-- dump date 20140619_015456 -- class Genbank::misc_feature -- table misc_feature_note -- id note 758793000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 758793000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 758793000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793000004 Walker A motif; other site 758793000005 ATP binding site [chemical binding]; other site 758793000006 Walker B motif; other site 758793000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758793000008 arginine finger; other site 758793000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 758793000010 DnaA box-binding interface [nucleotide binding]; other site 758793000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 758793000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 758793000013 putative DNA binding surface [nucleotide binding]; other site 758793000014 dimer interface [polypeptide binding]; other site 758793000015 beta-clamp/clamp loader binding surface; other site 758793000016 beta-clamp/translesion DNA polymerase binding surface; other site 758793000017 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 758793000018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793000019 ATP binding site [chemical binding]; other site 758793000020 Mg2+ binding site [ion binding]; other site 758793000021 G-X-G motif; other site 758793000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 758793000023 anchoring element; other site 758793000024 dimer interface [polypeptide binding]; other site 758793000025 ATP binding site [chemical binding]; other site 758793000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 758793000027 active site 758793000028 putative metal-binding site [ion binding]; other site 758793000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 758793000030 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 758793000031 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 758793000032 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 758793000033 Peptidase M15; Region: Peptidase_M15_3; cl01194 758793000034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793000035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793000036 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 758793000037 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 758793000038 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758793000039 ATP binding site [chemical binding]; other site 758793000040 Mg++ binding site [ion binding]; other site 758793000041 motif III; other site 758793000042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793000043 nucleotide binding region [chemical binding]; other site 758793000044 ATP-binding site [chemical binding]; other site 758793000045 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 758793000046 putative RNA binding site [nucleotide binding]; other site 758793000047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793000048 putative substrate translocation pore; other site 758793000049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793000050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793000051 Protein of unknown function, DUF488; Region: DUF488; cl01246 758793000052 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 758793000053 CoenzymeA binding site [chemical binding]; other site 758793000054 subunit interaction site [polypeptide binding]; other site 758793000055 PHB binding site; other site 758793000056 Patatin-like phospholipase; Region: Patatin; pfam01734 758793000057 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 758793000058 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 758793000059 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 758793000060 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 758793000061 dimerization interface [polypeptide binding]; other site 758793000062 NAD binding site [chemical binding]; other site 758793000063 ligand binding site [chemical binding]; other site 758793000064 catalytic site [active] 758793000065 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 758793000066 active site 758793000067 substrate-binding site [chemical binding]; other site 758793000068 metal-binding site [ion binding] 758793000069 GTP binding site [chemical binding]; other site 758793000070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793000071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793000072 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793000073 putative effector binding pocket; other site 758793000074 dimerization interface [polypeptide binding]; other site 758793000075 DNA topoisomerase III; Validated; Region: PRK08173 758793000076 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 758793000077 active site 758793000078 putative interdomain interaction site [polypeptide binding]; other site 758793000079 putative metal-binding site [ion binding]; other site 758793000080 putative nucleotide binding site [chemical binding]; other site 758793000081 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 758793000082 domain I; other site 758793000083 DNA binding groove [nucleotide binding] 758793000084 phosphate binding site [ion binding]; other site 758793000085 domain II; other site 758793000086 domain III; other site 758793000087 nucleotide binding site [chemical binding]; other site 758793000088 catalytic site [active] 758793000089 domain IV; other site 758793000090 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 758793000091 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 758793000092 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758793000093 catalytic residues [active] 758793000094 DNA protecting protein DprA; Region: dprA; TIGR00732 758793000095 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 758793000096 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 758793000097 active site 758793000098 catalytic residues [active] 758793000099 metal binding site [ion binding]; metal-binding site 758793000100 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 758793000101 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 758793000102 putative active site [active] 758793000103 substrate binding site [chemical binding]; other site 758793000104 putative cosubstrate binding site; other site 758793000105 catalytic site [active] 758793000106 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 758793000107 substrate binding site [chemical binding]; other site 758793000108 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793000109 M48 family peptidase; Provisional; Region: PRK03001 758793000110 16S rRNA methyltransferase B; Provisional; Region: PRK10901 758793000111 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 758793000112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793000113 S-adenosylmethionine binding site [chemical binding]; other site 758793000114 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 758793000115 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 758793000116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793000117 dimerization interface [polypeptide binding]; other site 758793000118 PAS domain; Region: PAS; smart00091 758793000119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793000120 dimer interface [polypeptide binding]; other site 758793000121 phosphorylation site [posttranslational modification] 758793000122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793000123 ATP binding site [chemical binding]; other site 758793000124 Mg2+ binding site [ion binding]; other site 758793000125 G-X-G motif; other site 758793000126 Response regulator receiver domain; Region: Response_reg; pfam00072 758793000127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000128 active site 758793000129 phosphorylation site [posttranslational modification] 758793000130 intermolecular recognition site; other site 758793000131 dimerization interface [polypeptide binding]; other site 758793000132 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 758793000133 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 758793000134 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 758793000135 Ligand Binding Site [chemical binding]; other site 758793000136 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 758793000137 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 758793000138 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 758793000139 active site 758793000140 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 758793000141 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 758793000142 Sel1-like repeats; Region: SEL1; smart00671 758793000143 Sel1-like repeats; Region: SEL1; smart00671 758793000144 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 758793000145 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 758793000146 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 758793000147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 758793000148 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 758793000149 rod shape-determining protein MreC; Provisional; Region: PRK13922 758793000150 rod shape-determining protein MreC; Region: MreC; pfam04085 758793000151 rod shape-determining protein MreB; Provisional; Region: PRK13927 758793000152 MreB and similar proteins; Region: MreB_like; cd10225 758793000153 nucleotide binding site [chemical binding]; other site 758793000154 Mg binding site [ion binding]; other site 758793000155 putative protofilament interaction site [polypeptide binding]; other site 758793000156 RodZ interaction site [polypeptide binding]; other site 758793000157 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 758793000158 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 758793000159 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 758793000160 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 758793000161 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 758793000162 GatB domain; Region: GatB_Yqey; smart00845 758793000163 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 758793000164 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 758793000165 putative active site [active] 758793000166 putative catalytic site [active] 758793000167 putative DNA binding site [nucleotide binding]; other site 758793000168 putative phosphate binding site [ion binding]; other site 758793000169 metal binding site A [ion binding]; metal-binding site 758793000170 putative AP binding site [nucleotide binding]; other site 758793000171 putative metal binding site B [ion binding]; other site 758793000172 Peptidase family M48; Region: Peptidase_M48; cl12018 758793000173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793000174 muropeptide transporter; Reviewed; Region: ampG; PRK11902 758793000175 putative substrate translocation pore; other site 758793000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793000177 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 758793000178 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 758793000179 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 758793000180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 758793000181 motif II; other site 758793000182 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 758793000183 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 758793000184 feedback inhibition sensing region; other site 758793000185 homohexameric interface [polypeptide binding]; other site 758793000186 nucleotide binding site [chemical binding]; other site 758793000187 N-acetyl-L-glutamate binding site [chemical binding]; other site 758793000188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793000189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 758793000190 dimer interface [polypeptide binding]; other site 758793000191 phosphorylation site [posttranslational modification] 758793000192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793000193 ATP binding site [chemical binding]; other site 758793000194 Mg2+ binding site [ion binding]; other site 758793000195 G-X-G motif; other site 758793000196 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 758793000197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000198 active site 758793000199 phosphorylation site [posttranslational modification] 758793000200 intermolecular recognition site; other site 758793000201 dimerization interface [polypeptide binding]; other site 758793000202 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793000203 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758793000204 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793000205 dimer interface [polypeptide binding]; other site 758793000206 putative CheW interface [polypeptide binding]; other site 758793000207 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 758793000208 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 758793000209 trimer interface [polypeptide binding]; other site 758793000210 YadA-like C-terminal region; Region: YadA; pfam03895 758793000211 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 758793000212 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793000213 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 758793000214 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 758793000215 dimer interface [polypeptide binding]; other site 758793000216 PYR/PP interface [polypeptide binding]; other site 758793000217 TPP binding site [chemical binding]; other site 758793000218 substrate binding site [chemical binding]; other site 758793000219 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 758793000220 TPP-binding site [chemical binding]; other site 758793000221 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 758793000222 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793000223 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 758793000224 putative C-terminal domain interface [polypeptide binding]; other site 758793000225 putative GSH binding site (G-site) [chemical binding]; other site 758793000226 putative dimer interface [polypeptide binding]; other site 758793000227 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 758793000228 dimer interface [polypeptide binding]; other site 758793000229 N-terminal domain interface [polypeptide binding]; other site 758793000230 putative substrate binding pocket (H-site) [chemical binding]; other site 758793000231 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 758793000232 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793000233 putative substrate binding site [chemical binding]; other site 758793000234 putative ATP binding site [chemical binding]; other site 758793000235 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 758793000236 dimerization interface [polypeptide binding]; other site 758793000237 putative active cleft [active] 758793000238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793000239 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793000240 DNA binding site [nucleotide binding] 758793000241 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 758793000242 ligand binding site [chemical binding]; other site 758793000243 dimerization interface [polypeptide binding]; other site 758793000244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793000245 S-adenosylmethionine binding site [chemical binding]; other site 758793000246 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 758793000247 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793000248 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 758793000249 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 758793000250 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793000251 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793000252 eyelet of channel; other site 758793000253 trimer interface [polypeptide binding]; other site 758793000254 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 758793000255 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 758793000256 FMN binding site [chemical binding]; other site 758793000257 substrate binding site [chemical binding]; other site 758793000258 putative catalytic residue [active] 758793000259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793000260 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793000261 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 758793000262 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 758793000263 active site 758793000264 catalytic site [active] 758793000265 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 758793000266 putative deacylase active site [active] 758793000267 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 758793000268 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 758793000269 active site 758793000270 catalytic residues [active] 758793000271 metal binding site [ion binding]; metal-binding site 758793000272 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 758793000273 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 758793000274 putative ligand binding site [chemical binding]; other site 758793000275 NAD binding site [chemical binding]; other site 758793000276 dimerization interface [polypeptide binding]; other site 758793000277 catalytic site [active] 758793000278 biotin synthase; Region: bioB; TIGR00433 758793000279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793000280 FeS/SAM binding site; other site 758793000281 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 758793000282 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 758793000283 AAA domain; Region: AAA_26; pfam13500 758793000284 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 758793000285 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 758793000286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793000287 catalytic residue [active] 758793000288 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 758793000289 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793000290 inhibitor-cofactor binding pocket; inhibition site 758793000291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793000292 catalytic residue [active] 758793000293 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 758793000294 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793000295 hypothetical protein; Provisional; Region: PRK01842 758793000296 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 758793000297 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793000298 putative C-terminal domain interface [polypeptide binding]; other site 758793000299 putative GSH binding site (G-site) [chemical binding]; other site 758793000300 putative dimer interface [polypeptide binding]; other site 758793000301 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793000302 N-terminal domain interface [polypeptide binding]; other site 758793000303 dimer interface [polypeptide binding]; other site 758793000304 substrate binding pocket (H-site) [chemical binding]; other site 758793000305 C factor cell-cell signaling protein; Provisional; Region: PRK09009 758793000306 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 758793000307 NADP binding site [chemical binding]; other site 758793000308 homodimer interface [polypeptide binding]; other site 758793000309 active site 758793000310 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 758793000311 oligomeric interface; other site 758793000312 homodimer interface [polypeptide binding]; other site 758793000313 putative active site [active] 758793000314 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 758793000315 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793000316 dimer interface [polypeptide binding]; other site 758793000317 active site 758793000318 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 758793000319 active site clefts [active] 758793000320 zinc binding site [ion binding]; other site 758793000321 dimer interface [polypeptide binding]; other site 758793000322 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 758793000323 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 758793000324 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 758793000325 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758793000326 DNA binding residues [nucleotide binding] 758793000327 putative dimer interface [polypeptide binding]; other site 758793000328 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 758793000329 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793000330 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 758793000331 peptide binding site [polypeptide binding]; other site 758793000332 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 758793000333 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 758793000334 Flagellar protein FliT; Region: FliT; cl05125 758793000335 flagellar capping protein; Reviewed; Region: fliD; PRK08032 758793000336 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 758793000337 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 758793000338 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 758793000339 flagellin; Reviewed; Region: PRK08869 758793000340 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 758793000341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793000342 Tetratricopeptide repeat; Region: TPR_16; pfam13432 758793000343 TPR motif; other site 758793000344 binding surface 758793000345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793000346 TPR motif; other site 758793000347 TPR repeat; Region: TPR_11; pfam13414 758793000348 binding surface 758793000349 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793000350 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793000351 active site 758793000352 catalytic tetrad [active] 758793000353 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 758793000354 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 758793000355 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 758793000356 putative hydrolase; Provisional; Region: PRK10976 758793000357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793000358 active site 758793000359 motif I; other site 758793000360 motif II; other site 758793000361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793000362 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 758793000363 amphipathic channel; other site 758793000364 Asn-Pro-Ala signature motifs; other site 758793000365 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 758793000366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793000367 putative ADP-binding pocket [chemical binding]; other site 758793000368 transcriptional activator FlhD; Provisional; Region: PRK02909 758793000369 transcriptional activator FlhC; Provisional; Region: PRK12722 758793000370 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 758793000371 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 758793000372 flagellar motor protein MotA; Validated; Region: PRK09110 758793000373 flagellar motor protein MotB; Validated; Region: motB; PRK09041 758793000374 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 758793000375 Protein of unknown function, DUF484; Region: DUF484; cl17449 758793000376 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793000377 ligand binding site [chemical binding]; other site 758793000378 Response regulator receiver domain; Region: Response_reg; pfam00072 758793000379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000380 active site 758793000381 phosphorylation site [posttranslational modification] 758793000382 intermolecular recognition site; other site 758793000383 dimerization interface [polypeptide binding]; other site 758793000384 chemotaxis protein CheA; Provisional; Region: PRK10547 758793000385 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 758793000386 putative binding surface; other site 758793000387 active site 758793000388 CheY binding; Region: CheY-binding; pfam09078 758793000389 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 758793000390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793000391 ATP binding site [chemical binding]; other site 758793000392 Mg2+ binding site [ion binding]; other site 758793000393 G-X-G motif; other site 758793000394 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 758793000395 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 758793000396 putative CheA interaction surface; other site 758793000397 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 758793000398 dimer interface [polypeptide binding]; other site 758793000399 ligand binding site [chemical binding]; other site 758793000400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793000401 dimerization interface [polypeptide binding]; other site 758793000402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793000403 dimer interface [polypeptide binding]; other site 758793000404 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 758793000405 putative CheW interface [polypeptide binding]; other site 758793000406 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 758793000407 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 758793000408 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 758793000409 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 758793000410 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 758793000411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000412 active site 758793000413 phosphorylation site [posttranslational modification] 758793000414 intermolecular recognition site; other site 758793000415 dimerization interface [polypeptide binding]; other site 758793000416 CheB methylesterase; Region: CheB_methylest; pfam01339 758793000417 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 758793000418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000419 active site 758793000420 phosphorylation site [posttranslational modification] 758793000421 intermolecular recognition site; other site 758793000422 dimerization interface [polypeptide binding]; other site 758793000423 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 758793000424 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 758793000425 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 758793000426 short chain dehydrogenase; Provisional; Region: PRK07024 758793000427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793000428 NAD(P) binding site [chemical binding]; other site 758793000429 active site 758793000430 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 758793000431 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 758793000432 catalytic residues [active] 758793000433 hinge region; other site 758793000434 alpha helical domain; other site 758793000435 Sporulation related domain; Region: SPOR; pfam05036 758793000436 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 758793000437 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 758793000438 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 758793000439 active site 758793000440 HIGH motif; other site 758793000441 KMSK motif region; other site 758793000442 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 758793000443 tRNA binding surface [nucleotide binding]; other site 758793000444 anticodon binding site; other site 758793000445 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 758793000446 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 758793000447 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 758793000448 substrate binding pocket [chemical binding]; other site 758793000449 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 758793000450 B12 binding site [chemical binding]; other site 758793000451 cobalt ligand [ion binding]; other site 758793000452 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 758793000453 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 758793000454 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 758793000455 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 758793000456 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 758793000457 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 758793000458 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793000459 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793000460 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 758793000461 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793000462 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793000463 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 758793000464 putative ligand binding site [chemical binding]; other site 758793000465 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 758793000466 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793000467 substrate binding site [chemical binding]; other site 758793000468 oxyanion hole (OAH) forming residues; other site 758793000469 trimer interface [polypeptide binding]; other site 758793000470 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 758793000471 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758793000472 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 758793000473 DNA binding residues [nucleotide binding] 758793000474 B12 binding domain; Region: B12-binding_2; pfam02607 758793000475 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 758793000476 B12 binding site [chemical binding]; other site 758793000477 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 758793000478 dinuclear metal binding motif [ion binding]; other site 758793000479 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 758793000480 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 758793000481 active site 758793000482 nucleotide binding site [chemical binding]; other site 758793000483 HIGH motif; other site 758793000484 KMSKS motif; other site 758793000485 pantothenate kinase; Reviewed; Region: PRK13328 758793000486 biotin--protein ligase; Provisional; Region: PRK06955 758793000487 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 758793000488 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 758793000489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758793000490 non-specific DNA binding site [nucleotide binding]; other site 758793000491 salt bridge; other site 758793000492 sequence-specific DNA binding site [nucleotide binding]; other site 758793000493 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 758793000494 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 758793000495 Permease; Region: Permease; pfam02405 758793000496 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 758793000497 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 758793000498 Walker A/P-loop; other site 758793000499 ATP binding site [chemical binding]; other site 758793000500 Q-loop/lid; other site 758793000501 ABC transporter signature motif; other site 758793000502 Walker B; other site 758793000503 D-loop; other site 758793000504 H-loop/switch region; other site 758793000505 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 758793000506 mce related protein; Region: MCE; pfam02470 758793000507 Protein of unknown function (DUF330); Region: DUF330; cl01135 758793000508 Predicted integral membrane protein [Function unknown]; Region: COG5652 758793000509 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 758793000510 dimer interface [polypeptide binding]; other site 758793000511 [2Fe-2S] cluster binding site [ion binding]; other site 758793000512 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 758793000513 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 758793000514 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 758793000515 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 758793000516 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 758793000517 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 758793000518 homodimer interface [polypeptide binding]; other site 758793000519 substrate-cofactor binding pocket; other site 758793000520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793000521 catalytic residue [active] 758793000522 Protein of unknown function (DUF493); Region: DUF493; cl01102 758793000523 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793000524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793000525 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793000526 dimerization interface [polypeptide binding]; other site 758793000527 substrate binding pocket [chemical binding]; other site 758793000528 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 758793000529 lipoate-protein ligase B; Provisional; Region: PRK14343 758793000530 lipoyl synthase; Provisional; Region: PRK05481 758793000531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793000532 FeS/SAM binding site; other site 758793000533 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 758793000534 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758793000535 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 758793000536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793000537 dimer interface [polypeptide binding]; other site 758793000538 phosphorylation site [posttranslational modification] 758793000539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793000540 ATP binding site [chemical binding]; other site 758793000541 Mg2+ binding site [ion binding]; other site 758793000542 G-X-G motif; other site 758793000543 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 758793000544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000545 active site 758793000546 phosphorylation site [posttranslational modification] 758793000547 intermolecular recognition site; other site 758793000548 dimerization interface [polypeptide binding]; other site 758793000549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793000550 Walker A motif; other site 758793000551 ATP binding site [chemical binding]; other site 758793000552 Walker B motif; other site 758793000553 arginine finger; other site 758793000554 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793000555 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 758793000556 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793000557 catalytic residues [active] 758793000558 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 758793000559 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 758793000560 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 758793000561 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 758793000562 Membrane fusogenic activity; Region: BMFP; pfam04380 758793000563 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 758793000564 Nitrogen regulatory protein P-II; Region: P-II; smart00938 758793000565 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 758793000566 Glutamate-cysteine ligase; Region: GshA; pfam08886 758793000567 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 758793000568 glutathione synthetase; Provisional; Region: PRK05246 758793000569 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 758793000570 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 758793000571 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 758793000572 active pocket/dimerization site; other site 758793000573 active site 758793000574 phosphorylation site [posttranslational modification] 758793000575 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 758793000576 dimerization domain swap beta strand [polypeptide binding]; other site 758793000577 regulatory protein interface [polypeptide binding]; other site 758793000578 active site 758793000579 regulatory phosphorylation site [posttranslational modification]; other site 758793000580 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 758793000581 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 758793000582 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 758793000583 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 758793000584 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 758793000585 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 758793000586 ATP binding site [chemical binding]; other site 758793000587 substrate interface [chemical binding]; other site 758793000588 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 758793000589 C-terminal peptidase (prc); Region: prc; TIGR00225 758793000590 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 758793000591 protein binding site [polypeptide binding]; other site 758793000592 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 758793000593 Catalytic dyad [active] 758793000594 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 758793000595 catalytic core [active] 758793000596 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 758793000597 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 758793000598 active site residue [active] 758793000599 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 758793000600 GSH binding site [chemical binding]; other site 758793000601 catalytic residues [active] 758793000602 preprotein translocase subunit SecB; Validated; Region: PRK05751 758793000603 SecA binding site; other site 758793000604 Preprotein binding site; other site 758793000605 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 758793000606 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 758793000607 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 758793000608 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 758793000609 putative ADP-ribose binding site [chemical binding]; other site 758793000610 putative active site [active] 758793000611 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 758793000612 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 758793000613 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793000614 active site 758793000615 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 758793000616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793000617 S-adenosylmethionine binding site [chemical binding]; other site 758793000618 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 758793000619 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 758793000620 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 758793000621 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 758793000622 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793000623 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 758793000624 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793000625 ligand binding site [chemical binding]; other site 758793000626 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 758793000627 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 758793000628 Subunit I/III interface [polypeptide binding]; other site 758793000629 D-pathway; other site 758793000630 Subunit I/VIIc interface [polypeptide binding]; other site 758793000631 Subunit I/IV interface [polypeptide binding]; other site 758793000632 Subunit I/II interface [polypeptide binding]; other site 758793000633 Low-spin heme (heme a) binding site [chemical binding]; other site 758793000634 Subunit I/VIIa interface [polypeptide binding]; other site 758793000635 Subunit I/VIa interface [polypeptide binding]; other site 758793000636 Dimer interface; other site 758793000637 Putative water exit pathway; other site 758793000638 Binuclear center (heme a3/CuB) [ion binding]; other site 758793000639 K-pathway; other site 758793000640 Subunit I/Vb interface [polypeptide binding]; other site 758793000641 Putative proton exit pathway; other site 758793000642 Subunit I/VIb interface; other site 758793000643 Subunit I/VIc interface [polypeptide binding]; other site 758793000644 Electron transfer pathway; other site 758793000645 Subunit I/VIIIb interface [polypeptide binding]; other site 758793000646 Subunit I/VIIb interface [polypeptide binding]; other site 758793000647 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 758793000648 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 758793000649 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 758793000650 Subunit III/VIIa interface [polypeptide binding]; other site 758793000651 Phospholipid binding site [chemical binding]; other site 758793000652 Subunit I/III interface [polypeptide binding]; other site 758793000653 Subunit III/VIb interface [polypeptide binding]; other site 758793000654 Subunit III/VIa interface; other site 758793000655 Subunit III/Vb interface [polypeptide binding]; other site 758793000656 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 758793000657 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 758793000658 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793000659 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 758793000660 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 758793000661 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 758793000662 UbiA prenyltransferase family; Region: UbiA; pfam01040 758793000663 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 758793000664 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 758793000665 Cu(I) binding site [ion binding]; other site 758793000666 YCII-related domain; Region: YCII; cl00999 758793000667 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 758793000668 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 758793000669 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793000670 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793000671 putative DNA binding site [nucleotide binding]; other site 758793000672 putative Zn2+ binding site [ion binding]; other site 758793000673 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758793000674 Coenzyme A binding pocket [chemical binding]; other site 758793000675 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758793000676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793000677 DNA-binding site [nucleotide binding]; DNA binding site 758793000678 UTRA domain; Region: UTRA; pfam07702 758793000679 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 758793000680 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 758793000681 active site 758793000682 dimer interface [polypeptide binding]; other site 758793000683 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 758793000684 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 758793000685 dimer interface [polypeptide binding]; other site 758793000686 active site 758793000687 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 758793000688 dimer interface [polypeptide binding]; other site 758793000689 active site 758793000690 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758793000691 HPr interaction site; other site 758793000692 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758793000693 active site 758793000694 phosphorylation site [posttranslational modification] 758793000695 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 758793000696 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 758793000697 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 758793000698 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 758793000699 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758793000700 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 758793000701 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758793000702 active site turn [active] 758793000703 phosphorylation site [posttranslational modification] 758793000704 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 758793000705 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793000706 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793000707 DNA binding residues [nucleotide binding] 758793000708 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 758793000709 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 758793000710 SnoaL-like domain; Region: SnoaL_3; pfam13474 758793000711 2-isopropylmalate synthase; Validated; Region: PRK03739 758793000712 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 758793000713 active site 758793000714 catalytic residues [active] 758793000715 metal binding site [ion binding]; metal-binding site 758793000716 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 758793000717 glycosyl transferase family protein; Provisional; Region: PRK08136 758793000718 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 758793000719 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 758793000720 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793000721 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 758793000722 maleylacetoacetate isomerase; Region: maiA; TIGR01262 758793000723 C-terminal domain interface [polypeptide binding]; other site 758793000724 GSH binding site (G-site) [chemical binding]; other site 758793000725 putative dimer interface [polypeptide binding]; other site 758793000726 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 758793000727 dimer interface [polypeptide binding]; other site 758793000728 N-terminal domain interface [polypeptide binding]; other site 758793000729 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 758793000730 Lysine efflux permease [General function prediction only]; Region: COG1279 758793000731 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 758793000732 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 758793000733 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793000734 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 758793000735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793000736 S-adenosylmethionine binding site [chemical binding]; other site 758793000737 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 758793000738 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 758793000739 active site 758793000740 (T/H)XGH motif; other site 758793000741 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 758793000742 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 758793000743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793000744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793000745 homodimer interface [polypeptide binding]; other site 758793000746 catalytic residue [active] 758793000747 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 758793000748 putative active site [active] 758793000749 catalytic residue [active] 758793000750 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 758793000751 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 758793000752 5S rRNA interface [nucleotide binding]; other site 758793000753 CTC domain interface [polypeptide binding]; other site 758793000754 L16 interface [polypeptide binding]; other site 758793000755 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 758793000756 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 758793000757 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793000758 active site 758793000759 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 758793000760 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 758793000761 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 758793000762 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 758793000763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793000764 TPR motif; other site 758793000765 binding surface 758793000766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793000767 binding surface 758793000768 TPR motif; other site 758793000769 TPR repeat; Region: TPR_11; pfam13414 758793000770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793000771 binding surface 758793000772 TPR motif; other site 758793000773 TPR repeat; Region: TPR_11; pfam13414 758793000774 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 758793000775 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 758793000776 DNA binding site [nucleotide binding] 758793000777 catalytic residue [active] 758793000778 H2TH interface [polypeptide binding]; other site 758793000779 putative catalytic residues [active] 758793000780 turnover-facilitating residue; other site 758793000781 intercalation triad [nucleotide binding]; other site 758793000782 8OG recognition residue [nucleotide binding]; other site 758793000783 putative reading head residues; other site 758793000784 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 758793000785 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 758793000786 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 758793000787 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 758793000788 minor groove reading motif; other site 758793000789 helix-hairpin-helix signature motif; other site 758793000790 substrate binding pocket [chemical binding]; other site 758793000791 active site 758793000792 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 758793000793 DNA binding and oxoG recognition site [nucleotide binding] 758793000794 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 758793000795 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 758793000796 HPr kinase/phosphorylase; Provisional; Region: PRK05428 758793000797 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 758793000798 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 758793000799 Hpr binding site; other site 758793000800 active site 758793000801 homohexamer subunit interaction site [polypeptide binding]; other site 758793000802 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 758793000803 active site 758793000804 phosphorylation site [posttranslational modification] 758793000805 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 758793000806 30S subunit binding site; other site 758793000807 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 758793000808 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 758793000809 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 758793000810 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 758793000811 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 758793000812 Walker A/P-loop; other site 758793000813 ATP binding site [chemical binding]; other site 758793000814 Q-loop/lid; other site 758793000815 ABC transporter signature motif; other site 758793000816 Walker B; other site 758793000817 D-loop; other site 758793000818 H-loop/switch region; other site 758793000819 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 758793000820 OstA-like protein; Region: OstA; pfam03968 758793000821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 758793000822 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 758793000823 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 758793000824 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 758793000825 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 758793000826 putative active site [active] 758793000827 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 758793000828 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758793000829 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 758793000830 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 758793000831 TrkA-N domain; Region: TrkA_N; pfam02254 758793000832 TrkA-C domain; Region: TrkA_C; pfam02080 758793000833 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793000834 active site 758793000835 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793000836 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 758793000837 nudix motif; other site 758793000838 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 758793000839 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 758793000840 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 758793000841 putative active site [active] 758793000842 putative substrate binding site [chemical binding]; other site 758793000843 putative cosubstrate binding site; other site 758793000844 catalytic site [active] 758793000845 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 758793000846 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 758793000847 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758793000848 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758793000849 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 758793000850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793000851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793000852 putative substrate translocation pore; other site 758793000853 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 758793000854 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 758793000855 dimer interface [polypeptide binding]; other site 758793000856 ssDNA binding site [nucleotide binding]; other site 758793000857 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758793000858 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793000859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000860 active site 758793000861 phosphorylation site [posttranslational modification] 758793000862 intermolecular recognition site; other site 758793000863 dimerization interface [polypeptide binding]; other site 758793000864 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793000865 DNA binding residues [nucleotide binding] 758793000866 dimerization interface [polypeptide binding]; other site 758793000867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793000868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000869 active site 758793000870 phosphorylation site [posttranslational modification] 758793000871 intermolecular recognition site; other site 758793000872 dimerization interface [polypeptide binding]; other site 758793000873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793000874 DNA binding residues [nucleotide binding] 758793000875 dimerization interface [polypeptide binding]; other site 758793000876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793000877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000878 active site 758793000879 phosphorylation site [posttranslational modification] 758793000880 intermolecular recognition site; other site 758793000881 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793000882 DNA binding residues [nucleotide binding] 758793000883 dimerization interface [polypeptide binding]; other site 758793000884 PAS domain S-box; Region: sensory_box; TIGR00229 758793000885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793000886 putative active site [active] 758793000887 heme pocket [chemical binding]; other site 758793000888 PAS fold; Region: PAS_3; pfam08447 758793000889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793000890 dimer interface [polypeptide binding]; other site 758793000891 phosphorylation site [posttranslational modification] 758793000892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793000893 ATP binding site [chemical binding]; other site 758793000894 Mg2+ binding site [ion binding]; other site 758793000895 G-X-G motif; other site 758793000896 Response regulator receiver domain; Region: Response_reg; pfam00072 758793000897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793000898 active site 758793000899 phosphorylation site [posttranslational modification] 758793000900 intermolecular recognition site; other site 758793000901 dimerization interface [polypeptide binding]; other site 758793000902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793000903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793000904 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793000905 putative effector binding pocket; other site 758793000906 dimerization interface [polypeptide binding]; other site 758793000907 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793000908 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793000909 trimer interface [polypeptide binding]; other site 758793000910 eyelet of channel; other site 758793000911 CHRD domain; Region: CHRD; pfam07452 758793000912 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793000913 EcsC protein family; Region: EcsC; pfam12787 758793000914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793000915 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793000916 putative substrate translocation pore; other site 758793000917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793000918 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793000919 MarR family; Region: MarR; pfam01047 758793000920 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 758793000921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 758793000922 dimer interface [polypeptide binding]; other site 758793000923 active site 758793000924 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758793000925 substrate binding site [chemical binding]; other site 758793000926 catalytic residue [active] 758793000927 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758793000928 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758793000929 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758793000930 putative active site [active] 758793000931 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 758793000932 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 758793000933 active site 758793000934 putative substrate binding pocket [chemical binding]; other site 758793000935 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758793000936 homotrimer interaction site [polypeptide binding]; other site 758793000937 putative active site [active] 758793000938 conserved hypothetical protein; Region: TIGR02231 758793000939 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 758793000940 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 758793000941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 758793000942 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 758793000943 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 758793000944 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 758793000945 threonine dehydratase; Reviewed; Region: PRK09224 758793000946 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 758793000947 tetramer interface [polypeptide binding]; other site 758793000948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793000949 catalytic residue [active] 758793000950 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 758793000951 putative Ile/Val binding site [chemical binding]; other site 758793000952 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 758793000953 putative Ile/Val binding site [chemical binding]; other site 758793000954 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 758793000955 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793000956 FAD binding domain; Region: FAD_binding_4; pfam01565 758793000957 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793000958 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 758793000959 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 758793000960 Cysteine-rich domain; Region: CCG; pfam02754 758793000961 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 758793000962 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 758793000963 nucleotide binding site/active site [active] 758793000964 HIT family signature motif; other site 758793000965 catalytic residue [active] 758793000966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 758793000967 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 758793000968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793000969 S-adenosylmethionine binding site [chemical binding]; other site 758793000970 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 758793000971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 758793000972 SCP-2 sterol transfer family; Region: SCP2; pfam02036 758793000973 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 758793000974 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 758793000975 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 758793000976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793000977 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 758793000978 Uncharacterized conserved protein [Function unknown]; Region: COG2928 758793000979 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 758793000980 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 758793000981 dimer interface [polypeptide binding]; other site 758793000982 anticodon binding site; other site 758793000983 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 758793000984 homodimer interface [polypeptide binding]; other site 758793000985 motif 1; other site 758793000986 active site 758793000987 motif 2; other site 758793000988 GAD domain; Region: GAD; pfam02938 758793000989 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 758793000990 motif 3; other site 758793000991 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 758793000992 nudix motif; other site 758793000993 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 758793000994 PLD-like domain; Region: PLDc_2; pfam13091 758793000995 putative active site [active] 758793000996 catalytic site [active] 758793000997 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 758793000998 PLD-like domain; Region: PLDc_2; pfam13091 758793000999 putative active site [active] 758793001000 catalytic site [active] 758793001001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793001002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793001003 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 758793001004 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 758793001005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793001006 active site 758793001007 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 758793001008 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 758793001009 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793001010 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793001011 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 758793001012 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793001013 substrate binding site [chemical binding]; other site 758793001014 oxyanion hole (OAH) forming residues; other site 758793001015 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 758793001016 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793001017 dimer interface [polypeptide binding]; other site 758793001018 active site 758793001019 enoyl-CoA hydratase; Provisional; Region: PRK06688 758793001020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793001021 substrate binding site [chemical binding]; other site 758793001022 oxyanion hole (OAH) forming residues; other site 758793001023 trimer interface [polypeptide binding]; other site 758793001024 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 758793001025 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 758793001026 PAS domain S-box; Region: sensory_box; TIGR00229 758793001027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793001028 putative active site [active] 758793001029 heme pocket [chemical binding]; other site 758793001030 PAS fold; Region: PAS_4; pfam08448 758793001031 PAS domain; Region: PAS_9; pfam13426 758793001032 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793001033 putative active site [active] 758793001034 heme pocket [chemical binding]; other site 758793001035 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793001036 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793001037 metal binding site [ion binding]; metal-binding site 758793001038 active site 758793001039 I-site; other site 758793001040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793001041 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 758793001042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758793001043 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 758793001044 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 758793001045 Walker A/P-loop; other site 758793001046 ATP binding site [chemical binding]; other site 758793001047 Q-loop/lid; other site 758793001048 ABC transporter signature motif; other site 758793001049 Walker B; other site 758793001050 D-loop; other site 758793001051 H-loop/switch region; other site 758793001052 Protein of unknown function (DUF805); Region: DUF805; cl01224 758793001053 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 758793001054 cell density-dependent motility repressor; Provisional; Region: PRK10082 758793001055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793001056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793001057 dimerization interface [polypeptide binding]; other site 758793001058 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 758793001059 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 758793001060 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 758793001061 NAD(P) binding site [chemical binding]; other site 758793001062 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 758793001063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793001064 substrate binding pocket [chemical binding]; other site 758793001065 membrane-bound complex binding site; other site 758793001066 hinge residues; other site 758793001067 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793001068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793001069 dimer interface [polypeptide binding]; other site 758793001070 conserved gate region; other site 758793001071 putative PBP binding loops; other site 758793001072 ABC-ATPase subunit interface; other site 758793001073 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793001074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793001075 dimer interface [polypeptide binding]; other site 758793001076 conserved gate region; other site 758793001077 putative PBP binding loops; other site 758793001078 ABC-ATPase subunit interface; other site 758793001079 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758793001080 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793001081 Walker A/P-loop; other site 758793001082 ATP binding site [chemical binding]; other site 758793001083 Q-loop/lid; other site 758793001084 ABC transporter signature motif; other site 758793001085 Walker B; other site 758793001086 D-loop; other site 758793001087 H-loop/switch region; other site 758793001088 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 758793001089 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 758793001090 putative dimer interface [polypeptide binding]; other site 758793001091 putative active site [active] 758793001092 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 758793001093 active site 758793001094 substrate binding pocket [chemical binding]; other site 758793001095 dimer interface [polypeptide binding]; other site 758793001096 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 758793001097 OsmC-like protein; Region: OsmC; cl00767 758793001098 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 758793001099 23S rRNA interface [nucleotide binding]; other site 758793001100 L3 interface [polypeptide binding]; other site 758793001101 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 758793001102 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 758793001103 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 758793001104 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 758793001105 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 758793001106 active site 758793001107 HIGH motif; other site 758793001108 dimer interface [polypeptide binding]; other site 758793001109 KMSKS motif; other site 758793001110 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 758793001111 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793001112 RNA binding surface [nucleotide binding]; other site 758793001113 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 758793001114 putative active site [active] 758793001115 dimerization interface [polypeptide binding]; other site 758793001116 putative tRNAtyr binding site [nucleotide binding]; other site 758793001117 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 758793001118 Protein of unknown function (DUF877); Region: DUF877; pfam05943 758793001119 Protein of unknown function (DUF796); Region: DUF796; pfam05638 758793001120 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 758793001121 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 758793001122 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 758793001123 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 758793001124 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 758793001125 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 758793001126 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 758793001127 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 758793001128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793001129 Walker A motif; other site 758793001130 ATP binding site [chemical binding]; other site 758793001131 Walker B motif; other site 758793001132 arginine finger; other site 758793001133 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 758793001134 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 758793001135 RuvA N terminal domain; Region: RuvA_N; pfam01330 758793001136 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 758793001137 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 758793001138 active site 758793001139 putative DNA-binding cleft [nucleotide binding]; other site 758793001140 dimer interface [polypeptide binding]; other site 758793001141 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 758793001142 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 758793001143 purine monophosphate binding site [chemical binding]; other site 758793001144 dimer interface [polypeptide binding]; other site 758793001145 putative catalytic residues [active] 758793001146 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 758793001147 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 758793001148 DNA-binding protein Fis; Provisional; Region: PRK01905 758793001149 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 758793001150 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 758793001151 FMN binding site [chemical binding]; other site 758793001152 active site 758793001153 catalytic residues [active] 758793001154 substrate binding site [chemical binding]; other site 758793001155 hypothetical protein; Provisional; Region: PRK06996 758793001156 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793001157 proline aminopeptidase P II; Provisional; Region: PRK10879 758793001158 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 758793001159 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 758793001160 active site 758793001161 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 758793001162 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 758793001163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793001164 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 758793001165 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 758793001166 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 758793001167 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 758793001168 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 758793001169 ligand binding site [chemical binding]; other site 758793001170 homodimer interface [polypeptide binding]; other site 758793001171 NAD(P) binding site [chemical binding]; other site 758793001172 trimer interface B [polypeptide binding]; other site 758793001173 trimer interface A [polypeptide binding]; other site 758793001174 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 758793001175 nudix motif; other site 758793001176 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 758793001177 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 758793001178 Ligand Binding Site [chemical binding]; other site 758793001179 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793001180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793001181 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793001182 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793001183 putative glutathione S-transferase; Provisional; Region: PRK10357 758793001184 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 758793001185 putative C-terminal domain interface [polypeptide binding]; other site 758793001186 putative GSH binding site (G-site) [chemical binding]; other site 758793001187 putative dimer interface [polypeptide binding]; other site 758793001188 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 758793001189 dimer interface [polypeptide binding]; other site 758793001190 N-terminal domain interface [polypeptide binding]; other site 758793001191 putative substrate binding pocket (H-site) [chemical binding]; other site 758793001192 Protein of unknown function (DUF330); Region: DUF330; pfam03886 758793001193 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 758793001194 mce related protein; Region: MCE; pfam02470 758793001195 mce related protein; Region: MCE; pfam02470 758793001196 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 758793001197 Paraquat-inducible protein A; Region: PqiA; pfam04403 758793001198 zinc-finger; Region: zf-RING_3; pfam14369 758793001199 Paraquat-inducible protein A; Region: PqiA; pfam04403 758793001200 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 758793001201 YceI-like domain; Region: YceI; smart00867 758793001202 Uncharacterized conserved protein [Function unknown]; Region: COG2353 758793001203 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 758793001204 Protein export membrane protein; Region: SecD_SecF; pfam02355 758793001205 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 758793001206 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 758793001207 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 758793001208 Protein export membrane protein; Region: SecD_SecF; cl14618 758793001209 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 758793001210 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 758793001211 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 758793001212 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 758793001213 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 758793001214 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 758793001215 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 758793001216 generic binding surface II; other site 758793001217 ssDNA binding site; other site 758793001218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793001219 ATP binding site [chemical binding]; other site 758793001220 putative Mg++ binding site [ion binding]; other site 758793001221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793001222 nucleotide binding region [chemical binding]; other site 758793001223 ATP-binding site [chemical binding]; other site 758793001224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793001225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793001226 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 758793001227 dimerization interface [polypeptide binding]; other site 758793001228 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 758793001229 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 758793001230 tetramer interface [polypeptide binding]; other site 758793001231 heme binding pocket [chemical binding]; other site 758793001232 NADPH binding site [chemical binding]; other site 758793001233 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 758793001234 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 758793001235 dimerization interface [polypeptide binding]; other site 758793001236 DPS ferroxidase diiron center [ion binding]; other site 758793001237 ion pore; other site 758793001238 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 758793001239 UbiA prenyltransferase family; Region: UbiA; pfam01040 758793001240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793001241 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 758793001242 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 758793001243 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 758793001244 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758793001245 catalytic residue [active] 758793001246 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 758793001247 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758793001248 Cysteine-rich domain; Region: CCG; pfam02754 758793001249 Cysteine-rich domain; Region: CCG; pfam02754 758793001250 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 758793001251 FAD binding domain; Region: FAD_binding_4; pfam01565 758793001252 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 758793001253 FAD binding domain; Region: FAD_binding_4; pfam01565 758793001254 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793001255 FAD binding domain; Region: FAD_binding_4; pfam01565 758793001256 Chlorite dismutase; Region: Chlor_dismutase; cl01280 758793001257 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 758793001258 Restriction endonuclease; Region: Mrr_cat; pfam04471 758793001259 AIPR protein; Region: AIPR; pfam10592 758793001260 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 758793001261 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 758793001262 protease TldD; Provisional; Region: tldD; PRK10735 758793001263 nitrilase; Region: PLN02798 758793001264 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 758793001265 putative active site [active] 758793001266 catalytic triad [active] 758793001267 dimer interface [polypeptide binding]; other site 758793001268 TIGR02099 family protein; Region: TIGR02099 758793001269 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 758793001270 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 758793001271 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 758793001272 metal binding triad; other site 758793001273 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 758793001274 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 758793001275 metal binding triad; other site 758793001276 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 758793001277 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 758793001278 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 758793001279 Walker A/P-loop; other site 758793001280 ATP binding site [chemical binding]; other site 758793001281 Q-loop/lid; other site 758793001282 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 758793001283 ABC transporter signature motif; other site 758793001284 Walker B; other site 758793001285 D-loop; other site 758793001286 H-loop/switch region; other site 758793001287 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 758793001288 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 758793001289 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 758793001290 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 758793001291 ferrochelatase; Reviewed; Region: hemH; PRK00035 758793001292 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 758793001293 C-terminal domain interface [polypeptide binding]; other site 758793001294 active site 758793001295 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 758793001296 active site 758793001297 N-terminal domain interface [polypeptide binding]; other site 758793001298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793001299 RNA binding surface [nucleotide binding]; other site 758793001300 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 758793001301 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 758793001302 dimer interface [polypeptide binding]; other site 758793001303 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 758793001304 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 758793001305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 758793001306 nucleotide binding site [chemical binding]; other site 758793001307 chaperone protein DnaJ; Provisional; Region: PRK10767 758793001308 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 758793001309 HSP70 interaction site [polypeptide binding]; other site 758793001310 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 758793001311 Zn binding sites [ion binding]; other site 758793001312 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 758793001313 dimer interface [polypeptide binding]; other site 758793001314 chorismate binding enzyme; Region: Chorismate_bind; cl10555 758793001315 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 758793001316 hypothetical protein; Provisional; Region: PRK07546 758793001317 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 758793001318 substrate-cofactor binding pocket; other site 758793001319 homodimer interface [polypeptide binding]; other site 758793001320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793001321 catalytic residue [active] 758793001322 galactonate dehydratase; Provisional; Region: PRK14017 758793001323 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 758793001324 putative active site pocket [active] 758793001325 putative metal binding site [ion binding]; other site 758793001326 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793001327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793001328 DNA-binding site [nucleotide binding]; DNA binding site 758793001329 FCD domain; Region: FCD; pfam07729 758793001330 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 758793001331 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 758793001332 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758793001333 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 758793001334 active site residue [active] 758793001335 EamA-like transporter family; Region: EamA; pfam00892 758793001336 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758793001337 EamA-like transporter family; Region: EamA; pfam00892 758793001338 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 758793001339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793001340 dimer interface [polypeptide binding]; other site 758793001341 active site 758793001342 glutathione binding site [chemical binding]; other site 758793001343 Protein of unknown function DUF45; Region: DUF45; pfam01863 758793001344 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758793001345 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758793001346 putative acyl-acceptor binding pocket; other site 758793001347 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 758793001348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793001349 active site 758793001350 motif I; other site 758793001351 motif II; other site 758793001352 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 758793001353 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 758793001354 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 758793001355 dimer interface [polypeptide binding]; other site 758793001356 motif 1; other site 758793001357 active site 758793001358 motif 2; other site 758793001359 motif 3; other site 758793001360 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 758793001361 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 758793001362 putative active site [active] 758793001363 catalytic triad [active] 758793001364 putative dimer interface [polypeptide binding]; other site 758793001365 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 758793001366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 758793001367 Transporter associated domain; Region: CorC_HlyC; smart01091 758793001368 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 758793001369 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 758793001370 putative active site pocket [active] 758793001371 dimerization interface [polypeptide binding]; other site 758793001372 putative catalytic residue [active] 758793001373 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 758793001374 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 758793001375 PhoH-like protein; Region: PhoH; pfam02562 758793001376 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 758793001377 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 758793001378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793001379 FeS/SAM binding site; other site 758793001380 TRAM domain; Region: TRAM; pfam01938 758793001381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793001382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793001383 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793001384 putative effector binding pocket; other site 758793001385 dimerization interface [polypeptide binding]; other site 758793001386 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 758793001387 active site 758793001388 MFS transport protein AraJ; Provisional; Region: PRK10091 758793001389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793001390 putative substrate translocation pore; other site 758793001391 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 758793001392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793001393 motif II; other site 758793001394 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 758793001395 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 758793001396 glycerol kinase; Provisional; Region: glpK; PRK00047 758793001397 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 758793001398 N- and C-terminal domain interface [polypeptide binding]; other site 758793001399 active site 758793001400 MgATP binding site [chemical binding]; other site 758793001401 catalytic site [active] 758793001402 metal binding site [ion binding]; metal-binding site 758793001403 glycerol binding site [chemical binding]; other site 758793001404 homotetramer interface [polypeptide binding]; other site 758793001405 homodimer interface [polypeptide binding]; other site 758793001406 FBP binding site [chemical binding]; other site 758793001407 protein IIAGlc interface [polypeptide binding]; other site 758793001408 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 758793001409 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 758793001410 citrate-proton symporter; Provisional; Region: PRK15075 758793001411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793001412 putative substrate translocation pore; other site 758793001413 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 758793001414 dinuclear metal binding motif [ion binding]; other site 758793001415 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 758793001416 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758793001417 DEAD-like helicases superfamily; Region: DEXDc; smart00487 758793001418 ATP binding site [chemical binding]; other site 758793001419 Mg++ binding site [ion binding]; other site 758793001420 motif III; other site 758793001421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793001422 nucleotide binding region [chemical binding]; other site 758793001423 ATP-binding site [chemical binding]; other site 758793001424 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 758793001425 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 758793001426 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793001427 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793001428 Cytochrome c; Region: Cytochrom_C; pfam00034 758793001429 Cytochrome c; Region: Cytochrom_C; cl11414 758793001430 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793001431 Cytochrome c; Region: Cytochrom_C; cl11414 758793001432 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 758793001433 oligomerization interface [polypeptide binding]; other site 758793001434 active site 758793001435 metal binding site [ion binding]; metal-binding site 758793001436 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 758793001437 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 758793001438 Substrate-binding site [chemical binding]; other site 758793001439 Substrate specificity [chemical binding]; other site 758793001440 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 758793001441 catalytic center binding site [active] 758793001442 ATP binding site [chemical binding]; other site 758793001443 poly(A) polymerase; Region: pcnB; TIGR01942 758793001444 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 758793001445 active site 758793001446 NTP binding site [chemical binding]; other site 758793001447 metal binding triad [ion binding]; metal-binding site 758793001448 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 758793001449 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 758793001450 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 758793001451 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 758793001452 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 758793001453 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 758793001454 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 758793001455 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 758793001456 dimerization interface [polypeptide binding]; other site 758793001457 putative ATP binding site [chemical binding]; other site 758793001458 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 758793001459 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 758793001460 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 758793001461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793001462 ATP binding site [chemical binding]; other site 758793001463 Mg2+ binding site [ion binding]; other site 758793001464 G-X-G motif; other site 758793001465 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 758793001466 ATP binding site [chemical binding]; other site 758793001467 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 758793001468 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 758793001469 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 758793001470 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758793001471 Peptidase family M23; Region: Peptidase_M23; pfam01551 758793001472 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 758793001473 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 758793001474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793001475 substrate binding pocket [chemical binding]; other site 758793001476 membrane-bound complex binding site; other site 758793001477 hinge residues; other site 758793001478 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 758793001479 hypothetical protein; Provisional; Region: PRK07483 758793001480 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793001481 inhibitor-cofactor binding pocket; inhibition site 758793001482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793001483 catalytic residue [active] 758793001484 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758793001485 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758793001486 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758793001487 putative active site [active] 758793001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793001489 putative substrate translocation pore; other site 758793001490 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 758793001491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793001492 HAMP domain; Region: HAMP; pfam00672 758793001493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793001494 dimer interface [polypeptide binding]; other site 758793001495 phosphorylation site [posttranslational modification] 758793001496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793001497 ATP binding site [chemical binding]; other site 758793001498 Mg2+ binding site [ion binding]; other site 758793001499 G-X-G motif; other site 758793001500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793001501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793001502 active site 758793001503 phosphorylation site [posttranslational modification] 758793001504 intermolecular recognition site; other site 758793001505 dimerization interface [polypeptide binding]; other site 758793001506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793001507 DNA binding site [nucleotide binding] 758793001508 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 758793001509 hexamer interface [polypeptide binding]; other site 758793001510 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 758793001511 Walker A motif; other site 758793001512 ATP binding site [chemical binding]; other site 758793001513 Walker B motif; other site 758793001514 RecX family; Region: RecX; cl00936 758793001515 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 758793001516 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 758793001517 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 758793001518 CoA-ligase; Region: Ligase_CoA; pfam00549 758793001519 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 758793001520 CoA binding domain; Region: CoA_binding; smart00881 758793001521 CoA-ligase; Region: Ligase_CoA; pfam00549 758793001522 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 758793001523 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 758793001524 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 758793001525 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 758793001526 O-Antigen ligase; Region: Wzy_C; pfam04932 758793001527 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 758793001528 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 758793001529 trimer interface [polypeptide binding]; other site 758793001530 dimer interface [polypeptide binding]; other site 758793001531 putative active site [active] 758793001532 Peptidase family M48; Region: Peptidase_M48; cl12018 758793001533 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 758793001534 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 758793001535 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 758793001536 SnoaL-like domain; Region: SnoaL_3; pfam13474 758793001537 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 758793001538 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 758793001539 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 758793001540 putative active site [active] 758793001541 Zinc-finger domain; Region: zf-CHCC; cl01821 758793001542 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 758793001543 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 758793001544 homodimer interface [polypeptide binding]; other site 758793001545 substrate-cofactor binding pocket; other site 758793001546 catalytic residue [active] 758793001547 AzlC protein; Region: AzlC; cl00570 758793001548 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 758793001549 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 758793001550 Phosphoglycerate kinase; Region: PGK; pfam00162 758793001551 substrate binding site [chemical binding]; other site 758793001552 hinge regions; other site 758793001553 ADP binding site [chemical binding]; other site 758793001554 catalytic site [active] 758793001555 pyruvate kinase; Provisional; Region: PRK05826 758793001556 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 758793001557 domain interfaces; other site 758793001558 active site 758793001559 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 758793001560 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 758793001561 intersubunit interface [polypeptide binding]; other site 758793001562 active site 758793001563 zinc binding site [ion binding]; other site 758793001564 Na+ binding site [ion binding]; other site 758793001565 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 758793001566 ATP binding site [chemical binding]; other site 758793001567 active site 758793001568 substrate binding site [chemical binding]; other site 758793001569 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 758793001570 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 758793001571 ATP-grasp domain; Region: ATP-grasp; pfam02222 758793001572 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 758793001573 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 758793001574 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 758793001575 active site 758793001576 catalytic triad [active] 758793001577 oxyanion hole [active] 758793001578 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 758793001579 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 758793001580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793001581 active site 758793001582 phosphorylation site [posttranslational modification] 758793001583 intermolecular recognition site; other site 758793001584 dimerization interface [polypeptide binding]; other site 758793001585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793001586 DNA binding site [nucleotide binding] 758793001587 sensor protein QseC; Provisional; Region: PRK10337 758793001588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793001589 dimer interface [polypeptide binding]; other site 758793001590 phosphorylation site [posttranslational modification] 758793001591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793001592 ATP binding site [chemical binding]; other site 758793001593 Mg2+ binding site [ion binding]; other site 758793001594 G-X-G motif; other site 758793001595 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793001596 ligand binding site [chemical binding]; other site 758793001597 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 758793001598 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 758793001599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 758793001600 protein binding site [polypeptide binding]; other site 758793001601 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 758793001602 protein binding site [polypeptide binding]; other site 758793001603 Domain of unknown function (DUF427); Region: DUF427; pfam04248 758793001604 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 758793001605 hydrophobic ligand binding site; other site 758793001606 Isochorismatase family; Region: Isochorismatase; pfam00857 758793001607 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 758793001608 catalytic triad [active] 758793001609 conserved cis-peptide bond; other site 758793001610 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 758793001611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793001612 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 758793001613 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 758793001614 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793001615 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793001616 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 758793001617 Protein export membrane protein; Region: SecD_SecF; cl14618 758793001618 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793001619 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 758793001620 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793001621 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793001622 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 758793001623 Protein export membrane protein; Region: SecD_SecF; cl14618 758793001624 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 758793001625 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793001626 xanthine permease; Region: pbuX; TIGR03173 758793001627 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 758793001628 D-xylulose kinase; Region: XylB; TIGR01312 758793001629 nucleotide binding site [chemical binding]; other site 758793001630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793001631 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793001632 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793001633 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 758793001634 dimerization interface [polypeptide binding]; other site 758793001635 putative active cleft [active] 758793001636 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 758793001637 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 758793001638 substrate binding site [chemical binding]; other site 758793001639 catalytic Zn binding site [ion binding]; other site 758793001640 NAD binding site [chemical binding]; other site 758793001641 structural Zn binding site [ion binding]; other site 758793001642 dimer interface [polypeptide binding]; other site 758793001643 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 758793001644 S-formylglutathione hydrolase; Region: PLN02442 758793001645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793001646 TPR motif; other site 758793001647 TPR repeat; Region: TPR_11; pfam13414 758793001648 binding surface 758793001649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793001650 binding surface 758793001651 TPR motif; other site 758793001652 TPR repeat; Region: TPR_11; pfam13414 758793001653 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793001654 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 758793001655 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758793001656 ABC-ATPase subunit interface; other site 758793001657 dimer interface [polypeptide binding]; other site 758793001658 putative PBP binding regions; other site 758793001659 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 758793001660 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 758793001661 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 758793001662 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 758793001663 metal binding site [ion binding]; metal-binding site 758793001664 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 758793001665 metal binding site 2 [ion binding]; metal-binding site 758793001666 putative DNA binding helix; other site 758793001667 metal binding site 1 [ion binding]; metal-binding site 758793001668 dimer interface [polypeptide binding]; other site 758793001669 structural Zn2+ binding site [ion binding]; other site 758793001670 sorbitol dehydrogenase; Provisional; Region: PRK07067 758793001671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793001672 NAD(P) binding site [chemical binding]; other site 758793001673 active site 758793001674 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 758793001675 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758793001676 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 758793001677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793001678 dimer interface [polypeptide binding]; other site 758793001679 conserved gate region; other site 758793001680 putative PBP binding loops; other site 758793001681 ABC-ATPase subunit interface; other site 758793001682 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758793001683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793001684 dimer interface [polypeptide binding]; other site 758793001685 conserved gate region; other site 758793001686 putative PBP binding loops; other site 758793001687 ABC-ATPase subunit interface; other site 758793001688 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 758793001689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793001690 motif II; other site 758793001691 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 758793001692 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 758793001693 Walker A/P-loop; other site 758793001694 ATP binding site [chemical binding]; other site 758793001695 Q-loop/lid; other site 758793001696 ABC transporter signature motif; other site 758793001697 Walker B; other site 758793001698 D-loop; other site 758793001699 H-loop/switch region; other site 758793001700 TOBE domain; Region: TOBE_2; pfam08402 758793001701 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 758793001702 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 758793001703 MOSC domain; Region: MOSC; pfam03473 758793001704 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 758793001705 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 758793001706 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 758793001707 N- and C-terminal domain interface [polypeptide binding]; other site 758793001708 D-xylulose kinase; Region: XylB; TIGR01312 758793001709 active site 758793001710 MgATP binding site [chemical binding]; other site 758793001711 catalytic site [active] 758793001712 metal binding site [ion binding]; metal-binding site 758793001713 xylulose binding site [chemical binding]; other site 758793001714 homodimer interface [polypeptide binding]; other site 758793001715 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 758793001716 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 758793001717 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 758793001718 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 758793001719 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 758793001720 fumarylacetoacetase; Region: PLN02856 758793001721 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 758793001722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793001723 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793001724 acyl-activating enzyme (AAE) consensus motif; other site 758793001725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793001726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793001727 putative substrate translocation pore; other site 758793001728 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 758793001729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793001730 putative substrate translocation pore; other site 758793001731 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 758793001732 putative active site [active] 758793001733 putative metal binding site [ion binding]; other site 758793001734 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 758793001735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 758793001736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793001737 putative Mg++ binding site [ion binding]; other site 758793001738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793001739 nucleotide binding region [chemical binding]; other site 758793001740 ATP-binding site [chemical binding]; other site 758793001741 DEAD/H associated; Region: DEAD_assoc; pfam08494 758793001742 ATP-dependent DNA ligase; Validated; Region: PRK09247 758793001743 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 758793001744 active site 758793001745 DNA binding site [nucleotide binding] 758793001746 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 758793001747 DNA binding site [nucleotide binding] 758793001748 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 758793001749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793001750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793001751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793001752 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793001753 dimerization interface [polypeptide binding]; other site 758793001754 putative effector binding pocket; other site 758793001755 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 758793001756 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 758793001757 TrkA-C domain; Region: TrkA_C; pfam02080 758793001758 TrkA-C domain; Region: TrkA_C; pfam02080 758793001759 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 758793001760 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 758793001761 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 758793001762 TrkA-C domain; Region: TrkA_C; pfam02080 758793001763 TrkA-C domain; Region: TrkA_C; pfam02080 758793001764 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 758793001765 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793001766 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793001767 active site 758793001768 catalytic tetrad [active] 758793001769 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 758793001770 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793001771 Walker A/P-loop; other site 758793001772 ATP binding site [chemical binding]; other site 758793001773 Q-loop/lid; other site 758793001774 ABC transporter signature motif; other site 758793001775 Walker B; other site 758793001776 D-loop; other site 758793001777 H-loop/switch region; other site 758793001778 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793001779 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 758793001780 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793001781 Walker A/P-loop; other site 758793001782 ATP binding site [chemical binding]; other site 758793001783 Q-loop/lid; other site 758793001784 ABC transporter signature motif; other site 758793001785 Walker B; other site 758793001786 D-loop; other site 758793001787 H-loop/switch region; other site 758793001788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793001789 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 758793001790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793001791 putative PBP binding loops; other site 758793001792 dimer interface [polypeptide binding]; other site 758793001793 ABC-ATPase subunit interface; other site 758793001794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758793001795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793001796 dimer interface [polypeptide binding]; other site 758793001797 conserved gate region; other site 758793001798 putative PBP binding loops; other site 758793001799 ABC-ATPase subunit interface; other site 758793001800 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793001801 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 758793001802 Cupin domain; Region: Cupin_2; cl17218 758793001803 elongation factor G; Reviewed; Region: PRK00007 758793001804 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 758793001805 G1 box; other site 758793001806 putative GEF interaction site [polypeptide binding]; other site 758793001807 GTP/Mg2+ binding site [chemical binding]; other site 758793001808 Switch I region; other site 758793001809 G2 box; other site 758793001810 G3 box; other site 758793001811 Switch II region; other site 758793001812 G4 box; other site 758793001813 G5 box; other site 758793001814 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 758793001815 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 758793001816 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 758793001817 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 758793001818 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 758793001819 pseudouridine synthase; Region: TIGR00093 758793001820 active site 758793001821 isocitrate dehydrogenase; Validated; Region: PRK07362 758793001822 isocitrate dehydrogenase; Reviewed; Region: PRK07006 758793001823 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 758793001824 DNA-binding site [nucleotide binding]; DNA binding site 758793001825 RNA-binding motif; other site 758793001826 Uncharacterized conserved protein [Function unknown]; Region: COG2127 758793001827 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 758793001828 Clp amino terminal domain; Region: Clp_N; pfam02861 758793001829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793001830 Walker A motif; other site 758793001831 ATP binding site [chemical binding]; other site 758793001832 Walker B motif; other site 758793001833 arginine finger; other site 758793001834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793001835 Walker A motif; other site 758793001836 ATP binding site [chemical binding]; other site 758793001837 Walker B motif; other site 758793001838 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 758793001839 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 758793001840 trimer interface [polypeptide binding]; other site 758793001841 active site 758793001842 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 758793001843 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 758793001844 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 758793001845 Flavoprotein; Region: Flavoprotein; pfam02441 758793001846 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 758793001847 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 758793001848 lipoprotein signal peptidase; Provisional; Region: PRK14787 758793001849 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 758793001850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 758793001851 active site 758793001852 HIGH motif; other site 758793001853 nucleotide binding site [chemical binding]; other site 758793001854 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 758793001855 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 758793001856 active site 758793001857 KMSKS motif; other site 758793001858 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 758793001859 tRNA binding surface [nucleotide binding]; other site 758793001860 anticodon binding site; other site 758793001861 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 758793001862 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 758793001863 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 758793001864 active site 758793001865 Riboflavin kinase; Region: Flavokinase; smart00904 758793001866 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 758793001867 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 758793001868 active site 758793001869 substrate binding site [chemical binding]; other site 758793001870 cosubstrate binding site; other site 758793001871 catalytic site [active] 758793001872 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 758793001873 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 758793001874 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793001875 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793001876 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 758793001877 Fatty acid desaturase; Region: FA_desaturase; pfam00487 758793001878 Di-iron ligands [ion binding]; other site 758793001879 Transposase; Region: DDE_Tnp_ISL3; pfam01610 758793001880 quinolinate synthetase; Provisional; Region: PRK09375 758793001881 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 758793001882 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 758793001883 dimerization interface [polypeptide binding]; other site 758793001884 active site 758793001885 L-aspartate oxidase; Provisional; Region: PRK09077 758793001886 L-aspartate oxidase; Provisional; Region: PRK06175 758793001887 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 758793001888 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 758793001889 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 758793001890 hypothetical protein; Reviewed; Region: PRK00024 758793001891 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 758793001892 MPN+ (JAMM) motif; other site 758793001893 Zinc-binding site [ion binding]; other site 758793001894 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 758793001895 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 758793001896 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 758793001897 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 758793001898 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793001899 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 758793001900 dimerization interface [polypeptide binding]; other site 758793001901 ligand binding site [chemical binding]; other site 758793001902 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793001903 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793001904 TM-ABC transporter signature motif; other site 758793001905 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793001906 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793001907 TM-ABC transporter signature motif; other site 758793001908 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793001909 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793001910 Walker A/P-loop; other site 758793001911 ATP binding site [chemical binding]; other site 758793001912 Q-loop/lid; other site 758793001913 ABC transporter signature motif; other site 758793001914 Walker B; other site 758793001915 D-loop; other site 758793001916 H-loop/switch region; other site 758793001917 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793001918 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793001919 Walker A/P-loop; other site 758793001920 ATP binding site [chemical binding]; other site 758793001921 Q-loop/lid; other site 758793001922 ABC transporter signature motif; other site 758793001923 Walker B; other site 758793001924 D-loop; other site 758793001925 H-loop/switch region; other site 758793001926 putative acetyltransferase; Provisional; Region: PRK03624 758793001927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793001928 Coenzyme A binding pocket [chemical binding]; other site 758793001929 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 758793001930 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793001931 inhibitor-cofactor binding pocket; inhibition site 758793001932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793001933 catalytic residue [active] 758793001934 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 758793001935 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793001936 catalytic loop [active] 758793001937 iron binding site [ion binding]; other site 758793001938 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 758793001939 FAD binding pocket [chemical binding]; other site 758793001940 FAD binding motif [chemical binding]; other site 758793001941 phosphate binding motif [ion binding]; other site 758793001942 beta-alpha-beta structure motif; other site 758793001943 NAD binding pocket [chemical binding]; other site 758793001944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793001945 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793001946 active site 758793001947 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 758793001948 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793001949 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793001950 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 758793001951 pseudouridine synthase; Region: TIGR00093 758793001952 active site 758793001953 uracil binding [chemical binding]; other site 758793001954 TIGR03118 family protein; Region: PEPCTERM_chp_1 758793001955 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 758793001956 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 758793001957 Helix-turn-helix domain; Region: HTH_39; pfam14090 758793001958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 758793001959 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 758793001960 active site 758793001961 metal binding site [ion binding]; metal-binding site 758793001962 interdomain interaction site; other site 758793001963 integrase; Provisional; Region: PRK09692 758793001964 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 758793001965 active site 758793001966 Int/Topo IB signature motif; other site 758793001967 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793001968 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 758793001969 putative ligand binding site [chemical binding]; other site 758793001970 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 758793001971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793001972 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 758793001973 substrate binding site [chemical binding]; other site 758793001974 dimerization interface [polypeptide binding]; other site 758793001975 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 758793001976 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758793001977 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758793001978 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 758793001979 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 758793001980 Active Sites [active] 758793001981 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 758793001982 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 758793001983 Active Sites [active] 758793001984 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 758793001985 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 758793001986 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 758793001987 CysD dimerization site [polypeptide binding]; other site 758793001988 G1 box; other site 758793001989 putative GEF interaction site [polypeptide binding]; other site 758793001990 GTP/Mg2+ binding site [chemical binding]; other site 758793001991 Switch I region; other site 758793001992 G2 box; other site 758793001993 G3 box; other site 758793001994 Switch II region; other site 758793001995 G4 box; other site 758793001996 G5 box; other site 758793001997 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 758793001998 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 758793001999 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 758793002000 active site 758793002001 SAM binding site [chemical binding]; other site 758793002002 homodimer interface [polypeptide binding]; other site 758793002003 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 758793002004 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 758793002005 putative active site [active] 758793002006 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 758793002007 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 758793002008 Predicted permeases [General function prediction only]; Region: COG0795 758793002009 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 758793002010 multifunctional aminopeptidase A; Provisional; Region: PRK00913 758793002011 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 758793002012 interface (dimer of trimers) [polypeptide binding]; other site 758793002013 Substrate-binding/catalytic site; other site 758793002014 Zn-binding sites [ion binding]; other site 758793002015 DNA polymerase III subunit chi; Validated; Region: PRK05728 758793002016 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 758793002017 Cytochrome c; Region: Cytochrom_C; cl11414 758793002018 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 758793002019 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 758793002020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793002021 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 758793002022 putative dimerization interface [polypeptide binding]; other site 758793002023 putative substrate binding pocket [chemical binding]; other site 758793002024 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 758793002025 Protein of unknown function (DUF541); Region: SIMPL; cl01077 758793002026 Uncharacterized conserved protein [Function unknown]; Region: COG2947 758793002027 Cell division protein ZapA; Region: ZapA; pfam05164 758793002028 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 758793002029 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793002030 N-terminal plug; other site 758793002031 ligand-binding site [chemical binding]; other site 758793002032 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 758793002033 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758793002034 dimer interface [polypeptide binding]; other site 758793002035 ABC-ATPase subunit interface; other site 758793002036 putative PBP binding regions; other site 758793002037 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758793002038 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758793002039 Walker A/P-loop; other site 758793002040 ATP binding site [chemical binding]; other site 758793002041 Q-loop/lid; other site 758793002042 ABC transporter signature motif; other site 758793002043 Walker B; other site 758793002044 D-loop; other site 758793002045 H-loop/switch region; other site 758793002046 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 758793002047 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 758793002048 putative dimer interface [polypeptide binding]; other site 758793002049 active site pocket [active] 758793002050 putative cataytic base [active] 758793002051 cobalamin synthase; Reviewed; Region: cobS; PRK00235 758793002052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 758793002053 catalytic core [active] 758793002054 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 758793002055 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 758793002056 cobalamin binding residues [chemical binding]; other site 758793002057 putative BtuC binding residues; other site 758793002058 dimer interface [polypeptide binding]; other site 758793002059 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 758793002060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793002061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793002062 homodimer interface [polypeptide binding]; other site 758793002063 catalytic residue [active] 758793002064 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 758793002065 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 758793002066 homotrimer interface [polypeptide binding]; other site 758793002067 Walker A motif; other site 758793002068 GTP binding site [chemical binding]; other site 758793002069 Walker B motif; other site 758793002070 cobyric acid synthase; Provisional; Region: PRK00784 758793002071 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 758793002072 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 758793002073 catalytic triad [active] 758793002074 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 758793002075 CoenzymeA binding site [chemical binding]; other site 758793002076 subunit interaction site [polypeptide binding]; other site 758793002077 PHB binding site; other site 758793002078 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 758793002079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793002080 P-loop; other site 758793002081 Magnesium ion binding site [ion binding]; other site 758793002082 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 758793002083 tetramerization interface [polypeptide binding]; other site 758793002084 active site 758793002085 pantoate--beta-alanine ligase; Region: panC; TIGR00018 758793002086 Pantoate-beta-alanine ligase; Region: PanC; cd00560 758793002087 active site 758793002088 ATP-binding site [chemical binding]; other site 758793002089 pantoate-binding site; other site 758793002090 HXXH motif; other site 758793002091 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 758793002092 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 758793002093 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 758793002094 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 758793002095 Surface antigen; Region: Bac_surface_Ag; pfam01103 758793002096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 758793002097 Family of unknown function (DUF490); Region: DUF490; pfam04357 758793002098 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 758793002099 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 758793002100 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 758793002101 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 758793002102 PapC N-terminal domain; Region: PapC_N; pfam13954 758793002103 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 758793002104 PapC C-terminal domain; Region: PapC_C; pfam13953 758793002105 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 758793002106 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 758793002107 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 758793002108 active site 758793002109 HIGH motif; other site 758793002110 KMSKS motif; other site 758793002111 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 758793002112 tRNA binding surface [nucleotide binding]; other site 758793002113 anticodon binding site; other site 758793002114 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 758793002115 dimer interface [polypeptide binding]; other site 758793002116 putative tRNA-binding site [nucleotide binding]; other site 758793002117 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 758793002118 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793002119 ligand binding site [chemical binding]; other site 758793002120 Domain of unknown function DUF59; Region: DUF59; pfam01883 758793002121 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 758793002122 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 758793002123 Walker A motif; other site 758793002124 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 758793002125 E-class dimer interface [polypeptide binding]; other site 758793002126 P-class dimer interface [polypeptide binding]; other site 758793002127 active site 758793002128 Cu2+ binding site [ion binding]; other site 758793002129 Zn2+ binding site [ion binding]; other site 758793002130 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 758793002131 trimer interface [polypeptide binding]; other site 758793002132 active site 758793002133 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 758793002134 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 758793002135 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758793002136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793002137 catalytic residue [active] 758793002138 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 758793002139 glutathionine S-transferase; Provisional; Region: PRK10542 758793002140 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 758793002141 C-terminal domain interface [polypeptide binding]; other site 758793002142 GSH binding site (G-site) [chemical binding]; other site 758793002143 dimer interface [polypeptide binding]; other site 758793002144 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 758793002145 dimer interface [polypeptide binding]; other site 758793002146 N-terminal domain interface [polypeptide binding]; other site 758793002147 substrate binding pocket (H-site) [chemical binding]; other site 758793002148 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 758793002149 argininosuccinate lyase; Provisional; Region: PRK00855 758793002150 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 758793002151 active sites [active] 758793002152 tetramer interface [polypeptide binding]; other site 758793002153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758793002154 non-specific DNA binding site [nucleotide binding]; other site 758793002155 salt bridge; other site 758793002156 sequence-specific DNA binding site [nucleotide binding]; other site 758793002157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758793002158 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793002159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793002160 S-adenosylmethionine binding site [chemical binding]; other site 758793002161 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 758793002162 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 758793002163 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 758793002164 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 758793002165 active site 758793002166 domain interfaces; other site 758793002167 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 758793002168 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 758793002169 active site 758793002170 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 758793002171 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 758793002172 HemY protein N-terminus; Region: HemY_N; pfam07219 758793002173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002174 TPR motif; other site 758793002175 binding surface 758793002176 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 758793002177 active site 758793002178 catalytic triad [active] 758793002179 oxyanion hole [active] 758793002180 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 758793002181 active site residue [active] 758793002182 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 758793002183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793002184 S-adenosylmethionine binding site [chemical binding]; other site 758793002185 Predicted membrane protein [Function unknown]; Region: COG2860 758793002186 UPF0126 domain; Region: UPF0126; pfam03458 758793002187 UPF0126 domain; Region: UPF0126; pfam03458 758793002188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 758793002189 Smr domain; Region: Smr; pfam01713 758793002190 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 758793002191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793002192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793002193 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 758793002194 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 758793002195 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 758793002196 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 758793002197 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 758793002198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793002199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793002200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793002201 dimerization interface [polypeptide binding]; other site 758793002202 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 758793002203 agmatinase; Region: agmatinase; TIGR01230 758793002204 oligomer interface [polypeptide binding]; other site 758793002205 putative active site [active] 758793002206 Mn binding site [ion binding]; other site 758793002207 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 758793002208 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 758793002209 recombination factor protein RarA; Reviewed; Region: PRK13342 758793002210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793002211 Walker A motif; other site 758793002212 ATP binding site [chemical binding]; other site 758793002213 Walker B motif; other site 758793002214 arginine finger; other site 758793002215 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 758793002216 seryl-tRNA synthetase; Provisional; Region: PRK05431 758793002217 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 758793002218 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 758793002219 dimer interface [polypeptide binding]; other site 758793002220 active site 758793002221 motif 1; other site 758793002222 motif 2; other site 758793002223 motif 3; other site 758793002224 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 758793002225 active site 758793002226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793002227 Coenzyme A binding pocket [chemical binding]; other site 758793002228 septum formation inhibitor; Reviewed; Region: PRK01973 758793002229 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 758793002230 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 758793002231 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 758793002232 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 758793002233 Switch I; other site 758793002234 Switch II; other site 758793002235 cell division topological specificity factor MinE; Provisional; Region: PRK13989 758793002236 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 758793002237 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 758793002238 putative ion selectivity filter; other site 758793002239 putative pore gating glutamate residue; other site 758793002240 putative H+/Cl- coupling transport residue; other site 758793002241 OpgC protein; Region: OpgC_C; pfam10129 758793002242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793002243 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793002244 putative substrate translocation pore; other site 758793002245 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 758793002246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793002247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793002248 putative substrate translocation pore; other site 758793002249 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 758793002250 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 758793002251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793002252 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758793002253 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 758793002254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793002255 catalytic residue [active] 758793002256 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 758793002257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 758793002258 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 758793002259 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 758793002260 D-pathway; other site 758793002261 Subunit I/VIIc interface [polypeptide binding]; other site 758793002262 Subunit I/IV interface [polypeptide binding]; other site 758793002263 Subunit I/II interface [polypeptide binding]; other site 758793002264 Low-spin heme (heme a) binding site [chemical binding]; other site 758793002265 Subunit I/III interface [polypeptide binding]; other site 758793002266 Subunit I/VIIa interface [polypeptide binding]; other site 758793002267 Subunit I/VIa interface [polypeptide binding]; other site 758793002268 Dimer interface; other site 758793002269 Putative water exit pathway; other site 758793002270 Binuclear center (heme a3/CuB) [ion binding]; other site 758793002271 K-pathway; other site 758793002272 Subunit I/Vb interface [polypeptide binding]; other site 758793002273 Putative proton exit pathway; other site 758793002274 Subunit I/VIb interface; other site 758793002275 Subunit I/VIc interface [polypeptide binding]; other site 758793002276 Electron transfer pathway; other site 758793002277 Subunit I/VIIIb interface [polypeptide binding]; other site 758793002278 Subunit I/VIIb interface [polypeptide binding]; other site 758793002279 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 758793002280 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 758793002281 putative Cl- selectivity filter; other site 758793002282 putative pore gating glutamate residue; other site 758793002283 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 758793002284 Moco binding site; other site 758793002285 metal coordination site [ion binding]; other site 758793002286 dimerization interface [polypeptide binding]; other site 758793002287 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 758793002288 putative dimerization interface [polypeptide binding]; other site 758793002289 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 758793002290 gating phenylalanine in ion channel; other site 758793002291 Domain of unknown function (DUF305); Region: DUF305; cl17794 758793002292 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 758793002293 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 758793002294 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 758793002295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 758793002296 Integrase core domain; Region: rve; pfam00665 758793002297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 758793002298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793002299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793002300 DNA binding residues [nucleotide binding] 758793002301 dimerization interface [polypeptide binding]; other site 758793002302 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 758793002303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 758793002304 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 758793002305 active site 758793002306 metal binding site [ion binding]; metal-binding site 758793002307 interdomain interaction site; other site 758793002308 Domain of unknown function (DUF927); Region: DUF927; pfam06048 758793002309 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 758793002310 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 758793002311 active site 758793002312 Int/Topo IB signature motif; other site 758793002313 enterobactin exporter EntS; Provisional; Region: PRK10489 758793002314 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 758793002315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793002316 FeS/SAM binding site; other site 758793002317 HemN C-terminal domain; Region: HemN_C; pfam06969 758793002318 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 758793002319 active site 758793002320 dimerization interface [polypeptide binding]; other site 758793002321 ribonuclease PH; Reviewed; Region: rph; PRK00173 758793002322 Ribonuclease PH; Region: RNase_PH_bact; cd11362 758793002323 hexamer interface [polypeptide binding]; other site 758793002324 active site 758793002325 hypothetical protein; Provisional; Region: PRK11820 758793002326 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 758793002327 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 758793002328 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 758793002329 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 758793002330 catalytic site [active] 758793002331 G-X2-G-X-G-K; other site 758793002332 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 758793002333 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 758793002334 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758793002335 Zn2+ binding site [ion binding]; other site 758793002336 Mg2+ binding site [ion binding]; other site 758793002337 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 758793002338 synthetase active site [active] 758793002339 NTP binding site [chemical binding]; other site 758793002340 metal binding site [ion binding]; metal-binding site 758793002341 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 758793002342 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 758793002343 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 758793002344 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 758793002345 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 758793002346 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 758793002347 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793002348 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793002349 trimer interface [polypeptide binding]; other site 758793002350 eyelet of channel; other site 758793002351 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 758793002352 active site 758793002353 catalytic site [active] 758793002354 substrate binding site [chemical binding]; other site 758793002355 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 758793002356 GIY-YIG motif/motif A; other site 758793002357 active site 758793002358 catalytic site [active] 758793002359 putative DNA binding site [nucleotide binding]; other site 758793002360 metal binding site [ion binding]; metal-binding site 758793002361 chorismate mutase; Provisional; Region: PRK09269 758793002362 Chorismate mutase type II; Region: CM_2; cl00693 758793002363 fructose-1,6-bisphosphatase family protein; Region: PLN02628 758793002364 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 758793002365 AMP binding site [chemical binding]; other site 758793002366 metal binding site [ion binding]; metal-binding site 758793002367 active site 758793002368 aminopeptidase N; Provisional; Region: pepN; PRK14015 758793002369 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 758793002370 active site 758793002371 Zn binding site [ion binding]; other site 758793002372 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 758793002373 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 758793002374 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 758793002375 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 758793002376 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 758793002377 active site 758793002378 metal-binding site 758793002379 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 758793002380 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793002381 tetramer interface [polypeptide binding]; other site 758793002382 active site 758793002383 Mg2+/Mn2+ binding site [ion binding]; other site 758793002384 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 758793002385 active site 758793002386 metal-binding site 758793002387 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793002388 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 758793002389 PYR/PP interface [polypeptide binding]; other site 758793002390 dimer interface [polypeptide binding]; other site 758793002391 TPP binding site [chemical binding]; other site 758793002392 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 758793002393 TPP-binding site; other site 758793002394 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758793002395 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 758793002396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793002397 catalytic residue [active] 758793002398 guanine deaminase; Provisional; Region: PRK09228 758793002399 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 758793002400 active site 758793002401 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 758793002402 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 758793002403 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 758793002404 active site 758793002405 purine riboside binding site [chemical binding]; other site 758793002406 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 758793002407 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 758793002408 XdhC Rossmann domain; Region: XdhC_C; pfam13478 758793002409 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 758793002410 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793002411 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793002412 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 758793002413 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793002414 catalytic loop [active] 758793002415 iron binding site [ion binding]; other site 758793002416 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793002417 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 758793002418 disulfide bond formation protein B; Provisional; Region: PRK02110 758793002419 amidase; Provisional; Region: PRK07056 758793002420 Amidase; Region: Amidase; cl11426 758793002421 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 758793002422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793002423 FeS/SAM binding site; other site 758793002424 HemN C-terminal domain; Region: HemN_C; pfam06969 758793002425 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 758793002426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793002427 S-adenosylmethionine binding site [chemical binding]; other site 758793002428 YGGT family; Region: YGGT; pfam02325 758793002429 YGGT family; Region: YGGT; pfam02325 758793002430 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 758793002431 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 758793002432 tetramer interface [polypeptide binding]; other site 758793002433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793002434 catalytic residue [active] 758793002435 LysE type translocator; Region: LysE; cl00565 758793002436 L-asparaginase II; Region: Asparaginase_II; pfam06089 758793002437 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 758793002438 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 758793002439 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793002440 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793002441 catalytic residue [active] 758793002442 aminotransferase; Validated; Region: PRK07337 758793002443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793002444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793002445 homodimer interface [polypeptide binding]; other site 758793002446 catalytic residue [active] 758793002447 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 758793002448 putative RNA binding site [nucleotide binding]; other site 758793002449 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 758793002450 homopentamer interface [polypeptide binding]; other site 758793002451 active site 758793002452 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 758793002453 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 758793002454 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 758793002455 dimerization interface [polypeptide binding]; other site 758793002456 active site 758793002457 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 758793002458 Lumazine binding domain; Region: Lum_binding; pfam00677 758793002459 Lumazine binding domain; Region: Lum_binding; pfam00677 758793002460 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 758793002461 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 758793002462 catalytic motif [active] 758793002463 Zn binding site [ion binding]; other site 758793002464 RibD C-terminal domain; Region: RibD_C; cl17279 758793002465 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 758793002466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793002467 inhibitor-cofactor binding pocket; inhibition site 758793002468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793002469 catalytic residue [active] 758793002470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793002471 putative substrate translocation pore; other site 758793002472 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 758793002473 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793002474 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 758793002475 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 758793002476 Walker A/P-loop; other site 758793002477 ATP binding site [chemical binding]; other site 758793002478 Q-loop/lid; other site 758793002479 ABC transporter signature motif; other site 758793002480 Walker B; other site 758793002481 D-loop; other site 758793002482 H-loop/switch region; other site 758793002483 TOBE domain; Region: TOBE; pfam03459 758793002484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758793002485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793002486 dimer interface [polypeptide binding]; other site 758793002487 conserved gate region; other site 758793002488 putative PBP binding loops; other site 758793002489 ABC-ATPase subunit interface; other site 758793002490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793002491 dimer interface [polypeptide binding]; other site 758793002492 conserved gate region; other site 758793002493 putative PBP binding loops; other site 758793002494 ABC-ATPase subunit interface; other site 758793002495 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 758793002496 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 758793002497 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 758793002498 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 758793002499 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 758793002500 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 758793002501 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 758793002502 putative active site [active] 758793002503 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 758793002504 glucokinase; Provisional; Region: glk; PRK00292 758793002505 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758793002506 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758793002507 putative active site [active] 758793002508 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793002509 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793002510 trimer interface [polypeptide binding]; other site 758793002511 eyelet of channel; other site 758793002512 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793002513 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793002514 trimer interface [polypeptide binding]; other site 758793002515 eyelet of channel; other site 758793002516 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 758793002517 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793002518 Walker A/P-loop; other site 758793002519 ATP binding site [chemical binding]; other site 758793002520 Q-loop/lid; other site 758793002521 ABC transporter signature motif; other site 758793002522 Walker B; other site 758793002523 D-loop; other site 758793002524 H-loop/switch region; other site 758793002525 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793002527 dimer interface [polypeptide binding]; other site 758793002528 conserved gate region; other site 758793002529 putative PBP binding loops; other site 758793002530 ABC-ATPase subunit interface; other site 758793002531 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793002533 dimer interface [polypeptide binding]; other site 758793002534 conserved gate region; other site 758793002535 putative PBP binding loops; other site 758793002536 ABC-ATPase subunit interface; other site 758793002537 Pirin-related protein [General function prediction only]; Region: COG1741 758793002538 Pirin; Region: Pirin; pfam02678 758793002539 Heavy-metal resistance; Region: Metal_resist; pfam13801 758793002540 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793002541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793002542 active site 758793002543 phosphorylation site [posttranslational modification] 758793002544 intermolecular recognition site; other site 758793002545 dimerization interface [polypeptide binding]; other site 758793002546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793002547 DNA binding site [nucleotide binding] 758793002548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793002549 dimerization interface [polypeptide binding]; other site 758793002550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 758793002551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793002552 dimer interface [polypeptide binding]; other site 758793002553 phosphorylation site [posttranslational modification] 758793002554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793002555 ATP binding site [chemical binding]; other site 758793002556 Mg2+ binding site [ion binding]; other site 758793002557 G-X-G motif; other site 758793002558 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 758793002559 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793002560 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793002561 metal binding site [ion binding]; metal-binding site 758793002562 active site 758793002563 I-site; other site 758793002564 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 758793002565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793002566 dimer interface [polypeptide binding]; other site 758793002567 conserved gate region; other site 758793002568 putative PBP binding loops; other site 758793002569 ABC-ATPase subunit interface; other site 758793002570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793002571 dimer interface [polypeptide binding]; other site 758793002572 conserved gate region; other site 758793002573 putative PBP binding loops; other site 758793002574 ABC-ATPase subunit interface; other site 758793002575 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793002576 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793002577 Walker A/P-loop; other site 758793002578 ATP binding site [chemical binding]; other site 758793002579 Q-loop/lid; other site 758793002580 ABC transporter signature motif; other site 758793002581 Walker B; other site 758793002582 D-loop; other site 758793002583 H-loop/switch region; other site 758793002584 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 758793002585 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 758793002586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793002587 Walker A motif; other site 758793002588 ATP binding site [chemical binding]; other site 758793002589 Walker B motif; other site 758793002590 arginine finger; other site 758793002591 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793002592 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 758793002593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793002594 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 758793002595 active site 758793002596 phosphorylation site [posttranslational modification] 758793002597 intermolecular recognition site; other site 758793002598 dimerization interface [polypeptide binding]; other site 758793002599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793002600 Walker A motif; other site 758793002601 ATP binding site [chemical binding]; other site 758793002602 Walker B motif; other site 758793002603 arginine finger; other site 758793002604 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793002605 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 758793002606 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 758793002607 active site 758793002608 homotetramer interface [polypeptide binding]; other site 758793002609 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 758793002610 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 758793002611 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 758793002612 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 758793002613 BON domain; Region: BON; pfam04972 758793002614 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 758793002615 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 758793002616 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 758793002617 intracellular protease, PfpI family; Region: PfpI; TIGR01382 758793002618 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 758793002619 proposed catalytic triad [active] 758793002620 conserved cys residue [active] 758793002621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793002622 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793002623 putative substrate translocation pore; other site 758793002624 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 758793002625 substrate binding site [chemical binding]; other site 758793002626 PAS domain; Region: PAS_9; pfam13426 758793002627 PAS domain; Region: PAS_9; pfam13426 758793002628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793002629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793002630 metal binding site [ion binding]; metal-binding site 758793002631 active site 758793002632 I-site; other site 758793002633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793002634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793002635 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 758793002636 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 758793002637 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 758793002638 shikimate binding site; other site 758793002639 NAD(P) binding site [chemical binding]; other site 758793002640 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 758793002641 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 758793002642 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 758793002643 dimer interface [polypeptide binding]; other site 758793002644 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 758793002645 active site 758793002646 Fe binding site [ion binding]; other site 758793002647 Methyltransferase domain; Region: Methyltransf_31; pfam13847 758793002648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793002649 S-adenosylmethionine binding site [chemical binding]; other site 758793002650 Rubredoxin [Energy production and conversion]; Region: COG1773 758793002651 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 758793002652 iron binding site [ion binding]; other site 758793002653 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 758793002654 ABC transporter ATPase component; Reviewed; Region: PRK11147 758793002655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793002656 Walker A/P-loop; other site 758793002657 ATP binding site [chemical binding]; other site 758793002658 Q-loop/lid; other site 758793002659 ABC transporter signature motif; other site 758793002660 Walker B; other site 758793002661 D-loop; other site 758793002662 H-loop/switch region; other site 758793002663 ABC transporter; Region: ABC_tran_2; pfam12848 758793002664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793002665 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 758793002666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793002667 ATP binding site [chemical binding]; other site 758793002668 Mg2+ binding site [ion binding]; other site 758793002669 G-X-G motif; other site 758793002670 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 758793002671 anchoring element; other site 758793002672 dimer interface [polypeptide binding]; other site 758793002673 ATP binding site [chemical binding]; other site 758793002674 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 758793002675 active site 758793002676 metal binding site [ion binding]; metal-binding site 758793002677 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 758793002678 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 758793002679 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 758793002680 CAP-like domain; other site 758793002681 active site 758793002682 primary dimer interface [polypeptide binding]; other site 758793002683 Predicted integral membrane protein [Function unknown]; Region: COG5615 758793002684 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793002685 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793002686 metal binding site [ion binding]; metal-binding site 758793002687 active site 758793002688 I-site; other site 758793002689 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793002690 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 758793002691 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 758793002692 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 758793002693 homotrimer interaction site [polypeptide binding]; other site 758793002694 putative active site [active] 758793002695 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 758793002696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793002697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793002698 homodimer interface [polypeptide binding]; other site 758793002699 catalytic residue [active] 758793002700 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 758793002701 EamA-like transporter family; Region: EamA; pfam00892 758793002702 EamA-like transporter family; Region: EamA; pfam00892 758793002703 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 758793002704 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793002705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793002706 DNA-binding site [nucleotide binding]; DNA binding site 758793002707 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793002708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793002709 homodimer interface [polypeptide binding]; other site 758793002710 catalytic residue [active] 758793002711 heat shock protein 90; Provisional; Region: PRK05218 758793002712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793002713 ATP binding site [chemical binding]; other site 758793002714 Mg2+ binding site [ion binding]; other site 758793002715 G-X-G motif; other site 758793002716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002717 binding surface 758793002718 TPR motif; other site 758793002719 TPR repeat; Region: TPR_11; pfam13414 758793002720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002721 binding surface 758793002722 TPR motif; other site 758793002723 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 758793002724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002725 binding surface 758793002726 TPR motif; other site 758793002727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793002728 heat shock protein 90; Provisional; Region: PRK05218 758793002729 heat shock protein 90; Provisional; Region: PRK05218 758793002730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002731 binding surface 758793002732 TPR motif; other site 758793002733 TPR repeat; Region: TPR_11; pfam13414 758793002734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002735 binding surface 758793002736 TPR motif; other site 758793002737 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 758793002738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002739 binding surface 758793002740 TPR motif; other site 758793002741 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793002742 binding surface 758793002743 TPR motif; other site 758793002744 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793002745 Chorismate lyase; Region: Chor_lyase; cl01230 758793002746 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 758793002747 putative active site [active] 758793002748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793002749 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 758793002750 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 758793002751 Na binding site [ion binding]; other site 758793002752 Predicted membrane protein [Function unknown]; Region: COG1289 758793002753 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793002754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793002755 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 758793002756 dimer interface [polypeptide binding]; other site 758793002757 transaldolase-like protein; Provisional; Region: PTZ00411 758793002758 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 758793002759 active site 758793002760 dimer interface [polypeptide binding]; other site 758793002761 catalytic residue [active] 758793002762 Benzoate membrane transport protein; Region: BenE; pfam03594 758793002763 benzoate transporter; Region: benE; TIGR00843 758793002764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 758793002765 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758793002766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758793002767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793002768 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 758793002769 Walker A motif; other site 758793002770 ATP binding site [chemical binding]; other site 758793002771 Walker B motif; other site 758793002772 arginine finger; other site 758793002773 Cytochrome c; Region: Cytochrom_C; cl11414 758793002774 Cytochrome c; Region: Cytochrom_C; cl11414 758793002775 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793002776 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 758793002777 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 758793002778 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 758793002779 minor groove reading motif; other site 758793002780 helix-hairpin-helix signature motif; other site 758793002781 substrate binding pocket [chemical binding]; other site 758793002782 active site 758793002783 ferredoxin; Provisional; Region: PRK06991 758793002784 Putative Fe-S cluster; Region: FeS; pfam04060 758793002785 4Fe-4S binding domain; Region: Fer4; pfam00037 758793002786 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 758793002787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793002788 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 758793002789 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 758793002790 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 758793002791 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 758793002792 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 758793002793 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 758793002794 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 758793002795 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 758793002796 Cl binding site [ion binding]; other site 758793002797 oligomer interface [polypeptide binding]; other site 758793002798 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 758793002799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 758793002800 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 758793002801 META domain; Region: META; pfam03724 758793002802 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 758793002803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793002804 ATP-grasp domain; Region: ATP-grasp; pfam02222 758793002805 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 758793002806 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 758793002807 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758793002808 ATP binding site [chemical binding]; other site 758793002809 Mg++ binding site [ion binding]; other site 758793002810 motif III; other site 758793002811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793002812 nucleotide binding region [chemical binding]; other site 758793002813 ATP-binding site [chemical binding]; other site 758793002814 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 758793002815 active site 758793002816 HIGH motif; other site 758793002817 nucleotide binding site [chemical binding]; other site 758793002818 active site 758793002819 KMSKS motif; other site 758793002820 rhodanese superfamily protein; Provisional; Region: PRK05320 758793002821 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 758793002822 active site residue [active] 758793002823 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 758793002824 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 758793002825 putative active site [active] 758793002826 putative PHP Thumb interface [polypeptide binding]; other site 758793002827 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 758793002828 generic binding surface II; other site 758793002829 generic binding surface I; other site 758793002830 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 758793002831 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793002832 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 758793002833 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793002834 putative metal binding site; other site 758793002835 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 758793002836 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 758793002837 active site 758793002838 O-Antigen ligase; Region: Wzy_C; pfam04932 758793002839 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 758793002840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758793002841 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 758793002842 Walker A/P-loop; other site 758793002843 ATP binding site [chemical binding]; other site 758793002844 Q-loop/lid; other site 758793002845 ABC transporter signature motif; other site 758793002846 Walker B; other site 758793002847 D-loop; other site 758793002848 H-loop/switch region; other site 758793002849 ribonuclease G; Provisional; Region: PRK11712 758793002850 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 758793002851 homodimer interface [polypeptide binding]; other site 758793002852 oligonucleotide binding site [chemical binding]; other site 758793002853 Maf-like protein; Region: Maf; pfam02545 758793002854 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 758793002855 active site 758793002856 dimer interface [polypeptide binding]; other site 758793002857 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 758793002858 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 758793002859 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 758793002860 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 758793002861 active site 758793002862 (T/H)XGH motif; other site 758793002863 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 758793002864 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 758793002865 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 758793002866 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 758793002867 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 758793002868 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 758793002869 hypothetical protein; Validated; Region: PRK00110 758793002870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793002871 active site 758793002872 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 758793002873 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 758793002874 putative NAD(P) binding site [chemical binding]; other site 758793002875 putative active site [active] 758793002876 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 758793002877 substrate binding site [chemical binding]; other site 758793002878 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 758793002879 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 758793002880 NADP binding site [chemical binding]; other site 758793002881 dimer interface [polypeptide binding]; other site 758793002882 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 758793002883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793002884 active site 758793002885 phosphorylation site [posttranslational modification] 758793002886 intermolecular recognition site; other site 758793002887 dimerization interface [polypeptide binding]; other site 758793002888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793002889 DNA binding site [nucleotide binding] 758793002890 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 758793002891 NADH(P)-binding; Region: NAD_binding_10; pfam13460 758793002892 NAD(P) binding site [chemical binding]; other site 758793002893 putative active site [active] 758793002894 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 758793002895 Protein export membrane protein; Region: SecD_SecF; cl14618 758793002896 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 758793002897 Protein export membrane protein; Region: SecD_SecF; cl14618 758793002898 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793002899 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793002900 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793002901 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793002902 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793002903 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793002904 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793002905 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793002906 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 758793002907 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793002908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793002909 putative DNA binding site [nucleotide binding]; other site 758793002910 putative Zn2+ binding site [ion binding]; other site 758793002911 AsnC family; Region: AsnC_trans_reg; pfam01037 758793002912 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 758793002913 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793002914 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 758793002915 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 758793002916 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 758793002917 Family description; Region: UvrD_C_2; pfam13538 758793002918 AAA domain; Region: AAA_30; pfam13604 758793002919 Family description; Region: UvrD_C_2; pfam13538 758793002920 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 758793002921 hypothetical protein; Provisional; Region: PRK09256 758793002922 EamA-like transporter family; Region: EamA; pfam00892 758793002923 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758793002924 EamA-like transporter family; Region: EamA; pfam00892 758793002925 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 758793002926 L-lactate permease; Region: Lactate_perm; cl00701 758793002927 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 758793002928 ThiC-associated domain; Region: ThiC-associated; pfam13667 758793002929 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 758793002930 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 758793002931 EamA-like transporter family; Region: EamA; pfam00892 758793002932 EamA-like transporter family; Region: EamA; pfam00892 758793002933 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 758793002934 Predicted small secreted protein [Function unknown]; Region: COG5510 758793002935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793002936 Histidine kinase; Region: HisKA_3; pfam07730 758793002937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793002938 ATP binding site [chemical binding]; other site 758793002939 Mg2+ binding site [ion binding]; other site 758793002940 G-X-G motif; other site 758793002941 Ferritin-like domain; Region: Ferritin; pfam00210 758793002942 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 758793002943 dinuclear metal binding motif [ion binding]; other site 758793002944 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793002946 active site 758793002947 phosphorylation site [posttranslational modification] 758793002948 intermolecular recognition site; other site 758793002949 dimerization interface [polypeptide binding]; other site 758793002950 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793002951 DNA binding residues [nucleotide binding] 758793002952 dimerization interface [polypeptide binding]; other site 758793002953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793002954 Response regulator receiver domain; Region: Response_reg; pfam00072 758793002955 active site 758793002956 phosphorylation site [posttranslational modification] 758793002957 intermolecular recognition site; other site 758793002958 dimerization interface [polypeptide binding]; other site 758793002959 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 758793002960 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758793002961 active site 758793002962 metal binding site [ion binding]; metal-binding site 758793002963 hexamer interface [polypeptide binding]; other site 758793002964 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 758793002965 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 758793002966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793002967 ATP binding site [chemical binding]; other site 758793002968 Mg2+ binding site [ion binding]; other site 758793002969 G-X-G motif; other site 758793002970 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 758793002971 active site 758793002972 CoA binding site [chemical binding]; other site 758793002973 substrate binding site [chemical binding]; other site 758793002974 trimer interface [polypeptide binding]; other site 758793002975 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 758793002976 active site 758793002977 metal binding site [ion binding]; metal-binding site 758793002978 homotetramer interface [polypeptide binding]; other site 758793002979 proline/glycine betaine transporter; Provisional; Region: PRK10642 758793002980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793002981 putative substrate translocation pore; other site 758793002982 oxidative damage protection protein; Provisional; Region: PRK05408 758793002983 N-acetylglutamate synthase; Validated; Region: PRK05279 758793002984 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 758793002985 putative feedback inhibition sensing region; other site 758793002986 putative nucleotide binding site [chemical binding]; other site 758793002987 putative substrate binding site [chemical binding]; other site 758793002988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793002989 Coenzyme A binding pocket [chemical binding]; other site 758793002990 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 758793002991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793002992 ATP binding site [chemical binding]; other site 758793002993 putative Mg++ binding site [ion binding]; other site 758793002994 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793002995 nucleotide binding region [chemical binding]; other site 758793002996 ATP-binding site [chemical binding]; other site 758793002997 Helicase associated domain (HA2); Region: HA2; pfam04408 758793002998 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 758793002999 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 758793003000 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 758793003001 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 758793003002 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 758793003003 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 758793003004 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 758793003005 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 758793003006 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 758793003007 putative MPT binding site; other site 758793003008 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 758793003009 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 758793003010 active site residue [active] 758793003011 glutamine synthetase; Provisional; Region: glnA; PRK09469 758793003012 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 758793003013 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 758793003014 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 758793003015 PAS domain; Region: PAS; smart00091 758793003016 putative active site [active] 758793003017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793003018 dimer interface [polypeptide binding]; other site 758793003019 phosphorylation site [posttranslational modification] 758793003020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793003021 ATP binding site [chemical binding]; other site 758793003022 Mg2+ binding site [ion binding]; other site 758793003023 G-X-G motif; other site 758793003024 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 758793003025 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793003026 active site 758793003027 phosphorylation site [posttranslational modification] 758793003028 intermolecular recognition site; other site 758793003029 dimerization interface [polypeptide binding]; other site 758793003030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793003031 Walker A motif; other site 758793003032 ATP binding site [chemical binding]; other site 758793003033 Walker B motif; other site 758793003034 arginine finger; other site 758793003035 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793003036 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 758793003037 putative catalytic site [active] 758793003038 putative phosphate binding site [ion binding]; other site 758793003039 active site 758793003040 metal binding site A [ion binding]; metal-binding site 758793003041 DNA binding site [nucleotide binding] 758793003042 putative AP binding site [nucleotide binding]; other site 758793003043 putative metal binding site B [ion binding]; other site 758793003044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793003045 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758793003046 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758793003047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793003048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003049 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 758793003050 dimerization interface [polypeptide binding]; other site 758793003051 substrate binding pocket [chemical binding]; other site 758793003052 Predicted amidohydrolase [General function prediction only]; Region: COG0388 758793003053 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 758793003054 active site 758793003055 catalytic triad [active] 758793003056 dimer interface [polypeptide binding]; other site 758793003057 cytosine deaminase; Validated; Region: PRK07572 758793003058 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 758793003059 active site 758793003060 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 758793003061 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 758793003062 active site 758793003063 Zn binding site [ion binding]; other site 758793003064 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 758793003065 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 758793003066 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 758793003067 homodimer interface [polypeptide binding]; other site 758793003068 NADP binding site [chemical binding]; other site 758793003069 substrate binding site [chemical binding]; other site 758793003070 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 758793003071 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 758793003072 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 758793003073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793003074 active site 758793003075 phosphorylation site [posttranslational modification] 758793003076 intermolecular recognition site; other site 758793003077 dimerization interface [polypeptide binding]; other site 758793003078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793003079 DNA binding residues [nucleotide binding] 758793003080 dimerization interface [polypeptide binding]; other site 758793003081 PAS domain S-box; Region: sensory_box; TIGR00229 758793003082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793003083 putative active site [active] 758793003084 heme pocket [chemical binding]; other site 758793003085 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 758793003086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793003087 dimer interface [polypeptide binding]; other site 758793003088 phosphorylation site [posttranslational modification] 758793003089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793003090 ATP binding site [chemical binding]; other site 758793003091 Mg2+ binding site [ion binding]; other site 758793003092 G-X-G motif; other site 758793003093 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 758793003094 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 758793003095 dimer interface [polypeptide binding]; other site 758793003096 TPP-binding site [chemical binding]; other site 758793003097 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 758793003098 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 758793003099 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793003100 E3 interaction surface; other site 758793003101 lipoyl attachment site [posttranslational modification]; other site 758793003102 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793003103 E3 interaction surface; other site 758793003104 lipoyl attachment site [posttranslational modification]; other site 758793003105 e3 binding domain; Region: E3_binding; pfam02817 758793003106 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 758793003107 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793003108 E3 interaction surface; other site 758793003109 lipoyl attachment site [posttranslational modification]; other site 758793003110 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793003111 E3 interaction surface; other site 758793003112 lipoyl attachment site [posttranslational modification]; other site 758793003113 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 758793003114 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793003115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793003116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793003117 Phasin protein; Region: Phasin_2; pfam09361 758793003118 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 758793003119 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 758793003120 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793003121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793003122 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793003123 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 758793003124 Cysteine-rich domain; Region: CCG; pfam02754 758793003125 Cysteine-rich domain; Region: CCG; pfam02754 758793003126 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 758793003127 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 758793003128 4Fe-4S binding domain; Region: Fer4; pfam00037 758793003129 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 758793003130 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 758793003131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793003132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003133 homodimer interface [polypeptide binding]; other site 758793003134 catalytic residue [active] 758793003135 excinuclease ABC subunit B; Provisional; Region: PRK05298 758793003136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793003137 ATP binding site [chemical binding]; other site 758793003138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793003139 nucleotide binding region [chemical binding]; other site 758793003140 ATP-binding site [chemical binding]; other site 758793003141 Ultra-violet resistance protein B; Region: UvrB; pfam12344 758793003142 UvrB/uvrC motif; Region: UVR; pfam02151 758793003143 Fe2+ transport protein; Region: Iron_transport; pfam10634 758793003144 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 758793003145 Iron permease FTR1 family; Region: FTR1; cl00475 758793003146 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 758793003147 4Fe-4S binding domain; Region: Fer4_5; pfam12801 758793003148 Domain of unknown function (DUF336); Region: DUF336; cl01249 758793003149 Hemin uptake protein hemP; Region: hemP; pfam10636 758793003150 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 758793003151 putative hydrophobic ligand binding site [chemical binding]; other site 758793003152 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 758793003153 Pirin-related protein [General function prediction only]; Region: COG1741 758793003154 Pirin; Region: Pirin; pfam02678 758793003155 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 758793003156 LysR family transcriptional regulator; Provisional; Region: PRK14997 758793003157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003158 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 758793003159 putative effector binding pocket; other site 758793003160 putative dimerization interface [polypeptide binding]; other site 758793003161 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 758793003162 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 758793003163 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 758793003164 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 758793003165 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 758793003166 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 758793003167 glutamate racemase; Provisional; Region: PRK00865 758793003168 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 758793003169 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 758793003170 heme binding site [chemical binding]; other site 758793003171 ferroxidase pore; other site 758793003172 ferroxidase diiron center [ion binding]; other site 758793003173 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 758793003174 Fumarase C-terminus; Region: Fumerase_C; pfam05683 758793003175 hypothetical protein; Provisional; Region: PRK05208 758793003176 EamA-like transporter family; Region: EamA; pfam00892 758793003177 EamA-like transporter family; Region: EamA; pfam00892 758793003178 acetyl-CoA synthetase; Provisional; Region: PRK00174 758793003179 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 758793003180 active site 758793003181 CoA binding site [chemical binding]; other site 758793003182 acyl-activating enzyme (AAE) consensus motif; other site 758793003183 AMP binding site [chemical binding]; other site 758793003184 acetate binding site [chemical binding]; other site 758793003185 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 758793003186 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 758793003187 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 758793003188 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 758793003189 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 758793003190 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 758793003191 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 758793003192 PRC-barrel domain; Region: PRC; pfam05239 758793003193 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 758793003194 RNA/DNA hybrid binding site [nucleotide binding]; other site 758793003195 active site 758793003196 short chain dehydrogenase; Provisional; Region: PRK07023 758793003197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793003198 NAD(P) binding site [chemical binding]; other site 758793003199 active site 758793003200 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793003201 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793003202 trimer interface [polypeptide binding]; other site 758793003203 eyelet of channel; other site 758793003204 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793003205 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 758793003206 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793003207 catalytic loop [active] 758793003208 iron binding site [ion binding]; other site 758793003209 Uncharacterized conserved protein [Function unknown]; Region: COG1739 758793003210 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 758793003211 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 758793003212 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 758793003213 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 758793003214 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 758793003215 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 758793003216 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793003217 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793003218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793003219 dimer interface [polypeptide binding]; other site 758793003220 conserved gate region; other site 758793003221 putative PBP binding loops; other site 758793003222 ABC-ATPase subunit interface; other site 758793003223 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793003224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793003225 dimer interface [polypeptide binding]; other site 758793003226 conserved gate region; other site 758793003227 putative PBP binding loops; other site 758793003228 ABC-ATPase subunit interface; other site 758793003229 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 758793003230 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793003231 Walker A/P-loop; other site 758793003232 ATP binding site [chemical binding]; other site 758793003233 Q-loop/lid; other site 758793003234 ABC transporter signature motif; other site 758793003235 Walker B; other site 758793003236 D-loop; other site 758793003237 H-loop/switch region; other site 758793003238 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793003239 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 758793003240 conserved cys residue [active] 758793003241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793003242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793003243 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 758793003244 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793003245 inhibitor-cofactor binding pocket; inhibition site 758793003246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003247 catalytic residue [active] 758793003248 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 758793003249 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 758793003250 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 758793003251 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 758793003252 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 758793003253 NAD(P) binding site [chemical binding]; other site 758793003254 catalytic residues [active] 758793003255 succinylarginine dihydrolase; Provisional; Region: PRK13281 758793003256 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 758793003257 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 758793003258 putative active site [active] 758793003259 Zn binding site [ion binding]; other site 758793003260 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 758793003261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793003262 substrate binding pocket [chemical binding]; other site 758793003263 membrane-bound complex binding site; other site 758793003264 hinge residues; other site 758793003265 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793003266 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793003267 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 758793003268 Fusaric acid resistance protein family; Region: FUSC; pfam04632 758793003269 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793003270 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793003271 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793003272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003273 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793003274 putative effector binding pocket; other site 758793003275 dimerization interface [polypeptide binding]; other site 758793003276 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 758793003277 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758793003278 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 758793003279 putative active site [active] 758793003280 putative metal binding site [ion binding]; other site 758793003281 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793003282 FAD binding domain; Region: FAD_binding_4; pfam01565 758793003283 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 758793003284 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758793003285 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793003286 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 758793003287 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 758793003288 Protein of unknown function (DUF962); Region: DUF962; cl01879 758793003289 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793003290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793003291 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 758793003292 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 758793003293 homodimer interface [polypeptide binding]; other site 758793003294 substrate-cofactor binding pocket; other site 758793003295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003296 catalytic residue [active] 758793003297 FOG: CBS domain [General function prediction only]; Region: COG0517 758793003298 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 758793003299 lysophospholipid transporter LplT; Provisional; Region: PRK11195 758793003300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793003301 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758793003302 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758793003303 putative acyl-acceptor binding pocket; other site 758793003304 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 758793003305 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 758793003306 Tetramer interface [polypeptide binding]; other site 758793003307 active site 758793003308 FMN-binding site [chemical binding]; other site 758793003309 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 758793003310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793003311 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 758793003312 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 758793003313 short chain dehydrogenase; Provisional; Region: PRK06949 758793003314 classical (c) SDRs; Region: SDR_c; cd05233 758793003315 NAD(P) binding site [chemical binding]; other site 758793003316 active site 758793003317 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758793003318 active site 758793003319 PAS domain; Region: PAS_9; pfam13426 758793003320 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793003321 putative active site [active] 758793003322 heme pocket [chemical binding]; other site 758793003323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793003324 DNA binding residues [nucleotide binding] 758793003325 dimerization interface [polypeptide binding]; other site 758793003326 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 758793003327 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 758793003328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793003329 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793003330 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 758793003331 homotrimer interaction site [polypeptide binding]; other site 758793003332 putative active site [active] 758793003333 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 758793003334 HD domain; Region: HD_4; pfam13328 758793003335 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 758793003336 synthetase active site [active] 758793003337 NTP binding site [chemical binding]; other site 758793003338 metal binding site [ion binding]; metal-binding site 758793003339 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 758793003340 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 758793003341 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 758793003342 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 758793003343 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 758793003344 active site 758793003345 dimer interface [polypeptide binding]; other site 758793003346 motif 1; other site 758793003347 motif 2; other site 758793003348 motif 3; other site 758793003349 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 758793003350 anticodon binding site; other site 758793003351 translation initiation factor IF-3; Region: infC; TIGR00168 758793003352 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 758793003353 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 758793003354 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 758793003355 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 758793003356 L21 binding site [polypeptide binding]; other site 758793003357 23S rRNA binding site [nucleotide binding]; other site 758793003358 L13 binding site [polypeptide binding]; other site 758793003359 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 758793003360 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 758793003361 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 758793003362 dimer interface [polypeptide binding]; other site 758793003363 motif 1; other site 758793003364 active site 758793003365 motif 2; other site 758793003366 motif 3; other site 758793003367 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 758793003368 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 758793003369 putative tRNA-binding site [nucleotide binding]; other site 758793003370 B3/4 domain; Region: B3_4; pfam03483 758793003371 tRNA synthetase B5 domain; Region: B5; smart00874 758793003372 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 758793003373 dimer interface [polypeptide binding]; other site 758793003374 motif 1; other site 758793003375 motif 3; other site 758793003376 motif 2; other site 758793003377 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 758793003378 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 758793003379 IHF dimer interface [polypeptide binding]; other site 758793003380 IHF - DNA interface [nucleotide binding]; other site 758793003381 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 758793003382 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758793003383 DNA binding residues [nucleotide binding] 758793003384 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 758793003385 putative NAD(P) binding site [chemical binding]; other site 758793003386 homodimer interface [polypeptide binding]; other site 758793003387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793003388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003389 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793003390 putative effector binding pocket; other site 758793003391 dimerization interface [polypeptide binding]; other site 758793003392 Predicted membrane protein [Function unknown]; Region: COG2259 758793003393 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 758793003394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003395 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 758793003396 substrate binding pocket [chemical binding]; other site 758793003397 dimerization interface [polypeptide binding]; other site 758793003398 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 758793003399 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793003400 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793003401 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 758793003402 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 758793003403 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 758793003404 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793003405 dimer interface [polypeptide binding]; other site 758793003406 active site 758793003407 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 758793003408 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 758793003409 tetramer interface [polypeptide binding]; other site 758793003410 active site 758793003411 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 758793003412 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 758793003413 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 758793003414 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 758793003415 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 758793003416 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 758793003417 Uncharacterized conserved protein [Function unknown]; Region: COG1359 758793003418 malate synthase A; Region: malate_syn_A; TIGR01344 758793003419 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 758793003420 active site 758793003421 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 758793003422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793003423 motif II; other site 758793003424 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793003425 putative effector binding pocket; other site 758793003426 dimerization interface [polypeptide binding]; other site 758793003427 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 758793003428 Ligand Binding Site [chemical binding]; other site 758793003429 isocitrate lyase; Provisional; Region: PRK15063 758793003430 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793003431 tetramer interface [polypeptide binding]; other site 758793003432 active site 758793003433 Mg2+/Mn2+ binding site [ion binding]; other site 758793003434 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758793003435 DEAD-like helicases superfamily; Region: DEXDc; smart00487 758793003436 ATP binding site [chemical binding]; other site 758793003437 Mg++ binding site [ion binding]; other site 758793003438 motif III; other site 758793003439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793003440 nucleotide binding region [chemical binding]; other site 758793003441 ATP-binding site [chemical binding]; other site 758793003442 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 758793003443 acyl-CoA binding pocket [chemical binding]; other site 758793003444 CoA binding site [chemical binding]; other site 758793003445 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 758793003446 Glycoprotease family; Region: Peptidase_M22; pfam00814 758793003447 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 758793003448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793003449 Coenzyme A binding pocket [chemical binding]; other site 758793003450 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 758793003451 Fe-S cluster binding site [ion binding]; other site 758793003452 active site 758793003453 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 758793003454 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 758793003455 dimer interface [polypeptide binding]; other site 758793003456 substrate binding site [chemical binding]; other site 758793003457 ATP binding site [chemical binding]; other site 758793003458 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 758793003459 thiamine phosphate binding site [chemical binding]; other site 758793003460 active site 758793003461 pyrophosphate binding site [ion binding]; other site 758793003462 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 758793003463 substrate binding site [chemical binding]; other site 758793003464 multimerization interface [polypeptide binding]; other site 758793003465 ATP binding site [chemical binding]; other site 758793003466 lysophospholipid transporter LplT; Provisional; Region: PRK11195 758793003467 alanine racemase; Reviewed; Region: dadX; PRK03646 758793003468 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 758793003469 active site 758793003470 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758793003471 substrate binding site [chemical binding]; other site 758793003472 catalytic residues [active] 758793003473 dimer interface [polypeptide binding]; other site 758793003474 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793003475 DNA repair protein RadA; Provisional; Region: PRK11823 758793003476 Walker A motif; other site 758793003477 ATP binding site [chemical binding]; other site 758793003478 Walker B motif; other site 758793003479 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 758793003480 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 758793003481 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793003482 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793003483 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 758793003484 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793003485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793003486 ABC transporter; Region: ABC_tran_2; pfam12848 758793003487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793003488 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 758793003489 catalytic residues [active] 758793003490 dimer interface [polypeptide binding]; other site 758793003491 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 758793003492 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 758793003493 putative active site [active] 758793003494 catalytic site [active] 758793003495 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 758793003496 putative active site [active] 758793003497 catalytic site [active] 758793003498 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 758793003499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793003500 S-adenosylmethionine binding site [chemical binding]; other site 758793003501 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 758793003502 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 758793003503 metal binding site [ion binding]; metal-binding site 758793003504 dimer interface [polypeptide binding]; other site 758793003505 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 758793003506 ArsC family; Region: ArsC; pfam03960 758793003507 putative catalytic residues [active] 758793003508 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 758793003509 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 758793003510 trimer interface [polypeptide binding]; other site 758793003511 active site 758793003512 substrate binding site [chemical binding]; other site 758793003513 CoA binding site [chemical binding]; other site 758793003514 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 758793003515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793003516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003517 homodimer interface [polypeptide binding]; other site 758793003518 catalytic residue [active] 758793003519 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 758793003520 EamA-like transporter family; Region: EamA; cl17759 758793003521 EamA-like transporter family; Region: EamA; pfam00892 758793003522 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 758793003523 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 758793003524 Walker A/P-loop; other site 758793003525 ATP binding site [chemical binding]; other site 758793003526 Q-loop/lid; other site 758793003527 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 758793003528 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 758793003529 Q-loop/lid; other site 758793003530 ABC transporter signature motif; other site 758793003531 Walker B; other site 758793003532 D-loop; other site 758793003533 H-loop/switch region; other site 758793003534 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 758793003535 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 758793003536 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 758793003537 nucleotide binding pocket [chemical binding]; other site 758793003538 K-X-D-G motif; other site 758793003539 catalytic site [active] 758793003540 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 758793003541 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 758793003542 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 758793003543 Dimer interface [polypeptide binding]; other site 758793003544 BRCT sequence motif; other site 758793003545 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 758793003546 active site 758793003547 catalytic residues [active] 758793003548 metal binding site [ion binding]; metal-binding site 758793003549 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 758793003550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793003551 RNA binding surface [nucleotide binding]; other site 758793003552 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 758793003553 active site 758793003554 PII uridylyl-transferase; Provisional; Region: PRK03059 758793003555 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 758793003556 metal binding triad; other site 758793003557 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 758793003558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758793003559 Zn2+ binding site [ion binding]; other site 758793003560 Mg2+ binding site [ion binding]; other site 758793003561 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 758793003562 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 758793003563 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 758793003564 active site 758793003565 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 758793003566 rRNA interaction site [nucleotide binding]; other site 758793003567 S8 interaction site; other site 758793003568 putative laminin-1 binding site; other site 758793003569 elongation factor Ts; Provisional; Region: tsf; PRK09377 758793003570 UBA/TS-N domain; Region: UBA; pfam00627 758793003571 Elongation factor TS; Region: EF_TS; pfam00889 758793003572 Elongation factor TS; Region: EF_TS; pfam00889 758793003573 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 758793003574 putative nucleotide binding site [chemical binding]; other site 758793003575 uridine monophosphate binding site [chemical binding]; other site 758793003576 homohexameric interface [polypeptide binding]; other site 758793003577 ribosome recycling factor; Reviewed; Region: frr; PRK00083 758793003578 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 758793003579 hinge region; other site 758793003580 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 758793003581 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 758793003582 catalytic residue [active] 758793003583 putative FPP diphosphate binding site; other site 758793003584 putative FPP binding hydrophobic cleft; other site 758793003585 dimer interface [polypeptide binding]; other site 758793003586 putative IPP diphosphate binding site; other site 758793003587 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 758793003588 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 758793003589 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 758793003590 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 758793003591 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 758793003592 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 758793003593 zinc metallopeptidase RseP; Provisional; Region: PRK10779 758793003594 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 758793003595 active site 758793003596 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 758793003597 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 758793003598 protein binding site [polypeptide binding]; other site 758793003599 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 758793003600 putative substrate binding region [chemical binding]; other site 758793003601 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 758793003602 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 758793003603 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 758793003604 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 758793003605 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 758793003606 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 758793003607 Surface antigen; Region: Bac_surface_Ag; pfam01103 758793003608 periplasmic chaperone; Provisional; Region: PRK10780 758793003609 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 758793003610 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 758793003611 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 758793003612 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 758793003613 trimer interface [polypeptide binding]; other site 758793003614 active site 758793003615 UDP-GlcNAc binding site [chemical binding]; other site 758793003616 lipid binding site [chemical binding]; lipid-binding site 758793003617 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 758793003618 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 758793003619 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 758793003620 active site 758793003621 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 758793003622 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 758793003623 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 758793003624 RNA/DNA hybrid binding site [nucleotide binding]; other site 758793003625 active site 758793003626 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 758793003627 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 758793003628 PEP synthetase regulatory protein; Provisional; Region: PRK05339 758793003629 phosphoenolpyruvate synthase; Validated; Region: PRK06464 758793003630 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 758793003631 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 758793003632 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 758793003633 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 758793003634 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 758793003635 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 758793003636 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 758793003637 SmpB-tmRNA interface; other site 758793003638 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 758793003639 putative coenzyme Q binding site [chemical binding]; other site 758793003640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 758793003641 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 758793003642 EamA-like transporter family; Region: EamA; pfam00892 758793003643 IMP dehydrogenase / GMP reductase domain; Region: IMPDH; pfam00478 758793003644 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 758793003645 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 758793003646 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 758793003647 active site 758793003648 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 758793003649 GMP synthase; Reviewed; Region: guaA; PRK00074 758793003650 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 758793003651 AMP/PPi binding site [chemical binding]; other site 758793003652 candidate oxyanion hole; other site 758793003653 catalytic triad [active] 758793003654 potential glutamine specificity residues [chemical binding]; other site 758793003655 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 758793003656 ATP Binding subdomain [chemical binding]; other site 758793003657 Ligand Binding sites [chemical binding]; other site 758793003658 Dimerization subdomain; other site 758793003659 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 758793003660 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 758793003661 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 758793003662 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793003663 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 758793003664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758793003665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793003666 dimer interface [polypeptide binding]; other site 758793003667 conserved gate region; other site 758793003668 putative PBP binding loops; other site 758793003669 ABC-ATPase subunit interface; other site 758793003670 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 758793003671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793003672 dimer interface [polypeptide binding]; other site 758793003673 conserved gate region; other site 758793003674 ABC-ATPase subunit interface; other site 758793003675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793003676 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 758793003677 Walker A/P-loop; other site 758793003678 ATP binding site [chemical binding]; other site 758793003679 Q-loop/lid; other site 758793003680 ABC transporter signature motif; other site 758793003681 Walker B; other site 758793003682 D-loop; other site 758793003683 H-loop/switch region; other site 758793003684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793003685 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 758793003686 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793003687 Walker A/P-loop; other site 758793003688 ATP binding site [chemical binding]; other site 758793003689 Q-loop/lid; other site 758793003690 ABC transporter signature motif; other site 758793003691 Walker B; other site 758793003692 D-loop; other site 758793003693 H-loop/switch region; other site 758793003694 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 758793003695 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 758793003696 nucleoside/Zn binding site; other site 758793003697 dimer interface [polypeptide binding]; other site 758793003698 catalytic motif [active] 758793003699 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 758793003700 dimer interface [polypeptide binding]; other site 758793003701 catalytic triad [active] 758793003702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793003703 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793003704 DNA-binding site [nucleotide binding]; DNA binding site 758793003705 FCD domain; Region: FCD; pfam07729 758793003706 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 758793003707 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 758793003708 Na binding site [ion binding]; other site 758793003709 putative substrate binding site [chemical binding]; other site 758793003710 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 758793003711 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 758793003712 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 758793003713 active site 758793003714 catalytic site [active] 758793003715 tetramer interface [polypeptide binding]; other site 758793003716 OHCU decarboxylase; Region: UHCUDC; TIGR03164 758793003717 allantoicase; Provisional; Region: PRK13257 758793003718 Allantoicase repeat; Region: Allantoicase; pfam03561 758793003719 Allantoicase repeat; Region: Allantoicase; pfam03561 758793003720 ureidoglycolate hydrolase; Provisional; Region: PRK03606 758793003721 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 758793003722 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 758793003723 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 758793003724 tetramer interface [polypeptide binding]; other site 758793003725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003726 catalytic residue [active] 758793003727 Predicted membrane protein [Function unknown]; Region: COG3748 758793003728 Protein of unknown function (DUF989); Region: DUF989; pfam06181 758793003729 Cytochrome c; Region: Cytochrom_C; pfam00034 758793003730 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 758793003731 active site 758793003732 homotetramer interface [polypeptide binding]; other site 758793003733 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 758793003734 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 758793003735 active site 758793003736 putative substrate binding pocket [chemical binding]; other site 758793003737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793003738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003739 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 758793003740 putative substrate binding pocket [chemical binding]; other site 758793003741 putative dimerization interface [polypeptide binding]; other site 758793003742 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 758793003743 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793003744 Walker A/P-loop; other site 758793003745 ATP binding site [chemical binding]; other site 758793003746 Q-loop/lid; other site 758793003747 ABC transporter signature motif; other site 758793003748 Walker B; other site 758793003749 D-loop; other site 758793003750 H-loop/switch region; other site 758793003751 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793003752 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793003753 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 758793003754 TM-ABC transporter signature motif; other site 758793003755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793003756 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 758793003757 TM-ABC transporter signature motif; other site 758793003758 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 758793003759 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 758793003760 putative ligand binding site [chemical binding]; other site 758793003761 Dodecin; Region: Dodecin; pfam07311 758793003762 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 758793003763 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 758793003764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 758793003765 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 758793003766 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 758793003767 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 758793003768 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 758793003769 active site 758793003770 catalytic site [active] 758793003771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793003772 TPR repeat; Region: TPR_11; pfam13414 758793003773 TPR motif; other site 758793003774 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 758793003775 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 758793003776 Transglycosylase; Region: Transgly; pfam00912 758793003777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 758793003778 Protein of unknown function (DUF461); Region: DUF461; pfam04314 758793003779 CopC domain; Region: CopC; pfam04234 758793003780 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 758793003781 hypothetical protein; Provisional; Region: PRK02487 758793003782 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 758793003783 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 758793003784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793003785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793003786 WHG domain; Region: WHG; pfam13305 758793003787 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 758793003788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793003789 substrate binding site [chemical binding]; other site 758793003790 oxyanion hole (OAH) forming residues; other site 758793003791 trimer interface [polypeptide binding]; other site 758793003792 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 758793003793 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 758793003794 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 758793003795 FMN binding site [chemical binding]; other site 758793003796 active site 758793003797 catalytic residues [active] 758793003798 substrate binding site [chemical binding]; other site 758793003799 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793003800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793003801 S-adenosylmethionine binding site [chemical binding]; other site 758793003802 short chain dehydrogenase; Provisional; Region: PRK06500 758793003803 classical (c) SDRs; Region: SDR_c; cd05233 758793003804 NAD(P) binding site [chemical binding]; other site 758793003805 active site 758793003806 Uncharacterized conserved protein [Function unknown]; Region: COG1359 758793003807 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 758793003808 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793003809 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793003810 catalytic residue [active] 758793003811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793003812 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793003813 putative substrate translocation pore; other site 758793003814 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793003815 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793003816 active site 758793003817 catalytic tetrad [active] 758793003818 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 758793003819 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 758793003820 TPP-binding site [chemical binding]; other site 758793003821 dimer interface [polypeptide binding]; other site 758793003822 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758793003823 PYR/PP interface [polypeptide binding]; other site 758793003824 dimer interface [polypeptide binding]; other site 758793003825 TPP binding site [chemical binding]; other site 758793003826 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793003827 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793003828 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 758793003829 ABC-2 type transporter; Region: ABC2_membrane; cl17235 758793003830 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758793003831 nodulation ABC transporter NodI; Provisional; Region: PRK13537 758793003832 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 758793003833 Walker A/P-loop; other site 758793003834 ATP binding site [chemical binding]; other site 758793003835 Q-loop/lid; other site 758793003836 ABC transporter signature motif; other site 758793003837 Walker B; other site 758793003838 D-loop; other site 758793003839 H-loop/switch region; other site 758793003840 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 758793003841 Ligand Binding Site [chemical binding]; other site 758793003842 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 758793003843 LexA repressor; Validated; Region: PRK00215 758793003844 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 758793003845 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 758793003846 Catalytic site [active] 758793003847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793003848 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 758793003849 substrate binding pocket [chemical binding]; other site 758793003850 membrane-bound complex binding site; other site 758793003851 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 758793003852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793003853 dimer interface [polypeptide binding]; other site 758793003854 conserved gate region; other site 758793003855 putative PBP binding loops; other site 758793003856 ABC-ATPase subunit interface; other site 758793003857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793003858 dimer interface [polypeptide binding]; other site 758793003859 conserved gate region; other site 758793003860 putative PBP binding loops; other site 758793003861 ABC-ATPase subunit interface; other site 758793003862 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 758793003863 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 758793003864 Walker A/P-loop; other site 758793003865 ATP binding site [chemical binding]; other site 758793003866 Q-loop/lid; other site 758793003867 ABC transporter signature motif; other site 758793003868 Walker B; other site 758793003869 D-loop; other site 758793003870 H-loop/switch region; other site 758793003871 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 758793003872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003873 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 758793003874 substrate binding site [chemical binding]; other site 758793003875 dimerization interface [polypeptide binding]; other site 758793003876 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 758793003877 active site 758793003878 homotetramer interface [polypeptide binding]; other site 758793003879 homodimer interface [polypeptide binding]; other site 758793003880 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 758793003881 BON domain; Region: BON; pfam04972 758793003882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758793003883 tartronate semialdehyde reductase; Provisional; Region: PRK15059 758793003884 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793003885 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 758793003886 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793003887 glyoxylate carboligase; Provisional; Region: PRK11269 758793003888 PYR/PP interface [polypeptide binding]; other site 758793003889 dimer interface [polypeptide binding]; other site 758793003890 TPP binding site [chemical binding]; other site 758793003891 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793003892 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 758793003893 TPP-binding site [chemical binding]; other site 758793003894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793003895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793003896 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793003897 putative effector binding pocket; other site 758793003898 dimerization interface [polypeptide binding]; other site 758793003899 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 758793003900 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 758793003901 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 758793003902 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 758793003903 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 758793003904 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 758793003905 replicative DNA helicase; Provisional; Region: PRK07004 758793003906 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 758793003907 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 758793003908 Walker A motif; other site 758793003909 ATP binding site [chemical binding]; other site 758793003910 Walker B motif; other site 758793003911 DNA binding loops [nucleotide binding] 758793003912 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 758793003913 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 758793003914 short chain dehydrogenase; Provisional; Region: PRK06125 758793003915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793003916 NAD(P) binding site [chemical binding]; other site 758793003917 active site 758793003918 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 758793003919 NlpC/P60 family; Region: NLPC_P60; pfam00877 758793003920 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 758793003921 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 758793003922 putative active site [active] 758793003923 PhoH-like protein; Region: PhoH; pfam02562 758793003924 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 758793003925 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 758793003926 catalytic triad [active] 758793003927 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 758793003928 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 758793003929 putative active site [active] 758793003930 putative catalytic site [active] 758793003931 putative Zn binding site [ion binding]; other site 758793003932 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 758793003933 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 758793003934 NAD binding site [chemical binding]; other site 758793003935 substrate binding site [chemical binding]; other site 758793003936 active site 758793003937 putative formyltransferase; Provisional; Region: PRK06988 758793003938 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 758793003939 active site 758793003940 substrate binding site [chemical binding]; other site 758793003941 cosubstrate binding site; other site 758793003942 catalytic site [active] 758793003943 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 758793003944 active site 758793003945 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 758793003946 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 758793003947 Ligand binding site; other site 758793003948 Putative Catalytic site; other site 758793003949 DXD motif; other site 758793003950 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 758793003951 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 758793003952 inhibitor-cofactor binding pocket; inhibition site 758793003953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003954 catalytic residue [active] 758793003955 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 758793003956 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 758793003957 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 758793003958 aminotransferase AlaT; Validated; Region: PRK09265 758793003959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793003960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003961 homodimer interface [polypeptide binding]; other site 758793003962 catalytic residue [active] 758793003963 homoserine dehydrogenase; Provisional; Region: PRK06349 758793003964 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 758793003965 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 758793003966 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 758793003967 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 758793003968 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 758793003969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793003970 catalytic residue [active] 758793003971 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 758793003972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793003973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793003974 ABC transporter; Region: ABC_tran_2; pfam12848 758793003975 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793003976 Predicted Fe-S protein [General function prediction only]; Region: COG3313 758793003977 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 758793003978 substrate binding site [chemical binding]; other site 758793003979 dimerization interface [polypeptide binding]; other site 758793003980 active site 758793003981 calcium binding site [ion binding]; other site 758793003982 manganese transport protein MntH; Reviewed; Region: PRK00701 758793003983 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 758793003984 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 758793003985 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758793003986 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 758793003987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793003988 Walker A/P-loop; other site 758793003989 ATP binding site [chemical binding]; other site 758793003990 Q-loop/lid; other site 758793003991 ABC transporter signature motif; other site 758793003992 Walker B; other site 758793003993 D-loop; other site 758793003994 H-loop/switch region; other site 758793003995 TOBE domain; Region: TOBE_2; pfam08402 758793003996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793003997 dimer interface [polypeptide binding]; other site 758793003998 conserved gate region; other site 758793003999 putative PBP binding loops; other site 758793004000 ABC-ATPase subunit interface; other site 758793004001 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793004002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793004003 dimer interface [polypeptide binding]; other site 758793004004 conserved gate region; other site 758793004005 putative PBP binding loops; other site 758793004006 ABC-ATPase subunit interface; other site 758793004007 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 758793004008 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 758793004009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793004010 catalytic residue [active] 758793004011 acetylornithine deacetylase; Provisional; Region: PRK07522 758793004012 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 758793004013 metal binding site [ion binding]; metal-binding site 758793004014 putative dimer interface [polypeptide binding]; other site 758793004015 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 758793004016 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 758793004017 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793004018 ATP binding site [chemical binding]; other site 758793004019 putative Mg++ binding site [ion binding]; other site 758793004020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793004021 nucleotide binding region [chemical binding]; other site 758793004022 ATP-binding site [chemical binding]; other site 758793004023 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 758793004024 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 758793004025 substrate binding site; other site 758793004026 dimer interface; other site 758793004027 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 758793004028 homotrimer interaction site [polypeptide binding]; other site 758793004029 zinc binding site [ion binding]; other site 758793004030 CDP-binding sites; other site 758793004031 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 758793004032 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 758793004033 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 758793004034 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 758793004035 dimer interface [polypeptide binding]; other site 758793004036 decamer (pentamer of dimers) interface [polypeptide binding]; other site 758793004037 catalytic triad [active] 758793004038 peroxidatic and resolving cysteines [active] 758793004039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 758793004040 dimerization interface [polypeptide binding]; other site 758793004041 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793004042 dimer interface [polypeptide binding]; other site 758793004043 phosphorylation site [posttranslational modification] 758793004044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793004045 ATP binding site [chemical binding]; other site 758793004046 Mg2+ binding site [ion binding]; other site 758793004047 G-X-G motif; other site 758793004048 osmolarity response regulator; Provisional; Region: ompR; PRK09468 758793004049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793004050 active site 758793004051 phosphorylation site [posttranslational modification] 758793004052 intermolecular recognition site; other site 758793004053 dimerization interface [polypeptide binding]; other site 758793004054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793004055 DNA binding site [nucleotide binding] 758793004056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 758793004057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 758793004058 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 758793004059 substrate binding pocket [chemical binding]; other site 758793004060 substrate-Mg2+ binding site; other site 758793004061 aspartate-rich region 1; other site 758793004062 aspartate-rich region 2; other site 758793004063 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 758793004064 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 758793004065 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 758793004066 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 758793004067 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 758793004068 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 758793004069 trigger factor; Provisional; Region: tig; PRK01490 758793004070 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 758793004071 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 758793004072 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 758793004073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 758793004074 oligomer interface [polypeptide binding]; other site 758793004075 active site residues [active] 758793004076 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 758793004077 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 758793004078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793004079 Walker A motif; other site 758793004080 ATP binding site [chemical binding]; other site 758793004081 Walker B motif; other site 758793004082 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 758793004083 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 758793004084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793004085 Walker A motif; other site 758793004086 ATP binding site [chemical binding]; other site 758793004087 Walker B motif; other site 758793004088 arginine finger; other site 758793004089 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 758793004090 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 758793004091 IHF dimer interface [polypeptide binding]; other site 758793004092 IHF - DNA interface [nucleotide binding]; other site 758793004093 SurA N-terminal domain; Region: SurA_N_3; cl07813 758793004094 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 758793004095 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 758793004096 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 758793004097 active site 758793004098 catalytic triad [active] 758793004099 oxyanion hole [active] 758793004100 switch loop; other site 758793004101 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 758793004102 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758793004103 Walker A/P-loop; other site 758793004104 ATP binding site [chemical binding]; other site 758793004105 Q-loop/lid; other site 758793004106 ABC transporter signature motif; other site 758793004107 Walker B; other site 758793004108 D-loop; other site 758793004109 H-loop/switch region; other site 758793004110 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 758793004111 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 758793004112 active site 758793004113 dimer interface [polypeptide binding]; other site 758793004114 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 758793004115 dimer interface [polypeptide binding]; other site 758793004116 active site 758793004117 Uncharacterized conserved protein [Function unknown]; Region: COG0062 758793004118 putative carbohydrate kinase; Provisional; Region: PRK10565 758793004119 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 758793004120 putative substrate binding site [chemical binding]; other site 758793004121 putative ATP binding site [chemical binding]; other site 758793004122 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 758793004123 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 758793004124 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 758793004125 dimerization interface [polypeptide binding]; other site 758793004126 ATP binding site [chemical binding]; other site 758793004127 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 758793004128 dimerization interface [polypeptide binding]; other site 758793004129 ATP binding site [chemical binding]; other site 758793004130 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 758793004131 putative active site [active] 758793004132 catalytic triad [active] 758793004133 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 758793004134 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 758793004135 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 758793004136 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 758793004137 active site 758793004138 SurA N-terminal domain; Region: SurA_N_3; cl07813 758793004139 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 758793004140 BolA-like protein; Region: BolA; pfam01722 758793004141 intracellular septation protein A; Reviewed; Region: PRK00259 758793004142 methionine sulfoxide reductase B; Provisional; Region: PRK00222 758793004143 SelR domain; Region: SelR; pfam01641 758793004144 Uncharacterized conserved protein [Function unknown]; Region: COG0397 758793004145 hypothetical protein; Validated; Region: PRK00029 758793004146 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 758793004147 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 758793004148 dimer interface [polypeptide binding]; other site 758793004149 acyl-activating enzyme (AAE) consensus motif; other site 758793004150 putative active site [active] 758793004151 AMP binding site [chemical binding]; other site 758793004152 putative CoA binding site [chemical binding]; other site 758793004153 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 758793004154 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793004155 substrate binding site [chemical binding]; other site 758793004156 oxyanion hole (OAH) forming residues; other site 758793004157 trimer interface [polypeptide binding]; other site 758793004158 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793004159 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793004160 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793004161 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 758793004162 Isochorismatase family; Region: Isochorismatase; pfam00857 758793004163 catalytic triad [active] 758793004164 metal binding site [ion binding]; metal-binding site 758793004165 conserved cis-peptide bond; other site 758793004166 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 758793004167 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793004168 dimer interface [polypeptide binding]; other site 758793004169 active site 758793004170 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 758793004171 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 758793004172 CoenzymeA binding site [chemical binding]; other site 758793004173 subunit interaction site [polypeptide binding]; other site 758793004174 PHB binding site; other site 758793004175 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 758793004176 Prostaglandin dehydrogenases; Region: PGDH; cd05288 758793004177 NAD(P) binding site [chemical binding]; other site 758793004178 substrate binding site [chemical binding]; other site 758793004179 dimer interface [polypeptide binding]; other site 758793004180 hypothetical protein; Provisional; Region: PRK06194 758793004181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793004182 NAD(P) binding site [chemical binding]; other site 758793004183 active site 758793004184 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 758793004185 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793004186 substrate binding pocket [chemical binding]; other site 758793004187 NRDE protein; Region: NRDE; cl01315 758793004188 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 758793004189 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 758793004190 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 758793004191 YceG-like family; Region: YceG; pfam02618 758793004192 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 758793004193 dimerization interface [polypeptide binding]; other site 758793004194 thymidylate kinase; Validated; Region: tmk; PRK00698 758793004195 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 758793004196 TMP-binding site; other site 758793004197 ATP-binding site [chemical binding]; other site 758793004198 DNA polymerase III subunit delta'; Validated; Region: PRK06964 758793004199 DNA polymerase III subunit delta'; Validated; Region: PRK08485 758793004200 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 758793004201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793004202 Coenzyme A binding pocket [chemical binding]; other site 758793004203 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 758793004204 active site 758793004205 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 758793004206 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 758793004207 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 758793004208 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793004209 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793004210 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 758793004211 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 758793004212 active site 758793004213 homotetramer interface [polypeptide binding]; other site 758793004214 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 758793004215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793004216 putative ADP-binding pocket [chemical binding]; other site 758793004217 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 758793004218 hypothetical protein; Provisional; Region: PRK11505 758793004219 psiF repeat; Region: PsiF_repeat; pfam07769 758793004220 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 758793004221 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793004222 ligand binding site [chemical binding]; other site 758793004223 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793004224 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793004225 Walker A/P-loop; other site 758793004226 ATP binding site [chemical binding]; other site 758793004227 Q-loop/lid; other site 758793004228 ABC transporter signature motif; other site 758793004229 Walker B; other site 758793004230 D-loop; other site 758793004231 H-loop/switch region; other site 758793004232 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793004233 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793004234 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793004235 TM-ABC transporter signature motif; other site 758793004236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793004237 DNA binding site [nucleotide binding] 758793004238 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 758793004239 domain linker motif; other site 758793004240 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 758793004241 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793004242 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 758793004243 substrate binding site [chemical binding]; other site 758793004244 dimer interface [polypeptide binding]; other site 758793004245 ATP binding site [chemical binding]; other site 758793004246 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758793004247 Tar ligand binding domain homologue; Region: TarH; pfam02203 758793004248 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793004249 dimerization interface [polypeptide binding]; other site 758793004250 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758793004251 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793004252 dimer interface [polypeptide binding]; other site 758793004253 putative CheW interface [polypeptide binding]; other site 758793004254 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 758793004255 PrkA family serine protein kinase; Provisional; Region: PRK15455 758793004256 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 758793004257 hypothetical protein; Provisional; Region: PRK05325 758793004258 SpoVR family protein; Provisional; Region: PRK11767 758793004259 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 758793004260 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 758793004261 Predicted permeases [General function prediction only]; Region: RarD; COG2962 758793004262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793004263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793004264 active site 758793004265 catalytic tetrad [active] 758793004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793004267 putative transporter; Provisional; Region: PRK10504 758793004268 putative substrate translocation pore; other site 758793004269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793004270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793004271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793004272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793004273 dimerization interface [polypeptide binding]; other site 758793004274 Tannase and feruloyl esterase; Region: Tannase; pfam07519 758793004275 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 758793004276 YCII-related domain; Region: YCII; cl00999 758793004277 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 758793004278 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793004279 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 758793004280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793004281 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 758793004282 DNA binding residues [nucleotide binding] 758793004283 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 758793004284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793004285 S-adenosylmethionine binding site [chemical binding]; other site 758793004286 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 758793004287 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 758793004288 tyrosine kinase; Provisional; Region: PRK11519 758793004289 Chain length determinant protein; Region: Wzz; cl15801 758793004290 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 758793004291 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793004292 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793004293 Magnesium ion binding site [ion binding]; other site 758793004294 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 758793004295 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 758793004296 FOG: CBS domain [General function prediction only]; Region: COG0517 758793004297 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 758793004298 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 758793004299 active site clefts [active] 758793004300 zinc binding site [ion binding]; other site 758793004301 dimer interface [polypeptide binding]; other site 758793004302 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 758793004303 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 758793004304 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 758793004305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 758793004306 active site 758793004307 phosphorylation site [posttranslational modification] 758793004308 intermolecular recognition site; other site 758793004309 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 758793004310 EamA-like transporter family; Region: EamA; pfam00892 758793004311 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758793004312 EamA-like transporter family; Region: EamA; pfam00892 758793004313 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 758793004314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793004315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793004316 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793004317 putative effector binding pocket; other site 758793004318 dimerization interface [polypeptide binding]; other site 758793004319 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 758793004320 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 758793004321 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 758793004322 FecR protein; Region: FecR; pfam04773 758793004323 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 758793004324 Sulfate transporter family; Region: Sulfate_transp; pfam00916 758793004325 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 758793004326 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793004327 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793004328 ligand binding site [chemical binding]; other site 758793004329 flexible hinge region; other site 758793004330 CHASE2 domain; Region: CHASE2; pfam05226 758793004331 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 758793004332 cyclase homology domain; Region: CHD; cd07302 758793004333 nucleotidyl binding site; other site 758793004334 metal binding site [ion binding]; metal-binding site 758793004335 dimer interface [polypeptide binding]; other site 758793004336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 758793004337 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 758793004338 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 758793004339 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 758793004340 gating phenylalanine in ion channel; other site 758793004341 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 758793004342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793004343 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 758793004344 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 758793004345 Na binding site [ion binding]; other site 758793004346 putative substrate binding site [chemical binding]; other site 758793004347 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 758793004348 EamA-like transporter family; Region: EamA; pfam00892 758793004349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793004350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793004351 metal binding site [ion binding]; metal-binding site 758793004352 active site 758793004353 I-site; other site 758793004354 recombination associated protein; Reviewed; Region: rdgC; PRK00321 758793004355 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 758793004356 EamA-like transporter family; Region: EamA; pfam00892 758793004357 EamA-like transporter family; Region: EamA; pfam00892 758793004358 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793004359 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 758793004360 dimerization interface [polypeptide binding]; other site 758793004361 putative DNA binding site [nucleotide binding]; other site 758793004362 putative Zn2+ binding site [ion binding]; other site 758793004363 AsnC family; Region: AsnC_trans_reg; pfam01037 758793004364 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 758793004365 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793004366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793004367 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793004368 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793004369 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793004370 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793004371 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 758793004372 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 758793004373 active site 758793004374 AMP binding site [chemical binding]; other site 758793004375 homodimer interface [polypeptide binding]; other site 758793004376 acyl-activating enzyme (AAE) consensus motif; other site 758793004377 CoA binding site [chemical binding]; other site 758793004378 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 758793004379 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793004380 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793004381 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793004382 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 758793004383 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793004384 dimer interface [polypeptide binding]; other site 758793004385 active site 758793004386 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 758793004387 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 758793004388 FAD binding pocket [chemical binding]; other site 758793004389 FAD binding motif [chemical binding]; other site 758793004390 phosphate binding motif [ion binding]; other site 758793004391 beta-alpha-beta structure motif; other site 758793004392 NAD(p) ribose binding residues [chemical binding]; other site 758793004393 NAD binding pocket [chemical binding]; other site 758793004394 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 758793004395 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793004396 catalytic loop [active] 758793004397 iron binding site [ion binding]; other site 758793004398 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 758793004399 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 758793004400 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 758793004401 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 758793004402 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 758793004403 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 758793004404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 758793004405 Transposase, Mutator family; Region: Transposase_mut; pfam00872 758793004406 Transposase, Mutator family; Region: Transposase_mut; pfam00872 758793004407 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 758793004408 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 758793004409 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793004410 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793004411 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 758793004412 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793004413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793004414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793004415 NAD(P) binding site [chemical binding]; other site 758793004416 active site 758793004417 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793004418 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793004419 trimer interface [polypeptide binding]; other site 758793004420 eyelet of channel; other site 758793004421 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793004422 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 758793004423 [2Fe-2S] cluster binding site [ion binding]; other site 758793004424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793004425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793004426 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793004427 putative effector binding pocket; other site 758793004428 dimerization interface [polypeptide binding]; other site 758793004429 EamA-like transporter family; Region: EamA; pfam00892 758793004430 Protein of unknown function (DUF938); Region: DUF938; pfam06080 758793004431 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 758793004432 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 758793004433 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 758793004434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793004435 mercuric reductase; Validated; Region: PRK06370 758793004436 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793004437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793004438 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793004439 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 758793004440 AAA domain; Region: AAA_33; pfam13671 758793004441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758793004442 Walker A motif; other site 758793004443 ATP binding site [chemical binding]; other site 758793004444 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 758793004445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793004446 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793004447 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 758793004448 AsnC family; Region: AsnC_trans_reg; pfam01037 758793004449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793004450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793004451 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 758793004452 putative effector binding pocket; other site 758793004453 putative dimerization interface [polypeptide binding]; other site 758793004454 LTXXQ motif family protein; Region: LTXXQ; pfam07813 758793004455 PGDYG protein; Region: PGDYG; pfam14083 758793004456 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 758793004457 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 758793004458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793004459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793004460 DNA binding site [nucleotide binding] 758793004461 domain linker motif; other site 758793004462 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 758793004463 putative dimerization interface [polypeptide binding]; other site 758793004464 putative ligand binding site [chemical binding]; other site 758793004465 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 758793004466 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 758793004467 dimerization interface [polypeptide binding]; other site 758793004468 ligand binding site [chemical binding]; other site 758793004469 NADP binding site [chemical binding]; other site 758793004470 catalytic site [active] 758793004471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793004472 D-galactonate transporter; Region: 2A0114; TIGR00893 758793004473 putative substrate translocation pore; other site 758793004474 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793004475 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 758793004476 substrate binding site [chemical binding]; other site 758793004477 ATP binding site [chemical binding]; other site 758793004478 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 758793004479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793004480 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 758793004481 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 758793004482 putative dimerization interface [polypeptide binding]; other site 758793004483 Predicted membrane protein [Function unknown]; Region: COG2855 758793004484 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 758793004485 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 758793004486 molybdopterin cofactor binding site; other site 758793004487 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 758793004488 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 758793004489 putative molybdopterin cofactor binding site; other site 758793004490 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 758793004491 4Fe-4S binding domain; Region: Fer4; pfam00037 758793004492 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 758793004493 hypothetical protein; Provisional; Region: PRK05939 758793004494 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758793004495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793004496 catalytic residue [active] 758793004497 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 758793004498 glutathione s-transferase; Provisional; Region: PTZ00057 758793004499 GSH binding site (G-site) [chemical binding]; other site 758793004500 C-terminal domain interface [polypeptide binding]; other site 758793004501 dimer interface [polypeptide binding]; other site 758793004502 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 758793004503 dimer interface [polypeptide binding]; other site 758793004504 N-terminal domain interface [polypeptide binding]; other site 758793004505 substrate binding pocket (H-site) [chemical binding]; other site 758793004506 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793004507 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793004508 active site 758793004509 catalytic tetrad [active] 758793004510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793004511 binding surface 758793004512 TPR motif; other site 758793004513 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 758793004514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793004515 binding surface 758793004516 TPR motif; other site 758793004517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793004518 TPR motif; other site 758793004519 binding surface 758793004520 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793004521 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 758793004522 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 758793004523 Cl- selectivity filter; other site 758793004524 Cl- binding residues [ion binding]; other site 758793004525 pore gating glutamate residue; other site 758793004526 dimer interface [polypeptide binding]; other site 758793004527 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 758793004528 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 758793004529 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 758793004530 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 758793004531 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793004532 N-terminal plug; other site 758793004533 ligand-binding site [chemical binding]; other site 758793004534 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 758793004535 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 758793004536 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 758793004537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793004538 Walker A/P-loop; other site 758793004539 ATP binding site [chemical binding]; other site 758793004540 Q-loop/lid; other site 758793004541 ABC transporter signature motif; other site 758793004542 Walker B; other site 758793004543 D-loop; other site 758793004544 H-loop/switch region; other site 758793004545 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 758793004546 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 758793004547 dimer interface [polypeptide binding]; other site 758793004548 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 758793004549 putative dimer interface [polypeptide binding]; other site 758793004550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793004551 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793004552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793004553 active site 758793004554 phosphorylation site [posttranslational modification] 758793004555 intermolecular recognition site; other site 758793004556 dimerization interface [polypeptide binding]; other site 758793004557 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 758793004558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793004559 putative active site [active] 758793004560 heme pocket [chemical binding]; other site 758793004561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793004562 dimer interface [polypeptide binding]; other site 758793004563 phosphorylation site [posttranslational modification] 758793004564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793004565 ATP binding site [chemical binding]; other site 758793004566 Mg2+ binding site [ion binding]; other site 758793004567 G-X-G motif; other site 758793004568 Response regulator receiver domain; Region: Response_reg; pfam00072 758793004569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793004570 active site 758793004571 phosphorylation site [posttranslational modification] 758793004572 intermolecular recognition site; other site 758793004573 dimerization interface [polypeptide binding]; other site 758793004574 Response regulator receiver domain; Region: Response_reg; pfam00072 758793004575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793004576 active site 758793004577 phosphorylation site [posttranslational modification] 758793004578 intermolecular recognition site; other site 758793004579 dimerization interface [polypeptide binding]; other site 758793004580 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 758793004581 GAF domain; Region: GAF; pfam01590 758793004582 Phytochrome region; Region: PHY; pfam00360 758793004583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793004584 dimer interface [polypeptide binding]; other site 758793004585 phosphorylation site [posttranslational modification] 758793004586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793004587 ATP binding site [chemical binding]; other site 758793004588 Mg2+ binding site [ion binding]; other site 758793004589 G-X-G motif; other site 758793004590 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 758793004591 heme binding pocket [chemical binding]; other site 758793004592 heme ligand [chemical binding]; other site 758793004593 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 758793004594 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 758793004595 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 758793004596 active site 758793004597 DNA binding site [nucleotide binding] 758793004598 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 758793004599 DNA binding site [nucleotide binding] 758793004600 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 758793004601 nucleotide binding site [chemical binding]; other site 758793004602 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 758793004603 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 758793004604 putative DNA binding site [nucleotide binding]; other site 758793004605 putative homodimer interface [polypeptide binding]; other site 758793004606 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 758793004607 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 758793004608 putative NAD(P) binding site [chemical binding]; other site 758793004609 dimer interface [polypeptide binding]; other site 758793004610 LysR family transcriptional regulator; Provisional; Region: PRK14997 758793004611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793004612 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793004613 putative effector binding pocket; other site 758793004614 dimerization interface [polypeptide binding]; other site 758793004615 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 758793004616 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 758793004617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793004618 motif II; other site 758793004619 cystathionine beta-lyase; Provisional; Region: PRK07050 758793004620 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758793004621 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793004622 catalytic residue [active] 758793004623 beta-ketothiolase; Provisional; Region: PRK09051 758793004624 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793004625 dimer interface [polypeptide binding]; other site 758793004626 active site 758793004627 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793004628 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 758793004629 substrate binding site [chemical binding]; other site 758793004630 ATP binding site [chemical binding]; other site 758793004631 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 758793004632 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 758793004633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793004634 FeS/SAM binding site; other site 758793004635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 758793004636 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 758793004637 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 758793004638 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 758793004639 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 758793004640 NAD(P) binding site [chemical binding]; other site 758793004641 homotetramer interface [polypeptide binding]; other site 758793004642 homodimer interface [polypeptide binding]; other site 758793004643 active site 758793004644 putative acyltransferase; Provisional; Region: PRK05790 758793004645 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793004646 dimer interface [polypeptide binding]; other site 758793004647 active site 758793004648 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 758793004649 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 758793004650 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 758793004651 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 758793004652 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 758793004653 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793004654 RNA binding surface [nucleotide binding]; other site 758793004655 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 758793004656 active site 758793004657 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 758793004658 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 758793004659 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 758793004660 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 758793004661 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 758793004662 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 758793004663 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 758793004664 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 758793004665 RNA binding site [nucleotide binding]; other site 758793004666 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 758793004667 potassium uptake protein; Region: kup; TIGR00794 758793004668 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 758793004669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793004670 active site 758793004671 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 758793004672 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 758793004673 GDP-binding site [chemical binding]; other site 758793004674 ACT binding site; other site 758793004675 IMP binding site; other site 758793004676 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 758793004677 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 758793004678 dimer interface [polypeptide binding]; other site 758793004679 motif 1; other site 758793004680 active site 758793004681 motif 2; other site 758793004682 motif 3; other site 758793004683 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 758793004684 FtsH protease regulator HflC; Provisional; Region: PRK11029 758793004685 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 758793004686 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 758793004687 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 758793004688 HflK protein; Region: hflK; TIGR01933 758793004689 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 758793004690 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 758793004691 HflX GTPase family; Region: HflX; cd01878 758793004692 G1 box; other site 758793004693 GTP/Mg2+ binding site [chemical binding]; other site 758793004694 Switch I region; other site 758793004695 G2 box; other site 758793004696 G3 box; other site 758793004697 Switch II region; other site 758793004698 G4 box; other site 758793004699 G5 box; other site 758793004700 bacterial Hfq-like; Region: Hfq; cd01716 758793004701 hexamer interface [polypeptide binding]; other site 758793004702 Sm1 motif; other site 758793004703 RNA binding site [nucleotide binding]; other site 758793004704 Sm2 motif; other site 758793004705 GTP-binding protein Der; Reviewed; Region: PRK00093 758793004706 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 758793004707 GTP/Mg2+ binding site [chemical binding]; other site 758793004708 Switch I region; other site 758793004709 G2 box; other site 758793004710 Switch II region; other site 758793004711 G3 box; other site 758793004712 G4 box; other site 758793004713 G5 box; other site 758793004714 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 758793004715 G1 box; other site 758793004716 GTP/Mg2+ binding site [chemical binding]; other site 758793004717 Switch I region; other site 758793004718 G2 box; other site 758793004719 G3 box; other site 758793004720 Switch II region; other site 758793004721 G4 box; other site 758793004722 G5 box; other site 758793004723 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 758793004724 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 758793004725 Trp docking motif [polypeptide binding]; other site 758793004726 active site 758793004727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 758793004728 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 758793004729 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 758793004730 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 758793004731 dimer interface [polypeptide binding]; other site 758793004732 motif 1; other site 758793004733 active site 758793004734 motif 2; other site 758793004735 motif 3; other site 758793004736 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 758793004737 anticodon binding site; other site 758793004738 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 758793004739 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 758793004740 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 758793004741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758793004742 non-specific DNA binding site [nucleotide binding]; other site 758793004743 salt bridge; other site 758793004744 sequence-specific DNA binding site [nucleotide binding]; other site 758793004745 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 758793004746 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 758793004747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793004748 FeS/SAM binding site; other site 758793004749 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 758793004750 active site 758793004751 multimer interface [polypeptide binding]; other site 758793004752 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 758793004753 YccA-like proteins; Region: YccA_like; cd10433 758793004754 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 758793004755 TRAM domain; Region: TRAM; cl01282 758793004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793004757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793004758 S-adenosylmethionine binding site [chemical binding]; other site 758793004759 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 758793004760 active site 758793004761 catalytic site [active] 758793004762 substrate binding site [chemical binding]; other site 758793004763 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 758793004764 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 758793004765 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 758793004766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793004767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793004768 DNA binding residues [nucleotide binding] 758793004769 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 758793004770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758793004771 Peptidase family M23; Region: Peptidase_M23; pfam01551 758793004772 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 758793004773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793004774 S-adenosylmethionine binding site [chemical binding]; other site 758793004775 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 758793004776 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 758793004777 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 758793004778 NAD(P) binding site [chemical binding]; other site 758793004779 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793004780 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793004781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793004782 dimer interface [polypeptide binding]; other site 758793004783 conserved gate region; other site 758793004784 putative PBP binding loops; other site 758793004785 ABC-ATPase subunit interface; other site 758793004786 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793004787 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793004788 Walker A/P-loop; other site 758793004789 ATP binding site [chemical binding]; other site 758793004790 Q-loop/lid; other site 758793004791 ABC transporter signature motif; other site 758793004792 Walker B; other site 758793004793 D-loop; other site 758793004794 H-loop/switch region; other site 758793004795 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793004796 NMT1-like family; Region: NMT1_2; pfam13379 758793004797 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793004798 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793004799 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 758793004800 recombination protein RecR; Reviewed; Region: recR; PRK00076 758793004801 RecR protein; Region: RecR; pfam02132 758793004802 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 758793004803 putative active site [active] 758793004804 putative metal-binding site [ion binding]; other site 758793004805 tetramer interface [polypeptide binding]; other site 758793004806 hypothetical protein; Validated; Region: PRK00153 758793004807 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 758793004808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793004809 Walker A motif; other site 758793004810 ATP binding site [chemical binding]; other site 758793004811 Walker B motif; other site 758793004812 DNA polymerase III subunit delta'; Validated; Region: PRK08485 758793004813 arginine finger; other site 758793004814 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 758793004815 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758793004816 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793004817 catalytic residues [active] 758793004818 transcription termination factor Rho; Provisional; Region: rho; PRK09376 758793004819 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 758793004820 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 758793004821 RNA binding site [nucleotide binding]; other site 758793004822 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 758793004823 multimer interface [polypeptide binding]; other site 758793004824 Walker A motif; other site 758793004825 ATP binding site [chemical binding]; other site 758793004826 Walker B motif; other site 758793004827 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 758793004828 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 758793004829 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 758793004830 multidrug efflux protein; Reviewed; Region: PRK01766 758793004831 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 758793004832 cation binding site [ion binding]; other site 758793004833 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 758793004834 MG2 domain; Region: A2M_N; pfam01835 758793004835 Alpha-2-macroglobulin family; Region: A2M; pfam00207 758793004836 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 758793004837 Transglycosylase; Region: Transgly; pfam00912 758793004838 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 758793004839 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 758793004840 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 758793004841 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 758793004842 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 758793004843 Clp amino terminal domain; Region: Clp_N; pfam02861 758793004844 Clp amino terminal domain; Region: Clp_N; pfam02861 758793004845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793004846 Walker A motif; other site 758793004847 ATP binding site [chemical binding]; other site 758793004848 Walker B motif; other site 758793004849 arginine finger; other site 758793004850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793004851 Walker A motif; other site 758793004852 ATP binding site [chemical binding]; other site 758793004853 Walker B motif; other site 758793004854 arginine finger; other site 758793004855 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 758793004856 Transcriptional regulator; Region: Rrf2; cl17282 758793004857 Rrf2 family protein; Region: rrf2_super; TIGR00738 758793004858 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 758793004859 apolar tunnel; other site 758793004860 heme binding site [chemical binding]; other site 758793004861 dimerization interface [polypeptide binding]; other site 758793004862 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 758793004863 MoaE homodimer interface [polypeptide binding]; other site 758793004864 MoaD interaction [polypeptide binding]; other site 758793004865 active site residues [active] 758793004866 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 758793004867 MoaE interaction surface [polypeptide binding]; other site 758793004868 MoeB interaction surface [polypeptide binding]; other site 758793004869 thiocarboxylated glycine; other site 758793004870 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 758793004871 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 758793004872 dimer interface [polypeptide binding]; other site 758793004873 putative functional site; other site 758793004874 putative MPT binding site; other site 758793004875 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 758793004876 nudix motif; other site 758793004877 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 758793004878 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 758793004879 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 758793004880 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 758793004881 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 758793004882 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 758793004883 quinone interaction residues [chemical binding]; other site 758793004884 active site 758793004885 catalytic residues [active] 758793004886 FMN binding site [chemical binding]; other site 758793004887 substrate binding site [chemical binding]; other site 758793004888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793004889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793004890 substrate binding pocket [chemical binding]; other site 758793004891 membrane-bound complex binding site; other site 758793004892 hinge residues; other site 758793004893 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793004894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793004895 dimer interface [polypeptide binding]; other site 758793004896 conserved gate region; other site 758793004897 putative PBP binding loops; other site 758793004898 ABC-ATPase subunit interface; other site 758793004899 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793004900 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793004901 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793004902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793004903 DNA-binding site [nucleotide binding]; DNA binding site 758793004904 FCD domain; Region: FCD; pfam07729 758793004905 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793004906 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793004907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758793004908 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 758793004909 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793004910 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 758793004911 ligand binding site [chemical binding]; other site 758793004912 flexible hinge region; other site 758793004913 putative switch regulator; other site 758793004914 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 758793004915 non-specific DNA interactions [nucleotide binding]; other site 758793004916 DNA binding site [nucleotide binding] 758793004917 sequence specific DNA binding site [nucleotide binding]; other site 758793004918 putative cAMP binding site [chemical binding]; other site 758793004919 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 758793004920 Bacterial sugar transferase; Region: Bac_transf; pfam02397 758793004921 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 758793004922 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758793004923 active site 758793004924 dimer interface [polypeptide binding]; other site 758793004925 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 758793004926 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 758793004927 PapC N-terminal domain; Region: PapC_N; pfam13954 758793004928 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 758793004929 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 758793004930 PapC C-terminal domain; Region: PapC_C; pfam13953 758793004931 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 758793004932 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 758793004933 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 758793004934 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 758793004935 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 758793004936 amidase catalytic site [active] 758793004937 Zn binding residues [ion binding]; other site 758793004938 substrate binding site [chemical binding]; other site 758793004939 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 758793004940 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 758793004941 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 758793004942 ribonuclease R; Region: RNase_R; TIGR02063 758793004943 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 758793004944 RNB domain; Region: RNB; pfam00773 758793004945 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 758793004946 RNA binding site [nucleotide binding]; other site 758793004947 putative sialic acid transporter; Region: 2A0112; TIGR00891 758793004948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793004949 putative substrate translocation pore; other site 758793004950 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 758793004951 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793004952 active site 758793004953 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 758793004954 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 758793004955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793004956 active site 758793004957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793004958 NAD(P) binding site [chemical binding]; other site 758793004959 active site 758793004960 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 758793004961 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 758793004962 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 758793004963 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793004964 dimer interface [polypeptide binding]; other site 758793004965 active site 758793004966 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 758793004967 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793004968 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 758793004969 acyl-activating enzyme (AAE) consensus motif; other site 758793004970 putative AMP binding site [chemical binding]; other site 758793004971 putative active site [active] 758793004972 putative CoA binding site [chemical binding]; other site 758793004973 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 758793004974 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 758793004975 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 758793004976 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 758793004977 Predicted ATPase [General function prediction only]; Region: COG1485 758793004978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793004979 Walker B; other site 758793004980 D-loop; other site 758793004981 H-loop/switch region; other site 758793004982 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 758793004983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793004984 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793004985 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 758793004986 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793004987 E3 interaction surface; other site 758793004988 lipoyl attachment site [posttranslational modification]; other site 758793004989 e3 binding domain; Region: E3_binding; pfam02817 758793004990 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 758793004991 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 758793004992 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 758793004993 TPP-binding site [chemical binding]; other site 758793004994 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 758793004995 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 758793004996 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 758793004997 G1 box; other site 758793004998 putative GEF interaction site [polypeptide binding]; other site 758793004999 GTP/Mg2+ binding site [chemical binding]; other site 758793005000 Switch I region; other site 758793005001 G2 box; other site 758793005002 G3 box; other site 758793005003 Switch II region; other site 758793005004 G4 box; other site 758793005005 G5 box; other site 758793005006 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 758793005007 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 758793005008 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793005009 MarR family; Region: MarR_2; pfam12802 758793005010 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793005011 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 758793005012 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793005013 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793005014 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 758793005015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793005016 putative substrate translocation pore; other site 758793005017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793005018 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 758793005019 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 758793005020 RNA binding site [nucleotide binding]; other site 758793005021 active site 758793005022 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 758793005023 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 758793005024 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 758793005025 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 758793005026 translation initiation factor IF-2; Region: IF-2; TIGR00487 758793005027 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 758793005028 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 758793005029 G1 box; other site 758793005030 putative GEF interaction site [polypeptide binding]; other site 758793005031 GTP/Mg2+ binding site [chemical binding]; other site 758793005032 Switch I region; other site 758793005033 G2 box; other site 758793005034 G3 box; other site 758793005035 Switch II region; other site 758793005036 G4 box; other site 758793005037 G5 box; other site 758793005038 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 758793005039 Translation-initiation factor 2; Region: IF-2; pfam11987 758793005040 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 758793005041 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 758793005042 NusA N-terminal domain; Region: NusA_N; pfam08529 758793005043 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 758793005044 RNA binding site [nucleotide binding]; other site 758793005045 homodimer interface [polypeptide binding]; other site 758793005046 NusA-like KH domain; Region: KH_5; pfam13184 758793005047 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 758793005048 G-X-X-G motif; other site 758793005049 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 758793005050 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 758793005051 ribosome maturation protein RimP; Reviewed; Region: PRK00092 758793005052 hypothetical protein; Provisional; Region: PRK14641 758793005053 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 758793005054 putative oligomer interface [polypeptide binding]; other site 758793005055 putative RNA binding site [nucleotide binding]; other site 758793005056 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 758793005057 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793005058 RNA binding surface [nucleotide binding]; other site 758793005059 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 758793005060 probable active site [active] 758793005061 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 758793005062 aspartate aminotransferase; Provisional; Region: PRK06108 758793005063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793005064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793005065 homodimer interface [polypeptide binding]; other site 758793005066 catalytic residue [active] 758793005067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793005068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793005069 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 758793005070 putative dimerization interface [polypeptide binding]; other site 758793005071 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 758793005072 Uncharacterized conserved protein [Function unknown]; Region: COG1434 758793005073 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 758793005074 putative active site [active] 758793005075 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 758793005076 putative active site pocket [active] 758793005077 dimerization interface [polypeptide binding]; other site 758793005078 putative catalytic residue [active] 758793005079 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758793005080 Helix-turn-helix domain; Region: HTH_18; pfam12833 758793005081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793005082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793005083 Coenzyme A binding pocket [chemical binding]; other site 758793005084 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 758793005085 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 758793005086 HIGH motif; other site 758793005087 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 758793005088 active site 758793005089 KMSKS motif; other site 758793005090 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 758793005091 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 758793005092 nucleophile elbow; other site 758793005093 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793005094 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793005095 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 758793005096 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793005097 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793005098 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793005099 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793005100 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793005101 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793005102 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 758793005103 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 758793005104 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793005105 catalytic loop [active] 758793005106 iron binding site [ion binding]; other site 758793005107 chaperone protein HscA; Provisional; Region: hscA; PRK05183 758793005108 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 758793005109 nucleotide binding site [chemical binding]; other site 758793005110 putative NEF/HSP70 interaction site [polypeptide binding]; other site 758793005111 SBD interface [polypeptide binding]; other site 758793005112 co-chaperone HscB; Provisional; Region: hscB; PRK03578 758793005113 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 758793005114 HSP70 interaction site [polypeptide binding]; other site 758793005115 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 758793005116 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 758793005117 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 758793005118 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 758793005119 trimerization site [polypeptide binding]; other site 758793005120 active site 758793005121 cysteine desulfurase; Provisional; Region: PRK14012 758793005122 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 758793005123 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793005124 catalytic residue [active] 758793005125 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 758793005126 Rrf2 family protein; Region: rrf2_super; TIGR00738 758793005127 Low molecular weight phosphatase family; Region: LMWPc; cd00115 758793005128 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 758793005129 active site 758793005130 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 758793005131 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 758793005132 nucleophile elbow; other site 758793005133 Patatin phospholipase; Region: DUF3734; pfam12536 758793005134 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 758793005135 classical (c) SDRs; Region: SDR_c; cd05233 758793005136 NAD(P) binding site [chemical binding]; other site 758793005137 active site 758793005138 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 758793005139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 758793005140 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 758793005141 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 758793005142 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 758793005143 DNA binding residues [nucleotide binding] 758793005144 dimer interface [polypeptide binding]; other site 758793005145 copper binding site [ion binding]; other site 758793005146 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758793005147 metal-binding site [ion binding] 758793005148 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 758793005149 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 758793005150 NADP binding site [chemical binding]; other site 758793005151 active site 758793005152 putative substrate binding site [chemical binding]; other site 758793005153 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 758793005154 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 758793005155 putative active site [active] 758793005156 putative PHP Thumb interface [polypeptide binding]; other site 758793005157 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 758793005158 generic binding surface II; other site 758793005159 generic binding surface I; other site 758793005160 DNA Polymerase Y-family; Region: PolY_like; cd03468 758793005161 active site 758793005162 DNA binding site [nucleotide binding] 758793005163 Uncharacterized conserved protein [Function unknown]; Region: COG4544 758793005164 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 758793005165 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 758793005166 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793005167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793005168 DNA binding residues [nucleotide binding] 758793005169 dimerization interface [polypeptide binding]; other site 758793005170 Predicted membrane protein [Function unknown]; Region: COG3235 758793005171 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 758793005172 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 758793005173 putative active site [active] 758793005174 Zn binding site [ion binding]; other site 758793005175 hypothetical protein; Validated; Region: PRK02101 758793005176 PIN domain; Region: PIN_3; pfam13470 758793005177 methionine aminotransferase; Validated; Region: PRK09082 758793005178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793005179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793005180 homodimer interface [polypeptide binding]; other site 758793005181 catalytic residue [active] 758793005182 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 758793005183 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793005184 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793005185 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793005186 enoyl-CoA hydratase; Provisional; Region: PRK07511 758793005187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793005188 substrate binding site [chemical binding]; other site 758793005189 oxyanion hole (OAH) forming residues; other site 758793005190 trimer interface [polypeptide binding]; other site 758793005191 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 758793005192 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 758793005193 catalytic core [active] 758793005194 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 758793005195 putative active site [active] 758793005196 putative substrate binding site [chemical binding]; other site 758793005197 ATP binding site [chemical binding]; other site 758793005198 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793005199 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793005200 active site 758793005201 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 758793005202 putative active site [active] 758793005203 putative catalytic site [active] 758793005204 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 758793005205 putative active site [active] 758793005206 putative catalytic site [active] 758793005207 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 758793005208 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 758793005209 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 758793005210 dimer interface [polypeptide binding]; other site 758793005211 ADP-ribose binding site [chemical binding]; other site 758793005212 active site 758793005213 nudix motif; other site 758793005214 metal binding site [ion binding]; metal-binding site 758793005215 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 758793005216 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 758793005217 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 758793005218 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 758793005219 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 758793005220 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 758793005221 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 758793005222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 758793005223 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 758793005224 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 758793005225 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 758793005226 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 758793005227 4Fe-4S binding domain; Region: Fer4; pfam00037 758793005228 4Fe-4S binding domain; Region: Fer4; pfam00037 758793005229 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 758793005230 NADH dehydrogenase subunit G; Validated; Region: PRK09129 758793005231 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793005232 catalytic loop [active] 758793005233 iron binding site [ion binding]; other site 758793005234 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 758793005235 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 758793005236 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 758793005237 SLBB domain; Region: SLBB; pfam10531 758793005238 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 758793005239 NADH dehydrogenase subunit E; Validated; Region: PRK07539 758793005240 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 758793005241 putative dimer interface [polypeptide binding]; other site 758793005242 [2Fe-2S] cluster binding site [ion binding]; other site 758793005243 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 758793005244 NADH dehydrogenase subunit D; Validated; Region: PRK06075 758793005245 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 758793005246 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 758793005247 NADH dehydrogenase subunit B; Validated; Region: PRK06411 758793005248 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 758793005249 Preprotein translocase SecG subunit; Region: SecG; pfam03840 758793005250 triosephosphate isomerase; Provisional; Region: PRK14567 758793005251 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 758793005252 substrate binding site [chemical binding]; other site 758793005253 dimer interface [polypeptide binding]; other site 758793005254 catalytic triad [active] 758793005255 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 758793005256 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 758793005257 NAD(P) binding site [chemical binding]; other site 758793005258 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 758793005259 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 758793005260 RNase E interface [polypeptide binding]; other site 758793005261 trimer interface [polypeptide binding]; other site 758793005262 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 758793005263 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 758793005264 RNase E interface [polypeptide binding]; other site 758793005265 trimer interface [polypeptide binding]; other site 758793005266 active site 758793005267 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 758793005268 putative nucleic acid binding region [nucleotide binding]; other site 758793005269 G-X-X-G motif; other site 758793005270 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 758793005271 RNA binding site [nucleotide binding]; other site 758793005272 domain interface; other site 758793005273 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 758793005274 16S/18S rRNA binding site [nucleotide binding]; other site 758793005275 S13e-L30e interaction site [polypeptide binding]; other site 758793005276 25S rRNA binding site [nucleotide binding]; other site 758793005277 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793005278 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 758793005279 putative ligand binding site [chemical binding]; other site 758793005280 2-isopropylmalate synthase; Validated; Region: PRK00915 758793005281 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 758793005282 active site 758793005283 catalytic residues [active] 758793005284 metal binding site [ion binding]; metal-binding site 758793005285 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 758793005286 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 758793005287 NlpC/P60 family; Region: NLPC_P60; pfam00877 758793005288 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 758793005289 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793005290 Walker A/P-loop; other site 758793005291 ATP binding site [chemical binding]; other site 758793005292 Q-loop/lid; other site 758793005293 ABC transporter signature motif; other site 758793005294 Walker B; other site 758793005295 D-loop; other site 758793005296 H-loop/switch region; other site 758793005297 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793005298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793005299 Walker A/P-loop; other site 758793005300 ATP binding site [chemical binding]; other site 758793005301 Q-loop/lid; other site 758793005302 ABC transporter signature motif; other site 758793005303 Walker B; other site 758793005304 D-loop; other site 758793005305 H-loop/switch region; other site 758793005306 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 758793005307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793005308 dimer interface [polypeptide binding]; other site 758793005309 conserved gate region; other site 758793005310 putative PBP binding loops; other site 758793005311 ABC-ATPase subunit interface; other site 758793005312 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 758793005313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793005314 dimer interface [polypeptide binding]; other site 758793005315 conserved gate region; other site 758793005316 putative PBP binding loops; other site 758793005317 ABC-ATPase subunit interface; other site 758793005318 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 758793005319 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 758793005320 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 758793005321 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 758793005322 NAD binding site [chemical binding]; other site 758793005323 homotetramer interface [polypeptide binding]; other site 758793005324 homodimer interface [polypeptide binding]; other site 758793005325 substrate binding site [chemical binding]; other site 758793005326 active site 758793005327 benzoate transport; Region: 2A0115; TIGR00895 758793005328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793005329 putative substrate translocation pore; other site 758793005330 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793005331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793005332 DNA-binding site [nucleotide binding]; DNA binding site 758793005333 FCD domain; Region: FCD; pfam07729 758793005334 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 758793005335 Coenzyme A transferase; Region: CoA_trans; cl17247 758793005336 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 758793005337 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 758793005338 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 758793005339 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 758793005340 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 758793005341 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 758793005342 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 758793005343 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 758793005344 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 758793005345 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 758793005346 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 758793005347 aspartate kinase; Reviewed; Region: PRK06635 758793005348 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 758793005349 putative nucleotide binding site [chemical binding]; other site 758793005350 putative catalytic residues [active] 758793005351 putative Mg ion binding site [ion binding]; other site 758793005352 putative aspartate binding site [chemical binding]; other site 758793005353 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 758793005354 putative allosteric regulatory site; other site 758793005355 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 758793005356 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 758793005357 Ligand Binding Site [chemical binding]; other site 758793005358 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 758793005359 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 758793005360 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 758793005361 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 758793005362 endonuclease III; Region: ENDO3c; smart00478 758793005363 minor groove reading motif; other site 758793005364 helix-hairpin-helix signature motif; other site 758793005365 substrate binding pocket [chemical binding]; other site 758793005366 active site 758793005367 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 758793005368 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 758793005369 active site 758793005370 HIGH motif; other site 758793005371 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 758793005372 KMSKS motif; other site 758793005373 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 758793005374 tRNA binding surface [nucleotide binding]; other site 758793005375 anticodon binding site; other site 758793005376 TPR repeat; Region: TPR_11; pfam13414 758793005377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793005378 binding surface 758793005379 TPR motif; other site 758793005380 Tetratricopeptide repeat; Region: TPR_16; pfam13432 758793005381 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 758793005382 substrate binding site [chemical binding]; other site 758793005383 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 758793005384 substrate binding site [chemical binding]; other site 758793005385 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 758793005386 putative active site [active] 758793005387 putative metal binding site [ion binding]; other site 758793005388 serine O-acetyltransferase; Region: cysE; TIGR01172 758793005389 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 758793005390 trimer interface [polypeptide binding]; other site 758793005391 active site 758793005392 substrate binding site [chemical binding]; other site 758793005393 CoA binding site [chemical binding]; other site 758793005394 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 758793005395 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 758793005396 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 758793005397 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 758793005398 active site 758793005399 dimerization interface [polypeptide binding]; other site 758793005400 lysophospholipid transporter LplT; Provisional; Region: PRK11195 758793005401 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 758793005402 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 758793005403 MutS domain I; Region: MutS_I; pfam01624 758793005404 MutS domain II; Region: MutS_II; pfam05188 758793005405 MutS domain III; Region: MutS_III; pfam05192 758793005406 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 758793005407 Walker A/P-loop; other site 758793005408 ATP binding site [chemical binding]; other site 758793005409 Q-loop/lid; other site 758793005410 ABC transporter signature motif; other site 758793005411 Walker B; other site 758793005412 D-loop; other site 758793005413 H-loop/switch region; other site 758793005414 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 758793005415 Uncharacterized conserved protein [Function unknown]; Region: COG2850 758793005416 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 758793005417 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 758793005418 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 758793005419 ATP binding site [chemical binding]; other site 758793005420 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 758793005421 dihydrodipicolinate synthase; Region: dapA; TIGR00674 758793005422 dimer interface [polypeptide binding]; other site 758793005423 active site 758793005424 catalytic residue [active] 758793005425 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793005426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793005427 S-adenosylmethionine binding site [chemical binding]; other site 758793005428 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 758793005429 active site 758793005430 HIGH motif; other site 758793005431 dimer interface [polypeptide binding]; other site 758793005432 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 758793005433 active site 758793005434 KMSKS motif; other site 758793005435 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 758793005436 Peptidase family M50; Region: Peptidase_M50; pfam02163 758793005437 active site 758793005438 putative substrate binding region [chemical binding]; other site 758793005439 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 758793005440 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 758793005441 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 758793005442 active site 758793005443 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 758793005444 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793005445 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793005446 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 758793005447 catalytic site [active] 758793005448 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 758793005449 dinuclear metal binding motif [ion binding]; other site 758793005450 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 758793005451 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 758793005452 trimer interface [polypeptide binding]; other site 758793005453 putative metal binding site [ion binding]; other site 758793005454 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 758793005455 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 758793005456 dimerization interface [polypeptide binding]; other site 758793005457 domain crossover interface; other site 758793005458 redox-dependent activation switch; other site 758793005459 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 758793005460 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 758793005461 enolase; Provisional; Region: eno; PRK00077 758793005462 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 758793005463 dimer interface [polypeptide binding]; other site 758793005464 metal binding site [ion binding]; metal-binding site 758793005465 substrate binding pocket [chemical binding]; other site 758793005466 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 758793005467 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 758793005468 CTP synthetase; Validated; Region: pyrG; PRK05380 758793005469 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 758793005470 Catalytic site [active] 758793005471 active site 758793005472 UTP binding site [chemical binding]; other site 758793005473 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 758793005474 active site 758793005475 putative oxyanion hole; other site 758793005476 catalytic triad [active] 758793005477 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793005478 PGAP1-like protein; Region: PGAP1; pfam07819 758793005479 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 758793005480 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 758793005481 Competence protein; Region: Competence; pfam03772 758793005482 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 758793005483 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793005484 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 758793005485 active site 758793005486 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 758793005487 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758793005488 Walker A/P-loop; other site 758793005489 ATP binding site [chemical binding]; other site 758793005490 Q-loop/lid; other site 758793005491 ABC transporter signature motif; other site 758793005492 Walker B; other site 758793005493 D-loop; other site 758793005494 H-loop/switch region; other site 758793005495 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758793005496 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 758793005497 FtsX-like permease family; Region: FtsX; pfam02687 758793005498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 758793005499 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 758793005500 DHH family; Region: DHH; pfam01368 758793005501 DHHA1 domain; Region: DHHA1; pfam02272 758793005502 peptide chain release factor 2; Provisional; Region: PRK08787 758793005503 This domain is found in peptide chain release factors; Region: PCRF; smart00937 758793005504 RF-1 domain; Region: RF-1; pfam00472 758793005505 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 758793005506 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 758793005507 dimer interface [polypeptide binding]; other site 758793005508 putative anticodon binding site; other site 758793005509 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 758793005510 motif 1; other site 758793005511 active site 758793005512 motif 2; other site 758793005513 motif 3; other site 758793005514 Predicted kinase [General function prediction only]; Region: COG0645 758793005515 AAA domain; Region: AAA_17; pfam13207 758793005516 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 758793005517 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 758793005518 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 758793005519 ketol-acid reductoisomerase; Provisional; Region: PRK05479 758793005520 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 758793005521 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 758793005522 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 758793005523 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 758793005524 putative valine binding site [chemical binding]; other site 758793005525 dimer interface [polypeptide binding]; other site 758793005526 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 758793005527 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 758793005528 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793005529 PYR/PP interface [polypeptide binding]; other site 758793005530 dimer interface [polypeptide binding]; other site 758793005531 TPP binding site [chemical binding]; other site 758793005532 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793005533 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 758793005534 TPP-binding site [chemical binding]; other site 758793005535 dimer interface [polypeptide binding]; other site 758793005536 RNA polymerase factor sigma-70; Validated; Region: PRK09047 758793005537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793005538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793005539 DNA binding residues [nucleotide binding] 758793005540 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 758793005541 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 758793005542 RDD family; Region: RDD; pfam06271 758793005543 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758793005544 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 758793005545 putative active site [active] 758793005546 putative metal binding site [ion binding]; other site 758793005547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793005548 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 758793005549 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 758793005550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793005551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793005552 Bacterial transcriptional repressor; Region: TetR; pfam13972 758793005553 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 758793005554 glucose-1-dehydrogenase; Provisional; Region: PRK06947 758793005555 classical (c) SDRs; Region: SDR_c; cd05233 758793005556 NAD(P) binding site [chemical binding]; other site 758793005557 active site 758793005558 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 758793005559 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 758793005560 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 758793005561 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 758793005562 apolar tunnel; other site 758793005563 heme binding site [chemical binding]; other site 758793005564 dimerization interface [polypeptide binding]; other site 758793005565 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 758793005566 FtsX-like permease family; Region: FtsX; pfam02687 758793005567 FtsX-like permease family; Region: FtsX; pfam02687 758793005568 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 758793005569 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 758793005570 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 758793005571 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 758793005572 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 758793005573 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 758793005574 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 758793005575 catalytic triad [active] 758793005576 EAL domain; Region: EAL; pfam00563 758793005577 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793005578 PAS domain; Region: PAS_9; pfam13426 758793005579 putative active site [active] 758793005580 heme pocket [chemical binding]; other site 758793005581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793005582 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793005583 metal binding site [ion binding]; metal-binding site 758793005584 active site 758793005585 I-site; other site 758793005586 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793005587 HDOD domain; Region: HDOD; pfam08668 758793005588 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758793005589 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758793005590 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793005591 dimer interface [polypeptide binding]; other site 758793005592 putative CheW interface [polypeptide binding]; other site 758793005593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793005594 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793005595 putative substrate translocation pore; other site 758793005596 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 758793005597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793005598 acyl-activating enzyme (AAE) consensus motif; other site 758793005599 AMP binding site [chemical binding]; other site 758793005600 active site 758793005601 CoA binding site [chemical binding]; other site 758793005602 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 758793005603 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 758793005604 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 758793005605 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 758793005606 Part of AAA domain; Region: AAA_19; pfam13245 758793005607 Family description; Region: UvrD_C_2; pfam13538 758793005608 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 758793005609 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 758793005610 HIGH motif; other site 758793005611 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 758793005612 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 758793005613 active site 758793005614 KMSKS motif; other site 758793005615 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 758793005616 tRNA binding surface [nucleotide binding]; other site 758793005617 anticodon binding site; other site 758793005618 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 758793005619 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 758793005620 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 758793005621 active site 758793005622 tetramer interface; other site 758793005623 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 758793005624 CPxP motif; other site 758793005625 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793005626 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793005627 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793005628 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793005629 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793005630 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793005631 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758793005632 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758793005633 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758793005634 putative active site [active] 758793005635 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 758793005636 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793005637 putative ligand binding site [chemical binding]; other site 758793005638 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793005639 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793005640 TM-ABC transporter signature motif; other site 758793005641 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793005642 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793005643 Walker A/P-loop; other site 758793005644 ATP binding site [chemical binding]; other site 758793005645 Q-loop/lid; other site 758793005646 ABC transporter signature motif; other site 758793005647 Walker B; other site 758793005648 D-loop; other site 758793005649 H-loop/switch region; other site 758793005650 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793005651 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 758793005652 substrate binding site [chemical binding]; other site 758793005653 ATP binding site [chemical binding]; other site 758793005654 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 758793005655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 758793005656 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 758793005657 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793005658 PYR/PP interface [polypeptide binding]; other site 758793005659 dimer interface [polypeptide binding]; other site 758793005660 TPP binding site [chemical binding]; other site 758793005661 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793005662 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 758793005663 TPP-binding site [chemical binding]; other site 758793005664 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 758793005665 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 758793005666 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793005667 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793005668 Walker A/P-loop; other site 758793005669 ATP binding site [chemical binding]; other site 758793005670 Q-loop/lid; other site 758793005671 ABC transporter signature motif; other site 758793005672 Walker B; other site 758793005673 D-loop; other site 758793005674 H-loop/switch region; other site 758793005675 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793005676 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793005677 Walker A/P-loop; other site 758793005678 ATP binding site [chemical binding]; other site 758793005679 Q-loop/lid; other site 758793005680 ABC transporter signature motif; other site 758793005681 Walker B; other site 758793005682 D-loop; other site 758793005683 H-loop/switch region; other site 758793005684 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793005685 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793005686 TM-ABC transporter signature motif; other site 758793005687 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793005688 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793005689 TM-ABC transporter signature motif; other site 758793005690 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758793005691 active site 758793005692 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 758793005693 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 758793005694 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 758793005695 tetramer interface [polypeptide binding]; other site 758793005696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793005697 catalytic residue [active] 758793005698 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 758793005699 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 758793005700 motif 1; other site 758793005701 active site 758793005702 motif 2; other site 758793005703 motif 3; other site 758793005704 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 758793005705 DHHA1 domain; Region: DHHA1; pfam02272 758793005706 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793005707 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793005708 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 758793005709 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 758793005710 active site 758793005711 HIGH motif; other site 758793005712 nucleotide binding site [chemical binding]; other site 758793005713 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 758793005714 KMSKS motif; other site 758793005715 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 758793005716 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 758793005717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793005718 substrate binding pocket [chemical binding]; other site 758793005719 membrane-bound complex binding site; other site 758793005720 hinge residues; other site 758793005721 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 758793005722 nudix motif; other site 758793005723 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 758793005724 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 758793005725 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 758793005726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793005727 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 758793005728 DNA-binding site [nucleotide binding]; DNA binding site 758793005729 FCD domain; Region: FCD; pfam07729 758793005730 cytosine deaminase; Provisional; Region: PRK05985 758793005731 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 758793005732 active site 758793005733 putative cyanate transporter; Provisional; Region: cynX; PRK09705 758793005734 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 758793005735 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 758793005736 active site 758793005737 catalytic residues [active] 758793005738 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 758793005739 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758793005740 Peptidase family M23; Region: Peptidase_M23; pfam01551 758793005741 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 758793005742 catalytic core [active] 758793005743 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 758793005744 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 758793005745 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 758793005746 polyphosphate kinase; Provisional; Region: PRK05443 758793005747 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 758793005748 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 758793005749 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 758793005750 putative active site [active] 758793005751 catalytic site [active] 758793005752 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 758793005753 putative domain interface [polypeptide binding]; other site 758793005754 putative active site [active] 758793005755 catalytic site [active] 758793005756 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 758793005757 PAS domain; Region: PAS; smart00091 758793005758 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793005759 dimer interface [polypeptide binding]; other site 758793005760 phosphorylation site [posttranslational modification] 758793005761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793005762 ATP binding site [chemical binding]; other site 758793005763 Mg2+ binding site [ion binding]; other site 758793005764 G-X-G motif; other site 758793005765 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 758793005766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793005767 active site 758793005768 phosphorylation site [posttranslational modification] 758793005769 intermolecular recognition site; other site 758793005770 dimerization interface [polypeptide binding]; other site 758793005771 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793005772 DNA binding site [nucleotide binding] 758793005773 transcriptional regulator PhoU; Provisional; Region: PRK11115 758793005774 PhoU domain; Region: PhoU; pfam01895 758793005775 PhoU domain; Region: PhoU; pfam01895 758793005776 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 758793005777 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 758793005778 Walker A/P-loop; other site 758793005779 ATP binding site [chemical binding]; other site 758793005780 Q-loop/lid; other site 758793005781 ABC transporter signature motif; other site 758793005782 Walker B; other site 758793005783 D-loop; other site 758793005784 H-loop/switch region; other site 758793005785 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 758793005786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793005787 dimer interface [polypeptide binding]; other site 758793005788 conserved gate region; other site 758793005789 putative PBP binding loops; other site 758793005790 ABC-ATPase subunit interface; other site 758793005791 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 758793005792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793005793 dimer interface [polypeptide binding]; other site 758793005794 conserved gate region; other site 758793005795 putative PBP binding loops; other site 758793005796 ABC-ATPase subunit interface; other site 758793005797 PBP superfamily domain; Region: PBP_like_2; cl17296 758793005798 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 758793005799 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 758793005800 active site 758793005801 substrate binding site [chemical binding]; other site 758793005802 metal binding site [ion binding]; metal-binding site 758793005803 dihydropteroate synthase; Region: DHPS; TIGR01496 758793005804 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 758793005805 substrate binding pocket [chemical binding]; other site 758793005806 dimer interface [polypeptide binding]; other site 758793005807 inhibitor binding site; inhibition site 758793005808 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 758793005809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793005810 Walker A motif; other site 758793005811 ATP binding site [chemical binding]; other site 758793005812 Walker B motif; other site 758793005813 arginine finger; other site 758793005814 Peptidase family M41; Region: Peptidase_M41; pfam01434 758793005815 FtsJ-like methyltransferase; Region: FtsJ; cl17430 758793005816 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 758793005817 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 758793005818 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 758793005819 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 758793005820 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 758793005821 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 758793005822 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 758793005823 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758793005824 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 758793005825 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 758793005826 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758793005827 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793005828 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 758793005829 IMP binding site; other site 758793005830 dimer interface [polypeptide binding]; other site 758793005831 interdomain contacts; other site 758793005832 partial ornithine binding site; other site 758793005833 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 758793005834 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 758793005835 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 758793005836 catalytic site [active] 758793005837 subunit interface [polypeptide binding]; other site 758793005838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793005839 putative substrate translocation pore; other site 758793005840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793005841 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 758793005842 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793005843 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793005844 catalytic residue [active] 758793005845 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 758793005846 LysM domain; Region: LysM; pfam01476 758793005847 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 758793005848 Methyltransferase domain; Region: Methyltransf_11; pfam08241 758793005849 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 758793005850 RNA/DNA hybrid binding site [nucleotide binding]; other site 758793005851 active site 758793005852 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 758793005853 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 758793005854 active site 758793005855 catalytic site [active] 758793005856 substrate binding site [chemical binding]; other site 758793005857 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 758793005858 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 758793005859 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793005860 putative ADP-binding pocket [chemical binding]; other site 758793005861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 758793005862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758793005863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793005864 Walker A/P-loop; other site 758793005865 ATP binding site [chemical binding]; other site 758793005866 Q-loop/lid; other site 758793005867 ABC transporter signature motif; other site 758793005868 Walker B; other site 758793005869 D-loop; other site 758793005870 H-loop/switch region; other site 758793005871 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 758793005872 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 758793005873 active site 758793005874 homotetramer interface [polypeptide binding]; other site 758793005875 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 758793005876 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 758793005877 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 758793005878 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 758793005879 Cu(I) binding site [ion binding]; other site 758793005880 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 758793005881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758793005882 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 758793005883 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 758793005884 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 758793005885 GIY-YIG motif/motif A; other site 758793005886 active site 758793005887 catalytic site [active] 758793005888 putative DNA binding site [nucleotide binding]; other site 758793005889 metal binding site [ion binding]; metal-binding site 758793005890 UvrB/uvrC motif; Region: UVR; pfam02151 758793005891 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 758793005892 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 758793005893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 758793005894 elongation factor P; Validated; Region: PRK00529 758793005895 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 758793005896 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 758793005897 RNA binding site [nucleotide binding]; other site 758793005898 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 758793005899 RNA binding site [nucleotide binding]; other site 758793005900 BON domain; Region: BON; pfam04972 758793005901 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 758793005902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793005903 active site 758793005904 phosphorylation site [posttranslational modification] 758793005905 intermolecular recognition site; other site 758793005906 dimerization interface [polypeptide binding]; other site 758793005907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793005908 Walker A motif; other site 758793005909 ATP binding site [chemical binding]; other site 758793005910 Walker B motif; other site 758793005911 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793005912 beta-hexosaminidase; Provisional; Region: PRK05337 758793005913 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 758793005914 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 758793005915 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 758793005916 active site 758793005917 hydrophilic channel; other site 758793005918 dimerization interface [polypeptide binding]; other site 758793005919 catalytic residues [active] 758793005920 active site lid [active] 758793005921 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 758793005922 Recombination protein O N terminal; Region: RecO_N; pfam11967 758793005923 Recombination protein O C terminal; Region: RecO_C; pfam02565 758793005924 GTPase Era; Reviewed; Region: era; PRK00089 758793005925 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 758793005926 G1 box; other site 758793005927 GTP/Mg2+ binding site [chemical binding]; other site 758793005928 Switch I region; other site 758793005929 G2 box; other site 758793005930 Switch II region; other site 758793005931 G3 box; other site 758793005932 G4 box; other site 758793005933 G5 box; other site 758793005934 KH domain; Region: KH_2; pfam07650 758793005935 ribonuclease III; Reviewed; Region: PRK12372 758793005936 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 758793005937 dimerization interface [polypeptide binding]; other site 758793005938 active site 758793005939 metal binding site [ion binding]; metal-binding site 758793005940 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 758793005941 signal peptidase I; Provisional; Region: PRK10861 758793005942 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 758793005943 Catalytic site [active] 758793005944 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 758793005945 GTP-binding protein LepA; Provisional; Region: PRK05433 758793005946 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 758793005947 G1 box; other site 758793005948 putative GEF interaction site [polypeptide binding]; other site 758793005949 GTP/Mg2+ binding site [chemical binding]; other site 758793005950 Switch I region; other site 758793005951 G2 box; other site 758793005952 G3 box; other site 758793005953 Switch II region; other site 758793005954 G4 box; other site 758793005955 G5 box; other site 758793005956 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 758793005957 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 758793005958 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 758793005959 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 758793005960 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 758793005961 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 758793005962 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 758793005963 protein binding site [polypeptide binding]; other site 758793005964 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 758793005965 protein binding site [polypeptide binding]; other site 758793005966 anti-sigma E factor; Provisional; Region: rseB; PRK09455 758793005967 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 758793005968 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 758793005969 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 758793005970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793005971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793005972 DNA binding residues [nucleotide binding] 758793005973 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 758793005974 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 758793005975 dimer interface [polypeptide binding]; other site 758793005976 active site 758793005977 acyl carrier protein; Provisional; Region: acpP; PRK00982 758793005978 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793005979 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 758793005980 NAD(P) binding site [chemical binding]; other site 758793005981 homotetramer interface [polypeptide binding]; other site 758793005982 homodimer interface [polypeptide binding]; other site 758793005983 active site 758793005984 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 758793005985 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 758793005986 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 758793005987 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 758793005988 dimer interface [polypeptide binding]; other site 758793005989 active site 758793005990 CoA binding pocket [chemical binding]; other site 758793005991 putative phosphate acyltransferase; Provisional; Region: PRK05331 758793005992 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 758793005993 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 758793005994 Maf-like protein; Region: Maf; pfam02545 758793005995 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 758793005996 active site 758793005997 dimer interface [polypeptide binding]; other site 758793005998 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 758793005999 putative SAM binding site [chemical binding]; other site 758793006000 homodimer interface [polypeptide binding]; other site 758793006001 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 758793006002 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 758793006003 tandem repeat interface [polypeptide binding]; other site 758793006004 oligomer interface [polypeptide binding]; other site 758793006005 active site residues [active] 758793006006 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 758793006007 iron-sulfur cluster [ion binding]; other site 758793006008 [2Fe-2S] cluster binding site [ion binding]; other site 758793006009 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 758793006010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793006011 motif II; other site 758793006012 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 758793006013 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793006014 RNA binding surface [nucleotide binding]; other site 758793006015 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 758793006016 active site 758793006017 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 758793006018 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 758793006019 homodimer interface [polypeptide binding]; other site 758793006020 oligonucleotide binding site [chemical binding]; other site 758793006021 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 758793006022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793006023 FeS/SAM binding site; other site 758793006024 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 758793006025 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 758793006026 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 758793006027 GTP binding site; other site 758793006028 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 758793006029 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 758793006030 dimer interface [polypeptide binding]; other site 758793006031 putative functional site; other site 758793006032 putative MPT binding site; other site 758793006033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758793006034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793006035 Coenzyme A binding pocket [chemical binding]; other site 758793006036 RmuC family; Region: RmuC; pfam02646 758793006037 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 758793006038 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 758793006039 dimerization interface [polypeptide binding]; other site 758793006040 ligand binding site [chemical binding]; other site 758793006041 NADP binding site [chemical binding]; other site 758793006042 catalytic site [active] 758793006043 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 758793006044 Uncharacterized conserved protein [Function unknown]; Region: COG1556 758793006045 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 758793006046 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 758793006047 active site 758793006048 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 758793006049 4Fe-4S binding domain; Region: Fer4; cl02805 758793006050 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 758793006051 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 758793006052 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 758793006053 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 758793006054 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 758793006055 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 758793006056 4Fe-4S binding domain; Region: Fer4; pfam00037 758793006057 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 758793006058 Cysteine-rich domain; Region: CCG; pfam02754 758793006059 Cysteine-rich domain; Region: CCG; pfam02754 758793006060 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 758793006061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793006062 DNA-binding site [nucleotide binding]; DNA binding site 758793006063 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758793006064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 758793006065 CreA protein; Region: CreA; pfam05981 758793006066 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758793006067 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793006068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793006069 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 758793006070 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 758793006071 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 758793006072 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 758793006073 Part of AAA domain; Region: AAA_19; pfam13245 758793006074 Family description; Region: UvrD_C_2; pfam13538 758793006075 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793006076 RNA binding surface [nucleotide binding]; other site 758793006077 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 758793006078 multidrug efflux protein; Reviewed; Region: PRK01766 758793006079 cation binding site [ion binding]; other site 758793006080 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 758793006081 putative active site [active] 758793006082 catalytic site [active] 758793006083 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 758793006084 PLD-like domain; Region: PLDc_2; pfam13091 758793006085 putative active site [active] 758793006086 catalytic site [active] 758793006087 fumarate hydratase; Reviewed; Region: fumC; PRK00485 758793006088 Class II fumarases; Region: Fumarase_classII; cd01362 758793006089 active site 758793006090 tetramer interface [polypeptide binding]; other site 758793006091 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 758793006092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793006093 dimerization interface [polypeptide binding]; other site 758793006094 putative DNA binding site [nucleotide binding]; other site 758793006095 putative Zn2+ binding site [ion binding]; other site 758793006096 thymidylate synthase; Provisional; Region: thyA; PRK13821 758793006097 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 758793006098 dimerization interface [polypeptide binding]; other site 758793006099 active site 758793006100 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 758793006101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793006102 Walker A motif; other site 758793006103 ATP binding site [chemical binding]; other site 758793006104 Walker B motif; other site 758793006105 arginine finger; other site 758793006106 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 758793006107 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 758793006108 folate binding site [chemical binding]; other site 758793006109 NADP+ binding site [chemical binding]; other site 758793006110 peptidase PmbA; Provisional; Region: PRK11040 758793006111 hypothetical protein; Provisional; Region: PRK05255 758793006112 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 758793006113 MPT binding site; other site 758793006114 trimer interface [polypeptide binding]; other site 758793006115 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 758793006116 catalytic site [active] 758793006117 putative active site [active] 758793006118 putative substrate binding site [chemical binding]; other site 758793006119 dimer interface [polypeptide binding]; other site 758793006120 Peptidase family M48; Region: Peptidase_M48; pfam01435 758793006121 GTPase RsgA; Reviewed; Region: PRK00098 758793006122 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 758793006123 RNA binding site [nucleotide binding]; other site 758793006124 homodimer interface [polypeptide binding]; other site 758793006125 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 758793006126 GTPase/Zn-binding domain interface [polypeptide binding]; other site 758793006127 GTP/Mg2+ binding site [chemical binding]; other site 758793006128 G4 box; other site 758793006129 G5 box; other site 758793006130 G1 box; other site 758793006131 Switch I region; other site 758793006132 G2 box; other site 758793006133 G3 box; other site 758793006134 Switch II region; other site 758793006135 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 758793006136 CobD/CbiB family protein; Provisional; Region: PRK07630 758793006137 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 758793006138 putative active site [active] 758793006139 putative CoA binding site [chemical binding]; other site 758793006140 nudix motif; other site 758793006141 metal binding site [ion binding]; metal-binding site 758793006142 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 758793006143 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 758793006144 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 758793006145 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 758793006146 RimM N-terminal domain; Region: RimM; pfam01782 758793006147 PRC-barrel domain; Region: PRC; pfam05239 758793006148 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 758793006149 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 758793006150 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793006151 FeS/SAM binding site; other site 758793006152 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 758793006153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793006154 putative DNA binding site [nucleotide binding]; other site 758793006155 putative Zn2+ binding site [ion binding]; other site 758793006156 AsnC family; Region: AsnC_trans_reg; pfam01037 758793006157 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 758793006158 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793006159 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 758793006160 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 758793006161 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793006162 active site 758793006163 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 758793006164 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 758793006165 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 758793006166 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 758793006167 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 758793006168 Ligand binding site [chemical binding]; other site 758793006169 Electron transfer flavoprotein domain; Region: ETF; pfam01012 758793006170 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 758793006171 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 758793006172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793006173 dimer interface [polypeptide binding]; other site 758793006174 conserved gate region; other site 758793006175 ABC-ATPase subunit interface; other site 758793006176 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 758793006177 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 758793006178 Walker A/P-loop; other site 758793006179 ATP binding site [chemical binding]; other site 758793006180 Q-loop/lid; other site 758793006181 ABC transporter signature motif; other site 758793006182 Walker B; other site 758793006183 D-loop; other site 758793006184 H-loop/switch region; other site 758793006185 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 758793006186 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 758793006187 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793006188 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 758793006189 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 758793006190 putative active site [active] 758793006191 Zn binding site [ion binding]; other site 758793006192 Transglycosylase SLT domain; Region: SLT_2; pfam13406 758793006193 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793006194 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793006195 cysteine synthase B; Region: cysM; TIGR01138 758793006196 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 758793006197 dimer interface [polypeptide binding]; other site 758793006198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793006199 catalytic residue [active] 758793006200 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 758793006201 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 758793006202 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 758793006203 NADP binding site [chemical binding]; other site 758793006204 homopentamer interface [polypeptide binding]; other site 758793006205 substrate binding site [chemical binding]; other site 758793006206 active site 758793006207 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 758793006208 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 758793006209 putative ribose interaction site [chemical binding]; other site 758793006210 putative ADP binding site [chemical binding]; other site 758793006211 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 758793006212 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 758793006213 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 758793006214 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 758793006215 tetratricopeptide repeat protein; Provisional; Region: PRK11788 758793006216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006217 binding surface 758793006218 TPR motif; other site 758793006219 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 758793006220 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 758793006221 IHF dimer interface [polypeptide binding]; other site 758793006222 IHF - DNA interface [nucleotide binding]; other site 758793006223 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 758793006224 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 758793006225 RNA binding site [nucleotide binding]; other site 758793006226 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 758793006227 RNA binding site [nucleotide binding]; other site 758793006228 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 758793006229 RNA binding site [nucleotide binding]; other site 758793006230 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 758793006231 RNA binding site [nucleotide binding]; other site 758793006232 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 758793006233 RNA binding site [nucleotide binding]; other site 758793006234 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 758793006235 RNA binding site [nucleotide binding]; other site 758793006236 cytidylate kinase; Provisional; Region: cmk; PRK00023 758793006237 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 758793006238 CMP-binding site; other site 758793006239 The sites determining sugar specificity; other site 758793006240 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 758793006241 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 758793006242 hinge; other site 758793006243 active site 758793006244 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 758793006245 prephenate dehydrogenase; Validated; Region: PRK08507 758793006246 Chorismate mutase type II; Region: CM_2; smart00830 758793006247 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 758793006248 Prephenate dehydratase; Region: PDT; pfam00800 758793006249 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 758793006250 putative L-Phe binding site [chemical binding]; other site 758793006251 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 758793006252 homodimer interface [polypeptide binding]; other site 758793006253 substrate-cofactor binding pocket; other site 758793006254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793006255 catalytic residue [active] 758793006256 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 758793006257 DNA gyrase subunit A; Validated; Region: PRK05560 758793006258 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 758793006259 CAP-like domain; other site 758793006260 active site 758793006261 primary dimer interface [polypeptide binding]; other site 758793006262 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758793006263 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758793006264 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758793006265 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758793006266 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758793006267 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 758793006268 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793006269 ligand binding site [chemical binding]; other site 758793006270 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 758793006271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793006272 S-adenosylmethionine binding site [chemical binding]; other site 758793006273 phosphoglycolate phosphatase; Provisional; Region: PRK13222 758793006274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793006275 motif II; other site 758793006276 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 758793006277 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 758793006278 putative sugar binding sites [chemical binding]; other site 758793006279 Q-X-W motif; other site 758793006280 Family description; Region: VCBS; pfam13517 758793006281 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793006282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006283 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 758793006284 PBP superfamily domain; Region: PBP_like; pfam12727 758793006285 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 758793006286 putative dimer interface [polypeptide binding]; other site 758793006287 [2Fe-2S] cluster binding site [ion binding]; other site 758793006288 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 758793006289 putative dimer interface [polypeptide binding]; other site 758793006290 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 758793006291 SLBB domain; Region: SLBB; pfam10531 758793006292 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 758793006293 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793006294 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 758793006295 catalytic loop [active] 758793006296 iron binding site [ion binding]; other site 758793006297 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 758793006298 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 758793006299 [4Fe-4S] binding site [ion binding]; other site 758793006300 molybdopterin cofactor binding site; other site 758793006301 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 758793006302 molybdopterin cofactor binding site; other site 758793006303 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 758793006304 hypothetical protein; Provisional; Region: PRK06184 758793006305 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793006306 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 758793006307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793006308 dimerization interface [polypeptide binding]; other site 758793006309 putative DNA binding site [nucleotide binding]; other site 758793006310 putative Zn2+ binding site [ion binding]; other site 758793006311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006312 binding surface 758793006313 TPR motif; other site 758793006314 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 758793006315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006316 binding surface 758793006317 TPR motif; other site 758793006318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006319 binding surface 758793006320 TPR motif; other site 758793006321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006322 binding surface 758793006323 TPR motif; other site 758793006324 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 758793006325 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 758793006326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793006327 substrate binding pocket [chemical binding]; other site 758793006328 membrane-bound complex binding site; other site 758793006329 hinge residues; other site 758793006330 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793006331 H-loop/switch region; other site 758793006332 citrate-proton symporter; Provisional; Region: PRK15075 758793006333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793006334 putative substrate translocation pore; other site 758793006335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758793006336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793006337 Coenzyme A binding pocket [chemical binding]; other site 758793006338 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 758793006339 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 758793006340 Peptidase C26; Region: Peptidase_C26; pfam07722 758793006341 catalytic triad [active] 758793006342 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 758793006343 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758793006344 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 758793006345 Nitrogen regulatory protein P-II; Region: P-II; smart00938 758793006346 NAD synthetase; Reviewed; Region: nadE; PRK02628 758793006347 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 758793006348 multimer interface [polypeptide binding]; other site 758793006349 active site 758793006350 catalytic triad [active] 758793006351 protein interface 1 [polypeptide binding]; other site 758793006352 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 758793006353 homodimer interface [polypeptide binding]; other site 758793006354 NAD binding pocket [chemical binding]; other site 758793006355 ATP binding pocket [chemical binding]; other site 758793006356 Mg binding site [ion binding]; other site 758793006357 active-site loop [active] 758793006358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 758793006359 Protein of unknown function, DUF482; Region: DUF482; pfam04339 758793006360 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 758793006361 GIY-YIG motif/motif A; other site 758793006362 putative active site [active] 758793006363 putative metal binding site [ion binding]; other site 758793006364 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 758793006365 dimer interface [polypeptide binding]; other site 758793006366 substrate binding site [chemical binding]; other site 758793006367 metal binding sites [ion binding]; metal-binding site 758793006368 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793006369 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 758793006370 NAD(P) binding site [chemical binding]; other site 758793006371 catalytic residues [active] 758793006372 catalytic residues [active] 758793006373 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 758793006374 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 758793006375 putative NAD(P) binding site [chemical binding]; other site 758793006376 active site 758793006377 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793006378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793006379 putative substrate translocation pore; other site 758793006380 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793006381 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 758793006382 putative ligand binding site [chemical binding]; other site 758793006383 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793006384 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793006385 TM-ABC transporter signature motif; other site 758793006386 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793006387 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793006388 TM-ABC transporter signature motif; other site 758793006389 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 758793006390 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793006391 Walker A/P-loop; other site 758793006392 ATP binding site [chemical binding]; other site 758793006393 Q-loop/lid; other site 758793006394 ABC transporter signature motif; other site 758793006395 Walker B; other site 758793006396 D-loop; other site 758793006397 H-loop/switch region; other site 758793006398 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 758793006399 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793006400 Walker A/P-loop; other site 758793006401 ATP binding site [chemical binding]; other site 758793006402 Q-loop/lid; other site 758793006403 ABC transporter signature motif; other site 758793006404 Walker B; other site 758793006405 D-loop; other site 758793006406 H-loop/switch region; other site 758793006407 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 758793006408 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793006409 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793006410 Cytochrome c; Region: Cytochrom_C; pfam00034 758793006411 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 758793006412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793006413 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793006414 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 758793006415 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793006416 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793006417 substrate binding pocket [chemical binding]; other site 758793006418 membrane-bound complex binding site; other site 758793006419 hinge residues; other site 758793006420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793006421 dimer interface [polypeptide binding]; other site 758793006422 conserved gate region; other site 758793006423 putative PBP binding loops; other site 758793006424 ABC-ATPase subunit interface; other site 758793006425 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793006427 dimer interface [polypeptide binding]; other site 758793006428 conserved gate region; other site 758793006429 putative PBP binding loops; other site 758793006430 ABC-ATPase subunit interface; other site 758793006431 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758793006432 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793006433 Walker A/P-loop; other site 758793006434 ATP binding site [chemical binding]; other site 758793006435 Q-loop/lid; other site 758793006436 ABC transporter signature motif; other site 758793006437 Walker B; other site 758793006438 D-loop; other site 758793006439 H-loop/switch region; other site 758793006440 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 758793006441 alpha-gamma subunit interface [polypeptide binding]; other site 758793006442 beta-gamma subunit interface [polypeptide binding]; other site 758793006443 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 758793006444 gamma-beta subunit interface [polypeptide binding]; other site 758793006445 alpha-beta subunit interface [polypeptide binding]; other site 758793006446 urease subunit alpha; Reviewed; Region: ureC; PRK13207 758793006447 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 758793006448 subunit interactions [polypeptide binding]; other site 758793006449 active site 758793006450 flap region; other site 758793006451 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 758793006452 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 758793006453 dimer interface [polypeptide binding]; other site 758793006454 catalytic residues [active] 758793006455 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 758793006456 UreF; Region: UreF; pfam01730 758793006457 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793006458 PAAR motif; Region: PAAR_motif; pfam05488 758793006459 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 758793006460 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 758793006461 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 758793006462 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 758793006463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 758793006464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006465 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 758793006466 putative ADP-binding pocket [chemical binding]; other site 758793006467 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 758793006468 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 758793006469 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793006470 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 758793006471 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 758793006472 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 758793006473 putative active site [active] 758793006474 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 758793006475 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 758793006476 active site 758793006477 substrate binding site [chemical binding]; other site 758793006478 metal binding site [ion binding]; metal-binding site 758793006479 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 758793006480 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 758793006481 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 758793006482 active site 758793006483 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 758793006484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006485 putative ADP-binding pocket [chemical binding]; other site 758793006486 UDP-glucose 4-epimerase; Region: PLN02240 758793006487 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 758793006488 NAD binding site [chemical binding]; other site 758793006489 homodimer interface [polypeptide binding]; other site 758793006490 active site 758793006491 substrate binding site [chemical binding]; other site 758793006492 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 758793006493 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 758793006494 Mg++ binding site [ion binding]; other site 758793006495 putative catalytic motif [active] 758793006496 Dienelactone hydrolase family; Region: DLH; pfam01738 758793006497 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793006498 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793006499 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793006500 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006501 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793006502 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 758793006503 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793006504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006505 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 758793006506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006507 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 758793006508 putative ADP-binding pocket [chemical binding]; other site 758793006509 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 758793006510 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793006511 putative acyl transferase; Provisional; Region: PRK10502 758793006512 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 758793006513 putative trimer interface [polypeptide binding]; other site 758793006514 putative active site [active] 758793006515 putative substrate binding site [chemical binding]; other site 758793006516 putative CoA binding site [chemical binding]; other site 758793006517 putative glycosyl transferase; Provisional; Region: PRK10307 758793006518 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 758793006519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006520 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793006521 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 758793006522 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 758793006523 NADP binding site [chemical binding]; other site 758793006524 active site 758793006525 putative substrate binding site [chemical binding]; other site 758793006526 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 758793006527 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 758793006528 NADP-binding site; other site 758793006529 homotetramer interface [polypeptide binding]; other site 758793006530 substrate binding site [chemical binding]; other site 758793006531 homodimer interface [polypeptide binding]; other site 758793006532 active site 758793006533 tyrosine kinase; Provisional; Region: PRK11519 758793006534 Chain length determinant protein; Region: Wzz; pfam02706 758793006535 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 758793006536 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793006537 polysaccharide export protein Wza; Provisional; Region: PRK15078 758793006538 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 758793006539 SLBB domain; Region: SLBB; pfam10531 758793006540 SLBB domain; Region: SLBB; pfam10531 758793006541 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 758793006542 Bacterial sugar transferase; Region: Bac_transf; pfam02397 758793006543 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 758793006544 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 758793006545 Substrate binding site; other site 758793006546 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 758793006547 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793006548 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 758793006549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793006550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793006551 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 758793006552 active site 758793006553 GDP-Mannose binding site [chemical binding]; other site 758793006554 dimer interface [polypeptide binding]; other site 758793006555 modified nudix motif 758793006556 metal binding site [ion binding]; metal-binding site 758793006557 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 758793006558 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 758793006559 active site 758793006560 tetramer interface; other site 758793006561 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793006562 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 758793006563 conserved cys residue [active] 758793006564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793006565 transcriptional regulator; Provisional; Region: PRK10632 758793006566 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793006567 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 758793006568 putative effector binding pocket; other site 758793006569 putative dimerization interface [polypeptide binding]; other site 758793006570 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793006571 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 758793006572 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793006573 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 758793006574 NAD(P) binding site [chemical binding]; other site 758793006575 homodimer interface [polypeptide binding]; other site 758793006576 substrate binding site [chemical binding]; other site 758793006577 active site 758793006578 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 758793006579 Mg++ binding site [ion binding]; other site 758793006580 putative catalytic motif [active] 758793006581 putative substrate binding site [chemical binding]; other site 758793006582 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793006583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793006584 NAD(P) binding site [chemical binding]; other site 758793006585 active site 758793006586 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 758793006587 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 758793006588 Probable Catalytic site; other site 758793006589 metal-binding site 758793006590 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 758793006591 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 758793006592 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 758793006593 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793006594 Putative Catalytic site; other site 758793006595 DXD motif; other site 758793006596 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 758793006597 DHHW protein; Region: DHHW; pfam14286 758793006598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793006599 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 758793006600 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 758793006601 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793006602 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793006603 active site 758793006604 Methyltransferase domain; Region: Methyltransf_24; pfam13578 758793006605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006606 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793006607 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793006608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793006609 active site 758793006610 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 758793006611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793006612 Q-loop/lid; other site 758793006613 ABC transporter signature motif; other site 758793006614 Walker B; other site 758793006615 D-loop; other site 758793006616 H-loop/switch region; other site 758793006617 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 758793006618 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758793006619 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 758793006620 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793006621 Probable Catalytic site; other site 758793006622 metal-binding site 758793006623 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 758793006624 active site 758793006625 Methyltransferase domain; Region: Methyltransf_24; pfam13578 758793006626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793006628 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 758793006629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793006630 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 758793006631 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 758793006632 Ligand binding site; other site 758793006633 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 758793006634 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 758793006635 NADP binding site [chemical binding]; other site 758793006636 active site 758793006637 putative substrate binding site [chemical binding]; other site 758793006638 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 758793006639 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 758793006640 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 758793006641 substrate binding site; other site 758793006642 tetramer interface; other site 758793006643 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 758793006644 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 758793006645 NAD binding site [chemical binding]; other site 758793006646 substrate binding site [chemical binding]; other site 758793006647 homodimer interface [polypeptide binding]; other site 758793006648 active site 758793006649 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 758793006650 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 758793006651 active site 758793006652 metal binding site [ion binding]; metal-binding site 758793006653 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758793006654 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758793006655 putative acyl-acceptor binding pocket; other site 758793006656 dihydroorotase; Provisional; Region: PRK07627 758793006657 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758793006658 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 758793006659 active site 758793006660 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 758793006661 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 758793006662 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 758793006663 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 758793006664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793006665 active site 758793006666 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 758793006667 hypothetical protein; Validated; Region: PRK00228 758793006668 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 758793006669 DNA photolyase; Region: DNA_photolyase; pfam00875 758793006670 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 758793006671 Rubredoxin; Region: Rubredoxin; pfam00301 758793006672 iron binding site [ion binding]; other site 758793006673 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 758793006674 dimer interface [polypeptide binding]; other site 758793006675 substrate binding site [chemical binding]; other site 758793006676 ATP binding site [chemical binding]; other site 758793006677 Protein of unknown function DUF72; Region: DUF72; pfam01904 758793006678 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 758793006679 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 758793006680 ring oligomerisation interface [polypeptide binding]; other site 758793006681 ATP/Mg binding site [chemical binding]; other site 758793006682 stacking interactions; other site 758793006683 hinge regions; other site 758793006684 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 758793006685 oligomerisation interface [polypeptide binding]; other site 758793006686 mobile loop; other site 758793006687 roof hairpin; other site 758793006688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793006689 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 758793006690 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793006691 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 758793006692 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 758793006693 BON domain; Region: BON; pfam04972 758793006694 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 758793006695 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 758793006696 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 758793006697 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 758793006698 putative catalytic residue [active] 758793006699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793006700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793006701 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 758793006702 putative substrate binding pocket [chemical binding]; other site 758793006703 putative dimerization interface [polypeptide binding]; other site 758793006704 Cupin; Region: Cupin_6; pfam12852 758793006705 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793006706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793006707 XdhC Rossmann domain; Region: XdhC_C; pfam13478 758793006708 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 758793006709 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793006710 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793006711 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 758793006712 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 758793006713 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793006714 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 758793006715 major facilitator superfamily transporter; Provisional; Region: PRK05122 758793006716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793006717 putative substrate translocation pore; other site 758793006718 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758793006719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793006720 DNA-binding site [nucleotide binding]; DNA binding site 758793006721 UTRA domain; Region: UTRA; pfam07702 758793006722 putative transporter; Provisional; Region: PRK10504 758793006723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793006724 putative substrate translocation pore; other site 758793006725 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793006726 hypothetical protein; Validated; Region: PRK08238 758793006727 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 758793006728 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 758793006729 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 758793006730 superoxide dismutase; Provisional; Region: PRK10543 758793006731 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 758793006732 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 758793006733 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 758793006734 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 758793006735 generic binding surface II; other site 758793006736 generic binding surface I; other site 758793006737 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 758793006738 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 758793006739 Uncharacterized conserved protein [Function unknown]; Region: COG2835 758793006740 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 758793006741 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 758793006742 Ligand binding site; other site 758793006743 oligomer interface; other site 758793006744 adenylate kinase; Reviewed; Region: adk; PRK00279 758793006745 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 758793006746 AMP-binding site [chemical binding]; other site 758793006747 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 758793006748 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 758793006749 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 758793006750 NAD binding site [chemical binding]; other site 758793006751 homodimer interface [polypeptide binding]; other site 758793006752 homotetramer interface [polypeptide binding]; other site 758793006753 active site 758793006754 Uncharacterized conserved protein [Function unknown]; Region: COG2912 758793006755 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 758793006756 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 758793006757 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 758793006758 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 758793006759 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 758793006760 ornithine carbamoyltransferase; Provisional; Region: PRK00779 758793006761 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 758793006762 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 758793006763 argininosuccinate synthase; Provisional; Region: PRK13820 758793006764 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 758793006765 ANP binding site [chemical binding]; other site 758793006766 Substrate Binding Site II [chemical binding]; other site 758793006767 Substrate Binding Site I [chemical binding]; other site 758793006768 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 758793006769 FAD binding domain; Region: FAD_binding_4; pfam01565 758793006770 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 758793006771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 758793006772 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 758793006773 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 758793006774 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 758793006775 putative deacylase active site [active] 758793006776 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 758793006777 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 758793006778 active site 758793006779 Int/Topo IB signature motif; other site 758793006780 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 758793006781 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 758793006782 DNA binding site [nucleotide binding] 758793006783 active site 758793006784 epoxyqueuosine reductase; Region: TIGR00276 758793006785 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 758793006786 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 758793006787 AMIN domain; Region: AMIN; pfam11741 758793006788 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 758793006789 active site 758793006790 metal binding site [ion binding]; metal-binding site 758793006791 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 758793006792 Pirin-related protein [General function prediction only]; Region: COG1741 758793006793 Pirin; Region: Pirin; pfam02678 758793006794 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 758793006795 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 758793006796 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758793006797 catalytic residues [active] 758793006798 hypothetical protein; Provisional; Region: PRK08328 758793006799 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 758793006800 putative ATP binding site [chemical binding]; other site 758793006801 putative substrate interface [chemical binding]; other site 758793006802 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 758793006803 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 758793006804 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 758793006805 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 758793006806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793006807 S-adenosylmethionine binding site [chemical binding]; other site 758793006808 Protein of unknown function DUF72; Region: DUF72; pfam01904 758793006809 methionine sulfoxide reductase A; Provisional; Region: PRK14054 758793006810 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 758793006811 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793006812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793006813 putative DNA binding site [nucleotide binding]; other site 758793006814 putative Zn2+ binding site [ion binding]; other site 758793006815 AsnC family; Region: AsnC_trans_reg; pfam01037 758793006816 Putative cyclase; Region: Cyclase; cl00814 758793006817 kynureninase; Region: kynureninase; TIGR01814 758793006818 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 758793006819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793006820 catalytic residue [active] 758793006821 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 758793006822 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793006823 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793006824 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793006825 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 758793006826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793006827 FAD binding site [chemical binding]; other site 758793006828 substrate binding pocket [chemical binding]; other site 758793006829 catalytic base [active] 758793006830 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 758793006831 Predicted membrane protein [Function unknown]; Region: COG5393 758793006832 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 758793006833 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 758793006834 PilX N-terminal; Region: PilX_N; pfam14341 758793006835 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 758793006836 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 758793006837 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 758793006838 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 758793006839 ATP cone domain; Region: ATP-cone; pfam03477 758793006840 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 758793006841 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 758793006842 dimer interface [polypeptide binding]; other site 758793006843 active site 758793006844 glycine-pyridoxal phosphate binding site [chemical binding]; other site 758793006845 folate binding site [chemical binding]; other site 758793006846 malonic semialdehyde reductase; Provisional; Region: PRK10538 758793006847 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 758793006848 putative NAD(P) binding site [chemical binding]; other site 758793006849 homodimer interface [polypeptide binding]; other site 758793006850 homotetramer interface [polypeptide binding]; other site 758793006851 active site 758793006852 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758793006853 active site 758793006854 TolQ protein; Region: tolQ; TIGR02796 758793006855 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 758793006856 TolR protein; Region: tolR; TIGR02801 758793006857 TolA protein; Region: tolA_full; TIGR02794 758793006858 TonB C terminal; Region: TonB_2; pfam13103 758793006859 translocation protein TolB; Provisional; Region: tolB; PRK02889 758793006860 TolB amino-terminal domain; Region: TolB_N; pfam04052 758793006861 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 758793006862 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 758793006863 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 758793006864 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 758793006865 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 758793006866 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793006867 ligand binding site [chemical binding]; other site 758793006868 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 758793006869 Tetratricopeptide repeat; Region: TPR_6; pfam13174 758793006870 WYL domain; Region: WYL; pfam13280 758793006871 AAA domain; Region: AAA_23; pfam13476 758793006872 P-loop containing region of AAA domain; Region: AAA_29; cl17516 758793006873 AAA domain; Region: AAA_27; pfam13514 758793006874 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 758793006875 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758793006876 active site 758793006877 metal binding site [ion binding]; metal-binding site 758793006878 DNA binding site [nucleotide binding] 758793006879 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 758793006880 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 758793006881 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 758793006882 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 758793006883 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 758793006884 SurA N-terminal domain; Region: SurA_N; pfam09312 758793006885 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 758793006886 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 758793006887 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 758793006888 Organic solvent tolerance protein; Region: OstA_C; pfam04453 758793006889 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 758793006890 Phosphotransferase enzyme family; Region: APH; pfam01636 758793006891 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 758793006892 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 758793006893 Substrate binding site; other site 758793006894 metal-binding site 758793006895 adenylosuccinate lyase; Provisional; Region: PRK09285 758793006896 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 758793006897 tetramer interface [polypeptide binding]; other site 758793006898 active site 758793006899 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 758793006900 AAA domain; Region: AAA_33; pfam13671 758793006901 ATP-binding site [chemical binding]; other site 758793006902 Gluconate-6-phosphate binding site [chemical binding]; other site 758793006903 fructuronate transporter; Provisional; Region: PRK10034; cl15264 758793006904 GntP family permease; Region: GntP_permease; pfam02447 758793006905 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 758793006906 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 758793006907 active site 758793006908 intersubunit interface [polypeptide binding]; other site 758793006909 catalytic residue [active] 758793006910 phosphogluconate dehydratase; Validated; Region: PRK09054 758793006911 6-phosphogluconate dehydratase; Region: edd; TIGR01196 758793006912 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758793006913 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758793006914 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758793006915 putative active site [active] 758793006916 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 758793006917 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 758793006918 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 758793006919 putative catalytic cysteine [active] 758793006920 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 758793006921 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 758793006922 Lipopolysaccharide-assembly; Region: LptE; cl01125 758793006923 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 758793006924 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 758793006925 HIGH motif; other site 758793006926 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 758793006927 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 758793006928 active site 758793006929 KMSKS motif; other site 758793006930 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 758793006931 tRNA binding surface [nucleotide binding]; other site 758793006932 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 758793006933 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 758793006934 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 758793006935 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 758793006936 dihydrodipicolinate reductase; Provisional; Region: PRK00048 758793006937 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 758793006938 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 758793006939 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 758793006940 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 758793006941 ferric uptake regulator; Provisional; Region: fur; PRK09462 758793006942 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 758793006943 metal binding site 2 [ion binding]; metal-binding site 758793006944 putative DNA binding helix; other site 758793006945 metal binding site 1 [ion binding]; metal-binding site 758793006946 dimer interface [polypeptide binding]; other site 758793006947 structural Zn2+ binding site [ion binding]; other site 758793006948 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 758793006949 ureidoglycolate hydrolase; Provisional; Region: PRK03606 758793006950 allantoicase; Provisional; Region: PRK13257 758793006951 Allantoicase repeat; Region: Allantoicase; pfam03561 758793006952 Allantoicase repeat; Region: Allantoicase; pfam03561 758793006953 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 758793006954 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758793006955 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793006956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793006957 DNA-binding site [nucleotide binding]; DNA binding site 758793006958 FCD domain; Region: FCD; pfam07729 758793006959 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 758793006960 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 758793006961 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 758793006962 transketolase; Reviewed; Region: PRK12753 758793006963 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 758793006964 TPP-binding site [chemical binding]; other site 758793006965 dimer interface [polypeptide binding]; other site 758793006966 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758793006967 PYR/PP interface [polypeptide binding]; other site 758793006968 dimer interface [polypeptide binding]; other site 758793006969 TPP binding site [chemical binding]; other site 758793006970 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793006971 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 758793006972 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793006973 putative dimer interface [polypeptide binding]; other site 758793006974 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 758793006975 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 758793006976 putative RNAase interaction site [polypeptide binding]; other site 758793006977 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 758793006978 active site 758793006979 barstar interaction site; other site 758793006980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006981 TPR motif; other site 758793006982 TPR repeat; Region: TPR_11; pfam13414 758793006983 TPR repeat; Region: TPR_11; pfam13414 758793006984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006985 binding surface 758793006986 TPR motif; other site 758793006987 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 758793006988 Haemagglutinin; Region: HIM; pfam05662 758793006989 TPR repeat; Region: TPR_11; pfam13414 758793006990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006991 TPR motif; other site 758793006992 binding surface 758793006993 TPR repeat; Region: TPR_11; pfam13414 758793006994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006995 TPR motif; other site 758793006996 binding surface 758793006997 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 758793006998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793006999 TPR motif; other site 758793007000 binding surface 758793007001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793007002 binding surface 758793007003 TPR motif; other site 758793007004 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 758793007005 malic enzyme; Reviewed; Region: PRK12862 758793007006 Malic enzyme, N-terminal domain; Region: malic; pfam00390 758793007007 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 758793007008 putative NAD(P) binding site [chemical binding]; other site 758793007009 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 758793007010 thiamine monophosphate kinase; Provisional; Region: PRK05731 758793007011 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 758793007012 ATP binding site [chemical binding]; other site 758793007013 dimerization interface [polypeptide binding]; other site 758793007014 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 758793007015 tetramer interfaces [polypeptide binding]; other site 758793007016 binuclear metal-binding site [ion binding]; other site 758793007017 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 758793007018 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 758793007019 active site 758793007020 dimer interface [polypeptide binding]; other site 758793007021 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 758793007022 active site 758793007023 catalytic residues [active] 758793007024 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 758793007025 short chain dehydrogenase; Provisional; Region: PRK12939 758793007026 classical (c) SDRs; Region: SDR_c; cd05233 758793007027 NAD(P) binding site [chemical binding]; other site 758793007028 active site 758793007029 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793007030 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793007031 TM-ABC transporter signature motif; other site 758793007032 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 758793007033 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793007034 Walker A/P-loop; other site 758793007035 ATP binding site [chemical binding]; other site 758793007036 Q-loop/lid; other site 758793007037 ABC transporter signature motif; other site 758793007038 Walker B; other site 758793007039 D-loop; other site 758793007040 H-loop/switch region; other site 758793007041 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793007042 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 758793007043 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 758793007044 ligand binding site [chemical binding]; other site 758793007045 short chain dehydrogenase; Provisional; Region: PRK07063 758793007046 classical (c) SDRs; Region: SDR_c; cd05233 758793007047 NAD(P) binding site [chemical binding]; other site 758793007048 active site 758793007049 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 758793007050 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 758793007051 active site 758793007052 intersubunit interface [polypeptide binding]; other site 758793007053 catalytic residue [active] 758793007054 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 758793007055 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 758793007056 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793007057 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793007058 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793007059 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 758793007060 Transglycosylase; Region: Transgly; cl17702 758793007061 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 758793007062 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 758793007063 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 758793007064 shikimate binding site; other site 758793007065 NAD(P) binding site [chemical binding]; other site 758793007066 Exoribonuclease R [Transcription]; Region: VacB; COG0557 758793007067 RNB domain; Region: RNB; pfam00773 758793007068 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 758793007069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793007070 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 758793007071 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 758793007072 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758793007073 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758793007074 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 758793007075 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793007076 catalytic residues [active] 758793007077 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 758793007078 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 758793007079 carboxyltransferase (CT) interaction site; other site 758793007080 biotinylation site [posttranslational modification]; other site 758793007081 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 758793007082 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758793007083 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793007084 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 758793007085 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 758793007086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793007087 S-adenosylmethionine binding site [chemical binding]; other site 758793007088 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 758793007089 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 758793007090 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 758793007091 dimer interface [polypeptide binding]; other site 758793007092 catalytic triad [active] 758793007093 peroxidatic and resolving cysteines [active] 758793007094 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 758793007095 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793007096 substrate binding site [chemical binding]; other site 758793007097 ATP binding site [chemical binding]; other site 758793007098 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 758793007099 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 758793007100 dimer interface [polypeptide binding]; other site 758793007101 putative radical transfer pathway; other site 758793007102 diiron center [ion binding]; other site 758793007103 tyrosyl radical; other site 758793007104 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 758793007105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007106 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793007107 putative substrate translocation pore; other site 758793007108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007109 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 758793007110 ATP cone domain; Region: ATP-cone; pfam03477 758793007111 Class I ribonucleotide reductase; Region: RNR_I; cd01679 758793007112 active site 758793007113 dimer interface [polypeptide binding]; other site 758793007114 catalytic residues [active] 758793007115 effector binding site; other site 758793007116 R2 peptide binding site; other site 758793007117 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 758793007118 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 758793007119 amidase catalytic site [active] 758793007120 Zn binding residues [ion binding]; other site 758793007121 substrate binding site [chemical binding]; other site 758793007122 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 758793007123 signal recognition particle protein; Provisional; Region: PRK10867 758793007124 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 758793007125 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 758793007126 GTP binding site [chemical binding]; other site 758793007127 Signal peptide binding domain; Region: SRP_SPB; pfam02978 758793007128 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793007129 active site 758793007130 MarC family integral membrane protein; Region: MarC; cl00919 758793007131 prolyl-tRNA synthetase; Provisional; Region: PRK09194 758793007132 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 758793007133 dimer interface [polypeptide binding]; other site 758793007134 motif 1; other site 758793007135 active site 758793007136 motif 2; other site 758793007137 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 758793007138 putative deacylase active site [active] 758793007139 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 758793007140 active site 758793007141 motif 3; other site 758793007142 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 758793007143 anticodon binding site; other site 758793007144 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 758793007145 putative active site [active] 758793007146 Ap4A binding site [chemical binding]; other site 758793007147 nudix motif; other site 758793007148 putative metal binding site [ion binding]; other site 758793007149 CNP1-like family; Region: CNP1; pfam08750 758793007150 gamma-glutamyl kinase; Provisional; Region: PRK05429 758793007151 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 758793007152 nucleotide binding site [chemical binding]; other site 758793007153 homotetrameric interface [polypeptide binding]; other site 758793007154 putative phosphate binding site [ion binding]; other site 758793007155 putative allosteric binding site; other site 758793007156 PUA domain; Region: PUA; pfam01472 758793007157 GTPase CgtA; Reviewed; Region: obgE; PRK12299 758793007158 GTP1/OBG; Region: GTP1_OBG; pfam01018 758793007159 Obg GTPase; Region: Obg; cd01898 758793007160 G1 box; other site 758793007161 GTP/Mg2+ binding site [chemical binding]; other site 758793007162 Switch I region; other site 758793007163 G2 box; other site 758793007164 G3 box; other site 758793007165 Switch II region; other site 758793007166 G4 box; other site 758793007167 G5 box; other site 758793007168 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 758793007169 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 758793007170 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 758793007171 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 758793007172 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 758793007173 substrate binding pocket [chemical binding]; other site 758793007174 chain length determination region; other site 758793007175 substrate-Mg2+ binding site; other site 758793007176 catalytic residues [active] 758793007177 aspartate-rich region 1; other site 758793007178 active site lid residues [active] 758793007179 aspartate-rich region 2; other site 758793007180 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 758793007181 Domain of unknown function DUF21; Region: DUF21; pfam01595 758793007182 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 758793007183 Transporter associated domain; Region: CorC_HlyC; smart01091 758793007184 Type II/IV secretion system protein; Region: T2SE; pfam00437 758793007185 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 758793007186 Walker A motif; other site 758793007187 ATP binding site [chemical binding]; other site 758793007188 Walker B motif; other site 758793007189 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 758793007190 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758793007191 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 758793007192 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 758793007193 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 758793007194 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 758793007195 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 758793007196 CoA-binding site [chemical binding]; other site 758793007197 ATP-binding [chemical binding]; other site 758793007198 hypothetical protein; Provisional; Region: PRK05287 758793007199 Domain of unknown function (DUF329); Region: DUF329; pfam03884 758793007200 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 758793007201 active site 758793007202 8-oxo-dGMP binding site [chemical binding]; other site 758793007203 nudix motif; other site 758793007204 metal binding site [ion binding]; metal-binding site 758793007205 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 758793007206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793007207 Walker A motif; other site 758793007208 ATP binding site [chemical binding]; other site 758793007209 Walker B motif; other site 758793007210 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 758793007211 heterotetramer interface [polypeptide binding]; other site 758793007212 active site pocket [active] 758793007213 cleavage site 758793007214 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 758793007215 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 758793007216 SEC-C motif; Region: SEC-C; pfam02810 758793007217 Protein of unknown function (DUF721); Region: DUF721; pfam05258 758793007218 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 758793007219 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 758793007220 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 758793007221 catalytic triad [active] 758793007222 dimer interface [polypeptide binding]; other site 758793007223 cell division protein FtsZ; Validated; Region: PRK09330 758793007224 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 758793007225 nucleotide binding site [chemical binding]; other site 758793007226 SulA interaction site; other site 758793007227 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 758793007228 cell division protein FtsA; Region: ftsA; TIGR01174 758793007229 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758793007230 nucleotide binding site [chemical binding]; other site 758793007231 Cell division protein FtsA; Region: FtsA; pfam14450 758793007232 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 758793007233 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 758793007234 Cell division protein FtsQ; Region: FtsQ; pfam03799 758793007235 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 758793007236 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 758793007237 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793007238 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 758793007239 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 758793007240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758793007241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758793007242 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 758793007243 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 758793007244 active site 758793007245 homodimer interface [polypeptide binding]; other site 758793007246 cell division protein FtsW; Region: ftsW; TIGR02614 758793007247 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 758793007248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758793007249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758793007250 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 758793007251 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 758793007252 Mg++ binding site [ion binding]; other site 758793007253 putative catalytic motif [active] 758793007254 putative substrate binding site [chemical binding]; other site 758793007255 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 758793007256 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 758793007257 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758793007258 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758793007259 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 758793007260 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758793007261 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758793007262 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 758793007263 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 758793007264 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 758793007265 Cell division protein FtsL; Region: FtsL; cl11433 758793007266 MraW methylase family; Region: Methyltransf_5; cl17771 758793007267 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 758793007268 cell division protein MraZ; Reviewed; Region: PRK00326 758793007269 MraZ protein; Region: MraZ; pfam02381 758793007270 MraZ protein; Region: MraZ; pfam02381 758793007271 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 758793007272 diiron binding motif [ion binding]; other site 758793007273 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793007274 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793007275 trimer interface [polypeptide binding]; other site 758793007276 eyelet of channel; other site 758793007277 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 758793007278 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 758793007279 acyl-activating enzyme (AAE) consensus motif; other site 758793007280 putative AMP binding site [chemical binding]; other site 758793007281 putative active site [active] 758793007282 putative CoA binding site [chemical binding]; other site 758793007283 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 758793007284 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 758793007285 putative molybdopterin cofactor binding site [chemical binding]; other site 758793007286 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 758793007287 putative molybdopterin cofactor binding site; other site 758793007288 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 758793007289 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 758793007290 metal binding site [ion binding]; metal-binding site 758793007291 putative dimer interface [polypeptide binding]; other site 758793007292 enoyl-CoA hydratase; Provisional; Region: PRK05862 758793007293 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793007294 substrate binding site [chemical binding]; other site 758793007295 oxyanion hole (OAH) forming residues; other site 758793007296 trimer interface [polypeptide binding]; other site 758793007297 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 758793007298 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793007299 NAD(P) binding site [chemical binding]; other site 758793007300 catalytic residues [active] 758793007301 enoyl-CoA hydratase; Provisional; Region: PRK08140 758793007302 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793007303 substrate binding site [chemical binding]; other site 758793007304 oxyanion hole (OAH) forming residues; other site 758793007305 trimer interface [polypeptide binding]; other site 758793007306 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 758793007307 CoenzymeA binding site [chemical binding]; other site 758793007308 subunit interaction site [polypeptide binding]; other site 758793007309 PHB binding site; other site 758793007310 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 758793007311 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 758793007312 active site 758793007313 AMP binding site [chemical binding]; other site 758793007314 homodimer interface [polypeptide binding]; other site 758793007315 acyl-activating enzyme (AAE) consensus motif; other site 758793007316 CoA binding site [chemical binding]; other site 758793007317 MltA specific insert domain; Region: MltA; smart00925 758793007318 3D domain; Region: 3D; pfam06725 758793007319 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 758793007320 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 758793007321 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 758793007322 substrate binding site [chemical binding]; other site 758793007323 hexamer interface [polypeptide binding]; other site 758793007324 metal binding site [ion binding]; metal-binding site 758793007325 phosphoglycolate phosphatase; Provisional; Region: PRK13222 758793007326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793007327 motif II; other site 758793007328 anthranilate synthase component I; Provisional; Region: PRK13565 758793007329 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 758793007330 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 758793007331 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 758793007332 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 758793007333 glutamine binding [chemical binding]; other site 758793007334 catalytic triad [active] 758793007335 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 758793007336 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 758793007337 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 758793007338 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 758793007339 active site 758793007340 ribulose/triose binding site [chemical binding]; other site 758793007341 phosphate binding site [ion binding]; other site 758793007342 substrate (anthranilate) binding pocket [chemical binding]; other site 758793007343 product (indole) binding pocket [chemical binding]; other site 758793007344 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 758793007345 putative active site; other site 758793007346 putative metal binding residues [ion binding]; other site 758793007347 signature motif; other site 758793007348 putative triphosphate binding site [ion binding]; other site 758793007349 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 758793007350 ligand binding site [chemical binding]; other site 758793007351 active site 758793007352 UGI interface [polypeptide binding]; other site 758793007353 catalytic site [active] 758793007354 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758793007355 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793007356 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 758793007357 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 758793007358 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 758793007359 protein binding site [polypeptide binding]; other site 758793007360 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 758793007361 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 758793007362 dimerization domain [polypeptide binding]; other site 758793007363 dimer interface [polypeptide binding]; other site 758793007364 catalytic residues [active] 758793007365 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 758793007366 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 758793007367 GTP-binding protein YchF; Reviewed; Region: PRK09601 758793007368 YchF GTPase; Region: YchF; cd01900 758793007369 G1 box; other site 758793007370 GTP/Mg2+ binding site [chemical binding]; other site 758793007371 Switch I region; other site 758793007372 G2 box; other site 758793007373 Switch II region; other site 758793007374 G3 box; other site 758793007375 G4 box; other site 758793007376 G5 box; other site 758793007377 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 758793007378 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 758793007379 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 758793007380 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793007381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793007382 ABC transporter; Region: ABC_tran_2; pfam12848 758793007383 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 758793007384 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 758793007385 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 758793007386 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 758793007387 Isochorismatase family; Region: Isochorismatase; pfam00857 758793007388 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 758793007389 catalytic triad [active] 758793007390 conserved cis-peptide bond; other site 758793007391 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 758793007392 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 758793007393 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 758793007394 active site 758793007395 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 758793007396 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 758793007397 tRNA; other site 758793007398 putative tRNA binding site [nucleotide binding]; other site 758793007399 putative NADP binding site [chemical binding]; other site 758793007400 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 758793007401 peptide chain release factor 1; Validated; Region: prfA; PRK00591 758793007402 This domain is found in peptide chain release factors; Region: PCRF; smart00937 758793007403 RF-1 domain; Region: RF-1; pfam00472 758793007404 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 758793007405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793007406 S-adenosylmethionine binding site [chemical binding]; other site 758793007407 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 758793007408 putative GSH binding site [chemical binding]; other site 758793007409 catalytic residues [active] 758793007410 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 758793007411 Flavoprotein; Region: Flavoprotein; pfam02441 758793007412 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 758793007413 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 758793007414 putative active site [active] 758793007415 metal binding site [ion binding]; metal-binding site 758793007416 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 758793007417 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 758793007418 DNA-binding site [nucleotide binding]; DNA binding site 758793007419 RNA-binding motif; other site 758793007420 putative chaperone; Provisional; Region: PRK11678 758793007421 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 758793007422 nucleotide binding site [chemical binding]; other site 758793007423 putative NEF/HSP70 interaction site [polypeptide binding]; other site 758793007424 SBD interface [polypeptide binding]; other site 758793007425 benzoate transport; Region: 2A0115; TIGR00895 758793007426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007427 putative substrate translocation pore; other site 758793007428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007429 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 758793007430 putative FMN binding site [chemical binding]; other site 758793007431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793007433 putative substrate translocation pore; other site 758793007434 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793007435 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793007436 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 758793007437 Methyltransferase domain; Region: Methyltransf_32; pfam13679 758793007438 Methyltransferase domain; Region: Methyltransf_31; pfam13847 758793007439 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793007440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793007441 DNA-binding site [nucleotide binding]; DNA binding site 758793007442 FCD domain; Region: FCD; pfam07729 758793007443 3-dehydroquinate synthase (EC 4.6.1.3); Region: DHQS; cl00640 758793007444 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 758793007445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007446 D-galactonate transporter; Region: 2A0114; TIGR00893 758793007447 putative substrate translocation pore; other site 758793007448 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 758793007449 galactarate dehydratase; Region: galactar-dH20; TIGR03248 758793007450 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 758793007451 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 758793007452 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793007453 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 758793007454 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793007455 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 758793007456 dimer interface [polypeptide binding]; other site 758793007457 N-terminal domain interface [polypeptide binding]; other site 758793007458 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 758793007459 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 758793007460 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 758793007461 Qi binding site; other site 758793007462 intrachain domain interface; other site 758793007463 interchain domain interface [polypeptide binding]; other site 758793007464 heme bH binding site [chemical binding]; other site 758793007465 heme bL binding site [chemical binding]; other site 758793007466 Qo binding site; other site 758793007467 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 758793007468 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 758793007469 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 758793007470 [2Fe-2S] cluster binding site [ion binding]; other site 758793007471 Uncharacterized conserved protein [Function unknown]; Region: COG0327 758793007472 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 758793007473 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 758793007474 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 758793007475 protein binding site [polypeptide binding]; other site 758793007476 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 758793007477 sec-independent translocase; Provisional; Region: tatB; PRK01919 758793007478 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 758793007479 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 758793007480 nucleotide binding site/active site [active] 758793007481 HIT family signature motif; other site 758793007482 catalytic residue [active] 758793007483 Predicted membrane protein [Function unknown]; Region: COG3671 758793007484 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 758793007485 metal binding site [ion binding]; metal-binding site 758793007486 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 758793007487 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 758793007488 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 758793007489 substrate binding site [chemical binding]; other site 758793007490 glutamase interaction surface [polypeptide binding]; other site 758793007491 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 758793007492 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 758793007493 catalytic residues [active] 758793007494 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 758793007495 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 758793007496 putative active site [active] 758793007497 oxyanion strand; other site 758793007498 catalytic triad [active] 758793007499 MarC family integral membrane protein; Region: MarC; cl00919 758793007500 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 758793007501 putative active site pocket [active] 758793007502 4-fold oligomerization interface [polypeptide binding]; other site 758793007503 metal binding residues [ion binding]; metal-binding site 758793007504 3-fold/trimer interface [polypeptide binding]; other site 758793007505 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 758793007506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793007507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793007508 homodimer interface [polypeptide binding]; other site 758793007509 catalytic residue [active] 758793007510 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 758793007511 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 758793007512 NAD binding site [chemical binding]; other site 758793007513 dimerization interface [polypeptide binding]; other site 758793007514 product binding site; other site 758793007515 substrate binding site [chemical binding]; other site 758793007516 zinc binding site [ion binding]; other site 758793007517 catalytic residues [active] 758793007518 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 758793007519 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 758793007520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 758793007521 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 758793007522 hinge; other site 758793007523 active site 758793007524 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 758793007525 ABC-2 type transporter; Region: ABC2_membrane; cl17235 758793007526 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758793007527 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758793007528 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758793007529 Walker A/P-loop; other site 758793007530 ATP binding site [chemical binding]; other site 758793007531 Q-loop/lid; other site 758793007532 ABC transporter signature motif; other site 758793007533 Walker B; other site 758793007534 D-loop; other site 758793007535 H-loop/switch region; other site 758793007536 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 758793007537 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 758793007538 VacJ like lipoprotein; Region: VacJ; cl01073 758793007539 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 758793007540 mce related protein; Region: MCE; pfam02470 758793007541 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 758793007542 Permease; Region: Permease; pfam02405 758793007543 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 758793007544 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 758793007545 Walker A/P-loop; other site 758793007546 ATP binding site [chemical binding]; other site 758793007547 Q-loop/lid; other site 758793007548 ABC transporter signature motif; other site 758793007549 Walker B; other site 758793007550 D-loop; other site 758793007551 H-loop/switch region; other site 758793007552 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 758793007553 thiamine phosphate binding site [chemical binding]; other site 758793007554 active site 758793007555 pyrophosphate binding site [ion binding]; other site 758793007556 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 758793007557 ThiS interaction site; other site 758793007558 putative active site [active] 758793007559 tetramer interface [polypeptide binding]; other site 758793007560 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 758793007561 thiS-thiF/thiG interaction site; other site 758793007562 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 758793007563 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 758793007564 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 758793007565 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 758793007566 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 758793007567 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793007568 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 758793007569 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 758793007570 active site 758793007571 dimer interface [polypeptide binding]; other site 758793007572 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 758793007573 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 758793007574 active site 758793007575 FMN binding site [chemical binding]; other site 758793007576 substrate binding site [chemical binding]; other site 758793007577 3Fe-4S cluster binding site [ion binding]; other site 758793007578 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 758793007579 domain interface; other site 758793007580 Transposase IS200 like; Region: Y1_Tnp; cl00848 758793007581 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 758793007582 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 758793007583 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 758793007584 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 758793007585 putative active site [active] 758793007586 catalytic site [active] 758793007587 putative metal binding site [ion binding]; other site 758793007588 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 758793007589 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 758793007590 Walker A/P-loop; other site 758793007591 ATP binding site [chemical binding]; other site 758793007592 Q-loop/lid; other site 758793007593 ABC transporter signature motif; other site 758793007594 Walker B; other site 758793007595 D-loop; other site 758793007596 H-loop/switch region; other site 758793007597 TOBE domain; Region: TOBE_2; pfam08402 758793007598 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 758793007599 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758793007600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793007601 dimer interface [polypeptide binding]; other site 758793007602 conserved gate region; other site 758793007603 putative PBP binding loops; other site 758793007604 ABC-ATPase subunit interface; other site 758793007605 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 758793007606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793007607 dimer interface [polypeptide binding]; other site 758793007608 conserved gate region; other site 758793007609 putative PBP binding loops; other site 758793007610 ABC-ATPase subunit interface; other site 758793007611 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 758793007612 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 758793007613 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 758793007614 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758793007615 Zn2+ binding site [ion binding]; other site 758793007616 Mg2+ binding site [ion binding]; other site 758793007617 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 758793007618 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 758793007619 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 758793007620 active site 758793007621 dimer interface [polypeptide binding]; other site 758793007622 metal binding site [ion binding]; metal-binding site 758793007623 shikimate kinase; Reviewed; Region: aroK; PRK00131 758793007624 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 758793007625 ADP binding site [chemical binding]; other site 758793007626 magnesium binding site [ion binding]; other site 758793007627 putative shikimate binding site; other site 758793007628 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 758793007629 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 758793007630 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 758793007631 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 758793007632 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 758793007633 Transglycosylase; Region: Transgly; pfam00912 758793007634 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 758793007635 frataxin-like protein; Provisional; Region: cyaY; PRK00446 758793007636 putative iron binding site [ion binding]; other site 758793007637 diaminopimelate decarboxylase; Region: lysA; TIGR01048 758793007638 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 758793007639 active site 758793007640 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758793007641 substrate binding site [chemical binding]; other site 758793007642 catalytic residues [active] 758793007643 dimer interface [polypeptide binding]; other site 758793007644 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 758793007645 TMAO/DMSO reductase; Reviewed; Region: PRK05363 758793007646 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 758793007647 Moco binding site; other site 758793007648 metal coordination site [ion binding]; other site 758793007649 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 758793007650 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 758793007651 ResB-like family; Region: ResB; pfam05140 758793007652 Cytochrome c553 [Energy production and conversion]; Region: COG2863 758793007653 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 758793007654 Cytochrome c; Region: Cytochrom_C; cl11414 758793007655 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 758793007656 G1 box; other site 758793007657 GTP/Mg2+ binding site [chemical binding]; other site 758793007658 Switch I region; other site 758793007659 G2 box; other site 758793007660 G3 box; other site 758793007661 Switch II region; other site 758793007662 G4 box; other site 758793007663 G5 box; other site 758793007664 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 758793007665 dimer interface [polypeptide binding]; other site 758793007666 active site 758793007667 aspartate-rich active site metal binding site; other site 758793007668 allosteric magnesium binding site [ion binding]; other site 758793007669 Schiff base residues; other site 758793007670 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 758793007671 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 758793007672 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 758793007673 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 758793007674 DsbD alpha interface [polypeptide binding]; other site 758793007675 catalytic residues [active] 758793007676 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 758793007677 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 758793007678 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 758793007679 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 758793007680 alphaNTD homodimer interface [polypeptide binding]; other site 758793007681 alphaNTD - beta interaction site [polypeptide binding]; other site 758793007682 alphaNTD - beta' interaction site [polypeptide binding]; other site 758793007683 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 758793007684 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 758793007685 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 758793007686 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 758793007687 RNA binding surface [nucleotide binding]; other site 758793007688 30S ribosomal protein S11; Validated; Region: PRK05309 758793007689 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 758793007690 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 758793007691 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 758793007692 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 758793007693 SecY translocase; Region: SecY; pfam00344 758793007694 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 758793007695 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 758793007696 23S rRNA binding site [nucleotide binding]; other site 758793007697 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 758793007698 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 758793007699 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 758793007700 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 758793007701 5S rRNA interface [nucleotide binding]; other site 758793007702 L27 interface [polypeptide binding]; other site 758793007703 23S rRNA interface [nucleotide binding]; other site 758793007704 L5 interface [polypeptide binding]; other site 758793007705 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 758793007706 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 758793007707 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 758793007708 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 758793007709 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 758793007710 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 758793007711 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 758793007712 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 758793007713 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 758793007714 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 758793007715 RNA binding site [nucleotide binding]; other site 758793007716 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 758793007717 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 758793007718 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 758793007719 23S rRNA interface [nucleotide binding]; other site 758793007720 putative translocon interaction site; other site 758793007721 signal recognition particle (SRP54) interaction site; other site 758793007722 L23 interface [polypeptide binding]; other site 758793007723 trigger factor interaction site; other site 758793007724 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 758793007725 23S rRNA interface [nucleotide binding]; other site 758793007726 5S rRNA interface [nucleotide binding]; other site 758793007727 putative antibiotic binding site [chemical binding]; other site 758793007728 L25 interface [polypeptide binding]; other site 758793007729 L27 interface [polypeptide binding]; other site 758793007730 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 758793007731 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 758793007732 G-X-X-G motif; other site 758793007733 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 758793007734 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 758793007735 putative translocon binding site; other site 758793007736 protein-rRNA interface [nucleotide binding]; other site 758793007737 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 758793007738 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 758793007739 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 758793007740 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 758793007741 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 758793007742 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 758793007743 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 758793007744 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 758793007745 elongation factor Tu; Reviewed; Region: PRK00049 758793007746 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 758793007747 G1 box; other site 758793007748 GEF interaction site [polypeptide binding]; other site 758793007749 GTP/Mg2+ binding site [chemical binding]; other site 758793007750 Switch I region; other site 758793007751 G2 box; other site 758793007752 G3 box; other site 758793007753 Switch II region; other site 758793007754 G4 box; other site 758793007755 G5 box; other site 758793007756 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 758793007757 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 758793007758 Antibiotic Binding Site [chemical binding]; other site 758793007759 elongation factor G; Reviewed; Region: PRK00007 758793007760 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 758793007761 G1 box; other site 758793007762 putative GEF interaction site [polypeptide binding]; other site 758793007763 GTP/Mg2+ binding site [chemical binding]; other site 758793007764 Switch I region; other site 758793007765 G2 box; other site 758793007766 G3 box; other site 758793007767 Switch II region; other site 758793007768 G4 box; other site 758793007769 G5 box; other site 758793007770 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 758793007771 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 758793007772 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 758793007773 30S ribosomal protein S7; Validated; Region: PRK05302 758793007774 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 758793007775 streptomycin interaction site [chemical binding]; other site 758793007776 23S rRNA interaction site [nucleotide binding]; other site 758793007777 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 758793007778 16S rRNA interaction site [nucleotide binding]; other site 758793007779 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 758793007780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793007781 ATP binding site [chemical binding]; other site 758793007782 putative Mg++ binding site [ion binding]; other site 758793007783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793007784 nucleotide binding region [chemical binding]; other site 758793007785 ATP-binding site [chemical binding]; other site 758793007786 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 758793007787 HRDC domain; Region: HRDC; pfam00570 758793007788 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 758793007789 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 758793007790 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 758793007791 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 758793007792 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 758793007793 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 758793007794 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 758793007795 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 758793007796 DNA binding site [nucleotide binding] 758793007797 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 758793007798 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 758793007799 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 758793007800 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 758793007801 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 758793007802 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 758793007803 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 758793007804 RPB3 interaction site [polypeptide binding]; other site 758793007805 RPB1 interaction site [polypeptide binding]; other site 758793007806 RPB11 interaction site [polypeptide binding]; other site 758793007807 RPB10 interaction site [polypeptide binding]; other site 758793007808 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 758793007809 peripheral dimer interface [polypeptide binding]; other site 758793007810 core dimer interface [polypeptide binding]; other site 758793007811 L10 interface [polypeptide binding]; other site 758793007812 L11 interface [polypeptide binding]; other site 758793007813 putative EF-Tu interaction site [polypeptide binding]; other site 758793007814 putative EF-G interaction site [polypeptide binding]; other site 758793007815 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 758793007816 23S rRNA interface [nucleotide binding]; other site 758793007817 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 758793007818 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 758793007819 mRNA/rRNA interface [nucleotide binding]; other site 758793007820 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 758793007821 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 758793007822 23S rRNA interface [nucleotide binding]; other site 758793007823 L7/L12 interface [polypeptide binding]; other site 758793007824 putative thiostrepton binding site; other site 758793007825 L25 interface [polypeptide binding]; other site 758793007826 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 758793007827 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 758793007828 putative homodimer interface [polypeptide binding]; other site 758793007829 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 758793007830 heterodimer interface [polypeptide binding]; other site 758793007831 homodimer interface [polypeptide binding]; other site 758793007832 elongation factor Tu; Reviewed; Region: PRK00049 758793007833 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 758793007834 G1 box; other site 758793007835 GEF interaction site [polypeptide binding]; other site 758793007836 GTP/Mg2+ binding site [chemical binding]; other site 758793007837 Switch I region; other site 758793007838 G2 box; other site 758793007839 G3 box; other site 758793007840 Switch II region; other site 758793007841 G4 box; other site 758793007842 G5 box; other site 758793007843 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 758793007844 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 758793007845 Antibiotic Binding Site [chemical binding]; other site 758793007846 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 758793007847 active site 758793007848 catalytic triad [active] 758793007849 oxyanion hole [active] 758793007850 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 758793007851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793007852 S-adenosylmethionine binding site [chemical binding]; other site 758793007853 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 758793007854 benzoate transport; Region: 2A0115; TIGR00895 758793007855 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 758793007856 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 758793007857 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 758793007858 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 758793007859 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 758793007860 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 758793007861 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 758793007862 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 758793007863 FAD binding pocket [chemical binding]; other site 758793007864 FAD binding motif [chemical binding]; other site 758793007865 phosphate binding motif [ion binding]; other site 758793007866 beta-alpha-beta structure motif; other site 758793007867 NAD(p) ribose binding residues [chemical binding]; other site 758793007868 NAD binding pocket [chemical binding]; other site 758793007869 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 758793007870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793007871 catalytic loop [active] 758793007872 iron binding site [ion binding]; other site 758793007873 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 758793007874 Protein of unknown function; Region: DUF3658; pfam12395 758793007875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793007876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793007877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 758793007878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793007879 Coenzyme A binding pocket [chemical binding]; other site 758793007880 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793007881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793007882 putative DNA binding site [nucleotide binding]; other site 758793007883 putative Zn2+ binding site [ion binding]; other site 758793007884 AsnC family; Region: AsnC_trans_reg; pfam01037 758793007885 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 758793007886 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 758793007887 dimer interface [polypeptide binding]; other site 758793007888 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 758793007889 active site 758793007890 Fe binding site [ion binding]; other site 758793007891 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 758793007892 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 758793007893 dimer interface [polypeptide binding]; other site 758793007894 PYR/PP interface [polypeptide binding]; other site 758793007895 TPP binding site [chemical binding]; other site 758793007896 substrate binding site [chemical binding]; other site 758793007897 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 758793007898 TPP-binding site; other site 758793007899 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 758793007900 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 758793007901 Malic enzyme, N-terminal domain; Region: malic; pfam00390 758793007902 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 758793007903 putative NAD(P) binding site [chemical binding]; other site 758793007904 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 758793007905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793007906 active site 758793007907 transcriptional regulator RcsB; Provisional; Region: PRK10840 758793007908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793007909 active site 758793007910 phosphorylation site [posttranslational modification] 758793007911 intermolecular recognition site; other site 758793007912 dimerization interface [polypeptide binding]; other site 758793007913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793007914 DNA binding residues [nucleotide binding] 758793007915 dimerization interface [polypeptide binding]; other site 758793007916 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 758793007917 substrate binding site [chemical binding]; other site 758793007918 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 758793007919 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793007920 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 758793007921 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 758793007922 Response regulator receiver domain; Region: Response_reg; pfam00072 758793007923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793007924 active site 758793007925 phosphorylation site [posttranslational modification] 758793007926 intermolecular recognition site; other site 758793007927 dimerization interface [polypeptide binding]; other site 758793007928 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793007929 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 758793007930 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793007931 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 758793007932 Uncharacterized conserved protein [Function unknown]; Region: COG1656 758793007933 Protein of unknown function DUF82; Region: DUF82; pfam01927 758793007934 Cupin domain; Region: Cupin_2; cl17218 758793007935 citrate-proton symporter; Provisional; Region: PRK15075 758793007936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007937 putative substrate translocation pore; other site 758793007938 High potential iron-sulfur protein; Region: HIPIP; pfam01355 758793007939 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793007940 Predicted dehydrogenase [General function prediction only]; Region: COG0579 758793007941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793007942 ATP binding site [chemical binding]; other site 758793007943 Walker A motif; other site 758793007944 Walker B motif; other site 758793007945 arginine finger; other site 758793007946 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 758793007947 putative phosphate binding site [ion binding]; other site 758793007948 putative catalytic site [active] 758793007949 putative phosphate binding site [ion binding]; other site 758793007950 putative metal binding site [ion binding]; other site 758793007951 Response regulator receiver domain; Region: Response_reg; pfam00072 758793007952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793007953 active site 758793007954 phosphorylation site [posttranslational modification] 758793007955 intermolecular recognition site; other site 758793007956 dimerization interface [polypeptide binding]; other site 758793007957 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 758793007958 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758793007959 homotrimer interaction site [polypeptide binding]; other site 758793007960 putative active site [active] 758793007961 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 758793007962 MgtC family; Region: MgtC; pfam02308 758793007963 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 758793007964 ArsC family; Region: ArsC; pfam03960 758793007965 catalytic residues [active] 758793007966 Cupin domain; Region: Cupin_2; cl17218 758793007967 Protein of unknown function DUF72; Region: DUF72; pfam01904 758793007968 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 758793007969 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 758793007970 active site 758793007971 tetramer interface [polypeptide binding]; other site 758793007972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793007973 D-galactonate transporter; Region: 2A0114; TIGR00893 758793007974 putative substrate translocation pore; other site 758793007975 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793007976 tartronate semialdehyde reductase; Provisional; Region: PRK15059 758793007977 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 758793007978 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793007979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793007980 DNA-binding site [nucleotide binding]; DNA binding site 758793007981 FCD domain; Region: FCD; pfam07729 758793007982 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 758793007983 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 758793007984 glutaminase active site [active] 758793007985 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 758793007986 dimer interface [polypeptide binding]; other site 758793007987 active site 758793007988 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 758793007989 dimer interface [polypeptide binding]; other site 758793007990 active site 758793007991 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 758793007992 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 758793007993 Substrate binding site; other site 758793007994 Mg++ binding site; other site 758793007995 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 758793007996 active site 758793007997 substrate binding site [chemical binding]; other site 758793007998 CoA binding site [chemical binding]; other site 758793007999 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 758793008000 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 758793008001 Ligand Binding Site [chemical binding]; other site 758793008002 Dihydroneopterin aldolase; Region: FolB; smart00905 758793008003 active site 758793008004 short chain dehydrogenase; Provisional; Region: PRK09134 758793008005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793008006 NAD(P) binding site [chemical binding]; other site 758793008007 active site 758793008008 Uncharacterized conserved protein [Function unknown]; Region: COG1565 758793008009 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 758793008010 TPR repeat; Region: TPR_11; pfam13414 758793008011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 758793008012 binding surface 758793008013 TPR motif; other site 758793008014 TPR repeat; Region: TPR_11; pfam13414 758793008015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793008016 binding surface 758793008017 TPR motif; other site 758793008018 TPR repeat; Region: TPR_11; pfam13414 758793008019 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793008020 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 758793008021 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 758793008022 active site 758793008023 NTP binding site [chemical binding]; other site 758793008024 metal binding triad [ion binding]; metal-binding site 758793008025 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 758793008026 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 758793008027 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793008028 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 758793008029 putative C-terminal domain interface [polypeptide binding]; other site 758793008030 putative GSH binding site (G-site) [chemical binding]; other site 758793008031 putative dimer interface [polypeptide binding]; other site 758793008032 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 758793008033 putative substrate binding pocket (H-site) [chemical binding]; other site 758793008034 putative N-terminal domain interface [polypeptide binding]; other site 758793008035 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 758793008036 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 758793008037 putative NAD(P) binding site [chemical binding]; other site 758793008038 active site 758793008039 lytic murein transglycosylase; Provisional; Region: PRK11619 758793008040 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793008041 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793008042 catalytic residue [active] 758793008043 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 758793008044 MarR family; Region: MarR_2; cl17246 758793008045 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 758793008046 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 758793008047 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 758793008048 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 758793008049 putative active site [active] 758793008050 Protein of unknown function (DUF969); Region: DUF969; pfam06149 758793008051 Predicted membrane protein [Function unknown]; Region: COG3817 758793008052 Protein of unknown function (DUF979); Region: DUF979; pfam06166 758793008053 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 758793008054 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 758793008055 Mg++ binding site [ion binding]; other site 758793008056 putative catalytic motif [active] 758793008057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793008058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793008059 Walker A motif; other site 758793008060 ATP binding site [chemical binding]; other site 758793008061 Walker B motif; other site 758793008062 Predicted membrane protein [Function unknown]; Region: COG3817 758793008063 TraB family; Region: TraB; pfam01963 758793008064 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 758793008065 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793008066 Walker A/P-loop; other site 758793008067 ATP binding site [chemical binding]; other site 758793008068 Q-loop/lid; other site 758793008069 ABC transporter signature motif; other site 758793008070 Walker B; other site 758793008071 D-loop; other site 758793008072 H-loop/switch region; other site 758793008073 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 758793008074 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 758793008075 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793008076 Walker A/P-loop; other site 758793008077 ATP binding site [chemical binding]; other site 758793008078 Q-loop/lid; other site 758793008079 ABC transporter signature motif; other site 758793008080 Walker B; other site 758793008081 D-loop; other site 758793008082 H-loop/switch region; other site 758793008083 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793008084 dipeptide transporter; Provisional; Region: PRK10913 758793008085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793008086 dimer interface [polypeptide binding]; other site 758793008087 ABC-ATPase subunit interface; other site 758793008088 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758793008089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793008090 dimer interface [polypeptide binding]; other site 758793008091 conserved gate region; other site 758793008092 putative PBP binding loops; other site 758793008093 ABC-ATPase subunit interface; other site 758793008094 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793008095 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 758793008096 peptide binding site [polypeptide binding]; other site 758793008097 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 758793008098 FAD binding site [chemical binding]; other site 758793008099 Membrane protein of unknown function; Region: DUF360; pfam04020 758793008100 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 758793008101 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 758793008102 homotetramer interface [polypeptide binding]; other site 758793008103 ligand binding site [chemical binding]; other site 758793008104 catalytic site [active] 758793008105 NAD binding site [chemical binding]; other site 758793008106 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793008107 active site 758793008108 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793008109 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 758793008110 LrgA family; Region: LrgA; pfam03788 758793008111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793008112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793008113 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 758793008114 putative dimerization interface [polypeptide binding]; other site 758793008115 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793008116 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 758793008117 ligand binding site [chemical binding]; other site 758793008118 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 758793008119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793008120 active site 758793008121 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 758793008122 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 758793008123 Flagellar protein FliT; Region: FliT; pfam05400 758793008124 flagellar protein FliS; Validated; Region: fliS; PRK05685 758793008125 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 758793008126 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 758793008127 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 758793008128 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 758793008129 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 758793008130 FliG C-terminal domain; Region: FliG_C; pfam01706 758793008131 flagellar assembly protein H; Validated; Region: fliH; PRK05687 758793008132 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 758793008133 Flagellar assembly protein FliH; Region: FliH; pfam02108 758793008134 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 758793008135 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 758793008136 Walker A motif/ATP binding site; other site 758793008137 Walker B motif; other site 758793008138 Flagellar FliJ protein; Region: FliJ; pfam02050 758793008139 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 758793008140 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 758793008141 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 758793008142 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 758793008143 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 758793008144 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 758793008145 flagellar motor switch protein; Validated; Region: fliN; PRK05698 758793008146 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 758793008147 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 758793008148 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 758793008149 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 758793008150 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793008151 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 758793008152 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 758793008153 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 758793008154 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758793008155 Flagellar regulator YcgR; Region: YcgR; pfam07317 758793008156 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 758793008157 PilZ domain; Region: PilZ; pfam07238 758793008158 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 758793008159 Rod binding protein; Region: Rod-binding; cl01626 758793008160 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 758793008161 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 758793008162 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 758793008163 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 758793008164 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 758793008165 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 758793008166 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758793008167 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758793008168 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 758793008169 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758793008170 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 758793008171 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 758793008172 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758793008173 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 758793008174 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758793008175 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 758793008176 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 758793008177 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 758793008178 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 758793008179 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 758793008180 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 758793008181 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 758793008182 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 758793008183 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 758793008184 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 758793008185 FlgN protein; Region: FlgN; pfam05130 758793008186 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 758793008187 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 758793008188 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 758793008189 FHIPEP family; Region: FHIPEP; pfam00771 758793008190 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 758793008191 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 758793008192 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 758793008193 Alginate lyase; Region: Alginate_lyase; pfam05426 758793008194 glycine dehydrogenase; Provisional; Region: PRK05367 758793008195 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 758793008196 tetramer interface [polypeptide binding]; other site 758793008197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793008198 catalytic residue [active] 758793008199 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 758793008200 tetramer interface [polypeptide binding]; other site 758793008201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793008202 catalytic residue [active] 758793008203 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 758793008204 lipoyl attachment site [posttranslational modification]; other site 758793008205 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 758793008206 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 758793008207 putative oxidoreductase; Provisional; Region: PRK11579 758793008208 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793008209 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793008210 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 758793008211 Part of AAA domain; Region: AAA_19; pfam13245 758793008212 Family description; Region: UvrD_C_2; pfam13538 758793008213 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793008214 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 758793008215 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 758793008216 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793008217 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793008218 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 758793008219 [2Fe-2S] cluster binding site [ion binding]; other site 758793008220 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 758793008221 hydrophobic ligand binding site; other site 758793008222 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793008223 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793008224 metal binding site [ion binding]; metal-binding site 758793008225 active site 758793008226 I-site; other site 758793008227 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 758793008228 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793008229 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758793008230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793008231 DNA binding residues [nucleotide binding] 758793008232 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793008233 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 758793008234 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793008235 thiamine pyrophosphate protein; Validated; Region: PRK08199 758793008236 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793008237 PYR/PP interface [polypeptide binding]; other site 758793008238 dimer interface [polypeptide binding]; other site 758793008239 TPP binding site [chemical binding]; other site 758793008240 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793008241 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 758793008242 TPP-binding site [chemical binding]; other site 758793008243 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 758793008244 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 758793008245 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793008246 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 758793008247 dimerization interface [polypeptide binding]; other site 758793008248 ligand binding site [chemical binding]; other site 758793008249 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 758793008250 Predicted transcriptional regulator [Transcription]; Region: COG3905 758793008251 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 758793008252 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 758793008253 Glutamate binding site [chemical binding]; other site 758793008254 NAD binding site [chemical binding]; other site 758793008255 catalytic residues [active] 758793008256 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793008257 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 758793008258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793008259 ATP binding site [chemical binding]; other site 758793008260 putative Mg++ binding site [ion binding]; other site 758793008261 helicase superfamily c-terminal domain; Region: HELICc; smart00490 758793008262 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 758793008263 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 758793008264 substrate binding site [chemical binding]; other site 758793008265 active site 758793008266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793008267 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793008268 substrate binding pocket [chemical binding]; other site 758793008269 membrane-bound complex binding site; other site 758793008270 hinge residues; other site 758793008271 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 758793008272 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793008273 AMP-binding domain protein; Validated; Region: PRK08315 758793008274 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793008275 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 758793008276 acyl-activating enzyme (AAE) consensus motif; other site 758793008277 putative AMP binding site [chemical binding]; other site 758793008278 putative active site [active] 758793008279 putative CoA binding site [chemical binding]; other site 758793008280 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 758793008281 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 758793008282 gamma subunit interface [polypeptide binding]; other site 758793008283 epsilon subunit interface [polypeptide binding]; other site 758793008284 LBP interface [polypeptide binding]; other site 758793008285 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 758793008286 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 758793008287 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 758793008288 alpha subunit interaction interface [polypeptide binding]; other site 758793008289 Walker A motif; other site 758793008290 ATP binding site [chemical binding]; other site 758793008291 Walker B motif; other site 758793008292 inhibitor binding site; inhibition site 758793008293 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 758793008294 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 758793008295 core domain interface [polypeptide binding]; other site 758793008296 delta subunit interface [polypeptide binding]; other site 758793008297 epsilon subunit interface [polypeptide binding]; other site 758793008298 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 758793008299 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 758793008300 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 758793008301 beta subunit interaction interface [polypeptide binding]; other site 758793008302 Walker A motif; other site 758793008303 ATP binding site [chemical binding]; other site 758793008304 Walker B motif; other site 758793008305 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 758793008306 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 758793008307 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 758793008308 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 758793008309 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 758793008310 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 758793008311 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 758793008312 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 758793008313 ATP synthase I chain; Region: ATP_synt_I; pfam03899 758793008314 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 758793008315 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 758793008316 transmembrane helices; other site 758793008317 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 758793008318 ParB-like nuclease domain; Region: ParBc; pfam02195 758793008319 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 758793008320 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 758793008321 P loop; other site 758793008322 Nucleotide binding site [chemical binding]; other site 758793008323 DTAP/Switch II; other site 758793008324 Switch I; other site 758793008325 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793008326 Magnesium ion binding site [ion binding]; other site 758793008327 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 758793008328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793008329 S-adenosylmethionine binding site [chemical binding]; other site 758793008330 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 758793008331 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 758793008332 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 758793008333 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 758793008334 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793008335 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793008336 Walker A/P-loop; other site 758793008337 ATP binding site [chemical binding]; other site 758793008338 Q-loop/lid; other site 758793008339 ABC transporter signature motif; other site 758793008340 Walker B; other site 758793008341 D-loop; other site 758793008342 H-loop/switch region; other site 758793008343 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793008344 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793008345 TM-ABC transporter signature motif; other site 758793008346 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793008347 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793008348 Walker A/P-loop; other site 758793008349 ATP binding site [chemical binding]; other site 758793008350 Q-loop/lid; other site 758793008351 ABC transporter signature motif; other site 758793008352 Walker B; other site 758793008353 D-loop; other site 758793008354 H-loop/switch region; other site 758793008355 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793008356 TM-ABC transporter signature motif; other site 758793008357 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793008358 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 758793008359 putative ligand binding site [chemical binding]; other site 758793008360 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793008361 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 758793008362 putative ligand binding site [chemical binding]; other site 758793008363 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793008364 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793008365 TM-ABC transporter signature motif; other site 758793008366 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793008367 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793008368 TM-ABC transporter signature motif; other site 758793008369 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793008370 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 758793008371 putative ligand binding site [chemical binding]; other site 758793008372 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793008373 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793008374 Walker A/P-loop; other site 758793008375 ATP binding site [chemical binding]; other site 758793008376 Q-loop/lid; other site 758793008377 ABC transporter signature motif; other site 758793008378 Walker B; other site 758793008379 D-loop; other site 758793008380 H-loop/switch region; other site 758793008381 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793008382 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793008383 Walker A/P-loop; other site 758793008384 ATP binding site [chemical binding]; other site 758793008385 Q-loop/lid; other site 758793008386 ABC transporter signature motif; other site 758793008387 Walker B; other site 758793008388 D-loop; other site 758793008389 H-loop/switch region; other site 758793008390 choline dehydrogenase; Validated; Region: PRK02106 758793008391 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793008392 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793008393 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793008394 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793008395 dimerization interface [polypeptide binding]; other site 758793008396 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 758793008397 putative active site [active] 758793008398 putative metal binding residues [ion binding]; other site 758793008399 signature motif; other site 758793008400 putative triphosphate binding site [ion binding]; other site 758793008401 dimer interface [polypeptide binding]; other site 758793008402 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793008403 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 758793008404 AsnC family; Region: AsnC_trans_reg; pfam01037 758793008405 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 758793008406 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793008407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793008408 active site 758793008409 phosphorylation site [posttranslational modification] 758793008410 intermolecular recognition site; other site 758793008411 dimerization interface [polypeptide binding]; other site 758793008412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793008413 DNA binding site [nucleotide binding] 758793008414 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 758793008415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 758793008416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793008417 dimer interface [polypeptide binding]; other site 758793008418 phosphorylation site [posttranslational modification] 758793008419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793008420 ATP binding site [chemical binding]; other site 758793008421 Mg2+ binding site [ion binding]; other site 758793008422 G-X-G motif; other site 758793008423 Proteins containing SET domain [General function prediction only]; Region: COG2940 758793008424 SET domain; Region: SET; pfam00856 758793008425 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 758793008426 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 758793008427 active site 758793008428 FMN binding site [chemical binding]; other site 758793008429 substrate binding site [chemical binding]; other site 758793008430 homotetramer interface [polypeptide binding]; other site 758793008431 catalytic residue [active] 758793008432 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 758793008433 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 758793008434 catalytic triad [active] 758793008435 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793008436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793008437 putative DNA binding site [nucleotide binding]; other site 758793008438 putative Zn2+ binding site [ion binding]; other site 758793008439 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 758793008440 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 758793008441 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 758793008442 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758793008443 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 758793008444 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 758793008445 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793008446 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758793008447 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 758793008448 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 758793008449 active site residue [active] 758793008450 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 758793008451 IHF dimer interface [polypeptide binding]; other site 758793008452 IHF - DNA interface [nucleotide binding]; other site 758793008453 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 758793008454 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793008455 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 758793008456 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 758793008457 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793008458 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793008459 catalytic residue [active] 758793008460 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 758793008461 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 758793008462 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 758793008463 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 758793008464 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 758793008465 type II secretion system protein E; Region: type_II_gspE; TIGR02533 758793008466 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 758793008467 Walker A motif; other site 758793008468 ATP binding site [chemical binding]; other site 758793008469 Walker B motif; other site 758793008470 type II secretion system protein F; Region: GspF; TIGR02120 758793008471 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758793008472 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758793008473 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 758793008474 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 758793008475 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 758793008476 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 758793008477 Type II transport protein GspH; Region: GspH; pfam12019 758793008478 type II secretion system protein I; Region: gspI; TIGR01707 758793008479 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 758793008480 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 758793008481 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 758793008482 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 758793008483 GspL periplasmic domain; Region: GspL_C; pfam12693 758793008484 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 758793008485 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 758793008486 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793008487 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793008488 MarR family; Region: MarR_2; cl17246 758793008489 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 758793008490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008491 putative substrate translocation pore; other site 758793008492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008493 glutamate--cysteine ligase; Provisional; Region: PRK02107 758793008494 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 758793008495 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 758793008496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793008497 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 758793008498 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 758793008499 DNA binding site [nucleotide binding] 758793008500 active site 758793008501 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 758793008502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793008503 Walker A motif; other site 758793008504 ATP binding site [chemical binding]; other site 758793008505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793008506 Walker B motif; other site 758793008507 arginine finger; other site 758793008508 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 758793008509 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 758793008510 active site 758793008511 HslU subunit interaction site [polypeptide binding]; other site 758793008512 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 758793008513 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 758793008514 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 758793008515 P-loop, Walker A motif; other site 758793008516 Base recognition motif; other site 758793008517 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 758793008518 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 758793008519 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 758793008520 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 758793008521 putative RNA binding site [nucleotide binding]; other site 758793008522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793008523 S-adenosylmethionine binding site [chemical binding]; other site 758793008524 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 758793008525 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758793008526 active site 758793008527 DNA binding site [nucleotide binding] 758793008528 Int/Topo IB signature motif; other site 758793008529 Protein of unknown function, DUF484; Region: DUF484; cl17449 758793008530 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 758793008531 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 758793008532 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 758793008533 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 758793008534 putative acyl-acceptor binding pocket; other site 758793008535 S-adenosylmethionine synthetase; Validated; Region: PRK05250 758793008536 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 758793008537 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 758793008538 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 758793008539 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 758793008540 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 758793008541 FMN binding site [chemical binding]; other site 758793008542 active site 758793008543 substrate binding site [chemical binding]; other site 758793008544 catalytic residue [active] 758793008545 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 758793008546 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 758793008547 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793008548 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793008549 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793008550 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793008551 active site 758793008552 catalytic tetrad [active] 758793008553 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793008554 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 758793008555 FAD binding pocket [chemical binding]; other site 758793008556 FAD binding motif [chemical binding]; other site 758793008557 phosphate binding motif [ion binding]; other site 758793008558 beta-alpha-beta structure motif; other site 758793008559 NAD binding pocket [chemical binding]; other site 758793008560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 758793008561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793008562 ATP binding site [chemical binding]; other site 758793008563 Mg2+ binding site [ion binding]; other site 758793008564 G-X-G motif; other site 758793008565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793008566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793008567 active site 758793008568 phosphorylation site [posttranslational modification] 758793008569 intermolecular recognition site; other site 758793008570 dimerization interface [polypeptide binding]; other site 758793008571 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793008572 DNA binding residues [nucleotide binding] 758793008573 dimerization interface [polypeptide binding]; other site 758793008574 amino acid transporter; Region: 2A0306; TIGR00909 758793008575 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 758793008576 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793008577 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 758793008578 catalytic loop [active] 758793008579 iron binding site [ion binding]; other site 758793008580 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793008581 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793008582 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793008583 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793008584 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 758793008585 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 758793008586 MoxR-like ATPases [General function prediction only]; Region: COG0714 758793008587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793008588 Walker A motif; other site 758793008589 ATP binding site [chemical binding]; other site 758793008590 Walker B motif; other site 758793008591 arginine finger; other site 758793008592 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 758793008593 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 758793008594 metal ion-dependent adhesion site (MIDAS); other site 758793008595 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 758793008596 putative hydrophobic ligand binding site [chemical binding]; other site 758793008597 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 758793008598 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 758793008599 XdhC Rossmann domain; Region: XdhC_C; pfam13478 758793008600 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 758793008601 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 758793008602 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 758793008603 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 758793008604 BRO family, N-terminal domain; Region: Bro-N; pfam02498 758793008605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 758793008606 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 758793008607 serine/threonine protein kinase; Provisional; Region: PRK11768 758793008608 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 758793008609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008610 Dienelactone hydrolase family; Region: DLH; pfam01738 758793008611 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793008612 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 758793008613 dimerization interface [polypeptide binding]; other site 758793008614 ligand binding site [chemical binding]; other site 758793008615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008616 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793008617 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 758793008618 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 758793008619 H-NS histone family; Region: Histone_HNS; pfam00816 758793008620 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 758793008621 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 758793008622 Cation efflux family; Region: Cation_efflux; pfam01545 758793008623 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793008624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793008625 putative DNA binding site [nucleotide binding]; other site 758793008626 putative Zn2+ binding site [ion binding]; other site 758793008627 AsnC family; Region: AsnC_trans_reg; pfam01037 758793008628 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 758793008629 active site 758793008630 substrate binding site [chemical binding]; other site 758793008631 catalytic site [active] 758793008632 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 758793008633 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 758793008634 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 758793008635 Predicted methyltransferases [General function prediction only]; Region: COG0313 758793008636 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 758793008637 putative SAM binding site [chemical binding]; other site 758793008638 putative homodimer interface [polypeptide binding]; other site 758793008639 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 758793008640 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 758793008641 active site 758793008642 dimer interface [polypeptide binding]; other site 758793008643 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 758793008644 BON domain; Region: BON; pfam04972 758793008645 Cytochrome c; Region: Cytochrom_C; cl11414 758793008646 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 758793008647 dimer interface [polypeptide binding]; other site 758793008648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793008649 metal binding site [ion binding]; metal-binding site 758793008650 YaeQ protein; Region: YaeQ; pfam07152 758793008651 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793008652 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 758793008653 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 758793008654 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 758793008655 active site 758793008656 Int/Topo IB signature motif; other site 758793008657 catalytic residues [active] 758793008658 DNA binding site [nucleotide binding] 758793008659 virion protein; Provisional; Region: V; PHA02564 758793008660 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 758793008661 ssDNA binding site [nucleotide binding]; other site 758793008662 tetramer (dimer of dimers) interface [polypeptide binding]; other site 758793008663 AAA domain; Region: AAA_25; pfam13481 758793008664 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793008665 Walker A motif; other site 758793008666 ATP binding site [chemical binding]; other site 758793008667 Walker B motif; other site 758793008668 Helix-turn-helix domain; Region: HTH_39; pfam14090 758793008669 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 758793008670 active site 758793008671 Int/Topo IB signature motif; other site 758793008672 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 758793008673 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 758793008674 trmE is a tRNA modification GTPase; Region: trmE; cd04164 758793008675 G1 box; other site 758793008676 GTP/Mg2+ binding site [chemical binding]; other site 758793008677 Switch I region; other site 758793008678 G2 box; other site 758793008679 Switch II region; other site 758793008680 G3 box; other site 758793008681 G4 box; other site 758793008682 G5 box; other site 758793008683 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 758793008684 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 758793008685 membrane protein insertase; Provisional; Region: PRK01318 758793008686 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 758793008687 hypothetical protein; Validated; Region: PRK00041 758793008688 Ribonuclease P; Region: Ribonuclease_P; cl00457 758793008689 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 758793008690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008691 putative substrate translocation pore; other site 758793008692 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793008693 Initiator Replication protein; Region: Rep_3; pfam01051 758793008694 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 758793008695 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793008696 P-loop; other site 758793008697 Magnesium ion binding site [ion binding]; other site 758793008698 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793008699 Magnesium ion binding site [ion binding]; other site 758793008700 ParB-like nuclease domain; Region: ParB; smart00470 758793008701 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 758793008702 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 758793008703 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793008704 N-terminal plug; other site 758793008705 ligand-binding site [chemical binding]; other site 758793008706 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 758793008707 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 758793008708 heme binding pocket [chemical binding]; other site 758793008709 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 758793008710 Predicted permeases [General function prediction only]; Region: COG0679 758793008711 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793008712 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793008713 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793008714 putative effector binding pocket; other site 758793008715 dimerization interface [polypeptide binding]; other site 758793008716 Helix-turn-helix domain; Region: HTH_18; pfam12833 758793008717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793008718 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 758793008719 Cytochrome c; Region: Cytochrom_C; cl11414 758793008720 SnoaL-like domain; Region: SnoaL_2; pfam12680 758793008721 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793008722 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 758793008723 NAD(P) binding site [chemical binding]; other site 758793008724 catalytic residues [active] 758793008725 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 758793008726 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 758793008727 active site 758793008728 dimer interface [polypeptide binding]; other site 758793008729 metal binding site [ion binding]; metal-binding site 758793008730 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 758793008731 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 758793008732 dimer interface [polypeptide binding]; other site 758793008733 active site 758793008734 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 758793008735 iron-sulfur cluster [ion binding]; other site 758793008736 [2Fe-2S] cluster binding site [ion binding]; other site 758793008737 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793008738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793008739 DNA-binding site [nucleotide binding]; DNA binding site 758793008740 FCD domain; Region: FCD; pfam07729 758793008741 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793008742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793008743 Walker A/P-loop; other site 758793008744 ATP binding site [chemical binding]; other site 758793008745 Q-loop/lid; other site 758793008746 ABC transporter signature motif; other site 758793008747 Walker B; other site 758793008748 D-loop; other site 758793008749 H-loop/switch region; other site 758793008750 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793008751 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793008752 TM-ABC transporter signature motif; other site 758793008753 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 758793008754 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793008755 putative ligand binding site [chemical binding]; other site 758793008756 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 758793008757 Peptidase family M23; Region: Peptidase_M23; pfam01551 758793008758 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 758793008759 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 758793008760 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 758793008761 EamA-like transporter family; Region: EamA; pfam00892 758793008762 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 758793008763 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 758793008764 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 758793008765 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 758793008766 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 758793008767 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758793008768 glycerol kinase; Provisional; Region: glpK; PRK00047 758793008769 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 758793008770 N- and C-terminal domain interface [polypeptide binding]; other site 758793008771 active site 758793008772 MgATP binding site [chemical binding]; other site 758793008773 catalytic site [active] 758793008774 metal binding site [ion binding]; metal-binding site 758793008775 glycerol binding site [chemical binding]; other site 758793008776 homotetramer interface [polypeptide binding]; other site 758793008777 homodimer interface [polypeptide binding]; other site 758793008778 FBP binding site [chemical binding]; other site 758793008779 protein IIAGlc interface [polypeptide binding]; other site 758793008780 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 758793008781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793008782 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 758793008783 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793008784 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793008785 trimer interface [polypeptide binding]; other site 758793008786 eyelet of channel; other site 758793008787 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 758793008788 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 758793008789 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 758793008790 putative active site [active] 758793008791 putative catalytic site [active] 758793008792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008793 D-galactonate transporter; Region: 2A0114; TIGR00893 758793008794 putative substrate translocation pore; other site 758793008795 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793008796 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 758793008797 dimer interface [polypeptide binding]; other site 758793008798 active site 758793008799 metal binding site [ion binding]; metal-binding site 758793008800 glutathione binding site [chemical binding]; other site 758793008801 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 758793008802 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 758793008803 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793008804 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 758793008805 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793008806 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 758793008807 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793008808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793008809 dimer interface [polypeptide binding]; other site 758793008810 conserved gate region; other site 758793008811 putative PBP binding loops; other site 758793008812 ABC-ATPase subunit interface; other site 758793008813 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 758793008814 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793008815 Walker A/P-loop; other site 758793008816 ATP binding site [chemical binding]; other site 758793008817 Q-loop/lid; other site 758793008818 ABC transporter signature motif; other site 758793008819 Walker B; other site 758793008820 D-loop; other site 758793008821 H-loop/switch region; other site 758793008822 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 758793008823 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 758793008824 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 758793008825 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 758793008826 urea carboxylase; Region: urea_carbox; TIGR02712 758793008827 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758793008828 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793008829 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 758793008830 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 758793008831 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 758793008832 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 758793008833 carboxyltransferase (CT) interaction site; other site 758793008834 biotinylation site [posttranslational modification]; other site 758793008835 allophanate hydrolase; Provisional; Region: PRK08186 758793008836 Amidase; Region: Amidase; cl11426 758793008837 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 758793008838 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 758793008839 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 758793008840 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 758793008841 putative heme binding pocket [chemical binding]; other site 758793008842 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 758793008843 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793008844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793008845 DNA-binding site [nucleotide binding]; DNA binding site 758793008846 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793008847 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793008848 homodimer interface [polypeptide binding]; other site 758793008849 catalytic residue [active] 758793008850 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793008851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008852 putative substrate translocation pore; other site 758793008853 choline dehydrogenase; Validated; Region: PRK02106 758793008854 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793008855 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793008856 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793008857 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793008858 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 758793008859 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 758793008860 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793008861 PYR/PP interface [polypeptide binding]; other site 758793008862 dimer interface [polypeptide binding]; other site 758793008863 TPP binding site [chemical binding]; other site 758793008864 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793008865 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 758793008866 TPP-binding site; other site 758793008867 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793008868 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793008869 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793008870 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793008871 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793008872 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793008873 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 758793008874 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 758793008875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758793008876 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 758793008877 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 758793008878 metal ion-dependent adhesion site (MIDAS); other site 758793008879 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 758793008880 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 758793008881 active site 758793008882 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 758793008883 Na binding site [ion binding]; other site 758793008884 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 758793008885 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793008886 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 758793008887 SnoaL-like domain; Region: SnoaL_2; pfam12680 758793008888 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 758793008889 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793008890 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793008891 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793008892 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 758793008893 putative catalytic cysteine [active] 758793008894 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 758793008895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793008896 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 758793008897 acyl-activating enzyme (AAE) consensus motif; other site 758793008898 putative AMP binding site [chemical binding]; other site 758793008899 putative active site [active] 758793008900 putative CoA binding site [chemical binding]; other site 758793008901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008902 D-galactonate transporter; Region: 2A0114; TIGR00893 758793008903 putative substrate translocation pore; other site 758793008904 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 758793008905 Clp amino terminal domain; Region: Clp_N; pfam02861 758793008906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793008907 Walker A motif; other site 758793008908 ATP binding site [chemical binding]; other site 758793008909 Walker B motif; other site 758793008910 arginine finger; other site 758793008911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793008912 Walker A motif; other site 758793008913 ATP binding site [chemical binding]; other site 758793008914 Walker B motif; other site 758793008915 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 758793008916 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 758793008917 Protein of unknown function (DUF770); Region: DUF770; pfam05591 758793008918 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 758793008919 Protein of unknown function (DUF877); Region: DUF877; pfam05943 758793008920 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 758793008921 active site 758793008922 benzoate transport; Region: 2A0115; TIGR00895 758793008923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008924 putative substrate translocation pore; other site 758793008925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793008926 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 758793008927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793008928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 758793008929 active site 758793008930 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 758793008931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793008932 putative active site [active] 758793008933 putative metal binding site [ion binding]; other site 758793008934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793008935 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 758793008936 NAD(P) binding site [chemical binding]; other site 758793008937 catalytic residues [active] 758793008938 L-aspartate dehydrogenase; Provisional; Region: PRK13303 758793008939 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 758793008940 Domain of unknown function DUF108; Region: DUF108; pfam01958 758793008941 hypothetical protein; Provisional; Region: PRK07064 758793008942 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793008943 PYR/PP interface [polypeptide binding]; other site 758793008944 dimer interface [polypeptide binding]; other site 758793008945 TPP binding site [chemical binding]; other site 758793008946 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793008947 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 758793008948 TPP-binding site [chemical binding]; other site 758793008949 short chain dehydrogenase; Provisional; Region: PRK07062 758793008950 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 758793008951 putative NAD(P) binding site [chemical binding]; other site 758793008952 putative active site [active] 758793008953 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793008954 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793008955 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793008956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793008957 Serine hydrolase; Region: Ser_hydrolase; cl17834 758793008958 Cupin domain; Region: Cupin_2; pfam07883 758793008959 short chain dehydrogenase; Provisional; Region: PRK12939 758793008960 classical (c) SDRs; Region: SDR_c; cd05233 758793008961 NAD(P) binding site [chemical binding]; other site 758793008962 active site 758793008963 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793008964 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 758793008965 [2Fe-2S] cluster binding site [ion binding]; other site 758793008966 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 758793008967 hydrophobic ligand binding site; other site 758793008968 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 758793008969 [2Fe-2S] cluster binding site [ion binding]; other site 758793008970 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793008971 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793008972 trimer interface [polypeptide binding]; other site 758793008973 eyelet of channel; other site 758793008974 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793008975 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793008976 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793008977 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758793008978 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 758793008979 hypothetical protein; Provisional; Region: PRK06184 758793008980 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793008981 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793008982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793008983 S-adenosylmethionine binding site [chemical binding]; other site 758793008984 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793008985 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 758793008986 NADP binding site [chemical binding]; other site 758793008987 homodimer interface [polypeptide binding]; other site 758793008988 active site 758793008989 substrate binding site [chemical binding]; other site 758793008990 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793008991 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 758793008992 glutathionine S-transferase; Provisional; Region: PRK10542 758793008993 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 758793008994 C-terminal domain interface [polypeptide binding]; other site 758793008995 GSH binding site (G-site) [chemical binding]; other site 758793008996 dimer interface [polypeptide binding]; other site 758793008997 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 758793008998 dimer interface [polypeptide binding]; other site 758793008999 substrate binding pocket (H-site) [chemical binding]; other site 758793009000 N-terminal domain interface [polypeptide binding]; other site 758793009001 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 758793009002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009003 putative substrate translocation pore; other site 758793009004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793009005 Coenzyme A binding pocket [chemical binding]; other site 758793009006 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 758793009007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009008 NAD(P) binding site [chemical binding]; other site 758793009009 active site 758793009010 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 758793009011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009012 NAD(P) binding site [chemical binding]; other site 758793009013 active site 758793009014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793009015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793009016 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 758793009017 ProQ/FINO family; Region: ProQ; pfam04352 758793009018 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 758793009019 NADP binding site [chemical binding]; other site 758793009020 active site 758793009021 steroid binding site; other site 758793009022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009024 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793009025 putative effector binding pocket; other site 758793009026 dimerization interface [polypeptide binding]; other site 758793009027 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793009028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009029 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793009030 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 758793009031 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 758793009032 putative active site [active] 758793009033 Zn binding site [ion binding]; other site 758793009034 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009035 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009036 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 758793009037 dimerization interface [polypeptide binding]; other site 758793009038 substrate binding pocket [chemical binding]; other site 758793009039 putative S-transferase; Provisional; Region: PRK11752 758793009040 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 758793009041 C-terminal domain interface [polypeptide binding]; other site 758793009042 GSH binding site (G-site) [chemical binding]; other site 758793009043 dimer interface [polypeptide binding]; other site 758793009044 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 758793009045 dimer interface [polypeptide binding]; other site 758793009046 N-terminal domain interface [polypeptide binding]; other site 758793009047 active site 758793009048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793009049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793009050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793009051 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 758793009052 active site 758793009053 metal binding site [ion binding]; metal-binding site 758793009054 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793009055 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 758793009056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009057 putative substrate translocation pore; other site 758793009058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009059 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 758793009060 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793009061 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793009062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793009063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793009064 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 758793009065 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 758793009066 Clp amino terminal domain; Region: Clp_N; pfam02861 758793009067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793009068 Walker A motif; other site 758793009069 ATP binding site [chemical binding]; other site 758793009070 Walker B motif; other site 758793009071 arginine finger; other site 758793009072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793009073 Walker A motif; other site 758793009074 ATP binding site [chemical binding]; other site 758793009075 Walker B motif; other site 758793009076 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 758793009077 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 758793009078 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 758793009079 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 758793009080 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 758793009081 DNA-binding site [nucleotide binding]; DNA binding site 758793009082 RNA-binding motif; other site 758793009083 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793009084 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 758793009085 putative DNA binding site [nucleotide binding]; other site 758793009086 putative Zn2+ binding site [ion binding]; other site 758793009087 AsnC family; Region: AsnC_trans_reg; pfam01037 758793009088 aromatic amino acid transporter; Provisional; Region: PRK10238 758793009089 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 758793009090 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 758793009091 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 758793009092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793009093 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793009094 DNA binding residues [nucleotide binding] 758793009095 dimerization interface [polypeptide binding]; other site 758793009096 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793009097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793009098 active site 758793009099 phosphorylation site [posttranslational modification] 758793009100 intermolecular recognition site; other site 758793009101 dimerization interface [polypeptide binding]; other site 758793009102 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793009103 DNA binding site [nucleotide binding] 758793009104 Domain of unknown function (DU1801); Region: DUF1801; cl17490 758793009105 Methyltransferase domain; Region: Methyltransf_31; pfam13847 758793009106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793009107 S-adenosylmethionine binding site [chemical binding]; other site 758793009108 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 758793009109 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793009110 N-terminal plug; other site 758793009111 ligand-binding site [chemical binding]; other site 758793009112 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793009113 NMT1-like family; Region: NMT1_2; pfam13379 758793009114 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 758793009115 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 758793009116 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 758793009117 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 758793009118 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 758793009119 active site clefts [active] 758793009120 zinc binding site [ion binding]; other site 758793009121 dimer interface [polypeptide binding]; other site 758793009122 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 758793009123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009124 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 758793009125 putative dimerization interface [polypeptide binding]; other site 758793009126 putative substrate binding pocket [chemical binding]; other site 758793009127 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 758793009128 proximal quinone binding site [chemical binding]; other site 758793009129 SdhD (CybS) interface [polypeptide binding]; other site 758793009130 proximal heme binding site [chemical binding]; other site 758793009131 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 758793009132 SdhC subunit interface [polypeptide binding]; other site 758793009133 proximal heme binding site [chemical binding]; other site 758793009134 cardiolipin binding site; other site 758793009135 Iron-sulfur protein interface; other site 758793009136 proximal quinone binding site [chemical binding]; other site 758793009137 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 758793009138 L-aspartate oxidase; Provisional; Region: PRK06175 758793009139 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 758793009140 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 758793009141 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 758793009142 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 758793009143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 758793009144 Ferritin-like domain; Region: Ferritin_2; pfam13668 758793009145 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793009146 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793009147 DinB family; Region: DinB; cl17821 758793009148 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 758793009149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793009150 DNA-binding site [nucleotide binding]; DNA binding site 758793009151 FCD domain; Region: FCD; pfam07729 758793009152 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 758793009153 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793009154 Walker A/P-loop; other site 758793009155 ATP binding site [chemical binding]; other site 758793009156 Q-loop/lid; other site 758793009157 ABC transporter signature motif; other site 758793009158 Walker B; other site 758793009159 D-loop; other site 758793009160 H-loop/switch region; other site 758793009161 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793009162 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 758793009163 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793009164 Walker A/P-loop; other site 758793009165 ATP binding site [chemical binding]; other site 758793009166 Q-loop/lid; other site 758793009167 ABC transporter signature motif; other site 758793009168 Walker B; other site 758793009169 D-loop; other site 758793009170 H-loop/switch region; other site 758793009171 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793009172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 758793009173 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 758793009174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793009175 dimer interface [polypeptide binding]; other site 758793009176 conserved gate region; other site 758793009177 putative PBP binding loops; other site 758793009178 ABC-ATPase subunit interface; other site 758793009179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758793009180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793009181 dimer interface [polypeptide binding]; other site 758793009182 conserved gate region; other site 758793009183 putative PBP binding loops; other site 758793009184 ABC-ATPase subunit interface; other site 758793009185 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793009186 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 758793009187 Isochorismatase family; Region: Isochorismatase; pfam00857 758793009188 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 758793009189 catalytic triad [active] 758793009190 conserved cis-peptide bond; other site 758793009191 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 758793009192 catalytic residues [active] 758793009193 DinB superfamily; Region: DinB_2; pfam12867 758793009194 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 758793009195 Amidase; Region: Amidase; cl11426 758793009196 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 758793009197 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793009198 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793009199 short chain dehydrogenase; Provisional; Region: PRK07035 758793009200 classical (c) SDRs; Region: SDR_c; cd05233 758793009201 NAD(P) binding site [chemical binding]; other site 758793009202 active site 758793009203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009204 D-galactonate transporter; Region: 2A0114; TIGR00893 758793009205 putative substrate translocation pore; other site 758793009206 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 758793009207 benzoate transport; Region: 2A0115; TIGR00895 758793009208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009209 putative substrate translocation pore; other site 758793009210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009211 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 758793009212 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793009213 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793009214 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793009215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793009216 DNA-binding site [nucleotide binding]; DNA binding site 758793009217 FCD domain; Region: FCD; pfam07729 758793009218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009220 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 758793009221 putative dimerization interface [polypeptide binding]; other site 758793009222 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 758793009223 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 758793009224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009225 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793009226 putative substrate translocation pore; other site 758793009227 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793009228 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 758793009229 putative FMN binding site [chemical binding]; other site 758793009230 riboflavin synthase subunit beta; Provisional; Region: PRK12419 758793009231 active site 758793009232 homopentamer interface [polypeptide binding]; other site 758793009233 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 758793009234 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 758793009235 putative active site [active] 758793009236 metal binding site [ion binding]; metal-binding site 758793009237 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 758793009238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793009241 dimerization interface [polypeptide binding]; other site 758793009242 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 758793009243 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 758793009244 active site 758793009245 non-prolyl cis peptide bond; other site 758793009246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009247 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793009248 putative substrate translocation pore; other site 758793009249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009251 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 758793009252 putative dimerization interface [polypeptide binding]; other site 758793009253 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 758793009254 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 758793009255 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 758793009256 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793009257 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793009258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009259 D-galactonate transporter; Region: 2A0114; TIGR00893 758793009260 putative substrate translocation pore; other site 758793009261 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 758793009262 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 758793009263 active site 758793009264 non-prolyl cis peptide bond; other site 758793009265 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 758793009266 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 758793009267 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793009268 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 758793009269 putative C-terminal domain interface [polypeptide binding]; other site 758793009270 putative GSH binding site (G-site) [chemical binding]; other site 758793009271 putative dimer interface [polypeptide binding]; other site 758793009272 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 758793009273 putative N-terminal domain interface [polypeptide binding]; other site 758793009274 putative dimer interface [polypeptide binding]; other site 758793009275 putative substrate binding pocket (H-site) [chemical binding]; other site 758793009276 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 758793009277 active site clefts [active] 758793009278 zinc binding site [ion binding]; other site 758793009279 dimer interface [polypeptide binding]; other site 758793009280 cyanate hydratase; Validated; Region: PRK02866 758793009281 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 758793009282 oligomer interface [polypeptide binding]; other site 758793009283 active site 758793009284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009285 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 758793009286 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 758793009287 dimerization interface [polypeptide binding]; other site 758793009288 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 758793009289 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 758793009290 putative ion selectivity filter; other site 758793009291 putative pore gating glutamate residue; other site 758793009292 malate dehydrogenase; Provisional; Region: PRK13529 758793009293 Malic enzyme, N-terminal domain; Region: malic; pfam00390 758793009294 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 758793009295 NAD(P) binding site [chemical binding]; other site 758793009296 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793009297 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 758793009298 FAD binding pocket [chemical binding]; other site 758793009299 conserved FAD binding motif [chemical binding]; other site 758793009300 beta-alpha-beta structure motif; other site 758793009301 NAD binding pocket [chemical binding]; other site 758793009302 benzoate transport; Region: 2A0115; TIGR00895 758793009303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009304 putative substrate translocation pore; other site 758793009305 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009307 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793009308 putative effector binding pocket; other site 758793009309 dimerization interface [polypeptide binding]; other site 758793009310 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 758793009311 putative hydrophobic ligand binding site [chemical binding]; other site 758793009312 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 758793009313 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793009314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009315 NADH(P)-binding; Region: NAD_binding_10; pfam13460 758793009316 NAD(P) binding site [chemical binding]; other site 758793009317 active site 758793009318 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 758793009319 metal ion-dependent adhesion site (MIDAS); other site 758793009320 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 758793009321 metal ion-dependent adhesion site (MIDAS); other site 758793009322 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 758793009323 Protein of unknown function DUF58; Region: DUF58; pfam01882 758793009324 MoxR-like ATPases [General function prediction only]; Region: COG0714 758793009325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758793009326 H-NS histone family; Region: Histone_HNS; pfam00816 758793009327 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 758793009328 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 758793009329 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793009330 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793009331 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793009332 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 758793009333 putative ligand binding site [chemical binding]; other site 758793009334 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793009335 TM-ABC transporter signature motif; other site 758793009336 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793009337 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793009338 TM-ABC transporter signature motif; other site 758793009339 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 758793009340 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793009341 Walker A/P-loop; other site 758793009342 ATP binding site [chemical binding]; other site 758793009343 Q-loop/lid; other site 758793009344 ABC transporter signature motif; other site 758793009345 Walker B; other site 758793009346 D-loop; other site 758793009347 H-loop/switch region; other site 758793009348 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793009349 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793009350 Walker A/P-loop; other site 758793009351 ATP binding site [chemical binding]; other site 758793009352 Q-loop/lid; other site 758793009353 ABC transporter signature motif; other site 758793009354 Walker B; other site 758793009355 D-loop; other site 758793009356 H-loop/switch region; other site 758793009357 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 758793009358 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793009359 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 758793009360 ligand binding site [chemical binding]; other site 758793009361 regulator interaction site; other site 758793009362 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 758793009363 ANTAR domain; Region: ANTAR; pfam03861 758793009364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793009365 classical (c) SDRs; Region: SDR_c; cd05233 758793009366 NAD(P) binding site [chemical binding]; other site 758793009367 active site 758793009368 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758793009369 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 758793009370 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758793009371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793009372 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 758793009373 substrate binding site [chemical binding]; other site 758793009374 ATP binding site [chemical binding]; other site 758793009375 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 758793009376 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793009377 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793009378 TM-ABC transporter signature motif; other site 758793009379 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 758793009380 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793009381 ligand binding site [chemical binding]; other site 758793009382 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793009383 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793009384 Walker A/P-loop; other site 758793009385 ATP binding site [chemical binding]; other site 758793009386 Q-loop/lid; other site 758793009387 ABC transporter signature motif; other site 758793009388 Walker B; other site 758793009389 D-loop; other site 758793009390 H-loop/switch region; other site 758793009391 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793009392 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 758793009393 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 758793009394 Metal-binding active site; metal-binding site 758793009395 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 758793009396 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 758793009397 nudix motif; other site 758793009398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 758793009399 MOSC domain; Region: MOSC; pfam03473 758793009400 3-alpha domain; Region: 3-alpha; pfam03475 758793009401 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793009402 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 758793009403 FAD binding pocket [chemical binding]; other site 758793009404 FAD binding motif [chemical binding]; other site 758793009405 phosphate binding motif [ion binding]; other site 758793009406 beta-alpha-beta structure motif; other site 758793009407 NAD binding pocket [chemical binding]; other site 758793009408 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793009409 catalytic loop [active] 758793009410 iron binding site [ion binding]; other site 758793009411 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 758793009412 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 758793009413 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 758793009414 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 758793009415 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 758793009416 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793009417 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793009418 eyelet of channel; other site 758793009419 trimer interface [polypeptide binding]; other site 758793009420 Predicted transcriptional regulator [Transcription]; Region: COG2345 758793009421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793009422 putative DNA binding site [nucleotide binding]; other site 758793009423 putative Zn2+ binding site [ion binding]; other site 758793009424 V4R domain; Region: V4R; cl15268 758793009425 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793009426 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793009427 active site 758793009428 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793009429 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793009430 active site 758793009431 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 758793009432 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 758793009433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009434 NAD(P) binding site [chemical binding]; other site 758793009435 active site 758793009436 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 758793009437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009438 NAD(P) binding site [chemical binding]; other site 758793009439 active site 758793009440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009441 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793009442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009443 short chain dehydrogenase; Provisional; Region: PRK06500 758793009444 classical (c) SDRs; Region: SDR_c; cd05233 758793009445 NAD(P) binding site [chemical binding]; other site 758793009446 active site 758793009447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009449 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793009450 putative effector binding pocket; other site 758793009451 dimerization interface [polypeptide binding]; other site 758793009452 YCII-related domain; Region: YCII; cl00999 758793009453 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 758793009454 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 758793009455 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 758793009456 FMN binding site [chemical binding]; other site 758793009457 active site 758793009458 substrate binding site [chemical binding]; other site 758793009459 catalytic residue [active] 758793009460 Predicted transcriptional regulator [Transcription]; Region: COG1959 758793009461 Transcriptional regulator; Region: Rrf2; pfam02082 758793009462 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 758793009463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793009464 motif II; other site 758793009465 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009467 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793009468 dimerization interface [polypeptide binding]; other site 758793009469 hypothetical protein; Provisional; Region: PRK11171 758793009470 Cupin domain; Region: Cupin_2; pfam07883 758793009471 Cupin domain; Region: Cupin_2; pfam07883 758793009472 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793009473 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758793009474 active site 758793009475 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793009476 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793009477 mercuric reductase; Validated; Region: PRK06370 758793009478 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793009479 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793009480 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 758793009481 homotrimer interaction site [polypeptide binding]; other site 758793009482 putative active site [active] 758793009483 mercuric reductase; Validated; Region: PRK06370 758793009484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793009485 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793009486 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793009487 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 758793009488 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 758793009489 Cupin; Region: Cupin_6; pfam12852 758793009490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009491 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793009492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009493 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 758793009494 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793009495 MarR family; Region: MarR_2; pfam12802 758793009496 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 758793009497 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 758793009498 putative ion selectivity filter; other site 758793009499 putative pore gating glutamate residue; other site 758793009500 putative H+/Cl- coupling transport residue; other site 758793009501 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 758793009502 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 758793009503 substrate binding site [chemical binding]; other site 758793009504 ligand binding site [chemical binding]; other site 758793009505 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 758793009506 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 758793009507 hypothetical protein; Provisional; Region: PRK14812 758793009508 substrate binding site [chemical binding]; other site 758793009509 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 758793009510 tartrate dehydrogenase; Region: TTC; TIGR02089 758793009511 NMT1-like family; Region: NMT1_2; pfam13379 758793009512 NMT1/THI5 like; Region: NMT1; pfam09084 758793009513 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793009514 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793009515 Walker A/P-loop; other site 758793009516 ATP binding site [chemical binding]; other site 758793009517 Q-loop/lid; other site 758793009518 ABC transporter signature motif; other site 758793009519 Walker B; other site 758793009520 D-loop; other site 758793009521 H-loop/switch region; other site 758793009522 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793009523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793009524 dimer interface [polypeptide binding]; other site 758793009525 conserved gate region; other site 758793009526 putative PBP binding loops; other site 758793009527 ABC-ATPase subunit interface; other site 758793009528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793009529 classical (c) SDRs; Region: SDR_c; cd05233 758793009530 NAD(P) binding site [chemical binding]; other site 758793009531 active site 758793009532 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 758793009533 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793009534 NMT1-like family; Region: NMT1_2; pfam13379 758793009535 NMT1/THI5 like; Region: NMT1; pfam09084 758793009536 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 758793009537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009539 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 758793009540 putative dimerization interface [polypeptide binding]; other site 758793009541 Rrf2 family protein; Region: rrf2_super; TIGR00738 758793009542 Transcriptional regulator; Region: Rrf2; pfam02082 758793009543 enoyl-CoA hydratase; Provisional; Region: PRK06688 758793009544 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793009545 substrate binding site [chemical binding]; other site 758793009546 oxyanion hole (OAH) forming residues; other site 758793009547 trimer interface [polypeptide binding]; other site 758793009548 short chain dehydrogenase; Provisional; Region: PRK06172 758793009549 classical (c) SDRs; Region: SDR_c; cd05233 758793009550 NAD(P) binding site [chemical binding]; other site 758793009551 active site 758793009552 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758793009553 Class I aldolases; Region: Aldolase_Class_I; cl17187 758793009554 catalytic residue [active] 758793009555 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 758793009556 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 758793009557 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 758793009558 NAD(P) binding pocket [chemical binding]; other site 758793009559 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758793009560 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793009561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009563 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 758793009564 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793009565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793009566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793009567 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 758793009568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009569 NAD(P) binding site [chemical binding]; other site 758793009570 active site 758793009571 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 758793009572 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793009573 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793009574 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793009575 trimer interface [polypeptide binding]; other site 758793009576 eyelet of channel; other site 758793009577 benzoate transport; Region: 2A0115; TIGR00895 758793009578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009579 putative substrate translocation pore; other site 758793009580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009581 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 758793009582 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 758793009583 active site 758793009584 non-prolyl cis peptide bond; other site 758793009585 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793009586 MarR family; Region: MarR; pfam01047 758793009587 beta-ketothiolase; Provisional; Region: PRK09051 758793009588 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793009589 dimer interface [polypeptide binding]; other site 758793009590 active site 758793009591 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 758793009592 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 758793009593 putative catalytic residue [active] 758793009594 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 758793009595 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 758793009596 putative NAD(P) binding site [chemical binding]; other site 758793009597 active site 758793009598 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 758793009599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009600 NAD(P) binding site [chemical binding]; other site 758793009601 active site 758793009602 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793009603 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793009604 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793009605 dimer interface [polypeptide binding]; other site 758793009606 N-terminal domain interface [polypeptide binding]; other site 758793009607 substrate binding pocket (H-site) [chemical binding]; other site 758793009608 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793009609 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793009610 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 758793009611 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 758793009612 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 758793009613 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793009614 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793009615 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793009616 N-terminal domain interface [polypeptide binding]; other site 758793009617 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 758793009618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009620 phenol 2-monooxygenase; Provisional; Region: PRK08294 758793009621 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 758793009622 dimer interface [polypeptide binding]; other site 758793009623 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793009624 MarR family; Region: MarR; pfam01047 758793009625 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 758793009626 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793009627 putative ligand binding site [chemical binding]; other site 758793009628 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793009629 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793009630 Walker A/P-loop; other site 758793009631 ATP binding site [chemical binding]; other site 758793009632 Q-loop/lid; other site 758793009633 ABC transporter signature motif; other site 758793009634 Walker B; other site 758793009635 D-loop; other site 758793009636 H-loop/switch region; other site 758793009637 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793009638 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793009639 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793009640 TM-ABC transporter signature motif; other site 758793009641 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793009642 TM-ABC transporter signature motif; other site 758793009643 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 758793009644 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 758793009645 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793009646 putative ligand binding site [chemical binding]; other site 758793009647 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 758793009648 Predicted permeases [General function prediction only]; Region: COG0679 758793009649 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 758793009650 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 758793009651 putative molybdopterin cofactor binding site [chemical binding]; other site 758793009652 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 758793009653 putative molybdopterin cofactor binding site; other site 758793009654 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 758793009655 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793009656 NAD binding site [chemical binding]; other site 758793009657 metal binding site [ion binding]; metal-binding site 758793009658 active site 758793009659 thiamine pyrophosphate protein; Provisional; Region: PRK08273 758793009660 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 758793009661 PYR/PP interface [polypeptide binding]; other site 758793009662 dimer interface [polypeptide binding]; other site 758793009663 tetramer interface [polypeptide binding]; other site 758793009664 TPP binding site [chemical binding]; other site 758793009665 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793009666 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 758793009667 TPP-binding site [chemical binding]; other site 758793009668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793009669 active site 758793009670 phosphorylation site [posttranslational modification] 758793009671 intermolecular recognition site; other site 758793009672 dimerization interface [polypeptide binding]; other site 758793009673 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793009674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793009675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793009676 dimer interface [polypeptide binding]; other site 758793009677 phosphorylation site [posttranslational modification] 758793009678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793009679 ATP binding site [chemical binding]; other site 758793009680 Mg2+ binding site [ion binding]; other site 758793009681 G-X-G motif; other site 758793009682 Hemerythrin-like domain; Region: Hr-like; cd12108 758793009683 Fe binding site [ion binding]; other site 758793009684 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793009685 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793009686 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793009687 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 758793009688 Amidase; Region: Amidase; pfam01425 758793009689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793009690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793009691 MarR family; Region: MarR_2; cl17246 758793009692 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793009693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793009694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009695 putative substrate translocation pore; other site 758793009696 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 758793009697 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 758793009698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793009701 dimerization interface [polypeptide binding]; other site 758793009702 MORN repeat; Region: MORN; cl14787 758793009703 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 758793009704 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758793009705 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 758793009706 Walker A/P-loop; other site 758793009707 ATP binding site [chemical binding]; other site 758793009708 Q-loop/lid; other site 758793009709 ABC transporter signature motif; other site 758793009710 Walker B; other site 758793009711 D-loop; other site 758793009712 H-loop/switch region; other site 758793009713 Isochorismatase family; Region: Isochorismatase; pfam00857 758793009714 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 758793009715 catalytic triad [active] 758793009716 conserved cis-peptide bond; other site 758793009717 Predicted membrane protein [Function unknown]; Region: COG2259 758793009718 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 758793009719 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 758793009720 active site 758793009721 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 758793009722 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793009723 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 758793009724 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 758793009725 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 758793009726 N- and C-terminal domain interface [polypeptide binding]; other site 758793009727 active site 758793009728 MgATP binding site [chemical binding]; other site 758793009729 catalytic site [active] 758793009730 metal binding site [ion binding]; metal-binding site 758793009731 carbohydrate binding site [chemical binding]; other site 758793009732 putative homodimer interface [polypeptide binding]; other site 758793009733 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 758793009734 classical (c) SDRs; Region: SDR_c; cd05233 758793009735 NAD(P) binding site [chemical binding]; other site 758793009736 active site 758793009737 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 758793009738 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793009739 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793009740 TM-ABC transporter signature motif; other site 758793009741 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758793009742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793009743 Walker A/P-loop; other site 758793009744 ATP binding site [chemical binding]; other site 758793009745 Q-loop/lid; other site 758793009746 ABC transporter signature motif; other site 758793009747 Walker B; other site 758793009748 D-loop; other site 758793009749 H-loop/switch region; other site 758793009750 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 758793009751 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 758793009752 putative ligand binding site [chemical binding]; other site 758793009753 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758793009754 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793009755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009756 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 758793009757 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 758793009758 heme binding site [chemical binding]; other site 758793009759 ferroxidase pore; other site 758793009760 ferroxidase diiron center [ion binding]; other site 758793009761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009763 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 758793009764 putative dimerization interface [polypeptide binding]; other site 758793009765 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 758793009766 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758793009767 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 758793009768 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758793009769 citrate-proton symporter; Provisional; Region: PRK15075 758793009770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009771 putative substrate translocation pore; other site 758793009772 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 758793009773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793009774 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793009775 substrate binding pocket [chemical binding]; other site 758793009776 membrane-bound complex binding site; other site 758793009777 hinge residues; other site 758793009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793009779 dimer interface [polypeptide binding]; other site 758793009780 conserved gate region; other site 758793009781 ABC-ATPase subunit interface; other site 758793009782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793009783 dimer interface [polypeptide binding]; other site 758793009784 conserved gate region; other site 758793009785 putative PBP binding loops; other site 758793009786 ABC-ATPase subunit interface; other site 758793009787 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758793009788 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793009789 Walker A/P-loop; other site 758793009790 ATP binding site [chemical binding]; other site 758793009791 Q-loop/lid; other site 758793009792 ABC transporter signature motif; other site 758793009793 Walker B; other site 758793009794 D-loop; other site 758793009795 H-loop/switch region; other site 758793009796 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793009797 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 758793009798 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793009799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793009800 DNA-binding site [nucleotide binding]; DNA binding site 758793009801 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793009802 FCD domain; Region: FCD; pfam07729 758793009803 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 758793009804 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 758793009805 NADP binding site [chemical binding]; other site 758793009806 homodimer interface [polypeptide binding]; other site 758793009807 active site 758793009808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009809 D-galactonate transporter; Region: 2A0114; TIGR00893 758793009810 putative substrate translocation pore; other site 758793009811 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 758793009812 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 758793009813 metal binding site [ion binding]; metal-binding site 758793009814 substrate binding pocket [chemical binding]; other site 758793009815 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 758793009816 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 758793009817 galactarate dehydratase; Region: galactar-dH20; TIGR03248 758793009818 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 758793009819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009820 D-galactonate transporter; Region: 2A0114; TIGR00893 758793009821 putative substrate translocation pore; other site 758793009822 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793009823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009824 NAD(P) binding site [chemical binding]; other site 758793009825 active site 758793009826 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793009827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758793009828 active site 758793009829 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 758793009830 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 758793009831 putative ligand binding site [chemical binding]; other site 758793009832 NAD binding site [chemical binding]; other site 758793009833 catalytic site [active] 758793009834 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793009835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009836 putative substrate translocation pore; other site 758793009837 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758793009838 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 758793009839 inhibitor site; inhibition site 758793009840 active site 758793009841 dimer interface [polypeptide binding]; other site 758793009842 catalytic residue [active] 758793009843 dihydroxy-acid dehydratase; Validated; Region: PRK06131 758793009844 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009845 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009846 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 758793009847 putative dimerization interface [polypeptide binding]; other site 758793009848 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 758793009849 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 758793009850 active site pocket [active] 758793009851 Cupin; Region: Cupin_6; pfam12852 758793009852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009853 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793009854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793009855 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 758793009856 Methyltransferase domain; Region: Methyltransf_11; pfam08241 758793009857 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 758793009858 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 758793009859 Response regulator receiver domain; Region: Response_reg; pfam00072 758793009860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793009861 active site 758793009862 phosphorylation site [posttranslational modification] 758793009863 intermolecular recognition site; other site 758793009864 dimerization interface [polypeptide binding]; other site 758793009865 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 758793009866 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 758793009867 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 758793009868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793009869 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 758793009870 putative ADP-binding pocket [chemical binding]; other site 758793009871 Tannase and feruloyl esterase; Region: Tannase; pfam07519 758793009872 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 758793009873 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793009874 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793009875 active site 758793009876 catalytic tetrad [active] 758793009877 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793009878 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793009879 active site 758793009880 catalytic tetrad [active] 758793009881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793009882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009883 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793009884 putative effector binding pocket; other site 758793009885 dimerization interface [polypeptide binding]; other site 758793009886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793009887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793009889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009890 SnoaL-like domain; Region: SnoaL_4; pfam13577 758793009891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793009892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793009893 AAA ATPase domain; Region: AAA_16; pfam13191 758793009894 AAA domain; Region: AAA_22; pfam13401 758793009895 RES domain; Region: RES; pfam08808 758793009896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758793009897 YCII-related domain; Region: YCII; cl00999 758793009898 Phasin protein; Region: Phasin_2; pfam09361 758793009899 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 758793009900 Coenzyme A transferase; Region: CoA_trans; smart00882 758793009901 Coenzyme A transferase; Region: CoA_trans; cl17247 758793009902 acetolactate synthase; Reviewed; Region: PRK08322 758793009903 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793009904 PYR/PP interface [polypeptide binding]; other site 758793009905 dimer interface [polypeptide binding]; other site 758793009906 TPP binding site [chemical binding]; other site 758793009907 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793009908 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 758793009909 TPP-binding site [chemical binding]; other site 758793009910 dimer interface [polypeptide binding]; other site 758793009911 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 758793009912 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 758793009913 NAD binding site [chemical binding]; other site 758793009914 catalytic Zn binding site [ion binding]; other site 758793009915 substrate binding site [chemical binding]; other site 758793009916 structural Zn binding site [ion binding]; other site 758793009917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793009918 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793009919 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 758793009920 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 758793009921 ATP binding site [chemical binding]; other site 758793009922 Mg++ binding site [ion binding]; other site 758793009923 motif III; other site 758793009924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793009925 nucleotide binding region [chemical binding]; other site 758793009926 ATP-binding site [chemical binding]; other site 758793009927 Condensation domain; Region: Condensation; pfam00668 758793009928 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 758793009929 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 758793009930 acyl-activating enzyme (AAE) consensus motif; other site 758793009931 AMP binding site [chemical binding]; other site 758793009932 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 758793009933 Condensation domain; Region: Condensation; pfam00668 758793009934 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 758793009935 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 758793009936 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 758793009937 acyl-activating enzyme (AAE) consensus motif; other site 758793009938 AMP binding site [chemical binding]; other site 758793009939 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 758793009940 thioester reductase domain; Region: Thioester-redct; TIGR01746 758793009941 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 758793009942 putative NAD(P) binding site [chemical binding]; other site 758793009943 active site 758793009944 putative substrate binding site [chemical binding]; other site 758793009945 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793009946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793009947 DNA-binding site [nucleotide binding]; DNA binding site 758793009948 FCD domain; Region: FCD; pfam07729 758793009949 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 758793009950 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 758793009951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009952 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 758793009953 putative substrate translocation pore; other site 758793009954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009955 GAF domain; Region: GAF; pfam01590 758793009956 benzoate transport; Region: 2A0115; TIGR00895 758793009957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793009958 putative substrate translocation pore; other site 758793009959 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 758793009960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793009961 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 758793009962 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793009963 dimerization interface [polypeptide binding]; other site 758793009964 substrate binding pocket [chemical binding]; other site 758793009965 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 758793009966 TPP-binding site [chemical binding]; other site 758793009967 dimer interface [polypeptide binding]; other site 758793009968 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 758793009969 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758793009970 PYR/PP interface [polypeptide binding]; other site 758793009971 dimer interface [polypeptide binding]; other site 758793009972 TPP binding site [chemical binding]; other site 758793009973 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793009974 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793009975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793009976 NAD(P) binding site [chemical binding]; other site 758793009977 active site 758793009978 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 758793009979 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 758793009980 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 758793009981 DctM-like transporters; Region: DctM; pfam06808 758793009982 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 758793009983 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 758793009984 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 758793009985 TPP-binding site [chemical binding]; other site 758793009986 dimer interface [polypeptide binding]; other site 758793009987 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758793009988 PYR/PP interface [polypeptide binding]; other site 758793009989 dimer interface [polypeptide binding]; other site 758793009990 TPP binding site [chemical binding]; other site 758793009991 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793009992 glycerate dehydrogenase; Provisional; Region: PRK06932 758793009993 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 758793009994 putative ligand binding site [chemical binding]; other site 758793009995 putative NAD binding site [chemical binding]; other site 758793009996 catalytic site [active] 758793009997 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 758793009998 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793009999 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 758793010000 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 758793010001 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 758793010002 two-component response regulator VirG; Provisional; Region: PRK13856 758793010003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793010004 active site 758793010005 phosphorylation site [posttranslational modification] 758793010006 intermolecular recognition site; other site 758793010007 dimerization interface [polypeptide binding]; other site 758793010008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793010009 DNA binding site [nucleotide binding] 758793010010 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 758793010011 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 758793010012 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 758793010013 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 758793010014 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 758793010015 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 758793010016 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 758793010017 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 758793010018 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 758793010019 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010020 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 758793010021 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010022 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010023 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010024 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010025 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010026 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 758793010027 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 758793010028 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 758793010029 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 758793010030 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 758793010031 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 758793010032 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 758793010033 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010034 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010035 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 758793010036 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 758793010037 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 758793010038 Clp amino terminal domain; Region: Clp_N; pfam02861 758793010039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793010040 Walker A motif; other site 758793010041 ATP binding site [chemical binding]; other site 758793010042 Walker B motif; other site 758793010043 arginine finger; other site 758793010044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793010045 Walker A motif; other site 758793010046 ATP binding site [chemical binding]; other site 758793010047 Walker B motif; other site 758793010048 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 758793010049 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 758793010050 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 758793010051 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 758793010052 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 758793010053 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 758793010054 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 758793010055 Protein of unknown function (DUF877); Region: DUF877; pfam05943 758793010056 Protein of unknown function (DUF770); Region: DUF770; pfam05591 758793010057 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 758793010058 anti sigma factor interaction site; other site 758793010059 regulatory phosphorylation site [posttranslational modification]; other site 758793010060 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 758793010061 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 758793010062 anti sigma factor interaction site; other site 758793010063 regulatory phosphorylation site [posttranslational modification]; other site 758793010064 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 758793010065 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 758793010066 ATP binding site [chemical binding]; other site 758793010067 Mg2+ binding site [ion binding]; other site 758793010068 G-X-G motif; other site 758793010069 Cache domain; Region: Cache_1; pfam02743 758793010070 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 758793010071 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 758793010072 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 758793010073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793010074 binding surface 758793010075 TPR motif; other site 758793010076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793010077 binding surface 758793010078 TPR motif; other site 758793010079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793010080 binding surface 758793010081 TPR motif; other site 758793010082 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 758793010083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793010084 TPR motif; other site 758793010085 binding surface 758793010086 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 758793010087 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793010088 tetramer interface [polypeptide binding]; other site 758793010089 active site 758793010090 Mg2+/Mn2+ binding site [ion binding]; other site 758793010091 isocitrate lyase; Region: PLN02892 758793010092 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 758793010093 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793010094 catalytic residue [active] 758793010095 Serine hydrolase; Region: Ser_hydrolase; pfam06821 758793010096 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793010097 BON domain; Region: BON; pfam04972 758793010098 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793010099 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793010100 trimer interface [polypeptide binding]; other site 758793010101 eyelet of channel; other site 758793010102 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 758793010103 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 758793010104 dimer interface [polypeptide binding]; other site 758793010105 acyl-activating enzyme (AAE) consensus motif; other site 758793010106 putative active site [active] 758793010107 AMP binding site [chemical binding]; other site 758793010108 putative CoA binding site [chemical binding]; other site 758793010109 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 758793010110 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 758793010111 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 758793010112 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 758793010113 NADP binding site [chemical binding]; other site 758793010114 dimer interface [polypeptide binding]; other site 758793010115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010116 putative substrate translocation pore; other site 758793010117 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 758793010118 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793010119 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 758793010120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793010121 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 758793010122 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 758793010123 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 758793010124 active site 758793010125 catalytic site [active] 758793010126 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 758793010127 homodimer interface [polypeptide binding]; other site 758793010128 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 758793010129 active site pocket [active] 758793010130 FOG: CBS domain [General function prediction only]; Region: COG0517 758793010131 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 758793010132 FOG: CBS domain [General function prediction only]; Region: COG0517 758793010133 BON domain; Region: BON; cl02771 758793010134 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793010135 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793010136 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793010137 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 758793010138 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 758793010139 putative sugar binding sites [chemical binding]; other site 758793010140 Q-X-W motif; other site 758793010141 Kelch domain; Region: Kelch; smart00612 758793010142 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 758793010143 Cytochrome c; Region: Cytochrom_C; cl11414 758793010144 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793010145 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 758793010146 substrate binding site [chemical binding]; other site 758793010147 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 758793010148 transposase; Validated; Region: PRK08181 758793010149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793010150 Walker A motif; other site 758793010151 ATP binding site [chemical binding]; other site 758793010152 Walker B motif; other site 758793010153 arginine finger; other site 758793010154 Integrase core domain; Region: rve; pfam00665 758793010155 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 758793010156 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 758793010157 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 758793010158 bacterial Hfq-like; Region: Hfq; cd01716 758793010159 hexamer interface [polypeptide binding]; other site 758793010160 Sm1 motif; other site 758793010161 RNA binding site [nucleotide binding]; other site 758793010162 Sm2 motif; other site 758793010163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793010164 active site 758793010165 phosphorylation site [posttranslational modification] 758793010166 intermolecular recognition site; other site 758793010167 dimerization interface [polypeptide binding]; other site 758793010168 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 758793010169 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 758793010170 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 758793010171 active site 758793010172 barstar interaction site; other site 758793010173 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 758793010174 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 758793010175 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 758793010176 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 758793010177 homodimer interface [polypeptide binding]; other site 758793010178 ligand binding site [chemical binding]; other site 758793010179 NAD(P) binding site [chemical binding]; other site 758793010180 trimer interface B [polypeptide binding]; other site 758793010181 trimer interface A [polypeptide binding]; other site 758793010182 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 758793010183 PAS fold; Region: PAS; pfam00989 758793010184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793010185 putative active site [active] 758793010186 heme pocket [chemical binding]; other site 758793010187 formyl-coenzyme A transferase; Provisional; Region: PRK05398 758793010188 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793010189 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 758793010190 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793010191 PYR/PP interface [polypeptide binding]; other site 758793010192 dimer interface [polypeptide binding]; other site 758793010193 TPP binding site [chemical binding]; other site 758793010194 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793010195 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 758793010196 TPP-binding site; other site 758793010197 dimer interface [polypeptide binding]; other site 758793010198 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 758793010199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010200 putative substrate translocation pore; other site 758793010201 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 758793010202 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 758793010203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793010204 active site 758793010205 phosphorylation site [posttranslational modification] 758793010206 intermolecular recognition site; other site 758793010207 dimerization interface [polypeptide binding]; other site 758793010208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793010209 DNA binding site [nucleotide binding] 758793010210 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 758793010211 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 758793010212 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 758793010213 Ligand Binding Site [chemical binding]; other site 758793010214 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 758793010215 GAF domain; Region: GAF_3; pfam13492 758793010216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793010217 dimer interface [polypeptide binding]; other site 758793010218 phosphorylation site [posttranslational modification] 758793010219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793010220 ATP binding site [chemical binding]; other site 758793010221 Mg2+ binding site [ion binding]; other site 758793010222 G-X-G motif; other site 758793010223 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 758793010224 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 758793010225 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758793010226 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 758793010227 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793010228 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793010229 Walker A/P-loop; other site 758793010230 ATP binding site [chemical binding]; other site 758793010231 Q-loop/lid; other site 758793010232 ABC transporter signature motif; other site 758793010233 Walker B; other site 758793010234 D-loop; other site 758793010235 H-loop/switch region; other site 758793010236 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793010237 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793010238 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793010239 TM-ABC transporter signature motif; other site 758793010240 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 758793010241 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793010242 putative ligand binding site [chemical binding]; other site 758793010243 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758793010244 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 758793010245 inhibitor site; inhibition site 758793010246 active site 758793010247 dimer interface [polypeptide binding]; other site 758793010248 catalytic residue [active] 758793010249 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793010250 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793010251 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 758793010252 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 758793010253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010254 D-galactonate transporter; Region: 2A0114; TIGR00893 758793010255 putative substrate translocation pore; other site 758793010256 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 758793010257 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 758793010258 putative active site pocket [active] 758793010259 putative metal binding site [ion binding]; other site 758793010260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010261 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 758793010262 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010263 dimerization interface [polypeptide binding]; other site 758793010264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010265 D-galactonate transporter; Region: 2A0114; TIGR00893 758793010266 putative substrate translocation pore; other site 758793010267 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 758793010268 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 758793010269 Na binding site [ion binding]; other site 758793010270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793010271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793010273 dimerization interface [polypeptide binding]; other site 758793010274 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 758793010275 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793010276 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 758793010277 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793010278 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793010279 DNA binding residues [nucleotide binding] 758793010280 dimerization interface [polypeptide binding]; other site 758793010281 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 758793010282 agmatinase; Region: agmatinase; TIGR01230 758793010283 oligomer interface [polypeptide binding]; other site 758793010284 putative active site [active] 758793010285 Mn binding site [ion binding]; other site 758793010286 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793010287 Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110 758793010288 NAD(P) binding site [chemical binding]; other site 758793010289 catalytic residues [active] 758793010290 catalytic residues [active] 758793010291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793010292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010293 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 758793010294 putative dimerization interface [polypeptide binding]; other site 758793010295 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 758793010296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793010297 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793010298 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793010299 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793010300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793010301 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793010302 substrate binding pocket [chemical binding]; other site 758793010303 membrane-bound complex binding site; other site 758793010304 hinge residues; other site 758793010305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 758793010306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010307 ABC-ATPase subunit interface; other site 758793010308 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758793010309 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793010310 Walker A/P-loop; other site 758793010311 ATP binding site [chemical binding]; other site 758793010312 Q-loop/lid; other site 758793010313 ABC transporter signature motif; other site 758793010314 Walker B; other site 758793010315 D-loop; other site 758793010316 H-loop/switch region; other site 758793010317 HutD; Region: HutD; pfam05962 758793010318 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 758793010319 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 758793010320 active site 758793010321 N-formylglutamate amidohydrolase; Region: FGase; cl01522 758793010322 classical (c) SDRs; Region: SDR_c; cd05233 758793010323 NAD(P) binding site [chemical binding]; other site 758793010324 active site 758793010325 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 758793010326 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 758793010327 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 758793010328 Walker A/P-loop; other site 758793010329 ATP binding site [chemical binding]; other site 758793010330 Q-loop/lid; other site 758793010331 ABC transporter signature motif; other site 758793010332 Walker B; other site 758793010333 D-loop; other site 758793010334 H-loop/switch region; other site 758793010335 TOBE domain; Region: TOBE_2; pfam08402 758793010336 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 758793010337 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 758793010338 Walker A/P-loop; other site 758793010339 ATP binding site [chemical binding]; other site 758793010340 Q-loop/lid; other site 758793010341 ABC transporter signature motif; other site 758793010342 Walker B; other site 758793010343 D-loop; other site 758793010344 H-loop/switch region; other site 758793010345 TOBE domain; Region: TOBE_2; pfam08402 758793010346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010347 dimer interface [polypeptide binding]; other site 758793010348 conserved gate region; other site 758793010349 putative PBP binding loops; other site 758793010350 ABC-ATPase subunit interface; other site 758793010351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758793010352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010353 dimer interface [polypeptide binding]; other site 758793010354 conserved gate region; other site 758793010355 putative PBP binding loops; other site 758793010356 ABC-ATPase subunit interface; other site 758793010357 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 758793010358 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 758793010359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793010360 ATP binding site [chemical binding]; other site 758793010361 putative Mg++ binding site [ion binding]; other site 758793010362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793010363 nucleotide binding region [chemical binding]; other site 758793010364 ATP-binding site [chemical binding]; other site 758793010365 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793010366 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793010367 substrate binding pocket [chemical binding]; other site 758793010368 membrane-bound complex binding site; other site 758793010369 hinge residues; other site 758793010370 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 758793010371 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793010372 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793010373 catalytic residue [active] 758793010374 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 758793010375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793010376 FeS/SAM binding site; other site 758793010377 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 758793010378 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 758793010379 Sulfatase; Region: Sulfatase; pfam00884 758793010380 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 758793010381 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 758793010382 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010383 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010384 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010385 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010386 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010387 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010388 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010389 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010390 VCBS repeat; Region: VCBS_repeat; TIGR01965 758793010391 Outer membrane efflux protein; Region: OEP; pfam02321 758793010392 Outer membrane efflux protein; Region: OEP; pfam02321 758793010393 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793010394 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793010395 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793010396 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793010397 Peptidase family M50; Region: Peptidase_M50; pfam02163 758793010398 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 758793010399 active site 758793010400 putative substrate binding region [chemical binding]; other site 758793010401 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793010402 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758793010403 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 758793010404 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 758793010405 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 758793010406 tetramer interface [polypeptide binding]; other site 758793010407 active site 758793010408 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 758793010409 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758793010410 fumarate hydratase; Reviewed; Region: fumC; PRK00485 758793010411 Class II fumarases; Region: Fumarase_classII; cd01362 758793010412 active site 758793010413 tetramer interface [polypeptide binding]; other site 758793010414 Cupin domain; Region: Cupin_2; cl17218 758793010415 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 758793010416 Beta-lactamase; Region: Beta-lactamase; pfam00144 758793010417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793010418 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793010419 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793010420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793010421 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793010422 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793010423 outer membrane lipoprotein; Provisional; Region: PRK11023 758793010424 BON domain; Region: BON; pfam04972 758793010425 hypothetical protein; Provisional; Region: PRK11667 758793010426 BON domain; Region: BON; pfam04972 758793010427 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 758793010428 LysR family transcriptional regulator; Provisional; Region: PRK14997 758793010429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010431 dimerization interface [polypeptide binding]; other site 758793010432 Isochorismatase family; Region: Isochorismatase; pfam00857 758793010433 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 758793010434 catalytic triad [active] 758793010435 conserved cis-peptide bond; other site 758793010436 choline dehydrogenase; Validated; Region: PRK02106 758793010437 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793010438 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 758793010439 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793010440 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 758793010441 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793010442 Phasin protein; Region: Phasin_2; pfam09361 758793010443 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 758793010444 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 758793010445 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 758793010446 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793010447 Walker A/P-loop; other site 758793010448 ATP binding site [chemical binding]; other site 758793010449 Q-loop/lid; other site 758793010450 ABC transporter signature motif; other site 758793010451 Walker B; other site 758793010452 D-loop; other site 758793010453 H-loop/switch region; other site 758793010454 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793010455 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 758793010456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793010457 Walker A/P-loop; other site 758793010458 ATP binding site [chemical binding]; other site 758793010459 Q-loop/lid; other site 758793010460 ABC transporter signature motif; other site 758793010461 Walker B; other site 758793010462 D-loop; other site 758793010463 H-loop/switch region; other site 758793010464 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793010465 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 758793010466 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 758793010467 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 758793010468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010469 dimer interface [polypeptide binding]; other site 758793010470 conserved gate region; other site 758793010471 putative PBP binding loops; other site 758793010472 ABC-ATPase subunit interface; other site 758793010473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758793010474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010475 dimer interface [polypeptide binding]; other site 758793010476 conserved gate region; other site 758793010477 putative PBP binding loops; other site 758793010478 ABC-ATPase subunit interface; other site 758793010479 enoyl-CoA hydratase; Provisional; Region: PRK06494 758793010480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793010481 substrate binding site [chemical binding]; other site 758793010482 oxyanion hole (OAH) forming residues; other site 758793010483 trimer interface [polypeptide binding]; other site 758793010484 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 758793010485 CoA binding domain; Region: CoA_binding_2; pfam13380 758793010486 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 758793010487 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 758793010488 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 758793010489 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793010490 substrate binding site [chemical binding]; other site 758793010491 oxyanion hole (OAH) forming residues; other site 758793010492 trimer interface [polypeptide binding]; other site 758793010493 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758793010494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793010495 Coenzyme A binding pocket [chemical binding]; other site 758793010496 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 758793010497 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 758793010498 putative ligand binding site [chemical binding]; other site 758793010499 NAD binding site [chemical binding]; other site 758793010500 dimerization interface [polypeptide binding]; other site 758793010501 catalytic site [active] 758793010502 hypothetical protein; Provisional; Region: PRK05965 758793010503 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793010504 inhibitor-cofactor binding pocket; inhibition site 758793010505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793010506 catalytic residue [active] 758793010507 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793010508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793010509 putative DNA binding site [nucleotide binding]; other site 758793010510 putative Zn2+ binding site [ion binding]; other site 758793010511 AsnC family; Region: AsnC_trans_reg; pfam01037 758793010512 tartrate dehydrogenase; Region: TTC; TIGR02089 758793010513 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 758793010514 succinic semialdehyde dehydrogenase; Region: PLN02278 758793010515 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 758793010516 tetramerization interface [polypeptide binding]; other site 758793010517 NAD(P) binding site [chemical binding]; other site 758793010518 catalytic residues [active] 758793010519 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 758793010520 putative active site [active] 758793010521 Zn binding site [ion binding]; other site 758793010522 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 758793010523 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793010524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793010525 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793010526 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793010527 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 758793010528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758793010529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793010530 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758793010531 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 758793010532 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 758793010533 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793010534 Walker A/P-loop; other site 758793010535 ATP binding site [chemical binding]; other site 758793010536 Q-loop/lid; other site 758793010537 ABC transporter signature motif; other site 758793010538 Walker B; other site 758793010539 D-loop; other site 758793010540 H-loop/switch region; other site 758793010541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793010542 Walker A/P-loop; other site 758793010543 ATP binding site [chemical binding]; other site 758793010544 Q-loop/lid; other site 758793010545 ABC transporter signature motif; other site 758793010546 Walker B; other site 758793010547 D-loop; other site 758793010548 H-loop/switch region; other site 758793010549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793010550 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 758793010551 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 758793010552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010553 dimer interface [polypeptide binding]; other site 758793010554 conserved gate region; other site 758793010555 ABC-ATPase subunit interface; other site 758793010556 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 758793010557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010558 dimer interface [polypeptide binding]; other site 758793010559 conserved gate region; other site 758793010560 putative PBP binding loops; other site 758793010561 ABC-ATPase subunit interface; other site 758793010562 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793010563 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 758793010564 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 758793010565 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793010566 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 758793010567 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793010568 motif II; other site 758793010569 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793010570 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793010571 NAD(P) binding site [chemical binding]; other site 758793010572 catalytic residues [active] 758793010573 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 758793010574 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793010575 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 758793010576 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 758793010577 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 758793010578 putative active site [active] 758793010579 putative FMN binding site [chemical binding]; other site 758793010580 putative catalytic residue [active] 758793010581 putative substrate binding site [chemical binding]; other site 758793010582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793010583 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793010584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010586 dimerization interface [polypeptide binding]; other site 758793010587 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 758793010588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010590 dimerization interface [polypeptide binding]; other site 758793010591 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 758793010592 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 758793010593 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793010594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793010595 Walker A/P-loop; other site 758793010596 ATP binding site [chemical binding]; other site 758793010597 Q-loop/lid; other site 758793010598 ABC transporter signature motif; other site 758793010599 Walker B; other site 758793010600 D-loop; other site 758793010601 H-loop/switch region; other site 758793010602 TOBE domain; Region: TOBE_2; pfam08402 758793010603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010604 dimer interface [polypeptide binding]; other site 758793010605 conserved gate region; other site 758793010606 putative PBP binding loops; other site 758793010607 ABC-ATPase subunit interface; other site 758793010608 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793010609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010610 dimer interface [polypeptide binding]; other site 758793010611 conserved gate region; other site 758793010612 putative PBP binding loops; other site 758793010613 ABC-ATPase subunit interface; other site 758793010614 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793010615 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793010616 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 758793010617 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758793010618 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793010619 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793010620 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 758793010621 homotrimer interaction site [polypeptide binding]; other site 758793010622 putative active site [active] 758793010623 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793010624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010625 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793010626 dimerization interface [polypeptide binding]; other site 758793010627 substrate binding pocket [chemical binding]; other site 758793010628 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 758793010629 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 758793010630 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 758793010631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010632 putative substrate translocation pore; other site 758793010633 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 758793010634 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 758793010635 active site 758793010636 non-prolyl cis peptide bond; other site 758793010637 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 758793010638 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 758793010639 catalytic residues [active] 758793010640 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 758793010641 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793010642 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793010643 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 758793010644 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793010645 acyl-activating enzyme (AAE) consensus motif; other site 758793010646 AMP binding site [chemical binding]; other site 758793010647 active site 758793010648 CoA binding site [chemical binding]; other site 758793010649 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 758793010650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010651 dimer interface [polypeptide binding]; other site 758793010652 conserved gate region; other site 758793010653 putative PBP binding loops; other site 758793010654 ABC-ATPase subunit interface; other site 758793010655 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793010656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010657 dimer interface [polypeptide binding]; other site 758793010658 conserved gate region; other site 758793010659 putative PBP binding loops; other site 758793010660 ABC-ATPase subunit interface; other site 758793010661 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793010662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793010663 Walker A/P-loop; other site 758793010664 ATP binding site [chemical binding]; other site 758793010665 Q-loop/lid; other site 758793010666 ABC transporter signature motif; other site 758793010667 Walker B; other site 758793010668 D-loop; other site 758793010669 H-loop/switch region; other site 758793010670 TOBE domain; Region: TOBE_2; pfam08402 758793010671 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 758793010672 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758793010673 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 758793010674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793010675 substrate binding site [chemical binding]; other site 758793010676 oxyanion hole (OAH) forming residues; other site 758793010677 trimer interface [polypeptide binding]; other site 758793010678 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793010679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793010680 DNA-binding site [nucleotide binding]; DNA binding site 758793010681 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 758793010682 FCD domain; Region: FCD; pfam07729 758793010683 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 758793010684 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 758793010685 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 758793010686 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 758793010687 NAD binding site [chemical binding]; other site 758793010688 catalytic Zn binding site [ion binding]; other site 758793010689 substrate binding site [chemical binding]; other site 758793010690 structural Zn binding site [ion binding]; other site 758793010691 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 758793010692 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 758793010693 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 758793010694 phosphate binding site [ion binding]; other site 758793010695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010696 D-galactonate transporter; Region: 2A0114; TIGR00893 758793010697 putative substrate translocation pore; other site 758793010698 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 758793010699 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793010700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793010701 Walker A/P-loop; other site 758793010702 ATP binding site [chemical binding]; other site 758793010703 Q-loop/lid; other site 758793010704 ABC transporter signature motif; other site 758793010705 Walker B; other site 758793010706 D-loop; other site 758793010707 H-loop/switch region; other site 758793010708 TOBE domain; Region: TOBE_2; pfam08402 758793010709 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793010710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010711 dimer interface [polypeptide binding]; other site 758793010712 conserved gate region; other site 758793010713 putative PBP binding loops; other site 758793010714 ABC-ATPase subunit interface; other site 758793010715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010716 putative PBP binding loops; other site 758793010717 dimer interface [polypeptide binding]; other site 758793010718 ABC-ATPase subunit interface; other site 758793010719 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758793010720 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 758793010721 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 758793010722 RibD C-terminal domain; Region: RibD_C; cl17279 758793010723 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 758793010724 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 758793010725 PhoU domain; Region: PhoU; pfam01895 758793010726 circadian clock protein KaiC; Reviewed; Region: PRK09302 758793010727 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793010728 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793010729 Walker A motif; other site 758793010730 Walker A motif; other site 758793010731 ATP binding site [chemical binding]; other site 758793010732 Walker B motif; other site 758793010733 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793010734 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793010735 Walker A motif; other site 758793010736 Walker A motif; other site 758793010737 ATP binding site [chemical binding]; other site 758793010738 Walker B motif; other site 758793010739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793010740 dimer interface [polypeptide binding]; other site 758793010741 phosphorylation site [posttranslational modification] 758793010742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793010743 ATP binding site [chemical binding]; other site 758793010744 Mg2+ binding site [ion binding]; other site 758793010745 G-X-G motif; other site 758793010746 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793010747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793010748 active site 758793010749 phosphorylation site [posttranslational modification] 758793010750 intermolecular recognition site; other site 758793010751 dimerization interface [polypeptide binding]; other site 758793010752 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758793010753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758793010754 non-specific DNA binding site [nucleotide binding]; other site 758793010755 salt bridge; other site 758793010756 sequence-specific DNA binding site [nucleotide binding]; other site 758793010757 Uncharacterized conserved protein [Function unknown]; Region: COG2128 758793010758 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 758793010759 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 758793010760 trimer interface [polypeptide binding]; other site 758793010761 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 758793010762 trimer interface [polypeptide binding]; other site 758793010763 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 758793010764 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 758793010765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010766 putative substrate translocation pore; other site 758793010767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010768 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 758793010769 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793010770 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793010771 MarR family; Region: MarR_2; cl17246 758793010772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793010773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 758793010774 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 758793010775 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 758793010776 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793010777 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793010778 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793010779 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793010780 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793010781 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793010782 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793010783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010784 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010785 dimerization interface [polypeptide binding]; other site 758793010786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010787 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010788 dimerization interface [polypeptide binding]; other site 758793010789 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 758793010790 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 758793010791 active site 758793010792 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 758793010793 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 758793010794 Flavoprotein; Region: Flavoprotein; pfam02441 758793010795 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 758793010796 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 758793010797 P-loop, Walker A motif; other site 758793010798 Base recognition motif; other site 758793010799 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 758793010800 xanthine permease; Region: pbuX; TIGR03173 758793010801 amidohydrolase; Provisional; Region: PRK12393 758793010802 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 758793010803 active site 758793010804 putative substrate binding pocket [chemical binding]; other site 758793010805 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 758793010806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793010807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010808 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010809 dimerization interface [polypeptide binding]; other site 758793010810 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793010811 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 758793010812 C-terminal domain interface [polypeptide binding]; other site 758793010813 GSH binding site (G-site) [chemical binding]; other site 758793010814 dimer interface [polypeptide binding]; other site 758793010815 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 758793010816 N-terminal domain interface [polypeptide binding]; other site 758793010817 dimer interface [polypeptide binding]; other site 758793010818 substrate binding pocket (H-site) [chemical binding]; other site 758793010819 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 758793010820 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 758793010821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793010822 Walker A motif; other site 758793010823 ATP binding site [chemical binding]; other site 758793010824 Walker B motif; other site 758793010825 arginine finger; other site 758793010826 Peptidase family M41; Region: Peptidase_M41; pfam01434 758793010827 Cache domain; Region: Cache_1; pfam02743 758793010828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793010829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793010830 metal binding site [ion binding]; metal-binding site 758793010831 active site 758793010832 I-site; other site 758793010833 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 758793010834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793010835 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 758793010836 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 758793010837 active site 758793010838 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 758793010839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793010840 active site 758793010841 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793010842 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 758793010843 substrate binding site [chemical binding]; other site 758793010844 oxyanion hole (OAH) forming residues; other site 758793010845 trimer interface [polypeptide binding]; other site 758793010846 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793010847 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793010848 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793010849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793010850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010851 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793010852 putative effector binding pocket; other site 758793010853 dimerization interface [polypeptide binding]; other site 758793010854 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758793010855 EamA-like transporter family; Region: EamA; pfam00892 758793010856 EamA-like transporter family; Region: EamA; pfam00892 758793010857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793010858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793010860 dimerization interface [polypeptide binding]; other site 758793010861 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 758793010862 homotrimer interaction site [polypeptide binding]; other site 758793010863 putative active site [active] 758793010864 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 758793010865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793010866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793010867 ATP binding site [chemical binding]; other site 758793010868 Mg2+ binding site [ion binding]; other site 758793010869 G-X-G motif; other site 758793010870 Response regulator receiver domain; Region: Response_reg; pfam00072 758793010871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793010872 active site 758793010873 phosphorylation site [posttranslational modification] 758793010874 intermolecular recognition site; other site 758793010875 dimerization interface [polypeptide binding]; other site 758793010876 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 758793010877 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793010878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793010879 DNA-binding site [nucleotide binding]; DNA binding site 758793010880 FCD domain; Region: FCD; pfam07729 758793010881 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 758793010882 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 758793010883 putative active site [active] 758793010884 putative catalytic site [active] 758793010885 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793010886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793010887 Walker A/P-loop; other site 758793010888 ATP binding site [chemical binding]; other site 758793010889 Q-loop/lid; other site 758793010890 ABC transporter signature motif; other site 758793010891 Walker B; other site 758793010892 D-loop; other site 758793010893 H-loop/switch region; other site 758793010894 TOBE domain; Region: TOBE_2; pfam08402 758793010895 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758793010896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758793010897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010898 dimer interface [polypeptide binding]; other site 758793010899 conserved gate region; other site 758793010900 putative PBP binding loops; other site 758793010901 ABC-ATPase subunit interface; other site 758793010902 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793010903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793010904 dimer interface [polypeptide binding]; other site 758793010905 conserved gate region; other site 758793010906 putative PBP binding loops; other site 758793010907 ABC-ATPase subunit interface; other site 758793010908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793010909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793010910 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793010911 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 758793010912 TM-ABC transporter signature motif; other site 758793010913 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793010914 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 758793010915 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 758793010916 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 758793010917 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793010918 Walker A/P-loop; other site 758793010919 ATP binding site [chemical binding]; other site 758793010920 Q-loop/lid; other site 758793010921 ABC transporter signature motif; other site 758793010922 Walker B; other site 758793010923 D-loop; other site 758793010924 H-loop/switch region; other site 758793010925 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793010926 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 758793010927 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 758793010928 ligand binding site [chemical binding]; other site 758793010929 Isochorismatase family; Region: Isochorismatase; pfam00857 758793010930 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 758793010931 catalytic triad [active] 758793010932 conserved cis-peptide bond; other site 758793010933 indole-3-acetamide amidohydrolase; Region: PLN02722 758793010934 Amidase; Region: Amidase; cl11426 758793010935 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 758793010936 amidase; Provisional; Region: PRK09201 758793010937 Amidase; Region: Amidase; cl11426 758793010938 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 758793010939 SnoaL-like domain; Region: SnoaL_3; pfam13474 758793010940 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 758793010941 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793010942 NAD binding site [chemical binding]; other site 758793010943 catalytic residues [active] 758793010944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793010945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793010946 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 758793010947 putative effector binding pocket; other site 758793010948 putative dimerization interface [polypeptide binding]; other site 758793010949 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793010950 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793010951 trimer interface [polypeptide binding]; other site 758793010952 eyelet of channel; other site 758793010953 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 758793010954 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793010955 putative ligand binding site [chemical binding]; other site 758793010956 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793010957 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793010958 Walker A/P-loop; other site 758793010959 ATP binding site [chemical binding]; other site 758793010960 Q-loop/lid; other site 758793010961 ABC transporter signature motif; other site 758793010962 Walker B; other site 758793010963 D-loop; other site 758793010964 H-loop/switch region; other site 758793010965 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793010966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793010967 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793010968 TM-ABC transporter signature motif; other site 758793010969 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793010970 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793010971 TM-ABC transporter signature motif; other site 758793010972 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793010973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793010974 DNA-binding site [nucleotide binding]; DNA binding site 758793010975 FCD domain; Region: FCD; pfam07729 758793010976 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 758793010977 allantoate amidohydrolase; Reviewed; Region: PRK12893 758793010978 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 758793010979 active site 758793010980 metal binding site [ion binding]; metal-binding site 758793010981 dimer interface [polypeptide binding]; other site 758793010982 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793010983 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 758793010984 aspartate aminotransferase; Provisional; Region: PRK06225 758793010985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793010986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793010987 homodimer interface [polypeptide binding]; other site 758793010988 catalytic residue [active] 758793010989 short chain dehydrogenase; Provisional; Region: PRK06125 758793010990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793010991 NAD(P) binding site [chemical binding]; other site 758793010992 active site 758793010993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793010994 D-galactonate transporter; Region: 2A0114; TIGR00893 758793010995 putative substrate translocation pore; other site 758793010996 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793010997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793010998 DNA-binding site [nucleotide binding]; DNA binding site 758793010999 FCD domain; Region: FCD; pfam07729 758793011000 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 758793011001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793011003 dimerization interface [polypeptide binding]; other site 758793011004 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 758793011005 aspartate racemase; Region: asp_race; TIGR00035 758793011006 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 758793011007 dihydropyrimidinase; Provisional; Region: PRK13404 758793011008 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 758793011009 tetramer interface [polypeptide binding]; other site 758793011010 active site 758793011011 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 758793011012 tetramer interface [polypeptide binding]; other site 758793011013 Predicted amidohydrolase [General function prediction only]; Region: COG0388 758793011014 active site 758793011015 catalytic triad [active] 758793011016 dimer interface [polypeptide binding]; other site 758793011017 benzoate transport; Region: 2A0115; TIGR00895 758793011018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011019 putative substrate translocation pore; other site 758793011020 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 758793011021 conserved cys residue [active] 758793011022 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793011023 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 758793011024 catalytic residue [active] 758793011025 PAAR motif; Region: PAAR_motif; pfam05488 758793011026 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 758793011027 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 758793011028 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 758793011029 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 758793011030 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 758793011031 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 758793011032 dimer interface [polypeptide binding]; other site 758793011033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793011034 catalytic residue [active] 758793011035 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 758793011036 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 758793011037 nudix motif; other site 758793011038 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 758793011039 putative deacylase active site [active] 758793011040 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 758793011041 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 758793011042 putative NAD(P) binding site [chemical binding]; other site 758793011043 putative substrate binding site [chemical binding]; other site 758793011044 catalytic Zn binding site [ion binding]; other site 758793011045 structural Zn binding site [ion binding]; other site 758793011046 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793011047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793011048 dimerization interface [polypeptide binding]; other site 758793011049 putative DNA binding site [nucleotide binding]; other site 758793011050 putative Zn2+ binding site [ion binding]; other site 758793011051 AsnC family; Region: AsnC_trans_reg; pfam01037 758793011052 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 758793011053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793011054 motif II; other site 758793011055 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 758793011056 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 758793011057 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793011058 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 758793011059 dimerization interface [polypeptide binding]; other site 758793011060 ligand binding site [chemical binding]; other site 758793011061 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 758793011062 Proline racemase; Region: Pro_racemase; pfam05544 758793011063 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793011064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011065 DNA-binding site [nucleotide binding]; DNA binding site 758793011066 FCD domain; Region: FCD; pfam07729 758793011067 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 758793011068 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 758793011069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011070 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793011071 dimerization interface [polypeptide binding]; other site 758793011072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011073 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793011074 putative substrate translocation pore; other site 758793011075 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793011076 classical (c) SDRs; Region: SDR_c; cd05233 758793011077 NAD(P) binding site [chemical binding]; other site 758793011078 active site 758793011079 Epoxide hydrolase N terminus; Region: EHN; pfam06441 758793011080 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793011081 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793011082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011083 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793011084 dimerization interface [polypeptide binding]; other site 758793011085 substrate binding pocket [chemical binding]; other site 758793011086 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 758793011087 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793011088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011089 putative substrate translocation pore; other site 758793011090 putative MFS family transporter protein; Provisional; Region: PRK03633 758793011091 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 758793011092 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 758793011093 CHASE2 domain; Region: CHASE2; cl01732 758793011094 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 758793011095 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 758793011096 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 758793011097 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 758793011098 acetylornithine deacetylase; Provisional; Region: PRK07522 758793011099 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 758793011100 metal binding site [ion binding]; metal-binding site 758793011101 putative dimer interface [polypeptide binding]; other site 758793011102 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 758793011103 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758793011104 homotrimer interaction site [polypeptide binding]; other site 758793011105 putative active site [active] 758793011106 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 758793011107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793011108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793011109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011110 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 758793011111 putative substrate binding pocket [chemical binding]; other site 758793011112 dimerization interface [polypeptide binding]; other site 758793011113 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793011114 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 758793011115 [2Fe-2S] cluster binding site [ion binding]; other site 758793011116 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 758793011117 putative alpha subunit interface [polypeptide binding]; other site 758793011118 putative active site [active] 758793011119 putative substrate binding site [chemical binding]; other site 758793011120 Fe binding site [ion binding]; other site 758793011121 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793011122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793011123 Walker A/P-loop; other site 758793011124 ATP binding site [chemical binding]; other site 758793011125 Q-loop/lid; other site 758793011126 ABC transporter signature motif; other site 758793011127 Walker B; other site 758793011128 D-loop; other site 758793011129 H-loop/switch region; other site 758793011130 TOBE domain; Region: TOBE_2; pfam08402 758793011131 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758793011132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793011133 dimer interface [polypeptide binding]; other site 758793011134 conserved gate region; other site 758793011135 putative PBP binding loops; other site 758793011136 ABC-ATPase subunit interface; other site 758793011137 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793011138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793011139 conserved gate region; other site 758793011140 dimer interface [polypeptide binding]; other site 758793011141 putative PBP binding loops; other site 758793011142 ABC-ATPase subunit interface; other site 758793011143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 758793011144 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793011145 ligand binding site [chemical binding]; other site 758793011146 flexible hinge region; other site 758793011147 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 758793011148 non-specific DNA interactions [nucleotide binding]; other site 758793011149 DNA binding site [nucleotide binding] 758793011150 sequence specific DNA binding site [nucleotide binding]; other site 758793011151 putative cAMP binding site [chemical binding]; other site 758793011152 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 758793011153 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 758793011154 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 758793011155 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 758793011156 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 758793011157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793011158 catalytic residue [active] 758793011159 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793011160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793011161 putative DNA binding site [nucleotide binding]; other site 758793011162 putative Zn2+ binding site [ion binding]; other site 758793011163 AsnC family; Region: AsnC_trans_reg; pfam01037 758793011164 Transglycosylase; Region: Transgly; pfam00912 758793011165 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 758793011166 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 758793011167 hypothetical protein; Validated; Region: PRK08238 758793011168 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 758793011169 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 758793011170 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 758793011171 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793011172 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 758793011173 conserved cys residue [active] 758793011174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793011175 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 758793011176 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 758793011177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793011178 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 758793011179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793011180 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 758793011181 putative ADP-binding pocket [chemical binding]; other site 758793011182 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 758793011183 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 758793011184 putative ADP-binding pocket [chemical binding]; other site 758793011185 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 758793011186 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 758793011187 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 758793011188 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793011189 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 758793011190 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 758793011191 Mg++ binding site [ion binding]; other site 758793011192 putative catalytic motif [active] 758793011193 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 758793011194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793011195 putative ADP-binding pocket [chemical binding]; other site 758793011196 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793011197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793011198 active site 758793011199 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 758793011200 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 758793011201 nudix motif; other site 758793011202 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 758793011203 Phosphoesterase family; Region: Phosphoesterase; pfam04185 758793011204 Domain of unknown function (DUF756); Region: DUF756; pfam05506 758793011205 Domain of unknown function (DUF756); Region: DUF756; pfam05506 758793011206 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 758793011207 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793011208 P-loop; other site 758793011209 Magnesium ion binding site [ion binding]; other site 758793011210 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793011211 Magnesium ion binding site [ion binding]; other site 758793011212 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 758793011213 ParB-like nuclease domain; Region: ParBc; pfam02195 758793011214 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 758793011215 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 758793011216 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 758793011217 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 758793011218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793011219 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758793011220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793011221 DNA binding residues [nucleotide binding] 758793011222 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 758793011223 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 758793011224 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793011225 dimer interface [polypeptide binding]; other site 758793011226 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 758793011227 putative CheW interface [polypeptide binding]; other site 758793011228 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793011229 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 758793011230 C-terminal domain interface [polypeptide binding]; other site 758793011231 GSH binding site (G-site) [chemical binding]; other site 758793011232 dimer interface [polypeptide binding]; other site 758793011233 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 758793011234 dimer interface [polypeptide binding]; other site 758793011235 N-terminal domain interface [polypeptide binding]; other site 758793011236 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 758793011237 classical (c) SDRs; Region: SDR_c; cd05233 758793011238 NAD(P) binding site [chemical binding]; other site 758793011239 active site 758793011240 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 758793011241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793011242 Walker A motif; other site 758793011243 ATP binding site [chemical binding]; other site 758793011244 Walker B motif; other site 758793011245 arginine finger; other site 758793011246 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793011247 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 758793011248 ATP-NAD kinase; Region: NAD_kinase; pfam01513 758793011249 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 758793011250 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 758793011251 tetramer interface [polypeptide binding]; other site 758793011252 TPP-binding site [chemical binding]; other site 758793011253 heterodimer interface [polypeptide binding]; other site 758793011254 phosphorylation loop region [posttranslational modification] 758793011255 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 758793011256 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 758793011257 alpha subunit interface [polypeptide binding]; other site 758793011258 TPP binding site [chemical binding]; other site 758793011259 heterodimer interface [polypeptide binding]; other site 758793011260 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793011261 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 758793011262 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793011263 E3 interaction surface; other site 758793011264 lipoyl attachment site [posttranslational modification]; other site 758793011265 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 758793011266 catalytic site [active] 758793011267 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 758793011268 Class I aldolases; Region: Aldolase_Class_I; cl17187 758793011269 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 758793011270 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758793011271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011272 DNA-binding site [nucleotide binding]; DNA binding site 758793011273 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758793011274 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 758793011275 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 758793011276 dimer interface [polypeptide binding]; other site 758793011277 ADP-ribose binding site [chemical binding]; other site 758793011278 active site 758793011279 nudix motif; other site 758793011280 metal binding site [ion binding]; metal-binding site 758793011281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793011282 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 758793011283 Walker A/P-loop; other site 758793011284 ATP binding site [chemical binding]; other site 758793011285 Q-loop/lid; other site 758793011286 ABC transporter signature motif; other site 758793011287 Walker B; other site 758793011288 D-loop; other site 758793011289 H-loop/switch region; other site 758793011290 TOBE domain; Region: TOBE; cl01440 758793011291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793011292 dimer interface [polypeptide binding]; other site 758793011293 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 758793011294 conserved gate region; other site 758793011295 putative PBP binding loops; other site 758793011296 ABC-ATPase subunit interface; other site 758793011297 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 758793011298 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 758793011299 enoyl-CoA hydratase; Provisional; Region: PRK05995 758793011300 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793011301 substrate binding site [chemical binding]; other site 758793011302 oxyanion hole (OAH) forming residues; other site 758793011303 trimer interface [polypeptide binding]; other site 758793011304 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793011305 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 758793011306 putative C-terminal domain interface [polypeptide binding]; other site 758793011307 putative GSH binding site (G-site) [chemical binding]; other site 758793011308 putative dimer interface [polypeptide binding]; other site 758793011309 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793011310 N-terminal domain interface [polypeptide binding]; other site 758793011311 dimer interface [polypeptide binding]; other site 758793011312 substrate binding pocket (H-site) [chemical binding]; other site 758793011313 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 758793011314 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 758793011315 Cytochrome c553 [Energy production and conversion]; Region: COG2863 758793011316 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 758793011317 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 758793011318 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 758793011319 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 758793011320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 758793011321 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 758793011322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793011323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011324 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 758793011325 dimerization interface [polypeptide binding]; other site 758793011326 substrate binding pocket [chemical binding]; other site 758793011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011328 D-galactonate transporter; Region: 2A0114; TIGR00893 758793011329 putative substrate translocation pore; other site 758793011330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011331 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 758793011332 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 758793011333 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 758793011334 DctM-like transporters; Region: DctM; pfam06808 758793011335 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 758793011336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793011337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793011338 DNA binding site [nucleotide binding] 758793011339 domain linker motif; other site 758793011340 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 758793011341 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 758793011342 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 758793011343 putative ligand binding site [chemical binding]; other site 758793011344 putative NAD binding site [chemical binding]; other site 758793011345 catalytic site [active] 758793011346 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793011347 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 758793011348 active site 758793011349 short chain dehydrogenase; Provisional; Region: PRK12828 758793011350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793011351 NAD(P) binding site [chemical binding]; other site 758793011352 active site 758793011353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793011354 PAS fold; Region: PAS_3; pfam08447 758793011355 putative active site [active] 758793011356 heme pocket [chemical binding]; other site 758793011357 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793011358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793011359 metal binding site [ion binding]; metal-binding site 758793011360 active site 758793011361 I-site; other site 758793011362 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 758793011363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793011364 S-adenosylmethionine binding site [chemical binding]; other site 758793011365 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 758793011366 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 758793011367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793011368 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793011369 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 758793011370 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 758793011371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793011372 S-adenosylmethionine binding site [chemical binding]; other site 758793011373 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 758793011374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 758793011375 Anti-sigma-K factor rskA; Region: RskA; pfam10099 758793011376 RNA polymerase sigma factor; Provisional; Region: PRK12534 758793011377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793011378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793011379 DNA binding residues [nucleotide binding] 758793011380 SET domain; Region: SET; pfam00856 758793011381 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793011382 FAD binding domain; Region: FAD_binding_4; pfam01565 758793011383 Cupin domain; Region: Cupin_2; cl17218 758793011384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793011385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011386 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 758793011387 putative dimerization interface [polypeptide binding]; other site 758793011388 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 758793011389 active site 758793011390 catalytic residues [active] 758793011391 metal binding site [ion binding]; metal-binding site 758793011392 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793011393 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793011394 benzoate transport; Region: 2A0115; TIGR00895 758793011395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011397 putative substrate translocation pore; other site 758793011398 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 758793011399 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793011400 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793011401 trimer interface [polypeptide binding]; other site 758793011402 eyelet of channel; other site 758793011403 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 758793011404 GAF domain; Region: GAF; pfam01590 758793011405 Phytochrome region; Region: PHY; pfam00360 758793011406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793011407 dimer interface [polypeptide binding]; other site 758793011408 phosphorylation site [posttranslational modification] 758793011409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793011410 ATP binding site [chemical binding]; other site 758793011411 Mg2+ binding site [ion binding]; other site 758793011412 G-X-G motif; other site 758793011413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 758793011414 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 758793011415 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793011416 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793011417 trimer interface [polypeptide binding]; other site 758793011418 eyelet of channel; other site 758793011419 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 758793011420 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793011421 NAD binding site [chemical binding]; other site 758793011422 catalytic residues [active] 758793011423 substrate binding site [chemical binding]; other site 758793011424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793011426 putative substrate translocation pore; other site 758793011427 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 758793011428 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 758793011429 active site pocket [active] 758793011430 choline dehydrogenase; Validated; Region: PRK02106 758793011431 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793011432 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793011433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011434 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793011435 dimerization interface [polypeptide binding]; other site 758793011436 substrate binding pocket [chemical binding]; other site 758793011437 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793011438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793011440 dimerization interface [polypeptide binding]; other site 758793011441 benzoate transport; Region: 2A0115; TIGR00895 758793011442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011443 putative substrate translocation pore; other site 758793011444 succinic semialdehyde dehydrogenase; Region: PLN02278 758793011445 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 758793011446 tetramerization interface [polypeptide binding]; other site 758793011447 NAD(P) binding site [chemical binding]; other site 758793011448 catalytic residues [active] 758793011449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793011450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793011451 active site 758793011452 catalytic tetrad [active] 758793011453 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 758793011454 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 758793011455 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 758793011456 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 758793011457 active site 758793011458 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 758793011459 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793011460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793011461 dimer interface [polypeptide binding]; other site 758793011462 conserved gate region; other site 758793011463 putative PBP binding loops; other site 758793011464 ABC-ATPase subunit interface; other site 758793011465 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793011466 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793011467 Walker A/P-loop; other site 758793011468 ATP binding site [chemical binding]; other site 758793011469 Q-loop/lid; other site 758793011470 ABC transporter signature motif; other site 758793011471 Walker B; other site 758793011472 D-loop; other site 758793011473 H-loop/switch region; other site 758793011474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 758793011475 NMT1/THI5 like; Region: NMT1; pfam09084 758793011476 membrane-bound complex binding site; other site 758793011477 hinge residues; other site 758793011478 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 758793011479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793011480 active site 758793011481 phosphorylation site [posttranslational modification] 758793011482 intermolecular recognition site; other site 758793011483 dimerization interface [polypeptide binding]; other site 758793011484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793011485 DNA binding site [nucleotide binding] 758793011486 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 758793011487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793011488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793011489 dimer interface [polypeptide binding]; other site 758793011490 phosphorylation site [posttranslational modification] 758793011491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793011492 ATP binding site [chemical binding]; other site 758793011493 Mg2+ binding site [ion binding]; other site 758793011494 G-X-G motif; other site 758793011495 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 758793011496 active site 758793011497 PQQ-like domain; Region: PQQ_2; pfam13360 758793011498 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 758793011499 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 758793011500 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 758793011501 active site turn [active] 758793011502 phosphorylation site [posttranslational modification] 758793011503 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 758793011504 active site turn [active] 758793011505 phosphorylation site [posttranslational modification] 758793011506 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 758793011507 HPr interaction site; other site 758793011508 glycerol kinase (GK) interaction site [polypeptide binding]; other site 758793011509 active site 758793011510 phosphorylation site [posttranslational modification] 758793011511 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 758793011512 dimerization domain swap beta strand [polypeptide binding]; other site 758793011513 regulatory protein interface [polypeptide binding]; other site 758793011514 active site 758793011515 regulatory phosphorylation site [posttranslational modification]; other site 758793011516 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 758793011517 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 758793011518 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 758793011519 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 758793011520 TPR repeat; Region: TPR_11; pfam13414 758793011521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793011522 TPR motif; other site 758793011523 binding surface 758793011524 TPR repeat; Region: TPR_11; pfam13414 758793011525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793011526 TPR motif; other site 758793011527 binding surface 758793011528 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793011529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011530 putative substrate translocation pore; other site 758793011531 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 758793011532 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758793011533 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 758793011534 inhibitor site; inhibition site 758793011535 active site 758793011536 dimer interface [polypeptide binding]; other site 758793011537 catalytic residue [active] 758793011538 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 758793011539 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 758793011540 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 758793011541 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758793011542 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 758793011543 active site 758793011544 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793011545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011546 DNA-binding site [nucleotide binding]; DNA binding site 758793011547 FCD domain; Region: FCD; pfam07729 758793011548 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 758793011549 substrate binding site [chemical binding]; other site 758793011550 Protein of unknown function (DUF521); Region: DUF521; pfam04412 758793011551 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 758793011552 substrate binding site [chemical binding]; other site 758793011553 ligand binding site [chemical binding]; other site 758793011554 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 758793011555 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758793011556 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 758793011557 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 758793011558 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758793011559 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 758793011560 Uncharacterized conserved protein [Function unknown]; Region: COG2128 758793011561 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793011562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011563 DNA-binding site [nucleotide binding]; DNA binding site 758793011564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793011565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793011566 homodimer interface [polypeptide binding]; other site 758793011567 catalytic residue [active] 758793011568 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793011569 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793011570 trimer interface [polypeptide binding]; other site 758793011571 eyelet of channel; other site 758793011572 BON domain; Region: BON; pfam04972 758793011573 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 758793011574 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 758793011575 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 758793011576 dimer interface [polypeptide binding]; other site 758793011577 active site 758793011578 heme binding site [chemical binding]; other site 758793011579 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 758793011580 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793011581 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 758793011582 tetramer interface [polypeptide binding]; other site 758793011583 active site 758793011584 Mg2+/Mn2+ binding site [ion binding]; other site 758793011585 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758793011586 homotrimer interaction site [polypeptide binding]; other site 758793011587 putative active site [active] 758793011588 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 758793011589 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793011590 tetramer interface [polypeptide binding]; other site 758793011591 active site 758793011592 Mg2+/Mn2+ binding site [ion binding]; other site 758793011593 benzoate transport; Region: 2A0115; TIGR00895 758793011594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011595 putative substrate translocation pore; other site 758793011596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011597 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793011598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011599 DNA-binding site [nucleotide binding]; DNA binding site 758793011600 FCD domain; Region: FCD; pfam07729 758793011601 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793011602 Cytochrome c; Region: Cytochrom_C; pfam00034 758793011603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793011604 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793011605 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793011606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011607 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793011608 putative substrate translocation pore; other site 758793011609 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 758793011610 Dehydroquinase class II; Region: DHquinase_II; pfam01220 758793011611 trimer interface [polypeptide binding]; other site 758793011612 active site 758793011613 dimer interface [polypeptide binding]; other site 758793011614 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 758793011615 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 758793011616 active site 758793011617 acyl-activating enzyme (AAE) consensus motif; other site 758793011618 putative CoA binding site [chemical binding]; other site 758793011619 AMP binding site [chemical binding]; other site 758793011620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011621 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793011622 putative substrate translocation pore; other site 758793011623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011624 putative substrate translocation pore; other site 758793011625 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 758793011626 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 758793011627 DNA binding residues [nucleotide binding] 758793011628 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 758793011629 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 758793011630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793011631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011632 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793011633 putative effector binding pocket; other site 758793011634 dimerization interface [polypeptide binding]; other site 758793011635 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 758793011636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011637 putative substrate translocation pore; other site 758793011638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793011639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011640 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793011641 putative effector binding pocket; other site 758793011642 dimerization interface [polypeptide binding]; other site 758793011643 Response regulator receiver domain; Region: Response_reg; pfam00072 758793011644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793011645 active site 758793011646 phosphorylation site [posttranslational modification] 758793011647 intermolecular recognition site; other site 758793011648 dimerization interface [polypeptide binding]; other site 758793011649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793011650 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 758793011651 putative active site [active] 758793011652 heme pocket [chemical binding]; other site 758793011653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793011654 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 758793011655 putative active site [active] 758793011656 heme pocket [chemical binding]; other site 758793011657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 758793011658 putative active site [active] 758793011659 heme pocket [chemical binding]; other site 758793011660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793011661 dimer interface [polypeptide binding]; other site 758793011662 phosphorylation site [posttranslational modification] 758793011663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793011664 ATP binding site [chemical binding]; other site 758793011665 Mg2+ binding site [ion binding]; other site 758793011666 G-X-G motif; other site 758793011667 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 758793011668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793011669 active site 758793011670 phosphorylation site [posttranslational modification] 758793011671 intermolecular recognition site; other site 758793011672 dimerization interface [polypeptide binding]; other site 758793011673 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793011674 DNA binding residues [nucleotide binding] 758793011675 dimerization interface [polypeptide binding]; other site 758793011676 PAS domain; Region: PAS; smart00091 758793011677 PAS fold; Region: PAS_7; pfam12860 758793011678 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793011679 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793011680 metal binding site [ion binding]; metal-binding site 758793011681 active site 758793011682 I-site; other site 758793011683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011684 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793011685 putative substrate translocation pore; other site 758793011686 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793011687 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793011688 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793011689 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 758793011690 Dehydroquinase class II; Region: DHquinase_II; pfam01220 758793011691 trimer interface [polypeptide binding]; other site 758793011692 active site 758793011693 dimer interface [polypeptide binding]; other site 758793011694 aromatic amino acid transporter; Provisional; Region: PRK10238 758793011695 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 758793011696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793011697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793011698 homodimer interface [polypeptide binding]; other site 758793011699 catalytic residue [active] 758793011700 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 758793011701 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 758793011702 Trp docking motif [polypeptide binding]; other site 758793011703 putative active site [active] 758793011704 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 758793011705 PQQ-like domain; Region: PQQ_2; pfam13360 758793011706 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 758793011707 Domain of unknown function DUF; Region: DUF204; pfam02659 758793011708 Domain of unknown function DUF; Region: DUF204; pfam02659 758793011709 alanine racemase; Reviewed; Region: dadX; PRK03646 758793011710 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 758793011711 active site 758793011712 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758793011713 substrate binding site [chemical binding]; other site 758793011714 catalytic residues [active] 758793011715 dimer interface [polypeptide binding]; other site 758793011716 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 758793011717 dimanganese center [ion binding]; other site 758793011718 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793011719 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793011720 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 758793011721 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 758793011722 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 758793011723 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 758793011724 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758793011725 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 758793011726 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758793011727 PAS domain S-box; Region: sensory_box; TIGR00229 758793011728 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793011729 putative active site [active] 758793011730 heme pocket [chemical binding]; other site 758793011731 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 758793011732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793011733 putative active site [active] 758793011734 heme pocket [chemical binding]; other site 758793011735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793011736 dimer interface [polypeptide binding]; other site 758793011737 phosphorylation site [posttranslational modification] 758793011738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793011739 ATP binding site [chemical binding]; other site 758793011740 Mg2+ binding site [ion binding]; other site 758793011741 G-X-G motif; other site 758793011742 Response regulator receiver domain; Region: Response_reg; pfam00072 758793011743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793011744 active site 758793011745 phosphorylation site [posttranslational modification] 758793011746 intermolecular recognition site; other site 758793011747 dimerization interface [polypeptide binding]; other site 758793011748 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 758793011749 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 758793011750 NADP binding site [chemical binding]; other site 758793011751 active site 758793011752 regulatory binding site [polypeptide binding]; other site 758793011753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793011754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793011756 dimerization interface [polypeptide binding]; other site 758793011757 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793011758 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011759 DNA-binding site [nucleotide binding]; DNA binding site 758793011760 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793011761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793011762 homodimer interface [polypeptide binding]; other site 758793011763 catalytic residue [active] 758793011764 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 758793011765 Putative amidotransferase; Region: DUF4066; pfam13278 758793011766 conserved cys residue [active] 758793011767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011768 DNA-binding site [nucleotide binding]; DNA binding site 758793011769 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758793011770 UTRA domain; Region: UTRA; pfam07702 758793011771 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 758793011772 Phosphotransferase enzyme family; Region: APH; pfam01636 758793011773 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 758793011774 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 758793011775 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 758793011776 intersubunit interface [polypeptide binding]; other site 758793011777 active site 758793011778 Zn2+ binding site [ion binding]; other site 758793011779 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 758793011780 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793011781 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793011782 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793011783 Walker A/P-loop; other site 758793011784 ATP binding site [chemical binding]; other site 758793011785 Q-loop/lid; other site 758793011786 ABC transporter signature motif; other site 758793011787 Walker B; other site 758793011788 D-loop; other site 758793011789 H-loop/switch region; other site 758793011790 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793011791 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793011792 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793011793 TM-ABC transporter signature motif; other site 758793011794 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 758793011795 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 758793011796 DAK2 domain; Region: Dak2; cl03685 758793011797 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 758793011798 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793011799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793011800 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 758793011801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011802 D-galactonate transporter; Region: 2A0114; TIGR00893 758793011803 putative substrate translocation pore; other site 758793011804 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 758793011805 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 758793011806 peptide binding site [polypeptide binding]; other site 758793011807 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793011808 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 758793011809 acyl-activating enzyme (AAE) consensus motif; other site 758793011810 AMP binding site [chemical binding]; other site 758793011811 active site 758793011812 CoA binding site [chemical binding]; other site 758793011813 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758793011814 homotrimer interaction site [polypeptide binding]; other site 758793011815 putative active site [active] 758793011816 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758793011817 active site 758793011818 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793011819 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793011820 active site 758793011821 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 758793011822 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793011823 substrate binding site [chemical binding]; other site 758793011824 oxyanion hole (OAH) forming residues; other site 758793011825 trimer interface [polypeptide binding]; other site 758793011826 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793011827 MarR family; Region: MarR; pfam01047 758793011828 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793011829 classical (c) SDRs; Region: SDR_c; cd05233 758793011830 NAD(P) binding site [chemical binding]; other site 758793011831 active site 758793011832 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 758793011833 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793011834 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 758793011835 active site 758793011836 FMN binding site [chemical binding]; other site 758793011837 substrate binding site [chemical binding]; other site 758793011838 homotetramer interface [polypeptide binding]; other site 758793011839 catalytic residue [active] 758793011840 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 758793011841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793011842 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793011843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793011844 ligand binding site [chemical binding]; other site 758793011845 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 758793011846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793011847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793011848 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 758793011849 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 758793011850 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793011851 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 758793011852 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 758793011853 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793011854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011855 putative substrate translocation pore; other site 758793011856 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 758793011857 short chain dehydrogenase; Provisional; Region: PRK12829 758793011858 classical (c) SDRs; Region: SDR_c; cd05233 758793011859 NAD(P) binding site [chemical binding]; other site 758793011860 active site 758793011861 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793011862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793011863 DNA-binding site [nucleotide binding]; DNA binding site 758793011864 FCD domain; Region: FCD; pfam07729 758793011865 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758793011866 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758793011867 Walker A/P-loop; other site 758793011868 ATP binding site [chemical binding]; other site 758793011869 Q-loop/lid; other site 758793011870 ABC transporter signature motif; other site 758793011871 Walker B; other site 758793011872 D-loop; other site 758793011873 H-loop/switch region; other site 758793011874 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758793011875 FtsX-like permease family; Region: FtsX; pfam02687 758793011876 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758793011877 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758793011878 FtsX-like permease family; Region: FtsX; pfam02687 758793011879 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 758793011880 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793011881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793011882 metal binding site [ion binding]; metal-binding site 758793011883 active site 758793011884 I-site; other site 758793011885 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 758793011886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793011887 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 758793011888 DNA binding residues [nucleotide binding] 758793011889 MbtH-like protein; Region: MbtH; cl01279 758793011890 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 758793011891 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 758793011892 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 758793011893 Walker A/P-loop; other site 758793011894 ATP binding site [chemical binding]; other site 758793011895 Q-loop/lid; other site 758793011896 ABC transporter signature motif; other site 758793011897 Walker B; other site 758793011898 D-loop; other site 758793011899 H-loop/switch region; other site 758793011900 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 758793011901 FecCD transport family; Region: FecCD; pfam01032 758793011902 ABC-ATPase subunit interface; other site 758793011903 dimer interface [polypeptide binding]; other site 758793011904 putative PBP binding regions; other site 758793011905 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 758793011906 ABC-ATPase subunit interface; other site 758793011907 dimer interface [polypeptide binding]; other site 758793011908 putative PBP binding regions; other site 758793011909 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 758793011910 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 758793011911 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 758793011912 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 758793011913 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 758793011914 siderophore binding site; other site 758793011915 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 758793011916 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 758793011917 Walker A/P-loop; other site 758793011918 ATP binding site [chemical binding]; other site 758793011919 Q-loop/lid; other site 758793011920 ABC transporter signature motif; other site 758793011921 Walker B; other site 758793011922 D-loop; other site 758793011923 H-loop/switch region; other site 758793011924 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 758793011925 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 758793011926 acyl-activating enzyme (AAE) consensus motif; other site 758793011927 AMP binding site [chemical binding]; other site 758793011928 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 758793011929 Condensation domain; Region: Condensation; pfam00668 758793011930 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 758793011931 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 758793011932 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 758793011933 acyl-activating enzyme (AAE) consensus motif; other site 758793011934 AMP binding site [chemical binding]; other site 758793011935 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 758793011936 Condensation domain; Region: Condensation; pfam00668 758793011937 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 758793011938 Condensation domain; Region: Condensation; pfam00668 758793011939 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 758793011940 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 758793011941 acyl-activating enzyme (AAE) consensus motif; other site 758793011942 AMP binding site [chemical binding]; other site 758793011943 Condensation domain; Region: Condensation; pfam00668 758793011944 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 758793011945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 758793011946 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 758793011947 acyl-activating enzyme (AAE) consensus motif; other site 758793011948 AMP binding site [chemical binding]; other site 758793011949 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 758793011950 Condensation domain; Region: Condensation; pfam00668 758793011951 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 758793011952 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 758793011953 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 758793011954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793011955 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793011956 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 758793011957 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793011958 N-terminal plug; other site 758793011959 ligand-binding site [chemical binding]; other site 758793011960 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 758793011961 active site 758793011962 cosubstrate binding site; other site 758793011963 substrate binding site [chemical binding]; other site 758793011964 catalytic site [active] 758793011965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 758793011966 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 758793011967 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 758793011968 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 758793011969 putative active site [active] 758793011970 metal binding site [ion binding]; metal-binding site 758793011971 Urea transporter; Region: UT; cl01829 758793011972 aldolase II superfamily protein; Provisional; Region: PRK07044 758793011973 intersubunit interface [polypeptide binding]; other site 758793011974 active site 758793011975 Zn2+ binding site [ion binding]; other site 758793011976 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 758793011977 active site 1 [active] 758793011978 dimer interface [polypeptide binding]; other site 758793011979 hexamer interface [polypeptide binding]; other site 758793011980 active site 2 [active] 758793011981 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 758793011982 active site 758793011983 Uncharacterized conserved protein [Function unknown]; Region: COG2361 758793011984 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793011985 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793011986 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793011987 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 758793011988 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 758793011989 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793011990 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793011991 catalytic loop [active] 758793011992 iron binding site [ion binding]; other site 758793011993 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793011994 citrate-proton symporter; Provisional; Region: PRK15075 758793011995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793011996 putative substrate translocation pore; other site 758793011997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793011998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793011999 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793012000 dimerization interface [polypeptide binding]; other site 758793012001 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 758793012002 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 758793012003 metal binding site [ion binding]; metal-binding site 758793012004 putative dimer interface [polypeptide binding]; other site 758793012005 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 758793012006 putative active site [active] 758793012007 Zn binding site [ion binding]; other site 758793012008 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 758793012009 High potential iron-sulfur protein; Region: HIPIP; pfam01355 758793012010 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 758793012011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012012 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 758793012013 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793012014 NAD(P) binding site [chemical binding]; other site 758793012015 catalytic residues [active] 758793012016 Protein of unknown function (DUF779); Region: DUF779; pfam05610 758793012017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793012018 enoyl-CoA hydratase; Validated; Region: PRK08139 758793012019 substrate binding site [chemical binding]; other site 758793012020 oxyanion hole (OAH) forming residues; other site 758793012021 trimer interface [polypeptide binding]; other site 758793012022 acyl-CoA synthetase; Validated; Region: PRK08162 758793012023 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 758793012024 acyl-activating enzyme (AAE) consensus motif; other site 758793012025 putative active site [active] 758793012026 AMP binding site [chemical binding]; other site 758793012027 putative CoA binding site [chemical binding]; other site 758793012028 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 758793012029 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 758793012030 C-terminal domain interface [polypeptide binding]; other site 758793012031 GSH binding site (G-site) [chemical binding]; other site 758793012032 dimer interface [polypeptide binding]; other site 758793012033 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793012034 N-terminal domain interface [polypeptide binding]; other site 758793012035 dimer interface [polypeptide binding]; other site 758793012036 substrate binding pocket (H-site) [chemical binding]; other site 758793012037 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793012038 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 758793012039 putative C-terminal domain interface [polypeptide binding]; other site 758793012040 putative GSH binding site (G-site) [chemical binding]; other site 758793012041 putative dimer interface [polypeptide binding]; other site 758793012042 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 758793012043 putative N-terminal domain interface [polypeptide binding]; other site 758793012044 putative dimer interface [polypeptide binding]; other site 758793012045 putative substrate binding pocket (H-site) [chemical binding]; other site 758793012046 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 758793012047 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793012048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793012049 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793012050 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 758793012051 putative substrate binding pocket [chemical binding]; other site 758793012052 putative dimerization interface [polypeptide binding]; other site 758793012053 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793012054 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 758793012055 putative ligand binding site [chemical binding]; other site 758793012056 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793012057 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793012058 TM-ABC transporter signature motif; other site 758793012059 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793012060 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793012061 TM-ABC transporter signature motif; other site 758793012062 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793012063 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793012064 Walker A/P-loop; other site 758793012065 ATP binding site [chemical binding]; other site 758793012066 Q-loop/lid; other site 758793012067 ABC transporter signature motif; other site 758793012068 Walker B; other site 758793012069 D-loop; other site 758793012070 H-loop/switch region; other site 758793012071 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793012072 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793012073 Walker A/P-loop; other site 758793012074 ATP binding site [chemical binding]; other site 758793012075 Q-loop/lid; other site 758793012076 ABC transporter signature motif; other site 758793012077 Walker B; other site 758793012078 D-loop; other site 758793012079 H-loop/switch region; other site 758793012080 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 758793012081 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793012082 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793012083 trimer interface [polypeptide binding]; other site 758793012084 eyelet of channel; other site 758793012085 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 758793012086 active site 758793012087 catalytic residues [active] 758793012088 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 758793012089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793012090 motif II; other site 758793012091 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 758793012092 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 758793012093 GAF domain; Region: GAF_2; pfam13185 758793012094 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793012095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793012096 dimer interface [polypeptide binding]; other site 758793012097 phosphorylation site [posttranslational modification] 758793012098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793012099 ATP binding site [chemical binding]; other site 758793012100 Mg2+ binding site [ion binding]; other site 758793012101 G-X-G motif; other site 758793012102 Response regulator receiver domain; Region: Response_reg; pfam00072 758793012103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012104 active site 758793012105 phosphorylation site [posttranslational modification] 758793012106 intermolecular recognition site; other site 758793012107 dimerization interface [polypeptide binding]; other site 758793012108 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793012109 GAF domain; Region: GAF; pfam01590 758793012110 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793012111 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 758793012112 putative active site [active] 758793012113 heme pocket [chemical binding]; other site 758793012114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793012115 dimer interface [polypeptide binding]; other site 758793012116 phosphorylation site [posttranslational modification] 758793012117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793012118 ATP binding site [chemical binding]; other site 758793012119 Mg2+ binding site [ion binding]; other site 758793012120 G-X-G motif; other site 758793012121 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793012122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012123 active site 758793012124 phosphorylation site [posttranslational modification] 758793012125 intermolecular recognition site; other site 758793012126 dimerization interface [polypeptide binding]; other site 758793012127 Response regulator receiver domain; Region: Response_reg; pfam00072 758793012128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012129 active site 758793012130 phosphorylation site [posttranslational modification] 758793012131 intermolecular recognition site; other site 758793012132 dimerization interface [polypeptide binding]; other site 758793012133 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793012134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012135 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793012136 Methyltransferase domain; Region: Methyltransf_11; pfam08241 758793012137 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793012138 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793012139 TM-ABC transporter signature motif; other site 758793012140 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793012141 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793012142 TM-ABC transporter signature motif; other site 758793012143 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793012144 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793012145 Walker A/P-loop; other site 758793012146 ATP binding site [chemical binding]; other site 758793012147 Q-loop/lid; other site 758793012148 ABC transporter signature motif; other site 758793012149 Walker B; other site 758793012150 D-loop; other site 758793012151 H-loop/switch region; other site 758793012152 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793012153 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 758793012154 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 758793012155 putative ligand binding site [chemical binding]; other site 758793012156 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793012157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793012158 DNA binding site [nucleotide binding] 758793012159 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 758793012160 putative dimerization interface [polypeptide binding]; other site 758793012161 putative ligand binding site [chemical binding]; other site 758793012162 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 758793012163 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 758793012164 active site 758793012165 catalytic residues [active] 758793012166 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 758793012167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793012168 FeS/SAM binding site; other site 758793012169 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 758793012170 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 758793012171 Fe-S cluster binding site [ion binding]; other site 758793012172 active site 758793012173 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 758793012174 classical (c) SDRs; Region: SDR_c; cd05233 758793012175 NAD(P) binding site [chemical binding]; other site 758793012176 active site 758793012177 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 758793012178 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 758793012179 PLD-like domain; Region: PLDc_2; pfam13091 758793012180 putative active site [active] 758793012181 catalytic site [active] 758793012182 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 758793012183 PLD-like domain; Region: PLDc_2; pfam13091 758793012184 putative active site [active] 758793012185 catalytic site [active] 758793012186 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 758793012187 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 758793012188 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 758793012189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793012190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793012191 metal binding site [ion binding]; metal-binding site 758793012192 active site 758793012193 I-site; other site 758793012194 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793012195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793012196 binding surface 758793012197 TPR motif; other site 758793012198 Tetratricopeptide repeat; Region: TPR_16; pfam13432 758793012199 TPR repeat; Region: TPR_11; pfam13414 758793012200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793012201 TPR motif; other site 758793012202 binding surface 758793012203 TPR repeat; Region: TPR_11; pfam13414 758793012204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793012205 binding surface 758793012206 TPR motif; other site 758793012207 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793012208 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 758793012209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012210 putative substrate translocation pore; other site 758793012211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012212 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793012213 MarR family; Region: MarR; pfam01047 758793012214 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 758793012215 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 758793012216 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 758793012217 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 758793012218 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 758793012219 TadE-like protein; Region: TadE; pfam07811 758793012220 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 758793012221 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 758793012222 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 758793012223 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 758793012224 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 758793012225 AAA domain; Region: AAA_31; pfam13614 758793012226 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 758793012227 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 758793012228 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 758793012229 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 758793012230 ATP binding site [chemical binding]; other site 758793012231 Walker A motif; other site 758793012232 hexamer interface [polypeptide binding]; other site 758793012233 Walker B motif; other site 758793012234 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 758793012235 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758793012236 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 758793012237 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 758793012238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793012239 TPR motif; other site 758793012240 binding surface 758793012241 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 758793012242 Predicted membrane protein [Function unknown]; Region: COG4655 758793012243 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 758793012244 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 758793012245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793012246 Walker A motif; other site 758793012247 ATP binding site [chemical binding]; other site 758793012248 Walker B motif; other site 758793012249 arginine finger; other site 758793012250 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793012251 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793012252 Spore Coat Protein U domain; Region: SCPU; pfam05229 758793012253 Uncharacterized secreted protein [Function unknown]; Region: COG5430 758793012254 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 758793012255 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 758793012256 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 758793012257 PapC C-terminal domain; Region: PapC_C; pfam13953 758793012258 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 758793012259 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 758793012260 Uncharacterized secreted protein [Function unknown]; Region: COG5430 758793012261 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 758793012262 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 758793012263 Walker A/P-loop; other site 758793012264 ATP binding site [chemical binding]; other site 758793012265 Q-loop/lid; other site 758793012266 ABC transporter signature motif; other site 758793012267 Walker B; other site 758793012268 D-loop; other site 758793012269 H-loop/switch region; other site 758793012270 TOBE domain; Region: TOBE_2; pfam08402 758793012271 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 758793012272 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758793012273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793012274 dimer interface [polypeptide binding]; other site 758793012275 conserved gate region; other site 758793012276 putative PBP binding loops; other site 758793012277 ABC-ATPase subunit interface; other site 758793012278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758793012279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793012280 dimer interface [polypeptide binding]; other site 758793012281 conserved gate region; other site 758793012282 putative PBP binding loops; other site 758793012283 ABC-ATPase subunit interface; other site 758793012284 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 758793012285 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 758793012286 non-specific DNA interactions [nucleotide binding]; other site 758793012287 DNA binding site [nucleotide binding] 758793012288 sequence specific DNA binding site [nucleotide binding]; other site 758793012289 putative cAMP binding site [chemical binding]; other site 758793012290 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 758793012291 short chain dehydrogenase; Provisional; Region: PRK07060 758793012292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793012293 NAD(P) binding site [chemical binding]; other site 758793012294 active site 758793012295 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 758793012296 L-idonate 5-dehydrogenase; Region: PLN02702 758793012297 inhibitor binding site; inhibition site 758793012298 catalytic Zn binding site [ion binding]; other site 758793012299 structural Zn binding site [ion binding]; other site 758793012300 NADP binding site [chemical binding]; other site 758793012301 tetramer interface [polypeptide binding]; other site 758793012302 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 758793012303 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758793012304 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793012305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793012306 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 758793012307 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 758793012308 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793012309 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793012310 active site 758793012311 catalytic tetrad [active] 758793012312 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 758793012313 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793012314 iron-sulfur cluster [ion binding]; other site 758793012315 [2Fe-2S] cluster binding site [ion binding]; other site 758793012316 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 758793012317 hydrophobic ligand binding site; other site 758793012318 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793012319 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793012320 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793012321 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793012322 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 758793012323 FMN-binding pocket [chemical binding]; other site 758793012324 flavin binding motif; other site 758793012325 phosphate binding motif [ion binding]; other site 758793012326 beta-alpha-beta structure motif; other site 758793012327 NAD binding pocket [chemical binding]; other site 758793012328 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793012329 catalytic loop [active] 758793012330 iron binding site [ion binding]; other site 758793012331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012332 putative substrate translocation pore; other site 758793012333 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 758793012334 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 758793012335 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 758793012336 NAD(P) binding site [chemical binding]; other site 758793012337 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 758793012338 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793012339 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 758793012340 alpha subunit interface [polypeptide binding]; other site 758793012341 active site 758793012342 substrate binding site [chemical binding]; other site 758793012343 Fe binding site [ion binding]; other site 758793012344 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 758793012345 [2Fe-2S] cluster binding site [ion binding]; other site 758793012346 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 758793012347 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793012348 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 758793012349 intersubunit interface [polypeptide binding]; other site 758793012350 active site 758793012351 Zn2+ binding site [ion binding]; other site 758793012352 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793012353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793012354 dimer interface [polypeptide binding]; other site 758793012355 conserved gate region; other site 758793012356 putative PBP binding loops; other site 758793012357 ABC-ATPase subunit interface; other site 758793012358 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793012359 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793012360 Walker A/P-loop; other site 758793012361 ATP binding site [chemical binding]; other site 758793012362 Q-loop/lid; other site 758793012363 ABC transporter signature motif; other site 758793012364 Walker B; other site 758793012365 D-loop; other site 758793012366 H-loop/switch region; other site 758793012367 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793012368 NMT1-like family; Region: NMT1_2; pfam13379 758793012369 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793012370 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793012371 trimer interface [polypeptide binding]; other site 758793012372 eyelet of channel; other site 758793012373 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793012374 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793012375 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793012376 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 758793012377 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793012378 catalytic loop [active] 758793012379 iron binding site [ion binding]; other site 758793012380 Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190 758793012381 FAD binding pocket [chemical binding]; other site 758793012382 FAD binding motif [chemical binding]; other site 758793012383 phosphate binding motif [ion binding]; other site 758793012384 beta-alpha-beta structure motif; other site 758793012385 NAD binding pocket [chemical binding]; other site 758793012386 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793012387 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 758793012388 diiron binding motif [ion binding]; other site 758793012389 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 758793012390 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793012391 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 758793012392 FMN-binding pocket [chemical binding]; other site 758793012393 flavin binding motif; other site 758793012394 phosphate binding motif [ion binding]; other site 758793012395 beta-alpha-beta structure motif; other site 758793012396 NAD binding pocket [chemical binding]; other site 758793012397 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793012398 catalytic loop [active] 758793012399 iron binding site [ion binding]; other site 758793012400 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793012401 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793012402 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793012403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793012404 MarR family; Region: MarR; pfam01047 758793012405 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 758793012406 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793012407 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 758793012408 alpha subunit interface [polypeptide binding]; other site 758793012409 active site 758793012410 substrate binding site [chemical binding]; other site 758793012411 Fe binding site [ion binding]; other site 758793012412 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 758793012413 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 758793012414 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 758793012415 intersubunit interface [polypeptide binding]; other site 758793012416 active site 758793012417 Zn2+ binding site [ion binding]; other site 758793012418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 758793012419 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793012420 Chromate transporter; Region: Chromate_transp; pfam02417 758793012421 Chromate transporter; Region: Chromate_transp; pfam02417 758793012422 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 758793012423 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 758793012424 putative NAD(P) binding site [chemical binding]; other site 758793012425 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793012426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793012427 LysR substrate binding domain; Region: LysR_substrate; pfam03466 758793012428 dimerization interface [polypeptide binding]; other site 758793012429 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793012430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793012431 catalytic loop [active] 758793012432 iron binding site [ion binding]; other site 758793012433 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793012434 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793012435 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793012436 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793012437 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793012438 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793012439 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793012440 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793012441 Cytochrome c; Region: Cytochrom_C; pfam00034 758793012442 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 758793012443 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 758793012444 H-NS histone family; Region: Histone_HNS; pfam00816 758793012445 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 758793012446 amidase; Provisional; Region: PRK07486 758793012447 Amidase; Region: Amidase; cl11426 758793012448 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 758793012449 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 758793012450 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 758793012451 Na binding site [ion binding]; other site 758793012452 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 758793012453 Uncharacterized conserved protein [Function unknown]; Region: COG4121 758793012454 hypothetical protein; Provisional; Region: PRK11239 758793012455 Protein of unknown function, DUF480; Region: DUF480; pfam04337 758793012456 Uncharacterized conserved protein [Function unknown]; Region: COG2308 758793012457 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 758793012458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 758793012459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 758793012460 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 758793012461 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 758793012462 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 758793012463 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758793012464 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 758793012465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 758793012466 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 758793012467 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 758793012468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 758793012469 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 758793012470 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 758793012471 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758793012472 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793012473 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793012474 active site 758793012475 catalytic tetrad [active] 758793012476 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 758793012477 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 758793012478 putative active site [active] 758793012479 catalytic site [active] 758793012480 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 758793012481 putative active site [active] 758793012482 catalytic site [active] 758793012483 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 758793012484 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 758793012485 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 758793012486 dimerization interface [polypeptide binding]; other site 758793012487 NAD binding site [chemical binding]; other site 758793012488 ligand binding site [chemical binding]; other site 758793012489 catalytic site [active] 758793012490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793012491 Uncharacterized conserved protein [Function unknown]; Region: COG3391 758793012492 NHL repeat; Region: NHL; pfam01436 758793012493 AlkA N-terminal domain; Region: AlkA_N; pfam06029 758793012494 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 758793012495 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 758793012496 minor groove reading motif; other site 758793012497 helix-hairpin-helix signature motif; other site 758793012498 substrate binding pocket [chemical binding]; other site 758793012499 active site 758793012500 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793012501 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793012502 DNA-binding site [nucleotide binding]; DNA binding site 758793012503 FCD domain; Region: FCD; pfam07729 758793012504 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 758793012505 homodimer interface [polypeptide binding]; other site 758793012506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793012507 catalytic residue [active] 758793012508 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 758793012509 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793012510 FAD binding domain; Region: FAD_binding_4; pfam01565 758793012511 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 758793012512 Cysteine-rich domain; Region: CCG; pfam02754 758793012513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012514 D-galactonate transporter; Region: 2A0114; TIGR00893 758793012515 putative substrate translocation pore; other site 758793012516 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793012517 trimer interface [polypeptide binding]; other site 758793012518 oxyanion hole (OAH) forming residues; other site 758793012519 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793012520 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793012521 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 758793012522 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 758793012523 dimer interface [polypeptide binding]; other site 758793012524 active site 758793012525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758793012526 substrate binding site [chemical binding]; other site 758793012527 catalytic residue [active] 758793012528 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793012529 Pulmonary surfactant proteins; Region: SF_P; smart00019 758793012530 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 758793012531 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793012532 membrane-bound complex binding site; other site 758793012533 hinge residues; other site 758793012534 Cytochrome c; Region: Cytochrom_C; pfam00034 758793012535 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 758793012536 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 758793012537 dimer interface [polypeptide binding]; other site 758793012538 Trp docking motif [polypeptide binding]; other site 758793012539 active site 758793012540 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 758793012541 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 758793012542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793012543 Walker A motif; other site 758793012544 ATP binding site [chemical binding]; other site 758793012545 Walker B motif; other site 758793012546 arginine finger; other site 758793012547 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793012548 LysE type translocator; Region: LysE; cl00565 758793012549 Cache domain; Region: Cache_1; pfam02743 758793012550 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793012551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793012552 metal binding site [ion binding]; metal-binding site 758793012553 active site 758793012554 I-site; other site 758793012555 Uncharacterized conserved protein [Function unknown]; Region: COG5476 758793012556 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 758793012557 MlrC C-terminus; Region: MlrC_C; pfam07171 758793012558 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 758793012559 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 758793012560 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 758793012561 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 758793012562 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 758793012563 putative active site pocket [active] 758793012564 putative metal binding site [ion binding]; other site 758793012565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012566 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793012567 putative substrate translocation pore; other site 758793012568 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 758793012569 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 758793012570 putative NAD(P) binding site [chemical binding]; other site 758793012571 catalytic Zn binding site [ion binding]; other site 758793012572 D-galactonate transporter; Region: 2A0114; TIGR00893 758793012573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012574 putative substrate translocation pore; other site 758793012575 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793012576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793012577 DNA-binding site [nucleotide binding]; DNA binding site 758793012578 FCD domain; Region: FCD; pfam07729 758793012579 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 758793012580 tartrate dehydrogenase; Region: TTC; TIGR02089 758793012581 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793012582 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793012583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 758793012584 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 758793012585 Walker A/P-loop; other site 758793012586 ATP binding site [chemical binding]; other site 758793012587 Q-loop/lid; other site 758793012588 ABC transporter signature motif; other site 758793012589 Walker B; other site 758793012590 D-loop; other site 758793012591 H-loop/switch region; other site 758793012592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758793012593 FtsX-like permease family; Region: FtsX; pfam02687 758793012594 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 758793012595 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 758793012596 FtsX-like permease family; Region: FtsX; pfam02687 758793012597 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 758793012598 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 758793012599 Phosphoesterase family; Region: Phosphoesterase; pfam04185 758793012600 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 758793012601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793012602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 758793012603 Coenzyme A binding pocket [chemical binding]; other site 758793012604 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 758793012605 spermidine synthase; Provisional; Region: PRK03612 758793012606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 758793012607 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 758793012608 Sulfatase; Region: Sulfatase; pfam00884 758793012609 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 758793012610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793012611 motif II; other site 758793012612 Uncharacterized conserved protein [Function unknown]; Region: COG1262 758793012613 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 758793012614 MoxR-like ATPases [General function prediction only]; Region: COG0714 758793012615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793012616 Walker A motif; other site 758793012617 ATP binding site [chemical binding]; other site 758793012618 Walker B motif; other site 758793012619 arginine finger; other site 758793012620 Protein of unknown function DUF58; Region: DUF58; pfam01882 758793012621 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 758793012622 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 758793012623 metal ion-dependent adhesion site (MIDAS); other site 758793012624 von Willebrand factor type A domain; Region: VWA_2; pfam13519 758793012625 metal ion-dependent adhesion site (MIDAS); other site 758793012626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793012627 Tetratricopeptide repeat; Region: TPR_16; pfam13432 758793012628 TPR motif; other site 758793012629 binding surface 758793012630 Oxygen tolerance; Region: BatD; pfam13584 758793012631 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 758793012632 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 758793012633 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 758793012634 Domain of unknown function (DUF802); Region: DUF802; pfam05650 758793012635 Domain of unknown function (DUF802); Region: DUF802; pfam05650 758793012636 hypothetical protein; Provisional; Region: PRK09040 758793012637 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793012638 ligand binding site [chemical binding]; other site 758793012639 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 758793012640 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 758793012641 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758793012642 PYR/PP interface [polypeptide binding]; other site 758793012643 dimer interface [polypeptide binding]; other site 758793012644 TPP binding site [chemical binding]; other site 758793012645 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793012646 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 758793012647 TPP-binding site [chemical binding]; other site 758793012648 dimer interface [polypeptide binding]; other site 758793012649 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793012650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012651 putative substrate translocation pore; other site 758793012652 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793012653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793012654 NAD(P) binding site [chemical binding]; other site 758793012655 active site 758793012656 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793012657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793012658 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793012659 dimerization interface [polypeptide binding]; other site 758793012660 substrate binding pocket [chemical binding]; other site 758793012661 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 758793012662 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 758793012663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793012664 PAS domain; Region: PAS_9; pfam13426 758793012665 putative active site [active] 758793012666 heme pocket [chemical binding]; other site 758793012667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793012668 PAS domain; Region: PAS_9; pfam13426 758793012669 putative active site [active] 758793012670 heme pocket [chemical binding]; other site 758793012671 PAS domain S-box; Region: sensory_box; TIGR00229 758793012672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793012673 putative active site [active] 758793012674 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 758793012675 heme pocket [chemical binding]; other site 758793012676 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 758793012677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793012678 dimer interface [polypeptide binding]; other site 758793012679 phosphorylation site [posttranslational modification] 758793012680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793012681 ATP binding site [chemical binding]; other site 758793012682 Mg2+ binding site [ion binding]; other site 758793012683 G-X-G motif; other site 758793012684 Response regulator receiver domain; Region: Response_reg; pfam00072 758793012685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012686 active site 758793012687 phosphorylation site [posttranslational modification] 758793012688 intermolecular recognition site; other site 758793012689 dimerization interface [polypeptide binding]; other site 758793012690 GntP family permease; Region: GntP_permease; pfam02447 758793012691 fructuronate transporter; Provisional; Region: PRK10034; cl15264 758793012692 citrate-proton symporter; Provisional; Region: PRK15075 758793012693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012694 putative substrate translocation pore; other site 758793012695 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 758793012696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793012697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793012698 DNA binding residues [nucleotide binding] 758793012699 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 758793012700 Uncharacterized conserved protein [Function unknown]; Region: COG2128 758793012701 Cupin domain; Region: Cupin_2; pfam07883 758793012702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793012703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793012704 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793012705 putative effector binding pocket; other site 758793012706 dimerization interface [polypeptide binding]; other site 758793012707 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 758793012708 benzoate transport; Region: 2A0115; TIGR00895 758793012709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012710 putative substrate translocation pore; other site 758793012711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012712 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793012713 classical (c) SDRs; Region: SDR_c; cd05233 758793012714 NAD(P) binding site [chemical binding]; other site 758793012715 active site 758793012716 NIPSNAP; Region: NIPSNAP; pfam07978 758793012717 putative succinate dehydrogenase; Reviewed; Region: PRK12842 758793012718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793012719 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 758793012720 classical (c) SDRs; Region: SDR_c; cd05233 758793012721 NAD(P) binding site [chemical binding]; other site 758793012722 active site 758793012723 Cupin domain; Region: Cupin_2; cl17218 758793012724 Helix-turn-helix domain; Region: HTH_18; pfam12833 758793012725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793012726 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 758793012727 Trehalase; Region: Trehalase; cl17346 758793012728 Cytochrome c; Region: Cytochrom_C; pfam00034 758793012729 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 758793012730 sulfite oxidase; Provisional; Region: PLN00177 758793012731 Moco binding site; other site 758793012732 metal coordination site [ion binding]; other site 758793012733 dimerization interface [polypeptide binding]; other site 758793012734 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 758793012735 active site 1 [active] 758793012736 dimer interface [polypeptide binding]; other site 758793012737 hexamer interface [polypeptide binding]; other site 758793012738 active site 2 [active] 758793012739 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793012740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793012741 NAD(P) binding site [chemical binding]; other site 758793012742 active site 758793012743 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 758793012744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793012745 motif II; other site 758793012746 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 758793012747 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793012748 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793012749 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 758793012750 tetramer interface [polypeptide binding]; other site 758793012751 active site 758793012752 Mg2+/Mn2+ binding site [ion binding]; other site 758793012753 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793012754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758793012755 active site 758793012756 benzoate transport; Region: 2A0115; TIGR00895 758793012757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012758 putative substrate translocation pore; other site 758793012759 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 758793012760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793012761 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 758793012762 dimerization interface [polypeptide binding]; other site 758793012763 substrate binding pocket [chemical binding]; other site 758793012764 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793012765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793012766 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 758793012767 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793012768 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 758793012769 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 758793012770 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 758793012771 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 758793012772 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 758793012773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793012774 Walker A motif; other site 758793012775 ATP binding site [chemical binding]; other site 758793012776 Walker B motif; other site 758793012777 arginine finger; other site 758793012778 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793012779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793012780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012781 active site 758793012782 phosphorylation site [posttranslational modification] 758793012783 intermolecular recognition site; other site 758793012784 dimerization interface [polypeptide binding]; other site 758793012785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012786 active site 758793012787 dimerization interface [polypeptide binding]; other site 758793012788 Response regulator receiver domain; Region: Response_reg; pfam00072 758793012789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012790 active site 758793012791 phosphorylation site [posttranslational modification] 758793012792 intermolecular recognition site; other site 758793012793 dimerization interface [polypeptide binding]; other site 758793012794 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793012795 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793012796 metal binding site [ion binding]; metal-binding site 758793012797 active site 758793012798 I-site; other site 758793012799 Cache domain; Region: Cache_1; pfam02743 758793012800 PAS domain S-box; Region: sensory_box; TIGR00229 758793012801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793012802 putative active site [active] 758793012803 heme pocket [chemical binding]; other site 758793012804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793012805 PAS fold; Region: PAS_3; pfam08447 758793012806 putative active site [active] 758793012807 heme pocket [chemical binding]; other site 758793012808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793012809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793012810 dimer interface [polypeptide binding]; other site 758793012811 phosphorylation site [posttranslational modification] 758793012812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793012813 ATP binding site [chemical binding]; other site 758793012814 Mg2+ binding site [ion binding]; other site 758793012815 G-X-G motif; other site 758793012816 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793012817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012818 active site 758793012819 phosphorylation site [posttranslational modification] 758793012820 intermolecular recognition site; other site 758793012821 dimerization interface [polypeptide binding]; other site 758793012822 Response regulator receiver domain; Region: Response_reg; pfam00072 758793012823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793012824 active site 758793012825 phosphorylation site [posttranslational modification] 758793012826 intermolecular recognition site; other site 758793012827 dimerization interface [polypeptide binding]; other site 758793012828 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 758793012829 putative binding surface; other site 758793012830 active site 758793012831 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 758793012832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793012833 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 758793012834 catalytic site [active] 758793012835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793012836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793012837 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 758793012838 putative dimerization interface [polypeptide binding]; other site 758793012839 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758793012840 hypothetical protein; Provisional; Region: PRK10621 758793012841 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 758793012842 DNA-binding site [nucleotide binding]; DNA binding site 758793012843 RNA-binding motif; other site 758793012844 hypothetical protein; Provisional; Region: PRK06486 758793012845 intersubunit interface [polypeptide binding]; other site 758793012846 active site 758793012847 Zn2+ binding site [ion binding]; other site 758793012848 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 758793012849 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793012850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793012851 TM-ABC transporter signature motif; other site 758793012852 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793012853 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793012854 Walker A/P-loop; other site 758793012855 ATP binding site [chemical binding]; other site 758793012856 Q-loop/lid; other site 758793012857 ABC transporter signature motif; other site 758793012858 Walker B; other site 758793012859 D-loop; other site 758793012860 H-loop/switch region; other site 758793012861 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793012862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 758793012863 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 758793012864 putative ligand binding site [chemical binding]; other site 758793012865 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793012866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793012867 DNA binding site [nucleotide binding] 758793012868 domain linker motif; other site 758793012869 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 758793012870 ligand binding site [chemical binding]; other site 758793012871 dimerization interface [polypeptide binding]; other site 758793012872 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 758793012873 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 758793012874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793012875 NADH(P)-binding; Region: NAD_binding_10; pfam13460 758793012876 NAD(P) binding site [chemical binding]; other site 758793012877 active site 758793012878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793012879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793012880 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793012881 active site 758793012882 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 758793012883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793012884 DNA binding site [nucleotide binding] 758793012885 domain linker motif; other site 758793012886 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 758793012887 putative ligand binding site [chemical binding]; other site 758793012888 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 758793012889 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 758793012890 putative di-iron ligands [ion binding]; other site 758793012891 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 758793012892 [2Fe-2S] cluster binding site [ion binding]; other site 758793012893 Cache domain; Region: Cache_1; pfam02743 758793012894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793012895 dimerization interface [polypeptide binding]; other site 758793012896 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758793012897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793012898 dimer interface [polypeptide binding]; other site 758793012899 putative CheW interface [polypeptide binding]; other site 758793012900 EamA-like transporter family; Region: EamA; pfam00892 758793012901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012902 D-galactonate transporter; Region: 2A0114; TIGR00893 758793012903 putative substrate translocation pore; other site 758793012904 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793012905 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 758793012906 DNA binding site [nucleotide binding] 758793012907 domain linker motif; other site 758793012908 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 758793012909 dimerization interface [polypeptide binding]; other site 758793012910 ligand binding site [chemical binding]; other site 758793012911 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793012912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793012913 NAD(P) binding site [chemical binding]; other site 758793012914 active site 758793012915 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 758793012916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012917 D-galactonate transporter; Region: 2A0114; TIGR00893 758793012918 putative substrate translocation pore; other site 758793012919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012920 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793012921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793012922 DNA-binding site [nucleotide binding]; DNA binding site 758793012923 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758793012924 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793012925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793012926 NAD(P) binding site [chemical binding]; other site 758793012927 active site 758793012928 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793012929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793012930 dimer interface [polypeptide binding]; other site 758793012931 conserved gate region; other site 758793012932 putative PBP binding loops; other site 758793012933 ABC-ATPase subunit interface; other site 758793012934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793012935 dimer interface [polypeptide binding]; other site 758793012936 conserved gate region; other site 758793012937 putative PBP binding loops; other site 758793012938 ABC-ATPase subunit interface; other site 758793012939 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758793012940 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793012941 Walker A/P-loop; other site 758793012942 ATP binding site [chemical binding]; other site 758793012943 Q-loop/lid; other site 758793012944 ABC transporter signature motif; other site 758793012945 Walker B; other site 758793012946 D-loop; other site 758793012947 H-loop/switch region; other site 758793012948 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793012949 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793012950 substrate binding pocket [chemical binding]; other site 758793012951 membrane-bound complex binding site; other site 758793012952 hinge residues; other site 758793012953 pyruvate dehydrogenase; Provisional; Region: PRK09124 758793012954 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 758793012955 PYR/PP interface [polypeptide binding]; other site 758793012956 dimer interface [polypeptide binding]; other site 758793012957 tetramer interface [polypeptide binding]; other site 758793012958 TPP binding site [chemical binding]; other site 758793012959 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793012960 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 758793012961 TPP-binding site [chemical binding]; other site 758793012962 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 758793012963 putative hydrophobic ligand binding site [chemical binding]; other site 758793012964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793012965 dimerization interface [polypeptide binding]; other site 758793012966 putative DNA binding site [nucleotide binding]; other site 758793012967 putative Zn2+ binding site [ion binding]; other site 758793012968 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793012969 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 758793012970 Cupin domain; Region: Cupin_2; pfam07883 758793012971 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 758793012972 Sodium Bile acid symporter family; Region: SBF; pfam01758 758793012973 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 758793012974 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793012975 catalytic residues [active] 758793012976 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 758793012977 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 758793012978 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 758793012979 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793012980 catalytic residues [active] 758793012981 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 758793012982 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793012983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793012984 DNA-binding site [nucleotide binding]; DNA binding site 758793012985 FCD domain; Region: FCD; pfam07729 758793012986 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 758793012987 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 758793012988 active site 758793012989 tetramer interface [polypeptide binding]; other site 758793012990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793012991 D-galactonate transporter; Region: 2A0114; TIGR00893 758793012992 putative substrate translocation pore; other site 758793012993 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 758793012994 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 758793012995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793012996 substrate binding pocket [chemical binding]; other site 758793012997 membrane-bound complex binding site; other site 758793012998 hinge residues; other site 758793012999 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 758793013000 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 758793013001 active site 758793013002 dimer interface [polypeptide binding]; other site 758793013003 non-prolyl cis peptide bond; other site 758793013004 insertion regions; other site 758793013005 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793013006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793013007 putative PBP binding loops; other site 758793013008 dimer interface [polypeptide binding]; other site 758793013009 ABC-ATPase subunit interface; other site 758793013010 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 758793013011 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793013012 Walker A/P-loop; other site 758793013013 ATP binding site [chemical binding]; other site 758793013014 Q-loop/lid; other site 758793013015 ABC transporter signature motif; other site 758793013016 Walker B; other site 758793013017 D-loop; other site 758793013018 H-loop/switch region; other site 758793013019 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 758793013020 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793013021 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 758793013022 putative FMN binding site [chemical binding]; other site 758793013023 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 758793013024 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 758793013025 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 758793013026 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 758793013027 intersubunit interface [polypeptide binding]; other site 758793013028 active site 758793013029 catalytic residue [active] 758793013030 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 758793013031 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793013032 NAD(P) binding site [chemical binding]; other site 758793013033 catalytic residues [active] 758793013034 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793013035 NAD(P) binding site [chemical binding]; other site 758793013036 catalytic residues [active] 758793013037 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 758793013038 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 758793013039 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 758793013040 substrate binding site [chemical binding]; other site 758793013041 dimer interface [polypeptide binding]; other site 758793013042 ATP binding site [chemical binding]; other site 758793013043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793013044 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793013045 TM-ABC transporter signature motif; other site 758793013046 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 758793013047 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793013048 ligand binding site [chemical binding]; other site 758793013049 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793013050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793013051 Walker A/P-loop; other site 758793013052 ATP binding site [chemical binding]; other site 758793013053 Q-loop/lid; other site 758793013054 ABC transporter signature motif; other site 758793013055 Walker B; other site 758793013056 D-loop; other site 758793013057 H-loop/switch region; other site 758793013058 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793013059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793013060 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793013061 TM-ABC transporter signature motif; other site 758793013062 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758793013063 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 758793013064 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758793013065 RibD C-terminal domain; Region: RibD_C; cl17279 758793013066 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 758793013067 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758793013068 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 758793013069 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 758793013070 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 758793013071 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 758793013072 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 758793013073 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 758793013074 dimer interface [polypeptide binding]; other site 758793013075 active site 758793013076 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 758793013077 substrate binding site [chemical binding]; other site 758793013078 catalytic residue [active] 758793013079 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 758793013080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793013081 motif II; other site 758793013082 transcriptional activator TtdR; Provisional; Region: PRK09801 758793013083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793013085 dimerization interface [polypeptide binding]; other site 758793013086 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 758793013087 EamA-like transporter family; Region: EamA; pfam00892 758793013088 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 758793013089 [2Fe-2S] cluster binding site [ion binding]; other site 758793013090 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 758793013091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793013092 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793013093 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 758793013094 iron-sulfur cluster [ion binding]; other site 758793013095 [2Fe-2S] cluster binding site [ion binding]; other site 758793013096 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 758793013097 putative alpha subunit interface [polypeptide binding]; other site 758793013098 putative active site [active] 758793013099 putative substrate binding site [chemical binding]; other site 758793013100 Fe binding site [ion binding]; other site 758793013101 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 758793013102 inter-subunit interface; other site 758793013103 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793013104 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793013105 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793013106 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 758793013107 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793013108 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793013109 catalytic loop [active] 758793013110 iron binding site [ion binding]; other site 758793013111 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793013112 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 758793013113 putative hydrophobic ligand binding site [chemical binding]; other site 758793013114 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 758793013115 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 758793013116 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793013117 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793013118 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 758793013119 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 758793013120 Isochorismatase family; Region: Isochorismatase; pfam00857 758793013121 catalytic triad [active] 758793013122 substrate binding site [chemical binding]; other site 758793013123 domain interfaces; other site 758793013124 conserved cis-peptide bond; other site 758793013125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013126 putative substrate translocation pore; other site 758793013127 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793013128 MarR family; Region: MarR; pfam01047 758793013129 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793013130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013131 putative substrate translocation pore; other site 758793013132 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 758793013133 benzoate transporter; Region: benE; TIGR00843 758793013134 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 758793013135 active site 758793013136 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_3; cd06228 758793013137 putative active site [active] 758793013138 Zn binding site [ion binding]; other site 758793013139 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 758793013140 metal ion-dependent adhesion site (MIDAS); other site 758793013141 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013142 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013143 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793013144 dimerization interface [polypeptide binding]; other site 758793013145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013146 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793013147 putative substrate translocation pore; other site 758793013148 allantoate amidohydrolase; Reviewed; Region: PRK12893 758793013149 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 758793013150 active site 758793013151 metal binding site [ion binding]; metal-binding site 758793013152 dimer interface [polypeptide binding]; other site 758793013153 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 758793013154 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 758793013155 active site 758793013156 Zn binding site [ion binding]; other site 758793013157 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 758793013158 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 758793013159 putative acyl-acceptor binding pocket; other site 758793013160 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 758793013161 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 758793013162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793013163 putative active site [active] 758793013164 heme pocket [chemical binding]; other site 758793013165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793013166 dimer interface [polypeptide binding]; other site 758793013167 phosphorylation site [posttranslational modification] 758793013168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793013169 ATP binding site [chemical binding]; other site 758793013170 Mg2+ binding site [ion binding]; other site 758793013171 G-X-G motif; other site 758793013172 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 758793013173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793013174 active site 758793013175 phosphorylation site [posttranslational modification] 758793013176 intermolecular recognition site; other site 758793013177 dimerization interface [polypeptide binding]; other site 758793013178 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793013179 DNA binding residues [nucleotide binding] 758793013180 dimerization interface [polypeptide binding]; other site 758793013181 Response regulator receiver domain; Region: Response_reg; pfam00072 758793013182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793013183 active site 758793013184 phosphorylation site [posttranslational modification] 758793013185 intermolecular recognition site; other site 758793013186 dimerization interface [polypeptide binding]; other site 758793013187 Helix-turn-helix domain; Region: HTH_28; pfam13518 758793013188 Winged helix-turn helix; Region: HTH_29; pfam13551 758793013189 Homeodomain-like domain; Region: HTH_32; pfam13565 758793013190 Integrase core domain; Region: rve; pfam00665 758793013191 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 758793013192 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 758793013193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793013194 Methyltransferase domain; Region: Methyltransf_23; pfam13489 758793013195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793013196 S-adenosylmethionine binding site [chemical binding]; other site 758793013197 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 758793013198 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 758793013199 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 758793013200 dimer interface [polypeptide binding]; other site 758793013201 active site 758793013202 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 758793013203 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 758793013204 dimer interface [polypeptide binding]; other site 758793013205 active site 758793013206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793013207 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 758793013208 NAD(P) binding site [chemical binding]; other site 758793013209 active site 758793013210 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 758793013211 putative active site 1 [active] 758793013212 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 758793013213 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 758793013214 dimer interface [polypeptide binding]; other site 758793013215 active site 758793013216 Predicted exporter [General function prediction only]; Region: COG4258 758793013217 Protein export membrane protein; Region: SecD_SecF; cl14618 758793013218 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 758793013219 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 758793013220 active site 758793013221 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 758793013222 active sites [active] 758793013223 tetramer interface [polypeptide binding]; other site 758793013224 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793013225 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 758793013226 Ligand binding site; other site 758793013227 Putative Catalytic site; other site 758793013228 DXD motif; other site 758793013229 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 758793013230 putative acyl-acceptor binding pocket; other site 758793013231 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 758793013232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793013233 AMP binding site [chemical binding]; other site 758793013234 active site 758793013235 acyl-activating enzyme (AAE) consensus motif; other site 758793013236 CoA binding site [chemical binding]; other site 758793013237 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 758793013238 active site 2 [active] 758793013239 dimer interface [polypeptide binding]; other site 758793013240 active site 1 [active] 758793013241 Predicted membrane protein [Function unknown]; Region: COG4648 758793013242 acyl carrier protein; Provisional; Region: PRK05350 758793013243 Phosphopantetheine attachment site; Region: PP-binding; cl09936 758793013244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758793013245 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758793013246 putative acyl-acceptor binding pocket; other site 758793013247 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 758793013248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793013249 TPR motif; other site 758793013250 binding surface 758793013251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793013252 TPR motif; other site 758793013253 binding surface 758793013254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793013255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793013256 dimerization interface [polypeptide binding]; other site 758793013257 putative DNA binding site [nucleotide binding]; other site 758793013258 putative Zn2+ binding site [ion binding]; other site 758793013259 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 758793013260 hydrophobic ligand binding site; other site 758793013261 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 758793013262 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793013263 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793013264 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 758793013265 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793013266 CHASE3 domain; Region: CHASE3; pfam05227 758793013267 Protein of unknown function, DUF606; Region: DUF606; pfam04657 758793013268 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 758793013269 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 758793013270 transmembrane helices; other site 758793013271 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793013272 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 758793013273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793013274 active site 758793013275 phosphorylation site [posttranslational modification] 758793013276 intermolecular recognition site; other site 758793013277 dimerization interface [polypeptide binding]; other site 758793013278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793013279 Walker A motif; other site 758793013280 ATP binding site [chemical binding]; other site 758793013281 Walker B motif; other site 758793013282 arginine finger; other site 758793013283 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 758793013284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793013285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793013286 dimer interface [polypeptide binding]; other site 758793013287 phosphorylation site [posttranslational modification] 758793013288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793013289 ATP binding site [chemical binding]; other site 758793013290 Mg2+ binding site [ion binding]; other site 758793013291 G-X-G motif; other site 758793013292 HD domain; Region: HD_3; pfam13023 758793013293 Sterile alpha motif; Region: SAM; smart00454 758793013294 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 758793013295 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 758793013296 cyclase homology domain; Region: CHD; cd07302 758793013297 nucleotidyl binding site; other site 758793013298 metal binding site [ion binding]; metal-binding site 758793013299 dimer interface [polypeptide binding]; other site 758793013300 AAA ATPase domain; Region: AAA_16; pfam13191 758793013301 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 758793013302 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793013303 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 758793013304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013305 D-galactonate transporter; Region: 2A0114; TIGR00893 758793013306 putative substrate translocation pore; other site 758793013307 choline dehydrogenase; Validated; Region: PRK02106 758793013308 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793013309 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 758793013310 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 758793013311 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 758793013312 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793013313 NAD binding site [chemical binding]; other site 758793013314 catalytic residues [active] 758793013315 BON domain; Region: BON; pfam04972 758793013316 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793013317 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793013318 eyelet of channel; other site 758793013319 trimer interface [polypeptide binding]; other site 758793013320 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 758793013321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758793013322 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 758793013323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793013324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793013325 DNA binding residues [nucleotide binding] 758793013326 dimerization interface [polypeptide binding]; other site 758793013327 feruloyl-CoA synthase; Reviewed; Region: PRK08180 758793013328 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 758793013329 acyl-activating enzyme (AAE) consensus motif; other site 758793013330 putative AMP binding site [chemical binding]; other site 758793013331 putative active site [active] 758793013332 putative CoA binding site [chemical binding]; other site 758793013333 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793013334 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793013335 active site 758793013336 lipid-transfer protein; Provisional; Region: PRK08256 758793013337 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 758793013338 active site 758793013339 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 758793013340 active site 758793013341 catalytic site [active] 758793013342 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 758793013343 active site 758793013344 catalytic site [active] 758793013345 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793013346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793013347 NAD(P) binding site [chemical binding]; other site 758793013348 active site 758793013349 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 758793013350 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793013351 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793013352 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 758793013353 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793013354 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 758793013355 acyl-activating enzyme (AAE) consensus motif; other site 758793013356 acyl-activating enzyme (AAE) consensus motif; other site 758793013357 putative AMP binding site [chemical binding]; other site 758793013358 putative active site [active] 758793013359 putative CoA binding site [chemical binding]; other site 758793013360 enoyl-CoA hydratase; Provisional; Region: PRK09245 758793013361 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793013362 substrate binding site [chemical binding]; other site 758793013363 oxyanion hole (OAH) forming residues; other site 758793013364 trimer interface [polypeptide binding]; other site 758793013365 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793013366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793013367 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793013368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793013369 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793013370 active site 758793013371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793013372 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 758793013373 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 758793013374 acyl-activating enzyme (AAE) consensus motif; other site 758793013375 acyl-activating enzyme (AAE) consensus motif; other site 758793013376 putative AMP binding site [chemical binding]; other site 758793013377 putative active site [active] 758793013378 putative CoA binding site [chemical binding]; other site 758793013379 CoA binding site [chemical binding]; other site 758793013380 short chain dehydrogenase; Provisional; Region: PRK07791 758793013381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793013382 NAD(P) binding site [chemical binding]; other site 758793013383 active site 758793013384 lipid-transfer protein; Provisional; Region: PRK08256 758793013385 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 758793013386 active site 758793013387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793013388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793013389 active site 758793013390 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 758793013391 AAA ATPase domain; Region: AAA_16; pfam13191 758793013392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793013393 DNA binding residues [nucleotide binding] 758793013394 dimerization interface [polypeptide binding]; other site 758793013395 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 758793013396 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758793013397 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793013398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793013399 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 758793013400 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793013401 enoyl-CoA hydratase; Provisional; Region: PRK05870 758793013402 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793013403 substrate binding site [chemical binding]; other site 758793013404 oxyanion hole (OAH) forming residues; other site 758793013405 trimer interface [polypeptide binding]; other site 758793013406 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 758793013407 Isochorismatase family; Region: Isochorismatase; pfam00857 758793013408 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 758793013409 catalytic triad [active] 758793013410 conserved cis-peptide bond; other site 758793013411 Helix-turn-helix domain; Region: HTH_17; pfam12728 758793013412 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 758793013413 Citrate synthase; Region: Citrate_synt; pfam00285 758793013414 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 758793013415 dimer interface [polypeptide binding]; other site 758793013416 active site 758793013417 oxalacetate/citrate binding site [chemical binding]; other site 758793013418 citrylCoA binding site [chemical binding]; other site 758793013419 coenzyme A binding site [chemical binding]; other site 758793013420 catalytic triad [active] 758793013421 benzoate transport; Region: 2A0115; TIGR00895 758793013422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013423 putative substrate translocation pore; other site 758793013424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013425 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 758793013426 active site 758793013427 intersubunit interface [polypeptide binding]; other site 758793013428 Zn2+ binding site [ion binding]; other site 758793013429 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793013430 Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851 758793013431 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 758793013432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793013433 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 758793013434 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793013435 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793013436 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793013437 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793013438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793013439 Walker A/P-loop; other site 758793013440 ATP binding site [chemical binding]; other site 758793013441 Q-loop/lid; other site 758793013442 ABC transporter signature motif; other site 758793013443 Walker B; other site 758793013444 D-loop; other site 758793013445 H-loop/switch region; other site 758793013446 TOBE domain; Region: TOBE_2; pfam08402 758793013447 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 758793013448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793013449 dimer interface [polypeptide binding]; other site 758793013450 conserved gate region; other site 758793013451 putative PBP binding loops; other site 758793013452 ABC-ATPase subunit interface; other site 758793013453 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793013454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793013455 dimer interface [polypeptide binding]; other site 758793013456 conserved gate region; other site 758793013457 putative PBP binding loops; other site 758793013458 ABC-ATPase subunit interface; other site 758793013459 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 758793013460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758793013461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793013462 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758793013463 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793013464 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793013465 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 758793013466 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758793013467 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793013468 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793013469 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793013470 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793013471 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 758793013472 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793013473 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 758793013474 hydrophobic ligand binding site; other site 758793013475 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793013476 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 758793013477 FMN-binding pocket [chemical binding]; other site 758793013478 flavin binding motif; other site 758793013479 phosphate binding motif [ion binding]; other site 758793013480 beta-alpha-beta structure motif; other site 758793013481 NAD binding pocket [chemical binding]; other site 758793013482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793013483 catalytic loop [active] 758793013484 iron binding site [ion binding]; other site 758793013485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013486 D-galactonate transporter; Region: 2A0114; TIGR00893 758793013487 putative substrate translocation pore; other site 758793013488 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793013489 MarR family; Region: MarR; pfam01047 758793013490 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793013491 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 758793013492 NAD(P) binding site [chemical binding]; other site 758793013493 active site 758793013494 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793013495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013496 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793013497 dimerization interface [polypeptide binding]; other site 758793013498 substrate binding pocket [chemical binding]; other site 758793013499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013500 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 758793013501 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 758793013502 drug efflux system protein MdtG; Provisional; Region: PRK09874 758793013503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013504 putative substrate translocation pore; other site 758793013505 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 758793013506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013507 putative substrate translocation pore; other site 758793013508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013510 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 758793013511 putative effector binding pocket; other site 758793013512 putative dimerization interface [polypeptide binding]; other site 758793013513 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 758793013514 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793013515 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 758793013516 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793013517 catalytic residues [active] 758793013518 osmolarity response regulator; Provisional; Region: ompR; PRK09468 758793013519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793013520 active site 758793013521 phosphorylation site [posttranslational modification] 758793013522 intermolecular recognition site; other site 758793013523 dimerization interface [polypeptide binding]; other site 758793013524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793013525 DNA binding site [nucleotide binding] 758793013526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793013527 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 758793013528 dimerization interface [polypeptide binding]; other site 758793013529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793013530 ATP binding site [chemical binding]; other site 758793013531 Mg2+ binding site [ion binding]; other site 758793013532 G-X-G motif; other site 758793013533 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 758793013534 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 758793013535 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793013536 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 758793013537 Ligand binding site; other site 758793013538 Putative Catalytic site; other site 758793013539 DXD motif; other site 758793013540 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758793013541 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758793013542 putative acyl-acceptor binding pocket; other site 758793013543 MltA-interacting protein MipA; Region: MipA; cl01504 758793013544 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793013545 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 758793013546 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793013547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793013548 NAD(P) binding site [chemical binding]; other site 758793013549 active site 758793013550 Phosphopantetheine attachment site; Region: PP-binding; cl09936 758793013551 Predicted membrane protein [Function unknown]; Region: COG4648 758793013552 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 758793013553 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793013554 acyl-activating enzyme (AAE) consensus motif; other site 758793013555 AMP binding site [chemical binding]; other site 758793013556 active site 758793013557 CoA binding site [chemical binding]; other site 758793013558 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 758793013559 active site 2 [active] 758793013560 dimer interface [polypeptide binding]; other site 758793013561 active site 1 [active] 758793013562 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 758793013563 putative acyl-acceptor binding pocket; other site 758793013564 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 758793013565 Predicted exporter [General function prediction only]; Region: COG4258 758793013566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 758793013567 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 758793013568 NodB motif; other site 758793013569 active site 758793013570 catalytic site [active] 758793013571 metal binding site [ion binding]; metal-binding site 758793013572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793013573 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 758793013574 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 758793013575 dimer interface [polypeptide binding]; other site 758793013576 active site 758793013577 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 758793013578 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 758793013579 putative active site 1 [active] 758793013580 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 758793013581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793013582 S-adenosylmethionine binding site [chemical binding]; other site 758793013583 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 758793013584 Predicted transcriptional regulators [Transcription]; Region: COG1695 758793013585 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 758793013586 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 758793013587 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 758793013588 FAD binding pocket [chemical binding]; other site 758793013589 FAD binding motif [chemical binding]; other site 758793013590 phosphate binding motif [ion binding]; other site 758793013591 NAD binding pocket [chemical binding]; other site 758793013592 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793013593 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 758793013594 tetramer interface [polypeptide binding]; other site 758793013595 active site 758793013596 Mg2+/Mn2+ binding site [ion binding]; other site 758793013597 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 758793013598 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 758793013599 substrate binding site [chemical binding]; other site 758793013600 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 758793013601 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 758793013602 substrate binding site [chemical binding]; other site 758793013603 ligand binding site [chemical binding]; other site 758793013604 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793013605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793013606 dimer interface [polypeptide binding]; other site 758793013607 conserved gate region; other site 758793013608 putative PBP binding loops; other site 758793013609 ABC-ATPase subunit interface; other site 758793013610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793013611 dimer interface [polypeptide binding]; other site 758793013612 conserved gate region; other site 758793013613 putative PBP binding loops; other site 758793013614 ABC-ATPase subunit interface; other site 758793013615 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793013616 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793013617 Walker A/P-loop; other site 758793013618 ATP binding site [chemical binding]; other site 758793013619 Q-loop/lid; other site 758793013620 ABC transporter signature motif; other site 758793013621 Walker B; other site 758793013622 D-loop; other site 758793013623 H-loop/switch region; other site 758793013624 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 758793013625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 758793013626 membrane-bound complex binding site; other site 758793013627 hinge residues; other site 758793013628 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793013629 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793013630 DNA-binding site [nucleotide binding]; DNA binding site 758793013631 FCD domain; Region: FCD; pfam07729 758793013632 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793013633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793013634 DNA-binding site [nucleotide binding]; DNA binding site 758793013635 FCD domain; Region: FCD; pfam07729 758793013636 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 758793013637 Ligand Binding Site [chemical binding]; other site 758793013638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013640 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 758793013641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013642 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 758793013643 putative dimerization interface [polypeptide binding]; other site 758793013644 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 758793013645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793013646 S-adenosylmethionine binding site [chemical binding]; other site 758793013647 RNA polymerase sigma factor; Provisional; Region: PRK12547 758793013648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793013649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793013650 DNA binding residues [nucleotide binding] 758793013651 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 758793013652 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 758793013653 Sulfate transporter family; Region: Sulfate_transp; pfam00916 758793013654 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 758793013655 active site clefts [active] 758793013656 zinc binding site [ion binding]; other site 758793013657 dimer interface [polypeptide binding]; other site 758793013658 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793013659 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 758793013660 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 758793013661 putative active site [active] 758793013662 putative metal binding site [ion binding]; other site 758793013663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793013664 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793013665 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793013666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793013667 DNA-binding site [nucleotide binding]; DNA binding site 758793013668 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758793013669 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 758793013670 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758793013671 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758793013672 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 758793013673 Uncharacterized conserved protein [Function unknown]; Region: COG1434 758793013674 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 758793013675 putative active site [active] 758793013676 acyl carrier protein; Provisional; Region: PRK07081 758793013677 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793013678 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793013679 active site 758793013680 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793013681 active site 758793013682 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 758793013683 dimer interface [polypeptide binding]; other site 758793013684 motif 1; other site 758793013685 active site 758793013686 motif 2; other site 758793013687 motif 3; other site 758793013688 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 758793013689 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 758793013690 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793013691 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793013692 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758793013693 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 758793013694 inhibitor site; inhibition site 758793013695 active site 758793013696 dimer interface [polypeptide binding]; other site 758793013697 catalytic residue [active] 758793013698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013699 D-galactonate transporter; Region: 2A0114; TIGR00893 758793013700 putative substrate translocation pore; other site 758793013701 dihydroxy-acid dehydratase; Validated; Region: PRK06131 758793013702 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 758793013703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013704 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 758793013705 putative dimerization interface [polypeptide binding]; other site 758793013706 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 758793013707 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 758793013708 dimer interface [polypeptide binding]; other site 758793013709 PYR/PP interface [polypeptide binding]; other site 758793013710 TPP binding site [chemical binding]; other site 758793013711 substrate binding site [chemical binding]; other site 758793013712 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 758793013713 TPP-binding site; other site 758793013714 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 758793013715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013717 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 758793013718 putative substrate binding pocket [chemical binding]; other site 758793013719 dimerization interface [polypeptide binding]; other site 758793013720 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793013721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013723 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793013724 putative effector binding pocket; other site 758793013725 dimerization interface [polypeptide binding]; other site 758793013726 glutathionine S-transferase; Provisional; Region: PRK10542 758793013727 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793013728 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793013729 N-terminal domain interface [polypeptide binding]; other site 758793013730 dimer interface [polypeptide binding]; other site 758793013731 substrate binding pocket (H-site) [chemical binding]; other site 758793013732 Deoxyhypusine synthase; Region: DS; cl00826 758793013733 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 758793013734 Deoxyhypusine synthase; Region: DS; cl00826 758793013735 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793013736 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793013737 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793013738 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793013739 Predicted thioesterase [General function prediction only]; Region: COG5496 758793013740 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 758793013741 DctM-like transporters; Region: DctM; pfam06808 758793013742 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 758793013743 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 758793013744 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 758793013745 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793013746 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793013747 enoyl-CoA hydratase; Provisional; Region: PRK06127 758793013748 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793013749 substrate binding site [chemical binding]; other site 758793013750 oxyanion hole (OAH) forming residues; other site 758793013751 trimer interface [polypeptide binding]; other site 758793013752 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 758793013753 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 758793013754 putative active site [active] 758793013755 metal binding site [ion binding]; metal-binding site 758793013756 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013758 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793013759 dimerization interface [polypeptide binding]; other site 758793013760 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 758793013761 trimer interface [polypeptide binding]; other site 758793013762 putative Zn binding site [ion binding]; other site 758793013763 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793013766 dimerization interface [polypeptide binding]; other site 758793013767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793013768 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793013769 active site 758793013770 catalytic tetrad [active] 758793013771 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 758793013772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013773 putative substrate translocation pore; other site 758793013774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013775 BON domain; Region: BON; pfam04972 758793013776 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758793013777 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 758793013778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793013779 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793013780 substrate binding pocket [chemical binding]; other site 758793013781 membrane-bound complex binding site; other site 758793013782 hinge residues; other site 758793013783 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793013784 DNA-binding site [nucleotide binding]; DNA binding site 758793013785 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793013786 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793013787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793013788 homodimer interface [polypeptide binding]; other site 758793013789 catalytic residue [active] 758793013790 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 758793013791 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 758793013792 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 758793013793 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 758793013794 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793013795 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793013796 metal binding site [ion binding]; metal-binding site 758793013797 active site 758793013798 I-site; other site 758793013799 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793013800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013802 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 758793013803 putative dimerization interface [polypeptide binding]; other site 758793013804 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793013805 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 758793013806 inhibitor-cofactor binding pocket; inhibition site 758793013807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793013808 catalytic residue [active] 758793013809 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 758793013810 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 758793013811 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793013812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793013814 dimerization interface [polypeptide binding]; other site 758793013815 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 758793013816 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793013817 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 758793013818 Fusaric acid resistance protein family; Region: FUSC; pfam04632 758793013819 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793013820 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 758793013821 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 758793013822 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793013823 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793013824 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793013825 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 758793013826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793013827 DNA-binding site [nucleotide binding]; DNA binding site 758793013828 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758793013829 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 758793013830 FAD binding domain; Region: FAD_binding_4; pfam01565 758793013831 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 758793013832 FAD binding domain; Region: FAD_binding_4; pfam01565 758793013833 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 758793013834 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758793013835 Cysteine-rich domain; Region: CCG; pfam02754 758793013836 Cysteine-rich domain; Region: CCG; pfam02754 758793013837 Fusaric acid resistance protein family; Region: FUSC; pfam04632 758793013838 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793013839 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 758793013840 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793013841 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793013842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 758793013843 SnoaL-like domain; Region: SnoaL_2; pfam12680 758793013844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793013845 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793013846 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 758793013847 benzoate transport; Region: 2A0115; TIGR00895 758793013848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013849 putative substrate translocation pore; other site 758793013850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013851 putative substrate translocation pore; other site 758793013852 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 758793013853 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 758793013854 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 758793013855 octamer interface [polypeptide binding]; other site 758793013856 active site 758793013857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013859 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 758793013860 dimerizarion interface [polypeptide binding]; other site 758793013861 CrgA pocket; other site 758793013862 substrate binding pocket [chemical binding]; other site 758793013863 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 758793013864 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 758793013865 dimer interface [polypeptide binding]; other site 758793013866 active site 758793013867 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 758793013868 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 758793013869 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 758793013870 putative alpha subunit interface [polypeptide binding]; other site 758793013871 putative active site [active] 758793013872 putative substrate binding site [chemical binding]; other site 758793013873 Fe binding site [ion binding]; other site 758793013874 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 758793013875 inter-subunit interface; other site 758793013876 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 758793013877 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793013878 catalytic loop [active] 758793013879 iron binding site [ion binding]; other site 758793013880 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 758793013881 FAD binding pocket [chemical binding]; other site 758793013882 FAD binding motif [chemical binding]; other site 758793013883 phosphate binding motif [ion binding]; other site 758793013884 beta-alpha-beta structure motif; other site 758793013885 NAD binding pocket [chemical binding]; other site 758793013886 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 758793013887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793013888 NAD(P) binding site [chemical binding]; other site 758793013889 active site 758793013890 HdeA/HdeB family; Region: HdeA; cl05752 758793013891 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 758793013892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013893 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 758793013894 putative dimerization interface [polypeptide binding]; other site 758793013895 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 758793013896 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 758793013897 THF binding site; other site 758793013898 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 758793013899 substrate binding site [chemical binding]; other site 758793013900 THF binding site; other site 758793013901 zinc-binding site [ion binding]; other site 758793013902 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793013903 GAF domain; Region: GAF; pfam01590 758793013904 PAS fold; Region: PAS_4; pfam08448 758793013905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793013906 PAS fold; Region: PAS_3; pfam08447 758793013907 putative active site [active] 758793013908 heme pocket [chemical binding]; other site 758793013909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793013910 ATP binding site [chemical binding]; other site 758793013911 Mg2+ binding site [ion binding]; other site 758793013912 G-X-G motif; other site 758793013913 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793013914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793013915 active site 758793013916 phosphorylation site [posttranslational modification] 758793013917 intermolecular recognition site; other site 758793013918 dimerization interface [polypeptide binding]; other site 758793013919 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 758793013920 dimer interface [polypeptide binding]; other site 758793013921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793013922 GAF domain; Region: GAF_3; pfam13492 758793013923 GAF domain; Region: GAF_2; pfam13185 758793013924 HWE histidine kinase; Region: HWE_HK; cl06527 758793013925 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 758793013926 ATP binding site [chemical binding]; other site 758793013927 Mg2+ binding site [ion binding]; other site 758793013928 G-X-G motif; other site 758793013929 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793013930 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793013931 metal binding site [ion binding]; metal-binding site 758793013932 active site 758793013933 I-site; other site 758793013934 putative hydrolase; Provisional; Region: PRK11460 758793013935 hypothetical protein; Provisional; Region: PRK07236 758793013936 hypothetical protein; Validated; Region: PRK05868 758793013937 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793013938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793013939 WHG domain; Region: WHG; pfam13305 758793013940 PAS domain; Region: PAS; smart00091 758793013941 PAS fold; Region: PAS_4; pfam08448 758793013942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793013943 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 758793013944 Walker A motif; other site 758793013945 ATP binding site [chemical binding]; other site 758793013946 Walker B motif; other site 758793013947 arginine finger; other site 758793013948 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793013949 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793013950 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 758793013951 dimerization interface [polypeptide binding]; other site 758793013952 ligand binding site [chemical binding]; other site 758793013953 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 758793013954 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 758793013955 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 758793013956 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793013957 substrate binding site [chemical binding]; other site 758793013958 oxyanion hole (OAH) forming residues; other site 758793013959 trimer interface [polypeptide binding]; other site 758793013960 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 758793013961 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793013962 acyl-activating enzyme (AAE) consensus motif; other site 758793013963 AMP binding site [chemical binding]; other site 758793013964 active site 758793013965 CoA binding site [chemical binding]; other site 758793013966 Predicted thioesterase [General function prediction only]; Region: COG5496 758793013967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793013968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793013969 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 758793013970 putative effector binding pocket; other site 758793013971 putative dimerization interface [polypeptide binding]; other site 758793013972 short chain dehydrogenase; Provisional; Region: PRK06500 758793013973 classical (c) SDRs; Region: SDR_c; cd05233 758793013974 NAD(P) binding site [chemical binding]; other site 758793013975 active site 758793013976 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 758793013977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793013978 NAD(P) binding site [chemical binding]; other site 758793013979 active site 758793013980 Deoxyhypusine synthase; Region: DS; cl00826 758793013981 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 758793013982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793013983 FeS/SAM binding site; other site 758793013984 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 758793013985 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 758793013986 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 758793013987 putative molybdopterin cofactor binding site [chemical binding]; other site 758793013988 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 758793013989 putative molybdopterin cofactor binding site; other site 758793013990 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 758793013991 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 758793013992 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 758793013993 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 758793013994 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 758793013995 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 758793013996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793013997 putative substrate translocation pore; other site 758793013998 SnoaL-like domain; Region: SnoaL_2; pfam12680 758793013999 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793014000 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793014001 active site 758793014002 catalytic tetrad [active] 758793014003 Epoxide hydrolase N terminus; Region: EHN; pfam06441 758793014004 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793014005 BON domain; Region: BON; pfam04972 758793014006 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 758793014007 Catalytic domain of Protein Kinases; Region: PKc; cd00180 758793014008 substrate binding site [chemical binding]; other site 758793014009 activation loop (A-loop); other site 758793014010 AAA ATPase domain; Region: AAA_16; pfam13191 758793014011 Predicted ATPase [General function prediction only]; Region: COG3899 758793014012 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793014013 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 758793014014 PAS fold; Region: PAS; pfam00989 758793014015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793014016 putative active site [active] 758793014017 heme pocket [chemical binding]; other site 758793014018 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 758793014019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793014020 dimer interface [polypeptide binding]; other site 758793014021 phosphorylation site [posttranslational modification] 758793014022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793014023 ATP binding site [chemical binding]; other site 758793014024 G-X-G motif; other site 758793014025 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 758793014026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793014027 substrate binding site [chemical binding]; other site 758793014028 oxyanion hole (OAH) forming residues; other site 758793014029 trimer interface [polypeptide binding]; other site 758793014030 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 758793014031 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 758793014032 potential catalytic triad [active] 758793014033 conserved cys residue [active] 758793014034 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 758793014035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793014036 active site 758793014037 phosphorylation site [posttranslational modification] 758793014038 intermolecular recognition site; other site 758793014039 dimerization interface [polypeptide binding]; other site 758793014040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793014041 DNA binding residues [nucleotide binding] 758793014042 dimerization interface [polypeptide binding]; other site 758793014043 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 758793014044 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793014045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793014046 putative DNA binding site [nucleotide binding]; other site 758793014047 dimerization interface [polypeptide binding]; other site 758793014048 putative Zn2+ binding site [ion binding]; other site 758793014049 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 758793014050 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 758793014051 PYR/PP interface [polypeptide binding]; other site 758793014052 dimer interface [polypeptide binding]; other site 758793014053 TPP binding site [chemical binding]; other site 758793014054 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 758793014055 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 758793014056 TPP-binding site [chemical binding]; other site 758793014057 dimer interface [polypeptide binding]; other site 758793014058 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793014059 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793014060 conserved cys residue [active] 758793014061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014063 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 758793014064 active site 758793014065 SUMO-1 interface [polypeptide binding]; other site 758793014066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014068 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 758793014069 putative effector binding pocket; other site 758793014070 putative dimerization interface [polypeptide binding]; other site 758793014071 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 758793014072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014073 putative substrate translocation pore; other site 758793014074 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 758793014075 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793014076 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793014077 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793014078 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 758793014079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793014081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014082 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793014083 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793014084 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793014085 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793014086 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793014087 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793014088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793014089 Transposase-associated domain; Region: Transpos_assoc; pfam13963 758793014090 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 758793014091 Uncharacterized conserved protein [Function unknown]; Region: COG1432 758793014092 NYN domain; Region: NYN; pfam01936 758793014093 putative metal binding site [ion binding]; other site 758793014094 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 758793014095 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 758793014096 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 758793014097 Helix-turn-helix domain; Region: HTH_18; pfam12833 758793014098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014099 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 758793014100 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 758793014101 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 758793014102 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793014103 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793014104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793014106 dimerization interface [polypeptide binding]; other site 758793014107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 758793014108 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 758793014109 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 758793014110 dimer interface [polypeptide binding]; other site 758793014111 active site 758793014112 catalytic residue [active] 758793014113 metal binding site [ion binding]; metal-binding site 758793014114 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 758793014115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014116 putative substrate translocation pore; other site 758793014117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 758793014118 citrate-proton symporter; Provisional; Region: PRK15075 758793014119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014120 putative substrate translocation pore; other site 758793014121 hypothetical protein; Provisional; Region: PRK07079 758793014122 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 758793014123 metal binding site [ion binding]; metal-binding site 758793014124 putative dimer interface [polypeptide binding]; other site 758793014125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793014128 dimerization interface [polypeptide binding]; other site 758793014129 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 758793014130 putative dimer interface [polypeptide binding]; other site 758793014131 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 758793014132 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 758793014133 active site 758793014134 nucleophile elbow; other site 758793014135 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 758793014136 Patatin phospholipase; Region: DUF3734; pfam12536 758793014137 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 758793014138 classical (c) SDRs; Region: SDR_c; cd05233 758793014139 NAD(P) binding site [chemical binding]; other site 758793014140 active site 758793014141 acetoacetate decarboxylase; Provisional; Region: PRK02265 758793014142 short chain dehydrogenase; Provisional; Region: PRK06180 758793014143 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 758793014144 NADP binding site [chemical binding]; other site 758793014145 active site 758793014146 steroid binding site; other site 758793014147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793014148 dimer interface [polypeptide binding]; other site 758793014149 conserved gate region; other site 758793014150 ABC-ATPase subunit interface; other site 758793014151 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 758793014152 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 758793014153 Walker A/P-loop; other site 758793014154 ATP binding site [chemical binding]; other site 758793014155 Q-loop/lid; other site 758793014156 ABC transporter signature motif; other site 758793014157 Walker B; other site 758793014158 D-loop; other site 758793014159 H-loop/switch region; other site 758793014160 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 758793014161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793014162 dimer interface [polypeptide binding]; other site 758793014163 conserved gate region; other site 758793014164 putative PBP binding loops; other site 758793014165 ABC-ATPase subunit interface; other site 758793014166 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 758793014167 Predicted amidohydrolase [General function prediction only]; Region: COG0388 758793014168 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 758793014169 putative active site [active] 758793014170 catalytic triad [active] 758793014171 putative dimer interface [polypeptide binding]; other site 758793014172 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793014173 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 758793014174 active site 758793014175 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 758793014176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793014177 acyl-activating enzyme (AAE) consensus motif; other site 758793014178 AMP binding site [chemical binding]; other site 758793014179 active site 758793014180 CoA binding site [chemical binding]; other site 758793014181 enoyl-CoA hydratase; Provisional; Region: PRK09245 758793014182 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793014183 substrate binding site [chemical binding]; other site 758793014184 oxyanion hole (OAH) forming residues; other site 758793014185 trimer interface [polypeptide binding]; other site 758793014186 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 758793014187 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793014188 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 758793014189 conserved cys residue [active] 758793014190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014191 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793014192 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793014193 trimer interface [polypeptide binding]; other site 758793014194 eyelet of channel; other site 758793014195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793014196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793014197 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 758793014198 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 758793014199 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 758793014200 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 758793014201 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793014202 motif II; other site 758793014203 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 758793014204 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 758793014205 CGNR zinc finger; Region: zf-CGNR; pfam11706 758793014206 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793014207 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 758793014208 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 758793014209 putative NAD(P) binding site [chemical binding]; other site 758793014210 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 758793014211 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 758793014212 putative NAD(P) binding site [chemical binding]; other site 758793014213 putative active site [active] 758793014214 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 758793014215 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 758793014216 Moco binding site; other site 758793014217 metal coordination site [ion binding]; other site 758793014218 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 758793014219 RNA polymerase sigma factor; Provisional; Region: PRK12536 758793014220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793014221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793014222 DNA binding residues [nucleotide binding] 758793014223 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 758793014224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793014225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793014226 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793014227 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 758793014228 C-terminal domain interface [polypeptide binding]; other site 758793014229 GSH binding site (G-site) [chemical binding]; other site 758793014230 dimer interface [polypeptide binding]; other site 758793014231 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793014232 N-terminal domain interface [polypeptide binding]; other site 758793014233 dimer interface [polypeptide binding]; other site 758793014234 substrate binding pocket (H-site) [chemical binding]; other site 758793014235 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 758793014236 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 758793014237 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 758793014238 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 758793014239 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 758793014240 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758793014241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793014242 DNA-binding site [nucleotide binding]; DNA binding site 758793014243 UTRA domain; Region: UTRA; pfam07702 758793014244 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 758793014245 MEKHLA domain; Region: MEKHLA; pfam08670 758793014246 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 758793014247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793014248 NAD(P) binding site [chemical binding]; other site 758793014249 active site 758793014250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014252 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793014253 putative effector binding pocket; other site 758793014254 dimerization interface [polypeptide binding]; other site 758793014255 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 758793014256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793014257 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793014258 active site 758793014259 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 758793014260 succinic semialdehyde dehydrogenase; Region: PLN02278 758793014261 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 758793014262 tetramerization interface [polypeptide binding]; other site 758793014263 NAD(P) binding site [chemical binding]; other site 758793014264 catalytic residues [active] 758793014265 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 758793014266 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 758793014267 Na binding site [ion binding]; other site 758793014268 Protein of unknown function, DUF485; Region: DUF485; pfam04341 758793014269 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793014270 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793014271 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793014272 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793014273 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793014274 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 758793014275 Paraquat-inducible protein A; Region: PqiA; pfam04403 758793014276 Paraquat-inducible protein A; Region: PqiA; pfam04403 758793014277 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 758793014278 mce related protein; Region: MCE; pfam02470 758793014279 mce related protein; Region: MCE; pfam02470 758793014280 mce related protein; Region: MCE; pfam02470 758793014281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 758793014282 Protein of unknown function (DUF330); Region: DUF330; pfam03886 758793014283 propionate/acetate kinase; Provisional; Region: PRK12379 758793014284 Acetokinase family; Region: Acetate_kinase; cl17229 758793014285 phosphate acetyltransferase; Provisional; Region: PRK11890 758793014286 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 758793014287 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 758793014288 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 758793014289 Sulfate transporter family; Region: Sulfate_transp; pfam00916 758793014290 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 758793014291 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 758793014292 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cd00590 758793014293 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 758793014294 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 758793014295 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 758793014296 putative ligand binding site [chemical binding]; other site 758793014297 putative NAD binding site [chemical binding]; other site 758793014298 catalytic site [active] 758793014299 Predicted permease [General function prediction only]; Region: COG2985 758793014300 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 758793014301 TrkA-C domain; Region: TrkA_C; pfam02080 758793014302 TrkA-C domain; Region: TrkA_C; pfam02080 758793014303 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 758793014304 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793014305 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793014306 allantoate amidohydrolase; Reviewed; Region: PRK12893 758793014307 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 758793014308 active site 758793014309 metal binding site [ion binding]; metal-binding site 758793014310 dimer interface [polypeptide binding]; other site 758793014311 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793014312 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793014313 conserved cys residue [active] 758793014314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014315 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 758793014316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793014317 NAD(P) binding site [chemical binding]; other site 758793014318 active site 758793014319 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 758793014320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793014323 dimerization interface [polypeptide binding]; other site 758793014324 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793014325 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793014326 pyruvate kinase; Provisional; Region: PRK06247 758793014327 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 758793014328 domain interfaces; other site 758793014329 active site 758793014330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014331 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 758793014332 putative effector binding pocket; other site 758793014333 putative dimerization interface [polypeptide binding]; other site 758793014334 transcriptional activator TtdR; Provisional; Region: PRK09801 758793014335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014336 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 758793014337 putative effector binding pocket; other site 758793014338 putative dimerization interface [polypeptide binding]; other site 758793014339 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793014340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014341 putative substrate translocation pore; other site 758793014342 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 758793014343 active site clefts [active] 758793014344 zinc binding site [ion binding]; other site 758793014345 dimer interface [polypeptide binding]; other site 758793014346 Predicted amidohydrolase [General function prediction only]; Region: COG0388 758793014347 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 758793014348 putative active site [active] 758793014349 catalytic triad [active] 758793014350 putative dimer interface [polypeptide binding]; other site 758793014351 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793014352 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793014353 conserved cys residue [active] 758793014354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793014355 short chain dehydrogenase; Provisional; Region: PRK06172 758793014356 classical (c) SDRs; Region: SDR_c; cd05233 758793014357 NAD(P) binding site [chemical binding]; other site 758793014358 active site 758793014359 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793014360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793014361 NAD(P) binding site [chemical binding]; other site 758793014362 active site 758793014363 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 758793014364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793014366 dimerization interface [polypeptide binding]; other site 758793014367 galactarate dehydratase; Region: galactar-dH20; TIGR03248 758793014368 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 758793014369 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 758793014370 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 758793014371 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758793014372 putative active site [active] 758793014373 catalytic residue [active] 758793014374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014375 D-galactonate transporter; Region: 2A0114; TIGR00893 758793014376 putative substrate translocation pore; other site 758793014377 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 758793014378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 758793014379 MOSC domain; Region: MOSC; pfam03473 758793014380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793014381 Coenzyme A binding pocket [chemical binding]; other site 758793014382 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 758793014383 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793014384 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793014385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793014386 DNA-binding site [nucleotide binding]; DNA binding site 758793014387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793014388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793014389 homodimer interface [polypeptide binding]; other site 758793014390 catalytic residue [active] 758793014391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793014392 NADH(P)-binding; Region: NAD_binding_10; pfam13460 758793014393 NAD(P) binding site [chemical binding]; other site 758793014394 active site 758793014395 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793014396 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793014397 trimer interface [polypeptide binding]; other site 758793014398 eyelet of channel; other site 758793014399 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 758793014400 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 758793014401 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793014402 Uncharacterized conserved protein [Function unknown]; Region: COG5476 758793014403 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 758793014404 MlrC C-terminus; Region: MlrC_C; pfam07171 758793014405 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793014406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014407 putative substrate translocation pore; other site 758793014408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793014411 dimerization interface [polypeptide binding]; other site 758793014412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014413 H+ Antiporter protein; Region: 2A0121; TIGR00900 758793014414 putative substrate translocation pore; other site 758793014415 PAS fold; Region: PAS_4; pfam08448 758793014416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793014417 PAS fold; Region: PAS_3; pfam08447 758793014418 putative active site [active] 758793014419 heme pocket [chemical binding]; other site 758793014420 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793014421 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793014422 metal binding site [ion binding]; metal-binding site 758793014423 active site 758793014424 I-site; other site 758793014425 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793014426 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 758793014427 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 758793014428 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793014429 active site 758793014430 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758793014431 Tar ligand binding domain homologue; Region: TarH; pfam02203 758793014432 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758793014433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793014434 dimerization interface [polypeptide binding]; other site 758793014435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793014436 dimer interface [polypeptide binding]; other site 758793014437 putative CheW interface [polypeptide binding]; other site 758793014438 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014439 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014440 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793014441 dimerization interface [polypeptide binding]; other site 758793014442 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 758793014443 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 758793014444 active site 758793014445 FMN binding site [chemical binding]; other site 758793014446 substrate binding site [chemical binding]; other site 758793014447 homotetramer interface [polypeptide binding]; other site 758793014448 catalytic residue [active] 758793014449 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 758793014450 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 758793014451 hypothetical protein; Provisional; Region: PRK09262 758793014452 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793014453 benzoate transport; Region: 2A0115; TIGR00895 758793014454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014455 putative substrate translocation pore; other site 758793014456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014457 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 758793014458 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 758793014459 active site 758793014460 metal binding site [ion binding]; metal-binding site 758793014461 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 758793014462 putative dimer interface [polypeptide binding]; other site 758793014463 putative N- and C-terminal domain interface [polypeptide binding]; other site 758793014464 Predicted ester cyclase [General function prediction only]; Region: COG5485 758793014465 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793014466 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793014467 Walker A/P-loop; other site 758793014468 ATP binding site [chemical binding]; other site 758793014469 Q-loop/lid; other site 758793014470 ABC transporter signature motif; other site 758793014471 Walker B; other site 758793014472 D-loop; other site 758793014473 H-loop/switch region; other site 758793014474 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793014475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793014476 putative PBP binding loops; other site 758793014477 ABC-ATPase subunit interface; other site 758793014478 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793014479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793014480 conserved gate region; other site 758793014481 dimer interface [polypeptide binding]; other site 758793014482 putative PBP binding loops; other site 758793014483 ABC-ATPase subunit interface; other site 758793014484 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 758793014485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793014486 substrate binding pocket [chemical binding]; other site 758793014487 membrane-bound complex binding site; other site 758793014488 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 758793014489 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 758793014490 active site 758793014491 iron coordination sites [ion binding]; other site 758793014492 substrate binding pocket [chemical binding]; other site 758793014493 Nitronate monooxygenase; Region: NMO; pfam03060 758793014494 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 758793014495 FMN binding site [chemical binding]; other site 758793014496 substrate binding site [chemical binding]; other site 758793014497 putative catalytic residue [active] 758793014498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014500 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793014501 putative effector binding pocket; other site 758793014502 dimerization interface [polypeptide binding]; other site 758793014503 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 758793014504 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 758793014505 tetrameric interface [polypeptide binding]; other site 758793014506 NAD binding site [chemical binding]; other site 758793014507 catalytic residues [active] 758793014508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014510 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793014511 putative effector binding pocket; other site 758793014512 dimerization interface [polypeptide binding]; other site 758793014513 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793014514 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 758793014515 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 758793014516 catalytic residue [active] 758793014517 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 758793014518 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793014519 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 758793014520 catalytic site [active] 758793014521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793014524 dimerization interface [polypeptide binding]; other site 758793014525 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 758793014526 active site lid residues [active] 758793014527 substrate binding pocket [chemical binding]; other site 758793014528 catalytic residues [active] 758793014529 substrate-Mg2+ binding site; other site 758793014530 aspartate-rich region 1; other site 758793014531 aspartate-rich region 2; other site 758793014532 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 758793014533 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 758793014534 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 758793014535 active site 758793014536 tetramer interface; other site 758793014537 Acyltransferase family; Region: Acyl_transf_3; pfam01757 758793014538 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 758793014539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793014540 putative ADP-binding pocket [chemical binding]; other site 758793014541 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793014542 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793014543 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 758793014544 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 758793014545 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 758793014546 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 758793014547 NADP-binding site; other site 758793014548 homotetramer interface [polypeptide binding]; other site 758793014549 substrate binding site [chemical binding]; other site 758793014550 homodimer interface [polypeptide binding]; other site 758793014551 active site 758793014552 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793014553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793014554 NAD(P) binding site [chemical binding]; other site 758793014555 active site 758793014556 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793014557 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793014558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793014559 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 758793014560 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 758793014561 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793014562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793014563 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 758793014564 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 758793014565 DXD motif; other site 758793014566 tyrosine kinase; Provisional; Region: PRK11519 758793014567 Chain length determinant protein; Region: Wzz; pfam02706 758793014568 Chain length determinant protein; Region: Wzz; cl15801 758793014569 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 758793014570 polysaccharide export protein Wza; Provisional; Region: PRK15078 758793014571 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 758793014572 SLBB domain; Region: SLBB; pfam10531 758793014573 SLBB domain; Region: SLBB; pfam10531 758793014574 Low molecular weight phosphatase family; Region: LMWPc; cd00115 758793014575 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 758793014576 active site 758793014577 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 758793014578 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 758793014579 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 758793014580 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 758793014581 Bacterial sugar transferase; Region: Bac_transf; pfam02397 758793014582 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 758793014583 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 758793014584 Substrate binding site; other site 758793014585 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 758793014586 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 758793014587 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 758793014588 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 758793014589 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793014590 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 758793014591 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793014592 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 758793014593 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793014594 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793014595 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 758793014596 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793014597 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 758793014598 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793014599 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793014600 hypothetical protein; Provisional; Region: PRK06847 758793014601 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 758793014602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793014603 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 758793014604 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 758793014605 Isochorismatase family; Region: Isochorismatase; pfam00857 758793014606 catalytic triad [active] 758793014607 conserved cis-peptide bond; other site 758793014608 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793014609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014610 putative substrate translocation pore; other site 758793014611 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793014612 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793014613 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793014614 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793014615 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 758793014616 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793014617 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 758793014618 C-terminal domain interface [polypeptide binding]; other site 758793014619 GSH binding site (G-site) [chemical binding]; other site 758793014620 dimer interface [polypeptide binding]; other site 758793014621 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 758793014622 N-terminal domain interface [polypeptide binding]; other site 758793014623 dimer interface [polypeptide binding]; other site 758793014624 substrate binding pocket (H-site) [chemical binding]; other site 758793014625 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793014626 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793014627 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793014628 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 758793014629 putative N-terminal domain interface [polypeptide binding]; other site 758793014630 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 758793014631 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 758793014632 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 758793014633 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 758793014634 putative NADH binding site [chemical binding]; other site 758793014635 putative active site [active] 758793014636 nudix motif; other site 758793014637 putative metal binding site [ion binding]; other site 758793014638 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 758793014639 catalytic core [active] 758793014640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793014641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793014642 DNA binding site [nucleotide binding] 758793014643 domain linker motif; other site 758793014644 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 758793014645 putative dimerization interface [polypeptide binding]; other site 758793014646 putative ligand binding site [chemical binding]; other site 758793014647 hypothetical protein; Validated; Region: PRK08245 758793014648 hypothetical protein; Validated; Region: PRK06201 758793014649 dihydroxy-acid dehydratase; Validated; Region: PRK06131 758793014650 MarC family integral membrane protein; Region: MarC; cl00919 758793014651 Flagellar regulator YcgR; Region: YcgR; pfam07317 758793014652 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 758793014653 PilZ domain; Region: PilZ; pfam07238 758793014654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793014655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793014656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793014657 DNA binding residues [nucleotide binding] 758793014658 dimerization interface [polypeptide binding]; other site 758793014659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793014660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793014661 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 758793014662 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 758793014663 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 758793014664 B12 binding site [chemical binding]; other site 758793014665 probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099 758793014666 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 758793014667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793014668 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 758793014669 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 758793014670 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 758793014671 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 758793014672 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 758793014673 dimerization interface [polypeptide binding]; other site 758793014674 putative ATP binding site [chemical binding]; other site 758793014675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793014676 Coenzyme A binding pocket [chemical binding]; other site 758793014677 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 758793014678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793014679 FeS/SAM binding site; other site 758793014680 Predicted amidohydrolase [General function prediction only]; Region: COG0388 758793014681 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 758793014682 putative active site [active] 758793014683 catalytic triad [active] 758793014684 putative dimer interface [polypeptide binding]; other site 758793014685 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 758793014686 Predicted transcriptional regulators [Transcription]; Region: COG1725 758793014687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 758793014688 DNA-binding site [nucleotide binding]; DNA binding site 758793014689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793014690 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 758793014691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793014692 homodimer interface [polypeptide binding]; other site 758793014693 catalytic residue [active] 758793014694 hypothetical protein; Provisional; Region: PRK09936 758793014695 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 758793014696 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 758793014697 active site 758793014698 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 758793014699 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 758793014700 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 758793014701 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 758793014702 active site 758793014703 homodimer interface [polypeptide binding]; other site 758793014704 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 758793014705 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793014706 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 758793014707 ArsC family; Region: ArsC; pfam03960 758793014708 catalytic residues [active] 758793014709 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793014710 Coenzyme A binding pocket [chemical binding]; other site 758793014711 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 758793014712 arsenical-resistance protein; Region: acr3; TIGR00832 758793014713 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 758793014714 Low molecular weight phosphatase family; Region: LMWPc; cl00105 758793014715 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 758793014716 putative metal binding site [ion binding]; other site 758793014717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793014718 putative DNA binding site [nucleotide binding]; other site 758793014719 putative Zn2+ binding site [ion binding]; other site 758793014720 benzoate transport; Region: 2A0115; TIGR00895 758793014721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014722 putative substrate translocation pore; other site 758793014723 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793014724 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 758793014725 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 758793014726 Citrate transporter; Region: CitMHS; pfam03600 758793014727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793014728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793014729 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 758793014730 putative dimerization interface [polypeptide binding]; other site 758793014731 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 758793014732 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 758793014733 putative NAD(P) binding site [chemical binding]; other site 758793014734 putative substrate binding site [chemical binding]; other site 758793014735 catalytic Zn binding site [ion binding]; other site 758793014736 structural Zn binding site [ion binding]; other site 758793014737 dimer interface [polypeptide binding]; other site 758793014738 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 758793014739 active site 758793014740 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 758793014741 NapD protein; Region: NapD; pfam03927 758793014742 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 758793014743 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 758793014744 [4Fe-4S] binding site [ion binding]; other site 758793014745 molybdopterin cofactor binding site; other site 758793014746 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 758793014747 molybdopterin cofactor binding site; other site 758793014748 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 758793014749 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 758793014750 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 758793014751 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 758793014752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793014753 Walker A/P-loop; other site 758793014754 ATP binding site [chemical binding]; other site 758793014755 Q-loop/lid; other site 758793014756 ABC transporter signature motif; other site 758793014757 Walker B; other site 758793014758 D-loop; other site 758793014759 H-loop/switch region; other site 758793014760 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 758793014761 heme exporter protein CcmC; Region: ccmC; TIGR01191 758793014762 CcmE; Region: CcmE; pfam03100 758793014763 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 758793014764 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 758793014765 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793014766 catalytic residues [active] 758793014767 central insert; other site 758793014768 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 758793014769 Tetratricopeptide repeat; Region: TPR_2; pfam07719 758793014770 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 758793014771 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 758793014772 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 758793014773 FMN binding site [chemical binding]; other site 758793014774 substrate binding site [chemical binding]; other site 758793014775 putative catalytic residue [active] 758793014776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793014777 dimerization interface [polypeptide binding]; other site 758793014778 DNA binding residues [nucleotide binding] 758793014779 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 758793014780 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793014781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793014782 Walker A/P-loop; other site 758793014783 ATP binding site [chemical binding]; other site 758793014784 Q-loop/lid; other site 758793014785 ABC transporter signature motif; other site 758793014786 Walker B; other site 758793014787 D-loop; other site 758793014788 H-loop/switch region; other site 758793014789 TOBE domain; Region: TOBE_2; pfam08402 758793014790 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 758793014791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793014792 dimer interface [polypeptide binding]; other site 758793014793 conserved gate region; other site 758793014794 putative PBP binding loops; other site 758793014795 ABC-ATPase subunit interface; other site 758793014796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793014797 dimer interface [polypeptide binding]; other site 758793014798 conserved gate region; other site 758793014799 putative PBP binding loops; other site 758793014800 ABC-ATPase subunit interface; other site 758793014801 benzoate transport; Region: 2A0115; TIGR00895 758793014802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014803 putative substrate translocation pore; other site 758793014804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014805 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 758793014806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793014807 catalytic loop [active] 758793014808 iron binding site [ion binding]; other site 758793014809 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 758793014810 FAD binding pocket [chemical binding]; other site 758793014811 FAD binding motif [chemical binding]; other site 758793014812 phosphate binding motif [ion binding]; other site 758793014813 beta-alpha-beta structure motif; other site 758793014814 NAD binding pocket [chemical binding]; other site 758793014815 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 758793014816 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 758793014817 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 758793014818 inter-subunit interface; other site 758793014819 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793014820 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 758793014821 iron-sulfur cluster [ion binding]; other site 758793014822 [2Fe-2S] cluster binding site [ion binding]; other site 758793014823 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 758793014824 putative alpha subunit interface [polypeptide binding]; other site 758793014825 putative active site [active] 758793014826 putative substrate binding site [chemical binding]; other site 758793014827 Fe binding site [ion binding]; other site 758793014828 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 758793014829 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793014830 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793014831 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 758793014832 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 758793014833 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 758793014834 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 758793014835 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 758793014836 D-pathway; other site 758793014837 Putative ubiquinol binding site [chemical binding]; other site 758793014838 Low-spin heme (heme b) binding site [chemical binding]; other site 758793014839 Putative water exit pathway; other site 758793014840 Binuclear center (heme o3/CuB) [ion binding]; other site 758793014841 K-pathway; other site 758793014842 Putative proton exit pathway; other site 758793014843 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 758793014844 Subunit I/III interface [polypeptide binding]; other site 758793014845 Subunit III/IV interface [polypeptide binding]; other site 758793014846 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 758793014847 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 758793014848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793014849 D-galactonate transporter; Region: 2A0114; TIGR00893 758793014850 putative substrate translocation pore; other site 758793014851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793014852 NAD(P) binding site [chemical binding]; other site 758793014853 active site 758793014854 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793014855 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793014856 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793014857 ABC1 family; Region: ABC1; cl17513 758793014858 ABC1 family; Region: ABC1; cl17513 758793014859 Response regulator receiver domain; Region: Response_reg; pfam00072 758793014860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793014861 active site 758793014862 phosphorylation site [posttranslational modification] 758793014863 intermolecular recognition site; other site 758793014864 dimerization interface [polypeptide binding]; other site 758793014865 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 758793014866 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793014867 active site 758793014868 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793014869 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793014870 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 758793014871 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793014872 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 758793014873 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793014874 ligand binding site [chemical binding]; other site 758793014875 Domain of unknown function DUF302; Region: DUF302; pfam03625 758793014876 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 758793014877 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 758793014878 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 758793014879 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 758793014880 nucleotide binding site [chemical binding]; other site 758793014881 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793014882 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793014883 Walker A/P-loop; other site 758793014884 ATP binding site [chemical binding]; other site 758793014885 Q-loop/lid; other site 758793014886 ABC transporter signature motif; other site 758793014887 Walker B; other site 758793014888 D-loop; other site 758793014889 H-loop/switch region; other site 758793014890 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793014891 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793014892 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793014893 TM-ABC transporter signature motif; other site 758793014894 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 758793014895 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793014896 putative ligand binding site [chemical binding]; other site 758793014897 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 758793014898 metal coordination site [ion binding]; other site 758793014899 NifQ; Region: NifQ; pfam04891 758793014900 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 758793014901 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 758793014902 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793014903 E3 interaction surface; other site 758793014904 lipoyl attachment site [posttranslational modification]; other site 758793014905 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 758793014906 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 758793014907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793014908 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793014909 CHASE3 domain; Region: CHASE3; pfam05227 758793014910 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793014911 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 758793014912 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 758793014913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793014914 dimer interface [polypeptide binding]; other site 758793014915 phosphorylation site [posttranslational modification] 758793014916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793014917 ATP binding site [chemical binding]; other site 758793014918 Mg2+ binding site [ion binding]; other site 758793014919 G-X-G motif; other site 758793014920 Response regulator receiver domain; Region: Response_reg; pfam00072 758793014921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793014922 active site 758793014923 phosphorylation site [posttranslational modification] 758793014924 intermolecular recognition site; other site 758793014925 dimerization interface [polypeptide binding]; other site 758793014926 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793014927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793014928 active site 758793014929 phosphorylation site [posttranslational modification] 758793014930 intermolecular recognition site; other site 758793014931 Response regulator receiver domain; Region: Response_reg; pfam00072 758793014932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793014933 active site 758793014934 phosphorylation site [posttranslational modification] 758793014935 intermolecular recognition site; other site 758793014936 dimerization interface [polypeptide binding]; other site 758793014937 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 758793014938 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 758793014939 NAD(P) binding site [chemical binding]; other site 758793014940 homotetramer interface [polypeptide binding]; other site 758793014941 homodimer interface [polypeptide binding]; other site 758793014942 active site 758793014943 putative acyltransferase; Provisional; Region: PRK05790 758793014944 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793014945 dimer interface [polypeptide binding]; other site 758793014946 active site 758793014947 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 758793014948 Cytochrome P450; Region: p450; cl12078 758793014949 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793014950 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 758793014951 FMN-binding pocket [chemical binding]; other site 758793014952 flavin binding motif; other site 758793014953 phosphate binding motif [ion binding]; other site 758793014954 beta-alpha-beta structure motif; other site 758793014955 NAD binding pocket [chemical binding]; other site 758793014956 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793014957 catalytic loop [active] 758793014958 iron binding site [ion binding]; other site 758793014959 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 758793014960 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 758793014961 manganese transport protein MntH; Reviewed; Region: PRK00701 758793014962 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 758793014963 Phage integrase protein; Region: DUF3701; pfam12482 758793014964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758793014965 active site 758793014966 DNA binding site [nucleotide binding] 758793014967 Int/Topo IB signature motif; other site 758793014968 ParA-like protein; Provisional; Region: PHA02518 758793014969 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793014970 P-loop; other site 758793014971 Magnesium ion binding site [ion binding]; other site 758793014972 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 758793014973 ParB-like nuclease domain; Region: ParB; smart00470 758793014974 Initiator Replication protein; Region: Rep_3; pfam01051 758793014975 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 758793014976 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 758793014977 active site 758793014978 catalytic residues [active] 758793014979 Int/Topo IB signature motif; other site 758793014980 DNA binding site [nucleotide binding] 758793014981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 758793014982 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 758793014983 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 758793014984 CsbD-like; Region: CsbD; pfam05532 758793014985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758793014986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758793014987 non-specific DNA binding site [nucleotide binding]; other site 758793014988 salt bridge; other site 758793014989 sequence-specific DNA binding site [nucleotide binding]; other site 758793014990 Cupin domain; Region: Cupin_2; pfam07883 758793014991 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 758793014992 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 758793014993 substrate-cofactor binding pocket; other site 758793014994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793014995 catalytic residue [active] 758793014996 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 758793014997 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 758793014998 NAD(P) binding site [chemical binding]; other site 758793014999 YceI-like domain; Region: YceI; smart00867 758793015000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793015001 DNA-binding site [nucleotide binding]; DNA binding site 758793015002 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793015003 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793015004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793015005 homodimer interface [polypeptide binding]; other site 758793015006 catalytic residue [active] 758793015007 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 758793015008 homodimer interface [polypeptide binding]; other site 758793015009 catalytic residues [active] 758793015010 NAD binding site [chemical binding]; other site 758793015011 substrate binding pocket [chemical binding]; other site 758793015012 flexible flap; other site 758793015013 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 758793015014 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 758793015015 active site 758793015016 catalytic residues [active] 758793015017 metal binding site [ion binding]; metal-binding site 758793015018 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 758793015019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793015021 dimerization interface [polypeptide binding]; other site 758793015022 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 758793015023 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 758793015024 metal binding site [ion binding]; metal-binding site 758793015025 putative dimer interface [polypeptide binding]; other site 758793015026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015027 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793015028 putative substrate translocation pore; other site 758793015029 dihydroxy-acid dehydratase; Validated; Region: PRK06131 758793015030 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 758793015031 inhibitor site; inhibition site 758793015032 active site 758793015033 dimer interface [polypeptide binding]; other site 758793015034 catalytic residue [active] 758793015035 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793015036 MarR family; Region: MarR_2; pfam12802 758793015037 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 758793015038 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 758793015039 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 758793015040 putative active site [active] 758793015041 YdjC motif; other site 758793015042 Mg binding site [ion binding]; other site 758793015043 putative homodimer interface [polypeptide binding]; other site 758793015044 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 758793015045 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 758793015046 B12 binding site [chemical binding]; other site 758793015047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793015048 FeS/SAM binding site; other site 758793015049 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 758793015050 ligand binding site; other site 758793015051 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 758793015052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793015053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015054 active site 758793015055 phosphorylation site [posttranslational modification] 758793015056 intermolecular recognition site; other site 758793015057 dimerization interface [polypeptide binding]; other site 758793015058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793015059 DNA binding site [nucleotide binding] 758793015060 sensor protein QseC; Provisional; Region: PRK10337 758793015061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793015062 dimer interface [polypeptide binding]; other site 758793015063 phosphorylation site [posttranslational modification] 758793015064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015065 ATP binding site [chemical binding]; other site 758793015066 Mg2+ binding site [ion binding]; other site 758793015067 G-X-G motif; other site 758793015068 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793015069 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793015070 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793015071 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793015072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793015073 Coenzyme A binding pocket [chemical binding]; other site 758793015074 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 758793015075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793015076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015077 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793015078 putative effector binding pocket; other site 758793015079 dimerization interface [polypeptide binding]; other site 758793015080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793015081 short chain dehydrogenase; Provisional; Region: PRK06197 758793015082 NAD(P) binding site [chemical binding]; other site 758793015083 active site 758793015084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015085 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793015086 putative substrate translocation pore; other site 758793015087 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 758793015088 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793015089 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793015090 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 758793015091 nucleoside/Zn binding site; other site 758793015092 dimer interface [polypeptide binding]; other site 758793015093 catalytic motif [active] 758793015094 LTXXQ motif family protein; Region: LTXXQ; pfam07813 758793015095 dimer interface [polypeptide binding]; other site 758793015096 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 758793015097 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 758793015098 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 758793015099 Ligand Binding Site [chemical binding]; other site 758793015100 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 758793015101 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 758793015102 putative active site [active] 758793015103 putative metal binding site [ion binding]; other site 758793015104 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 758793015105 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 758793015106 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 758793015107 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793015108 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793015109 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793015110 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793015111 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 758793015112 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 758793015113 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 758793015114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793015115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015116 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 758793015117 putative effector binding pocket; other site 758793015118 putative dimerization interface [polypeptide binding]; other site 758793015119 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 758793015120 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 758793015121 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793015122 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 758793015123 FAD binding pocket [chemical binding]; other site 758793015124 FAD binding motif [chemical binding]; other site 758793015125 phosphate binding motif [ion binding]; other site 758793015126 beta-alpha-beta structure motif; other site 758793015127 NAD binding pocket [chemical binding]; other site 758793015128 Heme binding pocket [chemical binding]; other site 758793015129 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 758793015130 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793015131 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 758793015132 putative C-terminal domain interface [polypeptide binding]; other site 758793015133 putative GSH binding site (G-site) [chemical binding]; other site 758793015134 putative dimer interface [polypeptide binding]; other site 758793015135 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 758793015136 putative N-terminal domain interface [polypeptide binding]; other site 758793015137 putative dimer interface [polypeptide binding]; other site 758793015138 putative substrate binding pocket (H-site) [chemical binding]; other site 758793015139 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 758793015140 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 758793015141 Domain of unknown function DUF20; Region: UPF0118; pfam01594 758793015142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793015143 PAS domain; Region: PAS_9; pfam13426 758793015144 putative active site [active] 758793015145 heme pocket [chemical binding]; other site 758793015146 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 758793015147 dimerization interface [polypeptide binding]; other site 758793015148 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 758793015149 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 758793015150 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793015151 dimer interface [polypeptide binding]; other site 758793015152 putative CheW interface [polypeptide binding]; other site 758793015153 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 758793015154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793015155 NAD(P) binding site [chemical binding]; other site 758793015156 active site 758793015157 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 758793015158 PAS fold; Region: PAS_4; pfam08448 758793015159 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 758793015160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793015161 Walker B motif; other site 758793015162 arginine finger; other site 758793015163 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793015164 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 758793015165 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 758793015166 Predicted permeases [General function prediction only]; Region: COG0679 758793015167 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793015168 Predicted flavoprotein [General function prediction only]; Region: COG0431 758793015169 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 758793015170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793015171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015172 ATP binding site [chemical binding]; other site 758793015173 Mg2+ binding site [ion binding]; other site 758793015174 G-X-G motif; other site 758793015175 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793015176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015177 active site 758793015178 phosphorylation site [posttranslational modification] 758793015179 intermolecular recognition site; other site 758793015180 dimerization interface [polypeptide binding]; other site 758793015181 Response regulator receiver domain; Region: Response_reg; pfam00072 758793015182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015183 active site 758793015184 phosphorylation site [posttranslational modification] 758793015185 intermolecular recognition site; other site 758793015186 dimerization interface [polypeptide binding]; other site 758793015187 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 758793015188 CheC-like family; Region: CheC; pfam04509 758793015189 PAS fold; Region: PAS; pfam00989 758793015190 PAS domain; Region: PAS; smart00091 758793015191 putative active site [active] 758793015192 heme pocket [chemical binding]; other site 758793015193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793015194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793015195 metal binding site [ion binding]; metal-binding site 758793015196 active site 758793015197 I-site; other site 758793015198 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 758793015199 active site lid residues [active] 758793015200 catalytic residues [active] 758793015201 substrate binding pocket [chemical binding]; other site 758793015202 substrate-Mg2+ binding site; other site 758793015203 aspartate-rich region 1; other site 758793015204 aspartate-rich region 2; other site 758793015205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793015206 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 758793015207 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 758793015208 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 758793015209 Active site cavity [active] 758793015210 catalytic acid [active] 758793015211 hypothetical protein; Provisional; Region: PRK07077 758793015212 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 758793015213 VacJ like lipoprotein; Region: VacJ; cl01073 758793015214 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 758793015215 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 758793015216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793015217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015218 active site 758793015219 phosphorylation site [posttranslational modification] 758793015220 intermolecular recognition site; other site 758793015221 dimerization interface [polypeptide binding]; other site 758793015222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793015223 DNA binding residues [nucleotide binding] 758793015224 dimerization interface [polypeptide binding]; other site 758793015225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 758793015226 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 758793015227 Histidine kinase; Region: HisKA_3; pfam07730 758793015228 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 758793015229 ATP binding site [chemical binding]; other site 758793015230 Mg2+ binding site [ion binding]; other site 758793015231 G-X-G motif; other site 758793015232 carbon starvation protein A; Provisional; Region: PRK15015 758793015233 Carbon starvation protein CstA; Region: CstA; pfam02554 758793015234 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 758793015235 Protein of unknown function (DUF466); Region: DUF466; pfam04328 758793015236 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 758793015237 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 758793015238 putative active site [active] 758793015239 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 758793015240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793015241 FeS/SAM binding site; other site 758793015242 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 758793015243 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 758793015244 LytB protein; Region: LYTB; pfam02401 758793015245 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 758793015246 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 758793015247 DXD motif; other site 758793015248 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 758793015249 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 758793015250 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 758793015251 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 758793015252 putative NADP binding site [chemical binding]; other site 758793015253 putative substrate binding site [chemical binding]; other site 758793015254 active site 758793015255 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793015256 GAF domain; Region: GAF_3; pfam13492 758793015257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793015258 dimer interface [polypeptide binding]; other site 758793015259 phosphorylation site [posttranslational modification] 758793015260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015261 ATP binding site [chemical binding]; other site 758793015262 Mg2+ binding site [ion binding]; other site 758793015263 G-X-G motif; other site 758793015264 Response regulator receiver domain; Region: Response_reg; pfam00072 758793015265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015266 active site 758793015267 phosphorylation site [posttranslational modification] 758793015268 intermolecular recognition site; other site 758793015269 dimerization interface [polypeptide binding]; other site 758793015270 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793015271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015272 active site 758793015273 phosphorylation site [posttranslational modification] 758793015274 intermolecular recognition site; other site 758793015275 dimerization interface [polypeptide binding]; other site 758793015276 Response regulator receiver domain; Region: Response_reg; pfam00072 758793015277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015278 active site 758793015279 phosphorylation site [posttranslational modification] 758793015280 intermolecular recognition site; other site 758793015281 dimerization interface [polypeptide binding]; other site 758793015282 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 758793015283 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 758793015284 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 758793015285 CheB methylesterase; Region: CheB_methylest; pfam01339 758793015286 Response regulator receiver domain; Region: Response_reg; pfam00072 758793015287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015288 active site 758793015289 phosphorylation site [posttranslational modification] 758793015290 intermolecular recognition site; other site 758793015291 dimerization interface [polypeptide binding]; other site 758793015292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793015293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793015294 dimer interface [polypeptide binding]; other site 758793015295 phosphorylation site [posttranslational modification] 758793015296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015297 ATP binding site [chemical binding]; other site 758793015298 Mg2+ binding site [ion binding]; other site 758793015299 G-X-G motif; other site 758793015300 acylphosphatase; Provisional; Region: PRK14424 758793015301 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 758793015302 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 758793015303 Predicted permeases [General function prediction only]; Region: RarD; COG2962 758793015304 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 758793015305 Protein of unknown function (DUF962); Region: DUF962; cl01879 758793015306 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 758793015307 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 758793015308 N-acetyl-D-glucosamine binding site [chemical binding]; other site 758793015309 catalytic residue [active] 758793015310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015311 putative transporter; Provisional; Region: PRK10504 758793015312 putative substrate translocation pore; other site 758793015313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758793015314 Zn2+ binding site [ion binding]; other site 758793015315 Mg2+ binding site [ion binding]; other site 758793015316 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 758793015317 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 758793015318 HSP70 interaction site [polypeptide binding]; other site 758793015319 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 758793015320 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793015321 active site 758793015322 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 758793015323 Sulfate transporter family; Region: Sulfate_transp; pfam00916 758793015324 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 758793015325 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793015326 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793015327 ligand binding site [chemical binding]; other site 758793015328 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 758793015329 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 758793015330 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 758793015331 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 758793015332 structural tetrad; other site 758793015333 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 758793015334 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793015335 N-terminal plug; other site 758793015336 ligand-binding site [chemical binding]; other site 758793015337 Histidine kinase; Region: HisKA_3; pfam07730 758793015338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015339 ATP binding site [chemical binding]; other site 758793015340 Mg2+ binding site [ion binding]; other site 758793015341 G-X-G motif; other site 758793015342 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 758793015343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793015344 FeS/SAM binding site; other site 758793015345 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 758793015346 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 758793015347 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 758793015348 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 758793015349 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 758793015350 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 758793015351 FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980 758793015352 putative subunit interface; other site 758793015353 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 758793015354 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 758793015355 FTR, proximal lobe; Region: FTR_C; pfam02741 758793015356 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 758793015357 Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304 758793015358 active site 758793015359 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 758793015360 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 758793015361 molybdopterin cofactor binding site; other site 758793015362 hisA/hisF family protein; Region: hisAF_rel; TIGR00734 758793015363 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 758793015364 active site 758793015365 Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821 758793015366 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793015367 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 758793015368 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 758793015369 nucleotide binding site [chemical binding]; other site 758793015370 substrate binding site [chemical binding]; other site 758793015371 hypothetical protein; Provisional; Region: PRK02227 758793015372 Protein of unknown function (DUF447); Region: DUF447; pfam04289 758793015373 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 758793015374 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 758793015375 homodimer interface [polypeptide binding]; other site 758793015376 active site 758793015377 heterodimer interface [polypeptide binding]; other site 758793015378 catalytic residue [active] 758793015379 metal binding site [ion binding]; metal-binding site 758793015380 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 758793015381 multimerization interface [polypeptide binding]; other site 758793015382 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 758793015383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793015384 Walker A motif; other site 758793015385 ATP binding site [chemical binding]; other site 758793015386 Walker B motif; other site 758793015387 arginine finger; other site 758793015388 fructose-1,6-bisphosphatase family protein; Region: PLN02628 758793015389 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 758793015390 AMP binding site [chemical binding]; other site 758793015391 metal binding site [ion binding]; metal-binding site 758793015392 active site 758793015393 phosphoribulokinase; Provisional; Region: PRK15453 758793015394 transketolase; Reviewed; Region: PRK12753 758793015395 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 758793015396 TPP-binding site [chemical binding]; other site 758793015397 dimer interface [polypeptide binding]; other site 758793015398 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758793015399 PYR/PP interface [polypeptide binding]; other site 758793015400 dimer interface [polypeptide binding]; other site 758793015401 TPP binding site [chemical binding]; other site 758793015402 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793015403 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 758793015404 intersubunit interface [polypeptide binding]; other site 758793015405 active site 758793015406 zinc binding site [ion binding]; other site 758793015407 Na+ binding site [ion binding]; other site 758793015408 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 758793015409 putative active site [active] 758793015410 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 758793015411 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 758793015412 putative catalytic residue [active] 758793015413 dihydropteroate synthase-related protein; Region: TIGR00284 758793015414 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 758793015415 substrate binding pocket [chemical binding]; other site 758793015416 dimer interface [polypeptide binding]; other site 758793015417 inhibitor binding site; inhibition site 758793015418 Archaeal flavoproteins [Energy production and conversion]; Region: COG1036 758793015419 Flavoprotein; Region: Flavoprotein; pfam02441 758793015420 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 758793015421 GAF domain; Region: GAF; pfam01590 758793015422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793015423 Walker A motif; other site 758793015424 ATP binding site [chemical binding]; other site 758793015425 Walker B motif; other site 758793015426 arginine finger; other site 758793015427 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 758793015428 Dihydroneopterin aldolase; Region: FolB; smart00905 758793015429 active site 758793015430 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 758793015431 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 758793015432 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 758793015433 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793015434 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 758793015435 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545 758793015436 trimer interface I [polypeptide binding]; other site 758793015437 putative substrate binding pocket [chemical binding]; other site 758793015438 trimer interface II [polypeptide binding]; other site 758793015439 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 758793015440 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793015441 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 758793015442 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 758793015443 beta-RFAP synthase; Region: beta_RFAP_syn; TIGR00144 758793015444 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 758793015445 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 758793015446 aromatic arch; other site 758793015447 DCoH dimer interaction site [polypeptide binding]; other site 758793015448 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 758793015449 DCoH tetramer interaction site [polypeptide binding]; other site 758793015450 substrate binding site [chemical binding]; other site 758793015451 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 758793015452 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 758793015453 Trp docking motif [polypeptide binding]; other site 758793015454 dimer interface [polypeptide binding]; other site 758793015455 active site 758793015456 small subunit binding site [polypeptide binding]; other site 758793015457 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 758793015458 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 758793015459 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793015460 substrate binding pocket [chemical binding]; other site 758793015461 membrane-bound complex binding site; other site 758793015462 hinge residues; other site 758793015463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793015464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015465 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 758793015466 putative dimerization interface [polypeptide binding]; other site 758793015467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793015468 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 758793015469 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 758793015470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793015471 EthD domain; Region: EthD; cl17553 758793015472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793015473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793015474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015475 putative substrate translocation pore; other site 758793015476 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 758793015477 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 758793015478 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 758793015479 Vi polysaccharide biosynthesis protein TviD; Provisional; Region: PRK15180 758793015480 Vi polysaccharide biosynthesis protein TviE; Provisional; Region: PRK15179 758793015481 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793015482 Vi polysaccharide export protein VexA; Provisional; Region: PRK15175 758793015483 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 758793015484 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758793015485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793015486 Q-loop/lid; other site 758793015487 ABC transporter signature motif; other site 758793015488 Walker B; other site 758793015489 D-loop; other site 758793015490 H-loop/switch region; other site 758793015491 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 758793015492 Vi polysaccharide export protein VexE; Provisional; Region: PRK15174 758793015493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793015494 binding surface 758793015495 TPR motif; other site 758793015496 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 758793015497 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 758793015498 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 758793015499 NAD binding site [chemical binding]; other site 758793015500 substrate binding site [chemical binding]; other site 758793015501 homodimer interface [polypeptide binding]; other site 758793015502 active site 758793015503 Amb_all domain; Region: Amb_all; smart00656 758793015504 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 758793015505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793015506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793015507 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793015508 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 758793015509 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 758793015510 Walker A/P-loop; other site 758793015511 ATP binding site [chemical binding]; other site 758793015512 Q-loop/lid; other site 758793015513 ABC transporter signature motif; other site 758793015514 Walker B; other site 758793015515 D-loop; other site 758793015516 H-loop/switch region; other site 758793015517 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 758793015518 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 758793015519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793015520 dimer interface [polypeptide binding]; other site 758793015521 conserved gate region; other site 758793015522 ABC-ATPase subunit interface; other site 758793015523 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758793015524 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758793015525 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758793015526 putative active site [active] 758793015527 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 758793015528 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 758793015529 AAA domain; Region: AAA_18; pfam13238 758793015530 active site 758793015531 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 758793015532 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 758793015533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793015534 DNA-binding site [nucleotide binding]; DNA binding site 758793015535 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 758793015536 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 758793015537 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 758793015538 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 758793015539 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 758793015540 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 758793015541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793015542 Walker A/P-loop; other site 758793015543 ATP binding site [chemical binding]; other site 758793015544 Q-loop/lid; other site 758793015545 ABC transporter signature motif; other site 758793015546 Walker B; other site 758793015547 D-loop; other site 758793015548 H-loop/switch region; other site 758793015549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793015550 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 758793015551 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793015552 Walker A/P-loop; other site 758793015553 ATP binding site [chemical binding]; other site 758793015554 Q-loop/lid; other site 758793015555 ABC transporter signature motif; other site 758793015556 Walker B; other site 758793015557 D-loop; other site 758793015558 H-loop/switch region; other site 758793015559 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 758793015560 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758793015561 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 758793015562 active site 758793015563 benzoate transport; Region: 2A0115; TIGR00895 758793015564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015565 putative substrate translocation pore; other site 758793015566 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 758793015567 HAMP domain; Region: HAMP; pfam00672 758793015568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793015569 dimer interface [polypeptide binding]; other site 758793015570 putative CheW interface [polypeptide binding]; other site 758793015571 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 758793015572 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 758793015573 Beta-lactamase; Region: Beta-lactamase; pfam00144 758793015574 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 758793015575 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 758793015576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793015577 putative metal binding site [ion binding]; other site 758793015578 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793015579 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015580 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 758793015581 putative dimerization interface [polypeptide binding]; other site 758793015582 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 758793015583 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 758793015584 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 758793015585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793015586 PAS domain; Region: PAS_9; pfam13426 758793015587 putative active site [active] 758793015588 heme pocket [chemical binding]; other site 758793015589 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 758793015590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793015591 putative active site [active] 758793015592 heme pocket [chemical binding]; other site 758793015593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793015594 dimer interface [polypeptide binding]; other site 758793015595 phosphorylation site [posttranslational modification] 758793015596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015597 ATP binding site [chemical binding]; other site 758793015598 Mg2+ binding site [ion binding]; other site 758793015599 G-X-G motif; other site 758793015600 Response regulator receiver domain; Region: Response_reg; pfam00072 758793015601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015602 active site 758793015603 phosphorylation site [posttranslational modification] 758793015604 intermolecular recognition site; other site 758793015605 dimerization interface [polypeptide binding]; other site 758793015606 PhoD-like phosphatase; Region: PhoD; pfam09423 758793015607 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 758793015608 putative active site [active] 758793015609 putative metal binding site [ion binding]; other site 758793015610 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 758793015611 Predicted ATPase [General function prediction only]; Region: COG3910 758793015612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793015613 Walker A/P-loop; other site 758793015614 ATP binding site [chemical binding]; other site 758793015615 Q-loop/lid; other site 758793015616 ABC transporter signature motif; other site 758793015617 Walker B; other site 758793015618 D-loop; other site 758793015619 H-loop/switch region; other site 758793015620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793015623 HAMP domain; Region: HAMP; pfam00672 758793015624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793015625 dimer interface [polypeptide binding]; other site 758793015626 phosphorylation site [posttranslational modification] 758793015627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015628 ATP binding site [chemical binding]; other site 758793015629 Mg2+ binding site [ion binding]; other site 758793015630 G-X-G motif; other site 758793015631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793015632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015633 active site 758793015634 phosphorylation site [posttranslational modification] 758793015635 intermolecular recognition site; other site 758793015636 dimerization interface [polypeptide binding]; other site 758793015637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793015638 DNA binding site [nucleotide binding] 758793015639 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 758793015640 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 758793015641 active site 758793015642 DNA polymerase IV; Validated; Region: PRK02406 758793015643 DNA binding site [nucleotide binding] 758793015644 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 758793015645 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 758793015646 active site 758793015647 iron coordination sites [ion binding]; other site 758793015648 substrate binding pocket [chemical binding]; other site 758793015649 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793015650 NMT1-like family; Region: NMT1_2; pfam13379 758793015651 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793015652 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793015653 Walker A/P-loop; other site 758793015654 ATP binding site [chemical binding]; other site 758793015655 Q-loop/lid; other site 758793015656 ABC transporter signature motif; other site 758793015657 Walker B; other site 758793015658 D-loop; other site 758793015659 H-loop/switch region; other site 758793015660 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793015661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793015662 putative PBP binding loops; other site 758793015663 dimer interface [polypeptide binding]; other site 758793015664 ABC-ATPase subunit interface; other site 758793015665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793015666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015667 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 758793015668 putative effector binding pocket; other site 758793015669 putative dimerization interface [polypeptide binding]; other site 758793015670 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793015671 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793015672 active site 758793015673 catalytic tetrad [active] 758793015674 drug efflux system protein MdtG; Provisional; Region: PRK09874 758793015675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015676 putative substrate translocation pore; other site 758793015677 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 758793015678 putative catalytic site [active] 758793015679 putative phosphate binding site [ion binding]; other site 758793015680 active site 758793015681 metal binding site A [ion binding]; metal-binding site 758793015682 DNA binding site [nucleotide binding] 758793015683 putative AP binding site [nucleotide binding]; other site 758793015684 putative metal binding site B [ion binding]; other site 758793015685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793015686 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 758793015687 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 758793015688 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 758793015689 PhnA protein; Region: PhnA; pfam03831 758793015690 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793015691 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 758793015692 NAD(P) binding site [chemical binding]; other site 758793015693 catalytic residues [active] 758793015694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793015695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015696 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 758793015697 putative dimerization interface [polypeptide binding]; other site 758793015698 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 758793015699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015700 putative substrate translocation pore; other site 758793015701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015702 transcriptional regulator, ArgP family; Region: argP; TIGR03298 758793015703 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 758793015704 putative dimerization interface [polypeptide binding]; other site 758793015705 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 758793015706 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 758793015707 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 758793015708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793015709 DNA-binding site [nucleotide binding]; DNA binding site 758793015710 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 758793015711 FCD domain; Region: FCD; pfam07729 758793015712 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 758793015713 CoA binding domain; Region: CoA_binding; pfam02629 758793015714 CoA-ligase; Region: Ligase_CoA; pfam00549 758793015715 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 758793015716 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 758793015717 CoA-ligase; Region: Ligase_CoA; pfam00549 758793015718 formyl-coenzyme A transferase; Provisional; Region: PRK05398 758793015719 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793015720 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 758793015721 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 758793015722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793015723 CsbD-like; Region: CsbD; pfam05532 758793015724 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 758793015725 Response regulator receiver domain; Region: Response_reg; pfam00072 758793015726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015727 active site 758793015728 phosphorylation site [posttranslational modification] 758793015729 intermolecular recognition site; other site 758793015730 dimerization interface [polypeptide binding]; other site 758793015731 circadian clock protein KaiC; Reviewed; Region: PRK09302 758793015732 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793015733 Walker A motif; other site 758793015734 ATP binding site [chemical binding]; other site 758793015735 Walker B motif; other site 758793015736 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 758793015737 Walker A motif; other site 758793015738 ATP binding site [chemical binding]; other site 758793015739 Walker B motif; other site 758793015740 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 758793015741 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 758793015742 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 758793015743 DNA binding site [nucleotide binding] 758793015744 active site 758793015745 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 758793015746 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 758793015747 active site 758793015748 substrate binding site [chemical binding]; other site 758793015749 Mg2+ binding site [ion binding]; other site 758793015750 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793015751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793015752 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 758793015753 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 758793015754 hypothetical protein; Provisional; Region: PRK02237 758793015755 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 758793015756 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 758793015757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015758 putative substrate translocation pore; other site 758793015759 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 758793015760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793015761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793015762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793015763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793015764 active site 758793015765 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 758793015766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793015767 acyl-activating enzyme (AAE) consensus motif; other site 758793015768 AMP binding site [chemical binding]; other site 758793015769 active site 758793015770 CoA binding site [chemical binding]; other site 758793015771 enoyl-CoA hydratase; Provisional; Region: PRK09076 758793015772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793015773 substrate binding site [chemical binding]; other site 758793015774 oxyanion hole (OAH) forming residues; other site 758793015775 trimer interface [polypeptide binding]; other site 758793015776 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 758793015777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 758793015778 substrate binding site [chemical binding]; other site 758793015779 oxyanion hole (OAH) forming residues; other site 758793015780 trimer interface [polypeptide binding]; other site 758793015781 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 758793015782 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 758793015783 Domain of unknown function DUF20; Region: UPF0118; pfam01594 758793015784 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 758793015785 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 758793015786 Trp docking motif [polypeptide binding]; other site 758793015787 active site 758793015788 Cytochrome c553 [Energy production and conversion]; Region: COG2863 758793015789 Cytochrome c; Region: Cytochrom_C; cl11414 758793015790 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 758793015791 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 758793015792 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 758793015793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 758793015794 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 758793015795 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 758793015796 dimer interface [polypeptide binding]; other site 758793015797 RNA polymerase sigma factor; Reviewed; Region: PRK05602 758793015798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793015799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793015800 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 758793015801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793015802 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793015803 dimerization interface [polypeptide binding]; other site 758793015804 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793015805 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 758793015806 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 758793015807 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793015808 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793015809 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 758793015810 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758793015811 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758793015812 Walker A/P-loop; other site 758793015813 ATP binding site [chemical binding]; other site 758793015814 Q-loop/lid; other site 758793015815 ABC transporter signature motif; other site 758793015816 Walker B; other site 758793015817 D-loop; other site 758793015818 H-loop/switch region; other site 758793015819 ABC-2 type transporter; Region: ABC2_membrane; cl17235 758793015820 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758793015821 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 758793015822 SelR domain; Region: SelR; pfam01641 758793015823 Isochorismatase family; Region: Isochorismatase; pfam00857 758793015824 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 758793015825 catalytic triad [active] 758793015826 conserved cis-peptide bond; other site 758793015827 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 758793015828 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 758793015829 active site 758793015830 nucleophile elbow; other site 758793015831 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 758793015832 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758793015833 putative active site [active] 758793015834 putative metal binding site [ion binding]; other site 758793015835 succinic semialdehyde dehydrogenase; Region: PLN02278 758793015836 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 758793015837 tetramerization interface [polypeptide binding]; other site 758793015838 NAD(P) binding site [chemical binding]; other site 758793015839 catalytic residues [active] 758793015840 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 758793015841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793015842 inhibitor-cofactor binding pocket; inhibition site 758793015843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793015844 catalytic residue [active] 758793015845 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793015846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793015847 DNA-binding site [nucleotide binding]; DNA binding site 758793015848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793015849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793015850 homodimer interface [polypeptide binding]; other site 758793015851 catalytic residue [active] 758793015852 Protein of unknown function (DUF3233); Region: DUF3233; pfam11557 758793015853 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 758793015854 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 758793015855 metal binding site [ion binding]; metal-binding site 758793015856 putative dimer interface [polypeptide binding]; other site 758793015857 Cache domain; Region: Cache_2; pfam08269 758793015858 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 758793015859 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793015860 dimer interface [polypeptide binding]; other site 758793015861 putative CheW interface [polypeptide binding]; other site 758793015862 adhesin; Provisional; Region: PRK09752 758793015863 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793015864 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 758793015865 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 758793015866 Fe-S cluster binding site [ion binding]; other site 758793015867 active site 758793015868 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 758793015869 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 758793015870 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 758793015871 Ligand binding site; other site 758793015872 metal-binding site 758793015873 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 758793015874 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 758793015875 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 758793015876 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 758793015877 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 758793015878 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 758793015879 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793015880 catalytic loop [active] 758793015881 iron binding site [ion binding]; other site 758793015882 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 758793015883 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793015884 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 758793015885 catalytic triad [active] 758793015886 conserved cis-peptide bond; other site 758793015887 Uncharacterized conserved protein [Function unknown]; Region: COG3791 758793015888 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 758793015889 peptidase domain interface [polypeptide binding]; other site 758793015890 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 758793015891 active site 758793015892 catalytic triad [active] 758793015893 calcium binding site [ion binding]; other site 758793015894 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 758793015895 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 758793015896 hydroperoxidase II; Provisional; Region: katE; PRK11249 758793015897 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 758793015898 tetramer interface [polypeptide binding]; other site 758793015899 heme binding pocket [chemical binding]; other site 758793015900 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 758793015901 domain interactions; other site 758793015902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793015903 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793015904 substrate binding pocket [chemical binding]; other site 758793015905 membrane-bound complex binding site; other site 758793015906 hinge residues; other site 758793015907 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793015908 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793015909 substrate binding pocket [chemical binding]; other site 758793015910 membrane-bound complex binding site; other site 758793015911 hinge residues; other site 758793015912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793015913 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793015914 dimer interface [polypeptide binding]; other site 758793015915 phosphorylation site [posttranslational modification] 758793015916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793015917 ATP binding site [chemical binding]; other site 758793015918 Mg2+ binding site [ion binding]; other site 758793015919 G-X-G motif; other site 758793015920 Response regulator receiver domain; Region: Response_reg; pfam00072 758793015921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793015922 active site 758793015923 phosphorylation site [posttranslational modification] 758793015924 intermolecular recognition site; other site 758793015925 dimerization interface [polypeptide binding]; other site 758793015926 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 758793015927 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 758793015928 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 758793015929 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 758793015930 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 758793015931 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 758793015932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793015933 Walker A/P-loop; other site 758793015934 ATP binding site [chemical binding]; other site 758793015935 Q-loop/lid; other site 758793015936 ABC transporter signature motif; other site 758793015937 Walker B; other site 758793015938 D-loop; other site 758793015939 H-loop/switch region; other site 758793015940 TOBE domain; Region: TOBE_2; pfam08402 758793015941 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 758793015942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793015943 dimer interface [polypeptide binding]; other site 758793015944 conserved gate region; other site 758793015945 putative PBP binding loops; other site 758793015946 ABC-ATPase subunit interface; other site 758793015947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 758793015948 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 758793015949 homodimer interface [polypeptide binding]; other site 758793015950 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 758793015951 active site pocket [active] 758793015952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793015953 dimerization interface [polypeptide binding]; other site 758793015954 putative DNA binding site [nucleotide binding]; other site 758793015955 putative Zn2+ binding site [ion binding]; other site 758793015956 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 758793015957 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 758793015958 FMN binding site [chemical binding]; other site 758793015959 active site 758793015960 substrate binding site [chemical binding]; other site 758793015961 catalytic residue [active] 758793015962 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 758793015963 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 758793015964 TrkA-C domain; Region: TrkA_C; pfam02080 758793015965 TrkA-C domain; Region: TrkA_C; pfam02080 758793015966 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 758793015967 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 758793015968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793015969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793015970 homodimer interface [polypeptide binding]; other site 758793015971 catalytic residue [active] 758793015972 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793015973 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793015974 trimer interface [polypeptide binding]; other site 758793015975 eyelet of channel; other site 758793015976 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 758793015977 active site 758793015978 Zn binding site [ion binding]; other site 758793015979 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793015980 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793015981 substrate binding pocket [chemical binding]; other site 758793015982 membrane-bound complex binding site; other site 758793015983 hinge residues; other site 758793015984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793015985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015986 putative substrate translocation pore; other site 758793015987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793015988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793015989 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 758793015990 benzoate transport; Region: 2A0115; TIGR00895 758793015991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015992 putative substrate translocation pore; other site 758793015993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793015994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793015995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793015996 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 758793015997 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 758793015998 isovaleryl-CoA dehydrogenase; Region: PLN02519 758793015999 substrate binding site [chemical binding]; other site 758793016000 FAD binding site [chemical binding]; other site 758793016001 catalytic base [active] 758793016002 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 758793016003 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 758793016004 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 758793016005 ATP-grasp domain; Region: ATP-grasp_4; cl17255 758793016006 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 758793016007 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 758793016008 carboxyltransferase (CT) interaction site; other site 758793016009 biotinylation site [posttranslational modification]; other site 758793016010 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 758793016011 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793016012 ligand binding site [chemical binding]; other site 758793016013 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 758793016014 Domain of unknown function DUF20; Region: UPF0118; pfam01594 758793016015 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 758793016016 2-methylcitrate dehydratase; Region: prpD; TIGR02330 758793016017 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 758793016018 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 758793016019 dimer interface [polypeptide binding]; other site 758793016020 active site 758793016021 citrylCoA binding site [chemical binding]; other site 758793016022 oxalacetate/citrate binding site [chemical binding]; other site 758793016023 coenzyme A binding site [chemical binding]; other site 758793016024 catalytic triad [active] 758793016025 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793016026 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 758793016027 tetramer interface [polypeptide binding]; other site 758793016028 active site 758793016029 Mg2+/Mn2+ binding site [ion binding]; other site 758793016030 Propionate catabolism activator; Region: PrpR_N; pfam06506 758793016031 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 758793016032 PAS domain; Region: PAS; smart00091 758793016033 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793016034 Walker A motif; other site 758793016035 ATP binding site [chemical binding]; other site 758793016036 Walker B motif; other site 758793016037 arginine finger; other site 758793016038 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 758793016039 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 758793016040 active site 758793016041 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 758793016042 heterodimer interface [polypeptide binding]; other site 758793016043 multimer interface [polypeptide binding]; other site 758793016044 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 758793016045 active site 758793016046 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 758793016047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793016049 dimerization interface [polypeptide binding]; other site 758793016050 Response regulator receiver domain; Region: Response_reg; pfam00072 758793016051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016052 active site 758793016053 phosphorylation site [posttranslational modification] 758793016054 intermolecular recognition site; other site 758793016055 dimerization interface [polypeptide binding]; other site 758793016056 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 758793016057 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 758793016058 putative acyl-acceptor binding pocket; other site 758793016059 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 758793016060 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793016061 PAS domain; Region: PAS; smart00091 758793016062 PAS domain S-box; Region: sensory_box; TIGR00229 758793016063 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793016064 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793016065 metal binding site [ion binding]; metal-binding site 758793016066 active site 758793016067 I-site; other site 758793016068 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793016069 MarR family; Region: MarR_2; pfam12802 758793016070 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 758793016071 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 758793016072 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793016073 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793016074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793016075 putative DNA binding site [nucleotide binding]; other site 758793016076 putative Zn2+ binding site [ion binding]; other site 758793016077 AsnC family; Region: AsnC_trans_reg; pfam01037 758793016078 urocanate hydratase; Provisional; Region: PRK05414 758793016079 imidazolonepropionase; Validated; Region: PRK09356 758793016080 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 758793016081 active site 758793016082 Predicted membrane protein [Function unknown]; Region: COG2261 758793016083 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 758793016084 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 758793016085 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 758793016086 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793016087 ligand binding site [chemical binding]; other site 758793016088 YciI-like protein; Reviewed; Region: PRK12866 758793016089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793016090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016091 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 758793016092 putative effector binding pocket; other site 758793016093 putative dimerization interface [polypeptide binding]; other site 758793016094 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793016095 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793016096 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 758793016097 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 758793016098 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 758793016099 putative active site [active] 758793016100 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 758793016101 catalytic nucleophile [active] 758793016102 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 758793016103 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793016104 Walker A/P-loop; other site 758793016105 ATP binding site [chemical binding]; other site 758793016106 Q-loop/lid; other site 758793016107 ABC transporter signature motif; other site 758793016108 Walker B; other site 758793016109 D-loop; other site 758793016110 H-loop/switch region; other site 758793016111 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 758793016112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793016113 Walker A/P-loop; other site 758793016114 ATP binding site [chemical binding]; other site 758793016115 Q-loop/lid; other site 758793016116 ABC transporter signature motif; other site 758793016117 Walker B; other site 758793016118 D-loop; other site 758793016119 H-loop/switch region; other site 758793016120 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 758793016121 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 758793016122 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 758793016123 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 758793016124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793016125 dimer interface [polypeptide binding]; other site 758793016126 conserved gate region; other site 758793016127 putative PBP binding loops; other site 758793016128 ABC-ATPase subunit interface; other site 758793016129 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 758793016130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793016131 dimer interface [polypeptide binding]; other site 758793016132 conserved gate region; other site 758793016133 putative PBP binding loops; other site 758793016134 ABC-ATPase subunit interface; other site 758793016135 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 758793016136 homodimer interface [polypeptide binding]; other site 758793016137 homotetramer interface [polypeptide binding]; other site 758793016138 active site pocket [active] 758793016139 cleavage site 758793016140 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 758793016141 SxDxEG motif; other site 758793016142 active site 758793016143 metal binding site [ion binding]; metal-binding site 758793016144 homopentamer interface [polypeptide binding]; other site 758793016145 chromosome condensation membrane protein; Provisional; Region: PRK14196 758793016146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 758793016147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793016148 Coenzyme A binding pocket [chemical binding]; other site 758793016149 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 758793016150 active sites [active] 758793016151 tetramer interface [polypeptide binding]; other site 758793016152 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 758793016153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793016154 DNA-binding site [nucleotide binding]; DNA binding site 758793016155 UTRA domain; Region: UTRA; pfam07702 758793016156 HutD; Region: HutD; pfam05962 758793016157 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 758793016158 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 758793016159 active site 758793016160 N-formylglutamate amidohydrolase; Region: FGase; cl01522 758793016161 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793016162 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 758793016163 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 758793016164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793016165 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 758793016166 allantoate amidohydrolase; Reviewed; Region: PRK09290 758793016167 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 758793016168 active site 758793016169 metal binding site [ion binding]; metal-binding site 758793016170 dimer interface [polypeptide binding]; other site 758793016171 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 758793016172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793016173 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 758793016174 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 758793016175 homodimer interface [polypeptide binding]; other site 758793016176 active site 758793016177 FMN binding site [chemical binding]; other site 758793016178 substrate binding site [chemical binding]; other site 758793016179 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 758793016180 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 758793016181 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 758793016182 Na binding site [ion binding]; other site 758793016183 putative substrate binding site [chemical binding]; other site 758793016184 phenylhydantoinase; Validated; Region: PRK08323 758793016185 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 758793016186 tetramer interface [polypeptide binding]; other site 758793016187 active site 758793016188 CDP-diacylglycerol pyrophosphatase; Region: CDH; pfam02611 758793016189 aspartate carbamoyltransferase; Provisional; Region: PRK11891 758793016190 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 758793016191 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 758793016192 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 758793016193 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 758793016194 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 758793016195 dimer interface [polypeptide binding]; other site 758793016196 active site residues [active] 758793016197 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 758793016198 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 758793016199 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 758793016200 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 758793016201 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 758793016202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793016203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016204 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 758793016205 putative effector binding pocket; other site 758793016206 dimerization interface [polypeptide binding]; other site 758793016207 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 758793016208 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793016209 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793016210 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 758793016211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016212 putative substrate translocation pore; other site 758793016213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016214 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793016215 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 758793016216 CoenzymeA binding site [chemical binding]; other site 758793016217 subunit interaction site [polypeptide binding]; other site 758793016218 PHB binding site; other site 758793016219 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 758793016220 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793016221 inhibitor-cofactor binding pocket; inhibition site 758793016222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793016223 catalytic residue [active] 758793016224 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793016225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793016226 DNA-binding site [nucleotide binding]; DNA binding site 758793016227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793016228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793016229 homodimer interface [polypeptide binding]; other site 758793016230 catalytic residue [active] 758793016231 H-NS histone family; Region: Histone_HNS; pfam00816 758793016232 hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367 758793016233 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 758793016234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 758793016235 FeS/SAM binding site; other site 758793016236 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 758793016237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793016238 S-adenosylmethionine binding site [chemical binding]; other site 758793016239 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 758793016240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793016241 substrate binding pocket [chemical binding]; other site 758793016242 membrane-bound complex binding site; other site 758793016243 hinge residues; other site 758793016244 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 758793016245 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 758793016246 putative dimer interface [polypeptide binding]; other site 758793016247 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 758793016248 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 758793016249 putative dimer interface [polypeptide binding]; other site 758793016250 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 758793016251 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 758793016252 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758793016253 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758793016254 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 758793016255 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 758793016256 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 758793016257 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 758793016258 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 758793016259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793016260 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 758793016261 metal binding site [ion binding]; metal-binding site 758793016262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 758793016263 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 758793016264 active site 758793016265 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793016266 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 758793016267 putative active site [active] 758793016268 Zn binding site [ion binding]; other site 758793016269 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 758793016270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793016271 Coenzyme A binding pocket [chemical binding]; other site 758793016272 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 758793016273 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 758793016274 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 758793016275 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 758793016276 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 758793016277 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 758793016278 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 758793016279 active site 1 [active] 758793016280 dimer interface [polypeptide binding]; other site 758793016281 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 758793016282 hexamer interface [polypeptide binding]; other site 758793016283 active site 2 [active] 758793016284 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 758793016285 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 758793016286 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 758793016287 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 758793016288 Water Stress and Hypersensitive response; Region: WHy; smart00769 758793016289 Cupin domain; Region: Cupin_2; cl17218 758793016290 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 758793016291 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 758793016292 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 758793016293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 758793016294 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 758793016295 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793016296 FAD binding domain; Region: FAD_binding_4; pfam01565 758793016297 Berberine and berberine like; Region: BBE; pfam08031 758793016298 Protein required for attachment to host cells; Region: Host_attach; pfam10116 758793016299 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 758793016300 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 758793016301 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 758793016302 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793016303 N-terminal plug; other site 758793016304 ligand-binding site [chemical binding]; other site 758793016305 transcriptional activator TtdR; Provisional; Region: PRK09801 758793016306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016307 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 758793016308 putative effector binding pocket; other site 758793016309 putative dimerization interface [polypeptide binding]; other site 758793016310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793016311 binding surface 758793016312 TPR motif; other site 758793016313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793016314 TPR motif; other site 758793016315 binding surface 758793016316 Tetratricopeptide repeat; Region: TPR_16; pfam13432 758793016317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793016318 TPR motif; other site 758793016319 binding surface 758793016320 Tetratricopeptide repeat; Region: TPR_12; pfam13424 758793016321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793016322 TPR motif; other site 758793016323 binding surface 758793016324 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 758793016325 endo-1,4-D-glucanase; Provisional; Region: PRK11097 758793016326 cellulose synthase regulator protein; Provisional; Region: PRK11114 758793016327 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 758793016328 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 758793016329 DXD motif; other site 758793016330 PilZ domain; Region: PilZ; pfam07238 758793016331 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 758793016332 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793016333 P-loop; other site 758793016334 Magnesium ion binding site [ion binding]; other site 758793016335 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793016336 Magnesium ion binding site [ion binding]; other site 758793016337 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 758793016338 phospholipase D epsilon; Region: PLN02352 758793016339 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 758793016340 NADH(P)-binding; Region: NAD_binding_10; pfam13460 758793016341 NAD binding site [chemical binding]; other site 758793016342 substrate binding site [chemical binding]; other site 758793016343 putative active site [active] 758793016344 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 758793016345 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793016346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793016347 dimer interface [polypeptide binding]; other site 758793016348 conserved gate region; other site 758793016349 putative PBP binding loops; other site 758793016350 ABC-ATPase subunit interface; other site 758793016351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793016352 dimer interface [polypeptide binding]; other site 758793016353 conserved gate region; other site 758793016354 putative PBP binding loops; other site 758793016355 ABC-ATPase subunit interface; other site 758793016356 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 758793016357 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 758793016358 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793016359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793016360 Walker A/P-loop; other site 758793016361 ATP binding site [chemical binding]; other site 758793016362 Q-loop/lid; other site 758793016363 ABC transporter signature motif; other site 758793016364 Walker B; other site 758793016365 D-loop; other site 758793016366 H-loop/switch region; other site 758793016367 TOBE domain; Region: TOBE_2; pfam08402 758793016368 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793016369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793016370 DNA-binding site [nucleotide binding]; DNA binding site 758793016371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793016372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793016373 homodimer interface [polypeptide binding]; other site 758793016374 catalytic residue [active] 758793016375 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 758793016376 putative chaperone protein EcpD; Provisional; Region: PRK09926 758793016377 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 758793016378 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 758793016379 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 758793016380 PapC N-terminal domain; Region: PapC_N; pfam13954 758793016381 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 758793016382 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793016383 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 758793016384 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 758793016385 putative active site [active] 758793016386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758793016387 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 758793016388 Walker A/P-loop; other site 758793016389 ATP binding site [chemical binding]; other site 758793016390 Q-loop/lid; other site 758793016391 ABC transporter signature motif; other site 758793016392 Walker B; other site 758793016393 D-loop; other site 758793016394 H-loop/switch region; other site 758793016395 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 758793016396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793016397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793016398 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 758793016399 SnoaL-like domain; Region: SnoaL_2; pfam12680 758793016400 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 758793016401 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 758793016402 Cl binding site [ion binding]; other site 758793016403 oligomer interface [polypeptide binding]; other site 758793016404 Response regulator receiver domain; Region: Response_reg; pfam00072 758793016405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016406 active site 758793016407 phosphorylation site [posttranslational modification] 758793016408 intermolecular recognition site; other site 758793016409 dimerization interface [polypeptide binding]; other site 758793016410 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 758793016411 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793016412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016413 active site 758793016414 phosphorylation site [posttranslational modification] 758793016415 intermolecular recognition site; other site 758793016416 dimerization interface [polypeptide binding]; other site 758793016417 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 758793016418 FOG: CBS domain [General function prediction only]; Region: COG0517 758793016419 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 758793016420 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 758793016421 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 758793016422 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758793016423 active site 758793016424 metal binding site [ion binding]; metal-binding site 758793016425 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 758793016426 trimer interface [polypeptide binding]; other site 758793016427 putative Zn binding site [ion binding]; other site 758793016428 MAPEG family; Region: MAPEG; cl09190 758793016429 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 758793016430 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 758793016431 active site 758793016432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 758793016433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793016434 dimer interface [polypeptide binding]; other site 758793016435 phosphorylation site [posttranslational modification] 758793016436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793016437 ATP binding site [chemical binding]; other site 758793016438 Mg2+ binding site [ion binding]; other site 758793016439 G-X-G motif; other site 758793016440 Response regulator receiver domain; Region: Response_reg; pfam00072 758793016441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016442 active site 758793016443 phosphorylation site [posttranslational modification] 758793016444 intermolecular recognition site; other site 758793016445 dimerization interface [polypeptide binding]; other site 758793016446 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 758793016447 nucleotide binding site [chemical binding]; other site 758793016448 putative NEF/HSP70 interaction site [polypeptide binding]; other site 758793016449 SBD interface [polypeptide binding]; other site 758793016450 DNA-K related protein; Region: DUF3731; pfam12531 758793016451 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 758793016452 nucleotide binding site [chemical binding]; other site 758793016453 putative NEF/HSP70 interaction site [polypeptide binding]; other site 758793016454 SBD interface [polypeptide binding]; other site 758793016455 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 758793016456 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 758793016457 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793016458 NMT1-like family; Region: NMT1_2; pfam13379 758793016459 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 758793016460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016461 active site 758793016462 phosphorylation site [posttranslational modification] 758793016463 intermolecular recognition site; other site 758793016464 dimerization interface [polypeptide binding]; other site 758793016465 ANTAR domain; Region: ANTAR; pfam03861 758793016466 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 758793016467 active site 758793016468 SAM binding site [chemical binding]; other site 758793016469 homodimer interface [polypeptide binding]; other site 758793016470 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 758793016471 nitrite reductase subunit NirD; Provisional; Region: PRK14989 758793016472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793016473 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758793016474 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758793016475 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758793016476 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 758793016477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758793016478 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793016479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793016480 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 758793016481 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 758793016482 [4Fe-4S] binding site [ion binding]; other site 758793016483 molybdopterin cofactor binding site; other site 758793016484 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 758793016485 molybdopterin cofactor binding site; other site 758793016486 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 758793016487 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 758793016488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793016489 dimer interface [polypeptide binding]; other site 758793016490 phosphorylation site [posttranslational modification] 758793016491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793016492 ATP binding site [chemical binding]; other site 758793016493 Mg2+ binding site [ion binding]; other site 758793016494 G-X-G motif; other site 758793016495 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 758793016496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016497 active site 758793016498 phosphorylation site [posttranslational modification] 758793016499 intermolecular recognition site; other site 758793016500 dimerization interface [polypeptide binding]; other site 758793016501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793016502 DNA binding site [nucleotide binding] 758793016503 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793016504 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793016505 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793016506 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793016507 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793016508 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793016509 manganese transport protein MntH; Reviewed; Region: PRK00701 758793016510 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 758793016511 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 758793016512 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 758793016513 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 758793016514 ligand binding site [chemical binding]; other site 758793016515 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 758793016516 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 758793016517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758793016518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758793016519 non-specific DNA binding site [nucleotide binding]; other site 758793016520 salt bridge; other site 758793016521 sequence-specific DNA binding site [nucleotide binding]; other site 758793016522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793016524 putative substrate translocation pore; other site 758793016525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793016527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016528 active site 758793016529 phosphorylation site [posttranslational modification] 758793016530 intermolecular recognition site; other site 758793016531 dimerization interface [polypeptide binding]; other site 758793016532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793016533 DNA binding site [nucleotide binding] 758793016534 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 758793016535 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 758793016536 inhibitor site; inhibition site 758793016537 active site 758793016538 dimer interface [polypeptide binding]; other site 758793016539 catalytic residue [active] 758793016540 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 758793016541 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 758793016542 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793016543 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 758793016544 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758793016545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793016546 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 758793016547 PAS fold; Region: PAS_4; pfam08448 758793016548 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793016549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793016550 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793016551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016552 active site 758793016553 phosphorylation site [posttranslational modification] 758793016554 intermolecular recognition site; other site 758793016555 dimerization interface [polypeptide binding]; other site 758793016556 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793016557 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 758793016558 putative C-terminal domain interface [polypeptide binding]; other site 758793016559 putative dimer interface [polypeptide binding]; other site 758793016560 putative GSH binding site (G-site) [chemical binding]; other site 758793016561 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 758793016562 putative N-terminal domain interface [polypeptide binding]; other site 758793016563 putative dimer interface [polypeptide binding]; other site 758793016564 putative substrate binding pocket (H-site) [chemical binding]; other site 758793016565 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 758793016566 Part of AAA domain; Region: AAA_19; pfam13245 758793016567 Family description; Region: UvrD_C_2; pfam13538 758793016568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793016569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793016570 dimer interface [polypeptide binding]; other site 758793016571 phosphorylation site [posttranslational modification] 758793016572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793016573 ATP binding site [chemical binding]; other site 758793016574 Mg2+ binding site [ion binding]; other site 758793016575 G-X-G motif; other site 758793016576 Response regulator receiver domain; Region: Response_reg; pfam00072 758793016577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016578 active site 758793016579 phosphorylation site [posttranslational modification] 758793016580 intermolecular recognition site; other site 758793016581 dimerization interface [polypeptide binding]; other site 758793016582 BetR domain; Region: BetR; pfam08667 758793016583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016584 active site 758793016585 phosphorylation site [posttranslational modification] 758793016586 intermolecular recognition site; other site 758793016587 dimerization interface [polypeptide binding]; other site 758793016588 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793016589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793016590 NAD(P) binding site [chemical binding]; other site 758793016591 active site 758793016592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016593 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793016594 putative substrate translocation pore; other site 758793016595 L-rhamnonate dehydratase; Provisional; Region: PRK15440 758793016596 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 758793016597 putative active site pocket [active] 758793016598 putative metal binding site [ion binding]; other site 758793016599 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793016600 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793016601 NAD(P) binding site [chemical binding]; other site 758793016602 active site 758793016603 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 758793016604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016605 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 758793016606 putative dimerization interface [polypeptide binding]; other site 758793016607 Domain of unknown function (DUF718); Region: DUF718; pfam05336 758793016608 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793016609 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793016610 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793016611 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793016612 Walker A/P-loop; other site 758793016613 ATP binding site [chemical binding]; other site 758793016614 Q-loop/lid; other site 758793016615 ABC transporter signature motif; other site 758793016616 Walker B; other site 758793016617 D-loop; other site 758793016618 H-loop/switch region; other site 758793016619 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793016620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793016621 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793016622 TM-ABC transporter signature motif; other site 758793016623 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793016624 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793016625 TM-ABC transporter signature motif; other site 758793016626 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 758793016627 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 758793016628 ligand binding site [chemical binding]; other site 758793016629 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 758793016630 Homeodomain-like domain; Region: HTH_23; pfam13384 758793016631 Winged helix-turn helix; Region: HTH_29; pfam13551 758793016632 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 758793016633 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 758793016634 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 758793016635 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 758793016636 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 758793016637 Fatty acid desaturase; Region: FA_desaturase; pfam00487 758793016638 putative di-iron ligands [ion binding]; other site 758793016639 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 758793016640 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 758793016641 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 758793016642 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 758793016643 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 758793016644 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 758793016645 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 758793016646 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 758793016647 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 758793016648 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 758793016649 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 758793016650 nucleotide binding site [chemical binding]; other site 758793016651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 758793016652 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 758793016653 active site 758793016654 motif I; other site 758793016655 motif II; other site 758793016656 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 758793016657 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 758793016658 rRNA binding site [nucleotide binding]; other site 758793016659 predicted 30S ribosome binding site; other site 758793016660 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 758793016661 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 758793016662 oligomer interface [polypeptide binding]; other site 758793016663 metal binding site [ion binding]; metal-binding site 758793016664 metal binding site [ion binding]; metal-binding site 758793016665 putative Cl binding site [ion binding]; other site 758793016666 basic sphincter; other site 758793016667 hydrophobic gate; other site 758793016668 periplasmic entrance; other site 758793016669 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 758793016670 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 758793016671 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 758793016672 Peptidase family M23; Region: Peptidase_M23; pfam01551 758793016673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793016674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793016676 dimerization interface [polypeptide binding]; other site 758793016677 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 758793016678 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 758793016679 tetrameric interface [polypeptide binding]; other site 758793016680 NAD binding site [chemical binding]; other site 758793016681 catalytic residues [active] 758793016682 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 758793016683 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793016684 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 758793016685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793016686 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793016687 glucose-1-dehydrogenase; Provisional; Region: PRK08936 758793016688 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 758793016689 NAD binding site [chemical binding]; other site 758793016690 homodimer interface [polypeptide binding]; other site 758793016691 active site 758793016692 glycogen synthase; Provisional; Region: glgA; PRK00654 758793016693 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 758793016694 ADP-binding pocket [chemical binding]; other site 758793016695 homodimer interface [polypeptide binding]; other site 758793016696 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 758793016697 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 758793016698 ligand binding site; other site 758793016699 oligomer interface; other site 758793016700 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 758793016701 dimer interface [polypeptide binding]; other site 758793016702 N-terminal domain interface [polypeptide binding]; other site 758793016703 sulfate 1 binding site; other site 758793016704 pyridoxamine kinase; Validated; Region: PRK05756 758793016705 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 758793016706 dimer interface [polypeptide binding]; other site 758793016707 pyridoxal binding site [chemical binding]; other site 758793016708 ATP binding site [chemical binding]; other site 758793016709 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 758793016710 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793016711 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793016712 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793016713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793016714 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793016715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016717 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793016718 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 758793016719 TAP-like protein; Region: Abhydrolase_4; pfam08386 758793016720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 758793016721 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 758793016722 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 758793016723 shikimate binding site; other site 758793016724 NAD(P) binding site [chemical binding]; other site 758793016725 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 758793016726 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 758793016727 Sulfate transporter family; Region: Sulfate_transp; pfam00916 758793016728 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 758793016729 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793016730 extended (e) SDRs; Region: SDR_e; cd08946 758793016731 NAD(P) binding site [chemical binding]; other site 758793016732 active site 758793016733 substrate binding site [chemical binding]; other site 758793016734 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 758793016735 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 758793016736 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 758793016737 Predicted oxidoreductase [General function prediction only]; Region: COG3573 758793016738 NIPSNAP; Region: NIPSNAP; pfam07978 758793016739 NIPSNAP; Region: NIPSNAP; pfam07978 758793016740 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 758793016741 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793016742 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793016743 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793016744 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 758793016745 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 758793016746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 758793016747 non-specific DNA binding site [nucleotide binding]; other site 758793016748 salt bridge; other site 758793016749 sequence-specific DNA binding site [nucleotide binding]; other site 758793016750 Cupin domain; Region: Cupin_2; pfam07883 758793016751 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 758793016752 aldehyde dehydrogenase family 7 member; Region: PLN02315 758793016753 tetrameric interface [polypeptide binding]; other site 758793016754 NAD binding site [chemical binding]; other site 758793016755 catalytic residues [active] 758793016756 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793016757 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793016758 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 758793016759 CoenzymeA binding site [chemical binding]; other site 758793016760 subunit interaction site [polypeptide binding]; other site 758793016761 PHB binding site; other site 758793016762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793016763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016764 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 758793016765 putative dimerization interface [polypeptide binding]; other site 758793016766 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 758793016767 CoA-transferase family III; Region: CoA_transf_3; pfam02515 758793016768 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 758793016769 active site 758793016770 catalytic residues [active] 758793016771 metal binding site [ion binding]; metal-binding site 758793016772 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793016773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016775 Acetokinase family; Region: Acetate_kinase; cl17229 758793016776 propionate/acetate kinase; Provisional; Region: PRK12379 758793016777 putative phosphoketolase; Provisional; Region: PRK05261 758793016778 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 758793016779 TPP-binding site; other site 758793016780 XFP C-terminal domain; Region: XFP_C; pfam09363 758793016781 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 758793016782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793016783 ATP binding site [chemical binding]; other site 758793016784 putative Mg++ binding site [ion binding]; other site 758793016785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 758793016786 nucleotide binding region [chemical binding]; other site 758793016787 DEAD/H associated; Region: DEAD_assoc; pfam08494 758793016788 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 758793016789 Catalytic domain of Protein Kinases; Region: PKc; cd00180 758793016790 active site 758793016791 ATP binding site [chemical binding]; other site 758793016792 substrate binding site [chemical binding]; other site 758793016793 activation loop (A-loop); other site 758793016794 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 758793016795 Phasin protein; Region: Phasin_2; pfam09361 758793016796 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 758793016797 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 758793016798 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 758793016799 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793016800 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793016801 ligand binding site [chemical binding]; other site 758793016802 flexible hinge region; other site 758793016803 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 758793016804 putative switch regulator; other site 758793016805 non-specific DNA interactions [nucleotide binding]; other site 758793016806 DNA binding site [nucleotide binding] 758793016807 sequence specific DNA binding site [nucleotide binding]; other site 758793016808 putative cAMP binding site [chemical binding]; other site 758793016809 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 758793016810 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793016811 putative C-terminal domain interface [polypeptide binding]; other site 758793016812 putative GSH binding site (G-site) [chemical binding]; other site 758793016813 putative dimer interface [polypeptide binding]; other site 758793016814 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 758793016815 putative N-terminal domain interface [polypeptide binding]; other site 758793016816 putative dimer interface [polypeptide binding]; other site 758793016817 putative substrate binding pocket (H-site) [chemical binding]; other site 758793016818 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 758793016819 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 758793016820 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 758793016821 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 758793016822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793016823 dimerization interface [polypeptide binding]; other site 758793016824 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 758793016825 dimer interface [polypeptide binding]; other site 758793016826 phosphorylation site [posttranslational modification] 758793016827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793016828 ATP binding site [chemical binding]; other site 758793016829 Mg2+ binding site [ion binding]; other site 758793016830 G-X-G motif; other site 758793016831 osmolarity response regulator; Provisional; Region: ompR; PRK09468 758793016832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016833 active site 758793016834 phosphorylation site [posttranslational modification] 758793016835 intermolecular recognition site; other site 758793016836 dimerization interface [polypeptide binding]; other site 758793016837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793016838 DNA binding site [nucleotide binding] 758793016839 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 758793016840 pseudo EF-hand loop; other site 758793016841 peptide binding pocket; other site 758793016842 Ca2+ binding site [ion binding]; other site 758793016843 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 758793016844 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 758793016845 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793016846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793016847 DNA-binding site [nucleotide binding]; DNA binding site 758793016848 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758793016849 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 758793016850 hypothetical protein; Provisional; Region: PRK11622 758793016851 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 758793016852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793016853 Walker A/P-loop; other site 758793016854 ATP binding site [chemical binding]; other site 758793016855 Q-loop/lid; other site 758793016856 ABC transporter signature motif; other site 758793016857 Walker B; other site 758793016858 D-loop; other site 758793016859 H-loop/switch region; other site 758793016860 TOBE domain; Region: TOBE_2; pfam08402 758793016861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793016862 dimer interface [polypeptide binding]; other site 758793016863 conserved gate region; other site 758793016864 putative PBP binding loops; other site 758793016865 ABC-ATPase subunit interface; other site 758793016866 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 758793016867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793016868 dimer interface [polypeptide binding]; other site 758793016869 conserved gate region; other site 758793016870 putative PBP binding loops; other site 758793016871 ABC-ATPase subunit interface; other site 758793016872 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 758793016873 active site 758793016874 catalytic residues [active] 758793016875 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 758793016876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793016877 active site 758793016878 phosphorylation site [posttranslational modification] 758793016879 intermolecular recognition site; other site 758793016880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793016881 DNA binding residues [nucleotide binding] 758793016882 dimerization interface [polypeptide binding]; other site 758793016883 Predicted integral membrane protein [Function unknown]; Region: COG0392 758793016884 Uncharacterized conserved protein [Function unknown]; Region: COG2898 758793016885 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 758793016886 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 758793016887 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 758793016888 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 758793016889 dimer interface [polypeptide binding]; other site 758793016890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793016891 metal binding site [ion binding]; metal-binding site 758793016892 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 758793016893 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 758793016894 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 758793016895 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 758793016896 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 758793016897 active site 758793016898 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 758793016899 hypothetical protein; Provisional; Region: PRK07907 758793016900 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 758793016901 metal binding site [ion binding]; metal-binding site 758793016902 putative dimer interface [polypeptide binding]; other site 758793016903 putative dehydrogenase; Provisional; Region: PRK10098 758793016904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793016905 NAD(P) binding site [chemical binding]; other site 758793016906 active site 758793016907 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793016908 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 758793016909 homotrimer interaction site [polypeptide binding]; other site 758793016910 putative active site [active] 758793016911 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 758793016912 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 758793016913 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 758793016914 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 758793016915 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 758793016916 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 758793016917 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793016918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793016919 active site 758793016920 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793016921 catalytic tetrad [active] 758793016922 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 758793016923 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 758793016924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793016925 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793016926 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 758793016927 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 758793016928 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 758793016929 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793016930 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793016931 DNA binding residues [nucleotide binding] 758793016932 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 758793016933 Predicted transcriptional regulator [Transcription]; Region: COG1959 758793016934 Transcriptional regulator; Region: Rrf2; pfam02082 758793016935 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 758793016936 selenophosphate synthetase; Provisional; Region: PRK00943 758793016937 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 758793016938 dimerization interface [polypeptide binding]; other site 758793016939 putative ATP binding site [chemical binding]; other site 758793016940 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 758793016941 Cation efflux family; Region: Cation_efflux; pfam01545 758793016942 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793016943 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793016944 Purine nucleoside permease (NUP); Region: NUP; pfam06516 758793016945 transcriptional activator FlhD; Provisional; Region: PRK02909 758793016946 transcriptional activator FlhC; Provisional; Region: PRK12860 758793016947 DNA polymerase II; Reviewed; Region: PRK05762 758793016948 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 758793016949 active site 758793016950 catalytic site [active] 758793016951 substrate binding site [chemical binding]; other site 758793016952 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 758793016953 active site 758793016954 metal-binding site 758793016955 benzoate transport; Region: 2A0115; TIGR00895 758793016956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016957 putative substrate translocation pore; other site 758793016958 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 758793016959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016960 putative substrate translocation pore; other site 758793016961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016962 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 758793016963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793016965 dimerization interface [polypeptide binding]; other site 758793016966 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 758793016967 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 758793016968 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 758793016969 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 758793016970 DAK2 domain; Region: Dak2; cl03685 758793016971 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 758793016972 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 758793016973 Protein of unknown function (DUF796); Region: DUF796; cl01226 758793016974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793016975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793016976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793016977 dimerization interface [polypeptide binding]; other site 758793016978 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 758793016979 active site 1 [active] 758793016980 dimer interface [polypeptide binding]; other site 758793016981 hexamer interface [polypeptide binding]; other site 758793016982 active site 2 [active] 758793016983 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 758793016984 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 758793016985 metal binding site [ion binding]; metal-binding site 758793016986 substrate binding pocket [chemical binding]; other site 758793016987 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 758793016988 classical (c) SDRs; Region: SDR_c; cd05233 758793016989 NAD(P) binding site [chemical binding]; other site 758793016990 active site 758793016991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793016992 metabolite-proton symporter; Region: 2A0106; TIGR00883 758793016993 putative substrate translocation pore; other site 758793016994 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 758793016995 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 758793016996 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793016997 MarR family; Region: MarR_2; pfam12802 758793016998 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 758793016999 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 758793017000 histidinol dehydrogenase; Region: hisD; TIGR00069 758793017001 NAD binding site [chemical binding]; other site 758793017002 dimerization interface [polypeptide binding]; other site 758793017003 product binding site; other site 758793017004 substrate binding site [chemical binding]; other site 758793017005 zinc binding site [ion binding]; other site 758793017006 catalytic residues [active] 758793017007 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 758793017008 dimerization interface [polypeptide binding]; other site 758793017009 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 758793017010 ligand binding site [chemical binding]; other site 758793017011 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 758793017012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793017013 NAD(P) binding site [chemical binding]; other site 758793017014 active site 758793017015 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793017016 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793017017 conserved cys residue [active] 758793017018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793017019 catalytic residue [active] 758793017020 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 758793017021 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 758793017022 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793017023 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793017024 NAD(P) binding site [chemical binding]; other site 758793017025 catalytic residues [active] 758793017026 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793017027 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 758793017028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793017029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793017031 dimerization interface [polypeptide binding]; other site 758793017032 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 758793017033 nucleoside/Zn binding site; other site 758793017034 dimer interface [polypeptide binding]; other site 758793017035 catalytic motif [active] 758793017036 Protein of unknown function (DUF429); Region: DUF429; cl12046 758793017037 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793017038 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793017039 trimer interface [polypeptide binding]; other site 758793017040 eyelet of channel; other site 758793017041 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793017042 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793017043 NAD(P) binding site [chemical binding]; other site 758793017044 catalytic residues [active] 758793017045 Cytochrome c; Region: Cytochrom_C; pfam00034 758793017046 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 758793017047 Cytochrome c; Region: Cytochrom_C; pfam00034 758793017048 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 758793017049 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 758793017050 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793017051 Methylamine utilisation protein MauE; Region: MauE; pfam07291 758793017052 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 758793017053 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 758793017054 Helix-turn-helix domain; Region: HTH_18; pfam12833 758793017055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793017056 Flavin Reductases; Region: FlaRed; cl00801 758793017057 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 758793017058 SnoaL-like domain; Region: SnoaL_3; pfam13474 758793017059 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 758793017060 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793017061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017062 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793017063 dimerization interface [polypeptide binding]; other site 758793017064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793017065 D-galactonate transporter; Region: 2A0114; TIGR00893 758793017066 putative substrate translocation pore; other site 758793017067 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 758793017068 active site 758793017069 homotetramer interface [polypeptide binding]; other site 758793017070 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 758793017071 active site 758793017072 homotetramer interface [polypeptide binding]; other site 758793017073 H-NS histone family; Region: Histone_HNS; pfam00816 758793017074 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 758793017075 H-NS histone family; Region: Histone_HNS; pfam00816 758793017076 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 758793017077 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 758793017078 active site 758793017079 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 758793017080 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 758793017081 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 758793017082 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 758793017083 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 758793017084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793017085 dimer interface [polypeptide binding]; other site 758793017086 phosphorylation site [posttranslational modification] 758793017087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793017088 ATP binding site [chemical binding]; other site 758793017089 Mg2+ binding site [ion binding]; other site 758793017090 G-X-G motif; other site 758793017091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793017092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793017093 active site 758793017094 phosphorylation site [posttranslational modification] 758793017095 intermolecular recognition site; other site 758793017096 dimerization interface [polypeptide binding]; other site 758793017097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793017098 DNA binding site [nucleotide binding] 758793017099 methionine sulfoxide reductase B; Provisional; Region: PRK00222 758793017100 SelR domain; Region: SelR; pfam01641 758793017101 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 758793017102 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 758793017103 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 758793017104 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793017105 catalytic residues [active] 758793017106 methionine sulfoxide reductase A; Provisional; Region: PRK13014 758793017107 transaminase; Validated; Region: PRK07324 758793017108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793017109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017110 homodimer interface [polypeptide binding]; other site 758793017111 catalytic residue [active] 758793017112 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 758793017113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793017115 dimerization interface [polypeptide binding]; other site 758793017116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 758793017117 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793017118 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 758793017119 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 758793017120 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 758793017121 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793017122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793017123 DNA-binding site [nucleotide binding]; DNA binding site 758793017124 Ferritin-like domain; Region: Ferritin; pfam00210 758793017125 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 758793017126 dinuclear metal binding motif [ion binding]; other site 758793017127 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 758793017128 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 758793017129 dimer interface [polypeptide binding]; other site 758793017130 decamer (pentamer of dimers) interface [polypeptide binding]; other site 758793017131 catalytic triad [active] 758793017132 amino acid transporter; Region: 2A0306; TIGR00909 758793017133 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 758793017134 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 758793017135 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 758793017136 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 758793017137 oxyanion hole [active] 758793017138 Amidohydrolase; Region: Amidohydro_5; pfam13594 758793017139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 758793017140 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 758793017141 Coenzyme A transferase; Region: CoA_trans; smart00882 758793017142 Coenzyme A transferase; Region: CoA_trans; cl17247 758793017143 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 758793017144 potassium uptake protein; Region: kup; TIGR00794 758793017145 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 758793017146 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 758793017147 shikimate binding site; other site 758793017148 NAD(P) binding site [chemical binding]; other site 758793017149 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793017150 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793017151 Walker A/P-loop; other site 758793017152 ATP binding site [chemical binding]; other site 758793017153 Q-loop/lid; other site 758793017154 ABC transporter signature motif; other site 758793017155 Walker B; other site 758793017156 D-loop; other site 758793017157 H-loop/switch region; other site 758793017158 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793017159 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793017160 TM-ABC transporter signature motif; other site 758793017161 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793017162 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793017163 Walker A/P-loop; other site 758793017164 ATP binding site [chemical binding]; other site 758793017165 Q-loop/lid; other site 758793017166 ABC transporter signature motif; other site 758793017167 Walker B; other site 758793017168 D-loop; other site 758793017169 H-loop/switch region; other site 758793017170 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793017171 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793017172 TM-ABC transporter signature motif; other site 758793017173 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793017174 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 758793017175 putative ligand binding site [chemical binding]; other site 758793017176 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 758793017177 RNA polymerase sigma factor; Provisional; Region: PRK12533 758793017178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793017179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793017180 DNA binding residues [nucleotide binding] 758793017181 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 758793017182 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 758793017183 active site 758793017184 metal binding site [ion binding]; metal-binding site 758793017185 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 758793017186 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 758793017187 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 758793017188 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 758793017189 dimer interface [polypeptide binding]; other site 758793017190 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 758793017191 active site 758793017192 Fe binding site [ion binding]; other site 758793017193 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 758793017194 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 758793017195 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 758793017196 Protein phosphatase 2C; Region: PP2C; pfam00481 758793017197 active site 758793017198 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 758793017199 Protein of unknown function (DUF497); Region: DUF497; pfam04365 758793017200 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 758793017201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793017202 Walker A motif; other site 758793017203 ATP binding site [chemical binding]; other site 758793017204 Walker B motif; other site 758793017205 arginine finger; other site 758793017206 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793017207 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793017208 ligand binding site [chemical binding]; other site 758793017209 flexible hinge region; other site 758793017210 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793017211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793017212 ligand binding site [chemical binding]; other site 758793017213 flexible hinge region; other site 758793017214 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 758793017215 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 758793017216 putative active site [active] 758793017217 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 758793017218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793017219 Walker A/P-loop; other site 758793017220 ATP binding site [chemical binding]; other site 758793017221 Q-loop/lid; other site 758793017222 ABC transporter signature motif; other site 758793017223 Walker B; other site 758793017224 D-loop; other site 758793017225 H-loop/switch region; other site 758793017226 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 758793017227 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 758793017228 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 758793017229 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793017230 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793017231 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 758793017232 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 758793017233 phosphopeptide binding site; other site 758793017234 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 758793017235 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 758793017236 phosphopeptide binding site; other site 758793017237 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793017238 PUA domain; Region: PUA; cl00607 758793017239 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 758793017240 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 758793017241 Caspase domain; Region: Peptidase_C14; pfam00656 758793017242 active site 758793017243 Uncharacterized conserved protein [Function unknown]; Region: COG1262 758793017244 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 758793017245 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 758793017246 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 758793017247 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 758793017248 HPP family; Region: HPP; pfam04982 758793017249 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 758793017250 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 758793017251 MarR family; Region: MarR_2; pfam12802 758793017252 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 758793017253 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 758793017254 Cl- selectivity filter; other site 758793017255 Cl- binding residues [ion binding]; other site 758793017256 pore gating glutamate residue; other site 758793017257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 758793017258 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793017259 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793017260 active site 758793017261 catalytic tetrad [active] 758793017262 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 758793017263 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 758793017264 PRC-barrel domain; Region: PRC; pfam05239 758793017265 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 758793017266 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 758793017267 NADP binding site [chemical binding]; other site 758793017268 dimer interface [polypeptide binding]; other site 758793017269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793017270 dimerization interface [polypeptide binding]; other site 758793017271 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793017272 dimer interface [polypeptide binding]; other site 758793017273 putative CheW interface [polypeptide binding]; other site 758793017274 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 758793017275 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 758793017276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793017277 catalytic residue [active] 758793017278 NAD-dependent deacetylase; Provisional; Region: PRK05333 758793017279 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 758793017280 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 758793017281 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 758793017282 putative NAD(P) binding site [chemical binding]; other site 758793017283 catalytic Zn binding site [ion binding]; other site 758793017284 structural Zn binding site [ion binding]; other site 758793017285 Uncharacterized conserved protein [Function unknown]; Region: COG3791 758793017286 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 758793017287 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793017288 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793017289 conserved cys residue [active] 758793017290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793017291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793017292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 758793017293 Zn2+ binding site [ion binding]; other site 758793017294 Mg2+ binding site [ion binding]; other site 758793017295 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 758793017296 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 758793017297 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793017298 Cytochrome c553 [Energy production and conversion]; Region: COG2863 758793017299 Cytochrome c; Region: Cytochrom_C; cl11414 758793017300 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 758793017301 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 758793017302 D-pathway; other site 758793017303 Low-spin heme binding site [chemical binding]; other site 758793017304 Putative water exit pathway; other site 758793017305 Binuclear center (active site) [active] 758793017306 K-pathway; other site 758793017307 Putative proton exit pathway; other site 758793017308 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 758793017309 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 758793017310 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793017311 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 758793017312 Cytochrome c; Region: Cytochrom_C; pfam00034 758793017313 Cytochrome c; Region: Cytochrom_C; cl11414 758793017314 Cytochrome c; Region: Cytochrom_C; cl11414 758793017315 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 758793017316 GAF domain; Region: GAF; pfam01590 758793017317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793017318 Walker A motif; other site 758793017319 ATP binding site [chemical binding]; other site 758793017320 Walker B motif; other site 758793017321 arginine finger; other site 758793017322 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 758793017323 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 758793017324 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 758793017325 heme-binding site [chemical binding]; other site 758793017326 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 758793017327 FAD binding pocket [chemical binding]; other site 758793017328 FAD binding motif [chemical binding]; other site 758793017329 phosphate binding motif [ion binding]; other site 758793017330 beta-alpha-beta structure motif; other site 758793017331 NAD binding pocket [chemical binding]; other site 758793017332 Heme binding pocket [chemical binding]; other site 758793017333 Uncharacterized conserved protein [Function unknown]; Region: COG2128 758793017334 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 758793017335 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 758793017336 NnrS protein; Region: NnrS; pfam05940 758793017337 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 758793017338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793017339 putative substrate translocation pore; other site 758793017340 outer membrane porin, OprD family; Region: OprD; pfam03573 758793017341 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 758793017342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793017343 Walker A/P-loop; other site 758793017344 ATP binding site [chemical binding]; other site 758793017345 Q-loop/lid; other site 758793017346 ABC transporter signature motif; other site 758793017347 Walker B; other site 758793017348 D-loop; other site 758793017349 H-loop/switch region; other site 758793017350 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 758793017351 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 758793017352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 758793017353 Walker A/P-loop; other site 758793017354 ATP binding site [chemical binding]; other site 758793017355 Q-loop/lid; other site 758793017356 ABC transporter signature motif; other site 758793017357 Walker B; other site 758793017358 D-loop; other site 758793017359 H-loop/switch region; other site 758793017360 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 758793017361 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 758793017362 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 758793017363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793017364 dimer interface [polypeptide binding]; other site 758793017365 conserved gate region; other site 758793017366 putative PBP binding loops; other site 758793017367 ABC-ATPase subunit interface; other site 758793017368 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 758793017369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793017370 dimer interface [polypeptide binding]; other site 758793017371 conserved gate region; other site 758793017372 putative PBP binding loops; other site 758793017373 ABC-ATPase subunit interface; other site 758793017374 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 758793017375 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 758793017376 peptide binding site [polypeptide binding]; other site 758793017377 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 758793017378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017379 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 758793017380 putative dimerization interface [polypeptide binding]; other site 758793017381 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 758793017382 putative dimer interface [polypeptide binding]; other site 758793017383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793017384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793017385 classical (c) SDRs; Region: SDR_c; cd05233 758793017386 NAD(P) binding site [chemical binding]; other site 758793017387 active site 758793017388 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 758793017389 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 758793017390 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 758793017391 Sulfate transporter family; Region: Sulfate_transp; pfam00916 758793017392 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 758793017393 putative hydrophobic ligand binding site [chemical binding]; other site 758793017394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793017395 putative DNA binding site [nucleotide binding]; other site 758793017396 putative Zn2+ binding site [ion binding]; other site 758793017397 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 758793017398 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 758793017399 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 758793017400 active site 758793017401 Zn binding site [ion binding]; other site 758793017402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793017403 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 758793017404 substrate binding pocket [chemical binding]; other site 758793017405 membrane-bound complex binding site; other site 758793017406 hinge residues; other site 758793017407 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 758793017408 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793017409 GAF domain; Region: GAF; pfam01590 758793017410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793017411 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793017412 metal binding site [ion binding]; metal-binding site 758793017413 active site 758793017414 I-site; other site 758793017415 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 758793017416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793017417 putative substrate translocation pore; other site 758793017418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793017419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793017420 NAD(P) binding site [chemical binding]; other site 758793017421 active site 758793017422 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 758793017423 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793017424 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793017425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017426 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 758793017427 putative dimerization interface [polypeptide binding]; other site 758793017428 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 758793017429 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 758793017430 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 758793017431 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 758793017432 catalytic residues [active] 758793017433 Flagellar protein YcgR; Region: YcgR_2; pfam12945 758793017434 PilZ domain; Region: PilZ; pfam07238 758793017435 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 758793017436 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 758793017437 putative active site [active] 758793017438 Predicted metalloprotease [General function prediction only]; Region: COG2321 758793017439 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 758793017440 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 758793017441 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 758793017442 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 758793017443 Predicted permease; Region: DUF318; cl17795 758793017444 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 758793017445 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 758793017446 active site residue [active] 758793017447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 758793017448 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 758793017449 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 758793017450 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 758793017451 GAF domain; Region: GAF; pfam01590 758793017452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793017453 Walker A motif; other site 758793017454 ATP binding site [chemical binding]; other site 758793017455 Walker B motif; other site 758793017456 arginine finger; other site 758793017457 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 758793017458 DNA-binding interface [nucleotide binding]; DNA binding site 758793017459 OpgC protein; Region: OpgC_C; pfam10129 758793017460 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 758793017461 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 758793017462 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 758793017463 active site 758793017464 SAM binding site [chemical binding]; other site 758793017465 homodimer interface [polypeptide binding]; other site 758793017466 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 758793017467 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 758793017468 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 758793017469 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 758793017470 active site 758793017471 putative homodimer interface [polypeptide binding]; other site 758793017472 SAM binding site [chemical binding]; other site 758793017473 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 758793017474 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 758793017475 precorrin-3B synthase; Region: CobG; TIGR02435 758793017476 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758793017477 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 758793017478 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 758793017479 Precorrin-8X methylmutase; Region: CbiC; pfam02570 758793017480 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 758793017481 active site 758793017482 SAM binding site [chemical binding]; other site 758793017483 homodimer interface [polypeptide binding]; other site 758793017484 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 758793017485 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 758793017486 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 758793017487 active site 758793017488 SAM binding site [chemical binding]; other site 758793017489 homodimer interface [polypeptide binding]; other site 758793017490 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 758793017491 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 758793017492 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 758793017493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 758793017494 Walker A motif; other site 758793017495 ATP binding site [chemical binding]; other site 758793017496 Walker B motif; other site 758793017497 arginine finger; other site 758793017498 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 758793017499 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 758793017500 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 758793017501 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 758793017502 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 758793017503 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 758793017504 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 758793017505 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 758793017506 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 758793017507 homodimer interface [polypeptide binding]; other site 758793017508 Walker A motif; other site 758793017509 ATP binding site [chemical binding]; other site 758793017510 hydroxycobalamin binding site [chemical binding]; other site 758793017511 Walker B motif; other site 758793017512 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 758793017513 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793017514 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 758793017515 catalytic triad [active] 758793017516 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 758793017517 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 758793017518 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 758793017519 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 758793017520 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 758793017521 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 758793017522 ornithine cyclodeaminase; Validated; Region: PRK07340 758793017523 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 758793017524 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 758793017525 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793017526 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793017527 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793017528 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793017529 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793017530 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 758793017531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793017532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017533 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 758793017534 putative effector binding pocket; other site 758793017535 putative dimerization interface [polypeptide binding]; other site 758793017536 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793017537 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 758793017538 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 758793017539 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 758793017540 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 758793017541 active site 758793017542 dimer interface [polypeptide binding]; other site 758793017543 effector binding site; other site 758793017544 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 758793017545 Walker A motif; other site 758793017546 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 758793017547 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 758793017548 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793017549 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 758793017550 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 758793017551 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793017552 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793017553 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 758793017554 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 758793017555 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793017556 substrate binding pocket [chemical binding]; other site 758793017557 membrane-bound complex binding site; other site 758793017558 hinge residues; other site 758793017559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793017560 Coenzyme A binding pocket [chemical binding]; other site 758793017561 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 758793017562 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 758793017563 conserved cys residue [active] 758793017564 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793017565 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793017566 conserved cys residue [active] 758793017567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793017568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793017569 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 758793017570 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793017571 GAF domain; Region: GAF; pfam01590 758793017572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793017573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793017574 metal binding site [ion binding]; metal-binding site 758793017575 active site 758793017576 I-site; other site 758793017577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 758793017578 hypothetical protein; Provisional; Region: PRK07482 758793017579 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793017580 inhibitor-cofactor binding pocket; inhibition site 758793017581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017582 catalytic residue [active] 758793017583 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793017584 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 758793017585 tetramerization interface [polypeptide binding]; other site 758793017586 NAD(P) binding site [chemical binding]; other site 758793017587 catalytic residues [active] 758793017588 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793017589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793017590 putative DNA binding site [nucleotide binding]; other site 758793017591 putative Zn2+ binding site [ion binding]; other site 758793017592 AsnC family; Region: AsnC_trans_reg; pfam01037 758793017593 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 758793017594 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 758793017595 putative active site [active] 758793017596 Zn binding site [ion binding]; other site 758793017597 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 758793017598 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 758793017599 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 758793017600 active site 758793017601 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 758793017602 ectoine utilization protein EutC; Validated; Region: PRK08291 758793017603 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 758793017604 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 758793017605 tetramer interface [polypeptide binding]; other site 758793017606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017607 catalytic residue [active] 758793017608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793017609 DNA-binding site [nucleotide binding]; DNA binding site 758793017610 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793017611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793017612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017613 homodimer interface [polypeptide binding]; other site 758793017614 catalytic residue [active] 758793017615 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 758793017616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793017617 substrate binding pocket [chemical binding]; other site 758793017618 membrane-bound complex binding site; other site 758793017619 hinge residues; other site 758793017620 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793017621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793017622 dimer interface [polypeptide binding]; other site 758793017623 conserved gate region; other site 758793017624 putative PBP binding loops; other site 758793017625 ABC-ATPase subunit interface; other site 758793017626 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 758793017627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793017628 dimer interface [polypeptide binding]; other site 758793017629 conserved gate region; other site 758793017630 putative PBP binding loops; other site 758793017631 ABC-ATPase subunit interface; other site 758793017632 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 758793017633 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 758793017634 Walker A/P-loop; other site 758793017635 ATP binding site [chemical binding]; other site 758793017636 Q-loop/lid; other site 758793017637 ABC transporter signature motif; other site 758793017638 Walker B; other site 758793017639 D-loop; other site 758793017640 H-loop/switch region; other site 758793017641 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 758793017642 iron-sulfur cluster [ion binding]; other site 758793017643 [2Fe-2S] cluster binding site [ion binding]; other site 758793017644 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 758793017645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793017646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793017647 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 758793017648 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 758793017649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 758793017650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793017651 ATP binding site [chemical binding]; other site 758793017652 Mg2+ binding site [ion binding]; other site 758793017653 G-X-G motif; other site 758793017654 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 758793017655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793017656 active site 758793017657 phosphorylation site [posttranslational modification] 758793017658 intermolecular recognition site; other site 758793017659 dimerization interface [polypeptide binding]; other site 758793017660 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 758793017661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793017662 active site 758793017663 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 758793017664 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 758793017665 dimer interface [polypeptide binding]; other site 758793017666 TPP-binding site [chemical binding]; other site 758793017667 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 758793017668 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 758793017669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793017670 putative DNA binding site [nucleotide binding]; other site 758793017671 putative Zn2+ binding site [ion binding]; other site 758793017672 AsnC family; Region: AsnC_trans_reg; pfam01037 758793017673 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 758793017674 Mechanosensitive ion channel; Region: MS_channel; pfam00924 758793017675 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 758793017676 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793017677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793017679 dimerization interface [polypeptide binding]; other site 758793017680 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 758793017681 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 758793017682 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793017683 Magnesium ion binding site [ion binding]; other site 758793017684 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793017685 Magnesium ion binding site [ion binding]; other site 758793017686 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 758793017687 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 758793017688 Walker A/P-loop; other site 758793017689 ATP binding site [chemical binding]; other site 758793017690 Q-loop/lid; other site 758793017691 ABC transporter signature motif; other site 758793017692 Walker B; other site 758793017693 D-loop; other site 758793017694 H-loop/switch region; other site 758793017695 TOBE domain; Region: TOBE_2; pfam08402 758793017696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758793017697 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 758793017698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793017699 dimer interface [polypeptide binding]; other site 758793017700 conserved gate region; other site 758793017701 putative PBP binding loops; other site 758793017702 ABC-ATPase subunit interface; other site 758793017703 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 758793017704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793017705 dimer interface [polypeptide binding]; other site 758793017706 conserved gate region; other site 758793017707 putative PBP binding loops; other site 758793017708 ABC-ATPase subunit interface; other site 758793017709 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 758793017710 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 758793017711 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793017712 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 758793017713 DNA-binding site [nucleotide binding]; DNA binding site 758793017714 FCD domain; Region: FCD; pfam07729 758793017715 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 758793017716 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 758793017717 putative active site pocket [active] 758793017718 metal binding site [ion binding]; metal-binding site 758793017719 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 758793017720 ATP adenylyltransferase; Region: ATP_transf; pfam09830 758793017721 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 758793017722 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 758793017723 protein binding site [polypeptide binding]; other site 758793017724 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 758793017725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 758793017726 non-specific DNA binding site [nucleotide binding]; other site 758793017727 salt bridge; other site 758793017728 sequence-specific DNA binding site [nucleotide binding]; other site 758793017729 Phasin protein; Region: Phasin_2; pfam09361 758793017730 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 758793017731 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 758793017732 FAD binding domain; Region: FAD_binding_4; pfam01565 758793017733 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793017734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793017735 DNA-binding site [nucleotide binding]; DNA binding site 758793017736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793017737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017738 homodimer interface [polypeptide binding]; other site 758793017739 catalytic residue [active] 758793017740 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 758793017741 HsdM N-terminal domain; Region: HsdM_N; pfam12161 758793017742 Methyltransferase domain; Region: Methyltransf_26; pfam13659 758793017743 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 758793017744 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 758793017745 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 758793017746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 758793017747 ATP binding site [chemical binding]; other site 758793017748 putative Mg++ binding site [ion binding]; other site 758793017749 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 758793017750 nucleotide binding region [chemical binding]; other site 758793017751 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 758793017752 ATP-binding site [chemical binding]; other site 758793017753 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 758793017754 DEAD_2; Region: DEAD_2; pfam06733 758793017755 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 758793017756 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 758793017757 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 758793017758 dimerization interface [polypeptide binding]; other site 758793017759 active site 758793017760 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 758793017761 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 758793017762 peroxiredoxin; Region: AhpC; TIGR03137 758793017763 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 758793017764 dimer interface [polypeptide binding]; other site 758793017765 decamer (pentamer of dimers) interface [polypeptide binding]; other site 758793017766 catalytic triad [active] 758793017767 peroxidatic and resolving cysteines [active] 758793017768 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 758793017769 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 758793017770 catalytic residue [active] 758793017771 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 758793017772 catalytic residues [active] 758793017773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793017774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793017775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793017776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 758793017777 dimer interface [polypeptide binding]; other site 758793017778 phosphorylation site [posttranslational modification] 758793017779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793017780 ATP binding site [chemical binding]; other site 758793017781 Mg2+ binding site [ion binding]; other site 758793017782 G-X-G motif; other site 758793017783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793017784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017785 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 758793017786 putative dimerization interface [polypeptide binding]; other site 758793017787 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 758793017788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793017789 S-adenosylmethionine binding site [chemical binding]; other site 758793017790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793017791 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 758793017792 putative dimerization interface [polypeptide binding]; other site 758793017793 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 758793017794 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 758793017795 dimer interface [polypeptide binding]; other site 758793017796 NADP binding site [chemical binding]; other site 758793017797 catalytic residues [active] 758793017798 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 758793017799 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793017800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793017801 DNA-binding site [nucleotide binding]; DNA binding site 758793017802 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793017803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017804 homodimer interface [polypeptide binding]; other site 758793017805 catalytic residue [active] 758793017806 Helix-turn-helix domain; Region: HTH_20; pfam12840 758793017807 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793017808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793017809 DNA-binding site [nucleotide binding]; DNA binding site 758793017810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793017811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017812 homodimer interface [polypeptide binding]; other site 758793017813 catalytic residue [active] 758793017814 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 758793017815 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 758793017816 putative molybdopterin cofactor binding site [chemical binding]; other site 758793017817 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 758793017818 putative molybdopterin cofactor binding site; other site 758793017819 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 758793017820 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 758793017821 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 758793017822 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 758793017823 SnoaL-like domain; Region: SnoaL_2; pfam12680 758793017824 Protein of unknown function (DUF445); Region: DUF445; pfam04286 758793017825 ACT domain; Region: ACT_3; pfam10000 758793017826 Family description; Region: ACT_7; pfam13840 758793017827 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 758793017828 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758793017829 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758793017830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793017831 Walker A/P-loop; other site 758793017832 ATP binding site [chemical binding]; other site 758793017833 Q-loop/lid; other site 758793017834 ABC transporter signature motif; other site 758793017835 Walker B; other site 758793017836 D-loop; other site 758793017837 H-loop/switch region; other site 758793017838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 758793017839 Walker A/P-loop; other site 758793017840 ATP binding site [chemical binding]; other site 758793017841 Q-loop/lid; other site 758793017842 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 758793017843 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 758793017844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 758793017845 Serine hydrolase (FSH1); Region: FSH1; pfam03959 758793017846 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 758793017847 tartrate dehydrogenase; Region: TTC; TIGR02089 758793017848 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 758793017849 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 758793017850 active site 758793017851 Zn binding site [ion binding]; other site 758793017852 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 758793017853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793017854 substrate binding pocket [chemical binding]; other site 758793017855 membrane-bound complex binding site; other site 758793017856 hinge residues; other site 758793017857 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 758793017858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017859 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793017860 dimerization interface [polypeptide binding]; other site 758793017861 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 758793017862 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 758793017863 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 758793017864 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 758793017865 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 758793017866 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 758793017867 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 758793017868 Type IV pili component [Cell motility and secretion]; Region: COG5461 758793017869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 758793017870 active site 758793017871 phosphorylation site [posttranslational modification] 758793017872 intermolecular recognition site; other site 758793017873 dimerization interface [polypeptide binding]; other site 758793017874 AAA domain; Region: AAA_31; pfam13614 758793017875 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 758793017876 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 758793017877 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 758793017878 Walker A motif; other site 758793017879 hexamer interface [polypeptide binding]; other site 758793017880 ATP binding site [chemical binding]; other site 758793017881 Walker B motif; other site 758793017882 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 758793017883 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758793017884 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 758793017885 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 758793017886 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 758793017887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 758793017888 binding surface 758793017889 TPR motif; other site 758793017890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 758793017891 binding surface 758793017892 TPR motif; other site 758793017893 Low affinity iron permease; Region: Iron_permease; pfam04120 758793017894 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 758793017895 active site 758793017896 DNA binding site [nucleotide binding] 758793017897 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793017898 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 758793017899 putative ligand binding site [chemical binding]; other site 758793017900 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793017901 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793017902 Walker A/P-loop; other site 758793017903 ATP binding site [chemical binding]; other site 758793017904 Q-loop/lid; other site 758793017905 ABC transporter signature motif; other site 758793017906 Walker B; other site 758793017907 D-loop; other site 758793017908 H-loop/switch region; other site 758793017909 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793017910 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793017911 Walker A/P-loop; other site 758793017912 ATP binding site [chemical binding]; other site 758793017913 Q-loop/lid; other site 758793017914 ABC transporter signature motif; other site 758793017915 Walker B; other site 758793017916 D-loop; other site 758793017917 H-loop/switch region; other site 758793017918 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793017919 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793017920 TM-ABC transporter signature motif; other site 758793017921 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 758793017922 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793017923 TM-ABC transporter signature motif; other site 758793017924 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 758793017925 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 758793017926 putative aminotransferase; Validated; Region: PRK07480 758793017927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 758793017928 inhibitor-cofactor binding pocket; inhibition site 758793017929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793017930 catalytic residue [active] 758793017931 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 758793017932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793017933 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 758793017934 putative dimerization interface [polypeptide binding]; other site 758793017935 putative substrate binding pocket [chemical binding]; other site 758793017936 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 758793017937 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 758793017938 putative ligand binding site [chemical binding]; other site 758793017939 NAD binding site [chemical binding]; other site 758793017940 catalytic site [active] 758793017941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793017942 D-galactonate transporter; Region: 2A0114; TIGR00893 758793017943 putative substrate translocation pore; other site 758793017944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793017945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793017946 WHG domain; Region: WHG; pfam13305 758793017947 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 758793017948 SnoaL-like domain; Region: SnoaL_3; pfam13474 758793017949 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 758793017950 dimer interface [polypeptide binding]; other site 758793017951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793017952 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 758793017953 GTP cyclohydrolase I; Provisional; Region: PLN03044 758793017954 active site 758793017955 serine O-acetyltransferase; Region: cysE; TIGR01172 758793017956 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 758793017957 trimer interface [polypeptide binding]; other site 758793017958 active site 758793017959 substrate binding site [chemical binding]; other site 758793017960 CoA binding site [chemical binding]; other site 758793017961 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 758793017962 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 758793017963 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 758793017964 putative NAD(P) binding site [chemical binding]; other site 758793017965 homodimer interface [polypeptide binding]; other site 758793017966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793017967 Coenzyme A binding pocket [chemical binding]; other site 758793017968 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 758793017969 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 758793017970 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 758793017971 dimer interface [polypeptide binding]; other site 758793017972 NADP binding site [chemical binding]; other site 758793017973 catalytic residues [active] 758793017974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793017975 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793017976 putative substrate translocation pore; other site 758793017977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793017978 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 758793017979 Ligand Binding Site [chemical binding]; other site 758793017980 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 758793017981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793017982 ligand binding site [chemical binding]; other site 758793017983 flexible hinge region; other site 758793017984 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 758793017985 putative switch regulator; other site 758793017986 non-specific DNA interactions [nucleotide binding]; other site 758793017987 DNA binding site [nucleotide binding] 758793017988 sequence specific DNA binding site [nucleotide binding]; other site 758793017989 putative cAMP binding site [chemical binding]; other site 758793017990 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 758793017991 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 758793017992 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 758793017993 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 758793017994 N-terminal plug; other site 758793017995 ligand-binding site [chemical binding]; other site 758793017996 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 758793017997 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 758793017998 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 758793017999 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 758793018000 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 758793018001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793018002 putative substrate translocation pore; other site 758793018003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793018004 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 758793018005 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 758793018006 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 758793018007 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 758793018008 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793018009 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793018010 conserved cys residue [active] 758793018011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018012 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 758793018013 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 758793018014 substrate binding site [chemical binding]; other site 758793018015 catalytic Zn binding site [ion binding]; other site 758793018016 NAD binding site [chemical binding]; other site 758793018017 structural Zn binding site [ion binding]; other site 758793018018 dimer interface [polypeptide binding]; other site 758793018019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793018020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793018021 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793018022 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793018023 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793018024 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793018025 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793018026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018027 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793018028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018029 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793018030 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 758793018031 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 758793018032 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 758793018033 Serine hydrolase; Region: Ser_hydrolase; pfam06821 758793018034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793018035 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758793018036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793018037 DNA-binding site [nucleotide binding]; DNA binding site 758793018038 UTRA domain; Region: UTRA; pfam07702 758793018039 putative oxidoreductase; Provisional; Region: PRK08275 758793018040 L-aspartate oxidase; Provisional; Region: PRK06175 758793018041 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 758793018042 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 758793018043 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 758793018044 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 758793018045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793018046 substrate binding pocket [chemical binding]; other site 758793018047 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 758793018048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793018049 dimer interface [polypeptide binding]; other site 758793018050 conserved gate region; other site 758793018051 putative PBP binding loops; other site 758793018052 ABC-ATPase subunit interface; other site 758793018053 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 758793018054 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 758793018055 Walker A/P-loop; other site 758793018056 ATP binding site [chemical binding]; other site 758793018057 Q-loop/lid; other site 758793018058 ABC transporter signature motif; other site 758793018059 Walker B; other site 758793018060 D-loop; other site 758793018061 H-loop/switch region; other site 758793018062 HEAT repeats; Region: HEAT_2; pfam13646 758793018063 HEAT repeats; Region: HEAT_2; pfam13646 758793018064 HEAT repeats; Region: HEAT_2; pfam13646 758793018065 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 758793018066 hydrophobic ligand binding site; other site 758793018067 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 758793018068 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 758793018069 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 758793018070 homodimer interface [polypeptide binding]; other site 758793018071 NAD binding pocket [chemical binding]; other site 758793018072 ATP binding pocket [chemical binding]; other site 758793018073 Mg binding site [ion binding]; other site 758793018074 active-site loop [active] 758793018075 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 758793018076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 758793018077 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 758793018078 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 758793018079 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 758793018080 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 758793018081 active site 758793018082 LssY C-terminus; Region: LssY_C; pfam14067 758793018083 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 758793018084 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 758793018085 G1 box; other site 758793018086 putative GEF interaction site [polypeptide binding]; other site 758793018087 GTP/Mg2+ binding site [chemical binding]; other site 758793018088 Switch I region; other site 758793018089 G2 box; other site 758793018090 G3 box; other site 758793018091 Switch II region; other site 758793018092 G4 box; other site 758793018093 G5 box; other site 758793018094 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 758793018095 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 758793018096 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 758793018097 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 758793018098 selenocysteine synthase; Provisional; Region: PRK04311 758793018099 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 758793018100 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 758793018101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 758793018102 catalytic residue [active] 758793018103 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 758793018104 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 758793018105 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 758793018106 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 758793018107 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 758793018108 PAC2 family; Region: PAC2; cl00847 758793018109 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 758793018110 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 758793018111 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 758793018112 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 758793018113 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 758793018114 molybdopterin cofactor binding site; other site 758793018115 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 758793018116 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 758793018117 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793018118 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793018119 trimer interface [polypeptide binding]; other site 758793018120 eyelet of channel; other site 758793018121 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 758793018122 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 758793018123 active site 758793018124 catalytic site [active] 758793018125 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 758793018126 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 758793018127 active site 758793018128 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 758793018129 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 758793018130 Transglutaminase/protease-like homologues; Region: TGc; smart00460 758793018131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 758793018132 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 758793018133 Uncharacterized conserved protein [Function unknown]; Region: COG2308 758793018134 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 758793018135 active site 758793018136 catalytic site [active] 758793018137 substrate binding site [chemical binding]; other site 758793018138 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 758793018139 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 758793018140 GIY-YIG motif/motif A; other site 758793018141 active site 758793018142 catalytic site [active] 758793018143 putative DNA binding site [nucleotide binding]; other site 758793018144 metal binding site [ion binding]; metal-binding site 758793018145 short chain dehydrogenase; Provisional; Region: PRK12937 758793018146 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 758793018147 NADP binding site [chemical binding]; other site 758793018148 homodimer interface [polypeptide binding]; other site 758793018149 active site 758793018150 substrate binding site [chemical binding]; other site 758793018151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793018152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793018153 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 758793018154 putative effector binding pocket; other site 758793018155 putative dimerization interface [polypeptide binding]; other site 758793018156 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 758793018157 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 758793018158 putative catalytic site [active] 758793018159 putative metal binding site [ion binding]; other site 758793018160 putative phosphate binding site [ion binding]; other site 758793018161 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 758793018162 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 758793018163 putative active site [active] 758793018164 catalytic site [active] 758793018165 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 758793018166 putative active site [active] 758793018167 catalytic site [active] 758793018168 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 758793018169 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758793018170 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 758793018171 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 758793018172 Cl- selectivity filter; other site 758793018173 Cl- binding residues [ion binding]; other site 758793018174 pore gating glutamate residue; other site 758793018175 dimer interface [polypeptide binding]; other site 758793018176 H+/Cl- coupling transport residue; other site 758793018177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793018178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793018179 active site 758793018180 catalytic tetrad [active] 758793018181 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 758793018182 Response regulator receiver domain; Region: Response_reg; pfam00072 758793018183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793018184 active site 758793018185 phosphorylation site [posttranslational modification] 758793018186 intermolecular recognition site; other site 758793018187 dimerization interface [polypeptide binding]; other site 758793018188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 758793018189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 758793018190 metal binding site [ion binding]; metal-binding site 758793018191 active site 758793018192 I-site; other site 758793018193 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 758793018194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793018195 phosphorylation site [posttranslational modification] 758793018196 intermolecular recognition site; other site 758793018197 CheB methylesterase; Region: CheB_methylest; pfam01339 758793018198 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 758793018199 putative binding surface; other site 758793018200 active site 758793018201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793018202 ATP binding site [chemical binding]; other site 758793018203 Mg2+ binding site [ion binding]; other site 758793018204 G-X-G motif; other site 758793018205 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 758793018206 Response regulator receiver domain; Region: Response_reg; pfam00072 758793018207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793018208 active site 758793018209 phosphorylation site [posttranslational modification] 758793018210 intermolecular recognition site; other site 758793018211 dimerization interface [polypeptide binding]; other site 758793018212 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 758793018213 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 758793018214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 758793018215 S-adenosylmethionine binding site [chemical binding]; other site 758793018216 Tetratricopeptide repeat; Region: TPR_2; pfam07719 758793018217 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 758793018218 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 758793018219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793018220 dimerization interface [polypeptide binding]; other site 758793018221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793018222 dimer interface [polypeptide binding]; other site 758793018223 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 758793018224 putative CheW interface [polypeptide binding]; other site 758793018225 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 758793018226 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 758793018227 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 758793018228 classical (c) SDRs; Region: SDR_c; cd05233 758793018229 NAD(P) binding site [chemical binding]; other site 758793018230 active site 758793018231 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 758793018232 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793018233 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793018234 DNA binding site [nucleotide binding] 758793018235 domain linker motif; other site 758793018236 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 758793018237 putative dimerization interface [polypeptide binding]; other site 758793018238 putative ligand binding site [chemical binding]; other site 758793018239 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 758793018240 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 758793018241 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 758793018242 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 758793018243 active site 758793018244 SnoaL-like domain; Region: SnoaL_2; pfam12680 758793018245 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 758793018246 Phosphoesterase family; Region: Phosphoesterase; pfam04185 758793018247 Domain of unknown function (DUF756); Region: DUF756; pfam05506 758793018248 Domain of unknown function (DUF756); Region: DUF756; pfam05506 758793018249 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 758793018250 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 758793018251 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793018252 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 758793018253 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 758793018254 Walker A/P-loop; other site 758793018255 ATP binding site [chemical binding]; other site 758793018256 Q-loop/lid; other site 758793018257 ABC transporter signature motif; other site 758793018258 Walker B; other site 758793018259 D-loop; other site 758793018260 H-loop/switch region; other site 758793018261 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 758793018262 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 758793018263 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 758793018264 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 758793018265 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 758793018266 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 758793018267 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793018268 acyl-activating enzyme (AAE) consensus motif; other site 758793018269 AMP binding site [chemical binding]; other site 758793018270 active site 758793018271 CoA binding site [chemical binding]; other site 758793018272 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 758793018273 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 758793018274 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793018275 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793018276 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793018277 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793018278 TM-ABC transporter signature motif; other site 758793018279 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793018280 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793018281 TM-ABC transporter signature motif; other site 758793018282 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793018283 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793018284 Walker A/P-loop; other site 758793018285 ATP binding site [chemical binding]; other site 758793018286 Q-loop/lid; other site 758793018287 ABC transporter signature motif; other site 758793018288 Walker B; other site 758793018289 D-loop; other site 758793018290 H-loop/switch region; other site 758793018291 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793018292 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 758793018293 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793018294 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 758793018295 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 758793018296 short chain dehydrogenase; Provisional; Region: PRK12829 758793018297 classical (c) SDRs; Region: SDR_c; cd05233 758793018298 NAD(P) binding site [chemical binding]; other site 758793018299 active site 758793018300 Transcriptional regulators [Transcription]; Region: GntR; COG1802 758793018301 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793018302 DNA-binding site [nucleotide binding]; DNA binding site 758793018303 FCD domain; Region: FCD; pfam07729 758793018304 Response regulator receiver domain; Region: Response_reg; pfam00072 758793018305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793018306 active site 758793018307 phosphorylation site [posttranslational modification] 758793018308 intermolecular recognition site; other site 758793018309 dimerization interface [polypeptide binding]; other site 758793018310 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 758793018311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793018312 putative active site [active] 758793018313 heme pocket [chemical binding]; other site 758793018314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793018315 dimer interface [polypeptide binding]; other site 758793018316 phosphorylation site [posttranslational modification] 758793018317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793018318 ATP binding site [chemical binding]; other site 758793018319 Mg2+ binding site [ion binding]; other site 758793018320 G-X-G motif; other site 758793018321 Response regulator receiver domain; Region: Response_reg; pfam00072 758793018322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793018323 active site 758793018324 phosphorylation site [posttranslational modification] 758793018325 intermolecular recognition site; other site 758793018326 dimerization interface [polypeptide binding]; other site 758793018327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793018328 dimer interface [polypeptide binding]; other site 758793018329 phosphorylation site [posttranslational modification] 758793018330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793018331 ATP binding site [chemical binding]; other site 758793018332 Mg2+ binding site [ion binding]; other site 758793018333 G-X-G motif; other site 758793018334 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 758793018335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793018336 ATP binding site [chemical binding]; other site 758793018337 Mg2+ binding site [ion binding]; other site 758793018338 G-X-G motif; other site 758793018339 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 758793018340 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 758793018341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 758793018342 ATP binding site [chemical binding]; other site 758793018343 Mg2+ binding site [ion binding]; other site 758793018344 G-X-G motif; other site 758793018345 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 758793018346 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 758793018347 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 758793018348 Response regulator receiver domain; Region: Response_reg; pfam00072 758793018349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793018350 active site 758793018351 phosphorylation site [posttranslational modification] 758793018352 intermolecular recognition site; other site 758793018353 dimerization interface [polypeptide binding]; other site 758793018354 xanthine permease; Region: pbuX; TIGR03173 758793018355 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 758793018356 Peptidase family M23; Region: Peptidase_M23; pfam01551 758793018357 Transposase, Mutator family; Region: Transposase_mut; pfam00872 758793018358 Transposase, Mutator family; Region: Transposase_mut; pfam00872 758793018359 Transposase, Mutator family; Region: Transposase_mut; pfam00872 758793018360 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 758793018361 IS2 transposase TnpB; Reviewed; Region: PRK09409 758793018362 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 758793018363 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 758793018364 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 758793018365 DNA binding site [nucleotide binding] 758793018366 active site 758793018367 Int/Topo IB signature motif; other site 758793018368 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 758793018369 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 758793018370 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 758793018371 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 758793018372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 758793018373 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758793018374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 758793018375 DNA binding residues [nucleotide binding] 758793018376 DNA primase; Validated; Region: dnaG; PRK05667 758793018377 CHC2 zinc finger; Region: zf-CHC2; pfam01807 758793018378 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 758793018379 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 758793018380 active site 758793018381 metal binding site [ion binding]; metal-binding site 758793018382 interdomain interaction site; other site 758793018383 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 758793018384 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 758793018385 Yqey-like protein; Region: YqeY; pfam09424 758793018386 Predicted flavoproteins [General function prediction only]; Region: COG2081 758793018387 UGMP family protein; Validated; Region: PRK09604 758793018388 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 758793018389 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 758793018390 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 758793018391 C-terminal domain interface [polypeptide binding]; other site 758793018392 GSH binding site (G-site) [chemical binding]; other site 758793018393 dimer interface [polypeptide binding]; other site 758793018394 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 758793018395 dimer interface [polypeptide binding]; other site 758793018396 N-terminal domain interface [polypeptide binding]; other site 758793018397 putative substrate binding pocket (H-site) [chemical binding]; other site 758793018398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793018399 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793018400 putative substrate translocation pore; other site 758793018401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793018402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793018403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 758793018404 dimerization interface [polypeptide binding]; other site 758793018405 putative GTP cyclohydrolase; Provisional; Region: PRK13674 758793018406 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 758793018407 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 758793018408 TPP-binding site; other site 758793018409 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 758793018410 PYR/PP interface [polypeptide binding]; other site 758793018411 dimer interface [polypeptide binding]; other site 758793018412 TPP binding site [chemical binding]; other site 758793018413 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793018414 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 758793018415 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 758793018416 substrate binding pocket [chemical binding]; other site 758793018417 chain length determination region; other site 758793018418 substrate-Mg2+ binding site; other site 758793018419 catalytic residues [active] 758793018420 aspartate-rich region 1; other site 758793018421 active site lid residues [active] 758793018422 aspartate-rich region 2; other site 758793018423 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 758793018424 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793018425 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 758793018426 [2Fe-2S] cluster binding site [ion binding]; other site 758793018427 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 758793018428 alpha subunit interface [polypeptide binding]; other site 758793018429 active site 758793018430 substrate binding site [chemical binding]; other site 758793018431 Fe binding site [ion binding]; other site 758793018432 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 758793018433 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 758793018434 active site residue [active] 758793018435 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 758793018436 active site residue [active] 758793018437 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 758793018438 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 758793018439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793018440 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 758793018441 DNA polymerase I; Provisional; Region: PRK05755 758793018442 active site 758793018443 putative 5' ssDNA interaction site; other site 758793018444 metal binding site 3; metal-binding site 758793018445 metal binding site 1 [ion binding]; metal-binding site 758793018446 metal binding site 2 [ion binding]; metal-binding site 758793018447 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 758793018448 putative DNA binding site [nucleotide binding]; other site 758793018449 putative metal binding site [ion binding]; other site 758793018450 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 758793018451 active site 758793018452 catalytic site [active] 758793018453 substrate binding site [chemical binding]; other site 758793018454 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 758793018455 active site 758793018456 DNA binding site [nucleotide binding] 758793018457 catalytic site [active] 758793018458 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 758793018459 AMP nucleosidase; Provisional; Region: PRK08292 758793018460 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 758793018461 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 758793018462 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 758793018463 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 758793018464 putative active site [active] 758793018465 putative substrate binding site [chemical binding]; other site 758793018466 ATP binding site [chemical binding]; other site 758793018467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793018468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793018469 putative Zn2+ binding site [ion binding]; other site 758793018470 putative DNA binding site [nucleotide binding]; other site 758793018471 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 758793018472 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 758793018473 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 758793018474 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 758793018475 molybdenum-pterin binding domain; Region: Mop; TIGR00638 758793018476 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 758793018477 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 758793018478 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 758793018479 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 758793018480 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 758793018481 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 758793018482 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 758793018483 RES domain; Region: RES; smart00953 758793018484 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 758793018485 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 758793018486 active site 758793018487 DNA binding site [nucleotide binding] 758793018488 Int/Topo IB signature motif; other site 758793018489 catalytic residues [active] 758793018490 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 758793018491 active site 758793018492 metal binding site [ion binding]; metal-binding site 758793018493 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 758793018494 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 758793018495 Ligand binding site; other site 758793018496 metal-binding site 758793018497 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 758793018498 glycogen synthase; Provisional; Region: glgA; PRK00654 758793018499 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 758793018500 ADP-binding pocket [chemical binding]; other site 758793018501 homodimer interface [polypeptide binding]; other site 758793018502 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 758793018503 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 758793018504 active site 758793018505 catalytic site [active] 758793018506 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 758793018507 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 758793018508 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 758793018509 active site 758793018510 homodimer interface [polypeptide binding]; other site 758793018511 catalytic site [active] 758793018512 acceptor binding site [chemical binding]; other site 758793018513 trehalose synthase; Region: treS_nterm; TIGR02456 758793018514 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 758793018515 active site 758793018516 catalytic site [active] 758793018517 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 758793018518 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 758793018519 glycogen branching enzyme; Provisional; Region: PRK05402 758793018520 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 758793018521 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 758793018522 active site 758793018523 catalytic site [active] 758793018524 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 758793018525 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 758793018526 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 758793018527 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 758793018528 active site 758793018529 catalytic site [active] 758793018530 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 758793018531 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 758793018532 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 758793018533 catalytic site [active] 758793018534 active site 758793018535 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 758793018536 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 758793018537 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 758793018538 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 758793018539 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 758793018540 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 758793018541 active site 758793018542 catalytic site [active] 758793018543 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 758793018544 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 758793018545 Domain of unknown function DUF21; Region: DUF21; pfam01595 758793018546 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 758793018547 Transporter associated domain; Region: CorC_HlyC; smart01091 758793018548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793018549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793018550 dimer interface [polypeptide binding]; other site 758793018551 phosphorylation site [posttranslational modification] 758793018552 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 758793018553 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 758793018554 active site 758793018555 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 758793018556 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 758793018557 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 758793018558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793018559 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793018560 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793018561 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 758793018562 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 758793018563 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 758793018564 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 758793018565 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 758793018566 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 758793018567 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 758793018568 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793018569 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 758793018570 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 758793018571 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 758793018572 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 758793018573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018574 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 758793018575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018576 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 758793018577 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 758793018578 homodimer interface [polypeptide binding]; other site 758793018579 substrate-cofactor binding pocket; other site 758793018580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793018581 catalytic residue [active] 758793018582 amidophosphoribosyltransferase; Provisional; Region: PRK09246 758793018583 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 758793018584 active site 758793018585 tetramer interface [polypeptide binding]; other site 758793018586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 758793018587 active site 758793018588 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 758793018589 Colicin V production protein; Region: Colicin_V; pfam02674 758793018590 Sporulation related domain; Region: SPOR; pfam05036 758793018591 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 758793018592 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 758793018593 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 758793018594 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 758793018595 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 758793018596 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 758793018597 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 758793018598 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 758793018599 substrate binding site [chemical binding]; other site 758793018600 active site 758793018601 catalytic residues [active] 758793018602 heterodimer interface [polypeptide binding]; other site 758793018603 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 758793018604 DNA methylase; Region: N6_N4_Mtase; pfam01555 758793018605 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 758793018606 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 758793018607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793018608 catalytic residue [active] 758793018609 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 758793018610 active site 758793018611 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 758793018612 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 758793018613 dimerization interface 3.5A [polypeptide binding]; other site 758793018614 active site 758793018615 FimV N-terminal domain; Region: FimV_core; TIGR03505 758793018616 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 758793018617 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 758793018618 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 758793018619 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 758793018620 tartrate dehydrogenase; Region: TTC; TIGR02089 758793018621 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 758793018622 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 758793018623 substrate binding site [chemical binding]; other site 758793018624 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 758793018625 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 758793018626 substrate binding site [chemical binding]; other site 758793018627 ligand binding site [chemical binding]; other site 758793018628 PemK-like protein; Region: PemK; pfam02452 758793018629 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 758793018630 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 758793018631 dimer interface [polypeptide binding]; other site 758793018632 active site 758793018633 citrylCoA binding site [chemical binding]; other site 758793018634 NADH binding [chemical binding]; other site 758793018635 cationic pore residues; other site 758793018636 oxalacetate/citrate binding site [chemical binding]; other site 758793018637 coenzyme A binding site [chemical binding]; other site 758793018638 catalytic triad [active] 758793018639 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 758793018640 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 758793018641 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 758793018642 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 758793018643 L-aspartate oxidase; Provisional; Region: PRK06175 758793018644 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 758793018645 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 758793018646 SdhC subunit interface [polypeptide binding]; other site 758793018647 proximal heme binding site [chemical binding]; other site 758793018648 cardiolipin binding site; other site 758793018649 Iron-sulfur protein interface; other site 758793018650 proximal quinone binding site [chemical binding]; other site 758793018651 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 758793018652 proximal quinone binding site [chemical binding]; other site 758793018653 SdhD (CybS) interface [polypeptide binding]; other site 758793018654 proximal heme binding site [chemical binding]; other site 758793018655 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 758793018656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793018657 DNA-binding site [nucleotide binding]; DNA binding site 758793018658 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 758793018659 malate dehydrogenase; Provisional; Region: PRK05442 758793018660 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 758793018661 NAD(P) binding site [chemical binding]; other site 758793018662 dimer interface [polypeptide binding]; other site 758793018663 malate binding site [chemical binding]; other site 758793018664 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 758793018665 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 758793018666 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 758793018667 dimer interface [polypeptide binding]; other site 758793018668 active site 758793018669 citrylCoA binding site [chemical binding]; other site 758793018670 oxalacetate/citrate binding site [chemical binding]; other site 758793018671 coenzyme A binding site [chemical binding]; other site 758793018672 catalytic triad [active] 758793018673 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 758793018674 2-methylcitrate dehydratase; Region: prpD; TIGR02330 758793018675 aconitate hydratase; Provisional; Region: acnA; PRK12881 758793018676 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 758793018677 substrate binding site [chemical binding]; other site 758793018678 ligand binding site [chemical binding]; other site 758793018679 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 758793018680 substrate binding site [chemical binding]; other site 758793018681 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 758793018682 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 758793018683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793018684 DNA-binding site [nucleotide binding]; DNA binding site 758793018685 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793018686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793018687 homodimer interface [polypeptide binding]; other site 758793018688 catalytic residue [active] 758793018689 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 758793018690 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 758793018691 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 758793018692 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793018693 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 758793018694 tetramerization interface [polypeptide binding]; other site 758793018695 NAD(P) binding site [chemical binding]; other site 758793018696 catalytic residues [active] 758793018697 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 758793018698 MarR family; Region: MarR_2; pfam12802 758793018699 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 758793018700 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 758793018701 Moco binding site; other site 758793018702 metal coordination site [ion binding]; other site 758793018703 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 758793018704 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 758793018705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793018706 active site 758793018707 phosphorylation site [posttranslational modification] 758793018708 intermolecular recognition site; other site 758793018709 dimerization interface [polypeptide binding]; other site 758793018710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793018711 DNA binding site [nucleotide binding] 758793018712 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 758793018713 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793018714 dimerization interface [polypeptide binding]; other site 758793018715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793018716 dimer interface [polypeptide binding]; other site 758793018717 phosphorylation site [posttranslational modification] 758793018718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793018719 ATP binding site [chemical binding]; other site 758793018720 Mg2+ binding site [ion binding]; other site 758793018721 G-X-G motif; other site 758793018722 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793018723 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793018724 ligand binding site [chemical binding]; other site 758793018725 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 758793018726 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793018727 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793018728 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 758793018729 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 758793018730 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 758793018731 active site residue [active] 758793018732 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 758793018733 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 758793018734 putative NAD(P) binding site [chemical binding]; other site 758793018735 active site 758793018736 putative substrate binding site [chemical binding]; other site 758793018737 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 758793018738 putative aldolase; Validated; Region: PRK08130 758793018739 intersubunit interface [polypeptide binding]; other site 758793018740 active site 758793018741 Zn2+ binding site [ion binding]; other site 758793018742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 758793018743 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 758793018744 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793018745 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793018746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793018747 DNA-binding site [nucleotide binding]; DNA binding site 758793018748 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758793018749 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758793018750 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793018751 catalytic residues [active] 758793018752 Chromate transporter; Region: Chromate_transp; pfam02417 758793018753 Chromate transporter; Region: Chromate_transp; pfam02417 758793018754 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 758793018755 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 758793018756 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 758793018757 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 758793018758 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 758793018759 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 758793018760 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 758793018761 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793018762 nucleophilic elbow; other site 758793018763 catalytic triad; other site 758793018764 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 758793018765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 758793018766 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 758793018767 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 758793018768 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 758793018769 Metal-binding active site; metal-binding site 758793018770 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 758793018771 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 758793018772 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 758793018773 putative ligand binding site [chemical binding]; other site 758793018774 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793018775 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793018776 TM-ABC transporter signature motif; other site 758793018777 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793018778 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793018779 Walker A/P-loop; other site 758793018780 ATP binding site [chemical binding]; other site 758793018781 Q-loop/lid; other site 758793018782 ABC transporter signature motif; other site 758793018783 Walker B; other site 758793018784 D-loop; other site 758793018785 H-loop/switch region; other site 758793018786 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793018787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 758793018788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 758793018789 DNA binding site [nucleotide binding] 758793018790 domain linker motif; other site 758793018791 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 758793018792 dimerization interface [polypeptide binding]; other site 758793018793 ligand binding site [chemical binding]; other site 758793018794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 758793018795 putative acyltransferase; Provisional; Region: PRK05790 758793018796 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793018797 dimer interface [polypeptide binding]; other site 758793018798 active site 758793018799 short chain dehydrogenase; Validated; Region: PRK08264 758793018800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793018801 NAD(P) binding site [chemical binding]; other site 758793018802 active site 758793018803 Transcriptional regulators [Transcription]; Region: MarR; COG1846 758793018804 MarR family; Region: MarR_2; pfam12802 758793018805 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793018806 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 758793018807 dimerization interface [polypeptide binding]; other site 758793018808 ligand binding site [chemical binding]; other site 758793018809 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 758793018810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793018811 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793018812 dimerization interface [polypeptide binding]; other site 758793018813 substrate binding pocket [chemical binding]; other site 758793018814 putative aminotransferase; Provisional; Region: PRK12414 758793018815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 758793018816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 758793018817 homodimer interface [polypeptide binding]; other site 758793018818 catalytic residue [active] 758793018819 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 758793018820 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 758793018821 substrate binding pocket [chemical binding]; other site 758793018822 membrane-bound complex binding site; other site 758793018823 hinge residues; other site 758793018824 PemK-like protein; Region: PemK; cl00995 758793018825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 758793018826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793018827 putative substrate translocation pore; other site 758793018828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793018829 Restriction endonuclease; Region: Mrr_cat; pfam04471 758793018830 Domain of unknown function DUF29; Region: DUF29; pfam01724 758793018831 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 758793018832 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 758793018833 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 758793018834 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 758793018835 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 758793018836 Uncharacterized conserved protein [Function unknown]; Region: COG5361 758793018837 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 758793018838 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 758793018839 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 758793018840 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 758793018841 metal-binding site [ion binding] 758793018842 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 758793018843 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 758793018844 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 758793018845 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 758793018846 Uncharacterized conserved protein [Function unknown]; Region: COG3246 758793018847 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 758793018848 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 758793018849 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 758793018850 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 758793018851 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 758793018852 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 758793018853 acyl-activating enzyme (AAE) consensus motif; other site 758793018854 AMP binding site [chemical binding]; other site 758793018855 active site 758793018856 CoA binding site [chemical binding]; other site 758793018857 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 758793018858 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 758793018859 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793018860 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 758793018861 conserved cys residue [active] 758793018862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018863 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 758793018864 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 758793018865 trimer interface [polypeptide binding]; other site 758793018866 eyelet of channel; other site 758793018867 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 758793018868 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 758793018869 choline-sulfatase; Region: chol_sulfatase; TIGR03417 758793018870 Sulfatase; Region: Sulfatase; cl17466 758793018871 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 758793018872 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 758793018873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793018874 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 758793018875 dimerization interface [polypeptide binding]; other site 758793018876 substrate binding pocket [chemical binding]; other site 758793018877 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 758793018878 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 758793018879 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 758793018880 putative active site [active] 758793018881 putative substrate binding site [chemical binding]; other site 758793018882 putative cosubstrate binding site; other site 758793018883 catalytic site [active] 758793018884 lipase chaperone; Provisional; Region: PRK01294 758793018885 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 758793018886 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 758793018887 Lipase (class 2); Region: Lipase_2; pfam01674 758793018888 PGAP1-like protein; Region: PGAP1; pfam07819 758793018889 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 758793018890 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 758793018891 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 758793018892 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 758793018893 FAD binding pocket [chemical binding]; other site 758793018894 FAD binding motif [chemical binding]; other site 758793018895 phosphate binding motif [ion binding]; other site 758793018896 beta-alpha-beta structure motif; other site 758793018897 NAD binding pocket [chemical binding]; other site 758793018898 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 758793018899 catalytic loop [active] 758793018900 iron binding site [ion binding]; other site 758793018901 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 758793018902 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 758793018903 [2Fe-2S] cluster binding site [ion binding]; other site 758793018904 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 758793018905 putative alpha subunit interface [polypeptide binding]; other site 758793018906 putative active site [active] 758793018907 putative substrate binding site [chemical binding]; other site 758793018908 Fe binding site [ion binding]; other site 758793018909 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 758793018910 Electron transfer flavoprotein domain; Region: ETF; pfam01012 758793018911 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 758793018912 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 758793018913 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 758793018914 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 758793018915 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 758793018916 Cysteine-rich domain; Region: CCG; pfam02754 758793018917 Cysteine-rich domain; Region: CCG; pfam02754 758793018918 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 758793018919 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 758793018920 putative active site [active] 758793018921 putative FMN binding site [chemical binding]; other site 758793018922 putative substrate binding site [chemical binding]; other site 758793018923 putative catalytic residue [active] 758793018924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 758793018925 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 758793018926 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 758793018927 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 758793018928 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 758793018929 active site 758793018930 dimer interface [polypeptide binding]; other site 758793018931 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 758793018932 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 758793018933 dimer interface [polypeptide binding]; other site 758793018934 active site 758793018935 glycine-pyridoxal phosphate binding site [chemical binding]; other site 758793018936 folate binding site [chemical binding]; other site 758793018937 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793018938 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 758793018939 conserved cys residue [active] 758793018940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018941 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 758793018942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 758793018943 Coenzyme A binding pocket [chemical binding]; other site 758793018944 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 758793018945 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 758793018946 NAD binding site [chemical binding]; other site 758793018947 catalytic Zn binding site [ion binding]; other site 758793018948 structural Zn binding site [ion binding]; other site 758793018949 transcriptional regulator BetI; Validated; Region: PRK00767 758793018950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793018951 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 758793018952 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 758793018953 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 758793018954 tetrameric interface [polypeptide binding]; other site 758793018955 NAD binding site [chemical binding]; other site 758793018956 catalytic residues [active] 758793018957 choline dehydrogenase; Validated; Region: PRK02106 758793018958 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 758793018959 benzoate transport; Region: 2A0115; TIGR00895 758793018960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793018961 putative substrate translocation pore; other site 758793018962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793018963 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 758793018964 active site 758793018965 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 758793018966 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 758793018967 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 758793018968 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793018969 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 758793018970 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 758793018971 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 758793018972 hydroxyglutarate oxidase; Provisional; Region: PRK11728 758793018973 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 758793018974 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 758793018975 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 758793018976 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793018977 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 758793018978 conserved cys residue [active] 758793018979 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 758793018980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018981 aldolase II superfamily protein; Provisional; Region: PRK07044 758793018982 intersubunit interface [polypeptide binding]; other site 758793018983 active site 758793018984 Zn2+ binding site [ion binding]; other site 758793018985 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 758793018986 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 758793018987 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 758793018988 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 758793018989 conserved cys residue [active] 758793018990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793018991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 758793018992 dimer interface [polypeptide binding]; other site 758793018993 conserved gate region; other site 758793018994 putative PBP binding loops; other site 758793018995 ABC-ATPase subunit interface; other site 758793018996 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 758793018997 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 758793018998 Walker A/P-loop; other site 758793018999 ATP binding site [chemical binding]; other site 758793019000 Q-loop/lid; other site 758793019001 ABC transporter signature motif; other site 758793019002 Walker B; other site 758793019003 D-loop; other site 758793019004 H-loop/switch region; other site 758793019005 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 758793019006 MgtC family; Region: MgtC; pfam02308 758793019007 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 758793019008 putative active cleft [active] 758793019009 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 758793019010 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 758793019011 dimer interface [polypeptide binding]; other site 758793019012 ligand binding site [chemical binding]; other site 758793019013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 758793019014 dimerization interface [polypeptide binding]; other site 758793019015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 758793019016 dimer interface [polypeptide binding]; other site 758793019017 putative CheW interface [polypeptide binding]; other site 758793019018 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 758793019019 CoenzymeA binding site [chemical binding]; other site 758793019020 subunit interaction site [polypeptide binding]; other site 758793019021 PHB binding site; other site 758793019022 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 758793019023 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 758793019024 short chain dehydrogenase; Provisional; Region: PRK06138 758793019025 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 758793019026 NAD binding site [chemical binding]; other site 758793019027 homotetramer interface [polypeptide binding]; other site 758793019028 homodimer interface [polypeptide binding]; other site 758793019029 active site 758793019030 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 758793019031 Amidohydrolase; Region: Amidohydro_2; pfam04909 758793019032 active site 758793019033 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793019034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793019035 active site 758793019036 catalytic tetrad [active] 758793019037 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 758793019038 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 758793019039 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 758793019040 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793019041 TM-ABC transporter signature motif; other site 758793019042 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 758793019043 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 758793019044 Walker A/P-loop; other site 758793019045 ATP binding site [chemical binding]; other site 758793019046 Q-loop/lid; other site 758793019047 ABC transporter signature motif; other site 758793019048 Walker B; other site 758793019049 D-loop; other site 758793019050 H-loop/switch region; other site 758793019051 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 758793019052 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 758793019053 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 758793019054 ligand binding site [chemical binding]; other site 758793019055 Transcriptional regulator [Transcription]; Region: IclR; COG1414 758793019056 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 758793019057 Bacterial transcriptional regulator; Region: IclR; pfam01614 758793019058 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 758793019059 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 758793019060 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 758793019061 Initiator Replication protein; Region: Rep_3; pfam01051 758793019062 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 758793019063 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793019064 P-loop; other site 758793019065 Magnesium ion binding site [ion binding]; other site 758793019066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 758793019067 Magnesium ion binding site [ion binding]; other site 758793019068 ParB-like nuclease domain; Region: ParB; smart00470 758793019069 Transcriptional regulators [Transcription]; Region: FadR; COG2186 758793019070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 758793019071 DNA-binding site [nucleotide binding]; DNA binding site 758793019072 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 758793019073 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 758793019074 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 758793019075 putative ligand binding site [chemical binding]; other site 758793019076 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 758793019077 TM-ABC transporter signature motif; other site 758793019078 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 758793019079 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 758793019080 TM-ABC transporter signature motif; other site 758793019081 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 758793019082 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 758793019083 Walker A/P-loop; other site 758793019084 ATP binding site [chemical binding]; other site 758793019085 Q-loop/lid; other site 758793019086 ABC transporter signature motif; other site 758793019087 Walker B; other site 758793019088 D-loop; other site 758793019089 H-loop/switch region; other site 758793019090 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 758793019091 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 758793019092 Walker A/P-loop; other site 758793019093 ATP binding site [chemical binding]; other site 758793019094 Q-loop/lid; other site 758793019095 ABC transporter signature motif; other site 758793019096 Walker B; other site 758793019097 D-loop; other site 758793019098 H-loop/switch region; other site 758793019099 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793019100 classical (c) SDRs; Region: SDR_c; cd05233 758793019101 NAD(P) binding site [chemical binding]; other site 758793019102 active site 758793019103 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 758793019104 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 758793019105 tetramer interface [polypeptide binding]; other site 758793019106 TPP-binding site [chemical binding]; other site 758793019107 heterodimer interface [polypeptide binding]; other site 758793019108 phosphorylation loop region [posttranslational modification] 758793019109 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 758793019110 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 758793019111 alpha subunit interface [polypeptide binding]; other site 758793019112 TPP binding site [chemical binding]; other site 758793019113 heterodimer interface [polypeptide binding]; other site 758793019114 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 758793019115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 758793019116 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 758793019117 active site 758793019118 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 758793019119 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 758793019120 E3 interaction surface; other site 758793019121 lipoyl attachment site [posttranslational modification]; other site 758793019122 e3 binding domain; Region: E3_binding; pfam02817 758793019123 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 758793019124 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 758793019125 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 758793019126 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793019127 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 758793019128 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 758793019129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793019130 NAD(P) binding site [chemical binding]; other site 758793019131 active site 758793019132 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 758793019133 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 758793019134 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 758793019135 shikimate binding site; other site 758793019136 NAD(P) binding site [chemical binding]; other site 758793019137 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 758793019138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793019139 putative substrate translocation pore; other site 758793019140 Predicted transcriptional regulators [Transcription]; Region: COG1733 758793019141 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 758793019142 BON domain; Region: BON; pfam04972 758793019143 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 758793019144 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 758793019145 conserved cys residue [active] 758793019146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 758793019147 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 758793019148 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 758793019149 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 758793019150 catalytic residues [active] 758793019151 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 758793019152 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 758793019153 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 758793019154 putative active site pocket [active] 758793019155 dimerization interface [polypeptide binding]; other site 758793019156 putative catalytic residue [active] 758793019157 Transcriptional regulator; Region: Rrf2; pfam02082 758793019158 Rrf2 family protein; Region: rrf2_super; TIGR00738 758793019159 Transcriptional regulator; Region: Rrf2; cl17282 758793019160 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793019161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793019162 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 758793019163 putative effector binding pocket; other site 758793019164 putative dimerization interface [polypeptide binding]; other site 758793019165 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 758793019166 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 758793019167 tetramerization interface [polypeptide binding]; other site 758793019168 NAD(P) binding site [chemical binding]; other site 758793019169 catalytic residues [active] 758793019170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793019171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793019172 DNA binding site [nucleotide binding] 758793019173 AAA ATPase domain; Region: AAA_16; pfam13191 758793019174 Predicted ATPase [General function prediction only]; Region: COG3903 758793019175 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 758793019176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 758793019177 DNA binding site [nucleotide binding] 758793019178 AAA ATPase domain; Region: AAA_16; pfam13191 758793019179 Predicted ATPase [General function prediction only]; Region: COG3903 758793019180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793019181 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 758793019182 putative active site [active] 758793019183 heme pocket [chemical binding]; other site 758793019184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793019185 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 758793019186 putative active site [active] 758793019187 heme pocket [chemical binding]; other site 758793019188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793019189 putative active site [active] 758793019190 heme pocket [chemical binding]; other site 758793019191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 758793019192 dimer interface [polypeptide binding]; other site 758793019193 phosphorylation site [posttranslational modification] 758793019194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793019195 ATP binding site [chemical binding]; other site 758793019196 Mg2+ binding site [ion binding]; other site 758793019197 G-X-G motif; other site 758793019198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793019199 Response regulator receiver domain; Region: Response_reg; pfam00072 758793019200 active site 758793019201 phosphorylation site [posttranslational modification] 758793019202 intermolecular recognition site; other site 758793019203 dimerization interface [polypeptide binding]; other site 758793019204 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 758793019205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 758793019206 active site 758793019207 phosphorylation site [posttranslational modification] 758793019208 intermolecular recognition site; other site 758793019209 dimerization interface [polypeptide binding]; other site 758793019210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 758793019211 DNA binding residues [nucleotide binding] 758793019212 dimerization interface [polypeptide binding]; other site 758793019213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793019214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793019215 MarR family; Region: MarR_2; pfam12802 758793019216 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 758793019217 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 758793019218 active site 758793019219 catalytic tetrad [active] 758793019220 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 758793019221 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 758793019222 tetramer interface [polypeptide binding]; other site 758793019223 active site 758793019224 Mg2+/Mn2+ binding site [ion binding]; other site 758793019225 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 758793019226 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 758793019227 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 758793019228 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 758793019229 HlyD family secretion protein; Region: HlyD_3; pfam13437 758793019230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 758793019231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793019232 Predicted transcriptional regulators [Transcription]; Region: COG1733 758793019233 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 758793019234 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 758793019235 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 758793019236 dimer interface [polypeptide binding]; other site 758793019237 active site 758793019238 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 758793019239 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 758793019240 ligand binding site [chemical binding]; other site 758793019241 flexible hinge region; other site 758793019242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 758793019243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 758793019244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 758793019245 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 758793019246 dimerization interface [polypeptide binding]; other site 758793019247 putative DNA binding site [nucleotide binding]; other site 758793019248 putative Zn2+ binding site [ion binding]; other site 758793019249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 758793019250 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 758793019251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793019252 putative substrate translocation pore; other site 758793019253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 758793019254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 758793019255 NAD(P) binding site [chemical binding]; other site 758793019256 active site 758793019257 Isochorismatase family; Region: Isochorismatase; pfam00857 758793019258 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 758793019259 catalytic triad [active] 758793019260 conserved cis-peptide bond; other site 758793019261 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 758793019262 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 758793019263 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 758793019264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793019265 putative substrate translocation pore; other site 758793019266 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 758793019267 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 758793019268 putative NAD(P) binding site [chemical binding]; other site 758793019269 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 758793019270 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 758793019271 Transcriptional regulator [Transcription]; Region: LysR; COG0583 758793019272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 758793019273 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 758793019274 dimerization interface [polypeptide binding]; other site 758793019275 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 758793019276 amidase; Provisional; Region: PRK07056 758793019277 Amidase; Region: Amidase; cl11426 758793019278 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 758793019279 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 758793019280 dimerization interface [polypeptide binding]; other site 758793019281 ligand binding site [chemical binding]; other site 758793019282 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 758793019283 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 758793019284 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 758793019285 active site 758793019286 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 758793019287 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 758793019288 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 758793019289 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 758793019290 NADP binding site [chemical binding]; other site 758793019291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 758793019292 D-galactonate transporter; Region: 2A0114; TIGR00893 758793019293 putative substrate translocation pore; other site 758793019294 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 758793019295 Catalytic domain of Protein Kinases; Region: PKc; cd00180 758793019296 substrate binding site [chemical binding]; other site 758793019297 activation loop (A-loop); other site 758793019298 AAA ATPase domain; Region: AAA_16; pfam13191 758793019299 Predicted ATPase [General function prediction only]; Region: COG3899 758793019300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 758793019301 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 758793019302 PAS domain S-box; Region: sensory_box; TIGR00229 758793019303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 758793019304 putative active site [active] 758793019305 heme pocket [chemical binding]; other site 758793019306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 758793019307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 758793019308 dimer interface [polypeptide binding]; other site 758793019309 phosphorylation site [posttranslational modification] 758793019310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 758793019311 ATP binding site [chemical binding]; other site 758793019312 Mg2+ binding site [ion binding]; other site 758793019313 G-X-G motif; other site