; other site 482957020644 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 482957020645 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 482957020646 substrate binding site [chemical binding]; other site 482957020647 Protein of unknown function (DUF521); Region: DUF521; pfam04412 482957020648 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 482957020649 substrate binding site [chemical binding]; other site 482957020650 ligand binding site [chemical binding]; other site 482957020651 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957020652 MarR family; Region: MarR_2; pfam12802 482957020653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020655 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957020656 putative effector binding pocket; other site 482957020657 dimerization interface [polypeptide binding]; other site 482957020658 Transcriptional regulators [Transcription]; Region: MarR; COG1846 482957020659 MarR family; Region: MarR_2; pfam12802 482957020660 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 482957020661 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957020662 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957020663 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 482957020664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020665 putative substrate translocation pore; other site 482957020666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020667 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 482957020668 LysE type translocator; Region: LysE; cl00565 482957020669 glutathione S-transferase; Provisional; Region: PRK15113 482957020670 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 482957020671 C-terminal domain interface [polypeptide binding]; other site 482957020672 GSH binding site (G-site) [chemical binding]; other site 482957020673 dimer interface [polypeptide binding]; other site 482957020674 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 482957020675 putative dimer interface [polypeptide binding]; other site 482957020676 N-terminal domain interface [polypeptide binding]; other site 482957020677 putative substrate binding pocket (H-site) [chemical binding]; other site 482957020678 TIGR02594 family protein; Region: TIGR02594 482957020679 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957020680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020681 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957020682 dimerization interface [polypeptide binding]; other site 482957020683 substrate binding pocket [chemical binding]; other site 482957020684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020685 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957020686 putative substrate translocation pore; other site 482957020687 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957020688 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 482957020689 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 482957020690 active site 482957020691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957020692 dimerization interface [polypeptide binding]; other site 482957020693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 482957020694 dimer interface [polypeptide binding]; other site 482957020695 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 482957020696 putative CheW interface [polypeptide binding]; other site 482957020697 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 482957020698 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 482957020699 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957020700 ligand binding site [chemical binding]; other site 482957020701 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 482957020702 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957020703 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 482957020704 ligand binding site [chemical binding]; other site 482957020705 flexible hinge region; other site 482957020706 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 482957020707 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 482957020708 N-acetyl-D-glucosamine binding site [chemical binding]; other site 482957020709 catalytic residue [active] 482957020710 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 482957020711 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957020712 putative C-terminal domain interface [polypeptide binding]; other site 482957020713 putative GSH binding site (G-site) [chemical binding]; other site 482957020714 putative dimer interface [polypeptide binding]; other site 482957020715 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 482957020716 putative N-terminal domain interface [polypeptide binding]; other site 482957020717 putative dimer interface [polypeptide binding]; other site 482957020718 putative substrate binding pocket (H-site) [chemical binding]; other site 482957020719 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 482957020720 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 482957020721 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 482957020722 Cupin domain; Region: Cupin_2; cl17218 482957020723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957020724 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957020725 TM-ABC transporter signature motif; other site 482957020726 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957020727 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 482957020728 TM-ABC transporter signature motif; other site 482957020729 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 482957020730 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 482957020731 Walker A/P-loop; other site 482957020732 ATP binding site [chemical binding]; other site 482957020733 Q-loop/lid; other site 482957020734 ABC transporter signature motif; other site 482957020735 Walker B; other site 482957020736 D-loop; other site 482957020737 H-loop/switch region; other site 482957020738 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 482957020739 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 482957020740 putative ligand binding site [chemical binding]; other site 482957020741 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 482957020742 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 482957020743 active site 482957020744 catalytic residues [active] 482957020745 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957020746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957020747 DNA binding site [nucleotide binding] 482957020748 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 482957020749 putative dimerization interface [polypeptide binding]; other site 482957020750 putative ligand binding site [chemical binding]; other site 482957020751 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 482957020752 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 482957020753 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 482957020754 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 482957020755 Walker A/P-loop; other site 482957020756 ATP binding site [chemical binding]; other site 482957020757 Q-loop/lid; other site 482957020758 ABC transporter signature motif; other site 482957020759 Walker B; other site 482957020760 D-loop; other site 482957020761 H-loop/switch region; other site 482957020762 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957020763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957020764 dimer interface [polypeptide binding]; other site 482957020765 conserved gate region; other site 482957020766 putative PBP binding loops; other site 482957020767 ABC-ATPase subunit interface; other site 482957020768 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 482957020769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957020770 dimer interface [polypeptide binding]; other site 482957020771 conserved gate region; other site 482957020772 putative PBP binding loops; other site 482957020773 ABC-ATPase subunit interface; other site 482957020774 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 482957020775 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957020776 substrate binding pocket [chemical binding]; other site 482957020777 membrane-bound complex binding site; other site 482957020778 hinge residues; other site 482957020779 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 482957020780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957020781 active site 482957020782 phosphorylation site [posttranslational modification] 482957020783 intermolecular recognition site; other site 482957020784 dimerization interface [polypeptide binding]; other site 482957020785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957020786 DNA binding site [nucleotide binding] 482957020787 GAF domain; Region: GAF_3; pfam13492 482957020788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957020789 dimer interface [polypeptide binding]; other site 482957020790 phosphorylation site [posttranslational modification] 482957020791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957020792 ATP binding site [chemical binding]; other site 482957020793 Mg2+ binding site [ion binding]; other site 482957020794 G-X-G motif; other site 482957020795 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 482957020796 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 482957020797 K+-transporting ATPase, c chain; Region: KdpC; cl00944 482957020798 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 482957020799 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957020800 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957020801 trimer interface [polypeptide binding]; other site 482957020802 eyelet of channel; other site 482957020803 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 482957020804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957020805 DNA-binding site [nucleotide binding]; DNA binding site 482957020806 UTRA domain; Region: UTRA; pfam07702 482957020807 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 482957020808 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 482957020809 homodimer interface [polypeptide binding]; other site 482957020810 active site 482957020811 TDP-binding site; other site 482957020812 acceptor substrate-binding pocket; other site 482957020813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957020814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957020815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957020816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957020817 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 482957020818 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 482957020819 mce related protein; Region: MCE; pfam02470 482957020820 mce related protein; Region: MCE; pfam02470 482957020821 mce related protein; Region: MCE; pfam02470 482957020822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957020823 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 482957020824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020825 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 482957020826 dimerizarion interface [polypeptide binding]; other site 482957020827 CrgA pocket; other site 482957020828 substrate binding pocket [chemical binding]; other site 482957020829 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 482957020830 lysine transporter; Provisional; Region: PRK10836 482957020831 Cache domain; Region: Cache_1; pfam02743 482957020832 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 482957020833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957020834 metal binding site [ion binding]; metal-binding site 482957020835 active site 482957020836 I-site; other site 482957020837 Predicted membrane protein [Function unknown]; Region: COG1289 482957020838 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 482957020839 argininosuccinate synthase; Validated; Region: PRK05370 482957020840 argininosuccinate synthase; Provisional; Region: PRK13820 482957020841 AAA domain; Region: AAA_17; cl17253 482957020842 Shikimate kinase; Region: SKI; pfam01202 482957020843 Alginate lyase; Region: Alginate_lyase2; pfam08787 482957020844 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020846 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957020847 putative effector binding pocket; other site 482957020848 putative dimerization interface [polypeptide binding]; other site 482957020849 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957020850 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957020851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957020852 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957020853 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 482957020854 active site 482957020855 catalytic residues [active] 482957020856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957020857 S-adenosylmethionine binding site [chemical binding]; other site 482957020858 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 482957020859 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 482957020860 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 482957020861 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 482957020862 cysteine desulfurase; Provisional; Region: PRK14012 482957020863 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 482957020864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957020865 catalytic residue [active] 482957020866 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957020867 MarR family; Region: MarR_2; pfam12802 482957020868 SnoaL-like domain; Region: SnoaL_4; pfam13577 482957020869 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 482957020870 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 482957020871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957020872 Walker A motif; other site 482957020873 ATP binding site [chemical binding]; other site 482957020874 Walker B motif; other site 482957020875 arginine finger; other site 482957020876 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 482957020877 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 482957020878 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 482957020879 hypothetical protein; Reviewed; Region: PRK09588 482957020880 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 482957020881 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 482957020882 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 482957020883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957020884 S-adenosylmethionine binding site [chemical binding]; other site 482957020885 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 482957020886 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 482957020887 homodimer interface [polypeptide binding]; other site 482957020888 substrate-cofactor binding pocket; other site 482957020889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957020890 catalytic residue [active] 482957020891 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957020892 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957020893 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957020894 trimer interface [polypeptide binding]; other site 482957020895 eyelet of channel; other site 482957020896 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957020897 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 482957020898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957020899 dimerization interface [polypeptide binding]; other site 482957020900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957020901 dimer interface [polypeptide binding]; other site 482957020902 phosphorylation site [posttranslational modification] 482957020903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957020904 ATP binding site [chemical binding]; other site 482957020905 G-X-G motif; other site 482957020906 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 482957020907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957020908 active site 482957020909 phosphorylation site [posttranslational modification] 482957020910 intermolecular recognition site; other site 482957020911 dimerization interface [polypeptide binding]; other site 482957020912 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957020913 DNA binding site [nucleotide binding] 482957020914 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 482957020915 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957020916 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 482957020917 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957020918 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 482957020919 Phosphotransferase enzyme family; Region: APH; pfam01636 482957020920 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 482957020921 active site 482957020922 ATP binding site [chemical binding]; other site 482957020923 substrate binding site [chemical binding]; other site 482957020924 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 482957020925 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957020926 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957020927 N-terminal plug; other site 482957020928 ligand-binding site [chemical binding]; other site 482957020929 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 482957020930 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 482957020931 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 482957020932 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 482957020933 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 482957020934 FAD binding pocket [chemical binding]; other site 482957020935 FAD binding motif [chemical binding]; other site 482957020936 phosphate binding motif [ion binding]; other site 482957020937 beta-alpha-beta structure motif; other site 482957020938 NAD binding pocket [chemical binding]; other site 482957020939 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957020940 catalytic loop [active] 482957020941 iron binding site [ion binding]; other site 482957020942 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 482957020943 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957020944 putative C-terminal domain interface [polypeptide binding]; other site 482957020945 putative GSH binding site (G-site) [chemical binding]; other site 482957020946 putative dimer interface [polypeptide binding]; other site 482957020947 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 482957020948 putative N-terminal domain interface [polypeptide binding]; other site 482957020949 putative dimer interface [polypeptide binding]; other site 482957020950 putative substrate binding pocket (H-site) [chemical binding]; other site 482957020951 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957020952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020953 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957020954 putative effector binding pocket; other site 482957020955 dimerization interface [polypeptide binding]; other site 482957020956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957020957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957020958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957020959 short chain dehydrogenase; Provisional; Region: PRK05650 482957020960 NAD(P) binding site [chemical binding]; other site 482957020961 active site 482957020962 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957020963 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957020964 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 482957020965 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957020966 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 482957020967 Phospholipid methyltransferase; Region: PEMT; cl17370 482957020968 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 482957020969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957020970 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957020971 Predicted flavoprotein [General function prediction only]; Region: COG0431 482957020972 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957020973 Electron transfer DM13; Region: DM13; pfam10517 482957020974 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 482957020975 hypothetical protein; Provisional; Region: PRK09040 482957020976 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957020977 ligand binding site [chemical binding]; other site 482957020978 Domain of unknown function (DUF802); Region: DUF802; pfam05650 482957020979 Domain of unknown function (DUF802); Region: DUF802; pfam05650 482957020980 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 482957020981 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 482957020982 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957020983 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957020984 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957020985 Coenzyme A binding pocket [chemical binding]; other site 482957020986 mercuric reductase; Validated; Region: PRK06370 482957020987 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957020988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957020989 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 482957020990 transcriptional regulator; Provisional; Region: PRK10632 482957020991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957020992 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 482957020993 putative effector binding pocket; other site 482957020994 putative dimerization interface [polypeptide binding]; other site 482957020995 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 482957020996 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957020997 putative NAD(P) binding site [chemical binding]; other site 482957020998 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 482957020999 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957021000 putative NAD(P) binding site [chemical binding]; other site 482957021001 Helix-turn-helix domain; Region: HTH_31; pfam13560 482957021002 putative cyanate transporter; Provisional; Region: cynX; PRK09705 482957021003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021004 putative substrate translocation pore; other site 482957021005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957021006 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 482957021007 substrate binding pocket [chemical binding]; other site 482957021008 membrane-bound complex binding site; other site 482957021009 hinge residues; other site 482957021010 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 482957021011 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957021012 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 482957021013 putative acetyltransferase YhhY; Provisional; Region: PRK10140 482957021014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957021015 Coenzyme A binding pocket [chemical binding]; other site 482957021016 C-lysozyme inhibitor; Provisional; Region: PRK09993 482957021017 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 482957021018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957021019 active site 482957021020 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 482957021021 Na binding site [ion binding]; other site 482957021022 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 482957021023 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957021024 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957021025 trimer interface [polypeptide binding]; other site 482957021026 eyelet of channel; other site 482957021027 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957021028 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957021029 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957021030 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957021031 trimer interface [polypeptide binding]; other site 482957021032 eyelet of channel; other site 482957021033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021034 D-galactonate transporter; Region: 2A0114; TIGR00893 482957021035 putative substrate translocation pore; other site 482957021036 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957021037 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957021038 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957021039 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 482957021040 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957021041 active site 482957021042 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 482957021043 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 482957021044 acyl-activating enzyme (AAE) consensus motif; other site 482957021045 putative AMP binding site [chemical binding]; other site 482957021046 putative active site [active] 482957021047 putative CoA binding site [chemical binding]; other site 482957021048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021051 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957021052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021053 putative substrate translocation pore; other site 482957021054 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 482957021055 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 482957021056 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 482957021057 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 482957021058 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 482957021059 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957021060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021063 dimerization interface [polypeptide binding]; other site 482957021064 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957021065 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957021066 trimer interface [polypeptide binding]; other site 482957021067 eyelet of channel; other site 482957021068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957021070 putative substrate translocation pore; other site 482957021071 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 482957021072 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 482957021073 FMN-binding pocket [chemical binding]; other site 482957021074 flavin binding motif; other site 482957021075 phosphate binding motif [ion binding]; other site 482957021076 beta-alpha-beta structure motif; other site 482957021077 NAD binding pocket [chemical binding]; other site 482957021078 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957021079 catalytic loop [active] 482957021080 iron binding site [ion binding]; other site 482957021081 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 482957021082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021083 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 482957021084 substrate binding pocket [chemical binding]; other site 482957021085 dimerization interface [polypeptide binding]; other site 482957021086 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 482957021087 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 482957021088 [2Fe-2S] cluster binding site [ion binding]; other site 482957021089 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 482957021090 putative alpha subunit interface [polypeptide binding]; other site 482957021091 putative active site [active] 482957021092 putative substrate binding site [chemical binding]; other site 482957021093 Fe binding site [ion binding]; other site 482957021094 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 482957021095 inter-subunit interface; other site 482957021096 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 482957021097 active site 1 [active] 482957021098 dimer interface [polypeptide binding]; other site 482957021099 hexamer interface [polypeptide binding]; other site 482957021100 active site 2 [active] 482957021101 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 482957021102 active site 1 [active] 482957021103 dimer interface [polypeptide binding]; other site 482957021104 hexamer interface [polypeptide binding]; other site 482957021105 active site 2 [active] 482957021106 PAS domain; Region: PAS_9; pfam13426 482957021107 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 482957021108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957021109 putative active site [active] 482957021110 heme pocket [chemical binding]; other site 482957021111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957021112 dimer interface [polypeptide binding]; other site 482957021113 phosphorylation site [posttranslational modification] 482957021114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957021115 ATP binding site [chemical binding]; other site 482957021116 Mg2+ binding site [ion binding]; other site 482957021117 G-X-G motif; other site 482957021118 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957021119 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957021120 active site 482957021121 SnoaL-like domain; Region: SnoaL_4; pfam13577 482957021122 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 482957021123 Amidase; Region: Amidase; cl11426 482957021124 Amidase; Region: Amidase; cl11426 482957021125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 482957021126 classical (c) SDRs; Region: SDR_c; cd05233 482957021127 NAD(P) binding site [chemical binding]; other site 482957021128 active site 482957021129 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 482957021130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957021131 active site 482957021132 phosphorylation site [posttranslational modification] 482957021133 intermolecular recognition site; other site 482957021134 dimerization interface [polypeptide binding]; other site 482957021135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957021136 DNA binding residues [nucleotide binding] 482957021137 dimerization interface [polypeptide binding]; other site 482957021138 Flavin Reductases; Region: FlaRed; cl00801 482957021139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021140 putative substrate translocation pore; other site 482957021141 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957021142 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 482957021143 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957021144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957021145 putative DNA binding site [nucleotide binding]; other site 482957021146 putative Zn2+ binding site [ion binding]; other site 482957021147 AsnC family; Region: AsnC_trans_reg; pfam01037 482957021148 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 482957021149 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 482957021150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957021151 Coenzyme A binding pocket [chemical binding]; other site 482957021152 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957021153 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957021154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021155 choline dehydrogenase; Validated; Region: PRK02106 482957021156 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957021157 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957021158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 482957021159 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957021160 Low molecular weight phosphatase family; Region: LMWPc; cd00115 482957021161 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 482957021162 active site 482957021163 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 482957021164 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 482957021165 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 482957021166 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 482957021167 active site 482957021168 LssY C-terminus; Region: LssY_C; pfam14067 482957021169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957021170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957021171 active site 482957021172 phosphorylation site [posttranslational modification] 482957021173 intermolecular recognition site; other site 482957021174 dimerization interface [polypeptide binding]; other site 482957021175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957021176 DNA binding residues [nucleotide binding] 482957021177 dimerization interface [polypeptide binding]; other site 482957021178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 482957021179 Histidine kinase; Region: HisKA_3; pfam07730 482957021180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021181 D-galactonate transporter; Region: 2A0114; TIGR00893 482957021182 putative substrate translocation pore; other site 482957021183 NMT1-like family; Region: NMT1_2; pfam13379 482957021184 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 482957021185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957021186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957021187 active site 482957021188 phosphorylation site [posttranslational modification] 482957021189 intermolecular recognition site; other site 482957021190 dimerization interface [polypeptide binding]; other site 482957021191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957021192 DNA binding site [nucleotide binding] 482957021193 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 482957021194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957021195 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 482957021196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957021197 dimer interface [polypeptide binding]; other site 482957021198 phosphorylation site [posttranslational modification] 482957021199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957021200 ATP binding site [chemical binding]; other site 482957021201 Mg2+ binding site [ion binding]; other site 482957021202 G-X-G motif; other site 482957021203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957021204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957021205 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 482957021206 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957021207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021208 putative substrate translocation pore; other site 482957021209 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 482957021210 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 482957021211 NAD binding site [chemical binding]; other site 482957021212 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 482957021213 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 482957021214 Walker A/P-loop; other site 482957021215 ATP binding site [chemical binding]; other site 482957021216 Q-loop/lid; other site 482957021217 ABC transporter signature motif; other site 482957021218 Walker B; other site 482957021219 D-loop; other site 482957021220 H-loop/switch region; other site 482957021221 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 482957021222 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 482957021223 Walker A/P-loop; other site 482957021224 ATP binding site [chemical binding]; other site 482957021225 Q-loop/lid; other site 482957021226 ABC transporter signature motif; other site 482957021227 Walker B; other site 482957021228 D-loop; other site 482957021229 H-loop/switch region; other site 482957021230 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 482957021231 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 482957021232 TM-ABC transporter signature motif; other site 482957021233 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 482957021234 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 482957021235 TM-ABC transporter signature motif; other site 482957021236 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957021237 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems; Region: PBP1_ABC_ligand_binding_like_14; cd06349 482957021238 putative ligand binding site [chemical binding]; other site 482957021239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021242 dimerization interface [polypeptide binding]; other site 482957021243 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 482957021244 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 482957021245 hydroxyglutarate oxidase; Provisional; Region: PRK11728 482957021246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 482957021247 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 482957021248 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 482957021249 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 482957021250 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957021251 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 482957021252 putative DNA binding site [nucleotide binding]; other site 482957021253 putative Zn2+ binding site [ion binding]; other site 482957021254 AsnC family; Region: AsnC_trans_reg; pfam01037 482957021255 ornithine cyclodeaminase; Validated; Region: PRK07589 482957021256 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 482957021257 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 482957021258 Amidinotransferase; Region: Amidinotransf; pfam02274 482957021259 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 482957021260 nucleotide binding site [chemical binding]; other site 482957021261 putative NEF/HSP70 interaction site [polypeptide binding]; other site 482957021262 SBD interface [polypeptide binding]; other site 482957021263 DNA-K related protein; Region: DUF3731; pfam12531 482957021264 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 482957021265 nucleotide binding site [chemical binding]; other site 482957021266 putative NEF/HSP70 interaction site [polypeptide binding]; other site 482957021267 SBD interface [polypeptide binding]; other site 482957021268 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 482957021269 Predicted transcriptional regulator [Transcription]; Region: COG1959 482957021270 Transcriptional regulator; Region: Rrf2; pfam02082 482957021271 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 482957021272 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 482957021273 benzoate transport; Region: 2A0115; TIGR00895 482957021274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021275 putative substrate translocation pore; other site 482957021276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021277 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 482957021278 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 482957021279 putative active site [active] 482957021280 metal binding site [ion binding]; metal-binding site 482957021281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021282 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 482957021283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957021284 dimerization interface [polypeptide binding]; other site 482957021285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021288 dimerization interface [polypeptide binding]; other site 482957021289 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 482957021290 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 482957021291 active site 482957021292 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957021293 dimer interface [polypeptide binding]; other site 482957021294 substrate binding site [chemical binding]; other site 482957021295 catalytic residue [active] 482957021296 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 482957021297 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 482957021298 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 482957021299 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957021300 motif II; other site 482957021301 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 482957021302 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 482957021303 putative C-terminal domain interface [polypeptide binding]; other site 482957021304 putative GSH binding site (G-site) [chemical binding]; other site 482957021305 putative dimer interface [polypeptide binding]; other site 482957021306 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 482957021307 dimer interface [polypeptide binding]; other site 482957021308 N-terminal domain interface [polypeptide binding]; other site 482957021309 putative substrate binding pocket (H-site) [chemical binding]; other site 482957021310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 482957021311 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 482957021312 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 482957021313 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 482957021314 tetramer interface [polypeptide binding]; other site 482957021315 active site 482957021316 Mg2+/Mn2+ binding site [ion binding]; other site 482957021317 Uncharacterized conserved protein [Function unknown]; Region: COG2128 482957021318 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957021319 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957021320 non-specific DNA binding site [nucleotide binding]; other site 482957021321 salt bridge; other site 482957021322 sequence-specific DNA binding site [nucleotide binding]; other site 482957021323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021324 putative substrate translocation pore; other site 482957021325 Cupin; Region: Cupin_6; pfam12852 482957021326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021327 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957021328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021329 Heterokaryon incompatibility protein Het-C; Region: Het-C; pfam07217 482957021330 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 482957021331 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 482957021332 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 482957021333 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 482957021334 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 482957021335 enoyl-CoA hydratase; Validated; Region: PRK08788 482957021336 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 482957021337 substrate binding site [chemical binding]; other site 482957021338 oxyanion hole (OAH) forming residues; other site 482957021339 trimer interface [polypeptide binding]; other site 482957021340 RNase II stability modulator; Provisional; Region: PRK10060 482957021341 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 482957021342 metal binding site [ion binding]; metal-binding site 482957021343 active site 482957021344 I-site; other site 482957021345 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957021346 5-oxoprolinase; Region: PLN02666 482957021347 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 482957021348 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 482957021349 Amidase; Region: Amidase; cl11426 482957021350 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 482957021351 benzoate transport; Region: 2A0115; TIGR00895 482957021352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021353 putative substrate translocation pore; other site 482957021354 hypothetical protein; Provisional; Region: PRK05463 482957021355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957021358 dimerization interface [polypeptide binding]; other site 482957021359 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 482957021360 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 482957021361 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 482957021362 Uncharacterized conserved protein [Function unknown]; Region: COG1262 482957021363 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 482957021364 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 482957021365 Sulfatase; Region: Sulfatase; cl17466 482957021366 Sulfatase; Region: Sulfatase; cl17466 482957021367 Sulfatase; Region: Sulfatase; cl17466 482957021368 short chain dehydrogenase; Provisional; Region: PRK07577 482957021369 classical (c) SDRs; Region: SDR_c; cd05233 482957021370 NAD(P) binding site [chemical binding]; other site 482957021371 active site 482957021372 Curli assembly protein CsgE; Region: CsgE; pfam10627 482957021373 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 482957021374 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 482957021375 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 482957021376 major curlin subunit; Provisional; Region: csgA; PRK10051 482957021377 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 482957021378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021379 putative substrate translocation pore; other site 482957021380 EamA-like transporter family; Region: EamA; pfam00892 482957021381 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 482957021382 EamA-like transporter family; Region: EamA; pfam00892 482957021383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021385 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 482957021386 putative effector binding pocket; other site 482957021387 putative dimerization interface [polypeptide binding]; other site 482957021388 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 482957021389 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957021390 putative NAD(P) binding site [chemical binding]; other site 482957021391 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957021392 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957021393 trimer interface [polypeptide binding]; other site 482957021394 eyelet of channel; other site 482957021395 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 482957021396 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 482957021397 substrate binding pocket [chemical binding]; other site 482957021398 membrane-bound complex binding site; other site 482957021399 hinge residues; other site 482957021400 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 482957021401 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 482957021402 metal binding site [ion binding]; metal-binding site 482957021403 putative dimer interface [polypeptide binding]; other site 482957021404 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 482957021405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021407 dimerization interface [polypeptide binding]; other site 482957021408 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957021409 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957021410 N-terminal plug; other site 482957021411 ligand-binding site [chemical binding]; other site 482957021412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957021414 putative substrate translocation pore; other site 482957021415 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 482957021416 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 482957021417 TolR protein; Region: tolR; TIGR02801 482957021418 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 482957021419 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 482957021420 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 482957021421 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 482957021422 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 482957021423 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 482957021424 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 482957021425 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 482957021426 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 482957021427 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957021428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 482957021429 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 482957021430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957021431 putative PBP binding loops; other site 482957021432 dimer interface [polypeptide binding]; other site 482957021433 ABC-ATPase subunit interface; other site 482957021434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957021435 Walker A motif; other site 482957021436 ATP binding site [chemical binding]; other site 482957021437 Walker B motif; other site 482957021438 arginine finger; other site 482957021439 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 482957021440 active site 482957021441 Zn2+ binding site [ion binding]; other site 482957021442 intersubunit interface [polypeptide binding]; other site 482957021443 Secretory lipase; Region: LIP; pfam03583 482957021444 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 482957021445 oligomerisation interface [polypeptide binding]; other site 482957021446 mobile loop; other site 482957021447 roof hairpin; other site 482957021448 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 482957021449 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 482957021450 ring oligomerisation interface [polypeptide binding]; other site 482957021451 ATP/Mg binding site [chemical binding]; other site 482957021452 stacking interactions; other site 482957021453 hinge regions; other site 482957021454 LysE type translocator; Region: LysE; cl00565 482957021455 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 482957021456 active site 482957021457 phosphorylation site [posttranslational modification] 482957021458 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 482957021459 nucleotide binding site [chemical binding]; other site 482957021460 substrate binding site [chemical binding]; other site 482957021461 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 482957021462 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 482957021463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957021464 catalytic residue [active] 482957021465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957021466 non-specific DNA binding site [nucleotide binding]; other site 482957021467 salt bridge; other site 482957021468 sequence-specific DNA binding site [nucleotide binding]; other site 482957021469 serine O-acetyltransferase; Region: cysE; TIGR01172 482957021470 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 482957021471 trimer interface [polypeptide binding]; other site 482957021472 active site 482957021473 substrate binding site [chemical binding]; other site 482957021474 CoA binding site [chemical binding]; other site 482957021475 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 482957021476 active site residue [active] 482957021477 amidase; Provisional; Region: PRK07487 482957021478 Amidase; Region: Amidase; cl11426 482957021479 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 482957021480 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 482957021481 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957021482 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957021483 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 482957021484 propionate/acetate kinase; Provisional; Region: PRK12379 482957021485 phosphate acetyltransferase; Provisional; Region: PRK11890 482957021486 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 482957021487 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 482957021488 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 482957021489 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 482957021490 NAD binding site [chemical binding]; other site 482957021491 homotetramer interface [polypeptide binding]; other site 482957021492 homodimer interface [polypeptide binding]; other site 482957021493 substrate binding site [chemical binding]; other site 482957021494 active site 482957021495 EthD domain; Region: EthD; cl17553 482957021496 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 482957021497 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021498 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021499 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021500 dimerization interface [polypeptide binding]; other site 482957021501 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 482957021502 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 482957021503 putative active site [active] 482957021504 putative catalytic site [active] 482957021505 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957021506 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 482957021507 active site 482957021508 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957021509 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 482957021510 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957021511 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957021512 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957021513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021514 D-galactonate transporter; Region: 2A0114; TIGR00893 482957021515 putative substrate translocation pore; other site 482957021516 Epoxide hydrolase N terminus; Region: EHN; pfam06441 482957021517 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957021518 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 482957021519 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 482957021520 putative NAD(P) binding site [chemical binding]; other site 482957021521 putative active site [active] 482957021522 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957021523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021524 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957021525 dimerization interface [polypeptide binding]; other site 482957021526 substrate binding pocket [chemical binding]; other site 482957021527 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 482957021528 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 482957021529 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 482957021530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957021531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957021532 homodimer interface [polypeptide binding]; other site 482957021533 catalytic residue [active] 482957021534 hypothetical protein; Provisional; Region: PRK09936 482957021535 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 482957021536 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 482957021537 NodB motif; other site 482957021538 putative active site [active] 482957021539 putative catalytic site [active] 482957021540 putative Zn binding site [ion binding]; other site 482957021541 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 482957021542 active site 482957021543 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 482957021544 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 482957021545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 482957021546 TPR motif; other site 482957021547 binding surface 482957021548 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 482957021549 malic enzyme; Reviewed; Region: PRK12861 482957021550 Malic enzyme, N-terminal domain; Region: malic; pfam00390 482957021551 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 482957021552 putative NAD(P) binding site [chemical binding]; other site 482957021553 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 482957021554 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 482957021555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021557 dimerization interface [polypeptide binding]; other site 482957021558 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 482957021559 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 482957021560 DNA binding residues [nucleotide binding] 482957021561 putative dimer interface [polypeptide binding]; other site 482957021562 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 482957021563 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 482957021564 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 482957021565 Leucine carboxyl methyltransferase; Region: LCM; cl01306 482957021566 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 482957021567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957021568 Coenzyme A binding pocket [chemical binding]; other site 482957021569 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 482957021570 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 482957021571 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957021572 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957021573 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 482957021574 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957021575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021576 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957021577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 482957021579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957021580 Coenzyme A binding pocket [chemical binding]; other site 482957021581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021582 putative substrate translocation pore; other site 482957021583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957021584 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957021585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021586 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957021587 dimerization interface [polypeptide binding]; other site 482957021588 substrate binding pocket [chemical binding]; other site 482957021589 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 482957021590 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957021591 catalytic residue [active] 482957021592 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 482957021593 Beta-lactamase; Region: Beta-lactamase; pfam00144 482957021594 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957021595 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957021596 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957021597 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957021598 dimerization interface [polypeptide binding]; other site 482957021599 ligand binding site [chemical binding]; other site 482957021600 CsbD-like; Region: CsbD; pfam05532 482957021601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 482957021602 PAS domain; Region: PAS_9; pfam13426 482957021603 PAS domain S-box; Region: sensory_box; TIGR00229 482957021604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957021605 putative active site [active] 482957021606 heme pocket [chemical binding]; other site 482957021607 PAS domain S-box; Region: sensory_box; TIGR00229 482957021608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 482957021609 putative active site [active] 482957021610 heme pocket [chemical binding]; other site 482957021611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957021612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957021613 DNA binding residues [nucleotide binding] 482957021614 dimerization interface [polypeptide binding]; other site 482957021615 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 482957021616 CsbD-like; Region: CsbD; cl17424 482957021617 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 482957021618 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 482957021619 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957021620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021622 dimerization interface [polypeptide binding]; other site 482957021623 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957021624 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 482957021625 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 482957021626 Ankyrin repeat; Region: Ank; pfam00023 482957021627 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 482957021628 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 482957021629 tetrameric interface [polypeptide binding]; other site 482957021630 activator binding site; other site 482957021631 NADP binding site [chemical binding]; other site 482957021632 substrate binding site [chemical binding]; other site 482957021633 catalytic residues [active] 482957021634 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 482957021635 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 482957021636 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 482957021637 active site 482957021638 citrate-proton symporter; Provisional; Region: PRK15075 482957021639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021640 putative substrate translocation pore; other site 482957021641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021643 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 482957021644 substrate binding pocket [chemical binding]; other site 482957021645 dimerization interface [polypeptide binding]; other site 482957021646 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957021647 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 482957021648 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 482957021649 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 482957021650 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957021651 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957021652 N-terminal plug; other site 482957021653 ligand-binding site [chemical binding]; other site 482957021654 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 482957021655 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 482957021656 N-terminal plug; other site 482957021657 ligand-binding site [chemical binding]; other site 482957021658 CopC domain; Region: CopC; pfam04234 482957021659 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 482957021660 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 482957021661 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 482957021662 putative active site [active] 482957021663 putative FMN binding site [chemical binding]; other site 482957021664 putative substrate binding site [chemical binding]; other site 482957021665 putative catalytic residue [active] 482957021666 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 482957021667 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 482957021668 DNA binding residues [nucleotide binding] 482957021669 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957021670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957021671 active site 482957021672 phosphorylation site [posttranslational modification] 482957021673 intermolecular recognition site; other site 482957021674 dimerization interface [polypeptide binding]; other site 482957021675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957021676 DNA binding residues [nucleotide binding] 482957021677 dimerization interface [polypeptide binding]; other site 482957021678 CHASE domain; Region: CHASE; pfam03924 482957021679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 482957021680 Histidine kinase; Region: HisKA_3; pfam07730 482957021681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957021682 ATP binding site [chemical binding]; other site 482957021683 Mg2+ binding site [ion binding]; other site 482957021684 G-X-G motif; other site 482957021685 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 482957021686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957021687 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 482957021688 NAD(P) binding site [chemical binding]; other site 482957021689 active site 482957021690 Transcriptional regulators [Transcription]; Region: PurR; COG1609 482957021691 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 482957021692 DNA binding site [nucleotide binding] 482957021693 domain linker motif; other site 482957021694 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 482957021695 dimerization interface [polypeptide binding]; other site 482957021696 ligand binding site [chemical binding]; other site 482957021697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021698 D-galactonate transporter; Region: 2A0114; TIGR00893 482957021699 putative substrate translocation pore; other site 482957021700 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 482957021701 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 482957021702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021704 AlkA N-terminal domain; Region: AlkA_N; pfam06029 482957021705 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 482957021706 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 482957021707 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 482957021708 DNA binding site [nucleotide binding] 482957021709 active site 482957021710 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 482957021711 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957021712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021713 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 482957021714 oligomerization interface [polypeptide binding]; other site 482957021715 active site 482957021716 metal binding site [ion binding]; metal-binding site 482957021717 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 482957021718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957021719 AsnC family; Region: AsnC_trans_reg; pfam01037 482957021720 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 482957021721 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 482957021722 glutaminase active site [active] 482957021723 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 482957021724 dimer interface [polypeptide binding]; other site 482957021725 active site 482957021726 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 482957021727 dimer interface [polypeptide binding]; other site 482957021728 active site 482957021729 Tetratricopeptide repeat; Region: TPR_9; pfam13371 482957021730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 482957021731 TPR motif; other site 482957021732 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 482957021733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957021734 dimerization interface [polypeptide binding]; other site 482957021735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957021736 dimer interface [polypeptide binding]; other site 482957021737 phosphorylation site [posttranslational modification] 482957021738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957021739 ATP binding site [chemical binding]; other site 482957021740 Mg2+ binding site [ion binding]; other site 482957021741 G-X-G motif; other site 482957021742 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957021743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957021744 active site 482957021745 phosphorylation site [posttranslational modification] 482957021746 intermolecular recognition site; other site 482957021747 dimerization interface [polypeptide binding]; other site 482957021748 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957021749 DNA binding site [nucleotide binding] 482957021750 MltA-interacting protein MipA; Region: MipA; cl01504 482957021751 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957021752 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957021753 trimer interface [polypeptide binding]; other site 482957021754 eyelet of channel; other site 482957021755 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 482957021756 iron-sulfur cluster [ion binding]; other site 482957021757 [2Fe-2S] cluster binding site [ion binding]; other site 482957021758 YciI-like protein; Reviewed; Region: PRK12863 482957021759 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 482957021760 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 482957021761 active site 482957021762 dimer interface [polypeptide binding]; other site 482957021763 metal binding site [ion binding]; metal-binding site 482957021764 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957021765 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 482957021766 NAD(P) binding site [chemical binding]; other site 482957021767 catalytic residues [active] 482957021768 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 482957021769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021771 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957021772 putative effector binding pocket; other site 482957021773 dimerization interface [polypeptide binding]; other site 482957021774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957021776 putative substrate translocation pore; other site 482957021777 NIPSNAP; Region: NIPSNAP; pfam07978 482957021778 NIPSNAP; Region: NIPSNAP; pfam07978 482957021779 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957021780 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 482957021781 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957021782 catalytic residue [active] 482957021783 Putative phosphatase (DUF442); Region: DUF442; cl17385 482957021784 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 482957021785 conserved cys residue [active] 482957021786 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 482957021787 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 482957021788 conserved cys residue [active] 482957021789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957021791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021793 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957021794 putative effector binding pocket; other site 482957021795 dimerization interface [polypeptide binding]; other site 482957021796 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 482957021797 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957021798 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 482957021799 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 482957021800 putative active site [active] 482957021801 putative NTP binding site [chemical binding]; other site 482957021802 putative nucleic acid binding site [nucleotide binding]; other site 482957021803 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 482957021804 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 482957021805 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 482957021806 dimer interface [polypeptide binding]; other site 482957021807 active site 482957021808 glycine-pyridoxal phosphate binding site [chemical binding]; other site 482957021809 folate binding site [chemical binding]; other site 482957021810 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 482957021811 classical (c) SDRs; Region: SDR_c; cd05233 482957021812 NAD(P) binding site [chemical binding]; other site 482957021813 active site 482957021814 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 482957021815 FAD binding domain; Region: FAD_binding_4; pfam01565 482957021816 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 482957021817 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957021818 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 482957021819 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 482957021820 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 482957021821 generic binding surface I; other site 482957021822 generic binding surface II; other site 482957021823 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 482957021824 putative active site [active] 482957021825 putative catalytic site [active] 482957021826 putative Mg binding site IVb [ion binding]; other site 482957021827 putative phosphate binding site [ion binding]; other site 482957021828 putative DNA binding site [nucleotide binding]; other site 482957021829 putative Mg binding site IVa [ion binding]; other site 482957021830 CopC domain; Region: CopC; pfam04234 482957021831 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 482957021832 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 482957021833 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 482957021834 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 482957021835 Outer membrane efflux protein; Region: OEP; pfam02321 482957021836 Outer membrane efflux protein; Region: OEP; pfam02321 482957021837 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 482957021838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957021839 active site 482957021840 phosphorylation site [posttranslational modification] 482957021841 intermolecular recognition site; other site 482957021842 dimerization interface [polypeptide binding]; other site 482957021843 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957021844 DNA binding site [nucleotide binding] 482957021845 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 482957021846 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 482957021847 dimerization interface [polypeptide binding]; other site 482957021848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957021849 dimer interface [polypeptide binding]; other site 482957021850 phosphorylation site [posttranslational modification] 482957021851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957021852 ATP binding site [chemical binding]; other site 482957021853 Mg2+ binding site [ion binding]; other site 482957021854 G-X-G motif; other site 482957021855 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 482957021856 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 482957021857 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 482957021858 glutathionine S-transferase; Provisional; Region: PRK10542 482957021859 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 482957021860 C-terminal domain interface [polypeptide binding]; other site 482957021861 GSH binding site (G-site) [chemical binding]; other site 482957021862 dimer interface [polypeptide binding]; other site 482957021863 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 482957021864 dimer interface [polypeptide binding]; other site 482957021865 N-terminal domain interface [polypeptide binding]; other site 482957021866 substrate binding pocket (H-site) [chemical binding]; other site 482957021867 Predicted transcriptional regulators [Transcription]; Region: COG1733 482957021868 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 482957021869 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 482957021870 substrate binding site [chemical binding]; other site 482957021871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957021872 D-galactonate transporter; Region: 2A0114; TIGR00893 482957021873 putative substrate translocation pore; other site 482957021874 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 482957021875 active site 482957021876 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 482957021877 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 482957021878 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 482957021879 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 482957021880 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 482957021881 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 482957021882 active site 482957021883 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957021884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957021885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957021886 DNA binding residues [nucleotide binding] 482957021887 dimerization interface [polypeptide binding]; other site 482957021888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957021891 dimerization interface [polypeptide binding]; other site 482957021892 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 482957021893 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 482957021894 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 482957021895 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957021896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957021897 DNA binding residues [nucleotide binding] 482957021898 dimerization interface [polypeptide binding]; other site 482957021899 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 482957021900 agmatinase; Region: agmatinase; TIGR01230 482957021901 oligomer interface [polypeptide binding]; other site 482957021902 putative active site [active] 482957021903 Mn binding site [ion binding]; other site 482957021904 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 482957021905 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957021906 NAD(P) binding site [chemical binding]; other site 482957021907 catalytic residues [active] 482957021908 catalytic residues [active] 482957021909 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 482957021910 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 482957021911 active site 482957021912 nucleophile elbow; other site 482957021913 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 482957021914 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 482957021915 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 482957021916 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 482957021917 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 482957021918 ligand binding site [chemical binding]; other site 482957021919 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 482957021920 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 482957021921 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 482957021922 metal coordination site [ion binding]; other site 482957021923 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 482957021924 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 482957021925 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 482957021926 MgtC family; Region: MgtC; pfam02308 482957021927 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 482957021928 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957021929 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 482957021930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 482957021931 motif II; other site 482957021932 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 482957021933 Phosphoesterase family; Region: Phosphoesterase; pfam04185 482957021934 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957021935 Domain of unknown function (DUF756); Region: DUF756; pfam05506 482957021936 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 482957021937 active site 482957021938 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957021939 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957021940 trimer interface [polypeptide binding]; other site 482957021941 eyelet of channel; other site 482957021942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957021943 Coenzyme A binding pocket [chemical binding]; other site 482957021944 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 482957021945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957021946 S-adenosylmethionine binding site [chemical binding]; other site 482957021947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021949 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 482957021950 putative dimerization interface [polypeptide binding]; other site 482957021951 methionine gamma-lyase; Validated; Region: PRK07049 482957021952 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 482957021953 homodimer interface [polypeptide binding]; other site 482957021954 substrate-cofactor binding pocket; other site 482957021955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957021956 catalytic residue [active] 482957021957 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 482957021958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957021959 dimer interface [polypeptide binding]; other site 482957021960 conserved gate region; other site 482957021961 putative PBP binding loops; other site 482957021962 ABC-ATPase subunit interface; other site 482957021963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957021964 dimer interface [polypeptide binding]; other site 482957021965 conserved gate region; other site 482957021966 putative PBP binding loops; other site 482957021967 ABC-ATPase subunit interface; other site 482957021968 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 482957021969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 482957021970 Walker A/P-loop; other site 482957021971 ATP binding site [chemical binding]; other site 482957021972 Q-loop/lid; other site 482957021973 ABC transporter signature motif; other site 482957021974 Walker B; other site 482957021975 D-loop; other site 482957021976 H-loop/switch region; other site 482957021977 TOBE domain; Region: TOBE_2; pfam08402 482957021978 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 482957021979 nucleoside/Zn binding site; other site 482957021980 dimer interface [polypeptide binding]; other site 482957021981 catalytic motif [active] 482957021982 cyanate hydratase; Validated; Region: PRK02866 482957021983 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 482957021984 oligomer interface [polypeptide binding]; other site 482957021985 active site 482957021986 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 482957021987 active site clefts [active] 482957021988 zinc binding site [ion binding]; other site 482957021989 dimer interface [polypeptide binding]; other site 482957021990 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 482957021991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021992 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 482957021993 dimerization interface [polypeptide binding]; other site 482957021994 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 482957021995 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 482957021996 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957021997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957021998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957021999 dimerization interface [polypeptide binding]; other site 482957022000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022003 dimerization interface [polypeptide binding]; other site 482957022004 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 482957022005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957022006 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957022007 active site 482957022008 catalytic tetrad [active] 482957022009 succinic semialdehyde dehydrogenase; Region: PLN02278 482957022010 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 482957022011 tetramerization interface [polypeptide binding]; other site 482957022012 NAD(P) binding site [chemical binding]; other site 482957022013 catalytic residues [active] 482957022014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022015 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 482957022016 putative substrate translocation pore; other site 482957022017 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 482957022018 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 482957022019 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 482957022020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022022 dimerization interface [polypeptide binding]; other site 482957022023 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 482957022024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022025 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 482957022026 dimerization interface [polypeptide binding]; other site 482957022027 substrate binding pocket [chemical binding]; other site 482957022028 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 482957022029 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957022030 NAD binding site [chemical binding]; other site 482957022031 catalytic residues [active] 482957022032 substrate binding site [chemical binding]; other site 482957022033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957022035 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 482957022036 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 482957022037 active site pocket [active] 482957022038 choline dehydrogenase; Validated; Region: PRK02106 482957022039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 482957022040 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957022041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022043 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 482957022044 putative substrate binding pocket [chemical binding]; other site 482957022045 putative dimerization interface [polypeptide binding]; other site 482957022046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 482957022047 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 482957022048 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 482957022049 Walker A/P-loop; other site 482957022050 ATP binding site [chemical binding]; other site 482957022051 Q-loop/lid; other site 482957022052 ABC transporter signature motif; other site 482957022053 Walker B; other site 482957022054 D-loop; other site 482957022055 H-loop/switch region; other site 482957022056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957022057 dimer interface [polypeptide binding]; other site 482957022058 conserved gate region; other site 482957022059 putative PBP binding loops; other site 482957022060 ABC-ATPase subunit interface; other site 482957022061 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 482957022062 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 482957022063 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022064 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022065 trimer interface [polypeptide binding]; other site 482957022066 eyelet of channel; other site 482957022067 RDD family; Region: RDD; pfam06271 482957022068 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 482957022069 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 482957022070 Acyltransferase family; Region: Acyl_transf_3; pfam01757 482957022071 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 482957022072 Alkaline phosphatase homologues; Region: alkPPc; smart00098 482957022073 active site 482957022074 dimer interface [polypeptide binding]; other site 482957022075 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 482957022076 Alkaline phosphatase homologues; Region: alkPPc; smart00098 482957022077 active site 482957022078 dimer interface [polypeptide binding]; other site 482957022079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957022080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957022081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957022082 active site 482957022083 catalytic tetrad [active] 482957022084 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022086 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 482957022087 putative effector binding pocket; other site 482957022088 putative dimerization interface [polypeptide binding]; other site 482957022089 putative acetyltransferase; Provisional; Region: PRK03624 482957022090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957022091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957022092 Coenzyme A binding pocket [chemical binding]; other site 482957022093 pyruvate dehydrogenase; Provisional; Region: PRK09124 482957022094 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 482957022095 PYR/PP interface [polypeptide binding]; other site 482957022096 tetramer interface [polypeptide binding]; other site 482957022097 dimer interface [polypeptide binding]; other site 482957022098 TPP binding site [chemical binding]; other site 482957022099 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 482957022100 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 482957022101 TPP-binding site [chemical binding]; other site 482957022102 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957022103 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 482957022104 putative DNA binding site [nucleotide binding]; other site 482957022105 putative Zn2+ binding site [ion binding]; other site 482957022106 AsnC family; Region: AsnC_trans_reg; pfam01037 482957022107 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 482957022108 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 482957022109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957022110 catalytic residue [active] 482957022111 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 482957022112 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 482957022113 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 482957022114 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 482957022115 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 482957022116 Bacterial sugar transferase; Region: Bac_transf; pfam02397 482957022117 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 482957022118 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 482957022119 Low molecular weight phosphatase family; Region: LMWPc; cd00115 482957022120 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 482957022121 active site 482957022122 tyrosine kinase; Provisional; Region: PRK11519 482957022123 Chain length determinant protein; Region: Wzz; pfam02706 482957022124 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 482957022125 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 482957022126 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 482957022127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957022128 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 482957022129 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 482957022130 Acyltransferase family; Region: Acyl_transf_3; pfam01757 482957022131 putative fimbrial protein TcfA; Provisional; Region: PRK15308 482957022132 putative fimbrial protein TcfA; Provisional; Region: PRK15308 482957022133 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 482957022134 Immunoglobulin domain; Region: Ig; cl11960 482957022135 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524 482957022136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957022137 dimer interface [polypeptide binding]; other site 482957022138 phosphorylation site [posttranslational modification] 482957022139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957022140 ATP binding site [chemical binding]; other site 482957022141 Mg2+ binding site [ion binding]; other site 482957022142 G-X-G motif; other site 482957022143 Response regulator receiver domain; Region: Response_reg; pfam00072 482957022144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957022145 active site 482957022146 phosphorylation site [posttranslational modification] 482957022147 intermolecular recognition site; other site 482957022148 dimerization interface [polypeptide binding]; other site 482957022149 transcriptional regulator RcsB; Provisional; Region: PRK10840 482957022150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957022151 active site 482957022152 phosphorylation site [posttranslational modification] 482957022153 intermolecular recognition site; other site 482957022154 dimerization interface [polypeptide binding]; other site 482957022155 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957022156 DNA binding residues [nucleotide binding] 482957022157 dimerization interface [polypeptide binding]; other site 482957022158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957022159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957022160 dimer interface [polypeptide binding]; other site 482957022161 phosphorylation site [posttranslational modification] 482957022162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957022163 ATP binding site [chemical binding]; other site 482957022164 Mg2+ binding site [ion binding]; other site 482957022165 G-X-G motif; other site 482957022166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957022167 Response regulator receiver domain; Region: Response_reg; pfam00072 482957022168 active site 482957022169 phosphorylation site [posttranslational modification] 482957022170 intermolecular recognition site; other site 482957022171 dimerization interface [polypeptide binding]; other site 482957022172 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 482957022173 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957022174 Sel1-like repeats; Region: SEL1; smart00671 482957022175 BetR domain; Region: BetR; pfam08667 482957022176 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 482957022177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957022178 active site 482957022179 phosphorylation site [posttranslational modification] 482957022180 intermolecular recognition site; other site 482957022181 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 482957022182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957022183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957022184 dimer interface [polypeptide binding]; other site 482957022185 phosphorylation site [posttranslational modification] 482957022186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957022187 ATP binding site [chemical binding]; other site 482957022188 Mg2+ binding site [ion binding]; other site 482957022189 G-X-G motif; other site 482957022190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957022191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957022192 active site 482957022193 phosphorylation site [posttranslational modification] 482957022194 intermolecular recognition site; other site 482957022195 dimerization interface [polypeptide binding]; other site 482957022196 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 482957022197 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 482957022198 catalytic residues [active] 482957022199 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 482957022200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022201 putative substrate translocation pore; other site 482957022202 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 482957022203 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957022204 hypothetical protein; Provisional; Region: PRK11470 482957022205 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957022206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957022207 putative DNA binding site [nucleotide binding]; other site 482957022208 putative Zn2+ binding site [ion binding]; other site 482957022209 AsnC family; Region: AsnC_trans_reg; pfam01037 482957022210 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 482957022211 Predicted membrane protein [Function unknown]; Region: COG4541 482957022212 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 482957022213 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 482957022214 classical (c) SDRs; Region: SDR_c; cd05233 482957022215 NAD(P) binding site [chemical binding]; other site 482957022216 active site 482957022217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022218 Major Facilitator Superfamily; Region: MFS_1; pfam07690 482957022219 putative substrate translocation pore; other site 482957022220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957022221 dimerization interface [polypeptide binding]; other site 482957022222 putative DNA binding site [nucleotide binding]; other site 482957022223 putative Zn2+ binding site [ion binding]; other site 482957022224 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 482957022225 active site residue [active] 482957022226 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 482957022227 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 482957022228 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 482957022229 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 482957022230 Cupin domain; Region: Cupin_2; cl17218 482957022231 allantoate amidohydrolase; Reviewed; Region: PRK12892 482957022232 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 482957022233 active site 482957022234 metal binding site [ion binding]; metal-binding site 482957022235 dimer interface [polypeptide binding]; other site 482957022236 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 482957022237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022238 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022239 dimerization interface [polypeptide binding]; other site 482957022240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 482957022241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 482957022242 catalytic residue [active] 482957022243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957022244 dimerization interface [polypeptide binding]; other site 482957022245 putative DNA binding site [nucleotide binding]; other site 482957022246 putative Zn2+ binding site [ion binding]; other site 482957022247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022249 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957022250 putative effector binding pocket; other site 482957022251 dimerization interface [polypeptide binding]; other site 482957022252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957022253 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957022254 active site 482957022255 catalytic tetrad [active] 482957022256 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 482957022257 dimerization interface [polypeptide binding]; other site 482957022258 putative DNA binding site [nucleotide binding]; other site 482957022259 putative Zn2+ binding site [ion binding]; other site 482957022260 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 482957022261 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 482957022262 putative NAD(P) binding site [chemical binding]; other site 482957022263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957022264 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957022265 Coenzyme A binding pocket [chemical binding]; other site 482957022266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 482957022267 S-adenosylmethionine binding site [chemical binding]; other site 482957022268 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 482957022269 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 482957022270 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 482957022271 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 482957022272 catalytic residues [active] 482957022273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022274 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022275 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 482957022276 putative effector binding pocket; other site 482957022277 putative dimerization interface [polypeptide binding]; other site 482957022278 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957022279 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957022280 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 482957022281 Helix-turn-helix domain; Region: HTH_37; pfam13744 482957022282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022283 putative substrate translocation pore; other site 482957022284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022285 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 482957022286 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 482957022287 HlyD family secretion protein; Region: HlyD_3; pfam13437 482957022288 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 482957022289 Cupin domain; Region: Cupin_2; pfam07883 482957022290 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957022291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022294 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957022295 putative effector binding pocket; other site 482957022296 dimerization interface [polypeptide binding]; other site 482957022297 2-isopropylmalate synthase; Validated; Region: PRK03739 482957022298 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 482957022299 active site 482957022300 catalytic residues [active] 482957022301 metal binding site [ion binding]; metal-binding site 482957022302 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 482957022303 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 482957022304 N-Terminal Domain Of Bc2l-C Lectin; Region: Bc2l-C_N; cd12211 482957022305 trimer interface [polypeptide binding]; other site 482957022306 ligand binding site [chemical binding]; other site 482957022307 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 482957022308 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 482957022309 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 482957022310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957022311 Predicted transcriptional regulator [Transcription]; Region: COG1959 482957022312 Transcriptional regulator; Region: Rrf2; pfam02082 482957022313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957022314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 482957022316 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 482957022317 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 482957022318 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 482957022319 Autotransporter beta-domain; Region: Autotransporter; pfam03797 482957022320 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 482957022321 Peptidase family M23; Region: Peptidase_M23; pfam01551 482957022322 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 482957022323 Mechanosensitive ion channel; Region: MS_channel; pfam00924 482957022324 Domain of unknown function (DUF389); Region: DUF389; pfam04087 482957022325 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 482957022326 nudix motif; other site 482957022327 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 482957022328 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 482957022329 dimerization interface [polypeptide binding]; other site 482957022330 ligand binding site [chemical binding]; other site 482957022331 ornithine cyclodeaminase; Validated; Region: PRK07589 482957022332 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 482957022333 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 482957022334 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 482957022335 active site 482957022336 Zn binding site [ion binding]; other site 482957022337 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 482957022338 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 482957022339 AsnC family; Region: AsnC_trans_reg; pfam01037 482957022340 malate:quinone oxidoreductase; Validated; Region: PRK05257 482957022341 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 482957022342 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 482957022343 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 482957022344 ATP binding site [chemical binding]; other site 482957022345 Mg++ binding site [ion binding]; other site 482957022346 motif III; other site 482957022347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 482957022348 nucleotide binding region [chemical binding]; other site 482957022349 ATP-binding site [chemical binding]; other site 482957022350 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 482957022351 putative RNA binding site [nucleotide binding]; other site 482957022352 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 482957022353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022354 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 482957022355 dimerization interface [polypeptide binding]; other site 482957022356 substrate binding pocket [chemical binding]; other site 482957022357 Amidohydrolase; Region: Amidohydro_2; pfam04909 482957022358 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 482957022359 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 482957022360 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 482957022361 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 482957022362 active site 1 [active] 482957022363 dimer interface [polypeptide binding]; other site 482957022364 hexamer interface [polypeptide binding]; other site 482957022365 active site 2 [active] 482957022366 4-oxalocrotonate decarboxylase; Region: catechol_dmpH; TIGR03218 482957022367 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 482957022368 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 482957022369 active site 482957022370 catalytic residues [active] 482957022371 metal binding site [ion binding]; metal-binding site 482957022372 DmpG-like communication domain; Region: DmpG_comm; pfam07836 482957022373 acetaldehyde dehydrogenase; Validated; Region: PRK08300 482957022374 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 482957022375 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 482957022376 2-oxopent-4-enoate hydratase; Region: catechol_dmpE; TIGR03220 482957022377 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 482957022378 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 482957022379 NAD binding site [chemical binding]; other site 482957022380 catalytic residues [active] 482957022381 Domain of unknown function (DUF336); Region: DUF336; pfam03928 482957022382 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 482957022383 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 482957022384 tetramer interface [polypeptide binding]; other site 482957022385 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 482957022386 tetramer interface [polypeptide binding]; other site 482957022387 active site 482957022388 Fe binding site [ion binding]; other site 482957022389 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957022390 catalytic loop [active] 482957022391 iron binding site [ion binding]; other site 482957022392 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 482957022393 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 482957022394 catalytic loop [active] 482957022395 iron binding site [ion binding]; other site 482957022396 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 482957022397 FAD binding pocket [chemical binding]; other site 482957022398 conserved FAD binding motif [chemical binding]; other site 482957022399 phosphate binding motif [ion binding]; other site 482957022400 beta-alpha-beta structure motif; other site 482957022401 NAD binding pocket [chemical binding]; other site 482957022402 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 482957022403 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 482957022404 dimerization interface [polypeptide binding]; other site 482957022405 putative path to active site cavity [active] 482957022406 diiron center [ion binding]; other site 482957022407 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 482957022408 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 482957022409 dinuclear metal binding motif [ion binding]; other site 482957022410 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 482957022411 Activator of aromatic catabolism; Region: XylR_N; pfam06505 482957022412 V4R domain; Region: V4R; pfam02830 482957022413 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 482957022414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 482957022415 Walker A motif; other site 482957022416 ATP binding site [chemical binding]; other site 482957022417 Walker B motif; other site 482957022418 arginine finger; other site 482957022419 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 482957022420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957022421 DNA-binding site [nucleotide binding]; DNA binding site 482957022422 FCD domain; Region: FCD; pfam07729 482957022423 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 482957022424 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 482957022425 Fatty acid desaturase; Region: FA_desaturase; pfam00487 482957022426 putative di-iron ligands [ion binding]; other site 482957022427 benzoate transporter; Region: benE; TIGR00843 482957022428 Benzoate membrane transport protein; Region: BenE; pfam03594 482957022429 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 482957022430 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 482957022431 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 482957022432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957022433 NAD(P) binding site [chemical binding]; other site 482957022434 active site 482957022435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957022437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022440 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 482957022441 putative dimerization interface [polypeptide binding]; other site 482957022442 NADH dehydrogenase-like protein; Provisional; Region: PTZ00318 482957022443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 482957022444 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 482957022445 motif II; other site 482957022446 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 482957022447 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 482957022448 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 482957022449 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 482957022450 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 482957022451 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957022452 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957022453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022454 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 482957022455 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 482957022456 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 482957022457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022459 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957022460 putative effector binding pocket; other site 482957022461 dimerization interface [polypeptide binding]; other site 482957022462 PAAR motif; Region: PAAR_motif; pfam05488 482957022463 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 482957022464 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 482957022465 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 482957022466 putative active site [active] 482957022467 putative active site [active] 482957022468 catalytic site [active] 482957022469 catalytic site [active] 482957022470 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 482957022471 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 482957022472 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 482957022473 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 482957022474 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 482957022475 DNA polymerase II; Reviewed; Region: PRK05762 482957022476 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 482957022477 active site 482957022478 catalytic site [active] 482957022479 substrate binding site [chemical binding]; other site 482957022480 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 482957022481 active site 482957022482 metal-binding site 482957022483 DnaJ domain; Region: DnaJ; pfam00226 482957022484 HSP70 interaction site [polypeptide binding]; other site 482957022485 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 482957022486 Pectinacetylesterase; Region: PAE; pfam03283 482957022487 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 482957022488 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 482957022489 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 482957022490 dimer interface [polypeptide binding]; other site 482957022491 active site 482957022492 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 482957022493 substrate binding site [chemical binding]; other site 482957022494 catalytic residue [active] 482957022495 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 482957022496 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 482957022497 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022498 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022499 trimer interface [polypeptide binding]; other site 482957022500 eyelet of channel; other site 482957022501 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 482957022502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957022503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022504 allantoate amidohydrolase; Reviewed; Region: PRK12890 482957022505 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 482957022506 active site 482957022507 metal binding site [ion binding]; metal-binding site 482957022508 dimer interface [polypeptide binding]; other site 482957022509 allantoinase; Provisional; Region: PRK06189 482957022510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 482957022511 active site 482957022512 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 482957022513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022514 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 482957022515 putative dimerization interface [polypeptide binding]; other site 482957022516 Protein of unknown function (DUF917); Region: DUF917; pfam06032 482957022517 urocanate hydratase; Provisional; Region: PRK05414 482957022518 metabolite-proton symporter; Region: 2A0106; TIGR00883 482957022519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022520 putative substrate translocation pore; other site 482957022521 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 482957022522 active sites [active] 482957022523 tetramer interface [polypeptide binding]; other site 482957022524 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022525 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022526 trimer interface [polypeptide binding]; other site 482957022527 eyelet of channel; other site 482957022528 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022529 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022530 trimer interface [polypeptide binding]; other site 482957022531 eyelet of channel; other site 482957022532 Transcriptional regulators [Transcription]; Region: GntR; COG1802 482957022533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957022534 DNA-binding site [nucleotide binding]; DNA binding site 482957022535 FCD domain; Region: FCD; pfam07729 482957022536 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 482957022537 homodimer interface [polypeptide binding]; other site 482957022538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957022539 catalytic residue [active] 482957022540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022541 D-galactonate transporter; Region: 2A0114; TIGR00893 482957022542 putative substrate translocation pore; other site 482957022543 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 482957022544 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 482957022545 FAD binding domain; Region: FAD_binding_4; pfam01565 482957022546 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 482957022547 Cysteine-rich domain; Region: CCG; pfam02754 482957022548 BON domain; Region: BON; pfam04972 482957022549 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022550 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022551 trimer interface [polypeptide binding]; other site 482957022552 eyelet of channel; other site 482957022553 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142 482957022554 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 482957022555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022556 putative substrate translocation pore; other site 482957022557 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 482957022558 CoA-transferase family III; Region: CoA_transf_3; pfam02515 482957022559 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 482957022560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957022562 dimerization interface [polypeptide binding]; other site 482957022563 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 482957022564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022566 dimerization interface [polypeptide binding]; other site 482957022567 Protein of unknown function, DUF606; Region: DUF606; pfam04657 482957022568 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 482957022569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022570 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 482957022571 substrate binding pocket [chemical binding]; other site 482957022572 dimerization interface [polypeptide binding]; other site 482957022573 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 482957022574 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 482957022575 active site 482957022576 short chain dehydrogenase; Provisional; Region: PRK06172 482957022577 classical (c) SDRs; Region: SDR_c; cd05233 482957022578 NAD(P) binding site [chemical binding]; other site 482957022579 active site 482957022580 short chain dehydrogenase; Provisional; Region: PRK07035 482957022581 classical (c) SDRs; Region: SDR_c; cd05233 482957022582 NAD(P) binding site [chemical binding]; other site 482957022583 active site 482957022584 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 482957022585 Phosphotransferase enzyme family; Region: APH; pfam01636 482957022586 putative active site [active] 482957022587 putative substrate binding site [chemical binding]; other site 482957022588 ATP binding site [chemical binding]; other site 482957022589 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 482957022590 catalytic core [active] 482957022591 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 482957022592 CoenzymeA binding site [chemical binding]; other site 482957022593 subunit interaction site [polypeptide binding]; other site 482957022594 PHB binding site; other site 482957022595 BON domain; Region: BON; pfam04972 482957022596 transcriptional regulator; Provisional; Region: PRK10632 482957022597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022598 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957022599 putative effector binding pocket; other site 482957022600 dimerization interface [polypeptide binding]; other site 482957022601 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 482957022602 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 482957022603 NAD(P) binding site [chemical binding]; other site 482957022604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022607 dimerization interface [polypeptide binding]; other site 482957022608 AAA domain; Region: AAA_22; pfam13401 482957022609 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 482957022610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 482957022611 DNA binding residues [nucleotide binding] 482957022612 dimerization interface [polypeptide binding]; other site 482957022613 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 482957022614 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 482957022615 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957022616 acyl-activating enzyme (AAE) consensus motif; other site 482957022617 AMP binding site [chemical binding]; other site 482957022618 active site 482957022619 CoA binding site [chemical binding]; other site 482957022620 chaperone protein HchA; Provisional; Region: PRK04155 482957022621 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 482957022622 conserved cys residue [active] 482957022623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 482957022624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 482957022625 active site 482957022626 phosphorylation site [posttranslational modification] 482957022627 intermolecular recognition site; other site 482957022628 dimerization interface [polypeptide binding]; other site 482957022629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 482957022630 DNA binding site [nucleotide binding] 482957022631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 482957022632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 482957022633 dimer interface [polypeptide binding]; other site 482957022634 phosphorylation site [posttranslational modification] 482957022635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 482957022636 Mg2+ binding site [ion binding]; other site 482957022637 G-X-G motif; other site 482957022638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022639 D-galactonate transporter; Region: 2A0114; TIGR00893 482957022640 putative substrate translocation pore; other site 482957022641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022644 dimerization interface [polypeptide binding]; other site 482957022645 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 482957022646 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 482957022647 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 482957022648 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 482957022649 putative active site pocket [active] 482957022650 putative metal binding site [ion binding]; other site 482957022651 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 482957022652 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 482957022653 inhibitor site; inhibition site 482957022654 active site 482957022655 dimer interface [polypeptide binding]; other site 482957022656 catalytic residue [active] 482957022657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022658 D-galactonate transporter; Region: 2A0114; TIGR00893 482957022659 putative substrate translocation pore; other site 482957022660 Uncharacterized conserved protein [Function unknown]; Region: COG3391 482957022661 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 482957022662 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 482957022663 Amidohydrolase; Region: Amidohydro_2; pfam04909 482957022664 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 482957022665 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957022666 Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120 482957022667 NAD(P) binding site [chemical binding]; other site 482957022668 catalytic residues [active] 482957022669 choline dehydrogenase; Validated; Region: PRK02106 482957022670 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957022671 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022673 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 482957022674 putative effector binding pocket; other site 482957022675 dimerization interface [polypeptide binding]; other site 482957022676 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 482957022677 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 482957022678 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 482957022679 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 482957022680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 482957022681 dimer interface [polypeptide binding]; other site 482957022682 conserved gate region; other site 482957022683 putative PBP binding loops; other site 482957022684 ABC-ATPase subunit interface; other site 482957022685 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 482957022686 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 482957022687 inhibitor binding site; inhibition site 482957022688 catalytic Zn binding site [ion binding]; other site 482957022689 structural Zn binding site [ion binding]; other site 482957022690 NADP binding site [chemical binding]; other site 482957022691 tetramer interface [polypeptide binding]; other site 482957022692 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 482957022693 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 482957022694 Walker A/P-loop; other site 482957022695 ATP binding site [chemical binding]; other site 482957022696 Q-loop/lid; other site 482957022697 ABC transporter signature motif; other site 482957022698 Walker B; other site 482957022699 D-loop; other site 482957022700 H-loop/switch region; other site 482957022701 Cupin domain; Region: Cupin_2; cl17218 482957022702 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 482957022703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022704 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 482957022705 N- and C-terminal domain interface [polypeptide binding]; other site 482957022706 active site 482957022707 MgATP binding site [chemical binding]; other site 482957022708 catalytic site [active] 482957022709 metal binding site [ion binding]; metal-binding site 482957022710 xylulose binding site [chemical binding]; other site 482957022711 homodimer interface [polypeptide binding]; other site 482957022712 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 482957022713 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 482957022714 DNA binding residues [nucleotide binding] 482957022715 dimer interface [polypeptide binding]; other site 482957022716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957022717 non-specific DNA binding site [nucleotide binding]; other site 482957022718 salt bridge; other site 482957022719 sequence-specific DNA binding site [nucleotide binding]; other site 482957022720 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 482957022721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957022722 DNA-binding site [nucleotide binding]; DNA binding site 482957022723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 482957022724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957022725 homodimer interface [polypeptide binding]; other site 482957022726 catalytic residue [active] 482957022727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957022728 Coenzyme A binding pocket [chemical binding]; other site 482957022729 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 482957022730 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 482957022731 Esterase/lipase [General function prediction only]; Region: COG1647 482957022732 MASE1; Region: MASE1; pfam05231 482957022733 PAS fold; Region: PAS_3; pfam08447 482957022734 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 482957022735 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022736 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022737 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022738 dimerization interface [polypeptide binding]; other site 482957022739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 482957022740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957022741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 482957022742 Coenzyme A binding pocket [chemical binding]; other site 482957022743 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 482957022744 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 482957022745 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 482957022746 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 482957022747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 482957022748 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 482957022749 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 482957022750 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 482957022751 putative active site [active] 482957022752 putative metal binding site [ion binding]; other site 482957022753 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 482957022754 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957022755 substrate binding pocket [chemical binding]; other site 482957022756 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957022757 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 482957022758 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 482957022759 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 482957022760 Metal-binding active site; metal-binding site 482957022761 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 482957022762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957022763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957022764 Indoleamine 2,3-dioxygenase; Region: IDO; pfam01231 482957022765 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 482957022766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957022767 NAD(P) binding site [chemical binding]; other site 482957022768 active site 482957022769 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 482957022770 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 482957022771 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 482957022772 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 482957022773 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 482957022774 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 482957022775 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 482957022776 dimer interface [polypeptide binding]; other site 482957022777 active site 482957022778 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 482957022779 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 482957022780 active site 482957022781 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 482957022782 hypothetical protein; Provisional; Region: PRK07236 482957022783 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 482957022784 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 482957022785 Zn binding site [ion binding]; other site 482957022786 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 482957022787 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 482957022788 acyl-activating enzyme (AAE) consensus motif; other site 482957022789 AMP binding site [chemical binding]; other site 482957022790 active site 482957022791 CoA binding site [chemical binding]; other site 482957022792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957022793 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 482957022794 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 482957022795 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957022796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022797 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 482957022798 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 482957022799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022800 disulfide bond formation protein B; Provisional; Region: PRK02110 482957022801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022803 dimerization interface [polypeptide binding]; other site 482957022804 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 482957022805 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022806 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022807 trimer interface [polypeptide binding]; other site 482957022808 eyelet of channel; other site 482957022809 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 482957022810 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 482957022811 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022813 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 482957022814 putative substrate binding pocket [chemical binding]; other site 482957022815 putative dimerization interface [polypeptide binding]; other site 482957022816 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 482957022817 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957022818 homotrimer interaction site [polypeptide binding]; other site 482957022819 putative active site [active] 482957022820 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957022821 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 482957022822 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 482957022823 benzoate transport; Region: 2A0115; TIGR00895 482957022824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022825 putative substrate translocation pore; other site 482957022826 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 482957022827 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 482957022828 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 482957022829 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 482957022830 tetramer interface [polypeptide binding]; other site 482957022831 active site 482957022832 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 482957022833 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 482957022834 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 482957022835 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 482957022836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022838 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 482957022839 substrate binding pocket [chemical binding]; other site 482957022840 dimerization interface [polypeptide binding]; other site 482957022841 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 482957022842 GTP cyclohydrolase I; Provisional; Region: PLN03044 482957022843 active site 482957022844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 482957022845 short chain dehydrogenase; Provisional; Region: PRK09134 482957022846 NAD(P) binding site [chemical binding]; other site 482957022847 active site 482957022848 serine O-acetyltransferase; Region: cysE; TIGR01172 482957022849 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 482957022850 trimer interface [polypeptide binding]; other site 482957022851 active site 482957022852 substrate binding site [chemical binding]; other site 482957022853 CoA binding site [chemical binding]; other site 482957022854 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 482957022855 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 482957022856 Ligand Binding Site [chemical binding]; other site 482957022857 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 482957022858 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 482957022859 ligand binding site [chemical binding]; other site 482957022860 flexible hinge region; other site 482957022861 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 482957022862 putative switch regulator; other site 482957022863 non-specific DNA interactions [nucleotide binding]; other site 482957022864 DNA binding site [nucleotide binding] 482957022865 sequence specific DNA binding site [nucleotide binding]; other site 482957022866 putative cAMP binding site [chemical binding]; other site 482957022867 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 482957022868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 482957022870 dimerization interface [polypeptide binding]; other site 482957022871 Lysine efflux permease [General function prediction only]; Region: COG1279 482957022872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 482957022873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 482957022874 active site 482957022875 catalytic tetrad [active] 482957022876 Helix-turn-helix domain; Region: HTH_18; pfam12833 482957022877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022878 choline dehydrogenase; Validated; Region: PRK02106 482957022879 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 482957022880 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957022881 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957022882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022883 Cupin domain; Region: Cupin_2; pfam07883 482957022884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022885 D-galactonate transporter; Region: 2A0114; TIGR00893 482957022886 putative substrate translocation pore; other site 482957022887 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 482957022888 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 482957022889 putative NAD(P) binding site [chemical binding]; other site 482957022890 catalytic Zn binding site [ion binding]; other site 482957022891 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 482957022892 classical (c) SDRs; Region: SDR_c; cd05233 482957022893 NAD(P) binding site [chemical binding]; other site 482957022894 active site 482957022895 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022896 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022897 trimer interface [polypeptide binding]; other site 482957022898 eyelet of channel; other site 482957022899 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 482957022900 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 482957022901 trimer interface [polypeptide binding]; other site 482957022902 eyelet of channel; other site 482957022903 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 482957022904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 482957022905 DNA-binding site [nucleotide binding]; DNA binding site 482957022906 FCD domain; Region: FCD; pfam07729 482957022907 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 482957022908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 482957022909 putative substrate translocation pore; other site 482957022910 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 482957022911 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 482957022912 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 482957022913 homotrimer interaction site [polypeptide binding]; other site 482957022914 putative active site [active] 482957022915 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 482957022916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 482957022917 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 482957022918 choline dehydrogenase; Validated; Region: PRK02106 482957022919 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 482957022920 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 482957022921 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 482957022922 NAD(P) binding site [chemical binding]; other site 482957022923 catalytic residues [active] 482957022924 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 482957022925 Catalytic domain of Protein Kinases; Region: PKc; cd00180 482957022926 active site 482957022927 ATP binding site [chemical binding]; other site 482957022928 substrate binding site [chemical binding]; other site 482957022929 activation loop (A-loop); other site 482957022930 cyclase homology domain; Region: CHD; cd07302 482957022931 dimer interface [polypeptide binding]; other site 482957022932 nucleotidyl binding site; other site 482957022933 metal binding site [ion binding]; metal-binding site 482957022934 AAA ATPase domain; Region: AAA_16; pfam13191 482957022935 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 482957022936 phosphopeptide binding site; other site 482957022937 Predicted transcriptional regulators [Transcription]; Region: COG1695 482957022938 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 482957022939 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 482957022940 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 482957022941 FAD binding pocket [chemical binding]; other site 482957022942 FAD binding motif [chemical binding]; other site 482957022943 phosphate binding motif [ion binding]; other site 482957022944 NAD binding pocket [chemical binding]; other site 482957022945 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 482957022946 active site 482957022947 acetoacetate decarboxylase; Provisional; Region: PRK02265 482957022948 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 482957022949 classical (c) SDRs; Region: SDR_c; cd05233 482957022950 NAD(P) binding site [chemical binding]; other site 482957022951 active site 482957022952 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 482957022953 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 482957022954 nucleophile elbow; other site 482957022955 Patatin phospholipase; Region: DUF3734; pfam12536 482957022956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 482957022957 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022958 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 482957022959 dimerization interface [polypeptide binding]; other site 482957022960 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 482957022961 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 482957022962 transcriptional activator TtdR; Provisional; Region: PRK09801 482957022963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 482957022964 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 482957022965 putative effector binding pocket; other site 482957022966 putative dimerization interface [polypeptide binding]; other site 482957022967 tartrate dehydrogenase; Region: TTC; TIGR02089 482957022968 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 482957022969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 482957022970 SnoaL-like domain; Region: SnoaL_2; pfam12680 482957022971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 482957022972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 482957022973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 482957022974 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 482957022975 Coenzyme A binding pocket [chemical binding]; other site 482957022976 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 482957022977 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 482957022978 NAD(P) binding site [chemical binding]; other site 482957022979 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 482957022980 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 482957022981 substrate-cofactor binding pocket; other site 482957022982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 482957022983 catalytic residue [active] 482957022984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 482957022985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 482957022986 non-specific DNA binding site [nucleotide binding]; other site 482957022987 salt bridge; other site 482957022988 sequence-specific DNA binding site [nucleotide binding]; other site 482957022989 Cupin domain; Region: Cupin_2; pfam07883 482957022990 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616