-- dump date   	20140619_020018
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1097668000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1097668000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1097668000003	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1097668000004	DnaA box-binding interface [nucleotide binding]; other site
1097668000005	DNA polymerase III subunit beta; Validated; Region: PRK05643
1097668000006	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1097668000007	putative DNA binding surface [nucleotide binding]; other site
1097668000008	dimer interface [polypeptide binding]; other site
1097668000009	beta-clamp/clamp loader binding surface; other site
1097668000010	beta-clamp/translesion DNA polymerase binding surface; other site
1097668000011	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1097668000012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668000013	ATP binding site [chemical binding]; other site
1097668000014	Mg2+ binding site [ion binding]; other site
1097668000015	G-X-G motif; other site
1097668000016	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1097668000017	anchoring element; other site
1097668000018	dimer interface [polypeptide binding]; other site
1097668000019	ATP binding site [chemical binding]; other site
1097668000020	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1097668000021	active site
1097668000022	putative metal-binding site [ion binding]; other site
1097668000023	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1097668000024	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668000025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668000026	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1097668000027	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1097668000028	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668000029	catalytic loop [active]
1097668000030	iron binding site [ion binding]; other site
1097668000031	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1097668000032	FAD binding pocket [chemical binding]; other site
1097668000033	conserved FAD binding motif [chemical binding]; other site
1097668000034	phosphate binding motif [ion binding]; other site
1097668000035	beta-alpha-beta structure motif; other site
1097668000036	NAD binding pocket [chemical binding]; other site
1097668000037	hybrid cluster protein; Provisional; Region: PRK05290
1097668000038	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1097668000039	ACS interaction site; other site
1097668000040	CODH interaction site; other site
1097668000041	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
1097668000042	hybrid metal cluster; other site
1097668000043	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1097668000044	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097668000045	ATP binding site [chemical binding]; other site
1097668000046	Mg++ binding site [ion binding]; other site
1097668000047	motif III; other site
1097668000048	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668000049	nucleotide binding region [chemical binding]; other site
1097668000050	ATP-binding site [chemical binding]; other site
1097668000051	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1097668000052	putative RNA binding site [nucleotide binding]; other site
1097668000053	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668000054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668000055	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668000056	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097668000057	CoenzymeA binding site [chemical binding]; other site
1097668000058	subunit interaction site [polypeptide binding]; other site
1097668000059	PHB binding site; other site
1097668000060	Patatin-like phospholipase; Region: Patatin; pfam01734
1097668000061	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1097668000062	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
1097668000063	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1097668000064	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1097668000065	dimerization interface [polypeptide binding]; other site
1097668000066	NAD binding site [chemical binding]; other site
1097668000067	ligand binding site [chemical binding]; other site
1097668000068	catalytic site [active]
1097668000069	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1097668000070	active site
1097668000071	substrate-binding site [chemical binding]; other site
1097668000072	metal-binding site [ion binding]
1097668000073	GTP binding site [chemical binding]; other site
1097668000074	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668000075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668000076	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668000077	putative effector binding pocket; other site
1097668000078	dimerization interface [polypeptide binding]; other site
1097668000079	DNA topoisomerase III; Validated; Region: PRK08173
1097668000080	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1097668000081	active site
1097668000082	putative interdomain interaction site [polypeptide binding]; other site
1097668000083	putative metal-binding site [ion binding]; other site
1097668000084	putative nucleotide binding site [chemical binding]; other site
1097668000085	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1097668000086	domain I; other site
1097668000087	DNA binding groove [nucleotide binding]
1097668000088	phosphate binding site [ion binding]; other site
1097668000089	domain II; other site
1097668000090	domain III; other site
1097668000091	nucleotide binding site [chemical binding]; other site
1097668000092	catalytic site [active]
1097668000093	domain IV; other site
1097668000094	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1097668000095	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1097668000096	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1097668000097	catalytic residues [active]
1097668000098	DNA protecting protein DprA; Region: dprA; TIGR00732
1097668000099	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1097668000100	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1097668000101	active site
1097668000102	catalytic residues [active]
1097668000103	metal binding site [ion binding]; metal-binding site
1097668000104	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1097668000105	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1097668000106	putative active site [active]
1097668000107	substrate binding site [chemical binding]; other site
1097668000108	putative cosubstrate binding site; other site
1097668000109	catalytic site [active]
1097668000110	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1097668000111	substrate binding site [chemical binding]; other site
1097668000112	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668000113	M48 family peptidase; Provisional; Region: PRK03001
1097668000114	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1097668000115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668000116	S-adenosylmethionine binding site [chemical binding]; other site
1097668000117	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
1097668000118	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1097668000119	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668000120	dimerization interface [polypeptide binding]; other site
1097668000121	PAS domain; Region: PAS; smart00091
1097668000122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668000123	dimer interface [polypeptide binding]; other site
1097668000124	phosphorylation site [posttranslational modification]
1097668000125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668000126	ATP binding site [chemical binding]; other site
1097668000127	Mg2+ binding site [ion binding]; other site
1097668000128	G-X-G motif; other site
1097668000129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000130	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668000131	active site
1097668000132	phosphorylation site [posttranslational modification]
1097668000133	intermolecular recognition site; other site
1097668000134	dimerization interface [polypeptide binding]; other site
1097668000135	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1097668000136	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
1097668000137	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1097668000138	Ligand Binding Site [chemical binding]; other site
1097668000139	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1097668000140	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1097668000141	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1097668000142	active site
1097668000143	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1097668000144	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1097668000145	Sel1-like repeats; Region: SEL1; smart00671
1097668000146	Sel1-like repeats; Region: SEL1; smart00671
1097668000147	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1097668000148	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1097668000149	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1097668000150	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1097668000151	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1097668000152	rod shape-determining protein MreC; Provisional; Region: PRK13922
1097668000153	rod shape-determining protein MreC; Region: MreC; pfam04085
1097668000154	rod shape-determining protein MreB; Provisional; Region: PRK13927
1097668000155	MreB and similar proteins; Region: MreB_like; cd10225
1097668000156	nucleotide binding site [chemical binding]; other site
1097668000157	Mg binding site [ion binding]; other site
1097668000158	putative protofilament interaction site [polypeptide binding]; other site
1097668000159	RodZ interaction site [polypeptide binding]; other site
1097668000160	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1097668000161	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1097668000162	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1097668000163	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1097668000164	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1097668000165	GatB domain; Region: GatB_Yqey; smart00845
1097668000166	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1097668000167	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1097668000168	putative active site [active]
1097668000169	putative catalytic site [active]
1097668000170	putative DNA binding site [nucleotide binding]; other site
1097668000171	putative phosphate binding site [ion binding]; other site
1097668000172	metal binding site A [ion binding]; metal-binding site
1097668000173	putative AP binding site [nucleotide binding]; other site
1097668000174	putative metal binding site B [ion binding]; other site
1097668000175	Peptidase family M48; Region: Peptidase_M48; cl12018
1097668000176	muropeptide transporter; Validated; Region: ampG; cl17669
1097668000177	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1097668000178	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668000179	S-adenosylmethionine binding site [chemical binding]; other site
1097668000180	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1097668000181	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1097668000182	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1097668000183	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
1097668000184	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
1097668000185	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668000186	motif II; other site
1097668000187	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1097668000188	feedback inhibition sensing region; other site
1097668000189	homohexameric interface [polypeptide binding]; other site
1097668000190	nucleotide binding site [chemical binding]; other site
1097668000191	N-acetyl-L-glutamate binding site [chemical binding]; other site
1097668000192	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668000193	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1097668000194	dimer interface [polypeptide binding]; other site
1097668000195	phosphorylation site [posttranslational modification]
1097668000196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668000197	ATP binding site [chemical binding]; other site
1097668000198	Mg2+ binding site [ion binding]; other site
1097668000199	G-X-G motif; other site
1097668000200	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
1097668000201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000202	active site
1097668000203	phosphorylation site [posttranslational modification]
1097668000204	intermolecular recognition site; other site
1097668000205	dimerization interface [polypeptide binding]; other site
1097668000206	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668000207	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1097668000208	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668000209	dimer interface [polypeptide binding]; other site
1097668000210	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1097668000211	putative CheW interface [polypeptide binding]; other site
1097668000212	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
1097668000213	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1097668000214	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1097668000215	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668000216	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
1097668000217	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1097668000218	dimer interface [polypeptide binding]; other site
1097668000219	PYR/PP interface [polypeptide binding]; other site
1097668000220	TPP binding site [chemical binding]; other site
1097668000221	substrate binding site [chemical binding]; other site
1097668000222	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1097668000223	TPP-binding site [chemical binding]; other site
1097668000224	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
1097668000225	glutathionine S-transferase; Provisional; Region: PRK10542
1097668000226	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1097668000227	putative C-terminal domain interface [polypeptide binding]; other site
1097668000228	putative GSH binding site (G-site) [chemical binding]; other site
1097668000229	putative dimer interface [polypeptide binding]; other site
1097668000230	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
1097668000231	dimer interface [polypeptide binding]; other site
1097668000232	N-terminal domain interface [polypeptide binding]; other site
1097668000233	putative substrate binding pocket (H-site) [chemical binding]; other site
1097668000234	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1097668000235	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097668000236	putative substrate binding site [chemical binding]; other site
1097668000237	putative ATP binding site [chemical binding]; other site
1097668000238	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1097668000239	dimerization interface [polypeptide binding]; other site
1097668000240	putative active cleft [active]
1097668000241	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668000242	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668000243	DNA binding site [nucleotide binding]
1097668000244	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097668000245	ligand binding site [chemical binding]; other site
1097668000246	dimerization interface [polypeptide binding]; other site
1097668000247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668000248	S-adenosylmethionine binding site [chemical binding]; other site
1097668000249	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1097668000250	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668000251	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1097668000252	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1097668000253	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668000254	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668000255	trimer interface [polypeptide binding]; other site
1097668000256	eyelet of channel; other site
1097668000257	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1097668000258	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1097668000259	FMN binding site [chemical binding]; other site
1097668000260	substrate binding site [chemical binding]; other site
1097668000261	putative catalytic residue [active]
1097668000262	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1097668000263	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668000264	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1097668000265	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1097668000266	active site
1097668000267	catalytic site [active]
1097668000268	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
1097668000269	putative deacylase active site [active]
1097668000270	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1097668000271	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1097668000272	active site
1097668000273	catalytic residues [active]
1097668000274	metal binding site [ion binding]; metal-binding site
1097668000275	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
1097668000276	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1097668000277	putative ligand binding site [chemical binding]; other site
1097668000278	NAD binding site [chemical binding]; other site
1097668000279	dimerization interface [polypeptide binding]; other site
1097668000280	catalytic site [active]
1097668000281	biotin synthase; Region: bioB; TIGR00433
1097668000282	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668000283	FeS/SAM binding site; other site
1097668000284	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1097668000285	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1097668000286	AAA domain; Region: AAA_26; pfam13500
1097668000287	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1097668000288	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1097668000289	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668000290	catalytic residue [active]
1097668000291	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
1097668000292	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668000293	inhibitor-cofactor binding pocket; inhibition site
1097668000294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668000295	catalytic residue [active]
1097668000296	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1097668000297	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668000298	hypothetical protein; Provisional; Region: PRK01842
1097668000299	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668000300	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1097668000301	putative C-terminal domain interface [polypeptide binding]; other site
1097668000302	putative GSH binding site (G-site) [chemical binding]; other site
1097668000303	putative dimer interface [polypeptide binding]; other site
1097668000304	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668000305	N-terminal domain interface [polypeptide binding]; other site
1097668000306	dimer interface [polypeptide binding]; other site
1097668000307	substrate binding pocket (H-site) [chemical binding]; other site
1097668000308	short chain dehydrogenase; Provisional; Region: PRK06953
1097668000309	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1097668000310	NAD(P) binding site [chemical binding]; other site
1097668000311	active site
1097668000312	hypothetical protein; Provisional; Region: PRK09126
1097668000313	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668000314	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1097668000315	oligomeric interface; other site
1097668000316	putative active site [active]
1097668000317	homodimer interface [polypeptide binding]; other site
1097668000318	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1097668000319	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668000320	dimer interface [polypeptide binding]; other site
1097668000321	active site
1097668000322	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1097668000323	active site clefts [active]
1097668000324	zinc binding site [ion binding]; other site
1097668000325	dimer interface [polypeptide binding]; other site
1097668000326	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
1097668000327	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1097668000328	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1097668000329	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097668000330	DNA binding residues [nucleotide binding]
1097668000331	putative dimer interface [polypeptide binding]; other site
1097668000332	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1097668000333	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668000334	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1097668000335	peptide binding site [polypeptide binding]; other site
1097668000336	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
1097668000337	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1097668000338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668000339	binding surface
1097668000340	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1097668000341	TPR motif; other site
1097668000342	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
1097668000343	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668000344	TPR motif; other site
1097668000345	binding surface
1097668000346	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1097668000347	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097668000348	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097668000349	WbqC-like protein family; Region: WbqC; pfam08889
1097668000350	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1097668000351	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1097668000352	inhibitor-cofactor binding pocket; inhibition site
1097668000353	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668000354	catalytic residue [active]
1097668000355	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1097668000356	flagellin; Reviewed; Region: PRK08869
1097668000357	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1097668000358	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1097668000359	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668000360	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668000361	active site
1097668000362	catalytic tetrad [active]
1097668000363	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1097668000364	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1097668000365	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1097668000366	putative hydrolase; Provisional; Region: PRK10976
1097668000367	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668000368	active site
1097668000369	motif I; other site
1097668000370	motif II; other site
1097668000371	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1097668000372	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1097668000373	amphipathic channel; other site
1097668000374	Asn-Pro-Ala signature motifs; other site
1097668000375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668000376	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1097668000377	putative ADP-binding pocket [chemical binding]; other site
1097668000378	Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012
1097668000379	transcriptional activator FlhC; Provisional; Region: PRK12722
1097668000380	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1097668000381	flagellar motor protein MotA; Validated; Region: PRK09110
1097668000382	flagellar motor protein MotB; Validated; Region: motB; PRK09041
1097668000383	Protein of unknown function, DUF484; Region: DUF484; cl17449
1097668000384	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668000385	ligand binding site [chemical binding]; other site
1097668000386	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668000387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000388	active site
1097668000389	phosphorylation site [posttranslational modification]
1097668000390	intermolecular recognition site; other site
1097668000391	dimerization interface [polypeptide binding]; other site
1097668000392	chemotaxis protein CheA; Provisional; Region: PRK10547
1097668000393	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1097668000394	putative binding surface; other site
1097668000395	active site
1097668000396	CheY binding; Region: CheY-binding; pfam09078
1097668000397	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1097668000398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668000399	ATP binding site [chemical binding]; other site
1097668000400	Mg2+ binding site [ion binding]; other site
1097668000401	G-X-G motif; other site
1097668000402	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1097668000403	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1097668000404	putative CheA interaction surface; other site
1097668000405	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1097668000406	dimer interface [polypeptide binding]; other site
1097668000407	ligand binding site [chemical binding]; other site
1097668000408	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668000409	dimerization interface [polypeptide binding]; other site
1097668000410	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1097668000411	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668000412	dimer interface [polypeptide binding]; other site
1097668000413	putative CheW interface [polypeptide binding]; other site
1097668000414	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1097668000415	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
1097668000416	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1097668000417	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489
1097668000418	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1097668000419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000420	active site
1097668000421	phosphorylation site [posttranslational modification]
1097668000422	intermolecular recognition site; other site
1097668000423	dimerization interface [polypeptide binding]; other site
1097668000424	CheB methylesterase; Region: CheB_methylest; pfam01339
1097668000425	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1097668000426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000427	active site
1097668000428	phosphorylation site [posttranslational modification]
1097668000429	intermolecular recognition site; other site
1097668000430	dimerization interface [polypeptide binding]; other site
1097668000431	chemotaxis regulator CheZ; Provisional; Region: PRK11166
1097668000432	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
1097668000433	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
1097668000434	short chain dehydrogenase; Provisional; Region: PRK07024
1097668000435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668000436	NAD(P) binding site [chemical binding]; other site
1097668000437	active site
1097668000438	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1097668000439	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1097668000440	catalytic residues [active]
1097668000441	hinge region; other site
1097668000442	alpha helical domain; other site
1097668000443	Sporulation related domain; Region: SPOR; pfam05036
1097668000444	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1097668000445	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1097668000446	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1097668000447	active site
1097668000448	HIGH motif; other site
1097668000449	KMSK motif region; other site
1097668000450	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1097668000451	tRNA binding surface [nucleotide binding]; other site
1097668000452	anticodon binding site; other site
1097668000453	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
1097668000454	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1097668000455	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1097668000456	substrate binding pocket [chemical binding]; other site
1097668000457	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1097668000458	B12 binding site [chemical binding]; other site
1097668000459	cobalt ligand [ion binding]; other site
1097668000460	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1097668000461	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
1097668000462	Predicted ATPase [General function prediction only]; Region: COG4637
1097668000463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668000464	Walker A/P-loop; other site
1097668000465	ATP binding site [chemical binding]; other site
1097668000466	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1097668000467	ABC transporter signature motif; other site
1097668000468	Walker B; other site
1097668000469	D-loop; other site
1097668000470	H-loop/switch region; other site
1097668000471	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1097668000472	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1097668000473	Protein of unknown function (DUF3567); Region: DUF3567; pfam12091
1097668000474	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1097668000475	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1097668000476	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668000477	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668000478	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668000479	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668000480	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668000481	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1097668000482	putative ligand binding site [chemical binding]; other site
1097668000483	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1097668000484	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668000485	substrate binding site [chemical binding]; other site
1097668000486	oxyanion hole (OAH) forming residues; other site
1097668000487	trimer interface [polypeptide binding]; other site
1097668000488	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1097668000489	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1097668000490	DNA binding residues [nucleotide binding]
1097668000491	B12 binding domain; Region: B12-binding_2; pfam02607
1097668000492	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
1097668000493	B12 binding site [chemical binding]; other site
1097668000494	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1097668000495	dinuclear metal binding motif [ion binding]; other site
1097668000496	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1097668000497	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1097668000498	active site
1097668000499	HIGH motif; other site
1097668000500	nucleotide binding site [chemical binding]; other site
1097668000501	pantothenate kinase; Reviewed; Region: PRK13328
1097668000502	biotin--protein ligase; Provisional; Region: PRK06955
1097668000503	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1097668000504	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1097668000505	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668000506	non-specific DNA binding site [nucleotide binding]; other site
1097668000507	salt bridge; other site
1097668000508	sequence-specific DNA binding site [nucleotide binding]; other site
1097668000509	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
1097668000510	Permease; Region: Permease; pfam02405
1097668000511	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1097668000512	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1097668000513	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1097668000514	Walker A/P-loop; other site
1097668000515	ATP binding site [chemical binding]; other site
1097668000516	Q-loop/lid; other site
1097668000517	ABC transporter signature motif; other site
1097668000518	Walker B; other site
1097668000519	D-loop; other site
1097668000520	H-loop/switch region; other site
1097668000521	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1097668000522	mce related protein; Region: MCE; pfam02470
1097668000523	Protein of unknown function (DUF330); Region: DUF330; cl01135
1097668000524	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1097668000525	dimer interface [polypeptide binding]; other site
1097668000526	[2Fe-2S] cluster binding site [ion binding]; other site
1097668000527	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1097668000528	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1097668000529	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1097668000530	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1097668000531	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1097668000532	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1097668000533	homodimer interface [polypeptide binding]; other site
1097668000534	substrate-cofactor binding pocket; other site
1097668000535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668000536	catalytic residue [active]
1097668000537	Protein of unknown function (DUF493); Region: DUF493; cl01102
1097668000538	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668000539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668000540	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668000541	dimerization interface [polypeptide binding]; other site
1097668000542	substrate binding pocket [chemical binding]; other site
1097668000543	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
1097668000544	lipoate-protein ligase B; Provisional; Region: PRK14343
1097668000545	lipoyl synthase; Provisional; Region: PRK05481
1097668000546	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668000547	FeS/SAM binding site; other site
1097668000548	Virulence protein [General function prediction only]; Region: COG3943
1097668000549	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
1097668000550	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1097668000551	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097668000552	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1097668000553	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668000554	dimer interface [polypeptide binding]; other site
1097668000555	phosphorylation site [posttranslational modification]
1097668000556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668000557	ATP binding site [chemical binding]; other site
1097668000558	Mg2+ binding site [ion binding]; other site
1097668000559	G-X-G motif; other site
1097668000560	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1097668000561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000562	active site
1097668000563	phosphorylation site [posttranslational modification]
1097668000564	intermolecular recognition site; other site
1097668000565	dimerization interface [polypeptide binding]; other site
1097668000566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668000567	Walker A motif; other site
1097668000568	ATP binding site [chemical binding]; other site
1097668000569	Walker B motif; other site
1097668000570	arginine finger; other site
1097668000571	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668000572	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1097668000573	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668000574	catalytic residues [active]
1097668000575	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1097668000576	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1097668000577	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1097668000578	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668000579	active site
1097668000580	DNA binding site [nucleotide binding]
1097668000581	Int/Topo IB signature motif; other site
1097668000582	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668000583	active site
1097668000584	catalytic residues [active]
1097668000585	DNA binding site [nucleotide binding]
1097668000586	Int/Topo IB signature motif; other site
1097668000587	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1097668000588	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1097668000589	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
1097668000590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668000591	Walker A motif; other site
1097668000592	ATP binding site [chemical binding]; other site
1097668000593	Walker B motif; other site
1097668000594	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1097668000595	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1097668000596	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668000597	active site
1097668000598	DNA binding site [nucleotide binding]
1097668000599	Int/Topo IB signature motif; other site
1097668000600	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1097668000601	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
1097668000602	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
1097668000603	Int/Topo IB signature motif; other site
1097668000604	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1097668000605	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1097668000606	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1097668000607	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668000608	S-adenosylmethionine binding site [chemical binding]; other site
1097668000609	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1097668000610	AAA domain; Region: AAA_13; pfam13166
1097668000611	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1097668000612	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1097668000613	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1097668000614	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1097668000615	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1097668000616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668000617	ATP binding site [chemical binding]; other site
1097668000618	putative Mg++ binding site [ion binding]; other site
1097668000619	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1097668000620	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668000621	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668000622	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668000623	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668000624	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668000625	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1097668000626	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668000627	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668000628	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
1097668000629	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1097668000630	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1097668000631	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1097668000632	Membrane fusogenic activity; Region: BMFP; pfam04380
1097668000633	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1097668000634	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1097668000635	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1097668000636	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
1097668000637	Glutamate-cysteine ligase; Region: GshA; pfam08886
1097668000638	glutathione synthetase; Provisional; Region: PRK05246
1097668000639	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1097668000640	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1097668000641	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1097668000642	active pocket/dimerization site; other site
1097668000643	active site
1097668000644	phosphorylation site [posttranslational modification]
1097668000645	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1097668000646	dimerization domain swap beta strand [polypeptide binding]; other site
1097668000647	regulatory protein interface [polypeptide binding]; other site
1097668000648	active site
1097668000649	regulatory phosphorylation site [posttranslational modification]; other site
1097668000650	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1097668000651	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1097668000652	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1097668000653	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1097668000654	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1097668000655	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1097668000656	ATP binding site [chemical binding]; other site
1097668000657	substrate interface [chemical binding]; other site
1097668000658	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1097668000659	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1097668000660	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1097668000661	protein binding site [polypeptide binding]; other site
1097668000662	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1097668000663	Catalytic dyad [active]
1097668000664	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097668000665	catalytic core [active]
1097668000666	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097668000667	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1097668000668	active site residue [active]
1097668000669	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1097668000670	GSH binding site [chemical binding]; other site
1097668000671	catalytic residues [active]
1097668000672	preprotein translocase subunit SecB; Validated; Region: PRK05751
1097668000673	SecA binding site; other site
1097668000674	Preprotein binding site; other site
1097668000675	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1097668000676	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1097668000677	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1097668000678	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1097668000679	putative ADP-ribose binding site [chemical binding]; other site
1097668000680	putative active site [active]
1097668000681	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1097668000682	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1097668000683	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668000684	active site
1097668000685	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1097668000686	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668000687	S-adenosylmethionine binding site [chemical binding]; other site
1097668000688	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
1097668000689	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1097668000690	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
1097668000691	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1097668000692	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668000693	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1097668000694	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668000695	ligand binding site [chemical binding]; other site
1097668000696	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1097668000697	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
1097668000698	Subunit I/III interface [polypeptide binding]; other site
1097668000699	D-pathway; other site
1097668000700	Subunit I/VIIc interface [polypeptide binding]; other site
1097668000701	Subunit I/IV interface [polypeptide binding]; other site
1097668000702	Subunit I/II interface [polypeptide binding]; other site
1097668000703	Low-spin heme (heme a) binding site [chemical binding]; other site
1097668000704	Subunit I/VIIa interface [polypeptide binding]; other site
1097668000705	Subunit I/VIa interface [polypeptide binding]; other site
1097668000706	Dimer interface; other site
1097668000707	Putative water exit pathway; other site
1097668000708	Binuclear center (heme a3/CuB) [ion binding]; other site
1097668000709	K-pathway; other site
1097668000710	Subunit I/Vb interface [polypeptide binding]; other site
1097668000711	Putative proton exit pathway; other site
1097668000712	Subunit I/VIb interface; other site
1097668000713	Subunit I/VIc interface [polypeptide binding]; other site
1097668000714	Electron transfer pathway; other site
1097668000715	Subunit I/VIIIb interface [polypeptide binding]; other site
1097668000716	Subunit I/VIIb interface [polypeptide binding]; other site
1097668000717	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
1097668000718	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
1097668000719	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
1097668000720	Subunit III/VIIa interface [polypeptide binding]; other site
1097668000721	Phospholipid binding site [chemical binding]; other site
1097668000722	Subunit I/III interface [polypeptide binding]; other site
1097668000723	Subunit III/VIb interface [polypeptide binding]; other site
1097668000724	Subunit III/VIa interface; other site
1097668000725	Subunit III/Vb interface [polypeptide binding]; other site
1097668000726	Protein of unknown function (DUF2909); Region: DUF2909; pfam11137
1097668000727	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1097668000728	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1097668000729	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1097668000730	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1097668000731	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1097668000732	UbiA prenyltransferase family; Region: UbiA; pfam01040
1097668000733	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1097668000734	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1097668000735	Cu(I) binding site [ion binding]; other site
1097668000736	YCII-related domain; Region: YCII; cl00999
1097668000737	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1097668000738	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1097668000739	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668000740	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668000741	putative DNA binding site [nucleotide binding]; other site
1097668000742	putative Zn2+ binding site [ion binding]; other site
1097668000743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668000744	Coenzyme A binding pocket [chemical binding]; other site
1097668000745	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1097668000746	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1097668000747	active site
1097668000748	dimer interface [polypeptide binding]; other site
1097668000749	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1097668000750	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1097668000751	dimer interface [polypeptide binding]; other site
1097668000752	active site
1097668000753	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1097668000754	dimer interface [polypeptide binding]; other site
1097668000755	active site
1097668000756	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1097668000757	HPr interaction site; other site
1097668000758	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1097668000759	active site
1097668000760	phosphorylation site [posttranslational modification]
1097668000761	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1097668000762	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1097668000763	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1097668000764	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1097668000765	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1097668000766	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1097668000767	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1097668000768	active site turn [active]
1097668000769	phosphorylation site [posttranslational modification]
1097668000770	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1097668000771	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668000772	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668000773	DNA binding residues [nucleotide binding]
1097668000774	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
1097668000775	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1097668000776	SnoaL-like domain; Region: SnoaL_3; pfam13474
1097668000777	2-isopropylmalate synthase; Validated; Region: PRK03739
1097668000778	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1097668000779	active site
1097668000780	catalytic residues [active]
1097668000781	metal binding site [ion binding]; metal-binding site
1097668000782	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1097668000783	glycosyl transferase family protein; Provisional; Region: PRK08136
1097668000784	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1097668000785	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668000786	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668000787	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1097668000788	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1097668000789	C-terminal domain interface [polypeptide binding]; other site
1097668000790	GSH binding site (G-site) [chemical binding]; other site
1097668000791	putative dimer interface [polypeptide binding]; other site
1097668000792	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1097668000793	dimer interface [polypeptide binding]; other site
1097668000794	N-terminal domain interface [polypeptide binding]; other site
1097668000795	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1097668000796	Lysine efflux permease [General function prediction only]; Region: COG1279
1097668000797	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1097668000798	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1097668000799	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1097668000800	P loop; other site
1097668000801	GTP binding site [chemical binding]; other site
1097668000802	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1097668000803	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668000804	S-adenosylmethionine binding site [chemical binding]; other site
1097668000805	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1097668000806	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1097668000807	active site
1097668000808	(T/H)XGH motif; other site
1097668000809	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1097668000810	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1097668000811	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668000812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668000813	homodimer interface [polypeptide binding]; other site
1097668000814	catalytic residue [active]
1097668000815	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1097668000816	putative active site [active]
1097668000817	catalytic residue [active]
1097668000818	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1097668000819	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1097668000820	5S rRNA interface [nucleotide binding]; other site
1097668000821	CTC domain interface [polypeptide binding]; other site
1097668000822	L16 interface [polypeptide binding]; other site
1097668000823	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1097668000824	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1097668000825	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668000826	active site
1097668000827	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1097668000828	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1097668000829	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1097668000830	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1097668000831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668000832	TPR motif; other site
1097668000833	binding surface
1097668000834	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668000835	binding surface
1097668000836	TPR motif; other site
1097668000837	TPR repeat; Region: TPR_11; pfam13414
1097668000838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668000839	binding surface
1097668000840	TPR motif; other site
1097668000841	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1097668000842	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1097668000843	DNA binding site [nucleotide binding]
1097668000844	catalytic residue [active]
1097668000845	H2TH interface [polypeptide binding]; other site
1097668000846	putative catalytic residues [active]
1097668000847	turnover-facilitating residue; other site
1097668000848	intercalation triad [nucleotide binding]; other site
1097668000849	8OG recognition residue [nucleotide binding]; other site
1097668000850	putative reading head residues; other site
1097668000851	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1097668000852	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1097668000853	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1097668000854	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1097668000855	minor groove reading motif; other site
1097668000856	helix-hairpin-helix signature motif; other site
1097668000857	substrate binding pocket [chemical binding]; other site
1097668000858	active site
1097668000859	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1097668000860	DNA binding and oxoG recognition site [nucleotide binding]
1097668000861	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1097668000862	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1097668000863	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1097668000864	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1097668000865	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1097668000866	Hpr binding site; other site
1097668000867	active site
1097668000868	homohexamer subunit interaction site [polypeptide binding]; other site
1097668000869	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1097668000870	active site
1097668000871	phosphorylation site [posttranslational modification]
1097668000872	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1097668000873	30S subunit binding site; other site
1097668000874	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1097668000875	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1097668000876	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1097668000877	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1097668000878	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1097668000879	Walker A/P-loop; other site
1097668000880	ATP binding site [chemical binding]; other site
1097668000881	Q-loop/lid; other site
1097668000882	ABC transporter signature motif; other site
1097668000883	Walker B; other site
1097668000884	D-loop; other site
1097668000885	H-loop/switch region; other site
1097668000886	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1097668000887	OstA-like protein; Region: OstA; pfam03968
1097668000888	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1097668000889	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
1097668000890	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
1097668000891	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1097668000892	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1097668000893	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1097668000894	putative active site [active]
1097668000895	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1097668000896	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1097668000897	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1097668000898	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1097668000899	TrkA-N domain; Region: TrkA_N; pfam02254
1097668000900	TrkA-C domain; Region: TrkA_C; pfam02080
1097668000901	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668000902	active site
1097668000903	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668000904	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676
1097668000905	nudix motif; other site
1097668000906	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1097668000907	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1097668000908	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1097668000909	putative active site [active]
1097668000910	putative substrate binding site [chemical binding]; other site
1097668000911	putative cosubstrate binding site; other site
1097668000912	catalytic site [active]
1097668000913	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1097668000914	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1097668000915	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097668000916	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097668000917	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1097668000918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668000919	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668000920	putative substrate translocation pore; other site
1097668000921	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1097668000922	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1097668000923	dimer interface [polypeptide binding]; other site
1097668000924	ssDNA binding site [nucleotide binding]; other site
1097668000925	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1097668000926	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668000927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000928	active site
1097668000929	phosphorylation site [posttranslational modification]
1097668000930	intermolecular recognition site; other site
1097668000931	dimerization interface [polypeptide binding]; other site
1097668000932	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668000933	DNA binding residues [nucleotide binding]
1097668000934	dimerization interface [polypeptide binding]; other site
1097668000935	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668000936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000937	active site
1097668000938	phosphorylation site [posttranslational modification]
1097668000939	intermolecular recognition site; other site
1097668000940	dimerization interface [polypeptide binding]; other site
1097668000941	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668000942	DNA binding residues [nucleotide binding]
1097668000943	dimerization interface [polypeptide binding]; other site
1097668000944	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668000945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000946	active site
1097668000947	phosphorylation site [posttranslational modification]
1097668000948	intermolecular recognition site; other site
1097668000949	dimerization interface [polypeptide binding]; other site
1097668000950	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668000951	DNA binding residues [nucleotide binding]
1097668000952	dimerization interface [polypeptide binding]; other site
1097668000953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668000954	PAS domain; Region: PAS_9; pfam13426
1097668000955	putative active site [active]
1097668000956	heme pocket [chemical binding]; other site
1097668000957	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668000958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668000959	dimer interface [polypeptide binding]; other site
1097668000960	phosphorylation site [posttranslational modification]
1097668000961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668000962	ATP binding site [chemical binding]; other site
1097668000963	Mg2+ binding site [ion binding]; other site
1097668000964	G-X-G motif; other site
1097668000965	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668000966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668000967	active site
1097668000968	phosphorylation site [posttranslational modification]
1097668000969	intermolecular recognition site; other site
1097668000970	dimerization interface [polypeptide binding]; other site
1097668000971	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668000972	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668000973	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668000974	putative effector binding pocket; other site
1097668000975	dimerization interface [polypeptide binding]; other site
1097668000976	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668000977	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668000978	trimer interface [polypeptide binding]; other site
1097668000979	eyelet of channel; other site
1097668000980	CHRD domain; Region: CHRD; pfam07452
1097668000981	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668000982	EcsC protein family; Region: EcsC; pfam12787
1097668000983	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668000984	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668000985	putative substrate translocation pore; other site
1097668000986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668000987	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668000988	MarR family; Region: MarR; pfam01047
1097668000989	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1097668000990	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
1097668000991	dimer interface [polypeptide binding]; other site
1097668000992	active site
1097668000993	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668000994	substrate binding site [chemical binding]; other site
1097668000995	catalytic residue [active]
1097668000996	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097668000997	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097668000998	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097668000999	putative active site [active]
1097668001000	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1097668001001	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1097668001002	active site
1097668001003	putative substrate binding pocket [chemical binding]; other site
1097668001004	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1097668001005	homotrimer interaction site [polypeptide binding]; other site
1097668001006	putative active site [active]
1097668001007	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
1097668001008	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668001009	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097668001010	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1097668001011	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1097668001012	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1097668001013	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
1097668001014	threonine dehydratase; Reviewed; Region: PRK09224
1097668001015	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1097668001016	tetramer interface [polypeptide binding]; other site
1097668001017	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668001018	catalytic residue [active]
1097668001019	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1097668001020	putative Ile/Val binding site [chemical binding]; other site
1097668001021	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1097668001022	putative Ile/Val binding site [chemical binding]; other site
1097668001023	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
1097668001024	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668001025	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668001026	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668001027	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
1097668001028	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1097668001029	Cysteine-rich domain; Region: CCG; pfam02754
1097668001030	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
1097668001031	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1097668001032	nucleotide binding site/active site [active]
1097668001033	HIT family signature motif; other site
1097668001034	catalytic residue [active]
1097668001035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
1097668001036	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1097668001037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668001038	S-adenosylmethionine binding site [chemical binding]; other site
1097668001039	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
1097668001040	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1097668001041	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1097668001042	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1097668001043	Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724
1097668001044	S-adenosylmethionine binding site [chemical binding]; other site
1097668001045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668001046	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1097668001047	Uncharacterized conserved protein [Function unknown]; Region: COG2928
1097668001048	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1097668001049	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1097668001050	dimer interface [polypeptide binding]; other site
1097668001051	anticodon binding site; other site
1097668001052	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1097668001053	homodimer interface [polypeptide binding]; other site
1097668001054	motif 1; other site
1097668001055	active site
1097668001056	motif 2; other site
1097668001057	GAD domain; Region: GAD; pfam02938
1097668001058	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1097668001059	motif 3; other site
1097668001060	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
1097668001061	nudix motif; other site
1097668001062	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1097668001063	PLD-like domain; Region: PLDc_2; pfam13091
1097668001064	putative active site [active]
1097668001065	catalytic site [active]
1097668001066	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1097668001067	PLD-like domain; Region: PLDc_2; pfam13091
1097668001068	putative active site [active]
1097668001069	catalytic site [active]
1097668001070	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668001071	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668001072	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1097668001073	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1097668001074	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668001075	active site
1097668001076	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1097668001077	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1097668001078	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668001079	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668001080	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668001081	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668001082	substrate binding site [chemical binding]; other site
1097668001083	oxyanion hole (OAH) forming residues; other site
1097668001084	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
1097668001085	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668001086	dimer interface [polypeptide binding]; other site
1097668001087	active site
1097668001088	enoyl-CoA hydratase; Provisional; Region: PRK06688
1097668001089	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668001090	substrate binding site [chemical binding]; other site
1097668001091	oxyanion hole (OAH) forming residues; other site
1097668001092	trimer interface [polypeptide binding]; other site
1097668001093	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1097668001094	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
1097668001095	PAS domain S-box; Region: sensory_box; TIGR00229
1097668001096	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668001097	putative active site [active]
1097668001098	heme pocket [chemical binding]; other site
1097668001099	PAS fold; Region: PAS_4; pfam08448
1097668001100	PAS domain; Region: PAS_9; pfam13426
1097668001101	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668001102	putative active site [active]
1097668001103	heme pocket [chemical binding]; other site
1097668001104	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668001105	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668001106	metal binding site [ion binding]; metal-binding site
1097668001107	active site
1097668001108	I-site; other site
1097668001109	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668001110	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1097668001111	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097668001112	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1097668001113	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
1097668001114	Walker A/P-loop; other site
1097668001115	ATP binding site [chemical binding]; other site
1097668001116	Q-loop/lid; other site
1097668001117	ABC transporter signature motif; other site
1097668001118	Walker B; other site
1097668001119	D-loop; other site
1097668001120	H-loop/switch region; other site
1097668001121	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1097668001122	cell density-dependent motility repressor; Provisional; Region: PRK10082
1097668001123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668001124	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668001125	dimerization interface [polypeptide binding]; other site
1097668001126	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1097668001127	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1097668001128	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1097668001129	NAD(P) binding site [chemical binding]; other site
1097668001130	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1097668001131	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668001132	substrate binding pocket [chemical binding]; other site
1097668001133	membrane-bound complex binding site; other site
1097668001134	hinge residues; other site
1097668001135	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668001136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668001137	dimer interface [polypeptide binding]; other site
1097668001138	conserved gate region; other site
1097668001139	putative PBP binding loops; other site
1097668001140	ABC-ATPase subunit interface; other site
1097668001141	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668001142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668001143	dimer interface [polypeptide binding]; other site
1097668001144	conserved gate region; other site
1097668001145	putative PBP binding loops; other site
1097668001146	ABC-ATPase subunit interface; other site
1097668001147	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668001148	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668001149	Walker A/P-loop; other site
1097668001150	ATP binding site [chemical binding]; other site
1097668001151	Q-loop/lid; other site
1097668001152	ABC transporter signature motif; other site
1097668001153	Walker B; other site
1097668001154	D-loop; other site
1097668001155	H-loop/switch region; other site
1097668001156	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1097668001157	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1097668001158	putative active site [active]
1097668001159	putative dimer interface [polypeptide binding]; other site
1097668001160	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1097668001161	active site
1097668001162	substrate binding pocket [chemical binding]; other site
1097668001163	dimer interface [polypeptide binding]; other site
1097668001164	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
1097668001165	OsmC-like protein; Region: OsmC; cl00767
1097668001166	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1097668001167	23S rRNA interface [nucleotide binding]; other site
1097668001168	L3 interface [polypeptide binding]; other site
1097668001169	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1097668001170	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1097668001171	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1097668001172	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1097668001173	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1097668001174	active site
1097668001175	HIGH motif; other site
1097668001176	dimer interface [polypeptide binding]; other site
1097668001177	KMSKS motif; other site
1097668001178	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1097668001179	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668001180	RNA binding surface [nucleotide binding]; other site
1097668001181	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1097668001182	putative active site [active]
1097668001183	dimerization interface [polypeptide binding]; other site
1097668001184	putative tRNAtyr binding site [nucleotide binding]; other site
1097668001185	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097668001186	catalytic core [active]
1097668001187	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1097668001188	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668001189	Walker A motif; other site
1097668001190	ATP binding site [chemical binding]; other site
1097668001191	Walker B motif; other site
1097668001192	arginine finger; other site
1097668001193	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1097668001194	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1097668001195	RuvA N terminal domain; Region: RuvA_N; pfam01330
1097668001196	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1097668001197	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1097668001198	active site
1097668001199	putative DNA-binding cleft [nucleotide binding]; other site
1097668001200	dimer interface [polypeptide binding]; other site
1097668001201	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1097668001202	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1097668001203	purine monophosphate binding site [chemical binding]; other site
1097668001204	dimer interface [polypeptide binding]; other site
1097668001205	putative catalytic residues [active]
1097668001206	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1097668001207	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1097668001208	DNA-binding protein Fis; Provisional; Region: PRK01905
1097668001209	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1097668001210	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1097668001211	FMN binding site [chemical binding]; other site
1097668001212	active site
1097668001213	catalytic residues [active]
1097668001214	substrate binding site [chemical binding]; other site
1097668001215	hypothetical protein; Provisional; Region: PRK06996
1097668001216	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668001217	proline aminopeptidase P II; Provisional; Region: PRK10879
1097668001218	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1097668001219	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1097668001220	active site
1097668001221	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1097668001222	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1097668001223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668001224	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1097668001225	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1097668001226	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1097668001227	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1097668001228	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1097668001229	ligand binding site [chemical binding]; other site
1097668001230	homodimer interface [polypeptide binding]; other site
1097668001231	NAD(P) binding site [chemical binding]; other site
1097668001232	trimer interface B [polypeptide binding]; other site
1097668001233	trimer interface A [polypeptide binding]; other site
1097668001234	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1097668001235	nudix motif; other site
1097668001236	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1097668001237	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1097668001238	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668001239	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668001240	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668001241	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668001242	putative glutathione S-transferase; Provisional; Region: PRK10357
1097668001243	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1097668001244	putative C-terminal domain interface [polypeptide binding]; other site
1097668001245	putative GSH binding site (G-site) [chemical binding]; other site
1097668001246	putative dimer interface [polypeptide binding]; other site
1097668001247	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1097668001248	dimer interface [polypeptide binding]; other site
1097668001249	N-terminal domain interface [polypeptide binding]; other site
1097668001250	putative substrate binding pocket (H-site) [chemical binding]; other site
1097668001251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1097668001252	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1097668001253	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1097668001254	mce related protein; Region: MCE; pfam02470
1097668001255	mce related protein; Region: MCE; pfam02470
1097668001256	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1097668001257	Paraquat-inducible protein A; Region: PqiA; pfam04403
1097668001258	Paraquat-inducible protein A; Region: PqiA; pfam04403
1097668001259	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1097668001260	YceI-like domain; Region: YceI; smart00867
1097668001261	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1097668001262	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1097668001263	Protein export membrane protein; Region: SecD_SecF; pfam02355
1097668001264	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1097668001265	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1097668001266	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1097668001267	Protein export membrane protein; Region: SecD_SecF; cl14618
1097668001268	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1097668001269	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1097668001270	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1097668001271	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1097668001272	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1097668001273	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1097668001274	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1097668001275	generic binding surface II; other site
1097668001276	ssDNA binding site; other site
1097668001277	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668001278	ATP binding site [chemical binding]; other site
1097668001279	putative Mg++ binding site [ion binding]; other site
1097668001280	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668001281	nucleotide binding region [chemical binding]; other site
1097668001282	ATP-binding site [chemical binding]; other site
1097668001283	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668001284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668001285	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1097668001286	dimerization interface [polypeptide binding]; other site
1097668001287	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1097668001288	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1097668001289	tetramer interface [polypeptide binding]; other site
1097668001290	heme binding pocket [chemical binding]; other site
1097668001291	NADPH binding site [chemical binding]; other site
1097668001292	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1097668001293	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1097668001294	dimerization interface [polypeptide binding]; other site
1097668001295	DPS ferroxidase diiron center [ion binding]; other site
1097668001296	ion pore; other site
1097668001297	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1097668001298	UbiA prenyltransferase family; Region: UbiA; pfam01040
1097668001299	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1097668001300	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1097668001301	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1097668001302	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668001303	catalytic residue [active]
1097668001304	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1097668001305	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1097668001306	Cysteine-rich domain; Region: CCG; pfam02754
1097668001307	Cysteine-rich domain; Region: CCG; pfam02754
1097668001308	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
1097668001309	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668001310	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
1097668001311	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668001312	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668001313	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668001314	Chlorite dismutase; Region: Chlor_dismutase; cl01280
1097668001315	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1097668001316	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1097668001317	protease TldD; Provisional; Region: tldD; PRK10735
1097668001318	nitrilase; Region: PLN02798
1097668001319	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1097668001320	putative active site [active]
1097668001321	catalytic triad [active]
1097668001322	dimer interface [polypeptide binding]; other site
1097668001323	TIGR02099 family protein; Region: TIGR02099
1097668001324	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1097668001325	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1097668001326	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1097668001327	metal binding triad; other site
1097668001328	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1097668001329	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1097668001330	metal binding triad; other site
1097668001331	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1097668001332	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1097668001333	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1097668001334	Walker A/P-loop; other site
1097668001335	ATP binding site [chemical binding]; other site
1097668001336	Q-loop/lid; other site
1097668001337	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1097668001338	ABC transporter signature motif; other site
1097668001339	Walker B; other site
1097668001340	D-loop; other site
1097668001341	H-loop/switch region; other site
1097668001342	NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155
1097668001343	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1097668001344	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1097668001345	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1097668001346	ferrochelatase; Reviewed; Region: hemH; PRK00035
1097668001347	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1097668001348	C-terminal domain interface [polypeptide binding]; other site
1097668001349	active site
1097668001350	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1097668001351	active site
1097668001352	N-terminal domain interface [polypeptide binding]; other site
1097668001353	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668001354	RNA binding surface [nucleotide binding]; other site
1097668001355	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1097668001356	dimer interface [polypeptide binding]; other site
1097668001357	GrpE; Region: GrpE; pfam01025
1097668001358	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1097668001359	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1097668001360	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097668001361	nucleotide binding site [chemical binding]; other site
1097668001362	chaperone protein DnaJ; Provisional; Region: PRK10767
1097668001363	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1097668001364	HSP70 interaction site [polypeptide binding]; other site
1097668001365	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1097668001366	Zn binding sites [ion binding]; other site
1097668001367	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1097668001368	dimer interface [polypeptide binding]; other site
1097668001369	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1097668001370	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1097668001371	hypothetical protein; Provisional; Region: PRK07546
1097668001372	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1097668001373	substrate-cofactor binding pocket; other site
1097668001374	homodimer interface [polypeptide binding]; other site
1097668001375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668001376	catalytic residue [active]
1097668001377	galactonate dehydratase; Provisional; Region: PRK14017
1097668001378	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1097668001379	putative active site pocket [active]
1097668001380	putative metal binding site [ion binding]; other site
1097668001381	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668001382	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668001383	DNA-binding site [nucleotide binding]; DNA binding site
1097668001384	FCD domain; Region: FCD; pfam07729
1097668001385	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1097668001386	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1097668001387	trimer interface [polypeptide binding]; other site
1097668001388	Haemagglutinin; Region: HIM; pfam05662
1097668001389	Haemagglutinin; Region: HIM; pfam05662
1097668001390	Haemagglutinin; Region: HIM; pfam05662
1097668001391	EamA-like transporter family; Region: EamA; pfam00892
1097668001392	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1097668001393	EamA-like transporter family; Region: EamA; pfam00892
1097668001394	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668001395	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1097668001396	dimer interface [polypeptide binding]; other site
1097668001397	active site
1097668001398	metal binding site [ion binding]; metal-binding site
1097668001399	glutathione binding site [chemical binding]; other site
1097668001400	Protein of unknown function DUF45; Region: DUF45; pfam01863
1097668001401	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1097668001402	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097668001403	putative acyl-acceptor binding pocket; other site
1097668001404	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1097668001405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668001406	active site
1097668001407	motif I; other site
1097668001408	motif II; other site
1097668001409	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1097668001410	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1097668001411	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1097668001412	dimer interface [polypeptide binding]; other site
1097668001413	motif 1; other site
1097668001414	active site
1097668001415	motif 2; other site
1097668001416	motif 3; other site
1097668001417	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1097668001418	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1097668001419	putative active site [active]
1097668001420	catalytic triad [active]
1097668001421	putative dimer interface [polypeptide binding]; other site
1097668001422	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1097668001423	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1097668001424	Transporter associated domain; Region: CorC_HlyC; smart01091
1097668001425	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1097668001426	putative active site pocket [active]
1097668001427	dimerization interface [polypeptide binding]; other site
1097668001428	putative catalytic residue [active]
1097668001429	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
1097668001430	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1097668001431	PhoH-like protein; Region: PhoH; pfam02562
1097668001432	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1097668001433	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1097668001434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668001435	FeS/SAM binding site; other site
1097668001436	TRAM domain; Region: TRAM; pfam01938
1097668001437	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668001438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668001439	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668001440	putative effector binding pocket; other site
1097668001441	dimerization interface [polypeptide binding]; other site
1097668001442	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1097668001443	active site
1097668001444	metal binding site [ion binding]; metal-binding site
1097668001445	MFS transport protein AraJ; Provisional; Region: PRK10091
1097668001446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668001447	putative substrate translocation pore; other site
1097668001448	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1097668001449	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668001450	motif II; other site
1097668001451	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1097668001452	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1097668001453	glycerol kinase; Provisional; Region: glpK; PRK00047
1097668001454	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1097668001455	N- and C-terminal domain interface [polypeptide binding]; other site
1097668001456	active site
1097668001457	MgATP binding site [chemical binding]; other site
1097668001458	catalytic site [active]
1097668001459	metal binding site [ion binding]; metal-binding site
1097668001460	glycerol binding site [chemical binding]; other site
1097668001461	homotetramer interface [polypeptide binding]; other site
1097668001462	homodimer interface [polypeptide binding]; other site
1097668001463	FBP binding site [chemical binding]; other site
1097668001464	protein IIAGlc interface [polypeptide binding]; other site
1097668001465	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1097668001466	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1097668001467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668001468	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668001469	putative substrate translocation pore; other site
1097668001470	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1097668001471	dinuclear metal binding motif [ion binding]; other site
1097668001472	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1097668001473	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097668001474	ATP binding site [chemical binding]; other site
1097668001475	Mg++ binding site [ion binding]; other site
1097668001476	motif III; other site
1097668001477	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668001478	nucleotide binding region [chemical binding]; other site
1097668001479	ATP-binding site [chemical binding]; other site
1097668001480	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1097668001481	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1097668001482	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668001483	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668001484	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668001485	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1097668001486	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668001487	Cytochrome c; Region: Cytochrom_C; cl11414
1097668001488	Copper resistance protein D; Region: CopD; cl00563
1097668001489	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1097668001490	oligomerization interface [polypeptide binding]; other site
1097668001491	active site
1097668001492	metal binding site [ion binding]; metal-binding site
1097668001493	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1097668001494	Substrate-binding site [chemical binding]; other site
1097668001495	Substrate specificity [chemical binding]; other site
1097668001496	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1097668001497	catalytic center binding site [active]
1097668001498	ATP binding site [chemical binding]; other site
1097668001499	poly(A) polymerase; Region: pcnB; TIGR01942
1097668001500	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1097668001501	active site
1097668001502	NTP binding site [chemical binding]; other site
1097668001503	metal binding triad [ion binding]; metal-binding site
1097668001504	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1097668001505	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1097668001506	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1097668001507	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1097668001508	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1097668001509	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
1097668001510	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1097668001511	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1097668001512	dimerization interface [polypeptide binding]; other site
1097668001513	putative ATP binding site [chemical binding]; other site
1097668001514	Uncharacterized conserved protein [Function unknown]; Region: COG2361
1097668001515	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1097668001516	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1097668001517	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1097668001518	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1097668001519	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668001520	ATP binding site [chemical binding]; other site
1097668001521	Mg2+ binding site [ion binding]; other site
1097668001522	G-X-G motif; other site
1097668001523	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1097668001524	ATP binding site [chemical binding]; other site
1097668001525	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1097668001526	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1097668001527	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097668001528	Predicted membrane protein [Function unknown]; Region: COG2261
1097668001529	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097668001530	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1097668001531	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097668001532	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1097668001533	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668001534	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1097668001535	substrate binding pocket [chemical binding]; other site
1097668001536	membrane-bound complex binding site; other site
1097668001537	hinge residues; other site
1097668001538	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668001539	hypothetical protein; Provisional; Region: PRK07483
1097668001540	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668001541	inhibitor-cofactor binding pocket; inhibition site
1097668001542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668001543	catalytic residue [active]
1097668001544	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097668001545	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097668001546	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097668001547	putative active site [active]
1097668001548	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1097668001549	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1097668001550	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1097668001551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668001552	putative substrate translocation pore; other site
1097668001553	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1097668001554	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668001555	HAMP domain; Region: HAMP; pfam00672
1097668001556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668001557	dimer interface [polypeptide binding]; other site
1097668001558	phosphorylation site [posttranslational modification]
1097668001559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668001560	ATP binding site [chemical binding]; other site
1097668001561	Mg2+ binding site [ion binding]; other site
1097668001562	G-X-G motif; other site
1097668001563	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668001564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668001565	active site
1097668001566	phosphorylation site [posttranslational modification]
1097668001567	intermolecular recognition site; other site
1097668001568	dimerization interface [polypeptide binding]; other site
1097668001569	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668001570	DNA binding site [nucleotide binding]
1097668001571	recombinase A; Provisional; Region: recA; PRK09354
1097668001572	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1097668001573	hexamer interface [polypeptide binding]; other site
1097668001574	Walker A motif; other site
1097668001575	ATP binding site [chemical binding]; other site
1097668001576	Walker B motif; other site
1097668001577	RecX family; Region: RecX; cl00936
1097668001578	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
1097668001579	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1097668001580	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1097668001581	CoA-ligase; Region: Ligase_CoA; pfam00549
1097668001582	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1097668001583	CoA binding domain; Region: CoA_binding; smart00881
1097668001584	CoA-ligase; Region: Ligase_CoA; pfam00549
1097668001585	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1097668001586	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
1097668001587	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1097668001588	Pilin (bacterial filament); Region: Pilin; pfam00114
1097668001589	O-Antigen ligase; Region: Wzy_C; pfam04932
1097668001590	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
1097668001591	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1097668001592	trimer interface [polypeptide binding]; other site
1097668001593	dimer interface [polypeptide binding]; other site
1097668001594	putative active site [active]
1097668001595	Peptidase family M48; Region: Peptidase_M48; cl12018
1097668001596	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
1097668001597	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
1097668001598	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1097668001599	SnoaL-like domain; Region: SnoaL_3; pfam13474
1097668001600	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1097668001601	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1097668001602	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1097668001603	putative active site [active]
1097668001604	Zinc-finger domain; Region: zf-CHCC; cl01821
1097668001605	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1097668001606	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1097668001607	homodimer interface [polypeptide binding]; other site
1097668001608	substrate-cofactor binding pocket; other site
1097668001609	catalytic residue [active]
1097668001610	AzlC protein; Region: AzlC; cl00570
1097668001611	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1097668001612	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1097668001613	Phosphoglycerate kinase; Region: PGK; pfam00162
1097668001614	substrate binding site [chemical binding]; other site
1097668001615	hinge regions; other site
1097668001616	ADP binding site [chemical binding]; other site
1097668001617	catalytic site [active]
1097668001618	pyruvate kinase; Provisional; Region: PRK05826
1097668001619	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1097668001620	domain interfaces; other site
1097668001621	active site
1097668001622	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1097668001623	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1097668001624	intersubunit interface [polypeptide binding]; other site
1097668001625	active site
1097668001626	zinc binding site [ion binding]; other site
1097668001627	Na+ binding site [ion binding]; other site
1097668001628	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1097668001629	ATP binding site [chemical binding]; other site
1097668001630	active site
1097668001631	substrate binding site [chemical binding]; other site
1097668001632	AIR carboxylase; Region: AIRC; pfam00731
1097668001633	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1097668001634	ATP-grasp domain; Region: ATP-grasp; pfam02222
1097668001635	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1097668001636	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1097668001637	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
1097668001638	active site
1097668001639	catalytic triad [active]
1097668001640	oxyanion hole [active]
1097668001641	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1097668001642	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1097668001643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668001644	active site
1097668001645	phosphorylation site [posttranslational modification]
1097668001646	intermolecular recognition site; other site
1097668001647	dimerization interface [polypeptide binding]; other site
1097668001648	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668001649	DNA binding site [nucleotide binding]
1097668001650	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668001651	dimer interface [polypeptide binding]; other site
1097668001652	phosphorylation site [posttranslational modification]
1097668001653	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668001654	ATP binding site [chemical binding]; other site
1097668001655	Mg2+ binding site [ion binding]; other site
1097668001656	G-X-G motif; other site
1097668001657	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1097668001658	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097668001659	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668001660	protein binding site [polypeptide binding]; other site
1097668001661	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668001662	protein binding site [polypeptide binding]; other site
1097668001663	Domain of unknown function (DUF427); Region: DUF427; pfam04248
1097668001664	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668001665	hydrophobic ligand binding site; other site
1097668001666	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1097668001667	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668001668	conserved cys residue [active]
1097668001669	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668001670	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668001671	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1097668001672	catalytic triad [active]
1097668001673	conserved cis-peptide bond; other site
1097668001674	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1097668001675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668001676	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1097668001677	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1097668001678	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668001679	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668001680	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1097668001681	Protein export membrane protein; Region: SecD_SecF; cl14618
1097668001682	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668001683	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
1097668001684	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668001685	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668001686	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1097668001687	Protein export membrane protein; Region: SecD_SecF; cl14618
1097668001688	Protein export membrane protein; Region: SecD_SecF; cl14618
1097668001689	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
1097668001690	xanthine permease; Region: pbuX; TIGR03173
1097668001691	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097668001692	D-xylulose kinase; Region: XylB; TIGR01312
1097668001693	nucleotide binding site [chemical binding]; other site
1097668001694	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1097668001695	dimerization interface [polypeptide binding]; other site
1097668001696	putative active cleft [active]
1097668001697	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1097668001698	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1097668001699	substrate binding site [chemical binding]; other site
1097668001700	catalytic Zn binding site [ion binding]; other site
1097668001701	NAD binding site [chemical binding]; other site
1097668001702	structural Zn binding site [ion binding]; other site
1097668001703	dimer interface [polypeptide binding]; other site
1097668001704	S-formylglutathione hydrolase; Region: PLN02442
1097668001705	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1097668001706	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1097668001707	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097668001708	ABC-ATPase subunit  interface; other site
1097668001709	dimer interface [polypeptide binding]; other site
1097668001710	putative PBP binding regions; other site
1097668001711	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1097668001712	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668001713	Walker A/P-loop; other site
1097668001714	ATP binding site [chemical binding]; other site
1097668001715	Q-loop/lid; other site
1097668001716	ABC transporter signature motif; other site
1097668001717	Walker B; other site
1097668001718	D-loop; other site
1097668001719	H-loop/switch region; other site
1097668001720	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
1097668001721	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1097668001722	metal binding site [ion binding]; metal-binding site
1097668001723	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1097668001724	metal binding site 2 [ion binding]; metal-binding site
1097668001725	putative DNA binding helix; other site
1097668001726	metal binding site 1 [ion binding]; metal-binding site
1097668001727	dimer interface [polypeptide binding]; other site
1097668001728	structural Zn2+ binding site [ion binding]; other site
1097668001729	sorbitol dehydrogenase; Provisional; Region: PRK07067
1097668001730	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668001731	NAD(P) binding site [chemical binding]; other site
1097668001732	active site
1097668001733	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097668001734	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668001735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097668001736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668001737	dimer interface [polypeptide binding]; other site
1097668001738	conserved gate region; other site
1097668001739	putative PBP binding loops; other site
1097668001740	ABC-ATPase subunit interface; other site
1097668001741	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097668001742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668001743	dimer interface [polypeptide binding]; other site
1097668001744	conserved gate region; other site
1097668001745	putative PBP binding loops; other site
1097668001746	ABC-ATPase subunit interface; other site
1097668001747	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1097668001748	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668001749	motif II; other site
1097668001750	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1097668001751	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1097668001752	Walker A/P-loop; other site
1097668001753	ATP binding site [chemical binding]; other site
1097668001754	Q-loop/lid; other site
1097668001755	ABC transporter signature motif; other site
1097668001756	Walker B; other site
1097668001757	D-loop; other site
1097668001758	H-loop/switch region; other site
1097668001759	TOBE domain; Region: TOBE; pfam03459
1097668001760	TOBE domain; Region: TOBE_2; pfam08402
1097668001761	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1097668001762	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1097668001763	MOSC domain; Region: MOSC; pfam03473
1097668001764	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1097668001765	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1097668001766	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1097668001767	N- and C-terminal domain interface [polypeptide binding]; other site
1097668001768	D-xylulose kinase; Region: XylB; TIGR01312
1097668001769	active site
1097668001770	MgATP binding site [chemical binding]; other site
1097668001771	catalytic site [active]
1097668001772	metal binding site [ion binding]; metal-binding site
1097668001773	xylulose binding site [chemical binding]; other site
1097668001774	homodimer interface [polypeptide binding]; other site
1097668001775	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1097668001776	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1097668001777	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1097668001778	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1097668001779	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
1097668001780	N- and C-terminal domain interface [polypeptide binding]; other site
1097668001781	putative active site [active]
1097668001782	MgATP binding site [chemical binding]; other site
1097668001783	catalytic site [active]
1097668001784	metal binding site [ion binding]; metal-binding site
1097668001785	putative xylulose binding site [chemical binding]; other site
1097668001786	putative homodimer interface [polypeptide binding]; other site
1097668001787	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1097668001788	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
1097668001789	fumarylacetoacetase; Region: PLN02856
1097668001790	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1097668001791	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668001792	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668001793	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668001794	putative substrate translocation pore; other site
1097668001795	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1097668001796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668001797	putative substrate translocation pore; other site
1097668001798	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
1097668001799	putative active site [active]
1097668001800	putative metal binding site [ion binding]; other site
1097668001801	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
1097668001802	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668001803	ATP binding site [chemical binding]; other site
1097668001804	putative Mg++ binding site [ion binding]; other site
1097668001805	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668001806	nucleotide binding region [chemical binding]; other site
1097668001807	ATP-binding site [chemical binding]; other site
1097668001808	DEAD/H associated; Region: DEAD_assoc; pfam08494
1097668001809	ATP-dependent DNA ligase; Validated; Region: PRK09247
1097668001810	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
1097668001811	active site
1097668001812	DNA binding site [nucleotide binding]
1097668001813	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1097668001814	DNA binding site [nucleotide binding]
1097668001815	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
1097668001816	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668001817	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668001818	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668001819	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668001820	dimerization interface [polypeptide binding]; other site
1097668001821	putative effector binding pocket; other site
1097668001822	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668001823	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668001824	active site
1097668001825	catalytic tetrad [active]
1097668001826	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1097668001827	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668001828	Walker A/P-loop; other site
1097668001829	ATP binding site [chemical binding]; other site
1097668001830	Q-loop/lid; other site
1097668001831	ABC transporter signature motif; other site
1097668001832	Walker B; other site
1097668001833	D-loop; other site
1097668001834	H-loop/switch region; other site
1097668001835	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668001836	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668001837	Walker A/P-loop; other site
1097668001838	ATP binding site [chemical binding]; other site
1097668001839	Q-loop/lid; other site
1097668001840	ABC transporter signature motif; other site
1097668001841	Walker B; other site
1097668001842	D-loop; other site
1097668001843	H-loop/switch region; other site
1097668001844	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1097668001845	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097668001846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668001847	putative PBP binding loops; other site
1097668001848	dimer interface [polypeptide binding]; other site
1097668001849	ABC-ATPase subunit interface; other site
1097668001850	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097668001851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668001852	dimer interface [polypeptide binding]; other site
1097668001853	conserved gate region; other site
1097668001854	putative PBP binding loops; other site
1097668001855	ABC-ATPase subunit interface; other site
1097668001856	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668001857	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1097668001858	Cupin domain; Region: Cupin_2; cl17218
1097668001859	elongation factor G; Reviewed; Region: PRK00007
1097668001860	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1097668001861	G1 box; other site
1097668001862	putative GEF interaction site [polypeptide binding]; other site
1097668001863	GTP/Mg2+ binding site [chemical binding]; other site
1097668001864	Switch I region; other site
1097668001865	G2 box; other site
1097668001866	G3 box; other site
1097668001867	Switch II region; other site
1097668001868	G4 box; other site
1097668001869	G5 box; other site
1097668001870	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1097668001871	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1097668001872	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1097668001873	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1097668001874	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1097668001875	pseudouridine synthase; Region: TIGR00093
1097668001876	active site
1097668001877	isocitrate dehydrogenase; Validated; Region: PRK07362
1097668001878	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1097668001879	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668001880	DNA-binding site [nucleotide binding]; DNA binding site
1097668001881	RNA-binding motif; other site
1097668001882	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1097668001883	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1097668001884	Clp amino terminal domain; Region: Clp_N; pfam02861
1097668001885	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668001886	Walker A motif; other site
1097668001887	ATP binding site [chemical binding]; other site
1097668001888	Walker B motif; other site
1097668001889	arginine finger; other site
1097668001890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668001891	Walker A motif; other site
1097668001892	ATP binding site [chemical binding]; other site
1097668001893	Walker B motif; other site
1097668001894	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1097668001895	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1097668001896	trimer interface [polypeptide binding]; other site
1097668001897	active site
1097668001898	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1097668001899	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1097668001900	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1097668001901	Flavoprotein; Region: Flavoprotein; pfam02441
1097668001902	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1097668001903	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1097668001904	lipoprotein signal peptidase; Provisional; Region: PRK14787
1097668001905	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1097668001906	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097668001907	active site
1097668001908	HIGH motif; other site
1097668001909	nucleotide binding site [chemical binding]; other site
1097668001910	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1097668001911	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1097668001912	active site
1097668001913	KMSKS motif; other site
1097668001914	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1097668001915	tRNA binding surface [nucleotide binding]; other site
1097668001916	anticodon binding site; other site
1097668001917	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1097668001918	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1097668001919	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1097668001920	active site
1097668001921	Riboflavin kinase; Region: Flavokinase; smart00904
1097668001922	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1097668001923	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1097668001924	active site
1097668001925	substrate binding site [chemical binding]; other site
1097668001926	cosubstrate binding site; other site
1097668001927	catalytic site [active]
1097668001928	16S rRNA methyltransferase B; Provisional; Region: PRK14901
1097668001929	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1097668001930	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668001931	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668001932	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1097668001933	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1097668001934	Di-iron ligands [ion binding]; other site
1097668001935	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1097668001936	quinolinate synthetase; Provisional; Region: PRK09375
1097668001937	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
1097668001938	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1097668001939	dimerization interface [polypeptide binding]; other site
1097668001940	active site
1097668001941	L-aspartate oxidase; Provisional; Region: PRK09077
1097668001942	L-aspartate oxidase; Provisional; Region: PRK06175
1097668001943	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1097668001944	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1097668001945	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1097668001946	hypothetical protein; Reviewed; Region: PRK00024
1097668001947	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1097668001948	MPN+ (JAMM) motif; other site
1097668001949	Zinc-binding site [ion binding]; other site
1097668001950	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1097668001951	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1097668001952	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1097668001953	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1097668001954	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668001955	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668001956	dimerization interface [polypeptide binding]; other site
1097668001957	ligand binding site [chemical binding]; other site
1097668001958	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668001959	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668001960	TM-ABC transporter signature motif; other site
1097668001961	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668001962	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668001963	TM-ABC transporter signature motif; other site
1097668001964	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668001965	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668001966	Walker A/P-loop; other site
1097668001967	ATP binding site [chemical binding]; other site
1097668001968	Q-loop/lid; other site
1097668001969	ABC transporter signature motif; other site
1097668001970	Walker B; other site
1097668001971	D-loop; other site
1097668001972	H-loop/switch region; other site
1097668001973	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668001974	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668001975	Walker A/P-loop; other site
1097668001976	ATP binding site [chemical binding]; other site
1097668001977	Q-loop/lid; other site
1097668001978	ABC transporter signature motif; other site
1097668001979	Walker B; other site
1097668001980	D-loop; other site
1097668001981	H-loop/switch region; other site
1097668001982	putative acetyltransferase; Provisional; Region: PRK03624
1097668001983	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668001984	Coenzyme A binding pocket [chemical binding]; other site
1097668001985	acetylornithine transaminase protein; Provisional; Region: argD; PRK03715
1097668001986	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668001987	inhibitor-cofactor binding pocket; inhibition site
1097668001988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668001989	catalytic residue [active]
1097668001990	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1097668001991	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668001992	catalytic loop [active]
1097668001993	iron binding site [ion binding]; other site
1097668001994	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1097668001995	FAD binding pocket [chemical binding]; other site
1097668001996	FAD binding motif [chemical binding]; other site
1097668001997	phosphate binding motif [ion binding]; other site
1097668001998	beta-alpha-beta structure motif; other site
1097668001999	NAD binding pocket [chemical binding]; other site
1097668002000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668002001	NAD(P) binding site [chemical binding]; other site
1097668002002	active site
1097668002003	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668002004	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668002005	RNA binding surface [nucleotide binding]; other site
1097668002006	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1097668002007	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1097668002008	active site
1097668002009	uracil binding [chemical binding]; other site
1097668002010	TIGR03118 family protein; Region: PEPCTERM_chp_1
1097668002011	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1097668002012	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1097668002013	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668002014	putative ligand binding site [chemical binding]; other site
1097668002015	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
1097668002016	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668002017	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1097668002018	substrate binding site [chemical binding]; other site
1097668002019	dimerization interface [polypeptide binding]; other site
1097668002020	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1097668002021	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1097668002022	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1097668002023	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
1097668002024	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1097668002025	Active Sites [active]
1097668002026	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1097668002027	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1097668002028	Active Sites [active]
1097668002029	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668002030	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
1097668002031	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1097668002032	CysD dimerization site [polypeptide binding]; other site
1097668002033	G1 box; other site
1097668002034	putative GEF interaction site [polypeptide binding]; other site
1097668002035	GTP/Mg2+ binding site [chemical binding]; other site
1097668002036	Switch I region; other site
1097668002037	G2 box; other site
1097668002038	G3 box; other site
1097668002039	Switch II region; other site
1097668002040	G4 box; other site
1097668002041	G5 box; other site
1097668002042	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1097668002043	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1097668002044	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1097668002045	active site
1097668002046	SAM binding site [chemical binding]; other site
1097668002047	homodimer interface [polypeptide binding]; other site
1097668002048	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
1097668002049	putative active site [active]
1097668002050	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1097668002051	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1097668002052	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1097668002053	putative active site [active]
1097668002054	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1097668002055	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1097668002056	Predicted permeases [General function prediction only]; Region: COG0795
1097668002057	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1097668002058	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1097668002059	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1097668002060	interface (dimer of trimers) [polypeptide binding]; other site
1097668002061	Substrate-binding/catalytic site; other site
1097668002062	Zn-binding sites [ion binding]; other site
1097668002063	DNA polymerase III subunit chi; Validated; Region: PRK05728
1097668002064	Protein of unknown function (DUF2486); Region: DUF2486; pfam10667
1097668002065	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1097668002066	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1097668002067	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1097668002068	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1097668002069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668002070	The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453
1097668002071	putative dimerization interface [polypeptide binding]; other site
1097668002072	putative substrate binding pocket [chemical binding]; other site
1097668002073	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1097668002074	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1097668002075	EVE domain; Region: EVE; cl00728
1097668002076	Cell division protein ZapA; Region: ZapA; pfam05164
1097668002077	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1097668002078	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668002079	N-terminal plug; other site
1097668002080	ligand-binding site [chemical binding]; other site
1097668002081	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1097668002082	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097668002083	ABC-ATPase subunit  interface; other site
1097668002084	dimer interface [polypeptide binding]; other site
1097668002085	putative PBP binding regions; other site
1097668002086	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1097668002087	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1097668002088	Walker A/P-loop; other site
1097668002089	ATP binding site [chemical binding]; other site
1097668002090	Q-loop/lid; other site
1097668002091	ABC transporter signature motif; other site
1097668002092	Walker B; other site
1097668002093	D-loop; other site
1097668002094	H-loop/switch region; other site
1097668002095	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1097668002096	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1097668002097	putative dimer interface [polypeptide binding]; other site
1097668002098	active site pocket [active]
1097668002099	putative cataytic base [active]
1097668002100	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1097668002101	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097668002102	catalytic core [active]
1097668002103	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
1097668002104	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1097668002105	cobalamin binding residues [chemical binding]; other site
1097668002106	putative BtuC binding residues; other site
1097668002107	dimer interface [polypeptide binding]; other site
1097668002108	putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959
1097668002109	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1097668002110	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668002111	catalytic residue [active]
1097668002112	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1097668002113	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1097668002114	homotrimer interface [polypeptide binding]; other site
1097668002115	Walker A motif; other site
1097668002116	GTP binding site [chemical binding]; other site
1097668002117	Walker B motif; other site
1097668002118	cobyric acid synthase; Provisional; Region: PRK00784
1097668002119	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668002120	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1097668002121	catalytic triad [active]
1097668002122	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097668002123	CoenzymeA binding site [chemical binding]; other site
1097668002124	subunit interaction site [polypeptide binding]; other site
1097668002125	PHB binding site; other site
1097668002126	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097668002127	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668002128	P-loop; other site
1097668002129	Magnesium ion binding site [ion binding]; other site
1097668002130	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1097668002131	tetramerization interface [polypeptide binding]; other site
1097668002132	active site
1097668002133	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1097668002134	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1097668002135	active site
1097668002136	ATP-binding site [chemical binding]; other site
1097668002137	pantoate-binding site; other site
1097668002138	HXXH motif; other site
1097668002139	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1097668002140	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
1097668002141	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1097668002142	Surface antigen; Region: Bac_surface_Ag; pfam01103
1097668002143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1097668002144	Family of unknown function (DUF490); Region: DUF490; pfam04357
1097668002145	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1097668002146	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1097668002147	active site
1097668002148	HIGH motif; other site
1097668002149	KMSKS motif; other site
1097668002150	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1097668002151	tRNA binding surface [nucleotide binding]; other site
1097668002152	anticodon binding site; other site
1097668002153	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1097668002154	dimer interface [polypeptide binding]; other site
1097668002155	putative tRNA-binding site [nucleotide binding]; other site
1097668002156	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1097668002157	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668002158	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668002159	ligand binding site [chemical binding]; other site
1097668002160	Domain of unknown function DUF59; Region: DUF59; pfam01883
1097668002161	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1097668002162	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1097668002163	Walker A motif; other site
1097668002164	Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080
1097668002165	E-class dimer interface [polypeptide binding]; other site
1097668002166	P-class dimer interface [polypeptide binding]; other site
1097668002167	active site
1097668002168	Cu2+ binding site [ion binding]; other site
1097668002169	Zn2+ binding site [ion binding]; other site
1097668002170	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1097668002171	trimer interface [polypeptide binding]; other site
1097668002172	active site
1097668002173	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1097668002174	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1097668002175	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097668002176	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668002177	catalytic residue [active]
1097668002178	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1097668002179	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
1097668002180	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668002181	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1097668002182	glutathionine S-transferase; Provisional; Region: PRK10542
1097668002183	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1097668002184	C-terminal domain interface [polypeptide binding]; other site
1097668002185	GSH binding site (G-site) [chemical binding]; other site
1097668002186	dimer interface [polypeptide binding]; other site
1097668002187	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1097668002188	dimer interface [polypeptide binding]; other site
1097668002189	N-terminal domain interface [polypeptide binding]; other site
1097668002190	substrate binding pocket (H-site) [chemical binding]; other site
1097668002191	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1097668002192	argininosuccinate lyase; Provisional; Region: PRK00855
1097668002193	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1097668002194	active sites [active]
1097668002195	tetramer interface [polypeptide binding]; other site
1097668002196	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668002197	non-specific DNA binding site [nucleotide binding]; other site
1097668002198	salt bridge; other site
1097668002199	sequence-specific DNA binding site [nucleotide binding]; other site
1097668002200	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668002201	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1097668002202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668002203	S-adenosylmethionine binding site [chemical binding]; other site
1097668002204	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1097668002205	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1097668002206	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1097668002207	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1097668002208	domain interfaces; other site
1097668002209	active site
1097668002210	bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975
1097668002211	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1097668002212	active site
1097668002213	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
1097668002214	HemY protein N-terminus; Region: HemY_N; pfam07219
1097668002215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668002216	TPR motif; other site
1097668002217	binding surface
1097668002218	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1097668002219	active site
1097668002220	oxyanion hole [active]
1097668002221	catalytic triad [active]
1097668002222	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
1097668002223	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1097668002224	dimerization interface [polypeptide binding]; other site
1097668002225	mannose binding site [chemical binding]; other site
1097668002226	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1097668002227	active site residue [active]
1097668002228	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1097668002229	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668002230	S-adenosylmethionine binding site [chemical binding]; other site
1097668002231	Predicted membrane protein [Function unknown]; Region: COG2860
1097668002232	UPF0126 domain; Region: UPF0126; pfam03458
1097668002233	UPF0126 domain; Region: UPF0126; pfam03458
1097668002234	Smr domain; Region: Smr; pfam01713
1097668002235	thioredoxin reductase; Provisional; Region: PRK10262
1097668002236	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668002237	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668002238	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1097668002239	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1097668002240	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1097668002241	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1097668002242	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
1097668002243	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668002244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668002245	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668002246	dimerization interface [polypeptide binding]; other site
1097668002247	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1097668002248	agmatinase; Region: agmatinase; TIGR01230
1097668002249	oligomer interface [polypeptide binding]; other site
1097668002250	putative active site [active]
1097668002251	Mn binding site [ion binding]; other site
1097668002252	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097668002253	recombination factor protein RarA; Reviewed; Region: PRK13342
1097668002254	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668002255	Walker A motif; other site
1097668002256	ATP binding site [chemical binding]; other site
1097668002257	Walker B motif; other site
1097668002258	arginine finger; other site
1097668002259	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1097668002260	seryl-tRNA synthetase; Provisional; Region: PRK05431
1097668002261	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1097668002262	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1097668002263	dimer interface [polypeptide binding]; other site
1097668002264	active site
1097668002265	motif 1; other site
1097668002266	motif 2; other site
1097668002267	motif 3; other site
1097668002268	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1097668002269	active site
1097668002270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668002271	Coenzyme A binding pocket [chemical binding]; other site
1097668002272	septum formation inhibitor; Reviewed; Region: PRK01973
1097668002273	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1097668002274	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1097668002275	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1097668002276	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1097668002277	Switch I; other site
1097668002278	Switch II; other site
1097668002279	cell division topological specificity factor MinE; Provisional; Region: PRK13989
1097668002280	OpgC protein; Region: OpgC_C; pfam10129
1097668002281	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668002282	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668002283	putative substrate translocation pore; other site
1097668002284	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1097668002285	enterobactin exporter EntS; Provisional; Region: PRK10489
1097668002286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668002287	putative substrate translocation pore; other site
1097668002288	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
1097668002289	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668002290	FeS/SAM binding site; other site
1097668002291	HemN C-terminal domain; Region: HemN_C; pfam06969
1097668002292	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1097668002293	active site
1097668002294	dimerization interface [polypeptide binding]; other site
1097668002295	ribonuclease PH; Reviewed; Region: rph; PRK00173
1097668002296	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1097668002297	hexamer interface [polypeptide binding]; other site
1097668002298	active site
1097668002299	hypothetical protein; Provisional; Region: PRK11820
1097668002300	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1097668002301	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1097668002302	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1097668002303	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1097668002304	catalytic site [active]
1097668002305	G-X2-G-X-G-K; other site
1097668002306	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1097668002307	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1097668002308	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097668002309	Zn2+ binding site [ion binding]; other site
1097668002310	Mg2+ binding site [ion binding]; other site
1097668002311	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1097668002312	synthetase active site [active]
1097668002313	NTP binding site [chemical binding]; other site
1097668002314	metal binding site [ion binding]; metal-binding site
1097668002315	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1097668002316	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1097668002317	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
1097668002318	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1097668002319	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1097668002320	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1097668002321	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668002322	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668002323	trimer interface [polypeptide binding]; other site
1097668002324	eyelet of channel; other site
1097668002325	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1097668002326	active site
1097668002327	catalytic site [active]
1097668002328	substrate binding site [chemical binding]; other site
1097668002329	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1097668002330	GIY-YIG motif/motif A; other site
1097668002331	active site
1097668002332	catalytic site [active]
1097668002333	putative DNA binding site [nucleotide binding]; other site
1097668002334	metal binding site [ion binding]; metal-binding site
1097668002335	chorismate mutase; Provisional; Region: PRK09269
1097668002336	Chorismate mutase type II; Region: CM_2; cl00693
1097668002337	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1097668002338	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1097668002339	AMP binding site [chemical binding]; other site
1097668002340	metal binding site [ion binding]; metal-binding site
1097668002341	active site
1097668002342	aminopeptidase N; Provisional; Region: pepN; PRK14015
1097668002343	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1097668002344	active site
1097668002345	Zn binding site [ion binding]; other site
1097668002346	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1097668002347	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1097668002348	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1097668002349	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1097668002350	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1097668002351	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
1097668002352	active site
1097668002353	metal-binding site
1097668002354	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668002355	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668002356	tetramer interface [polypeptide binding]; other site
1097668002357	active site
1097668002358	Mg2+/Mn2+ binding site [ion binding]; other site
1097668002359	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
1097668002360	active site
1097668002361	metal-binding site
1097668002362	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668002363	phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297
1097668002364	PYR/PP interface [polypeptide binding]; other site
1097668002365	dimer interface [polypeptide binding]; other site
1097668002366	TPP binding site [chemical binding]; other site
1097668002367	Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371
1097668002368	TPP-binding site; other site
1097668002369	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097668002370	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668002371	catalytic residue [active]
1097668002372	guanine deaminase; Provisional; Region: PRK09228
1097668002373	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1097668002374	active site
1097668002375	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1097668002376	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1097668002377	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1097668002378	active site
1097668002379	purine riboside binding site [chemical binding]; other site
1097668002380	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1097668002381	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1097668002382	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1097668002383	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1097668002384	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668002385	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668002386	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1097668002387	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668002388	catalytic loop [active]
1097668002389	iron binding site [ion binding]; other site
1097668002390	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668002391	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1097668002392	disulfide bond formation protein B; Provisional; Region: PRK02110
1097668002393	amidase; Provisional; Region: PRK07056
1097668002394	Amidase; Region: Amidase; cl11426
1097668002395	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1097668002396	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668002397	FeS/SAM binding site; other site
1097668002398	HemN C-terminal domain; Region: HemN_C; pfam06969
1097668002399	Flagellin N-methylase; Region: FliB; pfam03692
1097668002400	Protein of unknown function (DUF1439); Region: DUF1439; cl06345
1097668002401	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1097668002402	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668002403	S-adenosylmethionine binding site [chemical binding]; other site
1097668002404	YGGT family; Region: YGGT; pfam02325
1097668002405	YGGT family; Region: YGGT; pfam02325
1097668002406	serine racemase; Region: PLN02970
1097668002407	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1097668002408	tetramer interface [polypeptide binding]; other site
1097668002409	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668002410	catalytic residue [active]
1097668002411	LysE type translocator; Region: LysE; cl00565
1097668002412	L-asparaginase II; Region: Asparaginase_II; pfam06089
1097668002413	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1097668002414	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1097668002415	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668002416	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668002417	catalytic residue [active]
1097668002418	aminotransferase; Validated; Region: PRK07337
1097668002419	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668002420	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668002421	homodimer interface [polypeptide binding]; other site
1097668002422	catalytic residue [active]
1097668002423	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1097668002424	putative RNA binding site [nucleotide binding]; other site
1097668002425	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1097668002426	homopentamer interface [polypeptide binding]; other site
1097668002427	active site
1097668002428	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1097668002429	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1097668002430	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1097668002431	dimerization interface [polypeptide binding]; other site
1097668002432	active site
1097668002433	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1097668002434	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1097668002435	Lumazine binding domain; Region: Lum_binding; pfam00677
1097668002436	Lumazine binding domain; Region: Lum_binding; pfam00677
1097668002437	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1097668002438	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1097668002439	catalytic motif [active]
1097668002440	Zn binding site [ion binding]; other site
1097668002441	RibD C-terminal domain; Region: RibD_C; cl17279
1097668002442	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1097668002443	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668002444	inhibitor-cofactor binding pocket; inhibition site
1097668002445	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668002446	catalytic residue [active]
1097668002447	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1097668002448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668002449	putative substrate translocation pore; other site
1097668002450	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1097668002451	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668002452	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1097668002453	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1097668002454	Walker A/P-loop; other site
1097668002455	ATP binding site [chemical binding]; other site
1097668002456	Q-loop/lid; other site
1097668002457	ABC transporter signature motif; other site
1097668002458	Walker B; other site
1097668002459	D-loop; other site
1097668002460	H-loop/switch region; other site
1097668002461	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097668002462	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668002463	dimer interface [polypeptide binding]; other site
1097668002464	conserved gate region; other site
1097668002465	putative PBP binding loops; other site
1097668002466	ABC-ATPase subunit interface; other site
1097668002467	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668002468	dimer interface [polypeptide binding]; other site
1097668002469	conserved gate region; other site
1097668002470	putative PBP binding loops; other site
1097668002471	ABC-ATPase subunit interface; other site
1097668002472	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097668002473	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097668002474	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1097668002475	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1097668002476	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1097668002477	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1097668002478	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1097668002479	putative active site [active]
1097668002480	bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101
1097668002481	glucokinase; Provisional; Region: glk; PRK00292
1097668002482	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097668002483	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097668002484	putative active site [active]
1097668002485	Esterase/lipase [General function prediction only]; Region: COG1647
1097668002486	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668002487	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668002488	trimer interface [polypeptide binding]; other site
1097668002489	eyelet of channel; other site
1097668002490	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668002491	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668002492	trimer interface [polypeptide binding]; other site
1097668002493	eyelet of channel; other site
1097668002494	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1097668002495	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668002496	Walker A/P-loop; other site
1097668002497	ATP binding site [chemical binding]; other site
1097668002498	Q-loop/lid; other site
1097668002499	ABC transporter signature motif; other site
1097668002500	Walker B; other site
1097668002501	D-loop; other site
1097668002502	H-loop/switch region; other site
1097668002503	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668002504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668002505	dimer interface [polypeptide binding]; other site
1097668002506	conserved gate region; other site
1097668002507	putative PBP binding loops; other site
1097668002508	ABC-ATPase subunit interface; other site
1097668002509	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668002510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668002511	dimer interface [polypeptide binding]; other site
1097668002512	conserved gate region; other site
1097668002513	putative PBP binding loops; other site
1097668002514	ABC-ATPase subunit interface; other site
1097668002515	Pirin-related protein [General function prediction only]; Region: COG1741
1097668002516	Pirin; Region: Pirin; pfam02678
1097668002517	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
1097668002518	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668002519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668002520	active site
1097668002521	phosphorylation site [posttranslational modification]
1097668002522	intermolecular recognition site; other site
1097668002523	dimerization interface [polypeptide binding]; other site
1097668002524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668002525	DNA binding site [nucleotide binding]
1097668002526	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668002527	dimerization interface [polypeptide binding]; other site
1097668002528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1097668002529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668002530	dimer interface [polypeptide binding]; other site
1097668002531	phosphorylation site [posttranslational modification]
1097668002532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668002533	ATP binding site [chemical binding]; other site
1097668002534	Mg2+ binding site [ion binding]; other site
1097668002535	G-X-G motif; other site
1097668002536	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1097668002537	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668002538	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668002539	metal binding site [ion binding]; metal-binding site
1097668002540	active site
1097668002541	I-site; other site
1097668002542	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
1097668002543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668002544	dimer interface [polypeptide binding]; other site
1097668002545	conserved gate region; other site
1097668002546	putative PBP binding loops; other site
1097668002547	ABC-ATPase subunit interface; other site
1097668002548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668002549	dimer interface [polypeptide binding]; other site
1097668002550	conserved gate region; other site
1097668002551	putative PBP binding loops; other site
1097668002552	ABC-ATPase subunit interface; other site
1097668002553	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668002554	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668002555	Walker A/P-loop; other site
1097668002556	ATP binding site [chemical binding]; other site
1097668002557	Q-loop/lid; other site
1097668002558	ABC transporter signature motif; other site
1097668002559	Walker B; other site
1097668002560	D-loop; other site
1097668002561	H-loop/switch region; other site
1097668002562	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
1097668002563	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
1097668002564	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1097668002565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668002566	Walker A motif; other site
1097668002567	ATP binding site [chemical binding]; other site
1097668002568	Walker B motif; other site
1097668002569	arginine finger; other site
1097668002570	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668002571	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1097668002572	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1097668002573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668002574	active site
1097668002575	phosphorylation site [posttranslational modification]
1097668002576	intermolecular recognition site; other site
1097668002577	dimerization interface [polypeptide binding]; other site
1097668002578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668002579	Walker A motif; other site
1097668002580	ATP binding site [chemical binding]; other site
1097668002581	Walker B motif; other site
1097668002582	arginine finger; other site
1097668002583	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668002584	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1097668002585	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1097668002586	active site
1097668002587	homotetramer interface [polypeptide binding]; other site
1097668002588	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1097668002589	RNA polymerase factor sigma-54; Provisional; Region: PRK12469
1097668002590	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1097668002591	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1097668002592	BON domain; Region: BON; pfam04972
1097668002593	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
1097668002594	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1097668002595	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1097668002596	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1097668002597	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1097668002598	proposed catalytic triad [active]
1097668002599	conserved cys residue [active]
1097668002600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668002601	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668002602	putative substrate translocation pore; other site
1097668002603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668002604	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1097668002605	substrate binding site [chemical binding]; other site
1097668002606	PAS domain; Region: PAS_9; pfam13426
1097668002607	PAS domain; Region: PAS_9; pfam13426
1097668002608	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668002609	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668002610	metal binding site [ion binding]; metal-binding site
1097668002611	active site
1097668002612	I-site; other site
1097668002613	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668002614	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668002615	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
1097668002616	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668002617	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668002618	shikimate binding site; other site
1097668002619	NAD(P) binding site [chemical binding]; other site
1097668002620	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1097668002621	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1097668002622	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1097668002623	dimer interface [polypeptide binding]; other site
1097668002624	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1097668002625	active site
1097668002626	Fe binding site [ion binding]; other site
1097668002627	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668002628	cyanate hydratase; Validated; Region: PRK02866
1097668002629	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
1097668002630	oligomer interface [polypeptide binding]; other site
1097668002631	active site
1097668002632	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1097668002633	active site clefts [active]
1097668002634	zinc binding site [ion binding]; other site
1097668002635	dimer interface [polypeptide binding]; other site
1097668002636	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1097668002637	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668002638	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
1097668002639	dimerization interface [polypeptide binding]; other site
1097668002640	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
1097668002641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668002642	S-adenosylmethionine binding site [chemical binding]; other site
1097668002643	Rubredoxin [Energy production and conversion]; Region: COG1773
1097668002644	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1097668002645	iron binding site [ion binding]; other site
1097668002646	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1097668002647	ABC transporter ATPase component; Reviewed; Region: PRK11147
1097668002648	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668002649	Walker A/P-loop; other site
1097668002650	ATP binding site [chemical binding]; other site
1097668002651	Q-loop/lid; other site
1097668002652	ABC transporter signature motif; other site
1097668002653	Walker B; other site
1097668002654	D-loop; other site
1097668002655	H-loop/switch region; other site
1097668002656	ABC transporter; Region: ABC_tran_2; pfam12848
1097668002657	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668002658	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1097668002659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668002660	ATP binding site [chemical binding]; other site
1097668002661	Mg2+ binding site [ion binding]; other site
1097668002662	G-X-G motif; other site
1097668002663	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1097668002664	anchoring element; other site
1097668002665	dimer interface [polypeptide binding]; other site
1097668002666	ATP binding site [chemical binding]; other site
1097668002667	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1097668002668	active site
1097668002669	metal binding site [ion binding]; metal-binding site
1097668002670	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1097668002671	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1097668002672	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1097668002673	CAP-like domain; other site
1097668002674	active site
1097668002675	primary dimer interface [polypeptide binding]; other site
1097668002676	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668002677	non-specific DNA binding site [nucleotide binding]; other site
1097668002678	salt bridge; other site
1097668002679	sequence-specific DNA binding site [nucleotide binding]; other site
1097668002680	Predicted integral membrane protein [Function unknown]; Region: COG5615
1097668002681	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668002682	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668002683	metal binding site [ion binding]; metal-binding site
1097668002684	active site
1097668002685	I-site; other site
1097668002686	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668002687	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1097668002688	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668002689	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1097668002690	homotrimer interaction site [polypeptide binding]; other site
1097668002691	putative active site [active]
1097668002692	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1097668002693	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668002694	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668002695	homodimer interface [polypeptide binding]; other site
1097668002696	catalytic residue [active]
1097668002697	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097668002698	EamA-like transporter family; Region: EamA; pfam00892
1097668002699	EamA-like transporter family; Region: EamA; pfam00892
1097668002700	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1097668002701	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668002702	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668002703	DNA-binding site [nucleotide binding]; DNA binding site
1097668002704	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668002705	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668002706	homodimer interface [polypeptide binding]; other site
1097668002707	catalytic residue [active]
1097668002708	heat shock protein 90; Provisional; Region: PRK05218
1097668002709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668002710	ATP binding site [chemical binding]; other site
1097668002711	Mg2+ binding site [ion binding]; other site
1097668002712	G-X-G motif; other site
1097668002713	Chorismate lyase; Region: Chor_lyase; cl01230
1097668002714	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
1097668002715	putative active site [active]
1097668002716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668002717	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
1097668002718	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1097668002719	Na binding site [ion binding]; other site
1097668002720	Predicted membrane protein [Function unknown]; Region: COG1289
1097668002721	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668002722	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668002723	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1097668002724	dimer interface [polypeptide binding]; other site
1097668002725	transaldolase-like protein; Provisional; Region: PTZ00411
1097668002726	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1097668002727	active site
1097668002728	dimer interface [polypeptide binding]; other site
1097668002729	catalytic residue [active]
1097668002730	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1097668002731	benzoate transporter; Region: benE; TIGR00843
1097668002732	Benzoate membrane transport protein; Region: BenE; pfam03594
1097668002733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1097668002734	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097668002735	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1097668002736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668002737	Walker A motif; other site
1097668002738	ATP binding site [chemical binding]; other site
1097668002739	Walker B motif; other site
1097668002740	arginine finger; other site
1097668002741	Cytochrome c; Region: Cytochrom_C; cl11414
1097668002742	Cytochrome c; Region: Cytochrom_C; cl11414
1097668002743	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668002744	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
1097668002745	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1097668002746	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1097668002747	minor groove reading motif; other site
1097668002748	helix-hairpin-helix signature motif; other site
1097668002749	substrate binding pocket [chemical binding]; other site
1097668002750	active site
1097668002751	ferredoxin; Provisional; Region: PRK06991
1097668002752	Putative Fe-S cluster; Region: FeS; pfam04060
1097668002753	4Fe-4S binding domain; Region: Fer4; pfam00037
1097668002754	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668002755	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668002756	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
1097668002757	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1097668002758	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1097668002759	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1097668002760	Protein of unknown function (DUF3096); Region: DUF3096; pfam11295
1097668002761	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1097668002762	Antimicrobial peptide resistance and lipid A acylation protein PagP; Region: PagP; cl06181
1097668002763	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1097668002764	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
1097668002765	Cl binding site [ion binding]; other site
1097668002766	oligomer interface [polypeptide binding]; other site
1097668002767	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1097668002768	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1097668002769	META domain; Region: META; pfam03724
1097668002770	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1097668002771	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668002772	ATP-grasp domain; Region: ATP-grasp; pfam02222
1097668002773	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1097668002774	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1097668002775	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097668002776	ATP binding site [chemical binding]; other site
1097668002777	Mg++ binding site [ion binding]; other site
1097668002778	motif III; other site
1097668002779	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668002780	nucleotide binding region [chemical binding]; other site
1097668002781	ATP-binding site [chemical binding]; other site
1097668002782	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
1097668002783	active site
1097668002784	HIGH motif; other site
1097668002785	nucleotide binding site [chemical binding]; other site
1097668002786	active site
1097668002787	KMSKS motif; other site
1097668002788	rhodanese superfamily protein; Provisional; Region: PRK05320
1097668002789	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1097668002790	active site residue [active]
1097668002791	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1097668002792	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1097668002793	putative active site [active]
1097668002794	putative PHP Thumb interface [polypeptide binding]; other site
1097668002795	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1097668002796	generic binding surface II; other site
1097668002797	generic binding surface I; other site
1097668002798	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097668002799	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1097668002800	putative metal binding site; other site
1097668002801	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1097668002802	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097668002803	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1097668002804	Walker A/P-loop; other site
1097668002805	ATP binding site [chemical binding]; other site
1097668002806	Q-loop/lid; other site
1097668002807	ABC transporter signature motif; other site
1097668002808	Walker B; other site
1097668002809	D-loop; other site
1097668002810	H-loop/switch region; other site
1097668002811	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1097668002812	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668002813	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1097668002814	O-Antigen ligase; Region: Wzy_C; pfam04932
1097668002815	ribonuclease G; Provisional; Region: PRK11712
1097668002816	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1097668002817	homodimer interface [polypeptide binding]; other site
1097668002818	oligonucleotide binding site [chemical binding]; other site
1097668002819	Maf-like protein; Region: Maf; pfam02545
1097668002820	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1097668002821	active site
1097668002822	dimer interface [polypeptide binding]; other site
1097668002823	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1097668002824	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1097668002825	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1097668002826	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1097668002827	active site
1097668002828	(T/H)XGH motif; other site
1097668002829	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1097668002830	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1097668002831	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1097668002832	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1097668002833	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1097668002834	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1097668002835	hypothetical protein; Validated; Region: PRK00110
1097668002836	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668002837	active site
1097668002838	short chain dehydrogenase; Provisional; Region: PRK08339
1097668002839	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1097668002840	putative NAD(P) binding site [chemical binding]; other site
1097668002841	putative active site [active]
1097668002842	methylglyoxal synthase; Validated; Region: mgsA; PRK05234
1097668002843	substrate binding site [chemical binding]; other site
1097668002844	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1097668002845	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1097668002846	NADP binding site [chemical binding]; other site
1097668002847	dimer interface [polypeptide binding]; other site
1097668002848	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1097668002849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668002850	active site
1097668002851	phosphorylation site [posttranslational modification]
1097668002852	intermolecular recognition site; other site
1097668002853	dimerization interface [polypeptide binding]; other site
1097668002854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668002855	DNA binding site [nucleotide binding]
1097668002856	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1097668002857	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1097668002858	NAD(P) binding site [chemical binding]; other site
1097668002859	putative active site [active]
1097668002860	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
1097668002861	Protein export membrane protein; Region: SecD_SecF; cl14618
1097668002862	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
1097668002863	Protein export membrane protein; Region: SecD_SecF; cl14618
1097668002864	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668002865	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668002866	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668002867	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668002868	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668002869	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668002870	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668002871	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668002872	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1097668002873	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668002874	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668002875	putative DNA binding site [nucleotide binding]; other site
1097668002876	putative Zn2+ binding site [ion binding]; other site
1097668002877	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668002878	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1097668002879	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668002880	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1097668002881	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
1097668002882	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1097668002883	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
1097668002884	Family description; Region: UvrD_C_2; pfam13538
1097668002885	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1097668002886	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
1097668002887	AAA domain; Region: AAA_30; pfam13604
1097668002888	Family description; Region: UvrD_C_2; pfam13538
1097668002889	hypothetical protein; Provisional; Region: PRK09256
1097668002890	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1097668002891	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1097668002892	EamA-like transporter family; Region: EamA; pfam00892
1097668002893	EamA-like transporter family; Region: EamA; pfam00892
1097668002894	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1097668002895	L-lactate permease; Region: Lactate_perm; cl00701
1097668002896	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1097668002897	ThiC-associated domain; Region: ThiC-associated; pfam13667
1097668002898	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1097668002899	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1097668002900	EamA-like transporter family; Region: EamA; pfam00892
1097668002901	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
1097668002902	Predicted small secreted protein [Function unknown]; Region: COG5510
1097668002903	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668002904	Histidine kinase; Region: HisKA_3; pfam07730
1097668002905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668002906	ATP binding site [chemical binding]; other site
1097668002907	Mg2+ binding site [ion binding]; other site
1097668002908	G-X-G motif; other site
1097668002909	Ferritin-like domain; Region: Ferritin; pfam00210
1097668002910	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1097668002911	dinuclear metal binding motif [ion binding]; other site
1097668002912	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668002913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668002914	active site
1097668002915	phosphorylation site [posttranslational modification]
1097668002916	intermolecular recognition site; other site
1097668002917	dimerization interface [polypeptide binding]; other site
1097668002918	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668002919	DNA binding residues [nucleotide binding]
1097668002920	dimerization interface [polypeptide binding]; other site
1097668002921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668002922	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668002923	active site
1097668002924	phosphorylation site [posttranslational modification]
1097668002925	intermolecular recognition site; other site
1097668002926	dimerization interface [polypeptide binding]; other site
1097668002927	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1097668002928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668002929	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1097668002930	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097668002931	active site
1097668002932	metal binding site [ion binding]; metal-binding site
1097668002933	hexamer interface [polypeptide binding]; other site
1097668002934	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1097668002935	active site
1097668002936	metal binding site [ion binding]; metal-binding site
1097668002937	homotetramer interface [polypeptide binding]; other site
1097668002938	proline/glycine betaine transporter; Provisional; Region: PRK10642
1097668002939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668002940	putative substrate translocation pore; other site
1097668002941	oxidative damage protection protein; Provisional; Region: PRK05408
1097668002942	N-acetylglutamate synthase; Validated; Region: PRK05279
1097668002943	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1097668002944	putative feedback inhibition sensing region; other site
1097668002945	putative nucleotide binding site [chemical binding]; other site
1097668002946	putative substrate binding site [chemical binding]; other site
1097668002947	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668002948	Coenzyme A binding pocket [chemical binding]; other site
1097668002949	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
1097668002950	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668002951	ATP binding site [chemical binding]; other site
1097668002952	putative Mg++ binding site [ion binding]; other site
1097668002953	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668002954	nucleotide binding region [chemical binding]; other site
1097668002955	ATP-binding site [chemical binding]; other site
1097668002956	Helicase associated domain (HA2); Region: HA2; pfam04408
1097668002957	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1097668002958	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1097668002959	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1097668002960	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1097668002961	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1097668002962	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1097668002963	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
1097668002964	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1097668002965	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1097668002966	putative MPT binding site; other site
1097668002967	CutC family; Region: CutC; cl01218
1097668002968	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1097668002969	active site residue [active]
1097668002970	glutamine synthetase; Provisional; Region: glnA; PRK09469
1097668002971	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1097668002972	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1097668002973	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1097668002974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668002975	putative active site [active]
1097668002976	heme pocket [chemical binding]; other site
1097668002977	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668002978	dimer interface [polypeptide binding]; other site
1097668002979	phosphorylation site [posttranslational modification]
1097668002980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668002981	ATP binding site [chemical binding]; other site
1097668002982	Mg2+ binding site [ion binding]; other site
1097668002983	G-X-G motif; other site
1097668002984	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1097668002985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668002986	active site
1097668002987	phosphorylation site [posttranslational modification]
1097668002988	intermolecular recognition site; other site
1097668002989	dimerization interface [polypeptide binding]; other site
1097668002990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668002991	Walker A motif; other site
1097668002992	ATP binding site [chemical binding]; other site
1097668002993	Walker B motif; other site
1097668002994	arginine finger; other site
1097668002995	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668002996	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1097668002997	putative catalytic site [active]
1097668002998	putative phosphate binding site [ion binding]; other site
1097668002999	active site
1097668003000	metal binding site A [ion binding]; metal-binding site
1097668003001	DNA binding site [nucleotide binding]
1097668003002	putative AP binding site [nucleotide binding]; other site
1097668003003	putative metal binding site B [ion binding]; other site
1097668003004	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1097668003005	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1097668003006	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097668003007	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
1097668003008	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1097668003009	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1097668003010	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1097668003011	Ligand Binding Site [chemical binding]; other site
1097668003012	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1097668003013	GAF domain; Region: GAF_3; pfam13492
1097668003014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668003015	dimer interface [polypeptide binding]; other site
1097668003016	phosphorylation site [posttranslational modification]
1097668003017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668003018	ATP binding site [chemical binding]; other site
1097668003019	Mg2+ binding site [ion binding]; other site
1097668003020	G-X-G motif; other site
1097668003021	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097668003022	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097668003023	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1097668003024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003025	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1097668003026	dimerization interface [polypeptide binding]; other site
1097668003027	substrate binding pocket [chemical binding]; other site
1097668003028	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1097668003029	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1097668003030	active site
1097668003031	catalytic triad [active]
1097668003032	dimer interface [polypeptide binding]; other site
1097668003033	cytosine deaminase; Validated; Region: PRK07572
1097668003034	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1097668003035	active site
1097668003036	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1097668003037	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1097668003038	active site
1097668003039	Zn binding site [ion binding]; other site
1097668003040	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189
1097668003041	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1097668003042	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1097668003043	homodimer interface [polypeptide binding]; other site
1097668003044	NADP binding site [chemical binding]; other site
1097668003045	substrate binding site [chemical binding]; other site
1097668003046	Protein of unknown function (DUF2950); Region: DUF2950; pfam11453
1097668003047	Protein of unknown function (DUF3300); Region: DUF3300; pfam11737
1097668003048	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1097668003049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668003050	active site
1097668003051	phosphorylation site [posttranslational modification]
1097668003052	intermolecular recognition site; other site
1097668003053	dimerization interface [polypeptide binding]; other site
1097668003054	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668003055	DNA binding residues [nucleotide binding]
1097668003056	dimerization interface [polypeptide binding]; other site
1097668003057	PAS domain S-box; Region: sensory_box; TIGR00229
1097668003058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668003059	putative active site [active]
1097668003060	heme pocket [chemical binding]; other site
1097668003061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668003062	dimer interface [polypeptide binding]; other site
1097668003063	phosphorylation site [posttranslational modification]
1097668003064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668003065	ATP binding site [chemical binding]; other site
1097668003066	Mg2+ binding site [ion binding]; other site
1097668003067	G-X-G motif; other site
1097668003068	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1097668003069	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1097668003070	dimer interface [polypeptide binding]; other site
1097668003071	TPP-binding site [chemical binding]; other site
1097668003072	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
1097668003073	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
1097668003074	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668003075	E3 interaction surface; other site
1097668003076	lipoyl attachment site [posttranslational modification]; other site
1097668003077	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668003078	E3 interaction surface; other site
1097668003079	lipoyl attachment site [posttranslational modification]; other site
1097668003080	e3 binding domain; Region: E3_binding; pfam02817
1097668003081	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1097668003082	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668003083	E3 interaction surface; other site
1097668003084	lipoyl attachment site [posttranslational modification]; other site
1097668003085	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668003086	E3 interaction surface; other site
1097668003087	lipoyl attachment site [posttranslational modification]; other site
1097668003088	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1097668003089	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668003090	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668003091	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668003092	Phasin protein; Region: Phasin_2; pfam09361
1097668003093	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1097668003094	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1097668003095	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668003096	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668003097	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668003098	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1097668003099	Cysteine-rich domain; Region: CCG; pfam02754
1097668003100	Cysteine-rich domain; Region: CCG; pfam02754
1097668003101	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1097668003102	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1097668003103	4Fe-4S binding domain; Region: Fer4; pfam00037
1097668003104	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1097668003105	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1097668003106	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668003107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003108	homodimer interface [polypeptide binding]; other site
1097668003109	catalytic residue [active]
1097668003110	excinuclease ABC subunit B; Provisional; Region: PRK05298
1097668003111	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668003112	ATP binding site [chemical binding]; other site
1097668003113	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668003114	nucleotide binding region [chemical binding]; other site
1097668003115	ATP-binding site [chemical binding]; other site
1097668003116	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1097668003117	UvrB/uvrC motif; Region: UVR; pfam02151
1097668003118	Fe2+ transport protein; Region: Iron_transport; pfam10634
1097668003119	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1097668003120	Iron permease FTR1 family; Region: FTR1; cl00475
1097668003121	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
1097668003122	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1097668003123	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
1097668003124	Hemin uptake protein hemP; Region: hemP; pfam10636
1097668003125	DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863
1097668003126	putative hydrophobic ligand binding site [chemical binding]; other site
1097668003127	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1097668003128	Pirin-related protein [General function prediction only]; Region: COG1741
1097668003129	Pirin; Region: Pirin; pfam02678
1097668003130	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1097668003131	LysR family transcriptional regulator; Provisional; Region: PRK14997
1097668003132	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003133	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1097668003134	putative effector binding pocket; other site
1097668003135	putative dimerization interface [polypeptide binding]; other site
1097668003136	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1097668003137	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1097668003138	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1097668003139	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1097668003140	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1097668003141	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1097668003142	glutamate racemase; Provisional; Region: PRK00865
1097668003143	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1097668003144	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1097668003145	heme binding site [chemical binding]; other site
1097668003146	ferroxidase pore; other site
1097668003147	ferroxidase diiron center [ion binding]; other site
1097668003148	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1097668003149	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1097668003150	hypothetical protein; Provisional; Region: PRK05208
1097668003151	EamA-like transporter family; Region: EamA; pfam00892
1097668003152	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1097668003153	EamA-like transporter family; Region: EamA; pfam00892
1097668003154	acetyl-CoA synthetase; Provisional; Region: PRK00174
1097668003155	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1097668003156	active site
1097668003157	CoA binding site [chemical binding]; other site
1097668003158	acyl-activating enzyme (AAE) consensus motif; other site
1097668003159	AMP binding site [chemical binding]; other site
1097668003160	acetate binding site [chemical binding]; other site
1097668003161	Domain of unknown function (DUF4212); Region: DUF4212; cl01781
1097668003162	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1097668003163	probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648
1097668003164	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1097668003165	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1097668003166	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668003167	active site
1097668003168	Int/Topo IB signature motif; other site
1097668003169	DNA binding site [nucleotide binding]
1097668003170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1097668003171	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668003172	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668003173	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1097668003174	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1097668003175	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1097668003176	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1097668003177	PRC-barrel domain; Region: PRC; pfam05239
1097668003178	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
1097668003179	RNA/DNA hybrid binding site [nucleotide binding]; other site
1097668003180	active site
1097668003181	short chain dehydrogenase; Provisional; Region: PRK07023
1097668003182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668003183	NAD(P) binding site [chemical binding]; other site
1097668003184	active site
1097668003185	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668003186	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668003187	trimer interface [polypeptide binding]; other site
1097668003188	eyelet of channel; other site
1097668003189	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668003190	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1097668003191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668003192	putative substrate translocation pore; other site
1097668003193	POT family; Region: PTR2; cl17359
1097668003194	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1097668003195	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668003196	catalytic loop [active]
1097668003197	iron binding site [ion binding]; other site
1097668003198	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1097668003199	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1097668003200	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1097668003201	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1097668003202	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097668003203	Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943
1097668003204	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1097668003205	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668003206	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668003207	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003208	dimer interface [polypeptide binding]; other site
1097668003209	conserved gate region; other site
1097668003210	putative PBP binding loops; other site
1097668003211	ABC-ATPase subunit interface; other site
1097668003212	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668003213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003214	dimer interface [polypeptide binding]; other site
1097668003215	conserved gate region; other site
1097668003216	putative PBP binding loops; other site
1097668003217	ABC-ATPase subunit interface; other site
1097668003218	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1097668003219	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668003220	Walker A/P-loop; other site
1097668003221	ATP binding site [chemical binding]; other site
1097668003222	Q-loop/lid; other site
1097668003223	ABC transporter signature motif; other site
1097668003224	Walker B; other site
1097668003225	D-loop; other site
1097668003226	H-loop/switch region; other site
1097668003227	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668003228	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668003229	conserved cys residue [active]
1097668003230	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668003231	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668003232	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1097668003233	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668003234	inhibitor-cofactor binding pocket; inhibition site
1097668003235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003236	catalytic residue [active]
1097668003237	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1097668003238	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1097668003239	Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440
1097668003240	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1097668003241	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1097668003242	NAD(P) binding site [chemical binding]; other site
1097668003243	catalytic residues [active]
1097668003244	succinylarginine dihydrolase; Provisional; Region: PRK13281
1097668003245	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
1097668003246	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1097668003247	putative active site [active]
1097668003248	Zn binding site [ion binding]; other site
1097668003249	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1097668003250	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668003251	substrate binding pocket [chemical binding]; other site
1097668003252	membrane-bound complex binding site; other site
1097668003253	hinge residues; other site
1097668003254	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1097668003255	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668003256	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668003257	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1097668003258	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1097668003259	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668003260	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668003261	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668003262	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003263	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668003264	putative effector binding pocket; other site
1097668003265	dimerization interface [polypeptide binding]; other site
1097668003266	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
1097668003267	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097668003268	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
1097668003269	putative active site [active]
1097668003270	putative metal binding site [ion binding]; other site
1097668003271	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668003272	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668003273	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
1097668003274	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1097668003275	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668003276	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
1097668003277	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1097668003278	Protein of unknown function (DUF962); Region: DUF962; cl01879
1097668003279	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668003280	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668003281	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134
1097668003282	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1097668003283	homodimer interface [polypeptide binding]; other site
1097668003284	substrate-cofactor binding pocket; other site
1097668003285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003286	catalytic residue [active]
1097668003287	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668003288	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625
1097668003289	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668003290	putative substrate translocation pore; other site
1097668003291	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097668003292	putative acyl-acceptor binding pocket; other site
1097668003293	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1097668003294	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1097668003295	Tetramer interface [polypeptide binding]; other site
1097668003296	active site
1097668003297	FMN-binding site [chemical binding]; other site
1097668003298	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1097668003299	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668003300	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1097668003301	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
1097668003302	short chain dehydrogenase; Provisional; Region: PRK06949
1097668003303	classical (c) SDRs; Region: SDR_c; cd05233
1097668003304	NAD(P) binding site [chemical binding]; other site
1097668003305	active site
1097668003306	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097668003307	active site
1097668003308	PAS domain; Region: PAS_9; pfam13426
1097668003309	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668003310	putative active site [active]
1097668003311	heme pocket [chemical binding]; other site
1097668003312	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668003313	DNA binding residues [nucleotide binding]
1097668003314	dimerization interface [polypeptide binding]; other site
1097668003315	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1097668003316	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1097668003317	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668003318	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668003319	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1097668003320	homotrimer interaction site [polypeptide binding]; other site
1097668003321	putative active site [active]
1097668003322	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1097668003323	HD domain; Region: HD_4; pfam13328
1097668003324	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1097668003325	synthetase active site [active]
1097668003326	NTP binding site [chemical binding]; other site
1097668003327	metal binding site [ion binding]; metal-binding site
1097668003328	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1097668003329	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1097668003330	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1097668003331	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1097668003332	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1097668003333	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1097668003334	active site
1097668003335	dimer interface [polypeptide binding]; other site
1097668003336	motif 1; other site
1097668003337	motif 2; other site
1097668003338	motif 3; other site
1097668003339	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1097668003340	anticodon binding site; other site
1097668003341	translation initiation factor IF-3; Region: infC; TIGR00168
1097668003342	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1097668003343	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1097668003344	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1097668003345	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1097668003346	23S rRNA binding site [nucleotide binding]; other site
1097668003347	L21 binding site [polypeptide binding]; other site
1097668003348	L13 binding site [polypeptide binding]; other site
1097668003349	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1097668003350	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1097668003351	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1097668003352	dimer interface [polypeptide binding]; other site
1097668003353	motif 1; other site
1097668003354	active site
1097668003355	motif 2; other site
1097668003356	motif 3; other site
1097668003357	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1097668003358	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1097668003359	putative tRNA-binding site [nucleotide binding]; other site
1097668003360	B3/4 domain; Region: B3_4; pfam03483
1097668003361	tRNA synthetase B5 domain; Region: B5; smart00874
1097668003362	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1097668003363	dimer interface [polypeptide binding]; other site
1097668003364	motif 1; other site
1097668003365	motif 3; other site
1097668003366	motif 2; other site
1097668003367	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1097668003368	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097668003369	IHF dimer interface [polypeptide binding]; other site
1097668003370	IHF - DNA interface [nucleotide binding]; other site
1097668003371	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1097668003372	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097668003373	DNA binding residues [nucleotide binding]
1097668003374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668003375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003376	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668003377	putative effector binding pocket; other site
1097668003378	dimerization interface [polypeptide binding]; other site
1097668003379	Predicted membrane protein [Function unknown]; Region: COG2259
1097668003380	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668003381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003382	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668003383	substrate binding pocket [chemical binding]; other site
1097668003384	dimerization interface [polypeptide binding]; other site
1097668003385	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1097668003386	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668003387	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668003388	3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429
1097668003389	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1097668003390	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1097668003391	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668003392	dimer interface [polypeptide binding]; other site
1097668003393	active site
1097668003394	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053
1097668003395	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1097668003396	tetramer interface [polypeptide binding]; other site
1097668003397	active site
1097668003398	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1097668003399	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1097668003400	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
1097668003401	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
1097668003402	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
1097668003403	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1097668003404	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1097668003405	malate synthase A; Region: malate_syn_A; TIGR01344
1097668003406	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1097668003407	active site
1097668003408	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1097668003409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668003410	motif II; other site
1097668003411	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668003413	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668003414	putative effector binding pocket; other site
1097668003415	dimerization interface [polypeptide binding]; other site
1097668003416	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668003417	Ligand Binding Site [chemical binding]; other site
1097668003418	isocitrate lyase; Provisional; Region: PRK15063
1097668003419	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668003420	tetramer interface [polypeptide binding]; other site
1097668003421	active site
1097668003422	Mg2+/Mn2+ binding site [ion binding]; other site
1097668003423	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097668003424	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1097668003425	ATP binding site [chemical binding]; other site
1097668003426	Mg++ binding site [ion binding]; other site
1097668003427	motif III; other site
1097668003428	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668003429	nucleotide binding region [chemical binding]; other site
1097668003430	ATP-binding site [chemical binding]; other site
1097668003431	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
1097668003432	acyl-CoA binding pocket [chemical binding]; other site
1097668003433	CoA binding site [chemical binding]; other site
1097668003434	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1097668003435	Glycoprotease family; Region: Peptidase_M22; pfam00814
1097668003436	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1097668003437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668003438	Coenzyme A binding pocket [chemical binding]; other site
1097668003439	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1097668003440	Fe-S cluster binding site [ion binding]; other site
1097668003441	active site
1097668003442	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
1097668003443	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1097668003444	dimer interface [polypeptide binding]; other site
1097668003445	substrate binding site [chemical binding]; other site
1097668003446	ATP binding site [chemical binding]; other site
1097668003447	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1097668003448	thiamine phosphate binding site [chemical binding]; other site
1097668003449	active site
1097668003450	pyrophosphate binding site [ion binding]; other site
1097668003451	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1097668003452	substrate binding site [chemical binding]; other site
1097668003453	multimerization interface [polypeptide binding]; other site
1097668003454	ATP binding site [chemical binding]; other site
1097668003455	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1097668003456	alanine racemase; Reviewed; Region: dadX; PRK03646
1097668003457	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1097668003458	active site
1097668003459	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668003460	substrate binding site [chemical binding]; other site
1097668003461	catalytic residues [active]
1097668003462	dimer interface [polypeptide binding]; other site
1097668003463	DNA repair protein RadA; Provisional; Region: PRK11823
1097668003464	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668003465	Walker A motif; other site
1097668003466	ATP binding site [chemical binding]; other site
1097668003467	Walker B motif; other site
1097668003468	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1097668003469	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
1097668003470	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668003471	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668003472	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1097668003473	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668003474	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668003475	ABC transporter; Region: ABC_tran_2; pfam12848
1097668003476	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668003477	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1097668003478	catalytic residues [active]
1097668003479	dimer interface [polypeptide binding]; other site
1097668003480	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1097668003481	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
1097668003482	putative active site [active]
1097668003483	catalytic site [active]
1097668003484	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
1097668003485	putative active site [active]
1097668003486	catalytic site [active]
1097668003487	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1097668003488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668003489	S-adenosylmethionine binding site [chemical binding]; other site
1097668003490	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1097668003491	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1097668003492	metal binding site [ion binding]; metal-binding site
1097668003493	dimer interface [polypeptide binding]; other site
1097668003494	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1097668003495	ArsC family; Region: ArsC; pfam03960
1097668003496	putative catalytic residues [active]
1097668003497	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1097668003498	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1097668003499	trimer interface [polypeptide binding]; other site
1097668003500	active site
1097668003501	substrate binding site [chemical binding]; other site
1097668003502	CoA binding site [chemical binding]; other site
1097668003503	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
1097668003504	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668003505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003506	homodimer interface [polypeptide binding]; other site
1097668003507	catalytic residue [active]
1097668003508	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097668003509	EamA-like transporter family; Region: EamA; pfam00892
1097668003510	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1097668003511	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1097668003512	Walker A/P-loop; other site
1097668003513	ATP binding site [chemical binding]; other site
1097668003514	Q-loop/lid; other site
1097668003515	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1097668003516	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1097668003517	Q-loop/lid; other site
1097668003518	ABC transporter signature motif; other site
1097668003519	Walker B; other site
1097668003520	D-loop; other site
1097668003521	H-loop/switch region; other site
1097668003522	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
1097668003523	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1097668003524	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1097668003525	nucleotide binding pocket [chemical binding]; other site
1097668003526	K-X-D-G motif; other site
1097668003527	catalytic site [active]
1097668003528	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1097668003529	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1097668003530	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1097668003531	Dimer interface [polypeptide binding]; other site
1097668003532	BRCT sequence motif; other site
1097668003533	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1097668003534	active site
1097668003535	catalytic residues [active]
1097668003536	metal binding site [ion binding]; metal-binding site
1097668003537	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1097668003538	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668003539	RNA binding surface [nucleotide binding]; other site
1097668003540	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1097668003541	active site
1097668003542	PII uridylyl-transferase; Provisional; Region: PRK03059
1097668003543	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1097668003544	metal binding triad; other site
1097668003545	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1097668003546	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097668003547	Zn2+ binding site [ion binding]; other site
1097668003548	Mg2+ binding site [ion binding]; other site
1097668003549	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1097668003550	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1097668003551	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1097668003552	active site
1097668003553	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1097668003554	rRNA interaction site [nucleotide binding]; other site
1097668003555	S8 interaction site; other site
1097668003556	putative laminin-1 binding site; other site
1097668003557	elongation factor Ts; Provisional; Region: tsf; PRK09377
1097668003558	UBA/TS-N domain; Region: UBA; pfam00627
1097668003559	Elongation factor TS; Region: EF_TS; pfam00889
1097668003560	Elongation factor TS; Region: EF_TS; pfam00889
1097668003561	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1097668003562	putative nucleotide binding site [chemical binding]; other site
1097668003563	uridine monophosphate binding site [chemical binding]; other site
1097668003564	homohexameric interface [polypeptide binding]; other site
1097668003565	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1097668003566	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1097668003567	hinge region; other site
1097668003568	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836
1097668003569	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1097668003570	catalytic residue [active]
1097668003571	putative FPP diphosphate  binding site; other site
1097668003572	putative FPP binding hydrophobic cleft; other site
1097668003573	dimer interface [polypeptide binding]; other site
1097668003574	putative IPP diphosphate binding site; other site
1097668003575	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1097668003576	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1097668003577	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1097668003578	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1097668003579	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1097668003580	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1097668003581	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1097668003582	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1097668003583	active site
1097668003584	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1097668003585	protein binding site [polypeptide binding]; other site
1097668003586	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1097668003587	putative substrate binding region [chemical binding]; other site
1097668003588	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1097668003589	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1097668003590	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1097668003591	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1097668003592	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1097668003593	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1097668003594	Surface antigen; Region: Bac_surface_Ag; pfam01103
1097668003595	periplasmic chaperone; Provisional; Region: PRK10780
1097668003596	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1097668003597	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1097668003598	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1097668003599	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1097668003600	trimer interface [polypeptide binding]; other site
1097668003601	active site
1097668003602	UDP-GlcNAc binding site [chemical binding]; other site
1097668003603	lipid binding site [chemical binding]; lipid-binding site
1097668003604	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1097668003605	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1097668003606	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1097668003607	active site
1097668003608	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1097668003609	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1097668003610	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1097668003611	RNA/DNA hybrid binding site [nucleotide binding]; other site
1097668003612	active site
1097668003613	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1097668003614	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1097668003615	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1097668003616	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1097668003617	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1097668003618	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1097668003619	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1097668003620	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1097668003621	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1097668003622	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1097668003623	SmpB-tmRNA interface; other site
1097668003624	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1097668003625	putative coenzyme Q binding site [chemical binding]; other site
1097668003626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
1097668003627	EamA-like transporter family; Region: EamA; pfam00892
1097668003628	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1097668003629	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1097668003630	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1097668003631	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1097668003632	active site
1097668003633	GMP synthase; Reviewed; Region: guaA; PRK00074
1097668003634	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1097668003635	AMP/PPi binding site [chemical binding]; other site
1097668003636	candidate oxyanion hole; other site
1097668003637	catalytic triad [active]
1097668003638	potential glutamine specificity residues [chemical binding]; other site
1097668003639	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1097668003640	ATP Binding subdomain [chemical binding]; other site
1097668003641	Ligand Binding sites [chemical binding]; other site
1097668003642	Dimerization subdomain; other site
1097668003643	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668003644	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
1097668003645	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1097668003646	D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178
1097668003647	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668003648	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1097668003649	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097668003650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003651	dimer interface [polypeptide binding]; other site
1097668003652	conserved gate region; other site
1097668003653	putative PBP binding loops; other site
1097668003654	ABC-ATPase subunit interface; other site
1097668003655	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097668003656	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003657	dimer interface [polypeptide binding]; other site
1097668003658	conserved gate region; other site
1097668003659	ABC-ATPase subunit interface; other site
1097668003660	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097668003661	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668003662	Walker A/P-loop; other site
1097668003663	ATP binding site [chemical binding]; other site
1097668003664	Q-loop/lid; other site
1097668003665	ABC transporter signature motif; other site
1097668003666	Walker B; other site
1097668003667	D-loop; other site
1097668003668	H-loop/switch region; other site
1097668003669	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097668003670	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668003671	Walker A/P-loop; other site
1097668003672	ATP binding site [chemical binding]; other site
1097668003673	Q-loop/lid; other site
1097668003674	ABC transporter signature motif; other site
1097668003675	Walker B; other site
1097668003676	D-loop; other site
1097668003677	H-loop/switch region; other site
1097668003678	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1097668003679	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1097668003680	nucleoside/Zn binding site; other site
1097668003681	dimer interface [polypeptide binding]; other site
1097668003682	catalytic motif [active]
1097668003683	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1097668003684	dimer interface [polypeptide binding]; other site
1097668003685	catalytic triad [active]
1097668003686	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668003687	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668003688	DNA-binding site [nucleotide binding]; DNA binding site
1097668003689	FCD domain; Region: FCD; pfam07729
1097668003690	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1097668003691	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1097668003692	Na binding site [ion binding]; other site
1097668003693	putative substrate binding site [chemical binding]; other site
1097668003694	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
1097668003695	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1097668003696	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1097668003697	active site
1097668003698	catalytic site [active]
1097668003699	tetramer interface [polypeptide binding]; other site
1097668003700	OHCU decarboxylase; Region: UHCUDC; TIGR03164
1097668003701	allantoicase; Provisional; Region: PRK13257
1097668003702	Allantoicase repeat; Region: Allantoicase; pfam03561
1097668003703	Allantoicase repeat; Region: Allantoicase; pfam03561
1097668003704	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1097668003705	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1097668003706	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1097668003707	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1097668003708	tetramer interface [polypeptide binding]; other site
1097668003709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003710	catalytic residue [active]
1097668003711	Predicted membrane protein [Function unknown]; Region: COG3748
1097668003712	Protein of unknown function (DUF989); Region: DUF989; pfam06181
1097668003713	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668003714	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1097668003715	active site
1097668003716	homotetramer interface [polypeptide binding]; other site
1097668003717	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
1097668003718	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1097668003719	active site
1097668003720	putative substrate binding pocket [chemical binding]; other site
1097668003721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668003722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003723	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463
1097668003724	putative substrate binding pocket [chemical binding]; other site
1097668003725	putative dimerization interface [polypeptide binding]; other site
1097668003726	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1097668003727	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668003728	Walker A/P-loop; other site
1097668003729	ATP binding site [chemical binding]; other site
1097668003730	Q-loop/lid; other site
1097668003731	ABC transporter signature motif; other site
1097668003732	Walker B; other site
1097668003733	D-loop; other site
1097668003734	H-loop/switch region; other site
1097668003735	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668003736	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668003737	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1097668003738	TM-ABC transporter signature motif; other site
1097668003739	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1097668003740	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668003741	TM-ABC transporter signature motif; other site
1097668003742	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1097668003743	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1097668003744	putative ligand binding site [chemical binding]; other site
1097668003745	Dodecin; Region: Dodecin; pfam07311
1097668003746	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1097668003747	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1097668003748	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1097668003749	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1097668003750	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1097668003751	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1097668003752	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1097668003753	active site
1097668003754	catalytic site [active]
1097668003755	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668003756	TPR repeat; Region: TPR_11; pfam13414
1097668003757	TPR motif; other site
1097668003758	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1097668003759	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
1097668003760	Transglycosylase; Region: Transgly; pfam00912
1097668003761	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1097668003762	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1097668003763	CopC domain; Region: CopC; pfam04234
1097668003764	hypothetical protein; Provisional; Region: PRK02487
1097668003765	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1097668003766	Protein of unknown function (DUF3022); Region: DUF3022; pfam11226
1097668003767	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1097668003768	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668003769	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668003770	WHG domain; Region: WHG; pfam13305
1097668003771	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1097668003772	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668003773	substrate binding site [chemical binding]; other site
1097668003774	oxyanion hole (OAH) forming residues; other site
1097668003775	trimer interface [polypeptide binding]; other site
1097668003776	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1097668003777	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1097668003778	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1097668003779	FMN binding site [chemical binding]; other site
1097668003780	active site
1097668003781	catalytic residues [active]
1097668003782	substrate binding site [chemical binding]; other site
1097668003783	O-methyltransferase; Region: Methyltransf_2; pfam00891
1097668003784	short chain dehydrogenase; Provisional; Region: PRK06500
1097668003785	classical (c) SDRs; Region: SDR_c; cd05233
1097668003786	NAD(P) binding site [chemical binding]; other site
1097668003787	active site
1097668003788	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1097668003789	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668003790	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668003791	catalytic residue [active]
1097668003792	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668003793	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668003794	putative substrate translocation pore; other site
1097668003795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668003796	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668003797	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668003798	active site
1097668003799	catalytic tetrad [active]
1097668003800	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1097668003801	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1097668003802	TPP-binding site [chemical binding]; other site
1097668003803	dimer interface [polypeptide binding]; other site
1097668003804	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097668003805	PYR/PP interface [polypeptide binding]; other site
1097668003806	dimer interface [polypeptide binding]; other site
1097668003807	TPP binding site [chemical binding]; other site
1097668003808	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668003809	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668003810	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1097668003811	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1097668003812	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1097668003813	nodulation ABC transporter NodI; Provisional; Region: PRK13537
1097668003814	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1097668003815	Walker A/P-loop; other site
1097668003816	ATP binding site [chemical binding]; other site
1097668003817	Q-loop/lid; other site
1097668003818	ABC transporter signature motif; other site
1097668003819	Walker B; other site
1097668003820	D-loop; other site
1097668003821	H-loop/switch region; other site
1097668003822	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668003823	Ligand Binding Site [chemical binding]; other site
1097668003824	Protein of unknown function (DUF2939); Region: DUF2939; pfam11159
1097668003825	LexA repressor; Validated; Region: PRK00215
1097668003826	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1097668003827	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1097668003828	Catalytic site [active]
1097668003829	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668003830	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1097668003831	substrate binding pocket [chemical binding]; other site
1097668003832	membrane-bound complex binding site; other site
1097668003833	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1097668003834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003835	dimer interface [polypeptide binding]; other site
1097668003836	conserved gate region; other site
1097668003837	putative PBP binding loops; other site
1097668003838	ABC-ATPase subunit interface; other site
1097668003839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003840	dimer interface [polypeptide binding]; other site
1097668003841	conserved gate region; other site
1097668003842	putative PBP binding loops; other site
1097668003843	ABC-ATPase subunit interface; other site
1097668003844	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1097668003845	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1097668003846	Walker A/P-loop; other site
1097668003847	ATP binding site [chemical binding]; other site
1097668003848	Q-loop/lid; other site
1097668003849	ABC transporter signature motif; other site
1097668003850	Walker B; other site
1097668003851	D-loop; other site
1097668003852	H-loop/switch region; other site
1097668003853	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
1097668003854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003855	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1097668003856	substrate binding site [chemical binding]; other site
1097668003857	dimerization interface [polypeptide binding]; other site
1097668003858	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1097668003859	active site
1097668003860	homotetramer interface [polypeptide binding]; other site
1097668003861	homodimer interface [polypeptide binding]; other site
1097668003862	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
1097668003863	BON domain; Region: BON; pfam04972
1097668003864	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097668003865	tartronate semialdehyde reductase; Provisional; Region: PRK15059
1097668003866	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668003867	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
1097668003868	glyoxylate carboligase; Provisional; Region: PRK11269
1097668003869	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668003870	PYR/PP interface [polypeptide binding]; other site
1097668003871	dimer interface [polypeptide binding]; other site
1097668003872	TPP binding site [chemical binding]; other site
1097668003873	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668003874	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1097668003875	TPP-binding site [chemical binding]; other site
1097668003876	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668003877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668003878	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668003879	putative effector binding pocket; other site
1097668003880	dimerization interface [polypeptide binding]; other site
1097668003881	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1097668003882	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1097668003883	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1097668003884	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1097668003885	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1097668003886	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1097668003887	replicative DNA helicase; Provisional; Region: PRK07004
1097668003888	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1097668003889	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1097668003890	Walker A motif; other site
1097668003891	ATP binding site [chemical binding]; other site
1097668003892	Walker B motif; other site
1097668003893	DNA binding loops [nucleotide binding]
1097668003894	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1097668003895	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1097668003896	short chain dehydrogenase; Provisional; Region: PRK06125
1097668003897	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668003898	NAD(P) binding site [chemical binding]; other site
1097668003899	active site
1097668003900	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1097668003901	NlpC/P60 family; Region: NLPC_P60; pfam00877
1097668003902	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1097668003903	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1097668003904	putative active site [active]
1097668003905	PhoH-like protein; Region: PhoH; pfam02562
1097668003906	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1097668003907	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1097668003908	catalytic triad [active]
1097668003909	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1097668003910	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
1097668003911	putative active site [active]
1097668003912	putative catalytic site [active]
1097668003913	putative Zn binding site [ion binding]; other site
1097668003914	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
1097668003915	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1097668003916	NAD binding site [chemical binding]; other site
1097668003917	substrate binding site [chemical binding]; other site
1097668003918	active site
1097668003919	putative formyltransferase; Provisional; Region: PRK06988
1097668003920	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1097668003921	active site
1097668003922	substrate binding site [chemical binding]; other site
1097668003923	cosubstrate binding site; other site
1097668003924	catalytic site [active]
1097668003925	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1097668003926	active site
1097668003927	hexamer interface [polypeptide binding]; other site
1097668003928	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1097668003929	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1097668003930	Ligand binding site; other site
1097668003931	Putative Catalytic site; other site
1097668003932	DXD motif; other site
1097668003933	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1097668003934	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1097668003935	inhibitor-cofactor binding pocket; inhibition site
1097668003936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003937	catalytic residue [active]
1097668003938	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1097668003939	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1097668003940	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1097668003941	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
1097668003942	aminotransferase AlaT; Validated; Region: PRK09265
1097668003943	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668003944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003945	homodimer interface [polypeptide binding]; other site
1097668003946	catalytic residue [active]
1097668003947	homoserine dehydrogenase; Provisional; Region: PRK06349
1097668003948	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1097668003949	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1097668003950	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1097668003951	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1097668003952	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1097668003953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003954	catalytic residue [active]
1097668003955	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1097668003956	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668003957	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668003958	ABC transporter; Region: ABC_tran_2; pfam12848
1097668003959	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668003960	Predicted Fe-S protein [General function prediction only]; Region: COG3313
1097668003961	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
1097668003962	substrate binding site [chemical binding]; other site
1097668003963	dimerization interface [polypeptide binding]; other site
1097668003964	active site
1097668003965	calcium binding site [ion binding]; other site
1097668003966	manganese transport protein MntH; Reviewed; Region: PRK00701
1097668003967	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1097668003968	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1097668003969	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668003970	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1097668003971	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668003972	Walker A/P-loop; other site
1097668003973	ATP binding site [chemical binding]; other site
1097668003974	Q-loop/lid; other site
1097668003975	ABC transporter signature motif; other site
1097668003976	Walker B; other site
1097668003977	D-loop; other site
1097668003978	H-loop/switch region; other site
1097668003979	TOBE domain; Region: TOBE_2; pfam08402
1097668003980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003981	dimer interface [polypeptide binding]; other site
1097668003982	conserved gate region; other site
1097668003983	putative PBP binding loops; other site
1097668003984	ABC-ATPase subunit interface; other site
1097668003985	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668003986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668003987	dimer interface [polypeptide binding]; other site
1097668003988	conserved gate region; other site
1097668003989	putative PBP binding loops; other site
1097668003990	ABC-ATPase subunit interface; other site
1097668003991	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1097668003992	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1097668003993	tetramer interface [polypeptide binding]; other site
1097668003994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668003995	catalytic residue [active]
1097668003996	acetylornithine deacetylase; Provisional; Region: PRK07522
1097668003997	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1097668003998	metal binding site [ion binding]; metal-binding site
1097668003999	putative dimer interface [polypeptide binding]; other site
1097668004000	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1097668004001	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1097668004002	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668004003	ATP binding site [chemical binding]; other site
1097668004004	putative Mg++ binding site [ion binding]; other site
1097668004005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668004006	nucleotide binding region [chemical binding]; other site
1097668004007	ATP-binding site [chemical binding]; other site
1097668004008	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1097668004009	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1097668004010	substrate binding site; other site
1097668004011	dimer interface; other site
1097668004012	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1097668004013	homotrimer interaction site [polypeptide binding]; other site
1097668004014	zinc binding site [ion binding]; other site
1097668004015	CDP-binding sites; other site
1097668004016	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1097668004017	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668004018	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1097668004019	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1097668004020	dimer interface [polypeptide binding]; other site
1097668004021	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1097668004022	catalytic triad [active]
1097668004023	peroxidatic and resolving cysteines [active]
1097668004024	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1097668004025	dimerization interface [polypeptide binding]; other site
1097668004026	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1097668004027	dimer interface [polypeptide binding]; other site
1097668004028	phosphorylation site [posttranslational modification]
1097668004029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668004030	ATP binding site [chemical binding]; other site
1097668004031	Mg2+ binding site [ion binding]; other site
1097668004032	G-X-G motif; other site
1097668004033	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1097668004034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668004035	active site
1097668004036	phosphorylation site [posttranslational modification]
1097668004037	intermolecular recognition site; other site
1097668004038	dimerization interface [polypeptide binding]; other site
1097668004039	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668004040	DNA binding site [nucleotide binding]
1097668004041	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
1097668004042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
1097668004043	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1097668004044	substrate binding pocket [chemical binding]; other site
1097668004045	substrate-Mg2+ binding site; other site
1097668004046	aspartate-rich region 1; other site
1097668004047	aspartate-rich region 2; other site
1097668004048	Protein of unknown function (DUF2946); Region: DUF2946; pfam11162
1097668004049	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1097668004050	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668004051	N-terminal plug; other site
1097668004052	ligand-binding site [chemical binding]; other site
1097668004053	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1097668004054	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1097668004055	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1097668004056	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1097668004057	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1097668004058	trigger factor; Provisional; Region: tig; PRK01490
1097668004059	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1097668004060	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1097668004061	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1097668004062	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1097668004063	oligomer interface [polypeptide binding]; other site
1097668004064	active site residues [active]
1097668004065	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1097668004066	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1097668004067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668004068	Walker A motif; other site
1097668004069	ATP binding site [chemical binding]; other site
1097668004070	Walker B motif; other site
1097668004071	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1097668004072	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1097668004073	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1097668004074	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668004075	Walker A motif; other site
1097668004076	ATP binding site [chemical binding]; other site
1097668004077	Walker B motif; other site
1097668004078	arginine finger; other site
1097668004079	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1097668004080	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097668004081	IHF dimer interface [polypeptide binding]; other site
1097668004082	IHF - DNA interface [nucleotide binding]; other site
1097668004083	SurA N-terminal domain; Region: SurA_N_3; cl07813
1097668004084	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1097668004085	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1097668004086	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1097668004087	active site
1097668004088	catalytic triad [active]
1097668004089	oxyanion hole [active]
1097668004090	switch loop; other site
1097668004091	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1097668004092	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1097668004093	Walker A/P-loop; other site
1097668004094	ATP binding site [chemical binding]; other site
1097668004095	Q-loop/lid; other site
1097668004096	ABC transporter signature motif; other site
1097668004097	Walker B; other site
1097668004098	D-loop; other site
1097668004099	H-loop/switch region; other site
1097668004100	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1097668004101	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1097668004102	active site
1097668004103	dimer interface [polypeptide binding]; other site
1097668004104	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1097668004105	dimer interface [polypeptide binding]; other site
1097668004106	active site
1097668004107	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1097668004108	putative carbohydrate kinase; Provisional; Region: PRK10565
1097668004109	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1097668004110	putative substrate binding site [chemical binding]; other site
1097668004111	putative ATP binding site [chemical binding]; other site
1097668004112	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1097668004113	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1097668004114	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1097668004115	dimerization interface [polypeptide binding]; other site
1097668004116	ATP binding site [chemical binding]; other site
1097668004117	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1097668004118	dimerization interface [polypeptide binding]; other site
1097668004119	ATP binding site [chemical binding]; other site
1097668004120	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1097668004121	putative active site [active]
1097668004122	catalytic triad [active]
1097668004123	putative transposase OrfB; Reviewed; Region: PHA02517
1097668004124	HTH-like domain; Region: HTH_21; pfam13276
1097668004125	Integrase core domain; Region: rve; pfam00665
1097668004126	Integrase core domain; Region: rve_2; pfam13333
1097668004127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668004128	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668004129	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668004130	Putative carbohydrate binding domain; Region: CHB_HEX; cl03918
1097668004131	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
1097668004132	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
1097668004133	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1097668004134	active site
1097668004135	SurA N-terminal domain; Region: SurA_N_3; cl07813
1097668004136	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1097668004137	BolA-like protein; Region: BolA; pfam01722
1097668004138	intracellular septation protein A; Reviewed; Region: PRK00259
1097668004139	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1097668004140	SelR domain; Region: SelR; pfam01641
1097668004141	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1097668004142	hypothetical protein; Validated; Region: PRK00029
1097668004143	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
1097668004144	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1097668004145	dimer interface [polypeptide binding]; other site
1097668004146	acyl-activating enzyme (AAE) consensus motif; other site
1097668004147	putative active site [active]
1097668004148	AMP binding site [chemical binding]; other site
1097668004149	putative CoA binding site [chemical binding]; other site
1097668004150	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1097668004151	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668004152	substrate binding site [chemical binding]; other site
1097668004153	oxyanion hole (OAH) forming residues; other site
1097668004154	trimer interface [polypeptide binding]; other site
1097668004155	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668004156	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668004157	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668004158	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1097668004159	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668004160	catalytic triad [active]
1097668004161	metal binding site [ion binding]; metal-binding site
1097668004162	conserved cis-peptide bond; other site
1097668004163	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
1097668004164	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668004165	dimer interface [polypeptide binding]; other site
1097668004166	active site
1097668004167	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1097668004168	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097668004169	CoenzymeA binding site [chemical binding]; other site
1097668004170	subunit interaction site [polypeptide binding]; other site
1097668004171	PHB binding site; other site
1097668004172	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1097668004173	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1097668004174	NAD(P) binding site [chemical binding]; other site
1097668004175	substrate binding site [chemical binding]; other site
1097668004176	dimer interface [polypeptide binding]; other site
1097668004177	hypothetical protein; Provisional; Region: PRK06194
1097668004178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668004179	NAD(P) binding site [chemical binding]; other site
1097668004180	active site
1097668004181	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668004182	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1097668004183	substrate binding pocket [chemical binding]; other site
1097668004184	NRDE protein; Region: NRDE; cl01315
1097668004185	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1097668004186	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1097668004187	YceG-like family; Region: YceG; pfam02618
1097668004188	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1097668004189	dimerization interface [polypeptide binding]; other site
1097668004190	thymidylate kinase; Validated; Region: tmk; PRK00698
1097668004191	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1097668004192	TMP-binding site; other site
1097668004193	ATP-binding site [chemical binding]; other site
1097668004194	DNA polymerase III subunit delta'; Validated; Region: PRK06964
1097668004195	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1097668004196	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1097668004197	active site
1097668004198	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1097668004199	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1097668004200	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1097668004201	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668004202	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668004203	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1097668004204	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1097668004205	active site
1097668004206	homotetramer interface [polypeptide binding]; other site
1097668004207	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1097668004208	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668004209	putative ADP-binding pocket [chemical binding]; other site
1097668004210	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
1097668004211	hypothetical protein; Provisional; Region: PRK11505
1097668004212	psiF repeat; Region: PsiF_repeat; pfam07769
1097668004213	psiF repeat; Region: PsiF_repeat; pfam07769
1097668004214	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1097668004215	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668004216	ligand binding site [chemical binding]; other site
1097668004217	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668004218	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668004219	Walker A/P-loop; other site
1097668004220	ATP binding site [chemical binding]; other site
1097668004221	Q-loop/lid; other site
1097668004222	ABC transporter signature motif; other site
1097668004223	Walker B; other site
1097668004224	D-loop; other site
1097668004225	H-loop/switch region; other site
1097668004226	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668004227	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668004228	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668004229	TM-ABC transporter signature motif; other site
1097668004230	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668004231	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668004232	DNA binding site [nucleotide binding]
1097668004233	domain linker motif; other site
1097668004234	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668004235	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097668004236	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1097668004237	substrate binding site [chemical binding]; other site
1097668004238	dimer interface [polypeptide binding]; other site
1097668004239	ATP binding site [chemical binding]; other site
1097668004240	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1097668004241	Tar ligand binding domain homologue; Region: TarH; pfam02203
1097668004242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668004243	dimerization interface [polypeptide binding]; other site
1097668004244	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1097668004245	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668004246	dimer interface [polypeptide binding]; other site
1097668004247	putative CheW interface [polypeptide binding]; other site
1097668004248	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1097668004249	PrkA family serine protein kinase; Provisional; Region: PRK15455
1097668004250	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1097668004251	hypothetical protein; Provisional; Region: PRK05325
1097668004252	SpoVR family protein; Provisional; Region: PRK11767
1097668004253	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1097668004254	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097668004255	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1097668004256	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1097668004257	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668004258	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668004259	active site
1097668004260	catalytic tetrad [active]
1097668004261	putative transporter; Provisional; Region: PRK10504
1097668004262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004263	putative substrate translocation pore; other site
1097668004264	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004265	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668004266	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668004267	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668004268	dimerization interface [polypeptide binding]; other site
1097668004269	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1097668004270	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
1097668004271	YCII-related domain; Region: YCII; cl00999
1097668004272	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1097668004273	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668004274	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1097668004275	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668004276	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1097668004277	DNA binding residues [nucleotide binding]
1097668004278	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668004279	Winged helix-turn helix; Region: HTH_29; pfam13551
1097668004280	Homeodomain-like domain; Region: HTH_32; pfam13565
1097668004281	Integrase core domain; Region: rve; pfam00665
1097668004282	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1097668004283	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1097668004284	homodimer interface [polypeptide binding]; other site
1097668004285	substrate-cofactor binding pocket; other site
1097668004286	catalytic residue [active]
1097668004287	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1097668004288	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1097668004289	active site
1097668004290	catalytic residues [active]
1097668004291	metal binding site [ion binding]; metal-binding site
1097668004292	alanine racemase; Region: alr; TIGR00492
1097668004293	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1097668004294	active site
1097668004295	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668004296	dimer interface [polypeptide binding]; other site
1097668004297	substrate binding site [chemical binding]; other site
1097668004298	catalytic residues [active]
1097668004299	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1097668004300	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1097668004301	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1097668004302	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097668004303	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097668004304	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668004305	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668004306	trimer interface [polypeptide binding]; other site
1097668004307	eyelet of channel; other site
1097668004308	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097668004309	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668004310	Walker A/P-loop; other site
1097668004311	ATP binding site [chemical binding]; other site
1097668004312	Q-loop/lid; other site
1097668004313	ABC transporter signature motif; other site
1097668004314	Walker B; other site
1097668004315	D-loop; other site
1097668004316	H-loop/switch region; other site
1097668004317	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668004318	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1097668004319	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668004320	Walker A/P-loop; other site
1097668004321	ATP binding site [chemical binding]; other site
1097668004322	Q-loop/lid; other site
1097668004323	ABC transporter signature motif; other site
1097668004324	Walker B; other site
1097668004325	D-loop; other site
1097668004326	H-loop/switch region; other site
1097668004327	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668004328	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097668004329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668004330	dimer interface [polypeptide binding]; other site
1097668004331	conserved gate region; other site
1097668004332	putative PBP binding loops; other site
1097668004333	ABC-ATPase subunit interface; other site
1097668004334	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097668004335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668004336	dimer interface [polypeptide binding]; other site
1097668004337	conserved gate region; other site
1097668004338	putative PBP binding loops; other site
1097668004339	ABC-ATPase subunit interface; other site
1097668004340	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668004341	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1097668004342	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668004343	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668004344	DNA binding site [nucleotide binding]
1097668004345	domain linker motif; other site
1097668004346	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_5; cd06281
1097668004347	putative dimerization interface [polypeptide binding]; other site
1097668004348	putative ligand binding site [chemical binding]; other site
1097668004349	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1097668004350	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1097668004351	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668004352	The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450
1097668004353	putative dimerization interface [polypeptide binding]; other site
1097668004354	putative substrate binding pocket [chemical binding]; other site
1097668004355	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668004356	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668004357	NAD(P) binding site [chemical binding]; other site
1097668004358	active site
1097668004359	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097668004360	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1097668004361	FMN binding site [chemical binding]; other site
1097668004362	active site
1097668004363	substrate binding site [chemical binding]; other site
1097668004364	catalytic residue [active]
1097668004365	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668004366	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1097668004367	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668004368	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668004369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668004370	NAD(P) binding site [chemical binding]; other site
1097668004371	active site
1097668004372	short chain dehydrogenase; Provisional; Region: PRK06172
1097668004373	classical (c) SDRs; Region: SDR_c; cd05233
1097668004374	NAD(P) binding site [chemical binding]; other site
1097668004375	active site
1097668004376	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668004377	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
1097668004378	putative C-terminal domain interface [polypeptide binding]; other site
1097668004379	putative GSH binding site (G-site) [chemical binding]; other site
1097668004380	putative dimer interface [polypeptide binding]; other site
1097668004381	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668004382	N-terminal domain interface [polypeptide binding]; other site
1097668004383	dimer interface [polypeptide binding]; other site
1097668004384	substrate binding pocket (H-site) [chemical binding]; other site
1097668004385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004386	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668004387	putative substrate translocation pore; other site
1097668004388	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1097668004389	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668004390	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668004391	acyl-activating enzyme (AAE) consensus motif; other site
1097668004392	acyl-activating enzyme (AAE) consensus motif; other site
1097668004393	AMP binding site [chemical binding]; other site
1097668004394	active site
1097668004395	CoA binding site [chemical binding]; other site
1097668004396	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668004397	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668004398	catalytic loop [active]
1097668004399	iron binding site [ion binding]; other site
1097668004400	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668004401	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1097668004402	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1097668004403	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668004404	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668004405	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668004406	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1097668004407	putative hydrophobic ligand binding site [chemical binding]; other site
1097668004408	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1097668004409	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668004410	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668004411	enoyl-CoA hydratase; Provisional; Region: PRK06688
1097668004412	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668004413	substrate binding site [chemical binding]; other site
1097668004414	oxyanion hole (OAH) forming residues; other site
1097668004415	trimer interface [polypeptide binding]; other site
1097668004416	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
1097668004417	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1097668004418	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1097668004419	active site
1097668004420	catalytic residues [active]
1097668004421	metal binding site [ion binding]; metal-binding site
1097668004422	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1097668004423	homodimer interface [polypeptide binding]; other site
1097668004424	catalytic residues [active]
1097668004425	NAD binding site [chemical binding]; other site
1097668004426	substrate binding pocket [chemical binding]; other site
1097668004427	flexible flap; other site
1097668004428	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668004429	DNA-binding site [nucleotide binding]; DNA binding site
1097668004430	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668004431	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668004432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668004433	homodimer interface [polypeptide binding]; other site
1097668004434	catalytic residue [active]
1097668004435	MAPEG family; Region: MAPEG; cl09190
1097668004436	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1097668004437	BON domain; Region: BON; pfam04972
1097668004438	BON domain; Region: BON; pfam04972
1097668004439	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097668004440	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
1097668004441	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097668004442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668004443	active site
1097668004444	motif I; other site
1097668004445	motif II; other site
1097668004446	Hemerythrin-like domain; Region: Hr-like; cd12108
1097668004447	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668004448	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1097668004449	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668004450	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1097668004451	BON domain; Region: BON; pfam04972
1097668004452	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1097668004453	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1097668004454	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1097668004455	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1097668004456	putative FMN binding site [chemical binding]; other site
1097668004457	NADPH bind site [chemical binding]; other site
1097668004458	Hemerythrin-like domain; Region: Hr-like; cd12108
1097668004459	Fe binding site [ion binding]; other site
1097668004460	Cytochrome c; Region: Cytochrom_C; cl11414
1097668004461	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668004462	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668004463	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1097668004464	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668004465	BON domain; Region: BON; pfam04972
1097668004466	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1097668004467	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004468	Ligand Binding Site [chemical binding]; other site
1097668004469	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004470	Ligand Binding Site [chemical binding]; other site
1097668004471	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1097668004472	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668004473	Beta-Casp domain; Region: Beta-Casp; smart01027
1097668004474	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1097668004475	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1097668004476	BON domain; Region: BON; pfam04972
1097668004477	BON domain; Region: BON; pfam04972
1097668004478	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1097668004479	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
1097668004480	putative dimer interface [polypeptide binding]; other site
1097668004481	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668004482	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004483	Ligand Binding Site [chemical binding]; other site
1097668004484	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1097668004485	FMN binding site [chemical binding]; other site
1097668004486	dimer interface [polypeptide binding]; other site
1097668004487	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1097668004488	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
1097668004489	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1097668004490	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004491	Ligand Binding Site [chemical binding]; other site
1097668004492	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004493	Ligand Binding Site [chemical binding]; other site
1097668004494	PAS domain S-box; Region: sensory_box; TIGR00229
1097668004495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668004496	putative active site [active]
1097668004497	heme pocket [chemical binding]; other site
1097668004498	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097668004499	Histidine kinase; Region: HisKA_3; pfam07730
1097668004500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668004501	ATP binding site [chemical binding]; other site
1097668004502	Mg2+ binding site [ion binding]; other site
1097668004503	G-X-G motif; other site
1097668004504	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668004505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668004506	active site
1097668004507	phosphorylation site [posttranslational modification]
1097668004508	intermolecular recognition site; other site
1097668004509	dimerization interface [polypeptide binding]; other site
1097668004510	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668004511	DNA binding residues [nucleotide binding]
1097668004512	dimerization interface [polypeptide binding]; other site
1097668004513	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1097668004514	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668004515	ligand binding site [chemical binding]; other site
1097668004516	flexible hinge region; other site
1097668004517	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097668004518	putative switch regulator; other site
1097668004519	non-specific DNA interactions [nucleotide binding]; other site
1097668004520	DNA binding site [nucleotide binding]
1097668004521	sequence specific DNA binding site [nucleotide binding]; other site
1097668004522	putative cAMP binding site [chemical binding]; other site
1097668004523	Cytochrome c; Region: Cytochrom_C; cl11414
1097668004524	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
1097668004525	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004526	Ligand Binding Site [chemical binding]; other site
1097668004527	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004528	Ligand Binding Site [chemical binding]; other site
1097668004529	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004530	Ligand Binding Site [chemical binding]; other site
1097668004531	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668004532	Ligand Binding Site [chemical binding]; other site
1097668004533	Predicted transporter component [General function prediction only]; Region: COG2391
1097668004534	Sulphur transport; Region: Sulf_transp; pfam04143
1097668004535	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1097668004536	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1097668004537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668004538	active site
1097668004539	phosphorylation site [posttranslational modification]
1097668004540	intermolecular recognition site; other site
1097668004541	dimerization interface [polypeptide binding]; other site
1097668004542	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668004543	DNA binding site [nucleotide binding]
1097668004544	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668004545	HAMP domain; Region: HAMP; pfam00672
1097668004546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668004547	dimer interface [polypeptide binding]; other site
1097668004548	phosphorylation site [posttranslational modification]
1097668004549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668004550	ATP binding site [chemical binding]; other site
1097668004551	G-X-G motif; other site
1097668004552	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668004553	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668004554	DNA-binding site [nucleotide binding]; DNA binding site
1097668004555	FCD domain; Region: FCD; pfam07729
1097668004556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004557	putative substrate translocation pore; other site
1097668004558	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1097668004559	dihydropyrimidinase; Provisional; Region: PRK13404
1097668004560	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1097668004561	tetramer interface [polypeptide binding]; other site
1097668004562	active site
1097668004563	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097668004564	Beta-lactamase; Region: Beta-lactamase; pfam00144
1097668004565	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097668004566	Beta-lactamase; Region: Beta-lactamase; pfam00144
1097668004567	benzoate transport; Region: 2A0115; TIGR00895
1097668004568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004569	putative substrate translocation pore; other site
1097668004570	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1097668004571	hypothetical protein; Provisional; Region: PRK07236
1097668004572	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1097668004573	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097668004574	active site
1097668004575	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1097668004576	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668004577	acyl-activating enzyme (AAE) consensus motif; other site
1097668004578	AMP binding site [chemical binding]; other site
1097668004579	active site
1097668004580	CoA binding site [chemical binding]; other site
1097668004581	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1097668004582	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668004583	Zn binding site [ion binding]; other site
1097668004584	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668004585	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668004586	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1097668004587	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668004588	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668004589	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668004590	dimerization interface [polypeptide binding]; other site
1097668004591	hypothetical protein; Provisional; Region: PRK05463
1097668004592	benzoate transport; Region: 2A0115; TIGR00895
1097668004593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004594	putative substrate translocation pore; other site
1097668004595	5-oxoprolinase; Region: PLN02666
1097668004596	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097668004597	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097668004598	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1097668004599	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1097668004600	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1097668004601	dimer interface [polypeptide binding]; other site
1097668004602	active site
1097668004603	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
1097668004604	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
1097668004605	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1097668004606	octamer interface [polypeptide binding]; other site
1097668004607	active site
1097668004608	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668004609	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668004610	trimer interface [polypeptide binding]; other site
1097668004611	eyelet of channel; other site
1097668004612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004613	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668004614	putative substrate translocation pore; other site
1097668004615	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668004616	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668004617	active site
1097668004618	Flavin Reductases; Region: FlaRed; cl00801
1097668004619	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668004620	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668004621	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668004622	substrate binding pocket [chemical binding]; other site
1097668004623	dimerization interface [polypeptide binding]; other site
1097668004624	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668004625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004626	putative substrate translocation pore; other site
1097668004627	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1097668004628	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668004629	[2Fe-2S] cluster binding site [ion binding]; other site
1097668004630	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1097668004631	putative alpha subunit interface [polypeptide binding]; other site
1097668004632	putative active site [active]
1097668004633	putative substrate binding site [chemical binding]; other site
1097668004634	Fe binding site [ion binding]; other site
1097668004635	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097668004636	Tautomerase enzyme; Region: Tautomerase; pfam01361
1097668004637	active site 1 [active]
1097668004638	dimer interface [polypeptide binding]; other site
1097668004639	hexamer interface [polypeptide binding]; other site
1097668004640	active site 2 [active]
1097668004641	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668004642	hexamer interface [polypeptide binding]; other site
1097668004643	active site 2 [active]
1097668004644	SnoaL-like domain; Region: SnoaL_4; pfam13577
1097668004645	Amidase; Region: Amidase; cl11426
1097668004646	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1097668004647	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1097668004648	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668004649	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668004650	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
1097668004651	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1097668004652	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1097668004653	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1097668004654	ligand binding site [chemical binding]; other site
1097668004655	homodimer interface [polypeptide binding]; other site
1097668004656	NAD(P) binding site [chemical binding]; other site
1097668004657	trimer interface B [polypeptide binding]; other site
1097668004658	trimer interface A [polypeptide binding]; other site
1097668004659	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1097668004660	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1097668004661	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
1097668004662	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668004663	PAS fold; Region: PAS; pfam00989
1097668004664	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668004665	putative active site [active]
1097668004666	heme pocket [chemical binding]; other site
1097668004667	formyl-coenzyme A transferase; Provisional; Region: PRK05398
1097668004668	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668004669	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
1097668004670	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668004671	PYR/PP interface [polypeptide binding]; other site
1097668004672	dimer interface [polypeptide binding]; other site
1097668004673	TPP binding site [chemical binding]; other site
1097668004674	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668004675	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
1097668004676	TPP-binding site; other site
1097668004677	dimer interface [polypeptide binding]; other site
1097668004678	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668004679	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668004680	DNA-binding site [nucleotide binding]; DNA binding site
1097668004681	FCD domain; Region: FCD; pfam07729
1097668004682	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1097668004683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004684	putative substrate translocation pore; other site
1097668004685	Fic family protein [Function unknown]; Region: COG3177
1097668004686	Fic/DOC family; Region: Fic; pfam02661
1097668004687	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
1097668004688	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
1097668004689	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
1097668004690	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1097668004691	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1097668004692	C-terminal domain interface [polypeptide binding]; other site
1097668004693	GSH binding site (G-site) [chemical binding]; other site
1097668004694	dimer interface [polypeptide binding]; other site
1097668004695	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668004696	N-terminal domain interface [polypeptide binding]; other site
1097668004697	dimer interface [polypeptide binding]; other site
1097668004698	substrate binding pocket (H-site) [chemical binding]; other site
1097668004699	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1097668004700	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1097668004701	Walker A/P-loop; other site
1097668004702	ATP binding site [chemical binding]; other site
1097668004703	Q-loop/lid; other site
1097668004704	ABC transporter signature motif; other site
1097668004705	Walker B; other site
1097668004706	D-loop; other site
1097668004707	H-loop/switch region; other site
1097668004708	TOBE domain; Region: TOBE_2; pfam08402
1097668004709	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1097668004710	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1097668004711	Walker A/P-loop; other site
1097668004712	ATP binding site [chemical binding]; other site
1097668004713	Q-loop/lid; other site
1097668004714	ABC transporter signature motif; other site
1097668004715	Walker B; other site
1097668004716	D-loop; other site
1097668004717	H-loop/switch region; other site
1097668004718	TOBE domain; Region: TOBE_2; pfam08402
1097668004719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668004720	dimer interface [polypeptide binding]; other site
1097668004721	conserved gate region; other site
1097668004722	putative PBP binding loops; other site
1097668004723	ABC-ATPase subunit interface; other site
1097668004724	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097668004725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668004726	dimer interface [polypeptide binding]; other site
1097668004727	conserved gate region; other site
1097668004728	putative PBP binding loops; other site
1097668004729	ABC-ATPase subunit interface; other site
1097668004730	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
1097668004731	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097668004732	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
1097668004733	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668004734	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1097668004735	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668004736	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
1097668004737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668004738	TPR motif; other site
1097668004739	binding surface
1097668004740	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668004741	binding surface
1097668004742	TPR motif; other site
1097668004743	TPR repeat; Region: TPR_11; pfam13414
1097668004744	TPR repeat; Region: TPR_11; pfam13414
1097668004745	TPR repeat; Region: TPR_11; pfam13414
1097668004746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668004747	binding surface
1097668004748	TPR motif; other site
1097668004749	TPR repeat; Region: TPR_11; pfam13414
1097668004750	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1097668004751	active site clefts [active]
1097668004752	zinc binding site [ion binding]; other site
1097668004753	dimer interface [polypeptide binding]; other site
1097668004754	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1097668004755	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
1097668004756	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1097668004757	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1097668004758	active site
1097668004759	phosphorylation site [posttranslational modification]
1097668004760	intermolecular recognition site; other site
1097668004761	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1097668004762	EamA-like transporter family; Region: EamA; pfam00892
1097668004763	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1097668004764	EamA-like transporter family; Region: EamA; pfam00892
1097668004765	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
1097668004766	transcriptional regulator; Provisional; Region: PRK10632
1097668004767	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668004768	putative effector binding pocket; other site
1097668004769	dimerization interface [polypeptide binding]; other site
1097668004770	haemagglutination activity domain; Region: Haemagg_act; smart00912
1097668004771	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1097668004772	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1097668004773	FecR protein; Region: FecR; pfam04773
1097668004774	CHASE2 domain; Region: CHASE2; pfam05226
1097668004775	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1097668004776	cyclase homology domain; Region: CHD; cd07302
1097668004777	nucleotidyl binding site; other site
1097668004778	metal binding site [ion binding]; metal-binding site
1097668004779	dimer interface [polypeptide binding]; other site
1097668004780	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
1097668004781	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
1097668004782	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1097668004783	gating phenylalanine in ion channel; other site
1097668004784	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1097668004785	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668004786	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1097668004787	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
1097668004788	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1097668004789	Na binding site [ion binding]; other site
1097668004790	putative substrate binding site [chemical binding]; other site
1097668004791	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1097668004792	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1097668004793	EamA-like transporter family; Region: EamA; pfam00892
1097668004794	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668004795	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668004796	metal binding site [ion binding]; metal-binding site
1097668004797	active site
1097668004798	I-site; other site
1097668004799	recombination associated protein; Reviewed; Region: rdgC; PRK00321
1097668004800	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668004801	salt bridge; other site
1097668004802	non-specific DNA binding site [nucleotide binding]; other site
1097668004803	sequence-specific DNA binding site [nucleotide binding]; other site
1097668004804	EamA-like transporter family; Region: EamA; pfam00892
1097668004805	EamA-like transporter family; Region: EamA; pfam00892
1097668004806	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668004807	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1097668004808	dimerization interface [polypeptide binding]; other site
1097668004809	putative DNA binding site [nucleotide binding]; other site
1097668004810	putative Zn2+ binding site [ion binding]; other site
1097668004811	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668004812	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
1097668004813	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668004814	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668004815	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668004816	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097668004817	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
1097668004818	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1097668004819	active site
1097668004820	AMP binding site [chemical binding]; other site
1097668004821	homodimer interface [polypeptide binding]; other site
1097668004822	acyl-activating enzyme (AAE) consensus motif; other site
1097668004823	CoA binding site [chemical binding]; other site
1097668004824	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1097668004825	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668004826	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668004827	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668004828	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1097668004829	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668004830	dimer interface [polypeptide binding]; other site
1097668004831	active site
1097668004832	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1097668004833	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1097668004834	FAD binding pocket [chemical binding]; other site
1097668004835	FAD binding motif [chemical binding]; other site
1097668004836	phosphate binding motif [ion binding]; other site
1097668004837	beta-alpha-beta structure motif; other site
1097668004838	NAD(p) ribose binding residues [chemical binding]; other site
1097668004839	NAD binding pocket [chemical binding]; other site
1097668004840	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1097668004841	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668004842	catalytic loop [active]
1097668004843	iron binding site [ion binding]; other site
1097668004844	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1097668004845	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1097668004846	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1097668004847	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1097668004848	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1097668004849	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1097668004850	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668004851	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668004852	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
1097668004853	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668004854	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668004855	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668004856	NAD(P) binding site [chemical binding]; other site
1097668004857	active site
1097668004858	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668004859	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668004860	trimer interface [polypeptide binding]; other site
1097668004861	eyelet of channel; other site
1097668004862	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668004863	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668004864	[2Fe-2S] cluster binding site [ion binding]; other site
1097668004865	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668004866	transcriptional regulator; Provisional; Region: PRK10632
1097668004867	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668004868	putative effector binding pocket; other site
1097668004869	dimerization interface [polypeptide binding]; other site
1097668004870	EamA-like transporter family; Region: EamA; pfam00892
1097668004871	Protein of unknown function (DUF938); Region: DUF938; pfam06080
1097668004872	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1097668004873	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1097668004874	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1097668004875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004876	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668004877	putative substrate translocation pore; other site
1097668004878	mercuric reductase; Validated; Region: PRK06370
1097668004879	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668004880	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668004881	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668004882	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1097668004883	AAA domain; Region: AAA_33; pfam13671
1097668004884	AAA domain; Region: AAA_17; pfam13207
1097668004885	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1097668004886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668004887	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668004888	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1097668004889	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668004890	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668004891	LysR family transcriptional regulator; Provisional; Region: PRK14997
1097668004892	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668004893	dimerization interface [polypeptide binding]; other site
1097668004894	LTXXQ motif family protein; Region: LTXXQ; pfam07813
1097668004895	PGDYG protein; Region: PGDYG; pfam14083
1097668004896	Protein of unknown function (DUF3022); Region: DUF3022; pfam11226
1097668004897	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
1097668004898	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668004899	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668004900	DNA binding site [nucleotide binding]
1097668004901	domain linker motif; other site
1097668004902	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
1097668004903	putative dimerization interface [polypeptide binding]; other site
1097668004904	putative ligand binding site [chemical binding]; other site
1097668004905	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1097668004906	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1097668004907	dimerization interface [polypeptide binding]; other site
1097668004908	ligand binding site [chemical binding]; other site
1097668004909	NADP binding site [chemical binding]; other site
1097668004910	catalytic site [active]
1097668004911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668004912	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668004913	putative substrate translocation pore; other site
1097668004914	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097668004915	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1097668004916	substrate binding site [chemical binding]; other site
1097668004917	ATP binding site [chemical binding]; other site
1097668004918	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097668004919	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668004920	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1097668004921	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1097668004922	putative dimerization interface [polypeptide binding]; other site
1097668004923	Predicted membrane protein [Function unknown]; Region: COG2855
1097668004924	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1097668004925	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668004926	molybdopterin cofactor binding site; other site
1097668004927	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668004928	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
1097668004929	putative molybdopterin cofactor binding site; other site
1097668004930	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
1097668004931	4Fe-4S binding domain; Region: Fer4; pfam00037
1097668004932	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
1097668004933	hypothetical protein; Provisional; Region: PRK05939
1097668004934	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097668004935	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668004936	catalytic residue [active]
1097668004937	GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039
1097668004938	glutathione s-transferase; Provisional; Region: PTZ00057
1097668004939	GSH binding site (G-site) [chemical binding]; other site
1097668004940	C-terminal domain interface [polypeptide binding]; other site
1097668004941	dimer interface [polypeptide binding]; other site
1097668004942	C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192
1097668004943	dimer interface [polypeptide binding]; other site
1097668004944	N-terminal domain interface [polypeptide binding]; other site
1097668004945	substrate binding pocket (H-site) [chemical binding]; other site
1097668004946	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668004947	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668004948	active site
1097668004949	catalytic tetrad [active]
1097668004950	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
1097668004951	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1097668004952	Cl- selectivity filter; other site
1097668004953	Cl- binding residues [ion binding]; other site
1097668004954	pore gating glutamate residue; other site
1097668004955	dimer interface [polypeptide binding]; other site
1097668004956	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1097668004957	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
1097668004958	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1097668004959	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1097668004960	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1097668004961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668004962	Walker A/P-loop; other site
1097668004963	ATP binding site [chemical binding]; other site
1097668004964	Q-loop/lid; other site
1097668004965	ABC transporter signature motif; other site
1097668004966	Walker B; other site
1097668004967	D-loop; other site
1097668004968	H-loop/switch region; other site
1097668004969	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1097668004970	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668004971	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1097668004972	dimer interface [polypeptide binding]; other site
1097668004973	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1097668004974	putative dimer interface [polypeptide binding]; other site
1097668004975	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668004976	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668004977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668004978	active site
1097668004979	phosphorylation site [posttranslational modification]
1097668004980	intermolecular recognition site; other site
1097668004981	dimerization interface [polypeptide binding]; other site
1097668004982	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1097668004983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668004984	putative active site [active]
1097668004985	heme pocket [chemical binding]; other site
1097668004986	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668004987	dimer interface [polypeptide binding]; other site
1097668004988	phosphorylation site [posttranslational modification]
1097668004989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668004990	ATP binding site [chemical binding]; other site
1097668004991	Mg2+ binding site [ion binding]; other site
1097668004992	G-X-G motif; other site
1097668004993	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668004994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668004995	active site
1097668004996	phosphorylation site [posttranslational modification]
1097668004997	intermolecular recognition site; other site
1097668004998	dimerization interface [polypeptide binding]; other site
1097668004999	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668005000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668005001	active site
1097668005002	phosphorylation site [posttranslational modification]
1097668005003	intermolecular recognition site; other site
1097668005004	dimerization interface [polypeptide binding]; other site
1097668005005	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1097668005006	GAF domain; Region: GAF; pfam01590
1097668005007	Phytochrome region; Region: PHY; pfam00360
1097668005008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668005009	dimer interface [polypeptide binding]; other site
1097668005010	phosphorylation site [posttranslational modification]
1097668005011	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668005012	ATP binding site [chemical binding]; other site
1097668005013	Mg2+ binding site [ion binding]; other site
1097668005014	G-X-G motif; other site
1097668005015	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
1097668005016	heme binding pocket [chemical binding]; other site
1097668005017	heme ligand [chemical binding]; other site
1097668005018	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
1097668005019	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
1097668005020	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1097668005021	active site
1097668005022	DNA binding site [nucleotide binding]
1097668005023	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1097668005024	DNA binding site [nucleotide binding]
1097668005025	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
1097668005026	nucleotide binding site [chemical binding]; other site
1097668005027	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1097668005028	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1097668005029	putative DNA binding site [nucleotide binding]; other site
1097668005030	putative homodimer interface [polypeptide binding]; other site
1097668005031	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1097668005032	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1097668005033	putative NAD(P) binding site [chemical binding]; other site
1097668005034	dimer interface [polypeptide binding]; other site
1097668005035	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668005036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668005037	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668005038	putative effector binding pocket; other site
1097668005039	dimerization interface [polypeptide binding]; other site
1097668005040	Domain of unknown function (DUF4072); Region: DUF4072; pfam13284
1097668005041	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1097668005042	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668005043	motif II; other site
1097668005044	cystathionine beta-lyase; Provisional; Region: PRK07050
1097668005045	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097668005046	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668005047	catalytic residue [active]
1097668005048	beta-ketothiolase; Provisional; Region: PRK09051
1097668005049	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668005050	dimer interface [polypeptide binding]; other site
1097668005051	active site
1097668005052	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097668005053	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1097668005054	substrate binding site [chemical binding]; other site
1097668005055	ATP binding site [chemical binding]; other site
1097668005056	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1097668005057	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1097668005058	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668005059	FeS/SAM binding site; other site
1097668005060	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
1097668005061	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
1097668005062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
1097668005063	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
1097668005064	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
1097668005065	acetyacetyl-CoA reductase; Provisional; Region: PRK12938
1097668005066	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1097668005067	NAD(P) binding site [chemical binding]; other site
1097668005068	homotetramer interface [polypeptide binding]; other site
1097668005069	homodimer interface [polypeptide binding]; other site
1097668005070	active site
1097668005071	putative acyltransferase; Provisional; Region: PRK05790
1097668005072	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668005073	dimer interface [polypeptide binding]; other site
1097668005074	active site
1097668005075	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
1097668005076	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1097668005077	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1097668005078	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1097668005079	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1097668005080	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668005081	RNA binding surface [nucleotide binding]; other site
1097668005082	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1097668005083	active site
1097668005084	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1097668005085	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1097668005086	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1097668005087	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1097668005088	Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262
1097668005089	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1097668005090	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1097668005091	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1097668005092	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1097668005093	RNA binding site [nucleotide binding]; other site
1097668005094	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1097668005095	potassium uptake protein; Region: kup; TIGR00794
1097668005096	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
1097668005097	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668005098	active site
1097668005099	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1097668005100	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1097668005101	GDP-binding site [chemical binding]; other site
1097668005102	ACT binding site; other site
1097668005103	IMP binding site; other site
1097668005104	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
1097668005105	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1097668005106	dimer interface [polypeptide binding]; other site
1097668005107	motif 1; other site
1097668005108	active site
1097668005109	motif 2; other site
1097668005110	motif 3; other site
1097668005111	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
1097668005112	HflC protein; Region: hflC; TIGR01932
1097668005113	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1097668005114	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1097668005115	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1097668005116	HflK protein; Region: hflK; TIGR01933
1097668005117	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1097668005118	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1097668005119	HflX GTPase family; Region: HflX; cd01878
1097668005120	G1 box; other site
1097668005121	GTP/Mg2+ binding site [chemical binding]; other site
1097668005122	Switch I region; other site
1097668005123	G2 box; other site
1097668005124	G3 box; other site
1097668005125	Switch II region; other site
1097668005126	G4 box; other site
1097668005127	G5 box; other site
1097668005128	bacterial Hfq-like; Region: Hfq; cd01716
1097668005129	hexamer interface [polypeptide binding]; other site
1097668005130	Sm1 motif; other site
1097668005131	RNA binding site [nucleotide binding]; other site
1097668005132	Sm2 motif; other site
1097668005133	GTP-binding protein Der; Reviewed; Region: PRK00093
1097668005134	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1097668005135	G1 box; other site
1097668005136	GTP/Mg2+ binding site [chemical binding]; other site
1097668005137	Switch I region; other site
1097668005138	G2 box; other site
1097668005139	Switch II region; other site
1097668005140	G3 box; other site
1097668005141	G4 box; other site
1097668005142	G5 box; other site
1097668005143	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1097668005144	G1 box; other site
1097668005145	GTP/Mg2+ binding site [chemical binding]; other site
1097668005146	Switch I region; other site
1097668005147	G2 box; other site
1097668005148	G3 box; other site
1097668005149	Switch II region; other site
1097668005150	G4 box; other site
1097668005151	G5 box; other site
1097668005152	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
1097668005153	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1097668005154	Trp docking motif [polypeptide binding]; other site
1097668005155	active site
1097668005156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1097668005157	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1097668005158	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1097668005159	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1097668005160	dimer interface [polypeptide binding]; other site
1097668005161	motif 1; other site
1097668005162	active site
1097668005163	motif 2; other site
1097668005164	motif 3; other site
1097668005165	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1097668005166	anticodon binding site; other site
1097668005167	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1097668005168	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1097668005169	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1097668005170	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668005171	non-specific DNA binding site [nucleotide binding]; other site
1097668005172	salt bridge; other site
1097668005173	sequence-specific DNA binding site [nucleotide binding]; other site
1097668005174	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1097668005175	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1097668005176	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668005177	FeS/SAM binding site; other site
1097668005178	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1097668005179	active site
1097668005180	multimer interface [polypeptide binding]; other site
1097668005181	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1097668005182	YccA-like proteins; Region: YccA_like; cd10433
1097668005183	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1097668005184	TRAM domain; Region: TRAM; cl01282
1097668005185	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668005186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668005187	S-adenosylmethionine binding site [chemical binding]; other site
1097668005188	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
1097668005189	active site
1097668005190	catalytic site [active]
1097668005191	substrate binding site [chemical binding]; other site
1097668005192	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
1097668005193	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
1097668005194	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1097668005195	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668005196	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668005197	DNA binding residues [nucleotide binding]
1097668005198	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1097668005199	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097668005200	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097668005201	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1097668005202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668005203	S-adenosylmethionine binding site [chemical binding]; other site
1097668005204	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1097668005205	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097668005206	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1097668005207	NAD(P) binding site [chemical binding]; other site
1097668005208	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1097668005209	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668005210	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668005211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668005212	dimer interface [polypeptide binding]; other site
1097668005213	conserved gate region; other site
1097668005214	putative PBP binding loops; other site
1097668005215	ABC-ATPase subunit interface; other site
1097668005216	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668005217	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668005218	Walker A/P-loop; other site
1097668005219	ATP binding site [chemical binding]; other site
1097668005220	Q-loop/lid; other site
1097668005221	ABC transporter signature motif; other site
1097668005222	Walker B; other site
1097668005223	D-loop; other site
1097668005224	H-loop/switch region; other site
1097668005225	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668005226	NMT1-like family; Region: NMT1_2; pfam13379
1097668005227	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668005228	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668005229	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1097668005230	recombination protein RecR; Reviewed; Region: recR; PRK00076
1097668005231	RecR protein; Region: RecR; pfam02132
1097668005232	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1097668005233	putative active site [active]
1097668005234	putative metal-binding site [ion binding]; other site
1097668005235	tetramer interface [polypeptide binding]; other site
1097668005236	hypothetical protein; Validated; Region: PRK00153
1097668005237	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1097668005238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668005239	Walker A motif; other site
1097668005240	ATP binding site [chemical binding]; other site
1097668005241	Walker B motif; other site
1097668005242	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1097668005243	arginine finger; other site
1097668005244	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1097668005245	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1097668005246	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668005247	catalytic residues [active]
1097668005248	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1097668005249	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1097668005250	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1097668005251	RNA binding site [nucleotide binding]; other site
1097668005252	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1097668005253	multimer interface [polypeptide binding]; other site
1097668005254	Walker A motif; other site
1097668005255	ATP binding site [chemical binding]; other site
1097668005256	Walker B motif; other site
1097668005257	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
1097668005258	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1097668005259	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1097668005260	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1097668005261	multidrug efflux protein; Reviewed; Region: PRK01766
1097668005262	cation binding site [ion binding]; other site
1097668005263	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1097668005264	MG2 domain; Region: A2M_N; pfam01835
1097668005265	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1097668005266	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
1097668005267	Transglycosylase; Region: Transgly; pfam00912
1097668005268	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1097668005269	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1097668005270	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1097668005271	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
1097668005272	putative transposase OrfB; Reviewed; Region: PHA02517
1097668005273	HTH-like domain; Region: HTH_21; pfam13276
1097668005274	Integrase core domain; Region: rve; pfam00665
1097668005275	Integrase core domain; Region: rve_2; pfam13333
1097668005276	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668005277	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668005278	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668005279	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1097668005280	Clp amino terminal domain; Region: Clp_N; pfam02861
1097668005281	Clp amino terminal domain; Region: Clp_N; pfam02861
1097668005282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668005283	Walker A motif; other site
1097668005284	ATP binding site [chemical binding]; other site
1097668005285	Walker B motif; other site
1097668005286	arginine finger; other site
1097668005287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668005288	Walker A motif; other site
1097668005289	ATP binding site [chemical binding]; other site
1097668005290	Walker B motif; other site
1097668005291	arginine finger; other site
1097668005292	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1097668005293	Rrf2 family protein; Region: rrf2_super; TIGR00738
1097668005294	Transcriptional regulator; Region: Rrf2; cl17282
1097668005295	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1097668005296	apolar tunnel; other site
1097668005297	heme binding site [chemical binding]; other site
1097668005298	dimerization interface [polypeptide binding]; other site
1097668005299	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1097668005300	MoaE homodimer interface [polypeptide binding]; other site
1097668005301	MoaD interaction [polypeptide binding]; other site
1097668005302	active site residues [active]
1097668005303	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1097668005304	MoaE interaction surface [polypeptide binding]; other site
1097668005305	MoeB interaction surface [polypeptide binding]; other site
1097668005306	thiocarboxylated glycine; other site
1097668005307	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1097668005308	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1097668005309	dimer interface [polypeptide binding]; other site
1097668005310	putative functional site; other site
1097668005311	putative MPT binding site; other site
1097668005312	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511
1097668005313	nudix motif; other site
1097668005314	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1097668005315	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1097668005316	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1097668005317	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1097668005318	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1097668005319	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1097668005320	quinone interaction residues [chemical binding]; other site
1097668005321	active site
1097668005322	catalytic residues [active]
1097668005323	FMN binding site [chemical binding]; other site
1097668005324	substrate binding site [chemical binding]; other site
1097668005325	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668005326	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668005327	substrate binding pocket [chemical binding]; other site
1097668005328	membrane-bound complex binding site; other site
1097668005329	hinge residues; other site
1097668005330	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668005331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668005332	dimer interface [polypeptide binding]; other site
1097668005333	conserved gate region; other site
1097668005334	putative PBP binding loops; other site
1097668005335	ABC-ATPase subunit interface; other site
1097668005336	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668005337	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668005338	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668005339	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668005340	DNA-binding site [nucleotide binding]; DNA binding site
1097668005341	FCD domain; Region: FCD; pfam07729
1097668005342	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668005343	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1097668005344	putative ADP-binding pocket [chemical binding]; other site
1097668005345	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097668005346	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
1097668005347	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668005348	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
1097668005349	ligand binding site [chemical binding]; other site
1097668005350	flexible hinge region; other site
1097668005351	putative switch regulator; other site
1097668005352	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1097668005353	non-specific DNA interactions [nucleotide binding]; other site
1097668005354	DNA binding site [nucleotide binding]
1097668005355	sequence specific DNA binding site [nucleotide binding]; other site
1097668005356	putative cAMP binding site [chemical binding]; other site
1097668005357	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1097668005358	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1097668005359	Predicted transcriptional regulators [Transcription]; Region: COG1695
1097668005360	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1097668005361	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1097668005362	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1097668005363	active site
1097668005364	dimer interface [polypeptide binding]; other site
1097668005365	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
1097668005366	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1097668005367	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1097668005368	amidase catalytic site [active]
1097668005369	Zn binding residues [ion binding]; other site
1097668005370	substrate binding site [chemical binding]; other site
1097668005371	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1097668005372	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1097668005373	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1097668005374	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1097668005375	ribonuclease R; Region: RNase_R; TIGR02063
1097668005376	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1097668005377	RNB domain; Region: RNB; pfam00773
1097668005378	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1097668005379	RNA binding site [nucleotide binding]; other site
1097668005380	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1097668005381	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668005382	active site
1097668005383	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1097668005384	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1097668005385	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668005386	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668005387	NAD(P) binding site [chemical binding]; other site
1097668005388	active site
1097668005389	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668005390	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668005391	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1097668005392	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668005393	dimer interface [polypeptide binding]; other site
1097668005394	active site
1097668005395	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1097668005396	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1097668005397	acyl-activating enzyme (AAE) consensus motif; other site
1097668005398	putative AMP binding site [chemical binding]; other site
1097668005399	putative active site [active]
1097668005400	putative CoA binding site [chemical binding]; other site
1097668005401	Protein of unknown function (DUF1571); Region: DUF1571; pfam07608
1097668005402	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1097668005403	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1097668005404	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1097668005405	Predicted ATPase [General function prediction only]; Region: COG1485
1097668005406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668005407	Walker B; other site
1097668005408	D-loop; other site
1097668005409	H-loop/switch region; other site
1097668005410	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1097668005411	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668005412	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668005413	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1097668005414	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668005415	E3 interaction surface; other site
1097668005416	lipoyl attachment site [posttranslational modification]; other site
1097668005417	e3 binding domain; Region: E3_binding; pfam02817
1097668005418	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1097668005419	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1097668005420	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1097668005421	TPP-binding site [chemical binding]; other site
1097668005422	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1097668005423	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1097668005424	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1097668005425	G1 box; other site
1097668005426	putative GEF interaction site [polypeptide binding]; other site
1097668005427	GTP/Mg2+ binding site [chemical binding]; other site
1097668005428	Switch I region; other site
1097668005429	G2 box; other site
1097668005430	G3 box; other site
1097668005431	Switch II region; other site
1097668005432	G4 box; other site
1097668005433	G5 box; other site
1097668005434	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1097668005435	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1097668005436	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668005437	MarR family; Region: MarR_2; pfam12802
1097668005438	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668005439	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
1097668005440	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668005441	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668005442	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668005443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668005444	putative substrate translocation pore; other site
1097668005445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668005446	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
1097668005447	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668005448	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1097668005449	arsenical-resistance protein; Region: acr3; TIGR00832
1097668005450	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668005451	putative DNA binding site [nucleotide binding]; other site
1097668005452	putative Zn2+ binding site [ion binding]; other site
1097668005453	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851
1097668005454	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1097668005455	RNA binding site [nucleotide binding]; other site
1097668005456	active site
1097668005457	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1097668005458	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1097668005459	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1097668005460	translation initiation factor IF-2; Region: IF-2; TIGR00487
1097668005461	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1097668005462	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1097668005463	G1 box; other site
1097668005464	putative GEF interaction site [polypeptide binding]; other site
1097668005465	GTP/Mg2+ binding site [chemical binding]; other site
1097668005466	Switch I region; other site
1097668005467	G2 box; other site
1097668005468	G3 box; other site
1097668005469	Switch II region; other site
1097668005470	G4 box; other site
1097668005471	G5 box; other site
1097668005472	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1097668005473	Translation-initiation factor 2; Region: IF-2; pfam11987
1097668005474	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1097668005475	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1097668005476	NusA N-terminal domain; Region: NusA_N; pfam08529
1097668005477	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1097668005478	RNA binding site [nucleotide binding]; other site
1097668005479	homodimer interface [polypeptide binding]; other site
1097668005480	NusA-like KH domain; Region: KH_5; pfam13184
1097668005481	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1097668005482	G-X-X-G motif; other site
1097668005483	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1097668005484	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1097668005485	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1097668005486	hypothetical protein; Provisional; Region: PRK14641
1097668005487	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1097668005488	putative oligomer interface [polypeptide binding]; other site
1097668005489	putative RNA binding site [nucleotide binding]; other site
1097668005490	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1097668005491	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668005492	RNA binding surface [nucleotide binding]; other site
1097668005493	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1097668005494	probable active site [active]
1097668005495	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1097668005496	aspartate aminotransferase; Provisional; Region: PRK06108
1097668005497	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668005498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668005499	homodimer interface [polypeptide binding]; other site
1097668005500	catalytic residue [active]
1097668005501	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668005502	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668005503	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1097668005504	putative dimerization interface [polypeptide binding]; other site
1097668005505	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
1097668005506	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1097668005507	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1097668005508	putative active site [active]
1097668005509	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1097668005510	putative active site pocket [active]
1097668005511	dimerization interface [polypeptide binding]; other site
1097668005512	putative catalytic residue [active]
1097668005513	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1097668005514	Helix-turn-helix domain; Region: HTH_18; pfam12833
1097668005515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668005516	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668005517	Coenzyme A binding pocket [chemical binding]; other site
1097668005518	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1097668005519	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1097668005520	HIGH motif; other site
1097668005521	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1097668005522	active site
1097668005523	KMSKS motif; other site
1097668005524	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1097668005525	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1097668005526	nucleophile elbow; other site
1097668005527	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668005528	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668005529	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668005530	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668005531	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668005532	4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194
1097668005533	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668005534	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668005535	Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384
1097668005536	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668005537	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668005538	catalytic loop [active]
1097668005539	iron binding site [ion binding]; other site
1097668005540	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1097668005541	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1097668005542	nucleotide binding site [chemical binding]; other site
1097668005543	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1097668005544	SBD interface [polypeptide binding]; other site
1097668005545	co-chaperone HscB; Provisional; Region: hscB; PRK03578
1097668005546	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1097668005547	HSP70 interaction site [polypeptide binding]; other site
1097668005548	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1097668005549	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1097668005550	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1097668005551	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1097668005552	trimerization site [polypeptide binding]; other site
1097668005553	active site
1097668005554	cysteine desulfurase; Provisional; Region: PRK14012
1097668005555	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1097668005556	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668005557	catalytic residue [active]
1097668005558	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
1097668005559	Rrf2 family protein; Region: rrf2_super; TIGR00738
1097668005560	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1097668005561	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1097668005562	active site
1097668005563	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1097668005564	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1097668005565	nucleophile elbow; other site
1097668005566	Patatin phospholipase; Region: DUF3734; pfam12536
1097668005567	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
1097668005568	classical (c) SDRs; Region: SDR_c; cd05233
1097668005569	NAD(P) binding site [chemical binding]; other site
1097668005570	active site
1097668005571	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1097668005572	Domain of unknown function (DUF305); Region: DUF305; cl17794
1097668005573	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
1097668005574	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1097668005575	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1097668005576	DNA binding residues [nucleotide binding]
1097668005577	dimer interface [polypeptide binding]; other site
1097668005578	copper binding site [ion binding]; other site
1097668005579	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1097668005580	metal-binding site [ion binding]
1097668005581	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1097668005582	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1097668005583	NADP binding site [chemical binding]; other site
1097668005584	active site
1097668005585	putative substrate binding site [chemical binding]; other site
1097668005586	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1097668005587	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1097668005588	putative active site [active]
1097668005589	putative PHP Thumb interface [polypeptide binding]; other site
1097668005590	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1097668005591	generic binding surface II; other site
1097668005592	generic binding surface I; other site
1097668005593	DNA Polymerase Y-family; Region: PolY_like; cd03468
1097668005594	active site
1097668005595	DNA binding site [nucleotide binding]
1097668005596	Uncharacterized conserved protein [Function unknown]; Region: COG4544
1097668005597	Protein of unknown function (DUF2863); Region: DUF2863; pfam11062
1097668005598	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668005599	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668005600	DNA binding residues [nucleotide binding]
1097668005601	Predicted membrane protein [Function unknown]; Region: COG3235
1097668005602	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1097668005603	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
1097668005604	putative active site [active]
1097668005605	Zn binding site [ion binding]; other site
1097668005606	hypothetical protein; Validated; Region: PRK02101
1097668005607	PIN domain; Region: PIN_3; pfam13470
1097668005608	methionine aminotransferase; Validated; Region: PRK09082
1097668005609	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668005610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668005611	homodimer interface [polypeptide binding]; other site
1097668005612	catalytic residue [active]
1097668005613	3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268
1097668005614	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668005615	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668005616	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668005617	enoyl-CoA hydratase; Provisional; Region: PRK07511
1097668005618	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668005619	substrate binding site [chemical binding]; other site
1097668005620	oxyanion hole (OAH) forming residues; other site
1097668005621	trimer interface [polypeptide binding]; other site
1097668005622	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097668005623	catalytic core [active]
1097668005624	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1097668005625	putative active site [active]
1097668005626	putative substrate binding site [chemical binding]; other site
1097668005627	ATP binding site [chemical binding]; other site
1097668005628	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668005629	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
1097668005630	FAD binding site [chemical binding]; other site
1097668005631	substrate binding site [chemical binding]; other site
1097668005632	catalytic base [active]
1097668005633	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
1097668005634	putative active site [active]
1097668005635	putative catalytic site [active]
1097668005636	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
1097668005637	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1097668005638	dimer interface [polypeptide binding]; other site
1097668005639	ADP-ribose binding site [chemical binding]; other site
1097668005640	active site
1097668005641	nudix motif; other site
1097668005642	metal binding site [ion binding]; metal-binding site
1097668005643	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
1097668005644	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1097668005645	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1097668005646	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1097668005647	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1097668005648	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1097668005649	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1097668005650	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1097668005651	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1097668005652	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1097668005653	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1097668005654	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1097668005655	4Fe-4S binding domain; Region: Fer4; pfam00037
1097668005656	4Fe-4S binding domain; Region: Fer4; pfam00037
1097668005657	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1097668005658	NADH dehydrogenase subunit G; Validated; Region: PRK09129
1097668005659	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668005660	catalytic loop [active]
1097668005661	iron binding site [ion binding]; other site
1097668005662	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1097668005663	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
1097668005664	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1097668005665	SLBB domain; Region: SLBB; pfam10531
1097668005666	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1097668005667	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1097668005668	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1097668005669	putative dimer interface [polypeptide binding]; other site
1097668005670	[2Fe-2S] cluster binding site [ion binding]; other site
1097668005671	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1097668005672	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1097668005673	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
1097668005674	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1097668005675	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1097668005676	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1097668005677	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1097668005678	triosephosphate isomerase; Provisional; Region: PRK14567
1097668005679	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1097668005680	substrate binding site [chemical binding]; other site
1097668005681	dimer interface [polypeptide binding]; other site
1097668005682	catalytic triad [active]
1097668005683	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1097668005684	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1097668005685	NAD(P) binding site [chemical binding]; other site
1097668005686	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1097668005687	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1097668005688	RNase E interface [polypeptide binding]; other site
1097668005689	trimer interface [polypeptide binding]; other site
1097668005690	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1097668005691	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1097668005692	RNase E interface [polypeptide binding]; other site
1097668005693	trimer interface [polypeptide binding]; other site
1097668005694	active site
1097668005695	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1097668005696	putative nucleic acid binding region [nucleotide binding]; other site
1097668005697	G-X-X-G motif; other site
1097668005698	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1097668005699	RNA binding site [nucleotide binding]; other site
1097668005700	domain interface; other site
1097668005701	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1097668005702	16S/18S rRNA binding site [nucleotide binding]; other site
1097668005703	S13e-L30e interaction site [polypeptide binding]; other site
1097668005704	25S rRNA binding site [nucleotide binding]; other site
1097668005705	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668005706	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
1097668005707	putative ligand binding site [chemical binding]; other site
1097668005708	Transposase domain (DUF772); Region: DUF772; pfam05598
1097668005709	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1097668005710	2-isopropylmalate synthase; Validated; Region: PRK00915
1097668005711	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1097668005712	active site
1097668005713	catalytic residues [active]
1097668005714	metal binding site [ion binding]; metal-binding site
1097668005715	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1097668005716	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1097668005717	NlpC/P60 family; Region: NLPC_P60; pfam00877
1097668005718	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1097668005719	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668005720	Walker A/P-loop; other site
1097668005721	ATP binding site [chemical binding]; other site
1097668005722	Q-loop/lid; other site
1097668005723	ABC transporter signature motif; other site
1097668005724	Walker B; other site
1097668005725	D-loop; other site
1097668005726	H-loop/switch region; other site
1097668005727	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668005728	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668005729	Walker A/P-loop; other site
1097668005730	ATP binding site [chemical binding]; other site
1097668005731	Q-loop/lid; other site
1097668005732	ABC transporter signature motif; other site
1097668005733	Walker B; other site
1097668005734	D-loop; other site
1097668005735	H-loop/switch region; other site
1097668005736	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668005737	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1097668005738	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1097668005739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668005740	dimer interface [polypeptide binding]; other site
1097668005741	conserved gate region; other site
1097668005742	putative PBP binding loops; other site
1097668005743	ABC-ATPase subunit interface; other site
1097668005744	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1097668005745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668005746	dimer interface [polypeptide binding]; other site
1097668005747	conserved gate region; other site
1097668005748	putative PBP binding loops; other site
1097668005749	ABC-ATPase subunit interface; other site
1097668005750	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1097668005751	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1097668005752	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997
1097668005753	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1097668005754	NAD binding site [chemical binding]; other site
1097668005755	homotetramer interface [polypeptide binding]; other site
1097668005756	homodimer interface [polypeptide binding]; other site
1097668005757	substrate binding site [chemical binding]; other site
1097668005758	active site
1097668005759	benzoate transport; Region: 2A0115; TIGR00895
1097668005760	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668005761	putative substrate translocation pore; other site
1097668005762	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668005763	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668005764	DNA-binding site [nucleotide binding]; DNA binding site
1097668005765	FCD domain; Region: FCD; pfam07729
1097668005766	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
1097668005767	Coenzyme A transferase; Region: CoA_trans; cl17247
1097668005768	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1097668005769	triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237
1097668005770	malonate decarboxylase subunit delta; Provisional; Region: PRK01220
1097668005771	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1097668005772	malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134
1097668005773	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
1097668005774	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1097668005775	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
1097668005776	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1097668005777	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1097668005778	aspartate kinase; Reviewed; Region: PRK06635
1097668005779	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1097668005780	putative nucleotide binding site [chemical binding]; other site
1097668005781	putative catalytic residues [active]
1097668005782	putative Mg ion binding site [ion binding]; other site
1097668005783	putative aspartate binding site [chemical binding]; other site
1097668005784	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1097668005785	putative allosteric regulatory site; other site
1097668005786	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1097668005787	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1097668005788	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1097668005789	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1097668005790	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1097668005791	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1097668005792	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1097668005793	endonuclease III; Region: ENDO3c; smart00478
1097668005794	minor groove reading motif; other site
1097668005795	helix-hairpin-helix signature motif; other site
1097668005796	substrate binding pocket [chemical binding]; other site
1097668005797	active site
1097668005798	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1097668005799	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1097668005800	active site
1097668005801	HIGH motif; other site
1097668005802	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1097668005803	KMSKS motif; other site
1097668005804	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1097668005805	tRNA binding surface [nucleotide binding]; other site
1097668005806	anticodon binding site; other site
1097668005807	TPR repeat; Region: TPR_11; pfam13414
1097668005808	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668005809	binding surface
1097668005810	TPR motif; other site
1097668005811	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1097668005812	active site
1097668005813	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1097668005814	substrate binding site [chemical binding]; other site
1097668005815	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1097668005816	putative active site [active]
1097668005817	putative metal binding site [ion binding]; other site
1097668005818	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1097668005819	serine O-acetyltransferase; Region: cysE; TIGR01172
1097668005820	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1097668005821	trimer interface [polypeptide binding]; other site
1097668005822	active site
1097668005823	substrate binding site [chemical binding]; other site
1097668005824	CoA binding site [chemical binding]; other site
1097668005825	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1097668005826	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1097668005827	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1097668005828	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1097668005829	active site
1097668005830	dimerization interface [polypeptide binding]; other site
1097668005831	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1097668005832	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1097668005833	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1097668005834	MutS domain I; Region: MutS_I; pfam01624
1097668005835	MutS domain II; Region: MutS_II; pfam05188
1097668005836	MutS domain III; Region: MutS_III; pfam05192
1097668005837	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1097668005838	Walker A/P-loop; other site
1097668005839	ATP binding site [chemical binding]; other site
1097668005840	Q-loop/lid; other site
1097668005841	ABC transporter signature motif; other site
1097668005842	Walker B; other site
1097668005843	D-loop; other site
1097668005844	H-loop/switch region; other site
1097668005845	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
1097668005846	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1097668005847	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1097668005848	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
1097668005849	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
1097668005850	ATP binding site [chemical binding]; other site
1097668005851	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1097668005852	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1097668005853	dimer interface [polypeptide binding]; other site
1097668005854	active site
1097668005855	catalytic residue [active]
1097668005856	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1097668005857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668005858	S-adenosylmethionine binding site [chemical binding]; other site
1097668005859	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1097668005860	active site
1097668005861	HIGH motif; other site
1097668005862	dimer interface [polypeptide binding]; other site
1097668005863	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097668005864	active site
1097668005865	KMSKS motif; other site
1097668005866	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1097668005867	Peptidase family M50; Region: Peptidase_M50; pfam02163
1097668005868	active site
1097668005869	putative substrate binding region [chemical binding]; other site
1097668005870	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1097668005871	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1097668005872	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1097668005873	active site
1097668005874	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1097668005875	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668005876	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668005877	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1097668005878	dinuclear metal binding motif [ion binding]; other site
1097668005879	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1097668005880	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1097668005881	trimer interface [polypeptide binding]; other site
1097668005882	putative metal binding site [ion binding]; other site
1097668005883	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1097668005884	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1097668005885	dimerization interface [polypeptide binding]; other site
1097668005886	domain crossover interface; other site
1097668005887	redox-dependent activation switch; other site
1097668005888	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
1097668005889	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1097668005890	enolase; Provisional; Region: eno; PRK00077
1097668005891	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1097668005892	dimer interface [polypeptide binding]; other site
1097668005893	metal binding site [ion binding]; metal-binding site
1097668005894	substrate binding pocket [chemical binding]; other site
1097668005895	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1097668005896	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1097668005897	CTP synthetase; Validated; Region: pyrG; PRK05380
1097668005898	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1097668005899	Catalytic site [active]
1097668005900	active site
1097668005901	UTP binding site [chemical binding]; other site
1097668005902	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1097668005903	active site
1097668005904	putative oxyanion hole; other site
1097668005905	catalytic triad [active]
1097668005906	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668005907	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1097668005908	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1097668005909	Competence protein; Region: Competence; pfam03772
1097668005910	Competence protein; Region: Competence; pfam03772
1097668005911	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1097668005912	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668005913	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1097668005914	active site
1097668005915	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1097668005916	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1097668005917	Walker A/P-loop; other site
1097668005918	ATP binding site [chemical binding]; other site
1097668005919	Q-loop/lid; other site
1097668005920	ABC transporter signature motif; other site
1097668005921	Walker B; other site
1097668005922	D-loop; other site
1097668005923	H-loop/switch region; other site
1097668005924	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1097668005925	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1097668005926	FtsX-like permease family; Region: FtsX; pfam02687
1097668005927	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
1097668005928	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1097668005929	DHH family; Region: DHH; pfam01368
1097668005930	DHHA1 domain; Region: DHHA1; pfam02272
1097668005931	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1097668005932	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1097668005933	RF-1 domain; Region: RF-1; pfam00472
1097668005934	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1097668005935	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1097668005936	dimer interface [polypeptide binding]; other site
1097668005937	putative anticodon binding site; other site
1097668005938	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1097668005939	motif 1; other site
1097668005940	active site
1097668005941	motif 2; other site
1097668005942	motif 3; other site
1097668005943	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1097668005944	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1097668005945	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1097668005946	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
1097668005947	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1097668005948	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1097668005949	putative active site [active]
1097668005950	putative NTP binding site [chemical binding]; other site
1097668005951	putative nucleic acid binding site [nucleotide binding]; other site
1097668005952	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1097668005953	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1097668005954	active site
1097668005955	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1097668005956	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1097668005957	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1097668005958	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1097668005959	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1097668005960	putative valine binding site [chemical binding]; other site
1097668005961	dimer interface [polypeptide binding]; other site
1097668005962	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1097668005963	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
1097668005964	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668005965	PYR/PP interface [polypeptide binding]; other site
1097668005966	dimer interface [polypeptide binding]; other site
1097668005967	TPP binding site [chemical binding]; other site
1097668005968	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668005969	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1097668005970	TPP-binding site [chemical binding]; other site
1097668005971	dimer interface [polypeptide binding]; other site
1097668005972	RNA polymerase factor sigma-70; Validated; Region: PRK09047
1097668005973	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668005974	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668005975	DNA binding residues [nucleotide binding]
1097668005976	Protein of unknown function (DUF3619); Region: DUF3619; pfam12279
1097668005977	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
1097668005978	RDD family; Region: RDD; pfam06271
1097668005979	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1097668005980	putative active site [active]
1097668005981	putative metal binding site [ion binding]; other site
1097668005982	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668005983	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1097668005984	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1097668005985	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668005986	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668005987	Bacterial transcriptional repressor; Region: TetR; pfam13972
1097668005988	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1097668005989	glucose-1-dehydrogenase; Provisional; Region: PRK06947
1097668005990	classical (c) SDRs; Region: SDR_c; cd05233
1097668005991	NAD(P) binding site [chemical binding]; other site
1097668005992	active site
1097668005993	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
1097668005994	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1097668005995	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1097668005996	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1097668005997	apolar tunnel; other site
1097668005998	heme binding site [chemical binding]; other site
1097668005999	dimerization interface [polypeptide binding]; other site
1097668006000	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1097668006001	FtsX-like permease family; Region: FtsX; pfam02687
1097668006002	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
1097668006003	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1097668006004	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1097668006005	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1097668006006	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1097668006007	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1097668006008	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1097668006009	catalytic triad [active]
1097668006010	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1097668006011	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668006012	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668006013	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668006014	metal binding site [ion binding]; metal-binding site
1097668006015	active site
1097668006016	I-site; other site
1097668006017	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668006018	HDOD domain; Region: HDOD; pfam08668
1097668006019	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1097668006020	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1097668006021	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668006022	dimer interface [polypeptide binding]; other site
1097668006023	putative CheW interface [polypeptide binding]; other site
1097668006024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668006025	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668006026	putative substrate translocation pore; other site
1097668006027	Fimbrial protein; Region: Fimbrial; cl01416
1097668006028	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1097668006029	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668006030	acyl-activating enzyme (AAE) consensus motif; other site
1097668006031	AMP binding site [chemical binding]; other site
1097668006032	active site
1097668006033	CoA binding site [chemical binding]; other site
1097668006034	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1097668006035	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1097668006036	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1097668006037	Part of AAA domain; Region: AAA_19; pfam13245
1097668006038	Family description; Region: UvrD_C_2; pfam13538
1097668006039	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1097668006040	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1097668006041	HIGH motif; other site
1097668006042	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1097668006043	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1097668006044	active site
1097668006045	KMSKS motif; other site
1097668006046	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1097668006047	tRNA binding surface [nucleotide binding]; other site
1097668006048	anticodon binding site; other site
1097668006049	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1097668006050	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1097668006051	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1097668006052	active site
1097668006053	tetramer interface; other site
1097668006054	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1097668006055	CPxP  motif; other site
1097668006056	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668006057	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668006058	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668006059	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668006060	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668006061	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668006062	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097668006063	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097668006064	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097668006065	putative active site [active]
1097668006066	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1097668006067	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668006068	putative ligand binding site [chemical binding]; other site
1097668006069	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668006070	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668006071	TM-ABC transporter signature motif; other site
1097668006072	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668006073	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668006074	Walker A/P-loop; other site
1097668006075	ATP binding site [chemical binding]; other site
1097668006076	Q-loop/lid; other site
1097668006077	ABC transporter signature motif; other site
1097668006078	Walker B; other site
1097668006079	D-loop; other site
1097668006080	H-loop/switch region; other site
1097668006081	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097668006082	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1097668006083	substrate binding site [chemical binding]; other site
1097668006084	ATP binding site [chemical binding]; other site
1097668006085	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1097668006086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1097668006087	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1097668006088	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668006089	PYR/PP interface [polypeptide binding]; other site
1097668006090	dimer interface [polypeptide binding]; other site
1097668006091	TPP binding site [chemical binding]; other site
1097668006092	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668006093	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1097668006094	TPP-binding site; other site
1097668006095	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1097668006096	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1097668006097	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668006098	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668006099	Walker A/P-loop; other site
1097668006100	ATP binding site [chemical binding]; other site
1097668006101	Q-loop/lid; other site
1097668006102	ABC transporter signature motif; other site
1097668006103	Walker B; other site
1097668006104	D-loop; other site
1097668006105	H-loop/switch region; other site
1097668006106	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668006107	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668006108	Walker A/P-loop; other site
1097668006109	ATP binding site [chemical binding]; other site
1097668006110	Q-loop/lid; other site
1097668006111	ABC transporter signature motif; other site
1097668006112	Walker B; other site
1097668006113	D-loop; other site
1097668006114	H-loop/switch region; other site
1097668006115	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668006116	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668006117	TM-ABC transporter signature motif; other site
1097668006118	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668006119	TM-ABC transporter signature motif; other site
1097668006120	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097668006121	active site
1097668006122	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1097668006123	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1097668006124	tetramer interface [polypeptide binding]; other site
1097668006125	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668006126	catalytic residue [active]
1097668006127	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1097668006128	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1097668006129	motif 1; other site
1097668006130	active site
1097668006131	motif 2; other site
1097668006132	motif 3; other site
1097668006133	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1097668006134	DHHA1 domain; Region: DHHA1; pfam02272
1097668006135	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668006136	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668006137	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1097668006138	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097668006139	active site
1097668006140	HIGH motif; other site
1097668006141	nucleotide binding site [chemical binding]; other site
1097668006142	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1097668006143	KMSKS motif; other site
1097668006144	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1097668006145	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1097668006146	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668006147	substrate binding pocket [chemical binding]; other site
1097668006148	membrane-bound complex binding site; other site
1097668006149	hinge residues; other site
1097668006150	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1097668006151	nudix motif; other site
1097668006152	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1097668006153	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1097668006154	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
1097668006155	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668006156	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668006157	DNA-binding site [nucleotide binding]; DNA binding site
1097668006158	FCD domain; Region: FCD; pfam07729
1097668006159	cytosine deaminase; Provisional; Region: PRK05985
1097668006160	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1097668006161	active site
1097668006162	putative cyanate transporter; Provisional; Region: cynX; PRK09705
1097668006163	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1097668006164	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1097668006165	active site
1097668006166	catalytic residues [active]
1097668006167	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097668006168	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1097668006169	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097668006170	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1097668006171	catalytic core [active]
1097668006172	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1097668006173	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1097668006174	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1097668006175	polyphosphate kinase; Provisional; Region: PRK05443
1097668006176	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1097668006177	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1097668006178	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668006179	putative active site [active]
1097668006180	catalytic site [active]
1097668006181	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1097668006182	putative domain interface [polypeptide binding]; other site
1097668006183	putative active site [active]
1097668006184	catalytic site [active]
1097668006185	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1097668006186	PAS domain; Region: PAS; smart00091
1097668006187	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668006188	dimer interface [polypeptide binding]; other site
1097668006189	phosphorylation site [posttranslational modification]
1097668006190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668006191	ATP binding site [chemical binding]; other site
1097668006192	Mg2+ binding site [ion binding]; other site
1097668006193	G-X-G motif; other site
1097668006194	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1097668006195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668006196	active site
1097668006197	phosphorylation site [posttranslational modification]
1097668006198	intermolecular recognition site; other site
1097668006199	dimerization interface [polypeptide binding]; other site
1097668006200	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668006201	DNA binding site [nucleotide binding]
1097668006202	transcriptional regulator PhoU; Provisional; Region: PRK11115
1097668006203	PhoU domain; Region: PhoU; pfam01895
1097668006204	PhoU domain; Region: PhoU; pfam01895
1097668006205	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
1097668006206	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1097668006207	Walker A/P-loop; other site
1097668006208	ATP binding site [chemical binding]; other site
1097668006209	Q-loop/lid; other site
1097668006210	ABC transporter signature motif; other site
1097668006211	Walker B; other site
1097668006212	D-loop; other site
1097668006213	H-loop/switch region; other site
1097668006214	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
1097668006215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668006216	dimer interface [polypeptide binding]; other site
1097668006217	conserved gate region; other site
1097668006218	putative PBP binding loops; other site
1097668006219	ABC-ATPase subunit interface; other site
1097668006220	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
1097668006221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668006222	dimer interface [polypeptide binding]; other site
1097668006223	conserved gate region; other site
1097668006224	putative PBP binding loops; other site
1097668006225	ABC-ATPase subunit interface; other site
1097668006226	PBP superfamily domain; Region: PBP_like_2; cl17296
1097668006227	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1097668006228	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1097668006229	active site
1097668006230	substrate binding site [chemical binding]; other site
1097668006231	metal binding site [ion binding]; metal-binding site
1097668006232	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1097668006233	dihydropteroate synthase; Region: DHPS; TIGR01496
1097668006234	substrate binding pocket [chemical binding]; other site
1097668006235	dimer interface [polypeptide binding]; other site
1097668006236	inhibitor binding site; inhibition site
1097668006237	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1097668006238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668006239	Walker A motif; other site
1097668006240	ATP binding site [chemical binding]; other site
1097668006241	Walker B motif; other site
1097668006242	arginine finger; other site
1097668006243	Peptidase family M41; Region: Peptidase_M41; pfam01434
1097668006244	FtsJ-like methyltransferase; Region: FtsJ; cl17430
1097668006245	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1097668006246	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
1097668006247	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
1097668006248	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1097668006249	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1097668006250	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1097668006251	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1097668006252	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097668006253	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1097668006254	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1097668006255	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097668006256	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668006257	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1097668006258	IMP binding site; other site
1097668006259	dimer interface [polypeptide binding]; other site
1097668006260	interdomain contacts; other site
1097668006261	partial ornithine binding site; other site
1097668006262	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1097668006263	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1097668006264	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1097668006265	catalytic site [active]
1097668006266	subunit interface [polypeptide binding]; other site
1097668006267	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668006268	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668006269	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668006270	catalytic residue [active]
1097668006271	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
1097668006272	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
1097668006273	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1097668006274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668006275	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1097668006276	RNA/DNA hybrid binding site [nucleotide binding]; other site
1097668006277	active site
1097668006278	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1097668006279	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1097668006280	active site
1097668006281	catalytic site [active]
1097668006282	substrate binding site [chemical binding]; other site
1097668006283	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
1097668006284	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1097668006285	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668006286	putative ADP-binding pocket [chemical binding]; other site
1097668006287	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1097668006288	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097668006289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668006290	Walker A/P-loop; other site
1097668006291	ATP binding site [chemical binding]; other site
1097668006292	Q-loop/lid; other site
1097668006293	ABC transporter signature motif; other site
1097668006294	Walker B; other site
1097668006295	D-loop; other site
1097668006296	H-loop/switch region; other site
1097668006297	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
1097668006298	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1097668006299	active site
1097668006300	homotetramer interface [polypeptide binding]; other site
1097668006301	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
1097668006302	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1097668006303	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1097668006304	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1097668006305	Cu(I) binding site [ion binding]; other site
1097668006306	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1097668006307	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097668006308	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1097668006309	excinuclease ABC, C subunit; Region: uvrC; TIGR00194
1097668006310	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1097668006311	GIY-YIG motif/motif A; other site
1097668006312	active site
1097668006313	catalytic site [active]
1097668006314	putative DNA binding site [nucleotide binding]; other site
1097668006315	metal binding site [ion binding]; metal-binding site
1097668006316	UvrB/uvrC motif; Region: UVR; pfam02151
1097668006317	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1097668006318	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
1097668006319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
1097668006320	elongation factor P; Validated; Region: PRK00529
1097668006321	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1097668006322	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1097668006323	RNA binding site [nucleotide binding]; other site
1097668006324	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1097668006325	RNA binding site [nucleotide binding]; other site
1097668006326	BON domain; Region: BON; pfam04972
1097668006327	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1097668006328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668006329	active site
1097668006330	phosphorylation site [posttranslational modification]
1097668006331	intermolecular recognition site; other site
1097668006332	dimerization interface [polypeptide binding]; other site
1097668006333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668006334	Walker A motif; other site
1097668006335	ATP binding site [chemical binding]; other site
1097668006336	Walker B motif; other site
1097668006337	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668006338	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1097668006339	beta-hexosaminidase; Provisional; Region: PRK05337
1097668006340	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1097668006341	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1097668006342	active site
1097668006343	hydrophilic channel; other site
1097668006344	dimerization interface [polypeptide binding]; other site
1097668006345	catalytic residues [active]
1097668006346	active site lid [active]
1097668006347	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1097668006348	Recombination protein O N terminal; Region: RecO_N; pfam11967
1097668006349	Recombination protein O C terminal; Region: RecO_C; pfam02565
1097668006350	GTPase Era; Reviewed; Region: era; PRK00089
1097668006351	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1097668006352	G1 box; other site
1097668006353	GTP/Mg2+ binding site [chemical binding]; other site
1097668006354	Switch I region; other site
1097668006355	G2 box; other site
1097668006356	Switch II region; other site
1097668006357	G3 box; other site
1097668006358	G4 box; other site
1097668006359	G5 box; other site
1097668006360	KH domain; Region: KH_2; pfam07650
1097668006361	ribonuclease III; Reviewed; Region: PRK12372
1097668006362	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1097668006363	dimerization interface [polypeptide binding]; other site
1097668006364	active site
1097668006365	metal binding site [ion binding]; metal-binding site
1097668006366	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1097668006367	signal peptidase I; Provisional; Region: PRK10861
1097668006368	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097668006369	Catalytic site [active]
1097668006370	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097668006371	GTP-binding protein LepA; Provisional; Region: PRK05433
1097668006372	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1097668006373	G1 box; other site
1097668006374	putative GEF interaction site [polypeptide binding]; other site
1097668006375	GTP/Mg2+ binding site [chemical binding]; other site
1097668006376	Switch I region; other site
1097668006377	G2 box; other site
1097668006378	G3 box; other site
1097668006379	Switch II region; other site
1097668006380	G4 box; other site
1097668006381	G5 box; other site
1097668006382	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1097668006383	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1097668006384	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1097668006385	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1097668006386	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1097668006387	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097668006388	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668006389	protein binding site [polypeptide binding]; other site
1097668006390	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668006391	protein binding site [polypeptide binding]; other site
1097668006392	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
1097668006393	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1097668006394	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1097668006395	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
1097668006396	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668006397	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668006398	DNA binding residues [nucleotide binding]
1097668006399	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1097668006400	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1097668006401	dimer interface [polypeptide binding]; other site
1097668006402	active site
1097668006403	acyl carrier protein; Provisional; Region: acpP; PRK00982
1097668006404	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668006405	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1097668006406	NAD(P) binding site [chemical binding]; other site
1097668006407	homotetramer interface [polypeptide binding]; other site
1097668006408	homodimer interface [polypeptide binding]; other site
1097668006409	active site
1097668006410	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1097668006411	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1097668006412	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1097668006413	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1097668006414	dimer interface [polypeptide binding]; other site
1097668006415	active site
1097668006416	CoA binding pocket [chemical binding]; other site
1097668006417	putative phosphate acyltransferase; Provisional; Region: PRK05331
1097668006418	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1097668006419	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1097668006420	Maf-like protein; Region: Maf; pfam02545
1097668006421	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1097668006422	active site
1097668006423	dimer interface [polypeptide binding]; other site
1097668006424	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
1097668006425	putative SAM binding site [chemical binding]; other site
1097668006426	homodimer interface [polypeptide binding]; other site
1097668006427	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
1097668006428	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1097668006429	tandem repeat interface [polypeptide binding]; other site
1097668006430	oligomer interface [polypeptide binding]; other site
1097668006431	active site residues [active]
1097668006432	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1097668006433	iron-sulfur cluster [ion binding]; other site
1097668006434	[2Fe-2S] cluster binding site [ion binding]; other site
1097668006435	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1097668006436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668006437	motif II; other site
1097668006438	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1097668006439	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1097668006440	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668006441	RNA binding surface [nucleotide binding]; other site
1097668006442	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1097668006443	active site
1097668006444	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
1097668006445	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1097668006446	homodimer interface [polypeptide binding]; other site
1097668006447	oligonucleotide binding site [chemical binding]; other site
1097668006448	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1097668006449	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668006450	FeS/SAM binding site; other site
1097668006451	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1097668006452	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1097668006453	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1097668006454	GTP binding site; other site
1097668006455	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1097668006456	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1097668006457	dimer interface [polypeptide binding]; other site
1097668006458	putative functional site; other site
1097668006459	putative MPT binding site; other site
1097668006460	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097668006461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668006462	Coenzyme A binding pocket [chemical binding]; other site
1097668006463	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1097668006464	RmuC family; Region: RmuC; pfam02646
1097668006465	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1097668006466	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1097668006467	dimerization interface [polypeptide binding]; other site
1097668006468	ligand binding site [chemical binding]; other site
1097668006469	NADP binding site [chemical binding]; other site
1097668006470	catalytic site [active]
1097668006471	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1097668006472	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1097668006473	Uncharacterized conserved protein [Function unknown]; Region: COG1556
1097668006474	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1097668006475	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1097668006476	active site
1097668006477	Ferredoxin [Energy production and conversion]; Region: COG1146
1097668006478	4Fe-4S binding domain; Region: Fer4; cl02805
1097668006479	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1097668006480	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1097668006481	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1097668006482	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1097668006483	4Fe-4S binding domain; Region: Fer4; pfam00037
1097668006484	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1097668006485	Cysteine-rich domain; Region: CCG; pfam02754
1097668006486	Cysteine-rich domain; Region: CCG; pfam02754
1097668006487	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668006488	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668006489	DNA-binding site [nucleotide binding]; DNA binding site
1097668006490	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668006491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
1097668006492	CreA protein; Region: CreA; pfam05981
1097668006493	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1097668006494	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668006495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668006496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668006497	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1097668006498	Predicted membrane protein [Function unknown]; Region: COG4392
1097668006499	Protein of unknown function (DUF4088); Region: DUF4088; pfam13317
1097668006500	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1097668006501	Part of AAA domain; Region: AAA_19; pfam13245
1097668006502	Family description; Region: UvrD_C_2; pfam13538
1097668006503	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668006504	RNA binding surface [nucleotide binding]; other site
1097668006505	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1097668006506	multidrug efflux protein; Reviewed; Region: PRK01766
1097668006507	cation binding site [ion binding]; other site
1097668006508	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1097668006509	putative active site [active]
1097668006510	catalytic site [active]
1097668006511	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1097668006512	PLD-like domain; Region: PLDc_2; pfam13091
1097668006513	putative active site [active]
1097668006514	catalytic site [active]
1097668006515	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1097668006516	Class II fumarases; Region: Fumarase_classII; cd01362
1097668006517	active site
1097668006518	tetramer interface [polypeptide binding]; other site
1097668006519	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1097668006520	oligomeric interface; other site
1097668006521	putative active site [active]
1097668006522	homodimer interface [polypeptide binding]; other site
1097668006523	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1097668006524	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1097668006525	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668006526	dimerization interface [polypeptide binding]; other site
1097668006527	putative DNA binding site [nucleotide binding]; other site
1097668006528	putative Zn2+ binding site [ion binding]; other site
1097668006529	thymidylate synthase; Provisional; Region: thyA; PRK13821
1097668006530	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1097668006531	dimerization interface [polypeptide binding]; other site
1097668006532	active site
1097668006533	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1097668006534	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668006535	Walker A motif; other site
1097668006536	ATP binding site [chemical binding]; other site
1097668006537	Walker B motif; other site
1097668006538	arginine finger; other site
1097668006539	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1097668006540	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1097668006541	folate binding site [chemical binding]; other site
1097668006542	NADP+ binding site [chemical binding]; other site
1097668006543	peptidase PmbA; Provisional; Region: PRK11040
1097668006544	hypothetical protein; Provisional; Region: PRK05255
1097668006545	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1097668006546	MPT binding site; other site
1097668006547	trimer interface [polypeptide binding]; other site
1097668006548	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1097668006549	catalytic site [active]
1097668006550	putative active site [active]
1097668006551	putative substrate binding site [chemical binding]; other site
1097668006552	dimer interface [polypeptide binding]; other site
1097668006553	Peptidase family M48; Region: Peptidase_M48; pfam01435
1097668006554	GTPase RsgA; Reviewed; Region: PRK00098
1097668006555	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1097668006556	RNA binding site [nucleotide binding]; other site
1097668006557	homodimer interface [polypeptide binding]; other site
1097668006558	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1097668006559	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1097668006560	GTP/Mg2+ binding site [chemical binding]; other site
1097668006561	G4 box; other site
1097668006562	G5 box; other site
1097668006563	G1 box; other site
1097668006564	Switch I region; other site
1097668006565	G2 box; other site
1097668006566	G3 box; other site
1097668006567	Switch II region; other site
1097668006568	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1097668006569	CobD/CbiB family protein; Provisional; Region: PRK07630
1097668006570	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1097668006571	putative active site [active]
1097668006572	putative CoA binding site [chemical binding]; other site
1097668006573	nudix motif; other site
1097668006574	metal binding site [ion binding]; metal-binding site
1097668006575	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1097668006576	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1097668006577	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1097668006578	RimM N-terminal domain; Region: RimM; pfam01782
1097668006579	PRC-barrel domain; Region: PRC; pfam05239
1097668006580	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1097668006581	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1097668006582	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668006583	FeS/SAM binding site; other site
1097668006584	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1097668006585	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668006586	putative DNA binding site [nucleotide binding]; other site
1097668006587	putative Zn2+ binding site [ion binding]; other site
1097668006588	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668006589	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1097668006590	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668006591	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668006592	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1097668006593	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1097668006594	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668006595	active site
1097668006596	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1097668006597	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668006598	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668006599	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668006600	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668006601	Ligand binding site [chemical binding]; other site
1097668006602	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668006603	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1097668006604	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1097668006605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668006606	dimer interface [polypeptide binding]; other site
1097668006607	conserved gate region; other site
1097668006608	ABC-ATPase subunit interface; other site
1097668006609	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1097668006610	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1097668006611	Walker A/P-loop; other site
1097668006612	ATP binding site [chemical binding]; other site
1097668006613	Q-loop/lid; other site
1097668006614	ABC transporter signature motif; other site
1097668006615	Walker B; other site
1097668006616	D-loop; other site
1097668006617	H-loop/switch region; other site
1097668006618	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1097668006619	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1097668006620	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668006621	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1097668006622	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
1097668006623	putative active site [active]
1097668006624	Zn binding site [ion binding]; other site
1097668006625	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1097668006626	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668006627	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668006628	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
1097668006629	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668006630	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1097668006631	cysteine synthase B; Region: cysM; TIGR01138
1097668006632	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1097668006633	dimer interface [polypeptide binding]; other site
1097668006634	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668006635	catalytic residue [active]
1097668006636	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1097668006637	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1097668006638	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
1097668006639	NADP binding site [chemical binding]; other site
1097668006640	homopentamer interface [polypeptide binding]; other site
1097668006641	substrate binding site [chemical binding]; other site
1097668006642	active site
1097668006643	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1097668006644	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1097668006645	putative ribose interaction site [chemical binding]; other site
1097668006646	putative ADP binding site [chemical binding]; other site
1097668006647	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1097668006648	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1097668006649	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1097668006650	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1097668006651	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668006652	binding surface
1097668006653	TPR motif; other site
1097668006654	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097668006655	IHF dimer interface [polypeptide binding]; other site
1097668006656	IHF - DNA interface [nucleotide binding]; other site
1097668006657	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1097668006658	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1097668006659	RNA binding site [nucleotide binding]; other site
1097668006660	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1097668006661	RNA binding site [nucleotide binding]; other site
1097668006662	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1097668006663	RNA binding site [nucleotide binding]; other site
1097668006664	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
1097668006665	RNA binding site [nucleotide binding]; other site
1097668006666	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
1097668006667	RNA binding site [nucleotide binding]; other site
1097668006668	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1097668006669	RNA binding site [nucleotide binding]; other site
1097668006670	cytidylate kinase; Provisional; Region: cmk; PRK00023
1097668006671	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1097668006672	CMP-binding site; other site
1097668006673	The sites determining sugar specificity; other site
1097668006674	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
1097668006675	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1097668006676	hinge; other site
1097668006677	active site
1097668006678	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
1097668006679	prephenate dehydrogenase; Validated; Region: PRK08507
1097668006680	Chorismate mutase type II; Region: CM_2; smart00830
1097668006681	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
1097668006682	Prephenate dehydratase; Region: PDT; pfam00800
1097668006683	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1097668006684	putative L-Phe binding site [chemical binding]; other site
1097668006685	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1097668006686	homodimer interface [polypeptide binding]; other site
1097668006687	substrate-cofactor binding pocket; other site
1097668006688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668006689	catalytic residue [active]
1097668006690	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
1097668006691	DNA gyrase subunit A; Validated; Region: PRK05560
1097668006692	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1097668006693	CAP-like domain; other site
1097668006694	active site
1097668006695	primary dimer interface [polypeptide binding]; other site
1097668006696	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097668006697	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097668006698	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097668006699	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097668006700	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097668006701	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097668006702	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668006703	ligand binding site [chemical binding]; other site
1097668006704	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1097668006705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668006706	S-adenosylmethionine binding site [chemical binding]; other site
1097668006707	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1097668006708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668006709	motif II; other site
1097668006710	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
1097668006711	PBP superfamily domain; Region: PBP_like; pfam12727
1097668006712	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
1097668006713	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
1097668006714	putative dimer interface [polypeptide binding]; other site
1097668006715	[2Fe-2S] cluster binding site [ion binding]; other site
1097668006716	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
1097668006717	putative dimer interface [polypeptide binding]; other site
1097668006718	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1097668006719	SLBB domain; Region: SLBB; pfam10531
1097668006720	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1097668006721	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668006722	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1097668006723	catalytic loop [active]
1097668006724	iron binding site [ion binding]; other site
1097668006725	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
1097668006726	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1097668006727	[4Fe-4S] binding site [ion binding]; other site
1097668006728	molybdopterin cofactor binding site; other site
1097668006729	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1097668006730	molybdopterin cofactor binding site; other site
1097668006731	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
1097668006732	hypothetical protein; Provisional; Region: PRK06184
1097668006733	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668006734	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668006735	binding surface
1097668006736	TPR motif; other site
1097668006737	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1097668006738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668006739	binding surface
1097668006740	TPR motif; other site
1097668006741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668006742	binding surface
1097668006743	TPR motif; other site
1097668006744	TPR repeat; Region: TPR_11; pfam13414
1097668006745	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668006746	binding surface
1097668006747	TPR motif; other site
1097668006748	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668006749	citrate-proton symporter; Provisional; Region: PRK15075
1097668006750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668006751	putative substrate translocation pore; other site
1097668006752	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097668006753	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668006754	Coenzyme A binding pocket [chemical binding]; other site
1097668006755	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1097668006756	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1097668006757	Peptidase C26; Region: Peptidase_C26; pfam07722
1097668006758	catalytic triad [active]
1097668006759	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1097668006760	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1097668006761	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1097668006762	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1097668006763	NAD synthetase; Provisional; Region: PRK13981
1097668006764	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1097668006765	multimer interface [polypeptide binding]; other site
1097668006766	active site
1097668006767	catalytic triad [active]
1097668006768	protein interface 1 [polypeptide binding]; other site
1097668006769	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1097668006770	homodimer interface [polypeptide binding]; other site
1097668006771	NAD binding pocket [chemical binding]; other site
1097668006772	ATP binding pocket [chemical binding]; other site
1097668006773	Mg binding site [ion binding]; other site
1097668006774	active-site loop [active]
1097668006775	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1097668006776	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1097668006777	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1097668006778	GIY-YIG motif/motif A; other site
1097668006779	putative active site [active]
1097668006780	putative metal binding site [ion binding]; other site
1097668006781	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1097668006782	dimer interface [polypeptide binding]; other site
1097668006783	substrate binding site [chemical binding]; other site
1097668006784	metal binding sites [ion binding]; metal-binding site
1097668006785	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668006786	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1097668006787	NAD(P) binding site [chemical binding]; other site
1097668006788	catalytic residues [active]
1097668006789	catalytic residues [active]
1097668006790	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
1097668006791	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1097668006792	putative NAD(P) binding site [chemical binding]; other site
1097668006793	active site
1097668006794	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668006795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668006796	putative substrate translocation pore; other site
1097668006797	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668006798	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1097668006799	putative ligand binding site [chemical binding]; other site
1097668006800	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668006801	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668006802	TM-ABC transporter signature motif; other site
1097668006803	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668006804	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668006805	TM-ABC transporter signature motif; other site
1097668006806	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1097668006807	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668006808	Walker A/P-loop; other site
1097668006809	ATP binding site [chemical binding]; other site
1097668006810	Q-loop/lid; other site
1097668006811	ABC transporter signature motif; other site
1097668006812	Walker B; other site
1097668006813	D-loop; other site
1097668006814	H-loop/switch region; other site
1097668006815	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1097668006816	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668006817	Walker A/P-loop; other site
1097668006818	ATP binding site [chemical binding]; other site
1097668006819	Q-loop/lid; other site
1097668006820	ABC transporter signature motif; other site
1097668006821	Walker B; other site
1097668006822	D-loop; other site
1097668006823	H-loop/switch region; other site
1097668006824	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1097668006825	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1097668006826	alpha-gamma subunit interface [polypeptide binding]; other site
1097668006827	beta-gamma subunit interface [polypeptide binding]; other site
1097668006828	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1097668006829	gamma-beta subunit interface [polypeptide binding]; other site
1097668006830	alpha-beta subunit interface [polypeptide binding]; other site
1097668006831	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1097668006832	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1097668006833	subunit interactions [polypeptide binding]; other site
1097668006834	active site
1097668006835	flap region; other site
1097668006836	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1097668006837	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1097668006838	dimer interface [polypeptide binding]; other site
1097668006839	catalytic residues [active]
1097668006840	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1097668006841	UreF; Region: UreF; pfam01730
1097668006842	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668006843	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
1097668006844	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1097668006845	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1097668006846	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668006847	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
1097668006848	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1097668006849	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
1097668006850	putative active site [active]
1097668006851	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1097668006852	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1097668006853	active site
1097668006854	substrate binding site [chemical binding]; other site
1097668006855	metal binding site [ion binding]; metal-binding site
1097668006856	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1097668006857	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1097668006858	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097668006859	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668006860	active site
1097668006861	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668006862	active site
1097668006863	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1097668006864	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668006865	putative ADP-binding pocket [chemical binding]; other site
1097668006866	UDP-glucose 4-epimerase; Region: PLN02240
1097668006867	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1097668006868	NAD binding site [chemical binding]; other site
1097668006869	homodimer interface [polypeptide binding]; other site
1097668006870	active site
1097668006871	substrate binding site [chemical binding]; other site
1097668006872	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
1097668006873	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1097668006874	Mg++ binding site [ion binding]; other site
1097668006875	putative catalytic motif [active]
1097668006876	Dienelactone hydrolase family; Region: DLH; pfam01738
1097668006877	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668006878	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668006879	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668006880	tyrosine kinase; Provisional; Region: PRK11519
1097668006881	Chain length determinant protein; Region: Wzz; pfam02706
1097668006882	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1097668006883	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668006884	polysaccharide export protein Wza; Provisional; Region: PRK15078
1097668006885	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1097668006886	SLBB domain; Region: SLBB; pfam10531
1097668006887	SLBB domain; Region: SLBB; pfam10531
1097668006888	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1097668006889	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1097668006890	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1097668006891	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1097668006892	Substrate binding site; other site
1097668006893	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1097668006894	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668006895	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097668006896	conserved cys residue [active]
1097668006897	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668006898	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668006899	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
1097668006900	active site
1097668006901	GDP-Mannose binding site [chemical binding]; other site
1097668006902	dimer interface [polypeptide binding]; other site
1097668006903	modified nudix motif
1097668006904	metal binding site [ion binding]; metal-binding site
1097668006905	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668006906	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097668006907	conserved cys residue [active]
1097668006908	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668006909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668006910	transcriptional regulator; Provisional; Region: PRK10632
1097668006911	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668006912	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1097668006913	putative effector binding pocket; other site
1097668006914	putative dimerization interface [polypeptide binding]; other site
1097668006915	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668006916	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1097668006917	CoA binding domain; Region: CoA_binding; smart00881
1097668006918	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668006919	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1097668006920	NAD(P) binding site [chemical binding]; other site
1097668006921	homodimer interface [polypeptide binding]; other site
1097668006922	substrate binding site [chemical binding]; other site
1097668006923	active site
1097668006924	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
1097668006925	Mg++ binding site [ion binding]; other site
1097668006926	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1097668006927	putative catalytic motif [active]
1097668006928	putative substrate binding site [chemical binding]; other site
1097668006929	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668006930	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
1097668006931	putative NAD(P) binding site [chemical binding]; other site
1097668006932	active site
1097668006933	putative substrate binding site [chemical binding]; other site
1097668006934	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097668006935	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668006936	active site
1097668006937	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668006938	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
1097668006939	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668006940	active site
1097668006941	catalytic residues [active]
1097668006942	Int/Topo IB signature motif; other site
1097668006943	DNA binding site [nucleotide binding]
1097668006944	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1097668006945	DNA-binding interface [nucleotide binding]; DNA binding site
1097668006946	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1097668006947	putative active site [active]
1097668006948	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
1097668006949	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097668006950	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668006951	active site
1097668006952	FAD dependent oxidoreductase; Region: DAO; pfam01266
1097668006953	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668006954	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1097668006955	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668006956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668006957	NAD(P) binding site [chemical binding]; other site
1097668006958	active site
1097668006959	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1097668006960	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1097668006961	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097668006962	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1097668006963	Ligand binding site; other site
1097668006964	Putative Catalytic site; other site
1097668006965	DXD motif; other site
1097668006966	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097668006967	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668006968	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
1097668006969	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668006970	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668006971	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1097668006972	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1097668006973	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1097668006974	Walker A/P-loop; other site
1097668006975	ATP binding site [chemical binding]; other site
1097668006976	Q-loop/lid; other site
1097668006977	ABC transporter signature motif; other site
1097668006978	Walker B; other site
1097668006979	D-loop; other site
1097668006980	H-loop/switch region; other site
1097668006981	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1097668006982	putative carbohydrate binding site [chemical binding]; other site
1097668006983	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1097668006984	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1097668006985	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668006986	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668006987	NAD(P) binding site [chemical binding]; other site
1097668006988	active site
1097668006989	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668006990	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
1097668006991	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
1097668006992	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1097668006993	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
1097668006994	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097668006995	Probable Catalytic site; other site
1097668006996	metal-binding site
1097668006997	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
1097668006998	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1097668006999	Probable Catalytic site; other site
1097668007000	metal-binding site
1097668007001	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
1097668007002	Ligand binding site; other site
1097668007003	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
1097668007004	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1097668007005	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1097668007006	NADP binding site [chemical binding]; other site
1097668007007	active site
1097668007008	putative substrate binding site [chemical binding]; other site
1097668007009	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
1097668007010	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1097668007011	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1097668007012	substrate binding site; other site
1097668007013	tetramer interface; other site
1097668007014	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1097668007015	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1097668007016	NAD binding site [chemical binding]; other site
1097668007017	substrate binding site [chemical binding]; other site
1097668007018	homodimer interface [polypeptide binding]; other site
1097668007019	active site
1097668007020	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1097668007021	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1097668007022	active site
1097668007023	metal binding site [ion binding]; metal-binding site
1097668007024	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1097668007025	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097668007026	putative acyl-acceptor binding pocket; other site
1097668007027	dihydroorotase; Provisional; Region: PRK07627
1097668007028	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668007029	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1097668007030	active site
1097668007031	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1097668007032	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1097668007033	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1097668007034	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1097668007035	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668007036	active site
1097668007037	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1097668007038	hypothetical protein; Validated; Region: PRK00228
1097668007039	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1097668007040	DNA photolyase; Region: DNA_photolyase; pfam00875
1097668007041	Rubredoxin [Energy production and conversion]; Region: COG1773
1097668007042	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1097668007043	iron binding site [ion binding]; other site
1097668007044	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1097668007045	dimer interface [polypeptide binding]; other site
1097668007046	substrate binding site [chemical binding]; other site
1097668007047	ATP binding site [chemical binding]; other site
1097668007048	Protein of unknown function DUF72; Region: DUF72; pfam01904
1097668007049	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1097668007050	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1097668007051	ring oligomerisation interface [polypeptide binding]; other site
1097668007052	ATP/Mg binding site [chemical binding]; other site
1097668007053	stacking interactions; other site
1097668007054	hinge regions; other site
1097668007055	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1097668007056	oligomerisation interface [polypeptide binding]; other site
1097668007057	mobile loop; other site
1097668007058	roof hairpin; other site
1097668007059	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668007060	Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001
1097668007061	3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605
1097668007062	BON domain; Region: BON; pfam04972
1097668007063	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1097668007064	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1097668007065	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
1097668007066	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1097668007067	putative catalytic residue [active]
1097668007068	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668007069	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668007070	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668007071	dimerization interface [polypeptide binding]; other site
1097668007072	Cupin; Region: Cupin_6; pfam12852
1097668007073	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668007074	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668007075	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1097668007076	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1097668007077	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668007078	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668007079	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1097668007080	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
1097668007081	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668007082	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1097668007083	major facilitator superfamily transporter; Provisional; Region: PRK05122
1097668007084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007085	putative substrate translocation pore; other site
1097668007086	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097668007087	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668007088	DNA-binding site [nucleotide binding]; DNA binding site
1097668007089	UTRA domain; Region: UTRA; pfam07702
1097668007090	putative transporter; Provisional; Region: PRK10504
1097668007091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007092	putative substrate translocation pore; other site
1097668007093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007094	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668007095	superoxide dismutase; Provisional; Region: PRK10543
1097668007096	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1097668007097	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1097668007098	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1097668007099	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1097668007100	generic binding surface II; other site
1097668007101	generic binding surface I; other site
1097668007102	tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906
1097668007103	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1097668007104	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1097668007105	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1097668007106	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1097668007107	Ligand binding site; other site
1097668007108	oligomer interface; other site
1097668007109	adenylate kinase; Reviewed; Region: adk; PRK00279
1097668007110	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1097668007111	AMP-binding site [chemical binding]; other site
1097668007112	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1097668007113	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1097668007114	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1097668007115	NAD binding site [chemical binding]; other site
1097668007116	homodimer interface [polypeptide binding]; other site
1097668007117	homotetramer interface [polypeptide binding]; other site
1097668007118	active site
1097668007119	Uncharacterized conserved protein [Function unknown]; Region: COG2912
1097668007120	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1097668007121	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1097668007122	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1097668007123	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1097668007124	Putative phage integrase; Region: Phage_Integr_2; pfam13009
1097668007125	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668007126	DNA binding site [nucleotide binding]
1097668007127	active site
1097668007128	Int/Topo IB signature motif; other site
1097668007129	catalytic residues [active]
1097668007130	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668007131	DNA binding site [nucleotide binding]
1097668007132	active site
1097668007133	Int/Topo IB signature motif; other site
1097668007134	catalytic residues [active]
1097668007135	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
1097668007136	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1097668007137	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1097668007138	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1097668007139	argininosuccinate synthase; Provisional; Region: PRK13820
1097668007140	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1097668007141	ANP binding site [chemical binding]; other site
1097668007142	Substrate Binding Site II [chemical binding]; other site
1097668007143	Substrate Binding Site I [chemical binding]; other site
1097668007144	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1097668007145	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668007146	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1097668007147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1097668007148	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1097668007149	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1097668007150	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1097668007151	putative deacylase active site [active]
1097668007152	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1097668007153	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1097668007154	active site
1097668007155	Int/Topo IB signature motif; other site
1097668007156	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1097668007157	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1097668007158	DNA binding site [nucleotide binding]
1097668007159	active site
1097668007160	epoxyqueuosine reductase; Region: TIGR00276
1097668007161	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1097668007162	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1097668007163	AMIN domain; Region: AMIN; pfam11741
1097668007164	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1097668007165	active site
1097668007166	metal binding site [ion binding]; metal-binding site
1097668007167	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1097668007168	Pirin-related protein [General function prediction only]; Region: COG1741
1097668007169	Pirin; Region: Pirin; pfam02678
1097668007170	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1097668007171	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1097668007172	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1097668007173	catalytic residues [active]
1097668007174	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1097668007175	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1097668007176	putative ATP binding site [chemical binding]; other site
1097668007177	putative substrate interface [chemical binding]; other site
1097668007178	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1097668007179	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1097668007180	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1097668007181	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1097668007182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668007183	S-adenosylmethionine binding site [chemical binding]; other site
1097668007184	Protein of unknown function DUF72; Region: DUF72; pfam01904
1097668007185	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1097668007186	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1097668007187	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668007188	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668007189	putative DNA binding site [nucleotide binding]; other site
1097668007190	putative Zn2+ binding site [ion binding]; other site
1097668007191	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668007192	arylformamidase; Region: trp_arylform; TIGR03035
1097668007193	kynureninase; Region: kynureninase; TIGR01814
1097668007194	Kynureninase [Amino acid transport and metabolism]; Region: COG3844
1097668007195	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668007196	catalytic residue [active]
1097668007197	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
1097668007198	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668007199	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668007200	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668007201	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1097668007202	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668007203	FAD binding site [chemical binding]; other site
1097668007204	substrate binding pocket [chemical binding]; other site
1097668007205	catalytic base [active]
1097668007206	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1097668007207	Predicted membrane protein [Function unknown]; Region: COG5393
1097668007208	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
1097668007209	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1097668007210	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1097668007211	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
1097668007212	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
1097668007213	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1097668007214	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1097668007215	ATP cone domain; Region: ATP-cone; pfam03477
1097668007216	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1097668007217	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1097668007218	dimer interface [polypeptide binding]; other site
1097668007219	active site
1097668007220	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1097668007221	folate binding site [chemical binding]; other site
1097668007222	malonic semialdehyde reductase; Provisional; Region: PRK10538
1097668007223	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1097668007224	putative NAD(P) binding site [chemical binding]; other site
1097668007225	homodimer interface [polypeptide binding]; other site
1097668007226	homotetramer interface [polypeptide binding]; other site
1097668007227	active site
1097668007228	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097668007229	active site
1097668007230	TolQ protein; Region: tolQ; TIGR02796
1097668007231	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1097668007232	TolR protein; Region: tolR; TIGR02801
1097668007233	TolA protein; Region: tolA_full; TIGR02794
1097668007234	TonB C terminal; Region: TonB_2; pfam13103
1097668007235	translocation protein TolB; Provisional; Region: tolB; PRK02889
1097668007236	TolB amino-terminal domain; Region: TolB_N; pfam04052
1097668007237	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1097668007238	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1097668007239	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1097668007240	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1097668007241	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668007242	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668007243	ligand binding site [chemical binding]; other site
1097668007244	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1097668007245	WYL domain; Region: WYL; pfam13280
1097668007246	AAA domain; Region: AAA_23; pfam13476
1097668007247	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1097668007248	AAA domain; Region: AAA_27; pfam13514
1097668007249	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1097668007250	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097668007251	active site
1097668007252	metal binding site [ion binding]; metal-binding site
1097668007253	DNA binding site [nucleotide binding]
1097668007254	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1097668007255	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1097668007256	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909
1097668007257	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1097668007258	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1097668007259	SurA N-terminal domain; Region: SurA_N; pfam09312
1097668007260	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1097668007261	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1097668007262	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1097668007263	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1097668007264	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1097668007265	Phosphotransferase enzyme family; Region: APH; pfam01636
1097668007266	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1097668007267	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1097668007268	Substrate binding site; other site
1097668007269	metal-binding site
1097668007270	adenylosuccinate lyase; Provisional; Region: PRK09285
1097668007271	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1097668007272	tetramer interface [polypeptide binding]; other site
1097668007273	active site
1097668007274	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
1097668007275	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668007276	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1097668007277	ATP-binding site [chemical binding]; other site
1097668007278	Gluconate-6-phosphate binding site [chemical binding]; other site
1097668007279	Shikimate kinase; Region: SKI; pfam01202
1097668007280	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1097668007281	GntP family permease; Region: GntP_permease; pfam02447
1097668007282	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1097668007283	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1097668007284	active site
1097668007285	intersubunit interface [polypeptide binding]; other site
1097668007286	catalytic residue [active]
1097668007287	phosphogluconate dehydratase; Validated; Region: PRK09054
1097668007288	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1097668007289	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097668007290	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097668007291	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097668007292	putative active site [active]
1097668007293	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
1097668007294	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1097668007295	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1097668007296	putative catalytic cysteine [active]
1097668007297	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1097668007298	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1097668007299	Lipopolysaccharide-assembly; Region: LptE; cl01125
1097668007300	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1097668007301	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1097668007302	HIGH motif; other site
1097668007303	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1097668007304	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1097668007305	active site
1097668007306	KMSKS motif; other site
1097668007307	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1097668007308	tRNA binding surface [nucleotide binding]; other site
1097668007309	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1097668007310	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1097668007311	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1097668007312	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1097668007313	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1097668007314	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1097668007315	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1097668007316	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1097668007317	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1097668007318	ferric uptake regulator; Provisional; Region: fur; PRK09462
1097668007319	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1097668007320	metal binding site 2 [ion binding]; metal-binding site
1097668007321	putative DNA binding helix; other site
1097668007322	metal binding site 1 [ion binding]; metal-binding site
1097668007323	dimer interface [polypeptide binding]; other site
1097668007324	structural Zn2+ binding site [ion binding]; other site
1097668007325	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1097668007326	ureidoglycolate hydrolase; Provisional; Region: PRK03606
1097668007327	allantoicase; Provisional; Region: PRK13257
1097668007328	Allantoicase repeat; Region: Allantoicase; pfam03561
1097668007329	Allantoicase repeat; Region: Allantoicase; pfam03561
1097668007330	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027
1097668007331	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097668007332	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668007333	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668007334	DNA-binding site [nucleotide binding]; DNA binding site
1097668007335	FCD domain; Region: FCD; pfam07729
1097668007336	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1097668007337	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1097668007338	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1097668007339	transketolase; Reviewed; Region: PRK12753
1097668007340	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1097668007341	TPP-binding site [chemical binding]; other site
1097668007342	dimer interface [polypeptide binding]; other site
1097668007343	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097668007344	PYR/PP interface [polypeptide binding]; other site
1097668007345	dimer interface [polypeptide binding]; other site
1097668007346	TPP binding site [chemical binding]; other site
1097668007347	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668007348	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1097668007349	putative dimer interface [polypeptide binding]; other site
1097668007350	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668007351	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1097668007352	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
1097668007353	putative RNAase interaction site [polypeptide binding]; other site
1097668007354	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
1097668007355	active site
1097668007356	barstar interaction site; other site
1097668007357	malic enzyme; Reviewed; Region: PRK12862
1097668007358	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1097668007359	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1097668007360	putative NAD(P) binding site [chemical binding]; other site
1097668007361	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1097668007362	thiamine monophosphate kinase; Provisional; Region: PRK05731
1097668007363	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1097668007364	ATP binding site [chemical binding]; other site
1097668007365	dimerization interface [polypeptide binding]; other site
1097668007366	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1097668007367	tetramer interfaces [polypeptide binding]; other site
1097668007368	binuclear metal-binding site [ion binding]; other site
1097668007369	Competence-damaged protein; Region: CinA; pfam02464
1097668007370	SWIM zinc finger; Region: SWIM; pfam04434
1097668007371	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1097668007372	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668007373	ATP binding site [chemical binding]; other site
1097668007374	putative Mg++ binding site [ion binding]; other site
1097668007375	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668007376	nucleotide binding region [chemical binding]; other site
1097668007377	ATP-binding site [chemical binding]; other site
1097668007378	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1097668007379	active site
1097668007380	dimer interface [polypeptide binding]; other site
1097668007381	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
1097668007382	active site
1097668007383	catalytic residues [active]
1097668007384	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097668007385	short chain dehydrogenase; Provisional; Region: PRK12939
1097668007386	classical (c) SDRs; Region: SDR_c; cd05233
1097668007387	NAD(P) binding site [chemical binding]; other site
1097668007388	active site
1097668007389	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668007390	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668007391	TM-ABC transporter signature motif; other site
1097668007392	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1097668007393	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668007394	Walker A/P-loop; other site
1097668007395	ATP binding site [chemical binding]; other site
1097668007396	Q-loop/lid; other site
1097668007397	ABC transporter signature motif; other site
1097668007398	Walker B; other site
1097668007399	D-loop; other site
1097668007400	H-loop/switch region; other site
1097668007401	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668007402	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1097668007403	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1097668007404	ligand binding site [chemical binding]; other site
1097668007405	short chain dehydrogenase; Provisional; Region: PRK07063
1097668007406	classical (c) SDRs; Region: SDR_c; cd05233
1097668007407	NAD(P) binding site [chemical binding]; other site
1097668007408	active site
1097668007409	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1097668007410	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1097668007411	active site
1097668007412	intersubunit interface [polypeptide binding]; other site
1097668007413	catalytic residue [active]
1097668007414	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1097668007415	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1097668007416	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668007417	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668007418	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668007419	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1097668007420	Transglycosylase; Region: Transgly; cl17702
1097668007421	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1097668007422	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668007423	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668007424	shikimate binding site; other site
1097668007425	NAD(P) binding site [chemical binding]; other site
1097668007426	Exoribonuclease R [Transcription]; Region: VacB; COG0557
1097668007427	RNB domain; Region: RNB; pfam00773
1097668007428	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1097668007429	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668007430	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1097668007431	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1097668007432	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097668007433	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097668007434	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1097668007435	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668007436	catalytic residues [active]
1097668007437	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1097668007438	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1097668007439	carboxyltransferase (CT) interaction site; other site
1097668007440	biotinylation site [posttranslational modification]; other site
1097668007441	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1097668007442	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097668007443	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668007444	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1097668007445	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1097668007446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668007447	S-adenosylmethionine binding site [chemical binding]; other site
1097668007448	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
1097668007449	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1097668007450	dimer interface [polypeptide binding]; other site
1097668007451	catalytic triad [active]
1097668007452	peroxidatic and resolving cysteines [active]
1097668007453	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1097668007454	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097668007455	substrate binding site [chemical binding]; other site
1097668007456	ATP binding site [chemical binding]; other site
1097668007457	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1097668007458	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1097668007459	dimer interface [polypeptide binding]; other site
1097668007460	putative radical transfer pathway; other site
1097668007461	diiron center [ion binding]; other site
1097668007462	tyrosyl radical; other site
1097668007463	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1097668007464	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007465	putative substrate translocation pore; other site
1097668007466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007467	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
1097668007468	ATP cone domain; Region: ATP-cone; pfam03477
1097668007469	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1097668007470	active site
1097668007471	dimer interface [polypeptide binding]; other site
1097668007472	catalytic residues [active]
1097668007473	effector binding site; other site
1097668007474	R2 peptide binding site; other site
1097668007475	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1097668007476	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1097668007477	amidase catalytic site [active]
1097668007478	Zn binding residues [ion binding]; other site
1097668007479	substrate binding site [chemical binding]; other site
1097668007480	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1097668007481	signal recognition particle protein; Provisional; Region: PRK10867
1097668007482	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1097668007483	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1097668007484	GTP binding site [chemical binding]; other site
1097668007485	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1097668007486	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668007487	active site
1097668007488	MarC family integral membrane protein; Region: MarC; cl00919
1097668007489	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1097668007490	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1097668007491	dimer interface [polypeptide binding]; other site
1097668007492	motif 1; other site
1097668007493	active site
1097668007494	motif 2; other site
1097668007495	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1097668007496	putative deacylase active site [active]
1097668007497	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1097668007498	active site
1097668007499	motif 3; other site
1097668007500	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1097668007501	anticodon binding site; other site
1097668007502	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1097668007503	putative active site [active]
1097668007504	Ap4A binding site [chemical binding]; other site
1097668007505	nudix motif; other site
1097668007506	putative metal binding site [ion binding]; other site
1097668007507	CNP1-like family; Region: CNP1; pfam08750
1097668007508	gamma-glutamyl kinase; Provisional; Region: PRK05429
1097668007509	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1097668007510	nucleotide binding site [chemical binding]; other site
1097668007511	homotetrameric interface [polypeptide binding]; other site
1097668007512	putative phosphate binding site [ion binding]; other site
1097668007513	putative allosteric binding site; other site
1097668007514	PUA domain; Region: PUA; pfam01472
1097668007515	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1097668007516	GTP1/OBG; Region: GTP1_OBG; pfam01018
1097668007517	Obg GTPase; Region: Obg; cd01898
1097668007518	G1 box; other site
1097668007519	GTP/Mg2+ binding site [chemical binding]; other site
1097668007520	Switch I region; other site
1097668007521	G2 box; other site
1097668007522	G3 box; other site
1097668007523	Switch II region; other site
1097668007524	G4 box; other site
1097668007525	G5 box; other site
1097668007526	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1097668007527	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1097668007528	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1097668007529	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1097668007530	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1097668007531	substrate binding pocket [chemical binding]; other site
1097668007532	chain length determination region; other site
1097668007533	substrate-Mg2+ binding site; other site
1097668007534	catalytic residues [active]
1097668007535	aspartate-rich region 1; other site
1097668007536	active site lid residues [active]
1097668007537	aspartate-rich region 2; other site
1097668007538	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1097668007539	Domain of unknown function DUF21; Region: DUF21; pfam01595
1097668007540	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1097668007541	Transporter associated domain; Region: CorC_HlyC; smart01091
1097668007542	Type II/IV secretion system protein; Region: T2SE; pfam00437
1097668007543	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668007544	Walker A motif; other site
1097668007545	ATP binding site [chemical binding]; other site
1097668007546	Walker B motif; other site
1097668007547	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1097668007548	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668007549	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668007550	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1097668007551	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1097668007552	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1097668007553	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1097668007554	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1097668007555	CoA-binding site [chemical binding]; other site
1097668007556	ATP-binding [chemical binding]; other site
1097668007557	hypothetical protein; Provisional; Region: PRK05287
1097668007558	Domain of unknown function (DUF329); Region: DUF329; pfam03884
1097668007559	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1097668007560	active site
1097668007561	8-oxo-dGMP binding site [chemical binding]; other site
1097668007562	nudix motif; other site
1097668007563	metal binding site [ion binding]; metal-binding site
1097668007564	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1097668007565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668007566	Walker A motif; other site
1097668007567	ATP binding site [chemical binding]; other site
1097668007568	Walker B motif; other site
1097668007569	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1097668007570	heterotetramer interface [polypeptide binding]; other site
1097668007571	active site pocket [active]
1097668007572	cleavage site
1097668007573	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1097668007574	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1097668007575	SEC-C motif; Region: SEC-C; pfam02810
1097668007576	Protein of unknown function (DUF721); Region: DUF721; cl02324
1097668007577	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
1097668007578	ligand binding site; other site
1097668007579	hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804
1097668007580	putative active site [active]
1097668007581	YdjC motif; other site
1097668007582	Mg binding site [ion binding]; other site
1097668007583	putative homodimer interface [polypeptide binding]; other site
1097668007584	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1097668007585	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1097668007586	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1097668007587	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1097668007588	catalytic triad [active]
1097668007589	dimer interface [polypeptide binding]; other site
1097668007590	cell division protein FtsZ; Validated; Region: PRK09330
1097668007591	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1097668007592	nucleotide binding site [chemical binding]; other site
1097668007593	SulA interaction site; other site
1097668007594	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
1097668007595	cell division protein FtsA; Region: ftsA; TIGR01174
1097668007596	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1097668007597	nucleotide binding site [chemical binding]; other site
1097668007598	Cell division protein FtsA; Region: FtsA; pfam14450
1097668007599	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1097668007600	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1097668007601	Cell division protein FtsQ; Region: FtsQ; pfam03799
1097668007602	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1097668007603	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1097668007604	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668007605	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1097668007606	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1097668007607	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097668007608	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097668007609	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1097668007610	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1097668007611	active site
1097668007612	homodimer interface [polypeptide binding]; other site
1097668007613	cell division protein FtsW; Region: ftsW; TIGR02614
1097668007614	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006
1097668007615	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097668007616	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097668007617	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1097668007618	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1097668007619	Mg++ binding site [ion binding]; other site
1097668007620	putative catalytic motif [active]
1097668007621	putative substrate binding site [chemical binding]; other site
1097668007622	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1097668007623	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1097668007624	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097668007625	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097668007626	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1097668007627	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097668007628	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097668007629	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1097668007630	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1097668007631	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1097668007632	Cell division protein FtsL; Region: FtsL; cl11433
1097668007633	MraW methylase family; Region: Methyltransf_5; cl17771
1097668007634	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1097668007635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1097668007636	MraZ protein; Region: MraZ; pfam02381
1097668007637	MraZ protein; Region: MraZ; pfam02381
1097668007638	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
1097668007639	diiron binding motif [ion binding]; other site
1097668007640	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668007641	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668007642	trimer interface [polypeptide binding]; other site
1097668007643	eyelet of channel; other site
1097668007644	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
1097668007645	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1097668007646	acyl-activating enzyme (AAE) consensus motif; other site
1097668007647	putative AMP binding site [chemical binding]; other site
1097668007648	putative active site [active]
1097668007649	putative CoA binding site [chemical binding]; other site
1097668007650	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1097668007651	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1097668007652	putative [4Fe-4S] binding site [ion binding]; other site
1097668007653	putative molybdopterin cofactor binding site [chemical binding]; other site
1097668007654	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
1097668007655	putative molybdopterin cofactor binding site; other site
1097668007656	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1097668007657	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1097668007658	metal binding site [ion binding]; metal-binding site
1097668007659	putative dimer interface [polypeptide binding]; other site
1097668007660	enoyl-CoA hydratase; Provisional; Region: PRK05862
1097668007661	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668007662	substrate binding site [chemical binding]; other site
1097668007663	oxyanion hole (OAH) forming residues; other site
1097668007664	trimer interface [polypeptide binding]; other site
1097668007665	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
1097668007666	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668007667	NAD(P) binding site [chemical binding]; other site
1097668007668	catalytic residues [active]
1097668007669	enoyl-CoA hydratase; Provisional; Region: PRK08140
1097668007670	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668007671	substrate binding site [chemical binding]; other site
1097668007672	oxyanion hole (OAH) forming residues; other site
1097668007673	trimer interface [polypeptide binding]; other site
1097668007674	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097668007675	CoenzymeA binding site [chemical binding]; other site
1097668007676	subunit interaction site [polypeptide binding]; other site
1097668007677	PHB binding site; other site
1097668007678	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
1097668007679	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1097668007680	active site
1097668007681	AMP binding site [chemical binding]; other site
1097668007682	homodimer interface [polypeptide binding]; other site
1097668007683	acyl-activating enzyme (AAE) consensus motif; other site
1097668007684	CoA binding site [chemical binding]; other site
1097668007685	MltA specific insert domain; Region: MltA; smart00925
1097668007686	3D domain; Region: 3D; pfam06725
1097668007687	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1097668007688	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1097668007689	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1097668007690	substrate binding site [chemical binding]; other site
1097668007691	hexamer interface [polypeptide binding]; other site
1097668007692	metal binding site [ion binding]; metal-binding site
1097668007693	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1097668007694	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668007695	motif II; other site
1097668007696	anthranilate synthase component I; Provisional; Region: PRK13565
1097668007697	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1097668007698	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1097668007699	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1097668007700	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1097668007701	glutamine binding [chemical binding]; other site
1097668007702	catalytic triad [active]
1097668007703	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1097668007704	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1097668007705	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1097668007706	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1097668007707	active site
1097668007708	ribulose/triose binding site [chemical binding]; other site
1097668007709	phosphate binding site [ion binding]; other site
1097668007710	substrate (anthranilate) binding pocket [chemical binding]; other site
1097668007711	product (indole) binding pocket [chemical binding]; other site
1097668007712	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
1097668007713	putative active site [active]
1097668007714	putative metal binding residues [ion binding]; other site
1097668007715	signature motif; other site
1097668007716	putative triphosphate binding site [ion binding]; other site
1097668007717	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1097668007718	ligand binding site [chemical binding]; other site
1097668007719	active site
1097668007720	UGI interface [polypeptide binding]; other site
1097668007721	catalytic site [active]
1097668007722	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1097668007723	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668007724	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
1097668007725	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
1097668007726	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668007727	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1097668007728	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1097668007729	dimerization domain [polypeptide binding]; other site
1097668007730	dimer interface [polypeptide binding]; other site
1097668007731	catalytic residues [active]
1097668007732	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
1097668007733	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1097668007734	GTP-binding protein YchF; Reviewed; Region: PRK09601
1097668007735	YchF GTPase; Region: YchF; cd01900
1097668007736	G1 box; other site
1097668007737	GTP/Mg2+ binding site [chemical binding]; other site
1097668007738	Switch I region; other site
1097668007739	G2 box; other site
1097668007740	Switch II region; other site
1097668007741	G3 box; other site
1097668007742	G4 box; other site
1097668007743	G5 box; other site
1097668007744	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1097668007745	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
1097668007746	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1097668007747	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668007748	Walker A/P-loop; other site
1097668007749	ATP binding site [chemical binding]; other site
1097668007750	Q-loop/lid; other site
1097668007751	ABC transporter signature motif; other site
1097668007752	Walker B; other site
1097668007753	D-loop; other site
1097668007754	H-loop/switch region; other site
1097668007755	ABC transporter; Region: ABC_tran_2; pfam12848
1097668007756	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1097668007757	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1097668007758	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1097668007759	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
1097668007760	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1097668007761	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1097668007762	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1097668007763	active site
1097668007764	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668007765	active site
1097668007766	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1097668007767	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1097668007768	tRNA; other site
1097668007769	putative tRNA binding site [nucleotide binding]; other site
1097668007770	putative NADP binding site [chemical binding]; other site
1097668007771	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1097668007772	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1097668007773	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1097668007774	RF-1 domain; Region: RF-1; pfam00472
1097668007775	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1097668007776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668007777	S-adenosylmethionine binding site [chemical binding]; other site
1097668007778	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1097668007779	putative GSH binding site [chemical binding]; other site
1097668007780	catalytic residues [active]
1097668007781	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1097668007782	Flavoprotein; Region: Flavoprotein; pfam02441
1097668007783	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1097668007784	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1097668007785	putative active site [active]
1097668007786	metal binding site [ion binding]; metal-binding site
1097668007787	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1097668007788	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1097668007789	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1097668007790	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1097668007791	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668007792	DNA-binding site [nucleotide binding]; DNA binding site
1097668007793	RNA-binding motif; other site
1097668007794	putative chaperone; Provisional; Region: PRK11678
1097668007795	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1097668007796	nucleotide binding site [chemical binding]; other site
1097668007797	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1097668007798	SBD interface [polypeptide binding]; other site
1097668007799	benzoate transport; Region: 2A0115; TIGR00895
1097668007800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007801	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007802	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
1097668007803	putative FMN binding site [chemical binding]; other site
1097668007804	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007805	putative substrate translocation pore; other site
1097668007806	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668007807	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668007808	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668007809	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
1097668007810	Methyltransferase domain; Region: Methyltransf_32; pfam13679
1097668007811	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1097668007812	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668007813	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668007814	DNA-binding site [nucleotide binding]; DNA binding site
1097668007815	FCD domain; Region: FCD; pfam07729
1097668007816	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1097668007817	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1097668007818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668007819	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668007820	putative substrate translocation pore; other site
1097668007821	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1097668007822	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1097668007823	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1097668007824	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1097668007825	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668007826	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1097668007827	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1097668007828	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1097668007829	C-terminal domain interface [polypeptide binding]; other site
1097668007830	putative GSH binding site (G-site) [chemical binding]; other site
1097668007831	dimer interface [polypeptide binding]; other site
1097668007832	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1097668007833	dimer interface [polypeptide binding]; other site
1097668007834	N-terminal domain interface [polypeptide binding]; other site
1097668007835	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1097668007836	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1097668007837	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1097668007838	Qi binding site; other site
1097668007839	intrachain domain interface; other site
1097668007840	interchain domain interface [polypeptide binding]; other site
1097668007841	heme bH binding site [chemical binding]; other site
1097668007842	heme bL binding site [chemical binding]; other site
1097668007843	Qo binding site; other site
1097668007844	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1097668007845	interchain domain interface [polypeptide binding]; other site
1097668007846	intrachain domain interface; other site
1097668007847	Qi binding site; other site
1097668007848	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
1097668007849	Qo binding site; other site
1097668007850	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1097668007851	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1097668007852	[2Fe-2S] cluster binding site [ion binding]; other site
1097668007853	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1097668007854	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1097668007855	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097668007856	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668007857	protein binding site [polypeptide binding]; other site
1097668007858	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1097668007859	sec-independent translocase; Provisional; Region: tatB; PRK01919
1097668007860	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
1097668007861	Predicted membrane protein [Function unknown]; Region: COG3671
1097668007862	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1097668007863	metal binding site [ion binding]; metal-binding site
1097668007864	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1097668007865	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1097668007866	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1097668007867	substrate binding site [chemical binding]; other site
1097668007868	glutamase interaction surface [polypeptide binding]; other site
1097668007869	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1097668007870	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1097668007871	catalytic residues [active]
1097668007872	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1097668007873	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1097668007874	putative active site [active]
1097668007875	oxyanion strand; other site
1097668007876	catalytic triad [active]
1097668007877	MarC family integral membrane protein; Region: MarC; cl00919
1097668007878	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1097668007879	putative active site pocket [active]
1097668007880	4-fold oligomerization interface [polypeptide binding]; other site
1097668007881	metal binding residues [ion binding]; metal-binding site
1097668007882	3-fold/trimer interface [polypeptide binding]; other site
1097668007883	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
1097668007884	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668007885	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668007886	homodimer interface [polypeptide binding]; other site
1097668007887	catalytic residue [active]
1097668007888	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1097668007889	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1097668007890	NAD binding site [chemical binding]; other site
1097668007891	dimerization interface [polypeptide binding]; other site
1097668007892	product binding site; other site
1097668007893	substrate binding site [chemical binding]; other site
1097668007894	zinc binding site [ion binding]; other site
1097668007895	catalytic residues [active]
1097668007896	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1097668007897	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1097668007898	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1097668007899	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1097668007900	hinge; other site
1097668007901	active site
1097668007902	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1097668007903	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1097668007904	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1097668007905	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1097668007906	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1097668007907	Walker A/P-loop; other site
1097668007908	ATP binding site [chemical binding]; other site
1097668007909	Q-loop/lid; other site
1097668007910	ABC transporter signature motif; other site
1097668007911	Walker B; other site
1097668007912	D-loop; other site
1097668007913	H-loop/switch region; other site
1097668007914	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1097668007915	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1097668007916	VacJ like lipoprotein; Region: VacJ; cl01073
1097668007917	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1097668007918	mce related protein; Region: MCE; pfam02470
1097668007919	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1097668007920	Permease; Region: Permease; pfam02405
1097668007921	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1097668007922	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1097668007923	Walker A/P-loop; other site
1097668007924	ATP binding site [chemical binding]; other site
1097668007925	Q-loop/lid; other site
1097668007926	ABC transporter signature motif; other site
1097668007927	Walker B; other site
1097668007928	D-loop; other site
1097668007929	H-loop/switch region; other site
1097668007930	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1097668007931	thiamine phosphate binding site [chemical binding]; other site
1097668007932	active site
1097668007933	pyrophosphate binding site [ion binding]; other site
1097668007934	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1097668007935	ThiS interaction site; other site
1097668007936	putative active site [active]
1097668007937	tetramer interface [polypeptide binding]; other site
1097668007938	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1097668007939	thiS-thiF/thiG interaction site; other site
1097668007940	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1097668007941	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1097668007942	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1097668007943	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1097668007944	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1097668007945	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1097668007946	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1097668007947	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1097668007948	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668007949	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1097668007950	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1097668007951	active site
1097668007952	dimer interface [polypeptide binding]; other site
1097668007953	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1097668007954	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1097668007955	active site
1097668007956	FMN binding site [chemical binding]; other site
1097668007957	substrate binding site [chemical binding]; other site
1097668007958	3Fe-4S cluster binding site [ion binding]; other site
1097668007959	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1097668007960	domain interface; other site
1097668007961	Transposase IS200 like; Region: Y1_Tnp; cl00848
1097668007962	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1097668007963	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
1097668007964	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
1097668007965	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
1097668007966	putative active site [active]
1097668007967	catalytic site [active]
1097668007968	putative metal binding site [ion binding]; other site
1097668007969	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1097668007970	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1097668007971	Walker A/P-loop; other site
1097668007972	ATP binding site [chemical binding]; other site
1097668007973	Q-loop/lid; other site
1097668007974	ABC transporter signature motif; other site
1097668007975	Walker B; other site
1097668007976	D-loop; other site
1097668007977	H-loop/switch region; other site
1097668007978	TOBE domain; Region: TOBE_2; pfam08402
1097668007979	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097668007980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668007981	dimer interface [polypeptide binding]; other site
1097668007982	conserved gate region; other site
1097668007983	putative PBP binding loops; other site
1097668007984	ABC-ATPase subunit interface; other site
1097668007985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097668007986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668007987	dimer interface [polypeptide binding]; other site
1097668007988	conserved gate region; other site
1097668007989	putative PBP binding loops; other site
1097668007990	ABC-ATPase subunit interface; other site
1097668007991	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
1097668007992	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097668007993	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
1097668007994	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097668007995	Zn2+ binding site [ion binding]; other site
1097668007996	Mg2+ binding site [ion binding]; other site
1097668007997	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1097668007998	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1097668007999	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1097668008000	active site
1097668008001	dimer interface [polypeptide binding]; other site
1097668008002	metal binding site [ion binding]; metal-binding site
1097668008003	shikimate kinase; Reviewed; Region: aroK; PRK00131
1097668008004	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1097668008005	ADP binding site [chemical binding]; other site
1097668008006	magnesium binding site [ion binding]; other site
1097668008007	putative shikimate binding site; other site
1097668008008	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1097668008009	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1097668008010	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1097668008011	Pilus assembly protein, PilO; Region: PilO; cl01234
1097668008012	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1097668008013	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
1097668008014	Transglycosylase; Region: Transgly; pfam00912
1097668008015	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1097668008016	frataxin-like protein; Provisional; Region: cyaY; PRK00446
1097668008017	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1097668008018	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1097668008019	active site
1097668008020	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668008021	substrate binding site [chemical binding]; other site
1097668008022	catalytic residues [active]
1097668008023	dimer interface [polypeptide binding]; other site
1097668008024	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1097668008025	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1097668008026	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
1097668008027	Moco binding site; other site
1097668008028	metal coordination site [ion binding]; other site
1097668008029	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1097668008030	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1097668008031	ResB-like family; Region: ResB; pfam05140
1097668008032	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1097668008033	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
1097668008034	Cytochrome c; Region: Cytochrom_C; cl11414
1097668008035	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1097668008036	G1 box; other site
1097668008037	GTP/Mg2+ binding site [chemical binding]; other site
1097668008038	Switch I region; other site
1097668008039	G2 box; other site
1097668008040	G3 box; other site
1097668008041	Switch II region; other site
1097668008042	G4 box; other site
1097668008043	G5 box; other site
1097668008044	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1097668008045	dimer interface [polypeptide binding]; other site
1097668008046	active site
1097668008047	aspartate-rich active site metal binding site; other site
1097668008048	allosteric magnesium binding site [ion binding]; other site
1097668008049	Schiff base residues; other site
1097668008050	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1097668008051	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1097668008052	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1097668008053	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1097668008054	DsbD alpha interface [polypeptide binding]; other site
1097668008055	catalytic residues [active]
1097668008056	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
1097668008057	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1097668008058	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1097668008059	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1097668008060	alphaNTD homodimer interface [polypeptide binding]; other site
1097668008061	alphaNTD - beta interaction site [polypeptide binding]; other site
1097668008062	alphaNTD - beta' interaction site [polypeptide binding]; other site
1097668008063	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1097668008064	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1097668008065	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1097668008066	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1097668008067	RNA binding surface [nucleotide binding]; other site
1097668008068	30S ribosomal protein S11; Validated; Region: PRK05309
1097668008069	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1097668008070	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1097668008071	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
1097668008072	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1097668008073	rRNA binding site [nucleotide binding]; other site
1097668008074	predicted 30S ribosome binding site; other site
1097668008075	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1097668008076	SecY translocase; Region: SecY; pfam00344
1097668008077	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1097668008078	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1097668008079	23S rRNA binding site [nucleotide binding]; other site
1097668008080	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1097668008081	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1097668008082	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1097668008083	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1097668008084	5S rRNA interface [nucleotide binding]; other site
1097668008085	L27 interface [polypeptide binding]; other site
1097668008086	23S rRNA interface [nucleotide binding]; other site
1097668008087	L5 interface [polypeptide binding]; other site
1097668008088	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1097668008089	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1097668008090	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1097668008091	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1097668008092	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1097668008093	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1097668008094	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1097668008095	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1097668008096	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1097668008097	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1097668008098	RNA binding site [nucleotide binding]; other site
1097668008099	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1097668008100	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1097668008101	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1097668008102	23S rRNA interface [nucleotide binding]; other site
1097668008103	putative translocon interaction site; other site
1097668008104	signal recognition particle (SRP54) interaction site; other site
1097668008105	L23 interface [polypeptide binding]; other site
1097668008106	trigger factor interaction site; other site
1097668008107	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1097668008108	23S rRNA interface [nucleotide binding]; other site
1097668008109	5S rRNA interface [nucleotide binding]; other site
1097668008110	putative antibiotic binding site [chemical binding]; other site
1097668008111	L25 interface [polypeptide binding]; other site
1097668008112	L27 interface [polypeptide binding]; other site
1097668008113	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1097668008114	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1097668008115	G-X-X-G motif; other site
1097668008116	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1097668008117	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1097668008118	putative translocon binding site; other site
1097668008119	protein-rRNA interface [nucleotide binding]; other site
1097668008120	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1097668008121	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1097668008122	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1097668008123	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1097668008124	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1097668008125	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1097668008126	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1097668008127	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1097668008128	elongation factor Tu; Reviewed; Region: PRK00049
1097668008129	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1097668008130	G1 box; other site
1097668008131	GEF interaction site [polypeptide binding]; other site
1097668008132	GTP/Mg2+ binding site [chemical binding]; other site
1097668008133	Switch I region; other site
1097668008134	G2 box; other site
1097668008135	G3 box; other site
1097668008136	Switch II region; other site
1097668008137	G4 box; other site
1097668008138	G5 box; other site
1097668008139	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1097668008140	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1097668008141	Antibiotic Binding Site [chemical binding]; other site
1097668008142	elongation factor G; Reviewed; Region: PRK00007
1097668008143	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1097668008144	G1 box; other site
1097668008145	putative GEF interaction site [polypeptide binding]; other site
1097668008146	GTP/Mg2+ binding site [chemical binding]; other site
1097668008147	Switch I region; other site
1097668008148	G2 box; other site
1097668008149	G3 box; other site
1097668008150	Switch II region; other site
1097668008151	G4 box; other site
1097668008152	G5 box; other site
1097668008153	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1097668008154	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1097668008155	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1097668008156	30S ribosomal protein S7; Validated; Region: PRK05302
1097668008157	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1097668008158	S17 interaction site [polypeptide binding]; other site
1097668008159	S8 interaction site; other site
1097668008160	16S rRNA interaction site [nucleotide binding]; other site
1097668008161	streptomycin interaction site [chemical binding]; other site
1097668008162	23S rRNA interaction site [nucleotide binding]; other site
1097668008163	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1097668008164	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1097668008165	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668008166	ATP binding site [chemical binding]; other site
1097668008167	putative Mg++ binding site [ion binding]; other site
1097668008168	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668008169	nucleotide binding region [chemical binding]; other site
1097668008170	ATP-binding site [chemical binding]; other site
1097668008171	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1097668008172	HRDC domain; Region: HRDC; pfam00570
1097668008173	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1097668008174	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1097668008175	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1097668008176	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1097668008177	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1097668008178	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1097668008179	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1097668008180	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1097668008181	DNA binding site [nucleotide binding]
1097668008182	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1097668008183	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1097668008184	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1097668008185	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1097668008186	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1097668008187	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1097668008188	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1097668008189	RPB3 interaction site [polypeptide binding]; other site
1097668008190	RPB1 interaction site [polypeptide binding]; other site
1097668008191	RPB11 interaction site [polypeptide binding]; other site
1097668008192	RPB10 interaction site [polypeptide binding]; other site
1097668008193	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1097668008194	peripheral dimer interface [polypeptide binding]; other site
1097668008195	core dimer interface [polypeptide binding]; other site
1097668008196	L10 interface [polypeptide binding]; other site
1097668008197	L11 interface [polypeptide binding]; other site
1097668008198	putative EF-Tu interaction site [polypeptide binding]; other site
1097668008199	putative EF-G interaction site [polypeptide binding]; other site
1097668008200	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1097668008201	23S rRNA interface [nucleotide binding]; other site
1097668008202	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1097668008203	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1097668008204	mRNA/rRNA interface [nucleotide binding]; other site
1097668008205	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1097668008206	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1097668008207	23S rRNA interface [nucleotide binding]; other site
1097668008208	L7/L12 interface [polypeptide binding]; other site
1097668008209	putative thiostrepton binding site; other site
1097668008210	L25 interface [polypeptide binding]; other site
1097668008211	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1097668008212	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1097668008213	putative homodimer interface [polypeptide binding]; other site
1097668008214	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1097668008215	heterodimer interface [polypeptide binding]; other site
1097668008216	homodimer interface [polypeptide binding]; other site
1097668008217	elongation factor Tu; Reviewed; Region: PRK00049
1097668008218	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1097668008219	G1 box; other site
1097668008220	GEF interaction site [polypeptide binding]; other site
1097668008221	GTP/Mg2+ binding site [chemical binding]; other site
1097668008222	Switch I region; other site
1097668008223	G2 box; other site
1097668008224	G3 box; other site
1097668008225	Switch II region; other site
1097668008226	G4 box; other site
1097668008227	G5 box; other site
1097668008228	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1097668008229	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1097668008230	Antibiotic Binding Site [chemical binding]; other site
1097668008231	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
1097668008232	active site
1097668008233	catalytic triad [active]
1097668008234	oxyanion hole [active]
1097668008235	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1097668008236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668008237	S-adenosylmethionine binding site [chemical binding]; other site
1097668008238	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
1097668008239	benzoate transport; Region: 2A0115; TIGR00895
1097668008240	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008241	putative substrate translocation pore; other site
1097668008242	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1097668008243	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1097668008244	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1097668008245	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1097668008246	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1097668008247	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1097668008248	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1097668008249	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1097668008250	FAD binding pocket [chemical binding]; other site
1097668008251	FAD binding motif [chemical binding]; other site
1097668008252	phosphate binding motif [ion binding]; other site
1097668008253	beta-alpha-beta structure motif; other site
1097668008254	NAD(p) ribose binding residues [chemical binding]; other site
1097668008255	NAD binding pocket [chemical binding]; other site
1097668008256	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1097668008257	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668008258	catalytic loop [active]
1097668008259	iron binding site [ion binding]; other site
1097668008260	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1097668008261	Protein of unknown function; Region: DUF3658; pfam12395
1097668008262	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668008263	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668008264	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097668008265	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668008266	Coenzyme A binding pocket [chemical binding]; other site
1097668008267	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668008268	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668008269	putative DNA binding site [nucleotide binding]; other site
1097668008270	putative Zn2+ binding site [ion binding]; other site
1097668008271	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668008272	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1097668008273	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1097668008274	dimer interface [polypeptide binding]; other site
1097668008275	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1097668008276	active site
1097668008277	Fe binding site [ion binding]; other site
1097668008278	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
1097668008279	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1097668008280	dimer interface [polypeptide binding]; other site
1097668008281	PYR/PP interface [polypeptide binding]; other site
1097668008282	TPP binding site [chemical binding]; other site
1097668008283	substrate binding site [chemical binding]; other site
1097668008284	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
1097668008285	TPP-binding site; other site
1097668008286	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1097668008287	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1097668008288	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1097668008289	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1097668008290	putative NAD(P) binding site [chemical binding]; other site
1097668008291	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1097668008292	benzoate transport; Region: 2A0115; TIGR00895
1097668008293	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008294	putative substrate translocation pore; other site
1097668008295	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668008296	active site
1097668008297	transcriptional regulator RcsB; Provisional; Region: PRK10840
1097668008298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668008299	active site
1097668008300	phosphorylation site [posttranslational modification]
1097668008301	intermolecular recognition site; other site
1097668008302	dimerization interface [polypeptide binding]; other site
1097668008303	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668008304	DNA binding residues [nucleotide binding]
1097668008305	dimerization interface [polypeptide binding]; other site
1097668008306	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1097668008307	substrate binding site [chemical binding]; other site
1097668008308	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1097668008309	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668008310	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1097668008311	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1097668008312	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668008313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668008314	active site
1097668008315	phosphorylation site [posttranslational modification]
1097668008316	intermolecular recognition site; other site
1097668008317	dimerization interface [polypeptide binding]; other site
1097668008318	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668008319	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1097668008320	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668008321	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
1097668008322	Uncharacterized conserved protein [Function unknown]; Region: COG1656
1097668008323	Protein of unknown function DUF82; Region: DUF82; pfam01927
1097668008324	Cupin domain; Region: Cupin_2; cl17218
1097668008325	citrate-proton symporter; Provisional; Region: PRK15075
1097668008326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008327	putative substrate translocation pore; other site
1097668008328	High potential iron-sulfur protein; Region: HIPIP; pfam01355
1097668008329	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668008330	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668008331	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668008332	ATP binding site [chemical binding]; other site
1097668008333	Walker A motif; other site
1097668008334	Walker B motif; other site
1097668008335	arginine finger; other site
1097668008336	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1097668008337	putative catalytic site [active]
1097668008338	putative metal binding site [ion binding]; other site
1097668008339	putative phosphate binding site [ion binding]; other site
1097668008340	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668008341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668008342	active site
1097668008343	phosphorylation site [posttranslational modification]
1097668008344	intermolecular recognition site; other site
1097668008345	dimerization interface [polypeptide binding]; other site
1097668008346	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1097668008347	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1097668008348	homotrimer interaction site [polypeptide binding]; other site
1097668008349	putative active site [active]
1097668008350	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668008351	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668008352	metal binding site [ion binding]; metal-binding site
1097668008353	active site
1097668008354	I-site; other site
1097668008355	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1097668008356	ArsC family; Region: ArsC; pfam03960
1097668008357	catalytic residues [active]
1097668008358	Cupin domain; Region: Cupin_2; cl17218
1097668008359	Protein of unknown function DUF72; Region: DUF72; pfam01904
1097668008360	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1097668008361	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1097668008362	active site
1097668008363	tetramer interface [polypeptide binding]; other site
1097668008364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008365	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668008366	putative substrate translocation pore; other site
1097668008367	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008368	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668008369	putative substrate translocation pore; other site
1097668008370	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1097668008371	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1097668008372	putative ligand binding site [chemical binding]; other site
1097668008373	NAD binding site [chemical binding]; other site
1097668008374	catalytic site [active]
1097668008375	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1097668008376	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668008377	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
1097668008378	putative dimerization interface [polypeptide binding]; other site
1097668008379	putative substrate binding pocket [chemical binding]; other site
1097668008380	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668008381	tartronate semialdehyde reductase; Provisional; Region: PRK15059
1097668008382	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1097668008383	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668008384	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668008385	DNA-binding site [nucleotide binding]; DNA binding site
1097668008386	FCD domain; Region: FCD; pfam07729
1097668008387	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
1097668008388	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668008389	HipA N-terminal domain; Region: Couple_hipA; cl11853
1097668008390	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1097668008391	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1097668008392	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1097668008393	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1097668008394	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1097668008395	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1097668008396	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1097668008397	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668008398	dimerization interface [polypeptide binding]; other site
1097668008399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668008400	dimer interface [polypeptide binding]; other site
1097668008401	phosphorylation site [posttranslational modification]
1097668008402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668008403	ATP binding site [chemical binding]; other site
1097668008404	Mg2+ binding site [ion binding]; other site
1097668008405	G-X-G motif; other site
1097668008406	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1097668008407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668008408	active site
1097668008409	phosphorylation site [posttranslational modification]
1097668008410	intermolecular recognition site; other site
1097668008411	dimerization interface [polypeptide binding]; other site
1097668008412	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668008413	DNA binding site [nucleotide binding]
1097668008414	Outer membrane efflux protein; Region: OEP; pfam02321
1097668008415	Outer membrane efflux protein; Region: OEP; pfam02321
1097668008416	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1097668008417	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1097668008418	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1097668008419	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1097668008420	CopC domain; Region: CopC; pfam04234
1097668008421	Domain of unknown function (DUF305); Region: DUF305; cl17794
1097668008422	YHS domain; Region: YHS; pfam04945
1097668008423	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1097668008424	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097668008425	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668008426	motif II; other site
1097668008427	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1097668008428	Outer membrane efflux protein; Region: OEP; pfam02321
1097668008429	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1097668008430	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
1097668008431	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668008432	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1097668008433	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1097668008434	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1097668008435	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1097668008436	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1097668008437	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097668008438	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1097668008439	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1097668008440	arsenical-resistance protein; Region: acr3; TIGR00832
1097668008441	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1097668008442	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1097668008443	active site
1097668008444	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668008445	putative DNA binding site [nucleotide binding]; other site
1097668008446	putative Zn2+ binding site [ion binding]; other site
1097668008447	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1097668008448	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668008449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008450	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668008451	putative substrate translocation pore; other site
1097668008452	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668008453	putative transposase OrfB; Reviewed; Region: PHA02517
1097668008454	HTH-like domain; Region: HTH_21; pfam13276
1097668008455	Integrase core domain; Region: rve; pfam00665
1097668008456	Integrase core domain; Region: rve_3; pfam13683
1097668008457	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
1097668008458	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1097668008459	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1097668008460	glutaminase active site [active]
1097668008461	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1097668008462	dimer interface [polypeptide binding]; other site
1097668008463	active site
1097668008464	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1097668008465	dimer interface [polypeptide binding]; other site
1097668008466	active site
1097668008467	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
1097668008468	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1097668008469	Substrate binding site; other site
1097668008470	Mg++ binding site; other site
1097668008471	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1097668008472	active site
1097668008473	substrate binding site [chemical binding]; other site
1097668008474	CoA binding site [chemical binding]; other site
1097668008475	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1097668008476	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1097668008477	Ligand Binding Site [chemical binding]; other site
1097668008478	Dihydroneopterin aldolase; Region: FolB; smart00905
1097668008479	active site
1097668008480	short chain dehydrogenase; Provisional; Region: PRK09134
1097668008481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668008482	NAD(P) binding site [chemical binding]; other site
1097668008483	active site
1097668008484	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1097668008485	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1097668008486	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1097668008487	active site
1097668008488	NTP binding site [chemical binding]; other site
1097668008489	metal binding triad [ion binding]; metal-binding site
1097668008490	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1097668008491	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097668008492	Zn2+ binding site [ion binding]; other site
1097668008493	Mg2+ binding site [ion binding]; other site
1097668008494	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668008495	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
1097668008496	putative C-terminal domain interface [polypeptide binding]; other site
1097668008497	putative GSH binding site (G-site) [chemical binding]; other site
1097668008498	putative dimer interface [polypeptide binding]; other site
1097668008499	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1097668008500	putative substrate binding pocket (H-site) [chemical binding]; other site
1097668008501	putative N-terminal domain interface [polypeptide binding]; other site
1097668008502	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1097668008503	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1097668008504	putative NAD(P) binding site [chemical binding]; other site
1097668008505	active site
1097668008506	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1097668008507	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668008508	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668008509	catalytic residue [active]
1097668008510	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1097668008511	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
1097668008512	MarR family; Region: MarR_2; cl17246
1097668008513	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668008514	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1097668008515	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
1097668008516	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
1097668008517	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
1097668008518	putative active site [active]
1097668008519	Protein of unknown function (DUF969); Region: DUF969; pfam06149
1097668008520	Predicted membrane protein [Function unknown]; Region: COG3817
1097668008521	Protein of unknown function (DUF979); Region: DUF979; pfam06166
1097668008522	TraB family; Region: TraB; pfam01963
1097668008523	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1097668008524	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668008525	Walker A/P-loop; other site
1097668008526	ATP binding site [chemical binding]; other site
1097668008527	Q-loop/lid; other site
1097668008528	ABC transporter signature motif; other site
1097668008529	Walker B; other site
1097668008530	D-loop; other site
1097668008531	H-loop/switch region; other site
1097668008532	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1097668008533	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1097668008534	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668008535	Walker A/P-loop; other site
1097668008536	ATP binding site [chemical binding]; other site
1097668008537	Q-loop/lid; other site
1097668008538	ABC transporter signature motif; other site
1097668008539	Walker B; other site
1097668008540	D-loop; other site
1097668008541	H-loop/switch region; other site
1097668008542	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668008543	dipeptide transporter; Provisional; Region: PRK10913
1097668008544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668008545	dimer interface [polypeptide binding]; other site
1097668008546	ABC-ATPase subunit interface; other site
1097668008547	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097668008548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668008549	dimer interface [polypeptide binding]; other site
1097668008550	conserved gate region; other site
1097668008551	putative PBP binding loops; other site
1097668008552	ABC-ATPase subunit interface; other site
1097668008553	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668008554	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1097668008555	peptide binding site [polypeptide binding]; other site
1097668008556	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1097668008557	FAD binding site [chemical binding]; other site
1097668008558	Membrane protein of unknown function; Region: DUF360; pfam04020
1097668008559	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1097668008560	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1097668008561	homotetramer interface [polypeptide binding]; other site
1097668008562	ligand binding site [chemical binding]; other site
1097668008563	catalytic site [active]
1097668008564	NAD binding site [chemical binding]; other site
1097668008565	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1097668008566	LrgA family; Region: LrgA; pfam03788
1097668008567	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668008568	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668008569	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1097668008570	putative dimerization interface [polypeptide binding]; other site
1097668008571	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668008572	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668008573	ligand binding site [chemical binding]; other site
1097668008574	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1097668008575	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668008576	active site
1097668008577	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1097668008578	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1097668008579	Flagellar protein FliT; Region: FliT; cl05125
1097668008580	flagellar protein FliS; Validated; Region: fliS; PRK05685
1097668008581	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
1097668008582	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1097668008583	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
1097668008584	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1097668008585	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1097668008586	FliG C-terminal domain; Region: FliG_C; pfam01706
1097668008587	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1097668008588	Flagellar assembly protein FliH; Region: FliH; pfam02108
1097668008589	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
1097668008590	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1097668008591	Walker A motif/ATP binding site; other site
1097668008592	Walker B motif; other site
1097668008593	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
1097668008594	Flagellar FliJ protein; Region: FliJ; pfam02050
1097668008595	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1097668008596	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
1097668008597	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1097668008598	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1097668008599	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
1097668008600	flagellar motor switch protein; Validated; Region: fliN; PRK05698
1097668008601	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1097668008602	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1097668008603	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1097668008604	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1097668008605	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
1097668008606	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1097668008607	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945
1097668008608	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
1097668008609	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1097668008610	Flagellar regulator YcgR; Region: YcgR; pfam07317
1097668008611	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1097668008612	PilZ domain; Region: PilZ; pfam07238
1097668008613	flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709
1097668008614	Rod binding protein; Region: Rod-binding; cl01626
1097668008615	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1097668008616	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1097668008617	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1097668008618	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697
1097668008619	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
1097668008620	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
1097668008621	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1097668008622	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1097668008623	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
1097668008624	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1097668008625	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1097668008626	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1097668008627	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1097668008628	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1097668008629	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1097668008630	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1097668008631	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1097668008632	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1097668008633	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1097668008634	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1097668008635	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626
1097668008636	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1097668008637	SAF-like; Region: SAF_2; pfam13144
1097668008638	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1097668008639	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
1097668008640	FlgN protein; Region: FlgN; pfam05130
1097668008641	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1097668008642	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1097668008643	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1097668008644	FHIPEP family; Region: FHIPEP; pfam00771
1097668008645	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
1097668008646	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1097668008647	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1097668008648	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1097668008649	Alginate lyase; Region: Alginate_lyase; pfam05426
1097668008650	glycine dehydrogenase; Provisional; Region: PRK05367
1097668008651	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1097668008652	tetramer interface [polypeptide binding]; other site
1097668008653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668008654	catalytic residue [active]
1097668008655	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1097668008656	tetramer interface [polypeptide binding]; other site
1097668008657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668008658	catalytic residue [active]
1097668008659	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1097668008660	lipoyl attachment site [posttranslational modification]; other site
1097668008661	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1097668008662	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1097668008663	putative oxidoreductase; Provisional; Region: PRK11579
1097668008664	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668008665	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668008666	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
1097668008667	Part of AAA domain; Region: AAA_19; pfam13245
1097668008668	Family description; Region: UvrD_C_2; pfam13538
1097668008669	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
1097668008670	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
1097668008671	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668008672	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1097668008673	catalytic triad [active]
1097668008674	conserved cis-peptide bond; other site
1097668008675	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668008676	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668008677	[2Fe-2S] cluster binding site [ion binding]; other site
1097668008678	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668008679	hydrophobic ligand binding site; other site
1097668008680	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668008681	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668008682	metal binding site [ion binding]; metal-binding site
1097668008683	active site
1097668008684	I-site; other site
1097668008685	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1097668008686	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668008687	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097668008688	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668008689	DNA binding residues [nucleotide binding]
1097668008690	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1097668008691	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668008692	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
1097668008693	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668008694	thiamine pyrophosphate protein; Validated; Region: PRK08199
1097668008695	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668008696	PYR/PP interface [polypeptide binding]; other site
1097668008697	dimer interface [polypeptide binding]; other site
1097668008698	TPP binding site [chemical binding]; other site
1097668008699	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668008700	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1097668008701	TPP-binding site [chemical binding]; other site
1097668008702	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
1097668008703	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1097668008704	LabA_like proteins; Region: LabA_like; cd06167
1097668008705	putative metal binding site [ion binding]; other site
1097668008706	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1097668008707	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668008708	RNA-binding motif; other site
1097668008709	DNA-binding site [nucleotide binding]; DNA binding site
1097668008710	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668008711	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668008712	dimerization interface [polypeptide binding]; other site
1097668008713	ligand binding site [chemical binding]; other site
1097668008714	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
1097668008715	Predicted transcriptional regulator [Transcription]; Region: COG3905
1097668008716	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
1097668008717	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1097668008718	Glutamate binding site [chemical binding]; other site
1097668008719	NAD binding site [chemical binding]; other site
1097668008720	catalytic residues [active]
1097668008721	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668008722	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1097668008723	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668008724	ATP binding site [chemical binding]; other site
1097668008725	putative Mg++ binding site [ion binding]; other site
1097668008726	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1097668008727	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1097668008728	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1097668008729	substrate binding site [chemical binding]; other site
1097668008730	active site
1097668008731	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668008732	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668008733	substrate binding pocket [chemical binding]; other site
1097668008734	membrane-bound complex binding site; other site
1097668008735	hinge residues; other site
1097668008736	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1097668008737	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668008738	AMP-binding domain protein; Validated; Region: PRK08315
1097668008739	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668008740	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1097668008741	acyl-activating enzyme (AAE) consensus motif; other site
1097668008742	putative AMP binding site [chemical binding]; other site
1097668008743	putative active site [active]
1097668008744	putative CoA binding site [chemical binding]; other site
1097668008745	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1097668008746	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1097668008747	gamma subunit interface [polypeptide binding]; other site
1097668008748	epsilon subunit interface [polypeptide binding]; other site
1097668008749	LBP interface [polypeptide binding]; other site
1097668008750	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1097668008751	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1097668008752	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1097668008753	alpha subunit interaction interface [polypeptide binding]; other site
1097668008754	Walker A motif; other site
1097668008755	ATP binding site [chemical binding]; other site
1097668008756	Walker B motif; other site
1097668008757	inhibitor binding site; inhibition site
1097668008758	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1097668008759	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1097668008760	core domain interface [polypeptide binding]; other site
1097668008761	delta subunit interface [polypeptide binding]; other site
1097668008762	epsilon subunit interface [polypeptide binding]; other site
1097668008763	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1097668008764	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1097668008765	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1097668008766	beta subunit interaction interface [polypeptide binding]; other site
1097668008767	Walker A motif; other site
1097668008768	ATP binding site [chemical binding]; other site
1097668008769	Walker B motif; other site
1097668008770	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1097668008771	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1097668008772	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1097668008773	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1097668008774	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1097668008775	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1097668008776	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1097668008777	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1097668008778	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1097668008779	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1097668008780	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1097668008781	transmembrane helices; other site
1097668008782	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1097668008783	ParB-like nuclease domain; Region: ParBc; pfam02195
1097668008784	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097668008785	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668008786	P-loop; other site
1097668008787	Magnesium ion binding site [ion binding]; other site
1097668008788	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668008789	Magnesium ion binding site [ion binding]; other site
1097668008790	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1097668008791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668008792	S-adenosylmethionine binding site [chemical binding]; other site
1097668008793	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1097668008794	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1097668008795	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1097668008796	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1097668008797	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668008798	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668008799	Walker A/P-loop; other site
1097668008800	ATP binding site [chemical binding]; other site
1097668008801	Q-loop/lid; other site
1097668008802	ABC transporter signature motif; other site
1097668008803	Walker B; other site
1097668008804	D-loop; other site
1097668008805	H-loop/switch region; other site
1097668008806	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668008807	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668008808	TM-ABC transporter signature motif; other site
1097668008809	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668008810	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668008811	Walker A/P-loop; other site
1097668008812	ATP binding site [chemical binding]; other site
1097668008813	Q-loop/lid; other site
1097668008814	ABC transporter signature motif; other site
1097668008815	Walker B; other site
1097668008816	D-loop; other site
1097668008817	H-loop/switch region; other site
1097668008818	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668008819	TM-ABC transporter signature motif; other site
1097668008820	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668008821	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1097668008822	putative ligand binding site [chemical binding]; other site
1097668008823	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668008824	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
1097668008825	putative ligand binding site [chemical binding]; other site
1097668008826	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668008827	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668008828	TM-ABC transporter signature motif; other site
1097668008829	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668008830	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668008831	TM-ABC transporter signature motif; other site
1097668008832	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668008833	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1097668008834	putative ligand binding site [chemical binding]; other site
1097668008835	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668008836	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668008837	Walker A/P-loop; other site
1097668008838	ATP binding site [chemical binding]; other site
1097668008839	Q-loop/lid; other site
1097668008840	ABC transporter signature motif; other site
1097668008841	Walker B; other site
1097668008842	D-loop; other site
1097668008843	H-loop/switch region; other site
1097668008844	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668008845	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668008846	Walker A/P-loop; other site
1097668008847	ATP binding site [chemical binding]; other site
1097668008848	Q-loop/lid; other site
1097668008849	ABC transporter signature motif; other site
1097668008850	Walker B; other site
1097668008851	D-loop; other site
1097668008852	H-loop/switch region; other site
1097668008853	choline dehydrogenase; Validated; Region: PRK02106
1097668008854	lycopene cyclase; Region: lycopene_cycl; TIGR01789
1097668008855	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668008856	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668008857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668008858	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668008859	dimerization interface [polypeptide binding]; other site
1097668008860	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
1097668008861	putative active site [active]
1097668008862	putative metal binding residues [ion binding]; other site
1097668008863	signature motif; other site
1097668008864	putative triphosphate binding site [ion binding]; other site
1097668008865	dimer interface [polypeptide binding]; other site
1097668008866	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668008867	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1097668008868	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668008869	Protein of unknown function (DUF3717); Region: DUF3717; pfam12512
1097668008870	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668008871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668008872	active site
1097668008873	phosphorylation site [posttranslational modification]
1097668008874	intermolecular recognition site; other site
1097668008875	dimerization interface [polypeptide binding]; other site
1097668008876	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668008877	DNA binding site [nucleotide binding]
1097668008878	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1097668008879	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668008880	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1097668008881	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668008882	dimer interface [polypeptide binding]; other site
1097668008883	phosphorylation site [posttranslational modification]
1097668008884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668008885	ATP binding site [chemical binding]; other site
1097668008886	Mg2+ binding site [ion binding]; other site
1097668008887	G-X-G motif; other site
1097668008888	Proteins containing SET domain [General function prediction only]; Region: COG2940
1097668008889	SET domain; Region: SET; pfam00856
1097668008890	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097668008891	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1097668008892	active site
1097668008893	FMN binding site [chemical binding]; other site
1097668008894	substrate binding site [chemical binding]; other site
1097668008895	homotetramer interface [polypeptide binding]; other site
1097668008896	catalytic residue [active]
1097668008897	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1097668008898	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1097668008899	catalytic triad [active]
1097668008900	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668008901	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668008902	putative DNA binding site [nucleotide binding]; other site
1097668008903	putative Zn2+ binding site [ion binding]; other site
1097668008904	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
1097668008905	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1097668008906	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1097668008907	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1097668008908	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
1097668008909	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
1097668008910	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668008911	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097668008912	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1097668008913	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1097668008914	active site residue [active]
1097668008915	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097668008916	IHF dimer interface [polypeptide binding]; other site
1097668008917	IHF - DNA interface [nucleotide binding]; other site
1097668008918	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1097668008919	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668008920	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1097668008921	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1097668008922	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668008923	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668008924	catalytic residue [active]
1097668008925	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1097668008926	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1097668008927	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1097668008928	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1097668008929	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1097668008930	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1097668008931	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1097668008932	Walker A motif; other site
1097668008933	ATP binding site [chemical binding]; other site
1097668008934	Walker B motif; other site
1097668008935	type II secretion system protein F; Region: GspF; TIGR02120
1097668008936	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668008937	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668008938	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1097668008939	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1097668008940	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1097668008941	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
1097668008942	Type II transport protein GspH; Region: GspH; pfam12019
1097668008943	type II secretion system protein I; Region: gspI; TIGR01707
1097668008944	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1097668008945	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
1097668008946	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1097668008947	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
1097668008948	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1097668008949	GspL periplasmic domain; Region: GspL_C; pfam12693
1097668008950	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
1097668008951	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1097668008952	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668008953	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668008954	MarR family; Region: MarR_2; cl17246
1097668008955	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668008956	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008957	putative substrate translocation pore; other site
1097668008958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668008959	glutamate--cysteine ligase; Provisional; Region: PRK02107
1097668008960	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
1097668008961	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1097668008962	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668008963	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668008964	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1097668008965	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1097668008966	DNA binding site [nucleotide binding]
1097668008967	active site
1097668008968	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1097668008969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668008970	Walker A motif; other site
1097668008971	ATP binding site [chemical binding]; other site
1097668008972	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668008973	Walker B motif; other site
1097668008974	arginine finger; other site
1097668008975	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1097668008976	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1097668008977	active site
1097668008978	HslU subunit interaction site [polypeptide binding]; other site
1097668008979	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1097668008980	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1097668008981	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1097668008982	P-loop, Walker A motif; other site
1097668008983	Base recognition motif; other site
1097668008984	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1097668008985	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1097668008986	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1097668008987	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1097668008988	putative RNA binding site [nucleotide binding]; other site
1097668008989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668008990	S-adenosylmethionine binding site [chemical binding]; other site
1097668008991	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1097668008992	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668008993	active site
1097668008994	DNA binding site [nucleotide binding]
1097668008995	Int/Topo IB signature motif; other site
1097668008996	Protein of unknown function, DUF484; Region: DUF484; cl17449
1097668008997	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1097668008998	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1097668008999	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1097668009000	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1097668009001	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1097668009002	putative acyl-acceptor binding pocket; other site
1097668009003	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1097668009004	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1097668009005	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1097668009006	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1097668009007	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097668009008	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1097668009009	FMN binding site [chemical binding]; other site
1097668009010	active site
1097668009011	substrate binding site [chemical binding]; other site
1097668009012	catalytic residue [active]
1097668009013	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1097668009014	Protein of unknown function (DUF3185); Region: DUF3185; pfam11381
1097668009015	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668009016	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668009017	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668009018	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668009019	active site
1097668009020	catalytic tetrad [active]
1097668009021	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668009022	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1097668009023	FAD binding pocket [chemical binding]; other site
1097668009024	FAD binding motif [chemical binding]; other site
1097668009025	phosphate binding motif [ion binding]; other site
1097668009026	beta-alpha-beta structure motif; other site
1097668009027	NAD binding pocket [chemical binding]; other site
1097668009028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097668009029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668009030	ATP binding site [chemical binding]; other site
1097668009031	Mg2+ binding site [ion binding]; other site
1097668009032	G-X-G motif; other site
1097668009033	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668009034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668009035	active site
1097668009036	phosphorylation site [posttranslational modification]
1097668009037	intermolecular recognition site; other site
1097668009038	dimerization interface [polypeptide binding]; other site
1097668009039	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668009040	DNA binding residues [nucleotide binding]
1097668009041	dimerization interface [polypeptide binding]; other site
1097668009042	amino acid transporter; Region: 2A0306; TIGR00909
1097668009043	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1097668009044	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668009045	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
1097668009046	catalytic loop [active]
1097668009047	iron binding site [ion binding]; other site
1097668009048	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668009049	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668009050	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668009051	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668009052	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1097668009053	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1097668009054	MoxR-like ATPases [General function prediction only]; Region: COG0714
1097668009055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668009056	Walker A motif; other site
1097668009057	ATP binding site [chemical binding]; other site
1097668009058	Walker B motif; other site
1097668009059	arginine finger; other site
1097668009060	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1097668009061	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1097668009062	metal ion-dependent adhesion site (MIDAS); other site
1097668009063	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1097668009064	putative hydrophobic ligand binding site [chemical binding]; other site
1097668009065	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1097668009066	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1097668009067	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1097668009068	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1097668009069	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1097668009070	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1097668009071	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
1097668009072	BRO family, N-terminal domain; Region: Bro-N; pfam02498
1097668009073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
1097668009074	serine/threonine protein kinase; Provisional; Region: PRK11768
1097668009075	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1097668009076	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1097668009077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009078	Dienelactone hydrolase family; Region: DLH; pfam01738
1097668009079	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668009080	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668009081	dimerization interface [polypeptide binding]; other site
1097668009082	ligand binding site [chemical binding]; other site
1097668009083	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
1097668009084	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
1097668009085	H-NS histone family; Region: Histone_HNS; pfam00816
1097668009086	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1097668009087	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1097668009088	Cation efflux family; Region: Cation_efflux; pfam01545
1097668009089	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668009090	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668009091	putative DNA binding site [nucleotide binding]; other site
1097668009092	putative Zn2+ binding site [ion binding]; other site
1097668009093	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668009094	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1097668009095	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1097668009096	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1097668009097	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1097668009098	Predicted methyltransferases [General function prediction only]; Region: COG0313
1097668009099	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1097668009100	putative SAM binding site [chemical binding]; other site
1097668009101	putative homodimer interface [polypeptide binding]; other site
1097668009102	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1097668009103	active site
1097668009104	dimer interface [polypeptide binding]; other site
1097668009105	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1097668009106	BON domain; Region: BON; pfam04972
1097668009107	Cytochrome c; Region: Cytochrom_C; cl11414
1097668009108	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
1097668009109	dimer interface [polypeptide binding]; other site
1097668009110	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668009111	metal binding site [ion binding]; metal-binding site
1097668009112	YaeQ protein; Region: YaeQ; pfam07152
1097668009113	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668009114	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1097668009115	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1097668009116	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1097668009117	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1097668009118	G1 box; other site
1097668009119	GTP/Mg2+ binding site [chemical binding]; other site
1097668009120	Switch I region; other site
1097668009121	G2 box; other site
1097668009122	Switch II region; other site
1097668009123	G3 box; other site
1097668009124	G4 box; other site
1097668009125	G5 box; other site
1097668009126	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1097668009127	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668009128	sequence-specific DNA binding site [nucleotide binding]; other site
1097668009129	salt bridge; other site
1097668009130	membrane protein insertase; Provisional; Region: PRK01318
1097668009131	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1097668009132	hypothetical protein; Validated; Region: PRK00041
1097668009133	Ribonuclease P; Region: Ribonuclease_P; cl00457
1097668009134	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1097668009135	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1097668009136	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
1097668009137	IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483
1097668009138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668009139	Walker A motif; other site
1097668009140	ATP binding site [chemical binding]; other site
1097668009141	Walker B motif; other site
1097668009142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1097668009143	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1097668009144	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
1097668009145	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
1097668009146	Int/Topo IB signature motif; other site
1097668009147	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1097668009148	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668009149	active site
1097668009150	DNA binding site [nucleotide binding]
1097668009151	Int/Topo IB signature motif; other site
1097668009152	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1097668009153	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1097668009154	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1097668009155	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1097668009156	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1097668009157	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1097668009158	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1097668009159	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668009160	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668009161	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1097668009162	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1097668009163	Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and    vesicular transport]; Region: IcmF; COG3523
1097668009164	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1097668009165	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1097668009166	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1097668009167	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1097668009168	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1097668009169	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1097668009170	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1097668009171	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1097668009172	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668009173	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668009174	ligand binding site [chemical binding]; other site
1097668009175	hypothetical protein; Provisional; Region: PRK06208
1097668009176	intersubunit interface [polypeptide binding]; other site
1097668009177	active site
1097668009178	Zn2+ binding site [ion binding]; other site
1097668009179	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668009180	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009181	putative substrate translocation pore; other site
1097668009182	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1097668009183	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668009184	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668009185	hydrophobic ligand binding site; other site
1097668009186	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668009187	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668009188	FMN-binding pocket [chemical binding]; other site
1097668009189	flavin binding motif; other site
1097668009190	phosphate binding motif [ion binding]; other site
1097668009191	beta-alpha-beta structure motif; other site
1097668009192	NAD binding pocket [chemical binding]; other site
1097668009193	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668009194	catalytic loop [active]
1097668009195	iron binding site [ion binding]; other site
1097668009196	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668009197	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668009198	DNA-binding site [nucleotide binding]; DNA binding site
1097668009199	FCD domain; Region: FCD; pfam07729
1097668009200	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668009201	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009202	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668009203	dimerization interface [polypeptide binding]; other site
1097668009204	substrate binding pocket [chemical binding]; other site
1097668009205	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668009206	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009207	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1097668009208	putative dimerization interface [polypeptide binding]; other site
1097668009209	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1097668009210	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097668009211	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1097668009212	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668009213	citrate-proton symporter; Provisional; Region: PRK15075
1097668009214	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009215	putative substrate translocation pore; other site
1097668009216	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668009217	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668009218	conserved cys residue [active]
1097668009219	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009220	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1097668009221	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668009222	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1097668009223	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1097668009224	substrate binding site [chemical binding]; other site
1097668009225	catalytic Zn binding site [ion binding]; other site
1097668009226	NAD binding site [chemical binding]; other site
1097668009227	structural Zn binding site [ion binding]; other site
1097668009228	dimer interface [polypeptide binding]; other site
1097668009229	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097668009230	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1097668009231	FMN binding site [chemical binding]; other site
1097668009232	active site
1097668009233	substrate binding site [chemical binding]; other site
1097668009234	catalytic residue [active]
1097668009235	Predicted transcriptional regulators [Transcription]; Region: COG1733
1097668009236	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668009237	putative DNA binding site [nucleotide binding]; other site
1097668009238	dimerization interface [polypeptide binding]; other site
1097668009239	putative Zn2+ binding site [ion binding]; other site
1097668009240	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097668009241	Zn2+ binding site [ion binding]; other site
1097668009242	Mg2+ binding site [ion binding]; other site
1097668009243	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668009244	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668009245	DNA-binding site [nucleotide binding]; DNA binding site
1097668009246	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668009247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668009248	homodimer interface [polypeptide binding]; other site
1097668009249	catalytic residue [active]
1097668009250	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1097668009251	putative FMN binding site [chemical binding]; other site
1097668009252	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1097668009253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009254	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668009255	substrate binding pocket [chemical binding]; other site
1097668009256	dimerization interface [polypeptide binding]; other site
1097668009257	amidase; Provisional; Region: PRK07487
1097668009258	Amidase; Region: Amidase; cl11426
1097668009259	benzoate transport; Region: 2A0115; TIGR00895
1097668009260	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009261	putative substrate translocation pore; other site
1097668009262	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009263	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668009264	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668009265	trimer interface [polypeptide binding]; other site
1097668009266	eyelet of channel; other site
1097668009267	Cupin domain; Region: Cupin_2; pfam07883
1097668009268	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1097668009269	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668009270	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1097668009271	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1097668009272	dimer interface [polypeptide binding]; other site
1097668009273	active site
1097668009274	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1097668009275	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668009276	catalytic loop [active]
1097668009277	iron binding site [ion binding]; other site
1097668009278	Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211
1097668009279	FAD binding pocket [chemical binding]; other site
1097668009280	FAD binding motif [chemical binding]; other site
1097668009281	phosphate binding motif [ion binding]; other site
1097668009282	beta-alpha-beta structure motif; other site
1097668009283	NAD binding pocket [chemical binding]; other site
1097668009284	Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663
1097668009285	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
1097668009286	dimerization interface [polypeptide binding]; other site
1097668009287	putative path to active site cavity [active]
1097668009288	diiron center [ion binding]; other site
1097668009289	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
1097668009290	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
1097668009291	dimerization interface [polypeptide binding]; other site
1097668009292	Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099
1097668009293	Activator of aromatic catabolism; Region: XylR_N; pfam06505
1097668009294	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
1097668009295	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1097668009296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668009297	Walker A motif; other site
1097668009298	ATP binding site [chemical binding]; other site
1097668009299	Walker B motif; other site
1097668009300	arginine finger; other site
1097668009301	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668009302	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1097668009303	Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424
1097668009304	PAS domain; Region: PAS_9; pfam13426
1097668009305	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668009306	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668009307	metal binding site [ion binding]; metal-binding site
1097668009308	active site
1097668009309	I-site; other site
1097668009310	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668009311	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009312	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668009313	putative substrate translocation pore; other site
1097668009314	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1097668009315	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1097668009316	phosphate binding site [ion binding]; other site
1097668009317	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1097668009318	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1097668009319	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1097668009320	NAD binding site [chemical binding]; other site
1097668009321	catalytic Zn binding site [ion binding]; other site
1097668009322	substrate binding site [chemical binding]; other site
1097668009323	structural Zn binding site [ion binding]; other site
1097668009324	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1097668009325	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1097668009326	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668009327	DNA-binding site [nucleotide binding]; DNA binding site
1097668009328	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668009329	FCD domain; Region: FCD; pfam07729
1097668009330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668009331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668009332	dimer interface [polypeptide binding]; other site
1097668009333	phosphorylation site [posttranslational modification]
1097668009334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668009335	ATP binding site [chemical binding]; other site
1097668009336	Mg2+ binding site [ion binding]; other site
1097668009337	G-X-G motif; other site
1097668009338	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1097668009339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668009340	active site
1097668009341	phosphorylation site [posttranslational modification]
1097668009342	intermolecular recognition site; other site
1097668009343	dimerization interface [polypeptide binding]; other site
1097668009344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668009345	Walker A motif; other site
1097668009346	ATP binding site [chemical binding]; other site
1097668009347	Walker B motif; other site
1097668009348	arginine finger; other site
1097668009349	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668009350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009351	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668009352	putative substrate translocation pore; other site
1097668009353	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668009354	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668009355	active site
1097668009356	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
1097668009357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668009358	NAD(P) binding site [chemical binding]; other site
1097668009359	active site
1097668009360	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097668009361	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668009362	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
1097668009363	substrate binding site [chemical binding]; other site
1097668009364	oxyanion hole (OAH) forming residues; other site
1097668009365	trimer interface [polypeptide binding]; other site
1097668009366	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1097668009367	Coenzyme A transferase; Region: CoA_trans; smart00882
1097668009368	Coenzyme A transferase; Region: CoA_trans; cl17247
1097668009369	Coenzyme A transferase; Region: CoA_trans; smart00882
1097668009370	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1097668009371	Coenzyme A transferase; Region: CoA_trans; cl17247
1097668009372	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668009373	active site 2 [active]
1097668009374	active site 1 [active]
1097668009375	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668009376	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668009377	active site
1097668009378	catalytic tetrad [active]
1097668009379	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668009380	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668009381	substrate binding site [chemical binding]; other site
1097668009382	oxyanion hole (OAH) forming residues; other site
1097668009383	trimer interface [polypeptide binding]; other site
1097668009384	Protein of unknown function (DUF993); Region: DUF993; pfam06187
1097668009385	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668009386	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
1097668009387	NAD(P) binding site [chemical binding]; other site
1097668009388	active site
1097668009389	DctM-like transporters; Region: DctM; pfam06808
1097668009390	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1097668009391	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1097668009392	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1097668009393	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1097668009394	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668009395	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668009396	DNA binding site [nucleotide binding]
1097668009397	domain linker motif; other site
1097668009398	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1097668009399	putative dimerization interface [polypeptide binding]; other site
1097668009400	putative ligand binding site [chemical binding]; other site
1097668009401	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1097668009402	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668009403	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668009404	shikimate binding site; other site
1097668009405	NAD(P) binding site [chemical binding]; other site
1097668009406	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668009407	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668009408	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668009409	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668009410	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009411	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668009412	putative dimerization interface [polypeptide binding]; other site
1097668009413	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1097668009414	substrate binding site [chemical binding]; other site
1097668009415	ligand binding site [chemical binding]; other site
1097668009416	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1097668009417	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1097668009418	substrate binding site [chemical binding]; other site
1097668009419	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1097668009420	tartrate dehydrogenase; Region: TTC; TIGR02089
1097668009421	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668009422	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668009423	Walker A/P-loop; other site
1097668009424	ATP binding site [chemical binding]; other site
1097668009425	Q-loop/lid; other site
1097668009426	ABC transporter signature motif; other site
1097668009427	Walker B; other site
1097668009428	D-loop; other site
1097668009429	H-loop/switch region; other site
1097668009430	TOBE domain; Region: TOBE_2; pfam08402
1097668009431	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1097668009432	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668009433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668009434	dimer interface [polypeptide binding]; other site
1097668009435	conserved gate region; other site
1097668009436	putative PBP binding loops; other site
1097668009437	ABC-ATPase subunit interface; other site
1097668009438	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668009439	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668009440	dimer interface [polypeptide binding]; other site
1097668009441	conserved gate region; other site
1097668009442	putative PBP binding loops; other site
1097668009443	ABC-ATPase subunit interface; other site
1097668009444	Protein of unknown function, DUF417; Region: DUF417; cl01162
1097668009445	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097668009446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668009447	Coenzyme A binding pocket [chemical binding]; other site
1097668009448	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097668009449	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1097668009450	putative NAD(P) binding site [chemical binding]; other site
1097668009451	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1097668009452	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1097668009453	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1097668009454	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1097668009455	dimer interface [polypeptide binding]; other site
1097668009456	FMN binding site [chemical binding]; other site
1097668009457	Cupin; Region: Cupin_6; pfam12852
1097668009458	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668009459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009461	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668009462	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668009463	NAD(P) binding site [chemical binding]; other site
1097668009464	active site
1097668009465	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1097668009466	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1097668009467	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668009468	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668009469	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668009470	DNA-binding site [nucleotide binding]; DNA binding site
1097668009471	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668009472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668009473	homodimer interface [polypeptide binding]; other site
1097668009474	catalytic residue [active]
1097668009475	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1097668009476	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
1097668009477	DNA binding residues [nucleotide binding]
1097668009478	putative dimer interface [polypeptide binding]; other site
1097668009479	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
1097668009480	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668009481	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1097668009482	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1097668009483	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1097668009484	Sulfatase; Region: Sulfatase; pfam00884
1097668009485	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668009486	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009487	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668009488	dimerization interface [polypeptide binding]; other site
1097668009489	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009490	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668009491	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009492	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668009493	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1097668009494	catalytic triad [active]
1097668009495	conserved cis-peptide bond; other site
1097668009496	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668009497	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668009498	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1097668009499	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668009500	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1097668009501	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668009502	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009503	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
1097668009504	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1097668009505	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668009506	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009507	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668009508	dimerization interface [polypeptide binding]; other site
1097668009509	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1097668009510	homotrimer interaction site [polypeptide binding]; other site
1097668009511	putative active site [active]
1097668009512	Rrf2 family protein; Region: rrf2_super; TIGR00738
1097668009513	Transcriptional regulator; Region: Rrf2; pfam02082
1097668009514	Transcriptional regulator; Region: Rrf2; cl17282
1097668009515	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668009516	enoyl-CoA hydratase; Provisional; Region: PRK06688
1097668009517	substrate binding site [chemical binding]; other site
1097668009518	oxyanion hole (OAH) forming residues; other site
1097668009519	trimer interface [polypeptide binding]; other site
1097668009520	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1097668009521	classical (c) SDRs; Region: SDR_c; cd05233
1097668009522	NAD(P) binding site [chemical binding]; other site
1097668009523	active site
1097668009524	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668009525	Class I aldolases; Region: Aldolase_Class_I; cl17187
1097668009526	catalytic residue [active]
1097668009527	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1097668009528	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1097668009529	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1097668009530	NAD(P) binding pocket [chemical binding]; other site
1097668009531	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1097668009532	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009533	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668009534	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668009535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668009536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668009537	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097668009538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668009539	NAD(P) binding site [chemical binding]; other site
1097668009540	active site
1097668009541	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1097668009542	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668009543	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668009544	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668009545	trimer interface [polypeptide binding]; other site
1097668009546	eyelet of channel; other site
1097668009547	benzoate transport; Region: 2A0115; TIGR00895
1097668009548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009549	putative substrate translocation pore; other site
1097668009550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009551	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1097668009552	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1097668009553	active site
1097668009554	non-prolyl cis peptide bond; other site
1097668009555	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668009556	MarR family; Region: MarR_2; pfam12802
1097668009557	beta-ketothiolase; Provisional; Region: PRK09051
1097668009558	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668009559	dimer interface [polypeptide binding]; other site
1097668009560	active site
1097668009561	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
1097668009562	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
1097668009563	putative catalytic residue [active]
1097668009564	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097668009565	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
1097668009566	putative NAD(P) binding site [chemical binding]; other site
1097668009567	active site
1097668009568	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097668009569	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668009570	NAD(P) binding site [chemical binding]; other site
1097668009571	active site
1097668009572	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668009573	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1097668009574	putative C-terminal domain interface [polypeptide binding]; other site
1097668009575	putative GSH binding site (G-site) [chemical binding]; other site
1097668009576	putative dimer interface [polypeptide binding]; other site
1097668009577	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668009578	dimer interface [polypeptide binding]; other site
1097668009579	N-terminal domain interface [polypeptide binding]; other site
1097668009580	substrate binding pocket (H-site) [chemical binding]; other site
1097668009581	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668009582	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668009583	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1097668009584	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1097668009585	ligand binding site [chemical binding]; other site
1097668009586	homodimer interface [polypeptide binding]; other site
1097668009587	NAD(P) binding site [chemical binding]; other site
1097668009588	trimer interface B [polypeptide binding]; other site
1097668009589	trimer interface A [polypeptide binding]; other site
1097668009590	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1097668009591	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1097668009592	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1097668009593	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1097668009594	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668009595	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668009596	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1097668009597	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668009598	C-terminal domain interface [polypeptide binding]; other site
1097668009599	GSH binding site (G-site) [chemical binding]; other site
1097668009600	dimer interface [polypeptide binding]; other site
1097668009601	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668009602	N-terminal domain interface [polypeptide binding]; other site
1097668009603	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1097668009604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009605	putative substrate translocation pore; other site
1097668009606	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1097668009607	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1097668009608	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668009609	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668009610	DNA-binding site [nucleotide binding]; DNA binding site
1097668009611	FCD domain; Region: FCD; pfam07729
1097668009612	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668009613	MarR family; Region: MarR_2; cl17246
1097668009614	dihydroorotase; Provisional; Region: PRK09237
1097668009615	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668009616	active site
1097668009617	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668009618	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668009619	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668009620	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
1097668009621	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
1097668009622	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668009623	catalytic loop [active]
1097668009624	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1097668009625	iron binding site [ion binding]; other site
1097668009626	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668009627	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
1097668009628	putative hydrophobic ligand binding site [chemical binding]; other site
1097668009629	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
1097668009630	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
1097668009631	SnoaL-like domain; Region: SnoaL_3; pfam13474
1097668009632	amidase; Provisional; Region: PRK08310
1097668009633	indole-3-acetamide amidohydrolase; Region: PLN02722
1097668009634	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1097668009635	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668009636	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668009637	Walker A/P-loop; other site
1097668009638	ATP binding site [chemical binding]; other site
1097668009639	Q-loop/lid; other site
1097668009640	ABC transporter signature motif; other site
1097668009641	Walker B; other site
1097668009642	D-loop; other site
1097668009643	H-loop/switch region; other site
1097668009644	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
1097668009645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668009646	putative PBP binding loops; other site
1097668009647	dimer interface [polypeptide binding]; other site
1097668009648	ABC-ATPase subunit interface; other site
1097668009649	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668009650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668009651	dimer interface [polypeptide binding]; other site
1097668009652	conserved gate region; other site
1097668009653	putative PBP binding loops; other site
1097668009654	ABC-ATPase subunit interface; other site
1097668009655	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668009656	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668009657	substrate binding pocket [chemical binding]; other site
1097668009658	membrane-bound complex binding site; other site
1097668009659	hinge residues; other site
1097668009660	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1097668009661	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097668009662	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097668009663	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1097668009664	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1097668009665	benzoate transport; Region: 2A0115; TIGR00895
1097668009666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009667	putative substrate translocation pore; other site
1097668009668	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668009669	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668009670	trimer interface [polypeptide binding]; other site
1097668009671	eyelet of channel; other site
1097668009672	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668009673	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1097668009674	catalytic triad [active]
1097668009675	conserved cis-peptide bond; other site
1097668009676	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668009677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009678	putative substrate translocation pore; other site
1097668009679	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1097668009680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009681	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1097668009682	dimerization interface [polypeptide binding]; other site
1097668009683	substrate binding pocket [chemical binding]; other site
1097668009684	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009685	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668009686	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668009687	Putative cyclase; Region: Cyclase; pfam04199
1097668009688	Flavin Reductases; Region: FlaRed; cl00801
1097668009689	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1097668009690	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1097668009691	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1097668009692	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1097668009693	putative NAD(P) binding site [chemical binding]; other site
1097668009694	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1097668009695	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668009696	active site
1097668009697	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1097668009698	Aspartase; Region: Aspartase; cd01357
1097668009699	active sites [active]
1097668009700	tetramer interface [polypeptide binding]; other site
1097668009701	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1097668009702	active site
1097668009703	substrate binding pocket [chemical binding]; other site
1097668009704	dimer interface [polypeptide binding]; other site
1097668009705	allantoate amidohydrolase; Reviewed; Region: PRK12890
1097668009706	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668009707	active site
1097668009708	metal binding site [ion binding]; metal-binding site
1097668009709	dimer interface [polypeptide binding]; other site
1097668009710	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1097668009711	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1097668009712	heterodimer interface [polypeptide binding]; other site
1097668009713	active site
1097668009714	FMN binding site [chemical binding]; other site
1097668009715	homodimer interface [polypeptide binding]; other site
1097668009716	substrate binding site [chemical binding]; other site
1097668009717	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1097668009718	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1097668009719	FAD binding pocket [chemical binding]; other site
1097668009720	FAD binding motif [chemical binding]; other site
1097668009721	phosphate binding motif [ion binding]; other site
1097668009722	beta-alpha-beta structure motif; other site
1097668009723	NAD binding pocket [chemical binding]; other site
1097668009724	Iron coordination center [ion binding]; other site
1097668009725	benzoate transport; Region: 2A0115; TIGR00895
1097668009726	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009727	putative substrate translocation pore; other site
1097668009728	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668009729	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668009730	non-specific DNA binding site [nucleotide binding]; other site
1097668009731	salt bridge; other site
1097668009732	sequence-specific DNA binding site [nucleotide binding]; other site
1097668009733	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1097668009734	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1097668009735	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1097668009736	anti sigma factor interaction site; other site
1097668009737	regulatory phosphorylation site [posttranslational modification]; other site
1097668009738	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1097668009739	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
1097668009740	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1097668009741	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1097668009742	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1097668009743	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1097668009744	Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462
1097668009745	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1097668009746	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1097668009747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668009748	Walker A motif; other site
1097668009749	ATP binding site [chemical binding]; other site
1097668009750	Walker B motif; other site
1097668009751	arginine finger; other site
1097668009752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668009753	Walker A motif; other site
1097668009754	ATP binding site [chemical binding]; other site
1097668009755	Walker B motif; other site
1097668009756	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1097668009757	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1097668009758	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668009759	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668009760	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
1097668009761	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1097668009762	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668009763	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668009764	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1097668009765	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668009766	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668009767	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668009768	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668009769	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1097668009770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668009771	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
1097668009772	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
1097668009773	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1097668009774	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1097668009775	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1097668009776	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1097668009777	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
1097668009778	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1097668009779	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1097668009780	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
1097668009781	two-component response regulator VirG; Provisional; Region: PRK13856
1097668009782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668009783	active site
1097668009784	phosphorylation site [posttranslational modification]
1097668009785	intermolecular recognition site; other site
1097668009786	dimerization interface [polypeptide binding]; other site
1097668009787	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668009788	DNA binding site [nucleotide binding]
1097668009789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668009790	dimer interface [polypeptide binding]; other site
1097668009791	phosphorylation site [posttranslational modification]
1097668009792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668009793	ATP binding site [chemical binding]; other site
1097668009794	Mg2+ binding site [ion binding]; other site
1097668009795	G-X-G motif; other site
1097668009796	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
1097668009797	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1097668009798	Walker A/P-loop; other site
1097668009799	ATP binding site [chemical binding]; other site
1097668009800	Q-loop/lid; other site
1097668009801	ABC transporter signature motif; other site
1097668009802	Walker B; other site
1097668009803	D-loop; other site
1097668009804	H-loop/switch region; other site
1097668009805	MbtH-like protein; Region: MbtH; cl01279
1097668009806	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310
1097668009807	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1097668009808	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668009809	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668009810	acyl-activating enzyme (AAE) consensus motif; other site
1097668009811	AMP binding site [chemical binding]; other site
1097668009812	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1097668009813	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668009814	peptide synthase; Provisional; Region: PRK12467
1097668009815	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668009816	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1097668009817	acyl-activating enzyme (AAE) consensus motif; other site
1097668009818	AMP binding site [chemical binding]; other site
1097668009819	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668009820	acyl-activating enzyme (AAE) consensus motif; other site
1097668009821	AMP binding site [chemical binding]; other site
1097668009822	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668009823	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1097668009824	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668009825	acyl-activating enzyme (AAE) consensus motif; other site
1097668009826	AMP binding site [chemical binding]; other site
1097668009827	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668009828	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1097668009829	active site
1097668009830	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1097668009831	non-prolyl cis peptide bond; other site
1097668009832	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1097668009833	SPFH domain / Band 7 family; Region: Band_7; pfam01145
1097668009834	Condensation domain; Region: Condensation; pfam00668
1097668009835	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668009836	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668009837	acyl-activating enzyme (AAE) consensus motif; other site
1097668009838	AMP binding site [chemical binding]; other site
1097668009839	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668009840	Condensation domain; Region: Condensation; pfam00668
1097668009841	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668009842	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668009843	acyl-activating enzyme (AAE) consensus motif; other site
1097668009844	AMP binding site [chemical binding]; other site
1097668009845	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668009846	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1097668009847	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
1097668009848	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1097668009849	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668009850	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668009851	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668009852	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668009853	Walker A/P-loop; other site
1097668009854	ATP binding site [chemical binding]; other site
1097668009855	Q-loop/lid; other site
1097668009856	ABC transporter signature motif; other site
1097668009857	Walker B; other site
1097668009858	D-loop; other site
1097668009859	H-loop/switch region; other site
1097668009860	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668009861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668009862	dimer interface [polypeptide binding]; other site
1097668009863	conserved gate region; other site
1097668009864	putative PBP binding loops; other site
1097668009865	ABC-ATPase subunit interface; other site
1097668009866	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668009867	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668009868	substrate binding pocket [chemical binding]; other site
1097668009869	membrane-bound complex binding site; other site
1097668009870	hinge residues; other site
1097668009871	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1097668009872	agmatinase; Region: agmatinase; TIGR01230
1097668009873	oligomer interface [polypeptide binding]; other site
1097668009874	putative active site [active]
1097668009875	Mn binding site [ion binding]; other site
1097668009876	aminotransferase; Provisional; Region: PRK06105
1097668009877	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668009878	inhibitor-cofactor binding pocket; inhibition site
1097668009879	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668009880	catalytic residue [active]
1097668009881	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1097668009882	putative active site [active]
1097668009883	homotrimer interaction site [polypeptide binding]; other site
1097668009884	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668009885	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668009886	DNA-binding site [nucleotide binding]; DNA binding site
1097668009887	FCD domain; Region: FCD; pfam07729
1097668009888	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1097668009889	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1097668009890	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668009891	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668009892	active site
1097668009893	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1097668009894	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1097668009895	NAD binding site [chemical binding]; other site
1097668009896	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668009897	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668009898	[2Fe-2S] cluster binding site [ion binding]; other site
1097668009899	Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848
1097668009900	hydrophobic ligand binding site; other site
1097668009901	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668009902	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668009903	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668009904	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668009905	Walker A/P-loop; other site
1097668009906	ATP binding site [chemical binding]; other site
1097668009907	Q-loop/lid; other site
1097668009908	ABC transporter signature motif; other site
1097668009909	Walker B; other site
1097668009910	D-loop; other site
1097668009911	H-loop/switch region; other site
1097668009912	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668009913	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668009914	Walker A/P-loop; other site
1097668009915	ATP binding site [chemical binding]; other site
1097668009916	Q-loop/lid; other site
1097668009917	ABC transporter signature motif; other site
1097668009918	Walker B; other site
1097668009919	D-loop; other site
1097668009920	H-loop/switch region; other site
1097668009921	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668009922	TM-ABC transporter signature motif; other site
1097668009923	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668009924	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668009925	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668009926	TM-ABC transporter signature motif; other site
1097668009927	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668009928	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
1097668009929	DNA-binding site [nucleotide binding]; DNA binding site
1097668009930	FCD domain; Region: FCD; pfam07729
1097668009931	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
1097668009932	RNA polymerase sigma factor; Provisional; Region: PRK12536
1097668009933	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668009934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668009935	DNA binding residues [nucleotide binding]
1097668009936	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1097668009937	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1097668009938	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1097668009939	Moco binding site; other site
1097668009940	metal coordination site [ion binding]; other site
1097668009941	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668009942	MarR family; Region: MarR_2; pfam12802
1097668009943	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1097668009944	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
1097668009945	putative ion selectivity filter; other site
1097668009946	putative pore gating glutamate residue; other site
1097668009947	putative H+/Cl- coupling transport residue; other site
1097668009948	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668009949	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668009950	putative DNA binding site [nucleotide binding]; other site
1097668009951	putative Zn2+ binding site [ion binding]; other site
1097668009952	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668009953	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1097668009954	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668009955	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1097668009956	alpha subunit interface [polypeptide binding]; other site
1097668009957	active site
1097668009958	substrate binding site [chemical binding]; other site
1097668009959	Fe binding site [ion binding]; other site
1097668009960	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1097668009961	classical (c) SDRs; Region: SDR_c; cd05233
1097668009962	NAD(P) binding site [chemical binding]; other site
1097668009963	active site
1097668009964	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668009965	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668009966	FMN-binding pocket [chemical binding]; other site
1097668009967	flavin binding motif; other site
1097668009968	phosphate binding motif [ion binding]; other site
1097668009969	beta-alpha-beta structure motif; other site
1097668009970	NAD binding pocket [chemical binding]; other site
1097668009971	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668009972	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668009973	catalytic loop [active]
1097668009974	iron binding site [ion binding]; other site
1097668009975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009976	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668009977	putative substrate translocation pore; other site
1097668009978	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668009979	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668009980	trimer interface [polypeptide binding]; other site
1097668009981	eyelet of channel; other site
1097668009982	transcriptional activator TtdR; Provisional; Region: PRK09801
1097668009983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009984	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1097668009985	putative effector binding pocket; other site
1097668009986	putative dimerization interface [polypeptide binding]; other site
1097668009987	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668009988	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
1097668009989	putative active site pocket [active]
1097668009990	metal binding site [ion binding]; metal-binding site
1097668009991	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668009992	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668009993	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668009994	dimerization interface [polypeptide binding]; other site
1097668009995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668009996	putative substrate translocation pore; other site
1097668009997	Amino acid synthesis; Region: AA_synth; pfam06684
1097668009998	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668009999	non-specific DNA binding site [nucleotide binding]; other site
1097668010000	salt bridge; other site
1097668010001	sequence-specific DNA binding site [nucleotide binding]; other site
1097668010002	Cupin domain; Region: Cupin_2; pfam07883
1097668010003	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
1097668010004	intersubunit interface [polypeptide binding]; other site
1097668010005	active site
1097668010006	Zn2+ binding site [ion binding]; other site
1097668010007	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668010008	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668010009	inhibitor site; inhibition site
1097668010010	active site
1097668010011	dimer interface [polypeptide binding]; other site
1097668010012	catalytic residue [active]
1097668010013	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668010014	extended (e) SDRs; Region: SDR_e; cd08946
1097668010015	NAD(P) binding site [chemical binding]; other site
1097668010016	active site
1097668010017	substrate binding site [chemical binding]; other site
1097668010018	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668010019	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668010020	TM-ABC transporter signature motif; other site
1097668010021	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668010022	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668010023	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668010024	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668010025	Walker A/P-loop; other site
1097668010026	ATP binding site [chemical binding]; other site
1097668010027	Q-loop/lid; other site
1097668010028	ABC transporter signature motif; other site
1097668010029	Walker B; other site
1097668010030	D-loop; other site
1097668010031	H-loop/switch region; other site
1097668010032	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668010033	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
1097668010034	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668010035	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
1097668010036	ligand binding site [chemical binding]; other site
1097668010037	flexible hinge region; other site
1097668010038	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097668010039	non-specific DNA interactions [nucleotide binding]; other site
1097668010040	DNA binding site [nucleotide binding]
1097668010041	sequence specific DNA binding site [nucleotide binding]; other site
1097668010042	putative cAMP binding site [chemical binding]; other site
1097668010043	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668010044	DNA-binding site [nucleotide binding]; DNA binding site
1097668010045	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097668010046	UTRA domain; Region: UTRA; pfam07702
1097668010047	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1097668010048	Phosphotransferase enzyme family; Region: APH; pfam01636
1097668010049	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1097668010050	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1097668010051	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1097668010052	intersubunit interface [polypeptide binding]; other site
1097668010053	active site
1097668010054	Zn2+ binding site [ion binding]; other site
1097668010055	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668010056	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668010057	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668010058	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668010059	Walker A/P-loop; other site
1097668010060	ATP binding site [chemical binding]; other site
1097668010061	Q-loop/lid; other site
1097668010062	ABC transporter signature motif; other site
1097668010063	Walker B; other site
1097668010064	D-loop; other site
1097668010065	H-loop/switch region; other site
1097668010066	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668010067	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668010068	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668010069	TM-ABC transporter signature motif; other site
1097668010070	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1097668010071	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1097668010072	DAK2 domain; Region: Dak2; pfam02734
1097668010073	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1097668010074	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668010075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668010076	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1097668010077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010078	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668010079	putative substrate translocation pore; other site
1097668010080	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668010081	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1097668010082	NAD(P) binding site [chemical binding]; other site
1097668010083	homotetramer interface [polypeptide binding]; other site
1097668010084	homodimer interface [polypeptide binding]; other site
1097668010085	active site
1097668010086	short chain dehydrogenase; Provisional; Region: PRK12829
1097668010087	classical (c) SDRs; Region: SDR_c; cd05233
1097668010088	NAD(P) binding site [chemical binding]; other site
1097668010089	active site
1097668010090	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
1097668010091	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010092	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668010093	substrate binding pocket [chemical binding]; other site
1097668010094	dimerization interface [polypeptide binding]; other site
1097668010095	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668010096	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668010097	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668010098	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668010099	trimer interface [polypeptide binding]; other site
1097668010100	eyelet of channel; other site
1097668010101	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668010102	salicylate hydroxylase; Provisional; Region: PRK08163
1097668010103	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668010104	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668010105	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
1097668010106	Cupin domain; Region: Cupin_2; pfam07883
1097668010107	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668010108	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668010109	FMN-binding pocket [chemical binding]; other site
1097668010110	flavin binding motif; other site
1097668010111	phosphate binding motif [ion binding]; other site
1097668010112	beta-alpha-beta structure motif; other site
1097668010113	NAD binding pocket [chemical binding]; other site
1097668010114	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668010115	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668010116	catalytic loop [active]
1097668010117	iron binding site [ion binding]; other site
1097668010118	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668010119	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1097668010120	iron-sulfur cluster [ion binding]; other site
1097668010121	[2Fe-2S] cluster binding site [ion binding]; other site
1097668010122	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1097668010123	alpha subunit interface [polypeptide binding]; other site
1097668010124	active site
1097668010125	substrate binding site [chemical binding]; other site
1097668010126	Fe binding site [ion binding]; other site
1097668010127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010128	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668010129	putative substrate translocation pore; other site
1097668010130	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668010131	MarR family; Region: MarR_2; pfam12802
1097668010132	cysteine desulfurase; Provisional; Region: PRK14012
1097668010133	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1097668010134	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668010135	catalytic residue [active]
1097668010136	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1097668010137	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
1097668010138	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1097668010139	amidase; Provisional; Region: PRK07056
1097668010140	Amidase; Region: Amidase; cl11426
1097668010141	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668010142	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1097668010143	putative ligand binding site [chemical binding]; other site
1097668010144	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
1097668010145	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668010146	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668010147	Walker A/P-loop; other site
1097668010148	ATP binding site [chemical binding]; other site
1097668010149	Q-loop/lid; other site
1097668010150	ABC transporter signature motif; other site
1097668010151	Walker B; other site
1097668010152	D-loop; other site
1097668010153	H-loop/switch region; other site
1097668010154	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668010155	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668010156	Walker A/P-loop; other site
1097668010157	ATP binding site [chemical binding]; other site
1097668010158	Q-loop/lid; other site
1097668010159	ABC transporter signature motif; other site
1097668010160	Walker B; other site
1097668010161	D-loop; other site
1097668010162	H-loop/switch region; other site
1097668010163	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668010164	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668010165	TM-ABC transporter signature motif; other site
1097668010166	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668010167	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668010168	TM-ABC transporter signature motif; other site
1097668010169	short chain dehydrogenase; Provisional; Region: PRK06500
1097668010170	classical (c) SDRs; Region: SDR_c; cd05233
1097668010171	NAD(P) binding site [chemical binding]; other site
1097668010172	active site
1097668010173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010174	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668010175	putative effector binding pocket; other site
1097668010176	dimerization interface [polypeptide binding]; other site
1097668010177	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1097668010178	metal ion-dependent adhesion site (MIDAS); other site
1097668010179	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1097668010180	metal ion-dependent adhesion site (MIDAS); other site
1097668010181	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1097668010182	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1097668010183	metal ion-dependent adhesion site (MIDAS); other site
1097668010184	MoxR-like ATPases [General function prediction only]; Region: COG0714
1097668010185	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1097668010186	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1097668010187	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1097668010188	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1097668010189	benzoate transport; Region: 2A0115; TIGR00895
1097668010190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010191	putative substrate translocation pore; other site
1097668010192	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1097668010193	succinic semialdehyde dehydrogenase; Region: PLN02278
1097668010194	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668010195	tetramerization interface [polypeptide binding]; other site
1097668010196	NAD(P) binding site [chemical binding]; other site
1097668010197	catalytic residues [active]
1097668010198	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
1097668010199	Flavoprotein; Region: Flavoprotein; pfam02441
1097668010200	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1097668010201	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668010202	substrate binding site [chemical binding]; other site
1097668010203	oxyanion hole (OAH) forming residues; other site
1097668010204	trimer interface [polypeptide binding]; other site
1097668010205	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668010206	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668010207	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668010208	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
1097668010209	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668010210	catalytic loop [active]
1097668010211	iron binding site [ion binding]; other site
1097668010212	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668010213	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1097668010214	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1097668010215	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
1097668010216	putative hydrophobic ligand binding site [chemical binding]; other site
1097668010217	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1097668010218	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1097668010219	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1097668010220	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668010221	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668010222	DNA-binding site [nucleotide binding]; DNA binding site
1097668010223	FCD domain; Region: FCD; pfam07729
1097668010224	benzoate transport; Region: 2A0115; TIGR00895
1097668010225	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010226	putative substrate translocation pore; other site
1097668010227	Permease family; Region: Xan_ur_permease; pfam00860
1097668010228	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668010229	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668010230	trimer interface [polypeptide binding]; other site
1097668010231	eyelet of channel; other site
1097668010232	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668010233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010234	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668010235	putative substrate translocation pore; other site
1097668010236	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
1097668010237	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1097668010238	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010239	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1097668010240	putative dimerization interface [polypeptide binding]; other site
1097668010241	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1097668010242	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668010243	acyl-activating enzyme (AAE) consensus motif; other site
1097668010244	AMP binding site [chemical binding]; other site
1097668010245	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1097668010246	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668010247	N-terminal domain interface [polypeptide binding]; other site
1097668010248	dimer interface [polypeptide binding]; other site
1097668010249	substrate binding pocket (H-site) [chemical binding]; other site
1097668010250	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010251	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010252	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668010253	putative effector binding pocket; other site
1097668010254	dimerization interface [polypeptide binding]; other site
1097668010255	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097668010256	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1097668010257	putative catalytic residues [active]
1097668010258	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010260	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668010261	putative effector binding pocket; other site
1097668010262	dimerization interface [polypeptide binding]; other site
1097668010263	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668010264	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1097668010265	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668010266	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668010267	substrate binding pocket [chemical binding]; other site
1097668010268	membrane-bound complex binding site; other site
1097668010269	hinge residues; other site
1097668010270	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668010271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010272	dimer interface [polypeptide binding]; other site
1097668010273	conserved gate region; other site
1097668010274	putative PBP binding loops; other site
1097668010275	ABC-ATPase subunit interface; other site
1097668010276	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668010277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010278	dimer interface [polypeptide binding]; other site
1097668010279	conserved gate region; other site
1097668010280	putative PBP binding loops; other site
1097668010281	ABC-ATPase subunit interface; other site
1097668010282	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668010283	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668010284	Walker A/P-loop; other site
1097668010285	ATP binding site [chemical binding]; other site
1097668010286	Q-loop/lid; other site
1097668010287	ABC transporter signature motif; other site
1097668010288	Walker B; other site
1097668010289	D-loop; other site
1097668010290	H-loop/switch region; other site
1097668010291	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668010292	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1097668010293	active site pocket [active]
1097668010294	ornithine cyclodeaminase; Validated; Region: PRK06141
1097668010295	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1097668010296	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668010297	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668010298	conserved cys residue [active]
1097668010299	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668010300	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668010301	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668010302	metal binding site [ion binding]; metal-binding site
1097668010303	active site
1097668010304	I-site; other site
1097668010305	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1097668010306	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1097668010307	ATP binding site [chemical binding]; other site
1097668010308	Mg++ binding site [ion binding]; other site
1097668010309	motif III; other site
1097668010310	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668010311	nucleotide binding region [chemical binding]; other site
1097668010312	ATP-binding site [chemical binding]; other site
1097668010313	Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865
1097668010314	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668010315	Bacterial transcriptional activator domain; Region: BTAD; smart01043
1097668010316	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668010317	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1097668010318	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668010319	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668010320	DNA-binding site [nucleotide binding]; DNA binding site
1097668010321	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668010322	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668010323	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1097668010324	putative ligand binding site [chemical binding]; other site
1097668010325	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668010326	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668010327	TM-ABC transporter signature motif; other site
1097668010328	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668010329	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668010330	TM-ABC transporter signature motif; other site
1097668010331	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668010332	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668010333	Walker A/P-loop; other site
1097668010334	ATP binding site [chemical binding]; other site
1097668010335	Q-loop/lid; other site
1097668010336	ABC transporter signature motif; other site
1097668010337	Walker B; other site
1097668010338	D-loop; other site
1097668010339	H-loop/switch region; other site
1097668010340	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668010341	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668010342	Walker A/P-loop; other site
1097668010343	ATP binding site [chemical binding]; other site
1097668010344	Q-loop/lid; other site
1097668010345	ABC transporter signature motif; other site
1097668010346	Walker B; other site
1097668010347	D-loop; other site
1097668010348	H-loop/switch region; other site
1097668010349	allantoate amidohydrolase; Reviewed; Region: PRK12893
1097668010350	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668010351	active site
1097668010352	metal binding site [ion binding]; metal-binding site
1097668010353	dimer interface [polypeptide binding]; other site
1097668010354	Uncharacterized conserved protein [Function unknown]; Region: COG5476
1097668010355	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
1097668010356	MlrC C-terminus; Region: MlrC_C; pfam07171
1097668010357	Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128
1097668010358	Protein of unknown function (DUF3455); Region: DUF3455; pfam11937
1097668010359	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
1097668010360	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1097668010361	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1097668010362	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
1097668010363	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1097668010364	Protein of unknown function (DUF796); Region: DUF796; pfam05638
1097668010365	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1097668010366	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1097668010367	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1097668010368	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1097668010369	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1097668010370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668010371	Walker A motif; other site
1097668010372	ATP binding site [chemical binding]; other site
1097668010373	Walker B motif; other site
1097668010374	arginine finger; other site
1097668010375	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668010376	Walker A motif; other site
1097668010377	ATP binding site [chemical binding]; other site
1097668010378	Walker B motif; other site
1097668010379	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1097668010380	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1097668010381	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668010382	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668010383	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
1097668010384	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1097668010385	phosphopeptide binding site; other site
1097668010386	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1097668010387	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1097668010388	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
1097668010389	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668010390	ligand binding site [chemical binding]; other site
1097668010391	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1097668010392	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1097668010393	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1097668010394	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1097668010395	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
1097668010396	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1097668010397	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1097668010398	active site
1097668010399	ATP binding site [chemical binding]; other site
1097668010400	substrate binding site [chemical binding]; other site
1097668010401	activation loop (A-loop); other site
1097668010402	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1097668010403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668010404	dimerization interface [polypeptide binding]; other site
1097668010405	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1097668010406	Putative zinc-finger; Region: zf-HC2; pfam13490
1097668010407	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1097668010408	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668010409	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668010410	DNA binding residues [nucleotide binding]
1097668010411	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
1097668010412	putative heme binding pocket [chemical binding]; other site
1097668010413	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1097668010414	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1097668010415	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1097668010416	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1097668010417	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010418	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668010419	putative substrate translocation pore; other site
1097668010420	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668010421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668010422	NAD(P) binding site [chemical binding]; other site
1097668010423	active site
1097668010424	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668010425	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668010426	active site
1097668010427	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1097668010428	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1097668010429	putative ligand binding site [chemical binding]; other site
1097668010430	NAD binding site [chemical binding]; other site
1097668010431	catalytic site [active]
1097668010432	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668010433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010434	putative substrate translocation pore; other site
1097668010435	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668010436	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668010437	inhibitor site; inhibition site
1097668010438	active site
1097668010439	dimer interface [polypeptide binding]; other site
1097668010440	catalytic residue [active]
1097668010441	Transposase domain (DUF772); Region: DUF772; pfam05598
1097668010442	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1097668010443	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1097668010444	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010445	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010446	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
1097668010447	putative dimerization interface [polypeptide binding]; other site
1097668010448	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1097668010449	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668010450	active site pocket [active]
1097668010451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668010452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668010453	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1097668010454	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1097668010455	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1097668010456	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668010457	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668010458	dimerization interface [polypeptide binding]; other site
1097668010459	ligand binding site [chemical binding]; other site
1097668010460	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
1097668010461	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668010462	inhibitor-cofactor binding pocket; inhibition site
1097668010463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668010464	catalytic residue [active]
1097668010465	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
1097668010466	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097668010467	classical (c) SDRs; Region: SDR_c; cd05233
1097668010468	NAD(P) binding site [chemical binding]; other site
1097668010469	active site
1097668010470	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1097668010471	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668010472	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668010473	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668010474	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668010475	substrate binding site [chemical binding]; other site
1097668010476	oxyanion hole (OAH) forming residues; other site
1097668010477	trimer interface [polypeptide binding]; other site
1097668010478	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668010479	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668010480	fumarylacetoacetase; Region: PLN02856
1097668010481	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1097668010482	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668010483	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1097668010484	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1097668010485	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1097668010486	Na binding site [ion binding]; other site
1097668010487	Domain of unknown function DUF302; Region: DUF302; pfam03625
1097668010488	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
1097668010489	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668010490	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1097668010491	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1097668010492	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1097668010493	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010494	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668010495	dimerization interface [polypeptide binding]; other site
1097668010496	citrate-proton symporter; Provisional; Region: PRK15075
1097668010497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010498	putative substrate translocation pore; other site
1097668010499	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
1097668010500	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
1097668010501	metal binding site [ion binding]; metal-binding site
1097668010502	dimer interface [polypeptide binding]; other site
1097668010503	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668010504	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668010505	conserved cys residue [active]
1097668010506	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668010507	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1097668010508	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668010509	NAD(P) binding site [chemical binding]; other site
1097668010510	active site
1097668010511	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668010512	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668010513	DNA binding site [nucleotide binding]
1097668010514	domain linker motif; other site
1097668010515	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097668010516	dimerization interface [polypeptide binding]; other site
1097668010517	ligand binding site [chemical binding]; other site
1097668010518	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1097668010519	histidinol dehydrogenase; Region: hisD; TIGR00069
1097668010520	NAD binding site [chemical binding]; other site
1097668010521	dimerization interface [polypeptide binding]; other site
1097668010522	product binding site; other site
1097668010523	substrate binding site [chemical binding]; other site
1097668010524	zinc binding site [ion binding]; other site
1097668010525	catalytic residues [active]
1097668010526	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668010527	active site 2 [active]
1097668010528	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668010529	MarR family; Region: MarR_2; pfam12802
1097668010530	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668010531	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668010532	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010533	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668010534	putative substrate translocation pore; other site
1097668010535	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668010536	classical (c) SDRs; Region: SDR_c; cd05233
1097668010537	NAD(P) binding site [chemical binding]; other site
1097668010538	active site
1097668010539	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1097668010540	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668010541	metal binding site [ion binding]; metal-binding site
1097668010542	substrate binding pocket [chemical binding]; other site
1097668010543	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668010544	active site 1 [active]
1097668010545	dimer interface [polypeptide binding]; other site
1097668010546	hexamer interface [polypeptide binding]; other site
1097668010547	active site 2 [active]
1097668010548	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010549	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010550	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668010551	dimerization interface [polypeptide binding]; other site
1097668010552	glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511
1097668010553	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668010554	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1097668010555	catalytic triad [active]
1097668010556	conserved cis-peptide bond; other site
1097668010557	benzoate transport; Region: 2A0115; TIGR00895
1097668010558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010559	putative substrate translocation pore; other site
1097668010560	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668010561	sequence-specific DNA binding site [nucleotide binding]; other site
1097668010562	salt bridge; other site
1097668010563	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1097668010564	histidinol dehydrogenase; Region: hisD; TIGR00069
1097668010565	NAD binding site [chemical binding]; other site
1097668010566	dimerization interface [polypeptide binding]; other site
1097668010567	product binding site; other site
1097668010568	substrate binding site [chemical binding]; other site
1097668010569	zinc binding site [ion binding]; other site
1097668010570	catalytic residues [active]
1097668010571	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
1097668010572	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668010573	substrate binding pocket [chemical binding]; other site
1097668010574	membrane-bound complex binding site; other site
1097668010575	hinge residues; other site
1097668010576	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668010577	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010578	dimer interface [polypeptide binding]; other site
1097668010579	conserved gate region; other site
1097668010580	putative PBP binding loops; other site
1097668010581	ABC-ATPase subunit interface; other site
1097668010582	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010583	dimer interface [polypeptide binding]; other site
1097668010584	conserved gate region; other site
1097668010585	putative PBP binding loops; other site
1097668010586	ABC-ATPase subunit interface; other site
1097668010587	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668010588	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668010589	Walker A/P-loop; other site
1097668010590	ATP binding site [chemical binding]; other site
1097668010591	Q-loop/lid; other site
1097668010592	ABC transporter signature motif; other site
1097668010593	Walker B; other site
1097668010594	D-loop; other site
1097668010595	H-loop/switch region; other site
1097668010596	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668010597	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668010598	sequence-specific DNA binding site [nucleotide binding]; other site
1097668010599	salt bridge; other site
1097668010600	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668010601	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668010602	dimerization interface [polypeptide binding]; other site
1097668010603	ligand binding site [chemical binding]; other site
1097668010604	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1097668010605	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1097668010606	homodimer interface [polypeptide binding]; other site
1097668010607	substrate-cofactor binding pocket; other site
1097668010608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668010609	catalytic residue [active]
1097668010610	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1097668010611	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1097668010612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668010613	S-adenosylmethionine binding site [chemical binding]; other site
1097668010614	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
1097668010615	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1097668010616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668010617	S-adenosylmethionine binding site [chemical binding]; other site
1097668010618	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1097668010619	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1097668010620	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668010621	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1097668010622	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097668010623	DNA binding residues [nucleotide binding]
1097668010624	GAF domain; Region: GAF_3; pfam13492
1097668010625	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668010626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668010627	dimer interface [polypeptide binding]; other site
1097668010628	phosphorylation site [posttranslational modification]
1097668010629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668010630	ATP binding site [chemical binding]; other site
1097668010631	Mg2+ binding site [ion binding]; other site
1097668010632	G-X-G motif; other site
1097668010633	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668010634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668010635	active site
1097668010636	phosphorylation site [posttranslational modification]
1097668010637	intermolecular recognition site; other site
1097668010638	dimerization interface [polypeptide binding]; other site
1097668010639	PAS fold; Region: PAS_3; pfam08447
1097668010640	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668010641	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668010642	dimer interface [polypeptide binding]; other site
1097668010643	phosphorylation site [posttranslational modification]
1097668010644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668010645	ATP binding site [chemical binding]; other site
1097668010646	Mg2+ binding site [ion binding]; other site
1097668010647	G-X-G motif; other site
1097668010648	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668010649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668010650	active site
1097668010651	phosphorylation site [posttranslational modification]
1097668010652	intermolecular recognition site; other site
1097668010653	dimerization interface [polypeptide binding]; other site
1097668010654	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1097668010655	active site
1097668010656	homotetramer interface [polypeptide binding]; other site
1097668010657	homodimer interface [polypeptide binding]; other site
1097668010658	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1097668010659	Aspartase; Region: Aspartase; cd01357
1097668010660	active sites [active]
1097668010661	tetramer interface [polypeptide binding]; other site
1097668010662	aspartate racemase; Region: asp_race; TIGR00035
1097668010663	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
1097668010664	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1097668010665	aspartate racemase; Region: asp_race; TIGR00035
1097668010666	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097668010667	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1097668010668	cell density-dependent motility repressor; Provisional; Region: PRK10082
1097668010669	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010670	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668010671	dimerization interface [polypeptide binding]; other site
1097668010672	Family description; Region: UvrD_C_2; pfam13538
1097668010673	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
1097668010674	Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247
1097668010675	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668010676	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668010677	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668010678	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668010679	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668010680	active site
1097668010681	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1097668010682	CoA binding domain; Region: CoA_binding_2; pfam13380
1097668010683	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1097668010684	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1097668010685	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010686	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668010687	putative substrate translocation pore; other site
1097668010688	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1097668010689	nucleophile elbow; other site
1097668010690	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1097668010691	Patatin phospholipase; Region: DUF3734; pfam12536
1097668010692	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668010693	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668010694	substrate binding pocket [chemical binding]; other site
1097668010695	membrane-bound complex binding site; other site
1097668010696	hinge residues; other site
1097668010697	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668010698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010699	dimer interface [polypeptide binding]; other site
1097668010700	conserved gate region; other site
1097668010701	putative PBP binding loops; other site
1097668010702	ABC-ATPase subunit interface; other site
1097668010703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010704	dimer interface [polypeptide binding]; other site
1097668010705	conserved gate region; other site
1097668010706	putative PBP binding loops; other site
1097668010707	ABC-ATPase subunit interface; other site
1097668010708	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668010709	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668010710	Walker A/P-loop; other site
1097668010711	ATP binding site [chemical binding]; other site
1097668010712	Q-loop/lid; other site
1097668010713	ABC transporter signature motif; other site
1097668010714	Walker B; other site
1097668010715	D-loop; other site
1097668010716	H-loop/switch region; other site
1097668010717	allantoate amidohydrolase; Reviewed; Region: PRK09290
1097668010718	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668010719	active site
1097668010720	metal binding site [ion binding]; metal-binding site
1097668010721	dimer interface [polypeptide binding]; other site
1097668010722	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1097668010723	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1097668010724	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1097668010725	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668010726	non-specific DNA binding site [nucleotide binding]; other site
1097668010727	salt bridge; other site
1097668010728	sequence-specific DNA binding site [nucleotide binding]; other site
1097668010729	Cupin domain; Region: Cupin_2; pfam07883
1097668010730	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1097668010731	agmatinase; Region: agmatinase; TIGR01230
1097668010732	oligomer interface [polypeptide binding]; other site
1097668010733	putative active site [active]
1097668010734	Mn binding site [ion binding]; other site
1097668010735	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1097668010736	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1097668010737	potential catalytic triad [active]
1097668010738	conserved cys residue [active]
1097668010739	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010740	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010741	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668010742	dimerization interface [polypeptide binding]; other site
1097668010743	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668010744	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668010745	NAD(P) binding site [chemical binding]; other site
1097668010746	active site
1097668010747	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010748	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010749	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668010750	putative effector binding pocket; other site
1097668010751	dimerization interface [polypeptide binding]; other site
1097668010752	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1097668010753	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668010754	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1097668010755	dimerization interface [polypeptide binding]; other site
1097668010756	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668010757	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668010758	metal binding site [ion binding]; metal-binding site
1097668010759	active site
1097668010760	I-site; other site
1097668010761	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1097668010762	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668010763	Phasin protein; Region: Phasin_2; pfam09361
1097668010764	Integrase core domain; Region: rve_2; pfam13333
1097668010765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668010766	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668010767	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668010768	putative transposase OrfB; Reviewed; Region: PHA02517
1097668010769	HTH-like domain; Region: HTH_21; pfam13276
1097668010770	Integrase core domain; Region: rve; pfam00665
1097668010771	Integrase core domain; Region: rve_2; pfam13333
1097668010772	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668010773	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097668010774	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1097668010775	Na binding site [ion binding]; other site
1097668010776	putative amidase; Provisional; Region: PRK06169
1097668010777	Amidase; Region: Amidase; pfam01425
1097668010778	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1097668010779	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668010780	dimer interface [polypeptide binding]; other site
1097668010781	phosphorylation site [posttranslational modification]
1097668010782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668010783	ATP binding site [chemical binding]; other site
1097668010784	Mg2+ binding site [ion binding]; other site
1097668010785	G-X-G motif; other site
1097668010786	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668010787	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668010788	active site
1097668010789	phosphorylation site [posttranslational modification]
1097668010790	intermolecular recognition site; other site
1097668010791	dimerization interface [polypeptide binding]; other site
1097668010792	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097668010793	Na binding site [ion binding]; other site
1097668010794	acetylornithine deacetylase; Provisional; Region: PRK07522
1097668010795	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1097668010796	metal binding site [ion binding]; metal-binding site
1097668010797	putative dimer interface [polypeptide binding]; other site
1097668010798	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
1097668010799	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1097668010800	homotrimer interaction site [polypeptide binding]; other site
1097668010801	putative active site [active]
1097668010802	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1097668010803	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668010804	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010805	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010806	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1097668010807	putative substrate binding pocket [chemical binding]; other site
1097668010808	dimerization interface [polypeptide binding]; other site
1097668010809	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668010810	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668010811	[2Fe-2S] cluster binding site [ion binding]; other site
1097668010812	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885
1097668010813	putative alpha subunit interface [polypeptide binding]; other site
1097668010814	putative active site [active]
1097668010815	putative substrate binding site [chemical binding]; other site
1097668010816	Fe binding site [ion binding]; other site
1097668010817	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668010818	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1097668010819	Walker A/P-loop; other site
1097668010820	ATP binding site [chemical binding]; other site
1097668010821	Q-loop/lid; other site
1097668010822	ABC transporter signature motif; other site
1097668010823	Walker B; other site
1097668010824	D-loop; other site
1097668010825	H-loop/switch region; other site
1097668010826	TOBE domain; Region: TOBE_2; pfam08402
1097668010827	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668010828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010829	dimer interface [polypeptide binding]; other site
1097668010830	conserved gate region; other site
1097668010831	putative PBP binding loops; other site
1097668010832	ABC-ATPase subunit interface; other site
1097668010833	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668010834	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668010835	conserved gate region; other site
1097668010836	dimer interface [polypeptide binding]; other site
1097668010837	putative PBP binding loops; other site
1097668010838	ABC-ATPase subunit interface; other site
1097668010839	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010841	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1097668010842	putative substrate binding pocket [chemical binding]; other site
1097668010843	dimerization interface [polypeptide binding]; other site
1097668010844	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668010845	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668010846	[2Fe-2S] cluster binding site [ion binding]; other site
1097668010847	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668010848	hydrophobic ligand binding site; other site
1097668010849	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668010850	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668010851	FMN-binding pocket [chemical binding]; other site
1097668010852	flavin binding motif; other site
1097668010853	phosphate binding motif [ion binding]; other site
1097668010854	beta-alpha-beta structure motif; other site
1097668010855	NAD binding pocket [chemical binding]; other site
1097668010856	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668010857	catalytic loop [active]
1097668010858	iron binding site [ion binding]; other site
1097668010859	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1097668010860	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1097668010861	aspartate aminotransferase; Provisional; Region: PRK06107
1097668010862	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097668010863	conserved cys residue [active]
1097668010864	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668010865	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668010866	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668010867	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097668010868	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1097668010869	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1097668010870	active site
1097668010871	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668010872	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1097668010873	active site
1097668010874	dimer interface [polypeptide binding]; other site
1097668010875	metal binding site [ion binding]; metal-binding site
1097668010876	SnoaL-like domain; Region: SnoaL_4; pfam13577
1097668010877	SnoaL-like domain; Region: SnoaL_3; pfam13474
1097668010878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668010879	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668010880	putative substrate translocation pore; other site
1097668010881	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1097668010882	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668010883	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668010884	shikimate binding site; other site
1097668010885	NAD(P) binding site [chemical binding]; other site
1097668010886	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668010887	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668010888	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668010889	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668010890	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668010891	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010892	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1097668010893	putative dimerization interface [polypeptide binding]; other site
1097668010894	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1097668010895	Citrate transporter; Region: CitMHS; pfam03600
1097668010896	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1097668010897	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668010898	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668010899	dimerization interface [polypeptide binding]; other site
1097668010900	ligand binding site [chemical binding]; other site
1097668010901	aldolase II superfamily protein; Provisional; Region: PRK07044
1097668010902	intersubunit interface [polypeptide binding]; other site
1097668010903	active site
1097668010904	Zn2+ binding site [ion binding]; other site
1097668010905	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668010906	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668010907	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668010908	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668010909	Ligand binding site [chemical binding]; other site
1097668010910	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668010911	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668010912	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668010913	Walker A/P-loop; other site
1097668010914	ATP binding site [chemical binding]; other site
1097668010915	Q-loop/lid; other site
1097668010916	ABC transporter signature motif; other site
1097668010917	Walker B; other site
1097668010918	D-loop; other site
1097668010919	H-loop/switch region; other site
1097668010920	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668010921	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668010922	Walker A/P-loop; other site
1097668010923	ATP binding site [chemical binding]; other site
1097668010924	Q-loop/lid; other site
1097668010925	ABC transporter signature motif; other site
1097668010926	Walker B; other site
1097668010927	D-loop; other site
1097668010928	H-loop/switch region; other site
1097668010929	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668010930	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668010931	TM-ABC transporter signature motif; other site
1097668010932	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668010933	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668010934	TM-ABC transporter signature motif; other site
1097668010935	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1097668010936	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097668010937	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097668010938	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1097668010939	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1097668010940	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668010941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668010942	active site
1097668010943	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668010944	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668010945	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1097668010946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668010947	NAD(P) binding site [chemical binding]; other site
1097668010948	active site
1097668010949	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668010950	classical (c) SDRs; Region: SDR_c; cd05233
1097668010951	NAD(P) binding site [chemical binding]; other site
1097668010952	active site
1097668010953	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668010954	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668010955	DNA-binding site [nucleotide binding]; DNA binding site
1097668010956	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668010957	ornithine cyclodeaminase; Validated; Region: PRK07340
1097668010958	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1097668010959	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1097668010960	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1097668010961	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668010962	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668010963	dimerization interface [polypeptide binding]; other site
1097668010964	ligand binding site [chemical binding]; other site
1097668010965	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1097668010966	allantoate amidohydrolase; Reviewed; Region: PRK12893
1097668010967	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668010968	active site
1097668010969	metal binding site [ion binding]; metal-binding site
1097668010970	dimer interface [polypeptide binding]; other site
1097668010971	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668010972	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1097668010973	aspartate aminotransferase; Provisional; Region: PRK06225
1097668010974	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668010975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668010976	homodimer interface [polypeptide binding]; other site
1097668010977	catalytic residue [active]
1097668010978	short chain dehydrogenase; Provisional; Region: PRK06125
1097668010979	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668010980	NAD(P) binding site [chemical binding]; other site
1097668010981	active site
1097668010982	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1097668010983	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668010984	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668010985	trimer interface [polypeptide binding]; other site
1097668010986	eyelet of channel; other site
1097668010987	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668010988	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668010989	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668010990	dimerization interface [polypeptide binding]; other site
1097668010991	substrate binding pocket [chemical binding]; other site
1097668010992	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668010993	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668010994	FMN-binding pocket [chemical binding]; other site
1097668010995	flavin binding motif; other site
1097668010996	phosphate binding motif [ion binding]; other site
1097668010997	beta-alpha-beta structure motif; other site
1097668010998	NAD binding pocket [chemical binding]; other site
1097668010999	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668011000	catalytic loop [active]
1097668011001	iron binding site [ion binding]; other site
1097668011002	benzoate transport; Region: 2A0115; TIGR00895
1097668011003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011004	putative substrate translocation pore; other site
1097668011005	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1097668011006	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668011007	iron-sulfur cluster [ion binding]; other site
1097668011008	[2Fe-2S] cluster binding site [ion binding]; other site
1097668011009	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1097668011010	alpha subunit interface [polypeptide binding]; other site
1097668011011	active site
1097668011012	substrate binding site [chemical binding]; other site
1097668011013	Fe binding site [ion binding]; other site
1097668011014	Helix-turn-helix domain; Region: HTH_17; pfam12728
1097668011015	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
1097668011016	dimer interface [polypeptide binding]; other site
1097668011017	active site
1097668011018	coenzyme A binding site [chemical binding]; other site
1097668011019	citrylCoA binding site [chemical binding]; other site
1097668011020	Citrate synthase; Region: Citrate_synt; pfam00285
1097668011021	oxalacetate/citrate binding site [chemical binding]; other site
1097668011022	catalytic triad [active]
1097668011023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011024	benzoate transport; Region: 2A0115; TIGR00895
1097668011025	putative substrate translocation pore; other site
1097668011026	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
1097668011027	intersubunit interface [polypeptide binding]; other site
1097668011028	active site
1097668011029	Zn2+ binding site [ion binding]; other site
1097668011030	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668011031	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668011032	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1097668011033	transcriptional regulator NanR; Provisional; Region: PRK03837
1097668011034	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011035	DNA-binding site [nucleotide binding]; DNA binding site
1097668011036	FCD domain; Region: FCD; pfam07729
1097668011037	betaine aldehyde dehydrogenase; Region: PLN02467
1097668011038	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
1097668011039	NAD(P) binding site [chemical binding]; other site
1097668011040	catalytic residues [active]
1097668011041	catalytic residues [active]
1097668011042	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668011043	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668011044	inhibitor site; inhibition site
1097668011045	active site
1097668011046	dimer interface [polypeptide binding]; other site
1097668011047	catalytic residue [active]
1097668011048	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097668011049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011050	DNA-binding site [nucleotide binding]; DNA binding site
1097668011051	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668011052	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668011053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668011054	homodimer interface [polypeptide binding]; other site
1097668011055	catalytic residue [active]
1097668011056	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1097668011057	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1097668011058	MOFRL family; Region: MOFRL; pfam05161
1097668011059	enolase; Provisional; Region: eno; PRK00077
1097668011060	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1097668011061	dimer interface [polypeptide binding]; other site
1097668011062	metal binding site [ion binding]; metal-binding site
1097668011063	substrate binding pocket [chemical binding]; other site
1097668011064	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1097668011065	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1097668011066	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668011067	Proline racemase; Region: Pro_racemase; pfam05544
1097668011068	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668011069	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668011070	NAD(P) binding site [chemical binding]; other site
1097668011071	shikimate binding site; other site
1097668011072	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1097668011073	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668011074	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1097668011075	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668011076	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668011077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011078	dimer interface [polypeptide binding]; other site
1097668011079	conserved gate region; other site
1097668011080	putative PBP binding loops; other site
1097668011081	ABC-ATPase subunit interface; other site
1097668011082	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668011083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011084	dimer interface [polypeptide binding]; other site
1097668011085	conserved gate region; other site
1097668011086	putative PBP binding loops; other site
1097668011087	ABC-ATPase subunit interface; other site
1097668011088	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668011089	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668011090	Walker A/P-loop; other site
1097668011091	ATP binding site [chemical binding]; other site
1097668011092	Q-loop/lid; other site
1097668011093	ABC transporter signature motif; other site
1097668011094	Walker B; other site
1097668011095	D-loop; other site
1097668011096	H-loop/switch region; other site
1097668011097	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668011098	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668011099	substrate binding pocket [chemical binding]; other site
1097668011100	membrane-bound complex binding site; other site
1097668011101	hinge residues; other site
1097668011102	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1097668011103	homotrimer interaction site [polypeptide binding]; other site
1097668011104	putative active site [active]
1097668011105	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1097668011106	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1097668011107	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1097668011108	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097668011109	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097668011110	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1097668011111	classical (c) SDRs; Region: SDR_c; cd05233
1097668011112	NAD(P) binding site [chemical binding]; other site
1097668011113	active site
1097668011114	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668011115	active site 1 [active]
1097668011116	dimer interface [polypeptide binding]; other site
1097668011117	hexamer interface [polypeptide binding]; other site
1097668011118	active site 2 [active]
1097668011119	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668011120	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011121	DNA-binding site [nucleotide binding]; DNA binding site
1097668011122	FCD domain; Region: FCD; pfam07729
1097668011123	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668011124	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011125	DNA-binding site [nucleotide binding]; DNA binding site
1097668011126	FCD domain; Region: FCD; pfam07729
1097668011127	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668011128	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668011129	dimerization interface [polypeptide binding]; other site
1097668011130	ligand binding site [chemical binding]; other site
1097668011131	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1097668011132	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668011133	N-terminal plug; other site
1097668011134	ligand-binding site [chemical binding]; other site
1097668011135	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1097668011136	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668011137	putative ligand binding site [chemical binding]; other site
1097668011138	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1097668011139	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668011140	TM-ABC transporter signature motif; other site
1097668011141	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668011142	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668011143	TM-ABC transporter signature motif; other site
1097668011144	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668011145	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668011146	Walker A/P-loop; other site
1097668011147	ATP binding site [chemical binding]; other site
1097668011148	Q-loop/lid; other site
1097668011149	ABC transporter signature motif; other site
1097668011150	Walker B; other site
1097668011151	D-loop; other site
1097668011152	H-loop/switch region; other site
1097668011153	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668011154	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
1097668011155	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668011156	putative ligand binding site [chemical binding]; other site
1097668011157	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1097668011158	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1097668011159	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1097668011160	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097668011161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011162	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668011163	putative substrate translocation pore; other site
1097668011164	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011165	DNA-binding site [nucleotide binding]; DNA binding site
1097668011166	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1097668011167	FCD domain; Region: FCD; pfam07729
1097668011168	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011169	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011170	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011171	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011172	thiolase; Provisional; Region: PRK06158
1097668011173	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1097668011174	active site
1097668011175	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
1097668011176	DUF35 OB-fold domain; Region: DUF35; pfam01796
1097668011177	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1097668011178	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1097668011179	DAK2 domain; Region: Dak2; pfam02734
1097668011180	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668011181	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668011182	NAD(P) binding site [chemical binding]; other site
1097668011183	catalytic residues [active]
1097668011184	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668011185	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011186	DNA-binding site [nucleotide binding]; DNA binding site
1097668011187	FCD domain; Region: FCD; pfam07729
1097668011188	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668011189	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668011190	active site
1097668011191	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668011192	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011193	putative substrate translocation pore; other site
1097668011194	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1097668011195	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1097668011196	Strictosidine synthase; Region: Str_synth; pfam03088
1097668011197	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668011198	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668011199	Walker A/P-loop; other site
1097668011200	ATP binding site [chemical binding]; other site
1097668011201	Q-loop/lid; other site
1097668011202	ABC transporter signature motif; other site
1097668011203	Walker B; other site
1097668011204	D-loop; other site
1097668011205	H-loop/switch region; other site
1097668011206	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668011207	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668011208	Walker A/P-loop; other site
1097668011209	ATP binding site [chemical binding]; other site
1097668011210	Q-loop/lid; other site
1097668011211	ABC transporter signature motif; other site
1097668011212	Walker B; other site
1097668011213	D-loop; other site
1097668011214	H-loop/switch region; other site
1097668011215	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668011216	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668011217	TM-ABC transporter signature motif; other site
1097668011218	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668011219	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668011220	TM-ABC transporter signature motif; other site
1097668011221	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668011222	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668011223	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668011224	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668011225	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668011226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011227	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668011228	putative substrate translocation pore; other site
1097668011229	short chain dehydrogenase; Provisional; Region: PRK06123
1097668011230	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668011231	NAD(P) binding site [chemical binding]; other site
1097668011232	active site
1097668011233	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668011234	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011235	DNA-binding site [nucleotide binding]; DNA binding site
1097668011236	FCD domain; Region: FCD; pfam07729
1097668011237	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
1097668011238	DUF35 OB-fold domain; Region: DUF35; pfam01796
1097668011239	lipid-transfer protein; Provisional; Region: PRK06059
1097668011240	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1097668011241	active site
1097668011242	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011243	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011244	putative CoA-transferase; Provisional; Region: PRK11430
1097668011245	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011246	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
1097668011247	Protein of unknown function (DUF2000); Region: DUF2000; cl02074
1097668011248	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668011249	trimer interface [polypeptide binding]; other site
1097668011250	oxyanion hole (OAH) forming residues; other site
1097668011251	drug efflux system protein MdtG; Provisional; Region: PRK09874
1097668011252	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011253	putative substrate translocation pore; other site
1097668011254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011255	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011256	putative substrate translocation pore; other site
1097668011257	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1097668011258	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668011259	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668011260	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668011261	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668011262	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668011263	active site
1097668011264	catalytic tetrad [active]
1097668011265	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097668011266	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1097668011267	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668011268	BON domain; Region: BON; pfam04972
1097668011269	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668011270	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668011271	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1097668011272	substrate binding site [chemical binding]; other site
1097668011273	activation loop (A-loop); other site
1097668011274	AAA ATPase domain; Region: AAA_16; pfam13191
1097668011275	Predicted ATPase [General function prediction only]; Region: COG3899
1097668011276	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097668011277	GAF domain; Region: GAF; pfam01590
1097668011278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668011279	PAS fold; Region: PAS_3; pfam08447
1097668011280	putative active site [active]
1097668011281	heme pocket [chemical binding]; other site
1097668011282	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668011283	dimer interface [polypeptide binding]; other site
1097668011284	phosphorylation site [posttranslational modification]
1097668011285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668011286	ATP binding site [chemical binding]; other site
1097668011287	G-X-G motif; other site
1097668011288	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668011289	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668011290	substrate binding site [chemical binding]; other site
1097668011291	oxyanion hole (OAH) forming residues; other site
1097668011292	trimer interface [polypeptide binding]; other site
1097668011293	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1097668011294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668011295	active site
1097668011296	phosphorylation site [posttranslational modification]
1097668011297	intermolecular recognition site; other site
1097668011298	dimerization interface [polypeptide binding]; other site
1097668011299	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668011300	DNA binding residues [nucleotide binding]
1097668011301	dimerization interface [polypeptide binding]; other site
1097668011302	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1097668011303	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668011304	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668011305	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1097668011306	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1097668011307	active site
1097668011308	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668011309	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668011310	active site
1097668011311	Predicted transcriptional regulator [Transcription]; Region: COG2345
1097668011312	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668011313	putative DNA binding site [nucleotide binding]; other site
1097668011314	putative Zn2+ binding site [ion binding]; other site
1097668011315	V4R domain; Region: V4R; cl15268
1097668011316	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668011317	MarR family; Region: MarR; pfam01047
1097668011318	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1097668011319	NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231
1097668011320	putative NADP binding site [chemical binding]; other site
1097668011321	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
1097668011322	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668011323	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668011324	conserved cys residue [active]
1097668011325	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1097668011326	zinc binding site [ion binding]; other site
1097668011327	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668011328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668011329	Q-loop/lid; other site
1097668011330	ABC transporter signature motif; other site
1097668011331	Walker B; other site
1097668011332	D-loop; other site
1097668011333	H-loop/switch region; other site
1097668011334	TOBE domain; Region: TOBE_2; pfam08402
1097668011335	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668011336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011337	dimer interface [polypeptide binding]; other site
1097668011338	conserved gate region; other site
1097668011339	putative PBP binding loops; other site
1097668011340	ABC-ATPase subunit interface; other site
1097668011341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011342	putative PBP binding loops; other site
1097668011343	dimer interface [polypeptide binding]; other site
1097668011344	ABC-ATPase subunit interface; other site
1097668011345	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668011346	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1097668011347	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1097668011348	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1097668011349	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1097668011350	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1097668011351	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1097668011352	PhoU domain; Region: PhoU; pfam01895
1097668011353	OsmC-like protein; Region: OsmC; cl00767
1097668011354	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668011355	MarR family; Region: MarR; pfam01047
1097668011356	MarR family; Region: MarR_2; cl17246
1097668011357	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668011358	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668011359	substrate binding pocket [chemical binding]; other site
1097668011360	membrane-bound complex binding site; other site
1097668011361	hinge residues; other site
1097668011362	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668011363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011364	dimer interface [polypeptide binding]; other site
1097668011365	conserved gate region; other site
1097668011366	ABC-ATPase subunit interface; other site
1097668011367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011368	dimer interface [polypeptide binding]; other site
1097668011369	conserved gate region; other site
1097668011370	putative PBP binding loops; other site
1097668011371	ABC-ATPase subunit interface; other site
1097668011372	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668011373	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668011374	Walker A/P-loop; other site
1097668011375	ATP binding site [chemical binding]; other site
1097668011376	Q-loop/lid; other site
1097668011377	ABC transporter signature motif; other site
1097668011378	Walker B; other site
1097668011379	D-loop; other site
1097668011380	H-loop/switch region; other site
1097668011381	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668011382	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1097668011383	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668011384	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668011385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668011386	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668011387	substrate binding pocket [chemical binding]; other site
1097668011388	dimerization interface [polypeptide binding]; other site
1097668011389	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1097668011390	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668011391	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668011392	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1097668011393	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1097668011394	active site
1097668011395	catalytic site [active]
1097668011396	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011397	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011398	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1097668011399	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668011400	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668011401	shikimate binding site; other site
1097668011402	NAD(P) binding site [chemical binding]; other site
1097668011403	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1097668011404	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1097668011405	trimer interface [polypeptide binding]; other site
1097668011406	active site
1097668011407	dimer interface [polypeptide binding]; other site
1097668011408	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1097668011409	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668011410	catalytic residues [active]
1097668011411	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1097668011412	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668011413	catalytic residues [active]
1097668011414	transcriptional activator TtdR; Provisional; Region: PRK09801
1097668011415	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668011416	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1097668011417	putative effector binding pocket; other site
1097668011418	putative dimerization interface [polypeptide binding]; other site
1097668011419	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668011420	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326
1097668011421	putative active site pocket [active]
1097668011422	metal binding site [ion binding]; metal-binding site
1097668011423	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097668011424	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1097668011425	malic enzyme; Reviewed; Region: PRK12862
1097668011426	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1097668011427	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1097668011428	putative NAD(P) binding site [chemical binding]; other site
1097668011429	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1097668011430	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668011431	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668011432	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668011433	dimerization interface [polypeptide binding]; other site
1097668011434	substrate binding pocket [chemical binding]; other site
1097668011435	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1097668011436	TPP-binding site [chemical binding]; other site
1097668011437	dimer interface [polypeptide binding]; other site
1097668011438	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1097668011439	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097668011440	PYR/PP interface [polypeptide binding]; other site
1097668011441	dimer interface [polypeptide binding]; other site
1097668011442	TPP binding site [chemical binding]; other site
1097668011443	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668011444	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668011445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668011446	NAD(P) binding site [chemical binding]; other site
1097668011447	active site
1097668011448	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1097668011449	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1097668011450	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1097668011451	DctM-like transporters; Region: DctM; pfam06808
1097668011452	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1097668011453	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1097668011454	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1097668011455	TPP-binding site [chemical binding]; other site
1097668011456	dimer interface [polypeptide binding]; other site
1097668011457	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097668011458	PYR/PP interface [polypeptide binding]; other site
1097668011459	dimer interface [polypeptide binding]; other site
1097668011460	TPP binding site [chemical binding]; other site
1097668011461	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668011462	glycerate dehydrogenase; Provisional; Region: PRK06932
1097668011463	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1097668011464	putative ligand binding site [chemical binding]; other site
1097668011465	putative NAD binding site [chemical binding]; other site
1097668011466	catalytic site [active]
1097668011467	HdeA/HdeB family; Region: HdeA; cl05752
1097668011468	Cupin domain; Region: Cupin_2; pfam07883
1097668011469	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668011470	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668011471	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668011472	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668011473	Ligand binding site [chemical binding]; other site
1097668011474	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668011475	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668011476	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668011477	substrate binding site [chemical binding]; other site
1097668011478	oxyanion hole (OAH) forming residues; other site
1097668011479	trimer interface [polypeptide binding]; other site
1097668011480	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097668011481	active site
1097668011482	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
1097668011483	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1097668011484	active site
1097668011485	citrylCoA binding site [chemical binding]; other site
1097668011486	oxalacetate binding site [chemical binding]; other site
1097668011487	coenzyme A binding site [chemical binding]; other site
1097668011488	catalytic triad [active]
1097668011489	acyl-CoA synthetase; Validated; Region: PRK06164
1097668011490	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668011491	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668011492	acyl-activating enzyme (AAE) consensus motif; other site
1097668011493	acyl-activating enzyme (AAE) consensus motif; other site
1097668011494	AMP binding site [chemical binding]; other site
1097668011495	active site
1097668011496	CoA binding site [chemical binding]; other site
1097668011497	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1097668011498	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668011499	active site
1097668011500	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1097668011501	benzoate transport; Region: 2A0115; TIGR00895
1097668011502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011503	putative substrate translocation pore; other site
1097668011504	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1097668011505	homotrimer interaction site [polypeptide binding]; other site
1097668011506	putative active site [active]
1097668011507	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668011508	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668011509	DNA binding site [nucleotide binding]
1097668011510	domain linker motif; other site
1097668011511	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1097668011512	ligand binding site [chemical binding]; other site
1097668011513	CAAX protease self-immunity; Region: Abi; pfam02517
1097668011514	hypothetical protein; Provisional; Region: PRK07524
1097668011515	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668011516	PYR/PP interface [polypeptide binding]; other site
1097668011517	dimer interface [polypeptide binding]; other site
1097668011518	TPP binding site [chemical binding]; other site
1097668011519	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668011520	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1097668011521	TPP-binding site [chemical binding]; other site
1097668011522	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668011523	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
1097668011524	NAD(P) binding site [chemical binding]; other site
1097668011525	catalytic residues [active]
1097668011526	catalytic residues [active]
1097668011527	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1097668011528	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668011529	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1097668011530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011531	dimer interface [polypeptide binding]; other site
1097668011532	conserved gate region; other site
1097668011533	putative PBP binding loops; other site
1097668011534	ABC-ATPase subunit interface; other site
1097668011535	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668011536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011537	dimer interface [polypeptide binding]; other site
1097668011538	conserved gate region; other site
1097668011539	putative PBP binding loops; other site
1097668011540	ABC-ATPase subunit interface; other site
1097668011541	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668011542	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668011543	Walker A/P-loop; other site
1097668011544	ATP binding site [chemical binding]; other site
1097668011545	Q-loop/lid; other site
1097668011546	ABC transporter signature motif; other site
1097668011547	Walker B; other site
1097668011548	D-loop; other site
1097668011549	H-loop/switch region; other site
1097668011550	TOBE domain; Region: TOBE; pfam03459
1097668011551	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668011552	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668011553	substrate binding pocket [chemical binding]; other site
1097668011554	membrane-bound complex binding site; other site
1097668011555	hinge residues; other site
1097668011556	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011557	dimer interface [polypeptide binding]; other site
1097668011558	conserved gate region; other site
1097668011559	putative PBP binding loops; other site
1097668011560	ABC-ATPase subunit interface; other site
1097668011561	amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726
1097668011562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011563	putative PBP binding loops; other site
1097668011564	dimer interface [polypeptide binding]; other site
1097668011565	ABC-ATPase subunit interface; other site
1097668011566	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668011567	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668011568	Walker A/P-loop; other site
1097668011569	ATP binding site [chemical binding]; other site
1097668011570	Q-loop/lid; other site
1097668011571	ABC transporter signature motif; other site
1097668011572	Walker B; other site
1097668011573	D-loop; other site
1097668011574	H-loop/switch region; other site
1097668011575	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668011576	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668011577	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668011578	substrate binding pocket [chemical binding]; other site
1097668011579	dimerization interface [polypeptide binding]; other site
1097668011580	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668011581	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668011582	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668011583	putative effector binding pocket; other site
1097668011584	dimerization interface [polypeptide binding]; other site
1097668011585	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097668011586	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1097668011587	active site
1097668011588	FMN binding site [chemical binding]; other site
1097668011589	substrate binding site [chemical binding]; other site
1097668011590	putative catalytic residue [active]
1097668011591	Cupin; Region: Cupin_6; pfam12852
1097668011592	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668011593	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668011594	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668011595	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1097668011596	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1097668011597	mercuric reductase; Validated; Region: PRK06370
1097668011598	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668011599	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668011600	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668011601	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668011602	Walker A/P-loop; other site
1097668011603	ATP binding site [chemical binding]; other site
1097668011604	Q-loop/lid; other site
1097668011605	ABC transporter signature motif; other site
1097668011606	Walker B; other site
1097668011607	D-loop; other site
1097668011608	H-loop/switch region; other site
1097668011609	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668011610	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668011611	Walker A/P-loop; other site
1097668011612	ATP binding site [chemical binding]; other site
1097668011613	Q-loop/lid; other site
1097668011614	ABC transporter signature motif; other site
1097668011615	Walker B; other site
1097668011616	D-loop; other site
1097668011617	H-loop/switch region; other site
1097668011618	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668011619	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668011620	TM-ABC transporter signature motif; other site
1097668011621	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668011622	TM-ABC transporter signature motif; other site
1097668011623	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668011624	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1097668011625	ligand binding site [chemical binding]; other site
1097668011626	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668011627	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1097668011628	active site pocket [active]
1097668011629	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668011630	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1097668011631	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668011632	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668011633	active site 1 [active]
1097668011634	dimer interface [polypeptide binding]; other site
1097668011635	hexamer interface [polypeptide binding]; other site
1097668011636	active site 2 [active]
1097668011637	thiamine pyrophosphate protein; Validated; Region: PRK08199
1097668011638	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668011639	PYR/PP interface [polypeptide binding]; other site
1097668011640	dimer interface [polypeptide binding]; other site
1097668011641	TPP binding site [chemical binding]; other site
1097668011642	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668011643	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1097668011644	TPP-binding site [chemical binding]; other site
1097668011645	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668011646	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668011647	NAD(P) binding site [chemical binding]; other site
1097668011648	catalytic residues [active]
1097668011649	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011650	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011651	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1097668011652	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668011653	active site
1097668011654	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668011655	active site
1097668011656	enoyl-CoA hydratase; Provisional; Region: PRK09245
1097668011657	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668011658	substrate binding site [chemical binding]; other site
1097668011659	oxyanion hole (OAH) forming residues; other site
1097668011660	trimer interface [polypeptide binding]; other site
1097668011661	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668011662	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668011663	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668011664	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668011665	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1097668011666	active site pocket [active]
1097668011667	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668011668	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668011669	trimer interface [polypeptide binding]; other site
1097668011670	eyelet of channel; other site
1097668011671	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097668011672	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011673	DNA-binding site [nucleotide binding]; DNA binding site
1097668011674	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1097668011675	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668011676	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340
1097668011677	putative ligand binding site [chemical binding]; other site
1097668011678	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668011679	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668011680	TM-ABC transporter signature motif; other site
1097668011681	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668011682	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668011683	TM-ABC transporter signature motif; other site
1097668011684	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668011685	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668011686	Walker A/P-loop; other site
1097668011687	ATP binding site [chemical binding]; other site
1097668011688	Q-loop/lid; other site
1097668011689	ABC transporter signature motif; other site
1097668011690	Walker B; other site
1097668011691	D-loop; other site
1097668011692	H-loop/switch region; other site
1097668011693	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668011694	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668011695	Walker A/P-loop; other site
1097668011696	ATP binding site [chemical binding]; other site
1097668011697	Q-loop/lid; other site
1097668011698	ABC transporter signature motif; other site
1097668011699	Walker B; other site
1097668011700	D-loop; other site
1097668011701	H-loop/switch region; other site
1097668011702	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1097668011703	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1097668011704	substrate binding site [chemical binding]; other site
1097668011705	ligand binding site [chemical binding]; other site
1097668011706	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
1097668011707	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1097668011708	substrate binding site [chemical binding]; other site
1097668011709	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1097668011710	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1097668011711	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1097668011712	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097668011713	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097668011714	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668011715	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1097668011716	catalytic triad [active]
1097668011717	conserved cis-peptide bond; other site
1097668011718	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1097668011719	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668011720	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668011721	tetramer interface [polypeptide binding]; other site
1097668011722	active site
1097668011723	Mg2+/Mn2+ binding site [ion binding]; other site
1097668011724	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668011725	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
1097668011726	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668011727	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668011728	Ligand binding site [chemical binding]; other site
1097668011729	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668011730	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668011731	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668011732	trimer interface [polypeptide binding]; other site
1097668011733	eyelet of channel; other site
1097668011734	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668011735	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1097668011736	catalytic triad [active]
1097668011737	conserved cis-peptide bond; other site
1097668011738	phenylhydantoinase; Validated; Region: PRK08323
1097668011739	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668011740	active site
1097668011741	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1097668011742	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668011743	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1097668011744	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1097668011745	precorrin 3B synthase CobZ; Region: CobZ_N-term; TIGR02485
1097668011746	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1097668011747	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
1097668011748	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668011749	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668011750	Walker A/P-loop; other site
1097668011751	ATP binding site [chemical binding]; other site
1097668011752	Q-loop/lid; other site
1097668011753	ABC transporter signature motif; other site
1097668011754	Walker B; other site
1097668011755	D-loop; other site
1097668011756	H-loop/switch region; other site
1097668011757	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668011758	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668011759	Walker A/P-loop; other site
1097668011760	ATP binding site [chemical binding]; other site
1097668011761	Q-loop/lid; other site
1097668011762	ABC transporter signature motif; other site
1097668011763	Walker B; other site
1097668011764	D-loop; other site
1097668011765	H-loop/switch region; other site
1097668011766	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668011767	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668011768	TM-ABC transporter signature motif; other site
1097668011769	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668011770	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668011771	TM-ABC transporter signature motif; other site
1097668011772	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668011773	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1097668011774	ligand binding site [chemical binding]; other site
1097668011775	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668011776	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668011777	putative DNA binding site [nucleotide binding]; other site
1097668011778	putative Zn2+ binding site [ion binding]; other site
1097668011779	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668011780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011781	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668011782	putative substrate translocation pore; other site
1097668011783	FAD binding domain; Region: FAD_binding_3; pfam01494
1097668011784	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668011785	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668011786	short chain dehydrogenase; Provisional; Region: PRK06125
1097668011787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668011788	NAD(P) binding site [chemical binding]; other site
1097668011789	active site
1097668011790	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1097668011791	benzoate transport; Region: 2A0115; TIGR00895
1097668011792	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011793	putative substrate translocation pore; other site
1097668011794	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668011795	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668011796	trimer interface [polypeptide binding]; other site
1097668011797	eyelet of channel; other site
1097668011798	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011799	DNA-binding site [nucleotide binding]; DNA binding site
1097668011800	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668011801	FCD domain; Region: FCD; pfam07729
1097668011802	Amidase; Region: Amidase; cl11426
1097668011803	Amidase; Region: Amidase; cl11426
1097668011804	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011805	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011806	enoyl-CoA hydratase; Provisional; Region: PRK06127
1097668011807	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668011808	substrate binding site [chemical binding]; other site
1097668011809	oxyanion hole (OAH) forming residues; other site
1097668011810	trimer interface [polypeptide binding]; other site
1097668011811	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668011812	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668011813	substrate binding pocket [chemical binding]; other site
1097668011814	membrane-bound complex binding site; other site
1097668011815	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668011816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011817	dimer interface [polypeptide binding]; other site
1097668011818	conserved gate region; other site
1097668011819	putative PBP binding loops; other site
1097668011820	ABC-ATPase subunit interface; other site
1097668011821	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668011822	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668011823	Walker A/P-loop; other site
1097668011824	ATP binding site [chemical binding]; other site
1097668011825	Q-loop/lid; other site
1097668011826	ABC transporter signature motif; other site
1097668011827	Walker B; other site
1097668011828	D-loop; other site
1097668011829	H-loop/switch region; other site
1097668011830	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
1097668011831	putative active site [active]
1097668011832	putative catalytic site [active]
1097668011833	Uncharacterized conserved protein [Function unknown]; Region: COG3777
1097668011834	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668011835	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668011836	active site 2 [active]
1097668011837	active site 1 [active]
1097668011838	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1097668011839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668011840	Walker A motif; other site
1097668011841	ATP binding site [chemical binding]; other site
1097668011842	Walker B motif; other site
1097668011843	arginine finger; other site
1097668011844	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668011845	Predicted membrane protein [Function unknown]; Region: COG4655
1097668011846	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1097668011847	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
1097668011848	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
1097668011849	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1097668011850	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1097668011851	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668011852	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1097668011853	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1097668011854	ATP binding site [chemical binding]; other site
1097668011855	Walker A motif; other site
1097668011856	hexamer interface [polypeptide binding]; other site
1097668011857	Walker B motif; other site
1097668011858	AAA domain; Region: AAA_31; pfam13614
1097668011859	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1097668011860	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1097668011861	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1097668011862	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1097668011863	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1097668011864	TadE-like protein; Region: TadE; pfam07811
1097668011865	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1097668011866	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
1097668011867	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1097668011868	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1097668011869	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
1097668011870	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1097668011871	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097668011872	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
1097668011873	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1097668011874	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668011875	ATP binding site [chemical binding]; other site
1097668011876	putative Mg++ binding site [ion binding]; other site
1097668011877	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668011878	nucleotide binding region [chemical binding]; other site
1097668011879	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
1097668011880	ATP-binding site [chemical binding]; other site
1097668011881	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1097668011882	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1097668011883	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1097668011884	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1097668011885	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1097668011886	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
1097668011887	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668011888	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668011889	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1097668011890	Amidase; Region: Amidase; cl11426
1097668011891	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1097668011892	catalytic residues [active]
1097668011893	DinB superfamily; Region: DinB_2; pfam12867
1097668011894	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668011895	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1097668011896	catalytic triad [active]
1097668011897	conserved cis-peptide bond; other site
1097668011898	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668011899	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1097668011900	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097668011901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011902	dimer interface [polypeptide binding]; other site
1097668011903	conserved gate region; other site
1097668011904	putative PBP binding loops; other site
1097668011905	ABC-ATPase subunit interface; other site
1097668011906	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097668011907	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1097668011908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668011909	dimer interface [polypeptide binding]; other site
1097668011910	conserved gate region; other site
1097668011911	putative PBP binding loops; other site
1097668011912	ABC-ATPase subunit interface; other site
1097668011913	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1097668011914	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668011915	Walker A/P-loop; other site
1097668011916	ATP binding site [chemical binding]; other site
1097668011917	Q-loop/lid; other site
1097668011918	ABC transporter signature motif; other site
1097668011919	Walker B; other site
1097668011920	D-loop; other site
1097668011921	H-loop/switch region; other site
1097668011922	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668011923	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1097668011924	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668011925	Walker A/P-loop; other site
1097668011926	ATP binding site [chemical binding]; other site
1097668011927	Q-loop/lid; other site
1097668011928	ABC transporter signature motif; other site
1097668011929	Walker B; other site
1097668011930	D-loop; other site
1097668011931	H-loop/switch region; other site
1097668011932	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668011933	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1097668011934	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011935	DNA-binding site [nucleotide binding]; DNA binding site
1097668011936	FCD domain; Region: FCD; pfam07729
1097668011937	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668011938	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668011939	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
1097668011940	putative dimerization interface [polypeptide binding]; other site
1097668011941	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1097668011942	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011943	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011944	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668011945	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668011946	active site
1097668011947	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
1097668011948	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
1097668011949	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668011950	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668011951	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668011952	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668011953	Ligand binding site [chemical binding]; other site
1097668011954	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668011955	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1097668011956	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097668011957	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668011958	DNA-binding site [nucleotide binding]; DNA binding site
1097668011959	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1097668011960	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011961	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011962	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668011963	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668011964	active site
1097668011965	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
1097668011966	benzoate transport; Region: 2A0115; TIGR00895
1097668011967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011968	putative substrate translocation pore; other site
1097668011969	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011970	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1097668011971	putative active site [active]
1097668011972	putative catalytic site [active]
1097668011973	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1097668011974	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668011975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668011976	succinic semialdehyde dehydrogenase; Region: PLN02278
1097668011977	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668011978	tetramerization interface [polypeptide binding]; other site
1097668011979	NAD(P) binding site [chemical binding]; other site
1097668011980	catalytic residues [active]
1097668011981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668011982	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668011983	putative substrate translocation pore; other site
1097668011984	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668011985	enoyl-CoA hydratase; Provisional; Region: PRK09245
1097668011986	substrate binding site [chemical binding]; other site
1097668011987	oxyanion hole (OAH) forming residues; other site
1097668011988	trimer interface [polypeptide binding]; other site
1097668011989	enoyl-CoA hydratase; Provisional; Region: PRK05862
1097668011990	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668011991	substrate binding site [chemical binding]; other site
1097668011992	oxyanion hole (OAH) forming residues; other site
1097668011993	trimer interface [polypeptide binding]; other site
1097668011994	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668011995	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668011996	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668011997	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668011998	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668011999	dimerization interface [polypeptide binding]; other site
1097668012000	substrate binding pocket [chemical binding]; other site
1097668012001	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668012002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012003	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668012004	dimerization interface [polypeptide binding]; other site
1097668012005	4Fe-4S binding domain; Region: Fer4; pfam00037
1097668012006	enoyl-CoA hydratase; Provisional; Region: PRK06494
1097668012007	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668012008	substrate binding site [chemical binding]; other site
1097668012009	oxyanion hole (OAH) forming residues; other site
1097668012010	trimer interface [polypeptide binding]; other site
1097668012011	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1097668012012	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668012013	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668012014	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1097668012015	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668012016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012017	dimer interface [polypeptide binding]; other site
1097668012018	conserved gate region; other site
1097668012019	putative PBP binding loops; other site
1097668012020	ABC-ATPase subunit interface; other site
1097668012021	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668012022	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668012023	Walker A/P-loop; other site
1097668012024	ATP binding site [chemical binding]; other site
1097668012025	Q-loop/lid; other site
1097668012026	ABC transporter signature motif; other site
1097668012027	Walker B; other site
1097668012028	D-loop; other site
1097668012029	H-loop/switch region; other site
1097668012030	NMT1/THI5 like; Region: NMT1; pfam09084
1097668012031	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1097668012032	membrane-bound complex binding site; other site
1097668012033	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668012034	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668012035	trimer interface [polypeptide binding]; other site
1097668012036	eyelet of channel; other site
1097668012037	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1097668012038	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1097668012039	Chromate transporter; Region: Chromate_transp; pfam02417
1097668012040	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
1097668012041	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1097668012042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097668012043	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1097668012044	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668012045	Walker A/P-loop; other site
1097668012046	ATP binding site [chemical binding]; other site
1097668012047	Q-loop/lid; other site
1097668012048	ABC transporter signature motif; other site
1097668012049	Walker B; other site
1097668012050	D-loop; other site
1097668012051	H-loop/switch region; other site
1097668012052	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1097668012053	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1097668012054	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1097668012055	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1097668012056	urea carboxylase; Region: urea_carbox; TIGR02712
1097668012057	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097668012058	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668012059	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1097668012060	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1097668012061	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1097668012062	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1097668012063	carboxyltransferase (CT) interaction site; other site
1097668012064	biotinylation site [posttranslational modification]; other site
1097668012065	allophanate hydrolase; Provisional; Region: PRK08186
1097668012066	Amidase; Region: Amidase; cl11426
1097668012067	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
1097668012068	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1097668012069	anti sigma factor interaction site; other site
1097668012070	regulatory phosphorylation site [posttranslational modification]; other site
1097668012071	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1097668012072	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1097668012073	ATP binding site [chemical binding]; other site
1097668012074	Mg2+ binding site [ion binding]; other site
1097668012075	G-X-G motif; other site
1097668012076	Cache domain; Region: Cache_1; pfam02743
1097668012077	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1097668012078	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1097668012079	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1097668012080	homotrimer interaction site [polypeptide binding]; other site
1097668012081	putative active site [active]
1097668012082	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668012083	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668012084	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668012085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012086	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668012087	dimerization interface [polypeptide binding]; other site
1097668012088	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668012089	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668012090	[2Fe-2S] cluster binding site [ion binding]; other site
1097668012091	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1097668012092	putative alpha subunit interface [polypeptide binding]; other site
1097668012093	putative active site [active]
1097668012094	putative substrate binding site [chemical binding]; other site
1097668012095	Fe binding site [ion binding]; other site
1097668012096	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
1097668012097	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668012098	Proline racemase; Region: Pro_racemase; pfam05544
1097668012099	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668012100	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097668012101	transcriptional regulator BetI; Validated; Region: PRK00767
1097668012102	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668012103	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1097668012104	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
1097668012105	Proline dehydrogenase; Region: Pro_dh; pfam01619
1097668012106	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668012107	NAD(P) binding site [chemical binding]; other site
1097668012108	catalytic residues [active]
1097668012109	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668012110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012111	dimer interface [polypeptide binding]; other site
1097668012112	conserved gate region; other site
1097668012113	putative PBP binding loops; other site
1097668012114	ABC-ATPase subunit interface; other site
1097668012115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012116	dimer interface [polypeptide binding]; other site
1097668012117	conserved gate region; other site
1097668012118	putative PBP binding loops; other site
1097668012119	ABC-ATPase subunit interface; other site
1097668012120	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668012121	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1097668012122	Walker A/P-loop; other site
1097668012123	ATP binding site [chemical binding]; other site
1097668012124	Q-loop/lid; other site
1097668012125	ABC transporter signature motif; other site
1097668012126	Walker B; other site
1097668012127	D-loop; other site
1097668012128	H-loop/switch region; other site
1097668012129	TOBE domain; Region: TOBE_2; pfam08402
1097668012130	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668012131	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1097668012132	NAD(P) binding site [chemical binding]; other site
1097668012133	catalytic residues [active]
1097668012134	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668012135	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668012136	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1097668012137	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1097668012138	substrate binding site [chemical binding]; other site
1097668012139	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1097668012140	substrate binding site [chemical binding]; other site
1097668012141	ligand binding site [chemical binding]; other site
1097668012142	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1097668012143	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1097668012144	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
1097668012145	active site
1097668012146	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
1097668012147	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1097668012148	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668012149	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668012150	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
1097668012151	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668012152	acyl-activating enzyme (AAE) consensus motif; other site
1097668012153	AMP binding site [chemical binding]; other site
1097668012154	active site
1097668012155	CoA binding site [chemical binding]; other site
1097668012156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012157	dimer interface [polypeptide binding]; other site
1097668012158	conserved gate region; other site
1097668012159	putative PBP binding loops; other site
1097668012160	ABC-ATPase subunit interface; other site
1097668012161	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668012162	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012163	dimer interface [polypeptide binding]; other site
1097668012164	conserved gate region; other site
1097668012165	putative PBP binding loops; other site
1097668012166	ABC-ATPase subunit interface; other site
1097668012167	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668012168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668012169	Walker A/P-loop; other site
1097668012170	ATP binding site [chemical binding]; other site
1097668012171	Q-loop/lid; other site
1097668012172	ABC transporter signature motif; other site
1097668012173	Walker B; other site
1097668012174	D-loop; other site
1097668012175	H-loop/switch region; other site
1097668012176	TOBE domain; Region: TOBE_2; pfam08402
1097668012177	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1097668012178	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668012179	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668012180	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668012181	substrate binding site [chemical binding]; other site
1097668012182	oxyanion hole (OAH) forming residues; other site
1097668012183	trimer interface [polypeptide binding]; other site
1097668012184	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
1097668012185	MbtH-like protein; Region: MbtH; cl01279
1097668012186	Cupin-like domain; Region: Cupin_8; pfam13621
1097668012187	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668012188	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668012189	acyl-activating enzyme (AAE) consensus motif; other site
1097668012190	AMP binding site [chemical binding]; other site
1097668012191	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668012192	Condensation domain; Region: Condensation; pfam00668
1097668012193	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668012194	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668012195	acyl-activating enzyme (AAE) consensus motif; other site
1097668012196	AMP binding site [chemical binding]; other site
1097668012197	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668012198	Condensation domain; Region: Condensation; pfam00668
1097668012199	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097668012200	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668012201	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668012202	acyl-activating enzyme (AAE) consensus motif; other site
1097668012203	AMP binding site [chemical binding]; other site
1097668012204	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668012205	Condensation domain; Region: Condensation; pfam00668
1097668012206	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097668012207	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668012208	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668012209	acyl-activating enzyme (AAE) consensus motif; other site
1097668012210	AMP binding site [chemical binding]; other site
1097668012211	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668012212	Condensation domain; Region: Condensation; pfam00668
1097668012213	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097668012214	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668012215	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668012216	acyl-activating enzyme (AAE) consensus motif; other site
1097668012217	AMP binding site [chemical binding]; other site
1097668012218	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668012219	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1097668012220	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1097668012221	acyl-activating enzyme (AAE) consensus motif; other site
1097668012222	AMP binding site [chemical binding]; other site
1097668012223	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668012224	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1097668012225	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668012226	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668012227	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
1097668012228	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097668012229	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1097668012230	Walker A/P-loop; other site
1097668012231	ATP binding site [chemical binding]; other site
1097668012232	Q-loop/lid; other site
1097668012233	ABC transporter signature motif; other site
1097668012234	Walker B; other site
1097668012235	D-loop; other site
1097668012236	H-loop/switch region; other site
1097668012237	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
1097668012238	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1097668012239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668012240	Walker A motif; other site
1097668012241	ATP binding site [chemical binding]; other site
1097668012242	Walker B motif; other site
1097668012243	arginine finger; other site
1097668012244	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668012245	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
1097668012246	GIY-YIG motif/motif A; other site
1097668012247	active site
1097668012248	catalytic site [active]
1097668012249	metal binding site [ion binding]; metal-binding site
1097668012250	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668012251	classical (c) SDRs; Region: SDR_c; cd05233
1097668012252	NAD(P) binding site [chemical binding]; other site
1097668012253	active site
1097668012254	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
1097668012255	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668012256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012257	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668012258	putative effector binding pocket; other site
1097668012259	dimerization interface [polypeptide binding]; other site
1097668012260	benzoate transport; Region: 2A0115; TIGR00895
1097668012261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668012262	putative substrate translocation pore; other site
1097668012263	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012264	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1097668012265	putative effector binding pocket; other site
1097668012266	putative dimerization interface [polypeptide binding]; other site
1097668012267	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668012268	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668012269	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1097668012270	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668012271	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668012272	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668012273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012274	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
1097668012275	dimerization interface [polypeptide binding]; other site
1097668012276	substrate binding pocket [chemical binding]; other site
1097668012277	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1097668012278	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1097668012279	nudix motif; other site
1097668012280	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1097668012281	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1097668012282	putative DNA binding site [nucleotide binding]; other site
1097668012283	putative homodimer interface [polypeptide binding]; other site
1097668012284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668012285	binding surface
1097668012286	TPR repeat; Region: TPR_11; pfam13414
1097668012287	TPR motif; other site
1097668012288	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668012289	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668012290	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668012291	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668012292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668012293	Walker A/P-loop; other site
1097668012294	ATP binding site [chemical binding]; other site
1097668012295	Q-loop/lid; other site
1097668012296	ABC transporter signature motif; other site
1097668012297	Walker B; other site
1097668012298	D-loop; other site
1097668012299	H-loop/switch region; other site
1097668012300	TOBE domain; Region: TOBE_2; pfam08402
1097668012301	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1097668012302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012303	dimer interface [polypeptide binding]; other site
1097668012304	conserved gate region; other site
1097668012305	putative PBP binding loops; other site
1097668012306	ABC-ATPase subunit interface; other site
1097668012307	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668012308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012309	dimer interface [polypeptide binding]; other site
1097668012310	conserved gate region; other site
1097668012311	putative PBP binding loops; other site
1097668012312	ABC-ATPase subunit interface; other site
1097668012313	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1097668012314	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1097668012315	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668012316	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1097668012317	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668012318	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668012319	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1097668012320	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668012321	Protein of unknown function, DUF488; Region: DUF488; pfam04343
1097668012322	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097668012323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668012324	Coenzyme A binding pocket [chemical binding]; other site
1097668012325	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1097668012326	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1097668012327	putative ligand binding site [chemical binding]; other site
1097668012328	NAD binding site [chemical binding]; other site
1097668012329	dimerization interface [polypeptide binding]; other site
1097668012330	catalytic site [active]
1097668012331	hypothetical protein; Provisional; Region: PRK05965
1097668012332	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668012333	inhibitor-cofactor binding pocket; inhibition site
1097668012334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668012335	catalytic residue [active]
1097668012336	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668012337	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668012338	putative DNA binding site [nucleotide binding]; other site
1097668012339	putative Zn2+ binding site [ion binding]; other site
1097668012340	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668012341	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1097668012342	tartrate dehydrogenase; Region: TTC; TIGR02089
1097668012343	succinic semialdehyde dehydrogenase; Region: PLN02278
1097668012344	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668012345	tetramerization interface [polypeptide binding]; other site
1097668012346	NAD(P) binding site [chemical binding]; other site
1097668012347	catalytic residues [active]
1097668012348	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910
1097668012349	putative active site [active]
1097668012350	Zn binding site [ion binding]; other site
1097668012351	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1097668012352	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668012353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668012354	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1097668012355	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668012356	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668012357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012358	putative PBP binding loops; other site
1097668012359	dimer interface [polypeptide binding]; other site
1097668012360	ABC-ATPase subunit interface; other site
1097668012361	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1097668012362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012363	dimer interface [polypeptide binding]; other site
1097668012364	conserved gate region; other site
1097668012365	putative PBP binding loops; other site
1097668012366	ABC-ATPase subunit interface; other site
1097668012367	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668012368	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668012369	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1097668012370	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1097668012371	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668012372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668012373	Walker A/P-loop; other site
1097668012374	ATP binding site [chemical binding]; other site
1097668012375	Q-loop/lid; other site
1097668012376	ABC transporter signature motif; other site
1097668012377	Walker B; other site
1097668012378	D-loop; other site
1097668012379	H-loop/switch region; other site
1097668012380	TOBE domain; Region: TOBE_2; pfam08402
1097668012381	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668012382	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012383	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668012384	dimerization interface [polypeptide binding]; other site
1097668012385	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668012386	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668012387	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1097668012388	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668012389	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1097668012390	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1097668012391	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1097668012392	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668012393	Walker A/P-loop; other site
1097668012394	ATP binding site [chemical binding]; other site
1097668012395	Q-loop/lid; other site
1097668012396	ABC transporter signature motif; other site
1097668012397	Walker B; other site
1097668012398	D-loop; other site
1097668012399	H-loop/switch region; other site
1097668012400	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668012401	Walker A/P-loop; other site
1097668012402	ATP binding site [chemical binding]; other site
1097668012403	Q-loop/lid; other site
1097668012404	ABC transporter signature motif; other site
1097668012405	Walker B; other site
1097668012406	D-loop; other site
1097668012407	H-loop/switch region; other site
1097668012408	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1097668012409	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1097668012410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012411	dimer interface [polypeptide binding]; other site
1097668012412	conserved gate region; other site
1097668012413	ABC-ATPase subunit interface; other site
1097668012414	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097668012415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012416	dimer interface [polypeptide binding]; other site
1097668012417	conserved gate region; other site
1097668012418	putative PBP binding loops; other site
1097668012419	ABC-ATPase subunit interface; other site
1097668012420	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668012421	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1097668012422	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668012423	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668012424	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1097668012425	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668012426	motif II; other site
1097668012427	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668012428	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668012429	NAD(P) binding site [chemical binding]; other site
1097668012430	catalytic residues [active]
1097668012431	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1097668012432	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1097668012433	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668012434	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1097668012435	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1097668012436	putative active site [active]
1097668012437	putative FMN binding site [chemical binding]; other site
1097668012438	putative catalytic residue [active]
1097668012439	putative substrate binding site [chemical binding]; other site
1097668012440	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668012441	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668012442	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012443	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668012444	dimerization interface [polypeptide binding]; other site
1097668012445	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668012446	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668012447	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
1097668012448	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668012449	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012450	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1097668012451	putative dimerization interface [polypeptide binding]; other site
1097668012452	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1097668012453	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668012454	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668012455	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1097668012456	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1097668012457	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668012458	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668012459	ligand binding site [chemical binding]; other site
1097668012460	flexible hinge region; other site
1097668012461	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668012462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668012463	ATP binding site [chemical binding]; other site
1097668012464	Mg2+ binding site [ion binding]; other site
1097668012465	G-X-G motif; other site
1097668012466	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668012467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668012468	active site
1097668012469	phosphorylation site [posttranslational modification]
1097668012470	intermolecular recognition site; other site
1097668012471	dimerization interface [polypeptide binding]; other site
1097668012472	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1097668012473	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1097668012474	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668012475	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668012476	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668012477	ligand binding site [chemical binding]; other site
1097668012478	flexible hinge region; other site
1097668012479	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668012480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668012481	ATP binding site [chemical binding]; other site
1097668012482	Mg2+ binding site [ion binding]; other site
1097668012483	G-X-G motif; other site
1097668012484	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097668012485	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1097668012486	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668012487	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668012488	substrate binding pocket [chemical binding]; other site
1097668012489	membrane-bound complex binding site; other site
1097668012490	hinge residues; other site
1097668012491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668012492	dimer interface [polypeptide binding]; other site
1097668012493	phosphorylation site [posttranslational modification]
1097668012494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668012495	ATP binding site [chemical binding]; other site
1097668012496	Mg2+ binding site [ion binding]; other site
1097668012497	G-X-G motif; other site
1097668012498	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668012499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668012500	active site
1097668012501	phosphorylation site [posttranslational modification]
1097668012502	intermolecular recognition site; other site
1097668012503	dimerization interface [polypeptide binding]; other site
1097668012504	Cache domain; Region: Cache_1; pfam02743
1097668012505	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668012506	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668012507	metal binding site [ion binding]; metal-binding site
1097668012508	active site
1097668012509	I-site; other site
1097668012510	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668012511	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1097668012512	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1097668012513	active site
1097668012514	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1097668012515	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668012516	active site
1097668012517	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668012518	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1097668012519	substrate binding site [chemical binding]; other site
1097668012520	oxyanion hole (OAH) forming residues; other site
1097668012521	trimer interface [polypeptide binding]; other site
1097668012522	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668012523	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668012524	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668012525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668012526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012527	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668012528	putative effector binding pocket; other site
1097668012529	dimerization interface [polypeptide binding]; other site
1097668012530	EamA-like transporter family; Region: EamA; pfam00892
1097668012531	EamA-like transporter family; Region: EamA; pfam00892
1097668012532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668012533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012534	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668012535	dimerization interface [polypeptide binding]; other site
1097668012536	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
1097668012537	homotrimer interaction site [polypeptide binding]; other site
1097668012538	putative active site [active]
1097668012539	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
1097668012540	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1097668012541	FMN binding site [chemical binding]; other site
1097668012542	dimer interface [polypeptide binding]; other site
1097668012543	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1097668012544	active site residue [active]
1097668012545	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1097668012546	active site residue [active]
1097668012547	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1097668012548	active site residue [active]
1097668012549	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1097668012550	active site residue [active]
1097668012551	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1097668012552	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1097668012553	active site
1097668012554	non-prolyl cis peptide bond; other site
1097668012555	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1097668012556	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668012557	active site
1097668012558	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
1097668012559	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668012560	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1097668012561	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668012562	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668012563	Walker A/P-loop; other site
1097668012564	ATP binding site [chemical binding]; other site
1097668012565	Q-loop/lid; other site
1097668012566	ABC transporter signature motif; other site
1097668012567	Walker B; other site
1097668012568	D-loop; other site
1097668012569	H-loop/switch region; other site
1097668012570	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668012571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668012572	dimer interface [polypeptide binding]; other site
1097668012573	conserved gate region; other site
1097668012574	putative PBP binding loops; other site
1097668012575	ABC-ATPase subunit interface; other site
1097668012576	Predicted flavoprotein [General function prediction only]; Region: COG0431
1097668012577	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668012578	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1097668012579	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097668012580	active site
1097668012581	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1097668012582	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668012583	putative substrate translocation pore; other site
1097668012584	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
1097668012585	CHAD domain; Region: CHAD; pfam05235
1097668012586	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667
1097668012587	nudix motif; other site
1097668012588	BON domain; Region: BON; pfam04972
1097668012589	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668012590	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012591	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668012592	putative effector binding pocket; other site
1097668012593	dimerization interface [polypeptide binding]; other site
1097668012594	short chain dehydrogenase; Provisional; Region: PRK06180
1097668012595	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1097668012596	NADP binding site [chemical binding]; other site
1097668012597	active site
1097668012598	steroid binding site; other site
1097668012599	Rossmann-like domain; Region: Rossmann-like; pfam10727
1097668012600	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1097668012601	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668012602	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1097668012603	NAD(P) binding site [chemical binding]; other site
1097668012604	catalytic residues [active]
1097668012605	catalytic residues [active]
1097668012606	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1097668012607	tartrate dehydrogenase; Region: TTC; TIGR02089
1097668012608	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
1097668012609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012610	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668012611	putative dimerization interface [polypeptide binding]; other site
1097668012612	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1097668012613	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668012614	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1097668012615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668012616	SnoaL-like domain; Region: SnoaL_2; pfam12680
1097668012617	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1097668012618	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1097668012619	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
1097668012620	L-aspartate oxidase; Provisional; Region: PRK06175
1097668012621	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1097668012622	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1097668012623	SdhC subunit interface [polypeptide binding]; other site
1097668012624	proximal heme binding site [chemical binding]; other site
1097668012625	cardiolipin binding site; other site
1097668012626	Iron-sulfur protein interface; other site
1097668012627	proximal quinone binding site [chemical binding]; other site
1097668012628	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1097668012629	Iron-sulfur protein interface; other site
1097668012630	proximal quinone binding site [chemical binding]; other site
1097668012631	SdhD (CybS) interface [polypeptide binding]; other site
1097668012632	proximal heme binding site [chemical binding]; other site
1097668012633	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1097668012634	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012635	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1097668012636	putative dimerization interface [polypeptide binding]; other site
1097668012637	putative substrate binding pocket [chemical binding]; other site
1097668012638	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1097668012639	active site clefts [active]
1097668012640	zinc binding site [ion binding]; other site
1097668012641	dimer interface [polypeptide binding]; other site
1097668012642	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1097668012643	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1097668012644	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
1097668012645	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1097668012646	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1097668012647	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668012648	NMT1-like family; Region: NMT1_2; pfam13379
1097668012649	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1097668012650	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668012651	N-terminal plug; other site
1097668012652	ligand-binding site [chemical binding]; other site
1097668012653	Domain of unknown function (DU1801); Region: DUF1801; cl17490
1097668012654	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1097668012655	PAS fold; Region: PAS_4; pfam08448
1097668012656	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668012657	PAS fold; Region: PAS_3; pfam08447
1097668012658	putative active site [active]
1097668012659	heme pocket [chemical binding]; other site
1097668012660	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668012661	dimer interface [polypeptide binding]; other site
1097668012662	phosphorylation site [posttranslational modification]
1097668012663	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668012664	ATP binding site [chemical binding]; other site
1097668012665	Mg2+ binding site [ion binding]; other site
1097668012666	G-X-G motif; other site
1097668012667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668012668	active site
1097668012669	phosphorylation site [posttranslational modification]
1097668012670	dimerization interface [polypeptide binding]; other site
1097668012671	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1097668012672	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012673	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1097668012674	putative dimerization interface [polypeptide binding]; other site
1097668012675	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1097668012676	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1097668012677	THF binding site; other site
1097668012678	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1097668012679	substrate binding site [chemical binding]; other site
1097668012680	THF binding site; other site
1097668012681	zinc-binding site [ion binding]; other site
1097668012682	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668012683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668012684	metal binding site [ion binding]; metal-binding site
1097668012685	active site
1097668012686	I-site; other site
1097668012687	glutathionine S-transferase; Provisional; Region: PRK10542
1097668012688	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1097668012689	C-terminal domain interface [polypeptide binding]; other site
1097668012690	GSH binding site (G-site) [chemical binding]; other site
1097668012691	dimer interface [polypeptide binding]; other site
1097668012692	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1097668012693	N-terminal domain interface [polypeptide binding]; other site
1097668012694	dimer interface [polypeptide binding]; other site
1097668012695	substrate binding pocket (H-site) [chemical binding]; other site
1097668012696	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
1097668012697	MgtC family; Region: MgtC; pfam02308
1097668012698	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1097668012699	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1097668012700	PYR/PP interface [polypeptide binding]; other site
1097668012701	dimer interface [polypeptide binding]; other site
1097668012702	tetramer interface [polypeptide binding]; other site
1097668012703	TPP binding site [chemical binding]; other site
1097668012704	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668012705	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1097668012706	TPP-binding site [chemical binding]; other site
1097668012707	short chain dehydrogenase; Provisional; Region: PRK06701
1097668012708	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1097668012709	NAD binding site [chemical binding]; other site
1097668012710	metal binding site [ion binding]; metal-binding site
1097668012711	active site
1097668012712	CheB methylesterase; Region: CheB_methylest; pfam01339
1097668012713	CheB methylesterase; Region: CheB_methylest; pfam01339
1097668012714	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1097668012715	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1097668012716	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668012717	S-adenosylmethionine binding site [chemical binding]; other site
1097668012718	PAS fold; Region: PAS; pfam00989
1097668012719	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668012720	putative active site [active]
1097668012721	heme pocket [chemical binding]; other site
1097668012722	PAS domain; Region: PAS_10; pfam13596
1097668012723	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1097668012724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668012725	putative active site [active]
1097668012726	heme pocket [chemical binding]; other site
1097668012727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668012728	dimer interface [polypeptide binding]; other site
1097668012729	phosphorylation site [posttranslational modification]
1097668012730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668012731	ATP binding site [chemical binding]; other site
1097668012732	Mg2+ binding site [ion binding]; other site
1097668012733	G-X-G motif; other site
1097668012734	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668012735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668012736	active site
1097668012737	phosphorylation site [posttranslational modification]
1097668012738	intermolecular recognition site; other site
1097668012739	dimerization interface [polypeptide binding]; other site
1097668012740	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
1097668012741	catalytic residues [active]
1097668012742	catalytic nucleophile [active]
1097668012743	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1097668012744	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1097668012745	DNA-binding interface [nucleotide binding]; DNA binding site
1097668012746	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668012747	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1097668012748	putative FMN binding site [chemical binding]; other site
1097668012749	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668012750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668012751	NAD(P) binding site [chemical binding]; other site
1097668012752	active site
1097668012753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668012754	S-adenosylmethionine binding site [chemical binding]; other site
1097668012755	hypothetical protein; Provisional; Region: PRK06184
1097668012756	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668012757	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668012758	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668012759	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668012760	Integrase core domain; Region: rve; pfam00665
1097668012761	transposase; Validated; Region: PRK08181
1097668012762	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668012763	Walker A motif; other site
1097668012764	ATP binding site [chemical binding]; other site
1097668012765	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1097668012766	Sel1-like repeats; Region: SEL1; smart00671
1097668012767	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668012768	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668012769	putative active site [active]
1097668012770	catalytic site [active]
1097668012771	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1097668012772	Sel1-like repeats; Region: SEL1; smart00671
1097668012773	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668012774	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668012775	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668012776	putative active site [active]
1097668012777	catalytic site [active]
1097668012778	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668012779	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668012780	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668012781	putative active site [active]
1097668012782	catalytic site [active]
1097668012783	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1097668012784	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668012785	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668012786	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1097668012787	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1097668012788	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
1097668012789	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1097668012790	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1097668012791	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1097668012792	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1097668012793	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1097668012794	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668012795	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668012796	ligand binding site [chemical binding]; other site
1097668012797	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1097668012798	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1097668012799	Clp amino terminal domain; Region: Clp_N; pfam02861
1097668012800	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668012801	Walker A motif; other site
1097668012802	ATP binding site [chemical binding]; other site
1097668012803	Walker B motif; other site
1097668012804	arginine finger; other site
1097668012805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668012806	Walker A motif; other site
1097668012807	ATP binding site [chemical binding]; other site
1097668012808	Walker B motif; other site
1097668012809	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1097668012810	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
1097668012811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668012812	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668012813	putative substrate translocation pore; other site
1097668012814	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1097668012815	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668012816	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
1097668012817	acyl-activating enzyme (AAE) consensus motif; other site
1097668012818	acyl-activating enzyme (AAE) consensus motif; other site
1097668012819	putative AMP binding site [chemical binding]; other site
1097668012820	putative active site [active]
1097668012821	putative CoA binding site [chemical binding]; other site
1097668012822	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1097668012823	putative catalytic cysteine [active]
1097668012824	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668012825	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668012826	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668012827	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1097668012828	SnoaL-like domain; Region: SnoaL_2; pfam12680
1097668012829	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668012830	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668012831	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
1097668012832	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1097668012833	metal ion-dependent adhesion site (MIDAS); other site
1097668012834	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
1097668012835	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
1097668012836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1097668012837	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668012838	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668012839	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668012840	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668012841	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668012842	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668012843	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
1097668012844	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668012845	PYR/PP interface [polypeptide binding]; other site
1097668012846	dimer interface [polypeptide binding]; other site
1097668012847	TPP binding site [chemical binding]; other site
1097668012848	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668012849	Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013
1097668012850	TPP-binding site; other site
1097668012851	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1097668012852	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668012853	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668012854	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668012855	choline dehydrogenase; Validated; Region: PRK02106
1097668012856	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668012857	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668012858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668012859	putative substrate translocation pore; other site
1097668012860	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668012861	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668012862	DNA-binding site [nucleotide binding]; DNA binding site
1097668012863	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668012864	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668012865	homodimer interface [polypeptide binding]; other site
1097668012866	catalytic residue [active]
1097668012867	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1097668012868	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
1097668012869	putative heme binding pocket [chemical binding]; other site
1097668012870	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
1097668012871	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1097668012872	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668012873	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1097668012874	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668012875	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1097668012876	dimer interface [polypeptide binding]; other site
1097668012877	active site
1097668012878	metal binding site [ion binding]; metal-binding site
1097668012879	glutathione binding site [chemical binding]; other site
1097668012880	LysR family transcriptional regulator; Provisional; Region: PRK14997
1097668012881	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012882	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668012883	putative effector binding pocket; other site
1097668012884	dimerization interface [polypeptide binding]; other site
1097668012885	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668012886	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1097668012887	catalytic triad [active]
1097668012888	dimer interface [polypeptide binding]; other site
1097668012889	conserved cis-peptide bond; other site
1097668012890	choline dehydrogenase; Validated; Region: PRK02106
1097668012891	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668012892	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668012893	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1097668012894	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668012895	Cupin domain; Region: Cupin_2; cl17218
1097668012896	Fic family protein [Function unknown]; Region: COG3177
1097668012897	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
1097668012898	Fic/DOC family; Region: Fic; pfam02661
1097668012899	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1097668012900	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097668012901	EamA-like transporter family; Region: EamA; pfam00892
1097668012902	EamA-like transporter family; Region: EamA; pfam00892
1097668012903	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1097668012904	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1097668012905	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668012906	putative ligand binding site [chemical binding]; other site
1097668012907	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668012908	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668012909	TM-ABC transporter signature motif; other site
1097668012910	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668012911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668012912	Walker A/P-loop; other site
1097668012913	ATP binding site [chemical binding]; other site
1097668012914	Q-loop/lid; other site
1097668012915	ABC transporter signature motif; other site
1097668012916	Walker B; other site
1097668012917	D-loop; other site
1097668012918	H-loop/switch region; other site
1097668012919	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668012920	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668012921	DNA-binding site [nucleotide binding]; DNA binding site
1097668012922	FCD domain; Region: FCD; pfam07729
1097668012923	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1097668012924	iron-sulfur cluster [ion binding]; other site
1097668012925	[2Fe-2S] cluster binding site [ion binding]; other site
1097668012926	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
1097668012927	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
1097668012928	dimer interface [polypeptide binding]; other site
1097668012929	active site
1097668012930	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668012931	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1097668012932	active site
1097668012933	dimer interface [polypeptide binding]; other site
1097668012934	metal binding site [ion binding]; metal-binding site
1097668012935	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668012936	Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115
1097668012937	NAD(P) binding site [chemical binding]; other site
1097668012938	catalytic residues [active]
1097668012939	SnoaL-like domain; Region: SnoaL_2; pfam12680
1097668012940	Cytochrome c; Region: Cytochrom_C; cl11414
1097668012941	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
1097668012942	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
1097668012943	Helix-turn-helix domain; Region: HTH_18; pfam12833
1097668012944	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668012945	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668012946	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668012947	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668012948	putative effector binding pocket; other site
1097668012949	dimerization interface [polypeptide binding]; other site
1097668012950	Predicted permeases [General function prediction only]; Region: COG0679
1097668012951	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1097668012952	heme binding pocket [chemical binding]; other site
1097668012953	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
1097668012954	Protein of unknown function (DUF3268); Region: DUF3268; pfam11672
1097668012955	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1097668012956	ParB-like nuclease domain; Region: ParB; smart00470
1097668012957	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
1097668012958	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668012959	P-loop; other site
1097668012960	Magnesium ion binding site [ion binding]; other site
1097668012961	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668012962	Magnesium ion binding site [ion binding]; other site
1097668012963	Initiator Replication protein; Region: Rep_3; cl17676
1097668012964	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668012965	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668012966	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
1097668012967	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1097668012968	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1097668012969	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1097668012970	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1097668012971	nudix motif; other site
1097668012972	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668012973	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
1097668012974	putative ADP-binding pocket [chemical binding]; other site
1097668012975	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1097668012976	dimer interface [polypeptide binding]; other site
1097668012977	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1097668012978	active site
1097668012979	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1097668012980	Ligand Binding Site [chemical binding]; other site
1097668012981	Molecular Tunnel; other site
1097668012982	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1097668012983	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
1097668012984	Mg++ binding site [ion binding]; other site
1097668012985	putative catalytic motif [active]
1097668012986	tyrosine kinase; Provisional; Region: PRK11519
1097668012987	Chain length determinant protein; Region: Wzz; pfam02706
1097668012988	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1097668012989	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668012990	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
1097668012991	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1097668012992	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1097668012993	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1097668012994	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668012995	putative ADP-binding pocket [chemical binding]; other site
1097668012996	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
1097668012997	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
1097668012998	NAD binding site [chemical binding]; other site
1097668012999	substrate binding site [chemical binding]; other site
1097668013000	homodimer interface [polypeptide binding]; other site
1097668013001	active site
1097668013002	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668013003	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
1097668013004	putative ADP-binding pocket [chemical binding]; other site
1097668013005	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668013006	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
1097668013007	putative ADP-binding pocket [chemical binding]; other site
1097668013008	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1097668013009	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u5; cd10929
1097668013010	putative active site [active]
1097668013011	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097668013012	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1097668013013	MviN-like protein; Region: MVIN; pfam03023
1097668013014	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1097668013015	Transglycosylase; Region: Transgly; pfam00912
1097668013016	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1097668013017	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668013018	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668013019	putative DNA binding site [nucleotide binding]; other site
1097668013020	putative Zn2+ binding site [ion binding]; other site
1097668013021	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668013022	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1097668013023	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
1097668013024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668013025	catalytic residue [active]
1097668013026	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1097668013027	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1097668013028	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1097668013029	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1097668013030	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1097668013031	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097668013032	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097668013033	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668013034	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668013035	ligand binding site [chemical binding]; other site
1097668013036	flexible hinge region; other site
1097668013037	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097668013038	non-specific DNA interactions [nucleotide binding]; other site
1097668013039	DNA binding site [nucleotide binding]
1097668013040	sequence specific DNA binding site [nucleotide binding]; other site
1097668013041	putative cAMP binding site [chemical binding]; other site
1097668013042	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1097668013043	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668013044	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1097668013045	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013047	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668013048	dimerization interface [polypeptide binding]; other site
1097668013049	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668013050	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1097668013051	NAD(P) binding site [chemical binding]; other site
1097668013052	catalytic residues [active]
1097668013053	putative MFS family transporter protein; Provisional; Region: PRK03633
1097668013054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013055	putative substrate translocation pore; other site
1097668013056	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1097668013057	benzoate transport; Region: 2A0115; TIGR00895
1097668013058	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013059	putative substrate translocation pore; other site
1097668013060	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013061	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1097668013062	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668013063	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1097668013064	active site
1097668013065	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
1097668013066	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668013067	putative active site [active]
1097668013068	putative metal binding site [ion binding]; other site
1097668013069	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668013070	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1097668013071	NAD(P) binding site [chemical binding]; other site
1097668013072	catalytic residues [active]
1097668013073	L-aspartate dehydrogenase; Provisional; Region: PRK13303
1097668013074	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1097668013075	Domain of unknown function DUF108; Region: DUF108; pfam01958
1097668013076	hypothetical protein; Provisional; Region: PRK07064
1097668013077	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668013078	PYR/PP interface [polypeptide binding]; other site
1097668013079	dimer interface [polypeptide binding]; other site
1097668013080	TPP binding site [chemical binding]; other site
1097668013081	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668013082	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1097668013083	TPP-binding site [chemical binding]; other site
1097668013084	short chain dehydrogenase; Provisional; Region: PRK07062
1097668013085	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1097668013086	putative NAD(P) binding site [chemical binding]; other site
1097668013087	putative active site [active]
1097668013088	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668013089	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668013090	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668013091	Serine hydrolase; Region: Ser_hydrolase; cl17834
1097668013092	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668013093	Cupin domain; Region: Cupin_2; pfam07883
1097668013094	short chain dehydrogenase; Provisional; Region: PRK12939
1097668013095	classical (c) SDRs; Region: SDR_c; cd05233
1097668013096	NAD(P) binding site [chemical binding]; other site
1097668013097	active site
1097668013098	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668013099	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668013100	[2Fe-2S] cluster binding site [ion binding]; other site
1097668013101	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668013102	hydrophobic ligand binding site; other site
1097668013103	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1097668013104	[2Fe-2S] cluster binding site [ion binding]; other site
1097668013105	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668013106	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668013107	trimer interface [polypeptide binding]; other site
1097668013108	eyelet of channel; other site
1097668013109	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1097668013110	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296
1097668013111	putative NAD(P) binding site [chemical binding]; other site
1097668013112	putative substrate binding site [chemical binding]; other site
1097668013113	catalytic Zn binding site [ion binding]; other site
1097668013114	structural Zn binding site [ion binding]; other site
1097668013115	Predicted thioesterase [General function prediction only]; Region: COG5496
1097668013116	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668013117	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1097668013118	acyl-activating enzyme (AAE) consensus motif; other site
1097668013119	AMP binding site [chemical binding]; other site
1097668013120	active site
1097668013121	CoA binding site [chemical binding]; other site
1097668013122	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668013123	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668013124	substrate binding site [chemical binding]; other site
1097668013125	oxyanion hole (OAH) forming residues; other site
1097668013126	trimer interface [polypeptide binding]; other site
1097668013127	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1097668013128	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1097668013129	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668013130	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668013131	dimerization interface [polypeptide binding]; other site
1097668013132	ligand binding site [chemical binding]; other site
1097668013133	PAS fold; Region: PAS; pfam00989
1097668013134	PAS domain; Region: PAS; smart00091
1097668013135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668013136	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1097668013137	Walker A motif; other site
1097668013138	ATP binding site [chemical binding]; other site
1097668013139	Walker B motif; other site
1097668013140	arginine finger; other site
1097668013141	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668013142	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668013143	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1097668013144	FAD binding pocket [chemical binding]; other site
1097668013145	FAD binding motif [chemical binding]; other site
1097668013146	phosphate binding motif [ion binding]; other site
1097668013147	beta-alpha-beta structure motif; other site
1097668013148	NAD binding pocket [chemical binding]; other site
1097668013149	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668013150	catalytic loop [active]
1097668013151	iron binding site [ion binding]; other site
1097668013152	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1097668013153	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668013154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668013155	non-specific DNA binding site [nucleotide binding]; other site
1097668013156	salt bridge; other site
1097668013157	sequence-specific DNA binding site [nucleotide binding]; other site
1097668013158	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1097668013159	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1097668013160	dimer interface [polypeptide binding]; other site
1097668013161	active site
1097668013162	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1097668013163	folate binding site [chemical binding]; other site
1097668013164	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1097668013165	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668013166	Coenzyme A binding pocket [chemical binding]; other site
1097668013167	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1097668013168	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668013169	NAD(P) binding site [chemical binding]; other site
1097668013170	active site
1097668013171	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
1097668013172	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
1097668013173	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668013174	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668013175	DNA binding residues [nucleotide binding]
1097668013176	dimerization interface [polypeptide binding]; other site
1097668013177	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668013178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668013179	active site
1097668013180	phosphorylation site [posttranslational modification]
1097668013181	intermolecular recognition site; other site
1097668013182	dimerization interface [polypeptide binding]; other site
1097668013183	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668013184	DNA binding site [nucleotide binding]
1097668013185	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1097668013186	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
1097668013187	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668013188	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668013189	conserved cys residue [active]
1097668013190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668013191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013192	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668013193	putative substrate translocation pore; other site
1097668013194	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1097668013195	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1097668013196	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
1097668013197	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668013198	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1097668013199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668013200	Walker A motif; other site
1097668013201	ATP binding site [chemical binding]; other site
1097668013202	Walker B motif; other site
1097668013203	arginine finger; other site
1097668013204	Peptidase family M41; Region: Peptidase_M41; pfam01434
1097668013205	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1097668013206	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1097668013207	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1097668013208	homotrimer interaction site [polypeptide binding]; other site
1097668013209	putative active site [active]
1097668013210	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668013211	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668013212	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1097668013213	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1097668013214	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668013215	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668013216	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668013217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668013218	dimer interface [polypeptide binding]; other site
1097668013219	conserved gate region; other site
1097668013220	putative PBP binding loops; other site
1097668013221	ABC-ATPase subunit interface; other site
1097668013222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668013223	putative PBP binding loops; other site
1097668013224	dimer interface [polypeptide binding]; other site
1097668013225	ABC-ATPase subunit interface; other site
1097668013226	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668013227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668013228	Walker A/P-loop; other site
1097668013229	ATP binding site [chemical binding]; other site
1097668013230	Q-loop/lid; other site
1097668013231	ABC transporter signature motif; other site
1097668013232	Walker B; other site
1097668013233	D-loop; other site
1097668013234	H-loop/switch region; other site
1097668013235	TOBE domain; Region: TOBE_2; pfam08402
1097668013236	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668013237	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1097668013238	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1097668013239	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013240	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668013241	dimerization interface [polypeptide binding]; other site
1097668013242	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1097668013243	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1097668013244	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1097668013245	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1097668013246	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1097668013247	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1097668013248	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
1097668013249	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1097668013250	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668013251	ATP binding site [chemical binding]; other site
1097668013252	putative Mg++ binding site [ion binding]; other site
1097668013253	Protein of unknown function DUF45; Region: DUF45; pfam01863
1097668013254	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1097668013255	Helix-turn-helix domain; Region: HTH_38; pfam13936
1097668013256	Homeodomain-like domain; Region: HTH_32; pfam13565
1097668013257	Integrase core domain; Region: rve; pfam00665
1097668013258	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1097668013259	dimer interface [polypeptide binding]; other site
1097668013260	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668013261	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668013262	DNA binding site [nucleotide binding]
1097668013263	domain linker motif; other site
1097668013264	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668013265	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1097668013266	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668013267	ligand binding site [chemical binding]; other site
1097668013268	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668013269	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668013270	Walker A/P-loop; other site
1097668013271	ATP binding site [chemical binding]; other site
1097668013272	Q-loop/lid; other site
1097668013273	ABC transporter signature motif; other site
1097668013274	Walker B; other site
1097668013275	D-loop; other site
1097668013276	H-loop/switch region; other site
1097668013277	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668013278	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668013279	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668013280	TM-ABC transporter signature motif; other site
1097668013281	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668013282	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668013283	TM-ABC transporter signature motif; other site
1097668013284	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1097668013285	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097668013286	DNA interaction; other site
1097668013287	Metal-binding active site; metal-binding site
1097668013288	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097668013289	conserved cys residue [active]
1097668013290	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668013291	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1097668013292	inhibitor-cofactor binding pocket; inhibition site
1097668013293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668013294	catalytic residue [active]
1097668013295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013296	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
1097668013297	putative dimerization interface [polypeptide binding]; other site
1097668013298	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668013299	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668013300	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668013301	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668013302	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1097668013303	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668013304	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668013305	active site
1097668013306	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668013307	classical (c) SDRs; Region: SDR_c; cd05233
1097668013308	NAD(P) binding site [chemical binding]; other site
1097668013309	active site
1097668013310	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668013311	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668013312	tetramer interface [polypeptide binding]; other site
1097668013313	active site
1097668013314	Mg2+/Mn2+ binding site [ion binding]; other site
1097668013315	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1097668013316	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013317	putative substrate translocation pore; other site
1097668013318	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668013319	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097668013320	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668013321	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668013322	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668013323	Predicted transcriptional regulators [Transcription]; Region: COG1733
1097668013324	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1097668013325	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013327	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1097668013328	putative effector binding pocket; other site
1097668013329	putative dimerization interface [polypeptide binding]; other site
1097668013330	Oxygenase domain of the 2OGFeDO superfamily; Region: Tet_JBP; pfam12851
1097668013331	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1097668013332	intersubunit interface [polypeptide binding]; other site
1097668013333	active site
1097668013334	catalytic residue [active]
1097668013335	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
1097668013336	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668013337	NAD(P) binding site [chemical binding]; other site
1097668013338	catalytic residues [active]
1097668013339	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668013340	NAD(P) binding site [chemical binding]; other site
1097668013341	catalytic residues [active]
1097668013342	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
1097668013343	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1097668013344	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1097668013345	substrate binding site [chemical binding]; other site
1097668013346	dimer interface [polypeptide binding]; other site
1097668013347	ATP binding site [chemical binding]; other site
1097668013348	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668013349	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668013350	TM-ABC transporter signature motif; other site
1097668013351	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1097668013352	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668013353	ligand binding site [chemical binding]; other site
1097668013354	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668013355	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668013356	Walker A/P-loop; other site
1097668013357	ATP binding site [chemical binding]; other site
1097668013358	Q-loop/lid; other site
1097668013359	ABC transporter signature motif; other site
1097668013360	Walker B; other site
1097668013361	D-loop; other site
1097668013362	H-loop/switch region; other site
1097668013363	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668013364	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668013365	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668013366	TM-ABC transporter signature motif; other site
1097668013367	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1097668013368	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1097668013369	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1097668013370	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668013371	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1097668013372	conserved cys residue [active]
1097668013373	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668013374	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668013375	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1097668013376	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1097668013377	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1097668013378	Domain of unknown function (DUF202); Region: DUF202; cl09954
1097668013379	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
1097668013380	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668013381	FeS/SAM binding site; other site
1097668013382	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1097668013383	SEC-C motif; Region: SEC-C; pfam02810
1097668013384	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1097668013385	Sulfatase; Region: Sulfatase; pfam00884
1097668013386	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
1097668013387	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1097668013388	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1097668013389	substrate binding site [chemical binding]; other site
1097668013390	ligand binding site [chemical binding]; other site
1097668013391	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1097668013392	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1097668013393	substrate binding site [chemical binding]; other site
1097668013394	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1097668013395	tartrate dehydrogenase; Region: TTC; TIGR02089
1097668013396	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668013397	NMT1-like family; Region: NMT1_2; pfam13379
1097668013398	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668013399	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668013400	Walker A/P-loop; other site
1097668013401	ATP binding site [chemical binding]; other site
1097668013402	Q-loop/lid; other site
1097668013403	ABC transporter signature motif; other site
1097668013404	Walker B; other site
1097668013405	D-loop; other site
1097668013406	H-loop/switch region; other site
1097668013407	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668013408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668013409	dimer interface [polypeptide binding]; other site
1097668013410	conserved gate region; other site
1097668013411	putative PBP binding loops; other site
1097668013412	ABC-ATPase subunit interface; other site
1097668013413	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668013414	classical (c) SDRs; Region: SDR_c; cd05233
1097668013415	NAD(P) binding site [chemical binding]; other site
1097668013416	active site
1097668013417	NMT1-like family; Region: NMT1_2; pfam13379
1097668013418	NMT1/THI5 like; Region: NMT1; pfam09084
1097668013419	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097668013420	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013421	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013422	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668013423	putative dimerization interface [polypeptide binding]; other site
1097668013424	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1097668013425	active site
1097668013426	trehalose synthase; Region: treS_nterm; TIGR02456
1097668013427	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1097668013428	active site
1097668013429	catalytic site [active]
1097668013430	GYD domain; Region: GYD; pfam08734
1097668013431	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1097668013432	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1097668013433	oligomer interface [polypeptide binding]; other site
1097668013434	metal binding site [ion binding]; metal-binding site
1097668013435	metal binding site [ion binding]; metal-binding site
1097668013436	putative Cl binding site [ion binding]; other site
1097668013437	basic sphincter; other site
1097668013438	hydrophobic gate; other site
1097668013439	periplasmic entrance; other site
1097668013440	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097668013441	GAF domain; Region: GAF; pfam01590
1097668013442	PAS domain S-box; Region: sensory_box; TIGR00229
1097668013443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668013444	putative active site [active]
1097668013445	heme pocket [chemical binding]; other site
1097668013446	PAS fold; Region: PAS_4; pfam08448
1097668013447	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668013448	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668013449	metal binding site [ion binding]; metal-binding site
1097668013450	active site
1097668013451	I-site; other site
1097668013452	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1097668013453	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668013454	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013455	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668013456	dimerization interface [polypeptide binding]; other site
1097668013457	substrate binding pocket [chemical binding]; other site
1097668013458	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668013459	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668013460	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668013461	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668013462	Ligand binding site [chemical binding]; other site
1097668013463	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668013464	HutD; Region: HutD; pfam05962
1097668013465	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668013466	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668013467	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1097668013468	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668013469	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668013470	DNA-binding site [nucleotide binding]; DNA binding site
1097668013471	FCD domain; Region: FCD; pfam07729
1097668013472	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668013473	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668013474	TM-ABC transporter signature motif; other site
1097668013475	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668013476	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668013477	TM-ABC transporter signature motif; other site
1097668013478	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668013479	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668013480	Walker A/P-loop; other site
1097668013481	ATP binding site [chemical binding]; other site
1097668013482	Q-loop/lid; other site
1097668013483	ABC transporter signature motif; other site
1097668013484	Walker B; other site
1097668013485	D-loop; other site
1097668013486	H-loop/switch region; other site
1097668013487	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668013488	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1097668013489	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668013490	putative ligand binding site [chemical binding]; other site
1097668013491	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1097668013492	Flagellar L-ring protein; Region: FlgH; pfam02107
1097668013493	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668013494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668013495	active site
1097668013496	phosphorylation site [posttranslational modification]
1097668013497	intermolecular recognition site; other site
1097668013498	dimerization interface [polypeptide binding]; other site
1097668013499	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668013500	DNA binding site [nucleotide binding]
1097668013501	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1097668013502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668013503	active site
1097668013504	phosphorylation site [posttranslational modification]
1097668013505	intermolecular recognition site; other site
1097668013506	dimerization interface [polypeptide binding]; other site
1097668013507	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668013508	DNA binding site [nucleotide binding]
1097668013509	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668013510	dimerization interface [polypeptide binding]; other site
1097668013511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668013512	dimer interface [polypeptide binding]; other site
1097668013513	phosphorylation site [posttranslational modification]
1097668013514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668013515	ATP binding site [chemical binding]; other site
1097668013516	Mg2+ binding site [ion binding]; other site
1097668013517	G-X-G motif; other site
1097668013518	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1097668013519	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1097668013520	D-lactate dehydrogenase; Provisional; Region: PRK11183
1097668013521	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668013522	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
1097668013523	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668013524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013525	putative substrate translocation pore; other site
1097668013526	DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990
1097668013527	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668013528	DNA-binding site [nucleotide binding]; DNA binding site
1097668013529	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668013530	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013531	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013532	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1097668013533	putative effector binding pocket; other site
1097668013534	putative dimerization interface [polypeptide binding]; other site
1097668013535	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1097668013536	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668013537	NAD binding site [chemical binding]; other site
1097668013538	catalytic residues [active]
1097668013539	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1097668013540	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1097668013541	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
1097668013542	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668013543	N-terminal plug; other site
1097668013544	ligand-binding site [chemical binding]; other site
1097668013545	putative S-transferase; Provisional; Region: PRK11752
1097668013546	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1097668013547	C-terminal domain interface [polypeptide binding]; other site
1097668013548	GSH binding site (G-site) [chemical binding]; other site
1097668013549	dimer interface [polypeptide binding]; other site
1097668013550	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1097668013551	dimer interface [polypeptide binding]; other site
1097668013552	N-terminal domain interface [polypeptide binding]; other site
1097668013553	active site
1097668013554	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1097668013555	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668013556	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668013557	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097668013558	active site
1097668013559	metal binding site [ion binding]; metal-binding site
1097668013560	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
1097668013561	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1097668013562	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1097668013563	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
1097668013564	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668013565	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1097668013566	homodimer interface [polypeptide binding]; other site
1097668013567	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1097668013568	active site pocket [active]
1097668013569	GAF domain; Region: GAF; cl17456
1097668013570	Predicted transcriptional regulators [Transcription]; Region: COG1733
1097668013571	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1097668013572	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1097668013573	RibD C-terminal domain; Region: RibD_C; cl17279
1097668013574	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1097668013575	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1097668013576	catalytic residues [active]
1097668013577	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
1097668013578	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
1097668013579	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013580	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013581	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668013582	dimerization interface [polypeptide binding]; other site
1097668013583	malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808
1097668013584	Malonate transporter MadL subunit; Region: MadL; cl04273
1097668013585	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668013586	Proline racemase; Region: Pro_racemase; pfam05544
1097668013587	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668013588	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668013589	active site
1097668013590	catalytic tetrad [active]
1097668013591	H-NS histone family; Region: Histone_HNS; pfam00816
1097668013592	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1097668013593	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1097668013594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668013595	motif II; other site
1097668013596	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013597	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013598	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668013599	dimerization interface [polypeptide binding]; other site
1097668013600	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668013601	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668013602	dimerization interface [polypeptide binding]; other site
1097668013603	ligand binding site [chemical binding]; other site
1097668013604	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668013605	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1097668013606	putative Zn2+ binding site [ion binding]; other site
1097668013607	putative DNA binding site [nucleotide binding]; other site
1097668013608	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668013609	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1097668013610	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1097668013611	metal binding site [ion binding]; metal-binding site
1097668013612	putative dimer interface [polypeptide binding]; other site
1097668013613	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
1097668013614	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1097668013615	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668013616	catalytic residue [active]
1097668013617	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
1097668013618	iron-sulfur cluster [ion binding]; other site
1097668013619	[2Fe-2S] cluster binding site [ion binding]; other site
1097668013620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013621	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668013622	putative substrate translocation pore; other site
1097668013623	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1097668013624	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668013625	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668013626	trimer interface [polypeptide binding]; other site
1097668013627	eyelet of channel; other site
1097668013628	BON domain; Region: BON; pfam04972
1097668013629	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1097668013630	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1097668013631	dimer interface [polypeptide binding]; other site
1097668013632	acyl-activating enzyme (AAE) consensus motif; other site
1097668013633	putative active site [active]
1097668013634	AMP binding site [chemical binding]; other site
1097668013635	putative CoA binding site [chemical binding]; other site
1097668013636	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1097668013637	putative active site [active]
1097668013638	putative catalytic site [active]
1097668013639	poly(R)-hydroxyalkanoic acid synthase, class II; Region: PHA_synth_II; TIGR01839
1097668013640	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1097668013641	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
1097668013642	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668013643	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668013644	trimer interface [polypeptide binding]; other site
1097668013645	eyelet of channel; other site
1097668013646	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013648	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1097668013649	putative dimerization interface [polypeptide binding]; other site
1097668013650	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
1097668013651	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668013652	substrate binding site [chemical binding]; other site
1097668013653	oxyanion hole (OAH) forming residues; other site
1097668013654	trimer interface [polypeptide binding]; other site
1097668013655	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668013656	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668013657	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668013658	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668013659	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668013660	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1097668013661	putative hydrophobic ligand binding site [chemical binding]; other site
1097668013662	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1097668013663	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1097668013664	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668013665	fumarylacetoacetase; Region: PLN02856
1097668013666	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1097668013667	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668013668	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1097668013669	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668013670	Zn binding site [ion binding]; other site
1097668013671	salicylate hydroxylase; Provisional; Region: PRK08163
1097668013672	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668013673	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
1097668013674	Flavoprotein; Region: Flavoprotein; pfam02441
1097668013675	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668013676	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668013677	trimer interface [polypeptide binding]; other site
1097668013678	eyelet of channel; other site
1097668013679	benzoate transport; Region: 2A0115; TIGR00895
1097668013680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013681	putative substrate translocation pore; other site
1097668013682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013683	benzoate transport; Region: 2A0115; TIGR00895
1097668013684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013685	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668013686	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668013687	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668013688	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1097668013689	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668013690	substrate binding pocket [chemical binding]; other site
1097668013691	membrane-bound complex binding site; other site
1097668013692	hinge residues; other site
1097668013693	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1097668013694	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1097668013695	YheO-like PAS domain; Region: PAS_6; pfam08348
1097668013696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1097668013697	HTH domain; Region: HTH_22; pfam13309
1097668013698	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668013699	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668013700	active site
1097668013701	catalytic tetrad [active]
1097668013702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013704	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668013705	dimerization interface [polypeptide binding]; other site
1097668013706	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1097668013707	trimer interface [polypeptide binding]; other site
1097668013708	putative Zn binding site [ion binding]; other site
1097668013709	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668013710	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668013711	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668013712	dimerization interface [polypeptide binding]; other site
1097668013713	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668013714	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
1097668013715	putative active site [active]
1097668013716	metal binding site [ion binding]; metal-binding site
1097668013717	enoyl-CoA hydratase; Provisional; Region: PRK06127
1097668013718	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668013719	substrate binding site [chemical binding]; other site
1097668013720	oxyanion hole (OAH) forming residues; other site
1097668013721	trimer interface [polypeptide binding]; other site
1097668013722	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668013723	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668013724	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1097668013725	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1097668013726	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1097668013727	DctM-like transporters; Region: DctM; pfam06808
1097668013728	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1097668013729	Predicted thioesterase [General function prediction only]; Region: COG5496
1097668013730	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668013731	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668013732	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668013733	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668013734	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
1097668013735	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
1097668013736	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
1097668013737	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668013738	Walker A motif; other site
1097668013739	ATP binding site [chemical binding]; other site
1097668013740	Walker B motif; other site
1097668013741	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668013742	Walker A motif; other site
1097668013743	ATP binding site [chemical binding]; other site
1097668013744	Walker B motif; other site
1097668013745	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668013746	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668013747	dimer interface [polypeptide binding]; other site
1097668013748	phosphorylation site [posttranslational modification]
1097668013749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668013750	ATP binding site [chemical binding]; other site
1097668013751	Mg2+ binding site [ion binding]; other site
1097668013752	G-X-G motif; other site
1097668013753	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668013754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668013755	active site
1097668013756	phosphorylation site [posttranslational modification]
1097668013757	intermolecular recognition site; other site
1097668013758	dimerization interface [polypeptide binding]; other site
1097668013759	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1097668013760	nudix motif; other site
1097668013761	RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607
1097668013762	active site
1097668013763	barstar interaction site; other site
1097668013764	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1097668013765	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668013766	putative active site [active]
1097668013767	metal binding site [ion binding]; metal-binding site
1097668013768	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668013769	WHG domain; Region: WHG; pfam13305
1097668013770	NnrU protein; Region: NnrU; pfam07298
1097668013771	Hemerythrin-like domain; Region: Hr-like; cd12108
1097668013772	Fe binding site [ion binding]; other site
1097668013773	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668013774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668013775	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668013776	Transposase; Region: HTH_Tnp_1; pfam01527
1097668013777	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668013778	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1097668013779	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668013780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013781	putative substrate translocation pore; other site
1097668013782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668013783	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1097668013784	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668013785	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668013786	E3 interaction surface; other site
1097668013787	lipoyl attachment site [posttranslational modification]; other site
1097668013788	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668013789	MarR family; Region: MarR_2; cl17246
1097668013790	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668013791	PII uridylyl-transferase; Provisional; Region: PRK03059
1097668013792	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668013793	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668013794	DNA-binding site [nucleotide binding]; DNA binding site
1097668013795	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668013796	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668013797	homodimer interface [polypeptide binding]; other site
1097668013798	catalytic residue [active]
1097668013799	Cupin domain; Region: Cupin_2; pfam07883
1097668013800	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668013801	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1097668013802	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668013803	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668013804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668013805	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668013806	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1097668013807	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668013808	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668013809	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668013810	Transposase; Region: HTH_Tnp_1; pfam01527
1097668013811	Phage integrase protein; Region: DUF3701; pfam12482
1097668013812	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1097668013813	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1097668013814	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
1097668013815	Int/Topo IB signature motif; other site
1097668013816	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097668013817	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668013818	Magnesium ion binding site [ion binding]; other site
1097668013819	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1097668013820	ParB-like nuclease domain; Region: ParB; smart00470
1097668013821	KorB domain; Region: KorB; pfam08535
1097668013822	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668013823	PAS domain; Region: PAS_9; pfam13426
1097668013824	putative active site [active]
1097668013825	heme pocket [chemical binding]; other site
1097668013826	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668013827	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668013828	metal binding site [ion binding]; metal-binding site
1097668013829	I-site; other site
1097668013830	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668013831	PAS domain S-box; Region: sensory_box; TIGR00229
1097668013832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668013833	putative active site [active]
1097668013834	heme pocket [chemical binding]; other site
1097668013835	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668013836	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668013837	metal binding site [ion binding]; metal-binding site
1097668013838	active site
1097668013839	I-site; other site
1097668013840	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668013841	HDOD domain; Region: HDOD; pfam08668
1097668013842	flap endonuclease-like protein; Provisional; Region: PRK09482
1097668013843	PIN domain of bacteriophage T3, T4 RNase H, T5-5'nuclease, and homologs; Region: PIN_T4-like; cd09860
1097668013844	active site
1097668013845	metal binding site 1 [ion binding]; metal-binding site
1097668013846	5' ssDNA interaction site; other site
1097668013847	3' ssDNA interaction site; other site
1097668013848	metal binding site 2 [ion binding]; metal-binding site
1097668013849	H3TH domain of bacteriophage T3, T4 RNase H, T5-5' nucleases, and homologs; Region: H3TH_T4-like; cd09899
1097668013850	DNA binding site [nucleotide binding]
1097668013851	metal binding site [ion binding]; metal-binding site
1097668013852	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1097668013853	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1097668013854	generic binding surface II; other site
1097668013855	generic binding surface I; other site
1097668013856	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1097668013857	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
1097668013858	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1097668013859	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
1097668013860	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
1097668013861	RDD family; Region: RDD; pfam06271
1097668013862	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
1097668013863	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1097668013864	active site
1097668013865	substrate binding site [chemical binding]; other site
1097668013866	Mg2+ binding site [ion binding]; other site
1097668013867	VRR-NUC domain; Region: VRR_NUC; pfam08774
1097668013868	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1097668013869	Mg binding site [ion binding]; other site
1097668013870	nucleotide binding site [chemical binding]; other site
1097668013871	putative protofilament interface [polypeptide binding]; other site
1097668013872	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1097668013873	AAA domain; Region: AAA_30; pfam13604
1097668013874	Family description; Region: UvrD_C_2; pfam13538
1097668013875	BON domain; Region: BON; pfam04972
1097668013876	CHASE2 domain; Region: CHASE2; cl01732
1097668013877	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668013878	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668013879	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668013880	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668013881	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1097668013882	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668013883	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668013884	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668013885	Transposase; Region: HTH_Tnp_1; pfam01527
1097668013886	RNA polymerase sigma factor; Reviewed; Region: PRK12523
1097668013887	Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426
1097668013888	polypeptide substrate binding site [polypeptide binding]; other site
1097668013889	active site
1097668013890	Protein of unknown function DUF72; Region: DUF72; pfam01904
1097668013891	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1097668013892	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1097668013893	putative active site [active]
1097668013894	putative PHP Thumb interface [polypeptide binding]; other site
1097668013895	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1097668013896	generic binding surface II; other site
1097668013897	generic binding surface I; other site
1097668013898	DNA Polymerase Y-family; Region: PolY_like; cd03468
1097668013899	active site
1097668013900	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1097668013901	DNA binding site [nucleotide binding]
1097668013902	Uncharacterized conserved protein [Function unknown]; Region: COG4544
1097668013903	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1097668013904	active site
1097668013905	DNA binding site [nucleotide binding]
1097668013906	DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776
1097668013907	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1097668013908	DNA binding site [nucleotide binding]
1097668013909	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
1097668013910	nucleotide binding site [chemical binding]; other site
1097668013911	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097668013912	Helix-turn-helix domain; Region: HTH_17; pfam12728
1097668013913	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1097668013914	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668013915	binding surface
1097668013916	TPR motif; other site
1097668013917	TPR repeat; Region: TPR_11; pfam13414
1097668013918	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1097668013919	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1097668013920	putative DNA binding site [nucleotide binding]; other site
1097668013921	putative homodimer interface [polypeptide binding]; other site
1097668013922	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1097668013923	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1097668013924	DNA methylase; Region: N6_N4_Mtase; pfam01555
1097668013925	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
1097668013926	Domain of unknown function (DUF1817); Region: DUF1817; cl02292
1097668013927	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1097668013928	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1097668013929	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
1097668013930	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1097668013931	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
1097668013932	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668013933	non-specific DNA binding site [nucleotide binding]; other site
1097668013934	salt bridge; other site
1097668013935	sequence-specific DNA binding site [nucleotide binding]; other site
1097668013936	Protein of unknown function DUF91; Region: DUF91; cl00709
1097668013937	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
1097668013938	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
1097668013939	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668013940	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
1097668013941	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1097668013942	Protein of unknown function (DUF1643); Region: DUF1643; cl01787
1097668013943	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1097668013944	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1097668013945	hypothetical protein; Provisional; Region: PRK14013
1097668013946	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1097668013947	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1097668013948	putative metal binding site [ion binding]; other site
1097668013949	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
1097668013950	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
1097668013951	signal peptidase I; Provisional; Region: PRK10861
1097668013952	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097668013953	Catalytic site [active]
1097668013954	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1097668013955	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1097668013956	catalytic motif [active]
1097668013957	Catalytic residue [active]
1097668013958	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1097668013959	HD domain; Region: HD_4; pfam13328
1097668013960	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1097668013961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668013962	active site
1097668013963	phosphorylation site [posttranslational modification]
1097668013964	intermolecular recognition site; other site
1097668013965	dimerization interface [polypeptide binding]; other site
1097668013966	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097668013967	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1097668013968	non-specific DNA binding site [nucleotide binding]; other site
1097668013969	salt bridge; other site
1097668013970	sequence-specific DNA binding site [nucleotide binding]; other site
1097668013971	ParB-like nuclease domain; Region: ParBc; cl02129
1097668013972	KorB domain; Region: KorB; pfam08535
1097668013973	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
1097668013974	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668013975	active site
1097668013976	metal binding site [ion binding]; metal-binding site
1097668013977	Flagellin N-methylase; Region: FliB; pfam03692
1097668013978	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1097668013979	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1097668013980	active site
1097668013981	putative substrate binding region [chemical binding]; other site
1097668013982	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
1097668013983	Autotransporter beta-domain; Region: Autotransporter; pfam03797
1097668013984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668013985	H-NS histone family; Region: Histone_HNS; pfam00816
1097668013986	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1097668013987	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668013988	putative transposase OrfB; Reviewed; Region: PHA02517
1097668013989	Integrase core domain; Region: rve; pfam00665
1097668013990	Integrase core domain; Region: rve_3; pfam13683
1097668013991	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668013992	Ligand Binding Site [chemical binding]; other site
1097668013993	AAA-like domain; Region: AAA_10; pfam12846
1097668013994	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1097668013995	catalytic site [active]
1097668013996	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1097668013997	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668013998	active site
1097668013999	Int/Topo IB signature motif; other site
1097668014000	DNA binding site [nucleotide binding]
1097668014001	SdiA-regulated; Region: SdiA-regulated; pfam06977
1097668014002	SdiA-regulated; Region: SdiA-regulated; cd09971
1097668014003	putative active site [active]
1097668014004	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668014005	Ligand Binding Site [chemical binding]; other site
1097668014006	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668014007	Ligand Binding Site [chemical binding]; other site
1097668014008	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1097668014009	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1097668014010	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1097668014011	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1097668014012	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1097668014013	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1097668014014	catalytic residues [active]
1097668014015	catalytic nucleophile [active]
1097668014016	Presynaptic Site I dimer interface [polypeptide binding]; other site
1097668014017	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1097668014018	Synaptic Flat tetramer interface [polypeptide binding]; other site
1097668014019	Synaptic Site I dimer interface [polypeptide binding]; other site
1097668014020	DNA binding site [nucleotide binding]
1097668014021	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1097668014022	DNA-binding interface [nucleotide binding]; DNA binding site
1097668014023	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1097668014024	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1097668014025	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1097668014026	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1097668014027	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
1097668014028	oligomer interface [polypeptide binding]; other site
1097668014029	metal binding site [ion binding]; metal-binding site
1097668014030	metal binding site [ion binding]; metal-binding site
1097668014031	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1097668014032	putative Cl binding site [ion binding]; other site
1097668014033	aspartate ring; other site
1097668014034	basic sphincter; other site
1097668014035	hydrophobic gate; other site
1097668014036	periplasmic entrance; other site
1097668014037	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1097668014038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668014039	NAD(P) binding site [chemical binding]; other site
1097668014040	active site
1097668014041	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1097668014042	mce related protein; Region: MCE; pfam02470
1097668014043	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1097668014044	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668014045	Walker A/P-loop; other site
1097668014046	ATP binding site [chemical binding]; other site
1097668014047	Q-loop/lid; other site
1097668014048	ABC transporter signature motif; other site
1097668014049	Walker B; other site
1097668014050	D-loop; other site
1097668014051	H-loop/switch region; other site
1097668014052	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1097668014053	Permease; Region: Permease; pfam02405
1097668014054	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668014055	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1097668014056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668014057	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
1097668014058	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668014059	Integrase core domain; Region: rve; pfam00665
1097668014060	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
1097668014061	SprT-like family; Region: SprT-like; pfam10263
1097668014062	SprT homologues; Region: SprT; cl01182
1097668014063	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668014064	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668014065	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668014066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668014067	non-specific DNA binding site [nucleotide binding]; other site
1097668014068	salt bridge; other site
1097668014069	sequence-specific DNA binding site [nucleotide binding]; other site
1097668014070	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1097668014071	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1097668014072	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668014073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668014074	active site
1097668014075	phosphorylation site [posttranslational modification]
1097668014076	intermolecular recognition site; other site
1097668014077	dimerization interface [polypeptide binding]; other site
1097668014078	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668014079	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668014080	metal binding site [ion binding]; metal-binding site
1097668014081	active site
1097668014082	I-site; other site
1097668014083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1097668014084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1097668014085	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1097668014086	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
1097668014087	MgtC family; Region: MgtC; pfam02308
1097668014088	Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111
1097668014089	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097668014090	DNA binding residues [nucleotide binding]
1097668014091	alkylmercury lyase; Provisional; Region: PRK13239
1097668014092	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
1097668014093	Alkylmercury lyase; Region: MerB; pfam03243
1097668014094	mercuric reductase; Region: MerA; TIGR02053
1097668014095	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668014096	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668014097	Membrane transport protein MerF; Region: Transport_MerF; pfam11431
1097668014098	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1097668014099	metal-binding site [ion binding]
1097668014100	MerT mercuric transport protein; Region: MerT; cl03578
1097668014101	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
1097668014102	DNA binding residues [nucleotide binding]
1097668014103	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
1097668014104	dimer interface [polypeptide binding]; other site
1097668014105	putative metal binding site [ion binding]; other site
1097668014106	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1097668014107	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1097668014108	catalytic residues [active]
1097668014109	catalytic nucleophile [active]
1097668014110	Presynaptic Site I dimer interface [polypeptide binding]; other site
1097668014111	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1097668014112	Synaptic Flat tetramer interface [polypeptide binding]; other site
1097668014113	Synaptic Site I dimer interface [polypeptide binding]; other site
1097668014114	DNA binding site [nucleotide binding]
1097668014115	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1097668014116	DNA-binding interface [nucleotide binding]; DNA binding site
1097668014117	Integrase core domain; Region: rve; pfam00665
1097668014118	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1097668014119	Bacterial TniB protein; Region: TniB; pfam05621
1097668014120	TniQ; Region: TniQ; pfam06527
1097668014121	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1097668014122	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1097668014123	catalytic residues [active]
1097668014124	catalytic nucleophile [active]
1097668014125	Presynaptic Site I dimer interface [polypeptide binding]; other site
1097668014126	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1097668014127	Synaptic Flat tetramer interface [polypeptide binding]; other site
1097668014128	Synaptic Site I dimer interface [polypeptide binding]; other site
1097668014129	DNA binding site [nucleotide binding]
1097668014130	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1097668014131	DNA-binding interface [nucleotide binding]; DNA binding site
1097668014132	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
1097668014133	Domain of unknown function (DUF3330); Region: DUF3330; pfam11809
1097668014134	putative mercury resistance protein; Provisional; Region: PRK13747
1097668014135	transcriptional regulator MerD; Provisional; Region: PRK13749
1097668014136	Helix-Turn-Helix DNA binding domain of the MerD transcription regulator; Region: HTH_MerD; cd01111
1097668014137	DNA binding residues [nucleotide binding]
1097668014138	putative dimer interface [polypeptide binding]; other site
1097668014139	alkylmercury lyase; Provisional; Region: PRK13239
1097668014140	Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324
1097668014141	Alkylmercury lyase; Region: MerB; pfam03243
1097668014142	putative transcriptional regulator MerR; Provisional; Region: PRK13752
1097668014143	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
1097668014144	DNA binding residues [nucleotide binding]
1097668014145	dimer interface [polypeptide binding]; other site
1097668014146	mercury binding site [ion binding]; other site
1097668014147	SprT-like family; Region: SprT-like; pfam10263
1097668014148	SprT homologues; Region: SprT; cl01182
1097668014149	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
1097668014150	dimerization domain [polypeptide binding]; other site
1097668014151	dimer interface [polypeptide binding]; other site
1097668014152	catalytic residues [active]
1097668014153	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
1097668014154	TraU protein; Region: TraU; pfam06834
1097668014155	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
1097668014156	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1097668014157	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1097668014158	dimer interface [polypeptide binding]; other site
1097668014159	ssDNA binding site [nucleotide binding]; other site
1097668014160	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1097668014161	recombination associated protein; Reviewed; Region: rdgC; PRK00321
1097668014162	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1097668014163	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1097668014164	nucleotide binding pocket [chemical binding]; other site
1097668014165	K-X-D-G motif; other site
1097668014166	catalytic site [active]
1097668014167	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1097668014168	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1097668014169	Dimer interface [polypeptide binding]; other site
1097668014170	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1097668014171	replicative DNA helicase; Region: DnaB; TIGR00665
1097668014172	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1097668014173	Walker A motif; other site
1097668014174	ATP binding site [chemical binding]; other site
1097668014175	Walker B motif; other site
1097668014176	DNA binding loops [nucleotide binding]
1097668014177	Protein of unknown function (DUF1376); Region: DUF1376; cl01531
1097668014178	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1097668014179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1097668014180	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1097668014181	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1097668014182	active site
1097668014183	metal binding site [ion binding]; metal-binding site
1097668014184	interdomain interaction site; other site
1097668014185	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1097668014186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668014187	ATP binding site [chemical binding]; other site
1097668014188	Mg2+ binding site [ion binding]; other site
1097668014189	G-X-G motif; other site
1097668014190	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1097668014191	anchoring element; other site
1097668014192	dimer interface [polypeptide binding]; other site
1097668014193	ATP binding site [chemical binding]; other site
1097668014194	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1097668014195	active site
1097668014196	metal binding site [ion binding]; metal-binding site
1097668014197	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1097668014198	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1097668014199	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1097668014200	CAP-like domain; other site
1097668014201	active site
1097668014202	primary dimer interface [polypeptide binding]; other site
1097668014203	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1097668014204	Peptidase M15; Region: Peptidase_M15_3; cl01194
1097668014205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1097668014206	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1097668014207	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1097668014208	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1097668014209	AAA-like domain; Region: AAA_10; pfam12846
1097668014210	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668014211	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668014212	ligand binding site [chemical binding]; other site
1097668014213	TraL protein; Region: TraL; cl06278
1097668014214	TraE protein; Region: TraE; cl05060
1097668014215	TraK protein; Region: TraK; pfam06586
1097668014216	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
1097668014217	GET complex subunit GET2; Region: GET2; pfam08690
1097668014218	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1097668014219	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
1097668014220	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
1097668014221	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
1097668014222	Domain of unknown function DUF87; Region: DUF87; pfam01935
1097668014223	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
1097668014224	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
1097668014225	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
1097668014226	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
1097668014227	F plasmid transfer operon protein; Region: TraF; pfam13728
1097668014228	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
1097668014229	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
1097668014230	Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649
1097668014231	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668014232	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1097668014233	catalytic residues [active]
1097668014234	hinge region; other site
1097668014235	alpha helical domain; other site
1097668014236	Type II/IV secretion system protein; Region: T2SE; pfam00437
1097668014237	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668014238	Walker A motif; other site
1097668014239	ATP binding site [chemical binding]; other site
1097668014240	Walker B motif; other site
1097668014241	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1097668014242	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668014243	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668014244	catalytic residue [active]
1097668014245	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1097668014246	Sel1-like repeats; Region: SEL1; smart00671
1097668014247	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1097668014248	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1097668014249	active site
1097668014250	dimer interface [polypeptide binding]; other site
1097668014251	effector binding site; other site
1097668014252	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
1097668014253	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876
1097668014254	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
1097668014255	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
1097668014256	ATP-dependent DNA helicase RecG; Region: recG; TIGR00643
1097668014257	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1097668014258	generic binding surface I; other site
1097668014259	generic binding surface II; other site
1097668014260	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668014261	ATP binding site [chemical binding]; other site
1097668014262	putative Mg++ binding site [ion binding]; other site
1097668014263	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668014264	nucleotide binding region [chemical binding]; other site
1097668014265	ATP-binding site [chemical binding]; other site
1097668014266	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1097668014267	metal ion-dependent adhesion site (MIDAS); other site
1097668014268	MoxR-like ATPases [General function prediction only]; Region: COG0714
1097668014269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668014270	Walker A motif; other site
1097668014271	ATP binding site [chemical binding]; other site
1097668014272	Walker B motif; other site
1097668014273	Protein of unknown function (DUF3150); Region: DUF3150; pfam11348
1097668014274	DNA topoisomerase III; Provisional; Region: PRK07726
1097668014275	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1097668014276	active site
1097668014277	putative interdomain interaction site [polypeptide binding]; other site
1097668014278	putative metal-binding site [ion binding]; other site
1097668014279	putative nucleotide binding site [chemical binding]; other site
1097668014280	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1097668014281	domain I; other site
1097668014282	phosphate binding site [ion binding]; other site
1097668014283	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1097668014284	domain II; other site
1097668014285	domain III; other site
1097668014286	nucleotide binding site [chemical binding]; other site
1097668014287	DNA binding groove [nucleotide binding]
1097668014288	catalytic site [active]
1097668014289	domain IV; other site
1097668014290	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
1097668014291	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1097668014292	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1097668014293	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
1097668014294	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1097668014295	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1097668014296	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1097668014297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668014298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668014299	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668014300	putative effector binding pocket; other site
1097668014301	dimerization interface [polypeptide binding]; other site
1097668014302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1097668014303	HTH-like domain; Region: HTH_21; pfam13276
1097668014304	Integrase core domain; Region: rve; pfam00665
1097668014305	Integrase core domain; Region: rve_3; pfam13683
1097668014306	Transposase; Region: HTH_Tnp_1; pfam01527
1097668014307	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668014308	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668014309	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668014310	putative effector binding pocket; other site
1097668014311	dimerization interface [polypeptide binding]; other site
1097668014312	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1097668014313	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668014314	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1097668014315	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668014316	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668014317	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668014318	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668014319	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668014320	benzoate transport; Region: 2A0115; TIGR00895
1097668014321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014322	putative substrate translocation pore; other site
1097668014323	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668014324	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668014325	trimer interface [polypeptide binding]; other site
1097668014326	eyelet of channel; other site
1097668014327	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1097668014328	iron-sulfur cluster [ion binding]; other site
1097668014329	[2Fe-2S] cluster binding site [ion binding]; other site
1097668014330	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
1097668014331	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
1097668014332	dimer interface [polypeptide binding]; other site
1097668014333	active site
1097668014334	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668014335	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1097668014336	active site
1097668014337	dimer interface [polypeptide binding]; other site
1097668014338	metal binding site [ion binding]; metal-binding site
1097668014339	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668014340	Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115
1097668014341	NAD(P) binding site [chemical binding]; other site
1097668014342	catalytic residues [active]
1097668014343	Transposase; Region: HTH_Tnp_1; cl17663
1097668014344	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668014345	IS2 transposase TnpB; Reviewed; Region: PRK09409
1097668014346	HTH-like domain; Region: HTH_21; pfam13276
1097668014347	Integrase core domain; Region: rve; pfam00665
1097668014348	Integrase core domain; Region: rve_3; pfam13683
1097668014349	FAD binding domain; Region: FAD_binding_3; pfam01494
1097668014350	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668014351	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668014352	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
1097668014353	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668014354	FAD binding domain; Region: FAD_binding_3; pfam01494
1097668014355	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668014356	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
1097668014357	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668014358	DNA binding site [nucleotide binding]
1097668014359	Int/Topo IB signature motif; other site
1097668014360	active site
1097668014361	catalytic residues [active]
1097668014362	Helix-turn-helix domain; Region: HTH_17; pfam12728
1097668014363	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
1097668014364	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
1097668014365	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
1097668014366	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1097668014367	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668014368	ATP binding site [chemical binding]; other site
1097668014369	putative Mg++ binding site [ion binding]; other site
1097668014370	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668014371	nucleotide binding region [chemical binding]; other site
1097668014372	ATP-binding site [chemical binding]; other site
1097668014373	Abortive infection C-terminus; Region: Abi_C; pfam14355
1097668014374	AAA domain; Region: AAA_23; pfam13476
1097668014375	AAA domain; Region: AAA_21; pfam13304
1097668014376	RloB-like protein; Region: RloB; pfam13707
1097668014377	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668014378	active site
1097668014379	metal binding site [ion binding]; metal-binding site
1097668014380	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
1097668014381	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1097668014382	nudix motif; other site
1097668014383	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1097668014384	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1097668014385	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1097668014386	nudix motif; other site
1097668014387	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097668014388	IHF dimer interface [polypeptide binding]; other site
1097668014389	IHF - DNA interface [nucleotide binding]; other site
1097668014390	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1097668014391	NAD-dependent deacetylase; Provisional; Region: PRK00481
1097668014392	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1097668014393	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
1097668014394	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1097668014395	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
1097668014396	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1097668014397	Family description; Region: UvrD_C_2; pfam13538
1097668014398	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
1097668014399	AAA domain; Region: AAA_30; pfam13604
1097668014400	Family description; Region: UvrD_C_2; pfam13538
1097668014401	WYL domain; Region: WYL; pfam13280
1097668014402	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1097668014403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668014404	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668014405	dimerization interface [polypeptide binding]; other site
1097668014406	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668014407	hypothetical protein; Provisional; Region: PRK06126
1097668014408	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668014409	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1097668014410	active site
1097668014411	metal binding site [ion binding]; metal-binding site
1097668014412	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
1097668014413	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668014414	putative active site [active]
1097668014415	putative metal binding site [ion binding]; other site
1097668014416	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668014417	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668014418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014419	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668014420	putative substrate translocation pore; other site
1097668014421	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097668014422	classical (c) SDRs; Region: SDR_c; cd05233
1097668014423	NAD(P) binding site [chemical binding]; other site
1097668014424	active site
1097668014425	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1097668014426	MULE transposase domain; Region: MULE; pfam10551
1097668014427	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014428	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668014429	putative substrate translocation pore; other site
1097668014430	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668014431	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668014432	trimer interface [polypeptide binding]; other site
1097668014433	eyelet of channel; other site
1097668014434	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1097668014435	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668014436	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1097668014437	catalytic triad [active]
1097668014438	dimer interface [polypeptide binding]; other site
1097668014439	conserved cis-peptide bond; other site
1097668014440	N-terminal domain of MhqB, a type I extradiol dioxygenase, and similar proteins; Region: MhqB_like_N; cd08344
1097668014441	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
1097668014442	C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360
1097668014443	putative active site [active]
1097668014444	putative metal binding site [ion binding]; other site
1097668014445	hypothetical protein; Provisional; Region: PRK06126
1097668014446	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668014447	hypothetical protein; Provisional; Region: PRK07236
1097668014448	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668014449	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668014450	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1097668014451	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668014452	DNA-binding site [nucleotide binding]; DNA binding site
1097668014453	FCD domain; Region: FCD; pfam07729
1097668014454	Pirin-related protein [General function prediction only]; Region: COG1741
1097668014455	Pirin; Region: Pirin; pfam02678
1097668014456	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1097668014457	LysR family transcriptional regulator; Provisional; Region: PRK14997
1097668014458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668014459	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1097668014460	putative effector binding pocket; other site
1097668014461	putative dimerization interface [polypeptide binding]; other site
1097668014462	Homeodomain-like domain; Region: HTH_23; pfam13384
1097668014463	Winged helix-turn helix; Region: HTH_29; pfam13551
1097668014464	Homeodomain-like domain; Region: HTH_32; pfam13565
1097668014465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668014466	PAS domain; Region: PAS_9; pfam13426
1097668014467	putative active site [active]
1097668014468	heme pocket [chemical binding]; other site
1097668014469	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668014470	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668014471	DNA binding residues [nucleotide binding]
1097668014472	dimerization interface [polypeptide binding]; other site
1097668014473	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
1097668014474	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1097668014475	active site
1097668014476	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1097668014477	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668014478	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1097668014479	acyl-activating enzyme (AAE) consensus motif; other site
1097668014480	acyl-activating enzyme (AAE) consensus motif; other site
1097668014481	putative AMP binding site [chemical binding]; other site
1097668014482	putative active site [active]
1097668014483	putative CoA binding site [chemical binding]; other site
1097668014484	FAD binding domain; Region: FAD_binding_3; pfam01494
1097668014485	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668014486	N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267
1097668014487	The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257
1097668014488	putative active site [active]
1097668014489	putative metal binding site [ion binding]; other site
1097668014490	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1097668014491	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668014492	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668014493	trimer interface [polypeptide binding]; other site
1097668014494	eyelet of channel; other site
1097668014495	BON domain; Region: BON; pfam04972
1097668014496	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668014497	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668014498	Arc-like DNA binding domain; Region: Arc; pfam03869
1097668014499	conserved hypothetical protein; Region: TIGR03843
1097668014500	TrbC/VIRB2 family; Region: TrbC; pfam04956
1097668014501	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
1097668014502	type IV secretion system ATPase VirB4; Provisional; Region: PRK13898
1097668014503	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1097668014504	Type IV secretion system proteins; Region: T4SS; pfam07996
1097668014505	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1097668014506	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1097668014507	VirB8 protein; Region: VirB8; pfam04335
1097668014508	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1097668014509	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1097668014510	VirB7 interaction site; other site
1097668014511	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1097668014512	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1097668014513	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1097668014514	Walker A motif; other site
1097668014515	hexamer interface [polypeptide binding]; other site
1097668014516	ATP binding site [chemical binding]; other site
1097668014517	Walker B motif; other site
1097668014518	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668014519	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668014520	catalytic residue [active]
1097668014521	TrwC relaxase; Region: TrwC; pfam08751
1097668014522	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
1097668014523	AAA domain; Region: AAA_30; pfam13604
1097668014524	Family description; Region: UvrD_C_2; pfam13538
1097668014525	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668014526	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
1097668014527	Walker A motif; other site
1097668014528	ATP binding site [chemical binding]; other site
1097668014529	Walker B motif; other site
1097668014530	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1097668014531	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1097668014532	TrfA protein; Region: TrfA; pfam07042
1097668014533	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1097668014534	Helix-turn-helix domain; Region: HTH_17; pfam12728
1097668014535	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668014536	P-loop; other site
1097668014537	Magnesium ion binding site [ion binding]; other site
1097668014538	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668014539	Magnesium ion binding site [ion binding]; other site
1097668014540	ParB-like nuclease domain; Region: ParBc; pfam02195
1097668014541	KorB domain; Region: KorB; pfam08535
1097668014542	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668014543	DNA-binding site [nucleotide binding]; DNA binding site
1097668014544	RNA-binding motif; other site
1097668014545	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668014546	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668014547	DNA binding site [nucleotide binding]
1097668014548	domain linker motif; other site
1097668014549	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1097668014550	putative dimerization interface [polypeptide binding]; other site
1097668014551	putative ligand binding site [chemical binding]; other site
1097668014552	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
1097668014553	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1097668014554	classical (c) SDRs; Region: SDR_c; cd05233
1097668014555	NAD(P) binding site [chemical binding]; other site
1097668014556	active site
1097668014557	Photosystem II protein; Region: PSII; cl08223
1097668014558	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1097668014559	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1097668014560	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1097668014561	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668014562	dimerization interface [polypeptide binding]; other site
1097668014563	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668014564	dimer interface [polypeptide binding]; other site
1097668014565	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1097668014566	putative CheW interface [polypeptide binding]; other site
1097668014567	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1097668014568	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1097668014569	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668014570	S-adenosylmethionine binding site [chemical binding]; other site
1097668014571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668014572	TPR repeat; Region: TPR_11; pfam13414
1097668014573	binding surface
1097668014574	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1097668014575	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1097668014576	putative binding surface; other site
1097668014577	active site
1097668014578	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668014579	ATP binding site [chemical binding]; other site
1097668014580	Mg2+ binding site [ion binding]; other site
1097668014581	G-X-G motif; other site
1097668014582	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1097668014583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668014584	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668014585	active site
1097668014586	phosphorylation site [posttranslational modification]
1097668014587	intermolecular recognition site; other site
1097668014588	dimerization interface [polypeptide binding]; other site
1097668014589	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
1097668014590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668014591	active site
1097668014592	phosphorylation site [posttranslational modification]
1097668014593	intermolecular recognition site; other site
1097668014594	CheB methylesterase; Region: CheB_methylest; pfam01339
1097668014595	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668014596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668014597	active site
1097668014598	phosphorylation site [posttranslational modification]
1097668014599	intermolecular recognition site; other site
1097668014600	dimerization interface [polypeptide binding]; other site
1097668014601	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668014602	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668014603	metal binding site [ion binding]; metal-binding site
1097668014604	active site
1097668014605	I-site; other site
1097668014606	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668014607	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668014608	active site
1097668014609	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668014610	catalytic tetrad [active]
1097668014611	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1097668014612	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1097668014613	Cl- selectivity filter; other site
1097668014614	Cl- binding residues [ion binding]; other site
1097668014615	pore gating glutamate residue; other site
1097668014616	dimer interface [polypeptide binding]; other site
1097668014617	H+/Cl- coupling transport residue; other site
1097668014618	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668014619	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
1097668014620	putative active site [active]
1097668014621	catalytic site [active]
1097668014622	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
1097668014623	putative active site [active]
1097668014624	catalytic site [active]
1097668014625	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1097668014626	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1097668014627	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1097668014628	putative catalytic site [active]
1097668014629	putative metal binding site [ion binding]; other site
1097668014630	putative phosphate binding site [ion binding]; other site
1097668014631	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
1097668014632	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668014633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668014634	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1097668014635	putative effector binding pocket; other site
1097668014636	putative dimerization interface [polypeptide binding]; other site
1097668014637	short chain dehydrogenase; Provisional; Region: PRK12937
1097668014638	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1097668014639	NADP binding site [chemical binding]; other site
1097668014640	homodimer interface [polypeptide binding]; other site
1097668014641	active site
1097668014642	substrate binding site [chemical binding]; other site
1097668014643	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1097668014644	active site
1097668014645	catalytic site [active]
1097668014646	substrate binding site [chemical binding]; other site
1097668014647	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
1097668014648	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1097668014649	GIY-YIG motif/motif A; other site
1097668014650	active site
1097668014651	catalytic site [active]
1097668014652	putative DNA binding site [nucleotide binding]; other site
1097668014653	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1097668014654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1097668014655	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1097668014656	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668014657	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1097668014658	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097668014659	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
1097668014660	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
1097668014661	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1097668014662	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580
1097668014663	putative active site [active]
1097668014664	catalytic site [active]
1097668014665	putative metal binding site [ion binding]; other site
1097668014666	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668014667	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668014668	trimer interface [polypeptide binding]; other site
1097668014669	eyelet of channel; other site
1097668014670	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1097668014671	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668014672	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668014673	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668014674	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1097668014675	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1097668014676	molybdopterin cofactor binding site; other site
1097668014677	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
1097668014678	PAC2 family; Region: PAC2; cl00847
1097668014679	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
1097668014680	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1097668014681	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1097668014682	toxin ChpB; Provisional; Region: PRK09812
1097668014683	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
1097668014684	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
1097668014685	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
1097668014686	selenocysteine synthase; Provisional; Region: PRK04311
1097668014687	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
1097668014688	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668014689	catalytic residue [active]
1097668014690	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
1097668014691	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
1097668014692	G1 box; other site
1097668014693	putative GEF interaction site [polypeptide binding]; other site
1097668014694	GTP/Mg2+ binding site [chemical binding]; other site
1097668014695	Switch I region; other site
1097668014696	G2 box; other site
1097668014697	G3 box; other site
1097668014698	Switch II region; other site
1097668014699	G4 box; other site
1097668014700	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1097668014701	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
1097668014702	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
1097668014703	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1097668014704	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1097668014705	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097668014706	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1097668014707	active site
1097668014708	LssY C-terminus; Region: LssY_C; pfam14067
1097668014709	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097668014710	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1097668014711	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668014712	active site
1097668014713	DNA binding site [nucleotide binding]
1097668014714	Int/Topo IB signature motif; other site
1097668014715	Domain of unknown function (DUF4224); Region: DUF4224; pfam13986
1097668014716	Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065
1097668014717	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668014718	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668014719	non-specific DNA binding site [nucleotide binding]; other site
1097668014720	salt bridge; other site
1097668014721	sequence-specific DNA binding site [nucleotide binding]; other site
1097668014722	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1097668014723	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
1097668014724	Predicted transcriptional regulator [Transcription]; Region: COG2932
1097668014725	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1097668014726	Catalytic site [active]
1097668014727	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1097668014728	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
1097668014729	Helix-turn-helix domain; Region: HTH_36; pfam13730
1097668014730	Phage endonuclease I; Region: Phage_endo_I; cl11622
1097668014731	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
1097668014732	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
1097668014733	Protein of unknown function (DUF2591); Region: DUF2591; cl11584
1097668014734	Terminase small subunit; Region: Terminase_2; cl01513
1097668014735	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1097668014736	Phage portal protein; Region: Phage_portal; pfam04860
1097668014737	Phage-related protein [Function unknown]; Region: COG4695
1097668014738	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
1097668014739	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1097668014740	Phage capsid family; Region: Phage_capsid; pfam05065
1097668014741	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1097668014742	oligomerization interface [polypeptide binding]; other site
1097668014743	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1097668014744	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
1097668014745	Phage major tail protein 2; Region: Phage_tail_2; cl11463
1097668014746	Protein of unknown function (DUF4035); Region: DUF4035; pfam13227
1097668014747	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
1097668014748	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
1097668014749	Phage-related minor tail protein [Function unknown]; Region: COG5281
1097668014750	phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541
1097668014751	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
1097668014752	Phage minor tail protein; Region: Phage_min_tail; pfam05939
1097668014753	Phage-related protein [Function unknown]; Region: gp18; COG4672
1097668014754	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073
1097668014755	MPN+ (JAMM) motif; other site
1097668014756	Zinc-binding site [ion binding]; other site
1097668014757	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1097668014758	NlpC/P60 family; Region: NLPC_P60; cl17555
1097668014759	Phage-related protein, tail component [Function unknown]; Region: COG4723
1097668014760	Phage-related protein, tail component [Function unknown]; Region: COG4733
1097668014761	Putative phage tail protein; Region: Phage-tail_3; pfam13550
1097668014762	Fibronectin type 3 domain; Region: FN3; smart00060
1097668014763	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
1097668014764	TniQ; Region: TniQ; pfam06527
1097668014765	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1097668014766	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1097668014767	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1097668014768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668014769	Walker A motif; other site
1097668014770	ATP binding site [chemical binding]; other site
1097668014771	Walker B motif; other site
1097668014772	arginine finger; other site
1097668014773	Peptidase family M41; Region: Peptidase_M41; pfam01434
1097668014774	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1097668014775	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668014776	putative active site [active]
1097668014777	heme pocket [chemical binding]; other site
1097668014778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668014779	dimer interface [polypeptide binding]; other site
1097668014780	phosphorylation site [posttranslational modification]
1097668014781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668014782	ATP binding site [chemical binding]; other site
1097668014783	Mg2+ binding site [ion binding]; other site
1097668014784	G-X-G motif; other site
1097668014785	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668014786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668014787	active site
1097668014788	phosphorylation site [posttranslational modification]
1097668014789	intermolecular recognition site; other site
1097668014790	dimerization interface [polypeptide binding]; other site
1097668014791	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668014792	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668014793	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1097668014794	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668014795	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668014796	acyl-activating enzyme (AAE) consensus motif; other site
1097668014797	AMP binding site [chemical binding]; other site
1097668014798	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668014799	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1097668014800	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668014801	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668014802	acyl-activating enzyme (AAE) consensus motif; other site
1097668014803	AMP binding site [chemical binding]; other site
1097668014804	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668014805	Condensation domain; Region: Condensation; pfam00668
1097668014806	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
1097668014807	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668014808	acyl-activating enzyme (AAE) consensus motif; other site
1097668014809	AMP binding site [chemical binding]; other site
1097668014810	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668014811	Condensation domain; Region: Condensation; pfam00668
1097668014812	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668014813	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668014814	acyl-activating enzyme (AAE) consensus motif; other site
1097668014815	AMP binding site [chemical binding]; other site
1097668014816	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668014817	Condensation domain; Region: Condensation; pfam00668
1097668014818	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668014819	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668014820	acyl-activating enzyme (AAE) consensus motif; other site
1097668014821	AMP binding site [chemical binding]; other site
1097668014822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668014823	S-adenosylmethionine binding site [chemical binding]; other site
1097668014824	Predicted permeases [General function prediction only]; Region: COG0679
1097668014825	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1097668014826	Phage Tail Collar Domain; Region: Collar; pfam07484
1097668014827	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1097668014828	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097668014829	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1097668014830	Walker A/P-loop; other site
1097668014831	ATP binding site [chemical binding]; other site
1097668014832	Q-loop/lid; other site
1097668014833	ABC transporter signature motif; other site
1097668014834	Walker B; other site
1097668014835	D-loop; other site
1097668014836	H-loop/switch region; other site
1097668014837	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668014838	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1097668014839	Walker A motif; other site
1097668014840	ATP binding site [chemical binding]; other site
1097668014841	Walker B motif; other site
1097668014842	arginine finger; other site
1097668014843	Peptidase family M41; Region: Peptidase_M41; pfam01434
1097668014844	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668014845	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668014846	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1097668014847	dimerization interface [polypeptide binding]; other site
1097668014848	substrate binding pocket [chemical binding]; other site
1097668014849	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
1097668014850	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
1097668014851	putative active site [active]
1097668014852	Zn binding site [ion binding]; other site
1097668014853	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014854	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668014855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014856	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668014857	MarR family; Region: MarR_2; cl17246
1097668014858	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668014859	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668014860	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1097668014861	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668014862	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668014863	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668014864	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014865	putative substrate translocation pore; other site
1097668014866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014867	BON domain; Region: BON; pfam04972
1097668014868	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668014869	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1097668014870	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668014871	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668014872	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668014873	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668014874	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1097668014875	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668014876	Transposase; Region: HTH_Tnp_1; cl17663
1097668014877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014878	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668014879	Predicted integral membrane protein [Function unknown]; Region: COG5616
1097668014880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668014881	TPR motif; other site
1097668014882	binding surface
1097668014883	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1097668014884	Predicted membrane protein [Function unknown]; Region: COG4129
1097668014885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1097668014886	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1097668014887	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1097668014888	DNA-binding site [nucleotide binding]; DNA binding site
1097668014889	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668014890	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1097668014891	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668014892	homodimer interface [polypeptide binding]; other site
1097668014893	catalytic residue [active]
1097668014894	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
1097668014895	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1097668014896	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1097668014897	putative active site [active]
1097668014898	catalytic triad [active]
1097668014899	putative dimer interface [polypeptide binding]; other site
1097668014900	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
1097668014901	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668014902	FeS/SAM binding site; other site
1097668014903	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668014904	Coenzyme A binding pocket [chemical binding]; other site
1097668014905	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
1097668014906	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
1097668014907	dimerization interface [polypeptide binding]; other site
1097668014908	putative ATP binding site [chemical binding]; other site
1097668014909	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
1097668014910	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1097668014911	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668014912	probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099
1097668014913	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1097668014914	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
1097668014915	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1097668014916	B12 binding site [chemical binding]; other site
1097668014917	cobalt ligand [ion binding]; other site
1097668014918	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668014919	dimer interface [polypeptide binding]; other site
1097668014920	putative CheW interface [polypeptide binding]; other site
1097668014921	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1097668014922	nucleoside/Zn binding site; other site
1097668014923	dimer interface [polypeptide binding]; other site
1097668014924	catalytic motif [active]
1097668014925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668014926	active site
1097668014927	phosphorylation site [posttranslational modification]
1097668014928	intermolecular recognition site; other site
1097668014929	Autotransporter beta-domain; Region: Autotransporter; smart00869
1097668014930	hypothetical protein; Provisional; Region: PRK10621
1097668014931	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1097668014932	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1097668014933	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668014934	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668014935	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097668014936	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668014937	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1097668014938	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1097668014939	putative active site [active]
1097668014940	putative FMN binding site [chemical binding]; other site
1097668014941	putative substrate binding site [chemical binding]; other site
1097668014942	putative catalytic residue [active]
1097668014943	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668014944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668014945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668014946	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1097668014947	putative NAD(P) binding site [chemical binding]; other site
1097668014948	homodimer interface [polypeptide binding]; other site
1097668014949	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668014950	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668014951	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668014952	dimer interface [polypeptide binding]; other site
1097668014953	catalytic residue [active]
1097668014954	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1097668014955	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668014956	substrate binding pocket [chemical binding]; other site
1097668014957	membrane-bound complex binding site; other site
1097668014958	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668014959	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
1097668014960	Walker A/P-loop; other site
1097668014961	ATP binding site [chemical binding]; other site
1097668014962	Q-loop/lid; other site
1097668014963	ABC transporter signature motif; other site
1097668014964	Walker B; other site
1097668014965	D-loop; other site
1097668014966	H-loop/switch region; other site
1097668014967	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1097668014968	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1097668014969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668014970	dimer interface [polypeptide binding]; other site
1097668014971	conserved gate region; other site
1097668014972	putative PBP binding loops; other site
1097668014973	ABC-ATPase subunit interface; other site
1097668014974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668014975	dimer interface [polypeptide binding]; other site
1097668014976	conserved gate region; other site
1097668014977	ABC-ATPase subunit interface; other site
1097668014978	betaine aldehyde dehydrogenase; Region: PLN02467
1097668014979	Arabidopsis betaine aldehyde dehydrogenase 1 and 2, ALDH family 10A8 and 10A9-like; Region: ALDH_F10_BADH; cd07110
1097668014980	NAD(P) binding site [chemical binding]; other site
1097668014981	catalytic residues [active]
1097668014982	catalytic residues [active]
1097668014983	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668014984	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1097668014985	[2Fe-2S] cluster binding site [ion binding]; other site
1097668014986	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668014987	hydrophobic ligand binding site; other site
1097668014988	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668014989	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668014990	trimer interface [polypeptide binding]; other site
1097668014991	eyelet of channel; other site
1097668014992	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668014993	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668014994	shikimate binding site; other site
1097668014995	NAD(P) binding site [chemical binding]; other site
1097668014996	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668014997	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668014998	DNA-binding site [nucleotide binding]; DNA binding site
1097668014999	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668015000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015001	homodimer interface [polypeptide binding]; other site
1097668015002	catalytic residue [active]
1097668015003	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1097668015004	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1097668015005	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668015006	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668015007	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1097668015008	[2Fe-2S] cluster binding site [ion binding]; other site
1097668015009	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1097668015010	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1097668015011	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1097668015012	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668015013	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668015014	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
1097668015015	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668015016	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668015017	dimerization interface [polypeptide binding]; other site
1097668015018	ligand binding site [chemical binding]; other site
1097668015019	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668015020	MarR family; Region: MarR_2; cl17246
1097668015021	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015022	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668015023	putative substrate translocation pore; other site
1097668015024	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668015025	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668015026	FMN-binding pocket [chemical binding]; other site
1097668015027	flavin binding motif; other site
1097668015028	phosphate binding motif [ion binding]; other site
1097668015029	beta-alpha-beta structure motif; other site
1097668015030	NAD binding pocket [chemical binding]; other site
1097668015031	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668015032	catalytic loop [active]
1097668015033	iron binding site [ion binding]; other site
1097668015034	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1097668015035	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668015036	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668015037	hydrophobic ligand binding site; other site
1097668015038	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668015039	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668015040	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668015041	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668015042	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
1097668015043	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668015044	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668015045	substrate binding site [chemical binding]; other site
1097668015046	oxyanion hole (OAH) forming residues; other site
1097668015047	trimer interface [polypeptide binding]; other site
1097668015048	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1097668015049	CoA binding domain; Region: CoA_binding_2; pfam13380
1097668015050	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1097668015051	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1097668015052	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668015053	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668015054	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1097668015055	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1097668015056	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1097668015057	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1097668015058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668015059	non-specific DNA binding site [nucleotide binding]; other site
1097668015060	salt bridge; other site
1097668015061	sequence-specific DNA binding site [nucleotide binding]; other site
1097668015062	Cupin domain; Region: Cupin_2; pfam07883
1097668015063	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668015064	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015065	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668015066	dimerization interface [polypeptide binding]; other site
1097668015067	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
1097668015068	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1097668015069	NAD(P) binding site [chemical binding]; other site
1097668015070	catalytic residues [active]
1097668015071	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668015072	hypothetical protein; Provisional; Region: PRK11622
1097668015073	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668015074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668015075	dimer interface [polypeptide binding]; other site
1097668015076	putative PBP binding loops; other site
1097668015077	ABC-ATPase subunit interface; other site
1097668015078	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668015079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668015080	dimer interface [polypeptide binding]; other site
1097668015081	conserved gate region; other site
1097668015082	putative PBP binding loops; other site
1097668015083	ABC-ATPase subunit interface; other site
1097668015084	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1097668015085	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668015086	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668015087	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668015088	Walker A/P-loop; other site
1097668015089	ATP binding site [chemical binding]; other site
1097668015090	Q-loop/lid; other site
1097668015091	ABC transporter signature motif; other site
1097668015092	Walker B; other site
1097668015093	D-loop; other site
1097668015094	H-loop/switch region; other site
1097668015095	TOBE domain; Region: TOBE_2; pfam08402
1097668015096	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1097668015097	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668015098	acyl-activating enzyme (AAE) consensus motif; other site
1097668015099	AMP binding site [chemical binding]; other site
1097668015100	active site
1097668015101	CoA binding site [chemical binding]; other site
1097668015102	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1097668015103	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
1097668015104	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668015105	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668015106	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668015107	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668015108	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097668015109	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
1097668015110	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1097668015111	TrkA-C domain; Region: TrkA_C; pfam02080
1097668015112	TrkA-C domain; Region: TrkA_C; pfam02080
1097668015113	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668015114	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
1097668015115	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668015116	TrkA-C domain; Region: TrkA_C; pfam02080
1097668015117	TrkA-C domain; Region: TrkA_C; pfam02080
1097668015118	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668015119	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
1097668015120	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668015121	TrkA-C domain; Region: TrkA_C; pfam02080
1097668015122	TrkA-C domain; Region: TrkA_C; pfam02080
1097668015123	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668015124	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
1097668015125	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668015126	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015127	homodimer interface [polypeptide binding]; other site
1097668015128	catalytic residue [active]
1097668015129	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097668015130	L-tyrosine decarboxylase; Provisional; Region: PRK13520
1097668015131	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668015132	catalytic residue [active]
1097668015133	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668015134	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
1097668015135	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1097668015136	RNA polymerase sigma factor; Provisional; Region: PRK12514
1097668015137	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668015138	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668015139	DNA binding residues [nucleotide binding]
1097668015140	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668015141	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668015142	conserved cys residue [active]
1097668015143	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668015144	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1097668015145	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1097668015146	putative active site [active]
1097668015147	catalytic triad [active]
1097668015148	putative dimer interface [polypeptide binding]; other site
1097668015149	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1097668015150	active site clefts [active]
1097668015151	zinc binding site [ion binding]; other site
1097668015152	dimer interface [polypeptide binding]; other site
1097668015153	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668015154	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1097668015155	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668015156	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668015157	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668015158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015159	putative substrate translocation pore; other site
1097668015160	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1097668015161	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668015162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015163	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1097668015164	putative effector binding pocket; other site
1097668015165	putative dimerization interface [polypeptide binding]; other site
1097668015166	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
1097668015167	active site
1097668015168	SUMO-1 interface [polypeptide binding]; other site
1097668015169	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668015170	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668015171	conserved cys residue [active]
1097668015172	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668015173	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668015174	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1097668015175	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1097668015176	TPP-binding site [chemical binding]; other site
1097668015177	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1097668015178	dimer interface [polypeptide binding]; other site
1097668015179	PYR/PP interface [polypeptide binding]; other site
1097668015180	TPP binding site [chemical binding]; other site
1097668015181	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1097668015182	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668015183	PYR/PP interface [polypeptide binding]; other site
1097668015184	dimer interface [polypeptide binding]; other site
1097668015185	TPP binding site [chemical binding]; other site
1097668015186	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668015187	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1097668015188	TPP-binding site [chemical binding]; other site
1097668015189	dimer interface [polypeptide binding]; other site
1097668015190	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668015191	dimerization interface [polypeptide binding]; other site
1097668015192	putative DNA binding site [nucleotide binding]; other site
1097668015193	putative Zn2+ binding site [ion binding]; other site
1097668015194	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1097668015195	active site
1097668015196	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1097668015197	dimer interface [polypeptide binding]; other site
1097668015198	non-prolyl cis peptide bond; other site
1097668015199	insertion regions; other site
1097668015200	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1097668015201	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1097668015202	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668015203	active site
1097668015204	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1097668015205	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668015206	substrate binding pocket [chemical binding]; other site
1097668015207	membrane-bound complex binding site; other site
1097668015208	hinge residues; other site
1097668015209	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1097668015210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668015211	Walker A/P-loop; other site
1097668015212	ATP binding site [chemical binding]; other site
1097668015213	Q-loop/lid; other site
1097668015214	ABC transporter signature motif; other site
1097668015215	Walker B; other site
1097668015216	D-loop; other site
1097668015217	H-loop/switch region; other site
1097668015218	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668015219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668015220	dimer interface [polypeptide binding]; other site
1097668015221	conserved gate region; other site
1097668015222	ABC-ATPase subunit interface; other site
1097668015223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015224	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668015225	putative substrate translocation pore; other site
1097668015226	Cupin domain; Region: Cupin_2; pfam07883
1097668015227	short chain dehydrogenase; Provisional; Region: PRK06500
1097668015228	classical (c) SDRs; Region: SDR_c; cd05233
1097668015229	NAD(P) binding site [chemical binding]; other site
1097668015230	active site
1097668015231	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1097668015232	active site
1097668015233	phosphorylation site [posttranslational modification]
1097668015234	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
1097668015235	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015236	putative substrate translocation pore; other site
1097668015237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015238	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1097668015239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1097668015240	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668015241	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097668015242	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668015243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668015244	dimer interface [polypeptide binding]; other site
1097668015245	phosphorylation site [posttranslational modification]
1097668015246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668015247	ATP binding site [chemical binding]; other site
1097668015248	Mg2+ binding site [ion binding]; other site
1097668015249	G-X-G motif; other site
1097668015250	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668015251	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
1097668015252	DNA binding residues [nucleotide binding]
1097668015253	dimerization interface [polypeptide binding]; other site
1097668015254	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
1097668015255	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
1097668015256	Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834
1097668015257	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1097668015258	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668015259	ATP binding site [chemical binding]; other site
1097668015260	putative Mg++ binding site [ion binding]; other site
1097668015261	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668015262	nucleotide binding region [chemical binding]; other site
1097668015263	ATP-binding site [chemical binding]; other site
1097668015264	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1097668015265	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668015266	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668015267	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1097668015268	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1097668015269	Active site serine [active]
1097668015270	Amidohydrolase; Region: Amidohydro_5; pfam13594
1097668015271	Amidohydrolase; Region: Amidohydro_4; pfam13147
1097668015272	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668015273	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1097668015274	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1097668015275	putative ion selectivity filter; other site
1097668015276	putative pore gating glutamate residue; other site
1097668015277	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1097668015278	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668015279	dimer interface [polypeptide binding]; other site
1097668015280	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1097668015281	putative CheW interface [polypeptide binding]; other site
1097668015282	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668015283	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097668015284	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668015285	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668015286	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668015287	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668015288	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668015289	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668015290	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668015291	putative phosphoketolase; Provisional; Region: PRK05261
1097668015292	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1097668015293	TPP-binding site; other site
1097668015294	XFP C-terminal domain; Region: XFP_C; pfam09363
1097668015295	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668015296	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668015297	trimer interface [polypeptide binding]; other site
1097668015298	eyelet of channel; other site
1097668015299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015300	putative substrate translocation pore; other site
1097668015301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015302	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1097668015303	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1097668015304	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1097668015305	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1097668015306	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1097668015307	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1097668015308	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668015309	N-terminal plug; other site
1097668015310	ligand-binding site [chemical binding]; other site
1097668015311	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1097668015312	Class II fumarases; Region: Fumarase_classII; cd01362
1097668015313	active site
1097668015314	tetramer interface [polypeptide binding]; other site
1097668015315	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1097668015316	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1097668015317	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1097668015318	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1097668015319	tetramer interface [polypeptide binding]; other site
1097668015320	active site
1097668015321	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097668015322	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668015323	DNA-binding site [nucleotide binding]; DNA binding site
1097668015324	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1097668015325	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668015326	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1097668015327	NAD(P) binding site [chemical binding]; other site
1097668015328	catalytic residues [active]
1097668015329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015330	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1097668015331	putative substrate translocation pore; other site
1097668015332	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668015333	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668015334	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668015335	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668015336	inhibitor site; inhibition site
1097668015337	active site
1097668015338	dimer interface [polypeptide binding]; other site
1097668015339	catalytic residue [active]
1097668015340	hypothetical protein; Validated; Region: PRK06201
1097668015341	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
1097668015342	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668015343	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668015344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015345	putative substrate translocation pore; other site
1097668015346	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668015347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015348	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1097668015349	dimerization interface [polypeptide binding]; other site
1097668015350	substrate binding pocket [chemical binding]; other site
1097668015351	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
1097668015352	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1097668015353	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1097668015354	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668015355	ligand binding site [chemical binding]; other site
1097668015356	flexible hinge region; other site
1097668015357	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097668015358	non-specific DNA interactions [nucleotide binding]; other site
1097668015359	DNA binding site [nucleotide binding]
1097668015360	sequence specific DNA binding site [nucleotide binding]; other site
1097668015361	putative cAMP binding site [chemical binding]; other site
1097668015362	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668015363	Ligand Binding Site [chemical binding]; other site
1097668015364	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015365	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668015366	putative substrate translocation pore; other site
1097668015367	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1097668015368	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1097668015369	dimer interface [polypeptide binding]; other site
1097668015370	NADP binding site [chemical binding]; other site
1097668015371	catalytic residues [active]
1097668015372	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668015373	non-specific DNA binding site [nucleotide binding]; other site
1097668015374	salt bridge; other site
1097668015375	sequence-specific DNA binding site [nucleotide binding]; other site
1097668015376	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1097668015377	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1097668015378	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1097668015379	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1097668015380	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1097668015381	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668015382	Coenzyme A binding pocket [chemical binding]; other site
1097668015383	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1097668015384	putative NAD(P) binding site [chemical binding]; other site
1097668015385	homodimer interface [polypeptide binding]; other site
1097668015386	Protein of unknown function (DUF3005); Region: DUF3005; pfam11448
1097668015387	Transcriptional activator HlyU; Region: HlyU; cl02273
1097668015388	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1097668015389	serine O-acetyltransferase; Region: cysE; TIGR01172
1097668015390	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1097668015391	trimer interface [polypeptide binding]; other site
1097668015392	active site
1097668015393	substrate binding site [chemical binding]; other site
1097668015394	CoA binding site [chemical binding]; other site
1097668015395	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1097668015396	GTP cyclohydrolase I; Provisional; Region: PLN03044
1097668015397	active site
1097668015398	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1097668015399	dimer interface [polypeptide binding]; other site
1097668015400	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668015401	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1097668015402	SnoaL-like domain; Region: SnoaL_3; pfam13474
1097668015403	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668015404	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668015405	WHG domain; Region: WHG; pfam13305
1097668015406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015407	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668015408	putative substrate translocation pore; other site
1097668015409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015410	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1097668015411	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
1097668015412	putative ligand binding site [chemical binding]; other site
1097668015413	NAD binding site [chemical binding]; other site
1097668015414	catalytic site [active]
1097668015415	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1097668015416	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015417	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447
1097668015418	putative dimerization interface [polypeptide binding]; other site
1097668015419	putative substrate binding pocket [chemical binding]; other site
1097668015420	putative aminotransferase; Validated; Region: PRK07480
1097668015421	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668015422	inhibitor-cofactor binding pocket; inhibition site
1097668015423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015424	catalytic residue [active]
1097668015425	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1097668015426	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1097668015427	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1097668015428	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668015429	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668015430	TM-ABC transporter signature motif; other site
1097668015431	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668015432	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668015433	TM-ABC transporter signature motif; other site
1097668015434	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668015435	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668015436	Walker A/P-loop; other site
1097668015437	ATP binding site [chemical binding]; other site
1097668015438	Q-loop/lid; other site
1097668015439	ABC transporter signature motif; other site
1097668015440	Walker B; other site
1097668015441	D-loop; other site
1097668015442	H-loop/switch region; other site
1097668015443	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668015444	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668015445	Walker A/P-loop; other site
1097668015446	ATP binding site [chemical binding]; other site
1097668015447	Q-loop/lid; other site
1097668015448	ABC transporter signature motif; other site
1097668015449	Walker B; other site
1097668015450	D-loop; other site
1097668015451	H-loop/switch region; other site
1097668015452	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668015453	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330
1097668015454	putative ligand binding site [chemical binding]; other site
1097668015455	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1097668015456	active site
1097668015457	DNA binding site [nucleotide binding]
1097668015458	Low affinity iron permease; Region: Iron_permease; pfam04120
1097668015459	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1097668015460	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1097668015461	TadE-like protein; Region: TadE; pfam07811
1097668015462	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1097668015463	TadE-like protein; Region: TadE; pfam07811
1097668015464	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668015465	TPR repeat; Region: TPR_11; pfam13414
1097668015466	binding surface
1097668015467	TPR motif; other site
1097668015468	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668015469	binding surface
1097668015470	TPR motif; other site
1097668015471	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1097668015472	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1097668015473	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668015474	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1097668015475	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668015476	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1097668015477	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1097668015478	ATP binding site [chemical binding]; other site
1097668015479	Walker A motif; other site
1097668015480	hexamer interface [polypeptide binding]; other site
1097668015481	Walker B motif; other site
1097668015482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1097668015483	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668015484	active site
1097668015485	phosphorylation site [posttranslational modification]
1097668015486	intermolecular recognition site; other site
1097668015487	dimerization interface [polypeptide binding]; other site
1097668015488	AAA domain; Region: AAA_31; pfam13614
1097668015489	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1097668015490	Type IV pili component [Cell motility and secretion]; Region: COG5461
1097668015491	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1097668015492	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1097668015493	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1097668015494	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1097668015495	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1097668015496	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1097668015497	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1097668015498	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015499	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668015500	dimerization interface [polypeptide binding]; other site
1097668015501	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
1097668015502	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668015503	substrate binding pocket [chemical binding]; other site
1097668015504	membrane-bound complex binding site; other site
1097668015505	hinge residues; other site
1097668015506	Predicted deacylase [General function prediction only]; Region: COG3608
1097668015507	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1097668015508	active site
1097668015509	Zn binding site [ion binding]; other site
1097668015510	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668015511	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1097668015512	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097668015513	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097668015514	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1097668015515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668015516	Walker A/P-loop; other site
1097668015517	ATP binding site [chemical binding]; other site
1097668015518	Q-loop/lid; other site
1097668015519	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097668015520	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1097668015521	ACT domain; Region: ACT_3; pfam10000
1097668015522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602
1097668015523	Family description; Region: ACT_7; pfam13840
1097668015524	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1097668015525	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
1097668015526	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
1097668015527	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1097668015528	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
1097668015529	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1097668015530	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1097668015531	putative molybdopterin cofactor binding site [chemical binding]; other site
1097668015532	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1097668015533	putative molybdopterin cofactor binding site; other site
1097668015534	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668015535	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668015536	DNA-binding site [nucleotide binding]; DNA binding site
1097668015537	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668015538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015539	homodimer interface [polypeptide binding]; other site
1097668015540	catalytic residue [active]
1097668015541	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668015542	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668015543	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1097668015544	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1097668015545	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1097668015546	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
1097668015547	dimer interface [polypeptide binding]; other site
1097668015548	NADP binding site [chemical binding]; other site
1097668015549	catalytic residues [active]
1097668015550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668015551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015552	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1097668015553	putative dimerization interface [polypeptide binding]; other site
1097668015554	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1097668015555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668015556	S-adenosylmethionine binding site [chemical binding]; other site
1097668015557	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668015558	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1097668015559	dimer interface [polypeptide binding]; other site
1097668015560	phosphorylation site [posttranslational modification]
1097668015561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668015562	ATP binding site [chemical binding]; other site
1097668015563	Mg2+ binding site [ion binding]; other site
1097668015564	G-X-G motif; other site
1097668015565	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1097668015566	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1097668015567	catalytic residue [active]
1097668015568	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1097668015569	catalytic residues [active]
1097668015570	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668015571	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668015572	peroxiredoxin; Region: AhpC; TIGR03137
1097668015573	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1097668015574	dimer interface [polypeptide binding]; other site
1097668015575	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1097668015576	catalytic triad [active]
1097668015577	peroxidatic and resolving cysteines [active]
1097668015578	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1097668015579	dimerization interface [polypeptide binding]; other site
1097668015580	active site
1097668015581	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
1097668015582	Hemerythrin-like domain; Region: Hr-like; cd12108
1097668015583	Fe binding site [ion binding]; other site
1097668015584	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1097668015585	DEAD_2; Region: DEAD_2; pfam06733
1097668015586	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1097668015587	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668015588	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668015589	DNA-binding site [nucleotide binding]; DNA binding site
1097668015590	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668015591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015592	homodimer interface [polypeptide binding]; other site
1097668015593	catalytic residue [active]
1097668015594	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668015595	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668015596	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
1097668015597	Phasin protein; Region: Phasin_2; pfam09361
1097668015598	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097668015599	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1097668015600	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1097668015601	putative chaperone protein EcpD; Provisional; Region: PRK09926
1097668015602	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1097668015603	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1097668015604	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1097668015605	PapC N-terminal domain; Region: PapC_N; pfam13954
1097668015606	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1097668015607	PapC C-terminal domain; Region: PapC_C; pfam13953
1097668015608	Fimbrial protein; Region: Fimbrial; pfam00419
1097668015609	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1097668015610	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097668015611	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668015612	protein binding site [polypeptide binding]; other site
1097668015613	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
1097668015614	ATP adenylyltransferase; Region: ATP_transf; pfam09830
1097668015615	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668015616	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
1097668015617	putative active site pocket [active]
1097668015618	metal binding site [ion binding]; metal-binding site
1097668015619	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668015620	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1097668015621	DNA-binding site [nucleotide binding]; DNA binding site
1097668015622	FCD domain; Region: FCD; pfam07729
1097668015623	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1097668015624	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097668015625	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1097668015626	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668015627	dimer interface [polypeptide binding]; other site
1097668015628	conserved gate region; other site
1097668015629	putative PBP binding loops; other site
1097668015630	ABC-ATPase subunit interface; other site
1097668015631	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097668015632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097668015633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668015634	dimer interface [polypeptide binding]; other site
1097668015635	conserved gate region; other site
1097668015636	putative PBP binding loops; other site
1097668015637	ABC-ATPase subunit interface; other site
1097668015638	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1097668015639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668015640	Walker A/P-loop; other site
1097668015641	ATP binding site [chemical binding]; other site
1097668015642	Q-loop/lid; other site
1097668015643	ABC transporter signature motif; other site
1097668015644	Walker B; other site
1097668015645	D-loop; other site
1097668015646	H-loop/switch region; other site
1097668015647	TOBE domain; Region: TOBE_2; pfam08402
1097668015648	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1097668015649	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668015650	P-loop; other site
1097668015651	Magnesium ion binding site [ion binding]; other site
1097668015652	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668015653	Magnesium ion binding site [ion binding]; other site
1097668015654	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668015655	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015656	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668015657	dimerization interface [polypeptide binding]; other site
1097668015658	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
1097668015659	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668015660	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668015661	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668015662	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668015663	putative DNA binding site [nucleotide binding]; other site
1097668015664	putative Zn2+ binding site [ion binding]; other site
1097668015665	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668015666	2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012
1097668015667	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1097668015668	dimer interface [polypeptide binding]; other site
1097668015669	TPP-binding site [chemical binding]; other site
1097668015670	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
1097668015671	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668015672	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668015673	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668015674	substrate binding site [chemical binding]; other site
1097668015675	oxyanion hole (OAH) forming residues; other site
1097668015676	trimer interface [polypeptide binding]; other site
1097668015677	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1097668015678	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1097668015679	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1097668015680	homodimer interface [polypeptide binding]; other site
1097668015681	NAD binding pocket [chemical binding]; other site
1097668015682	ATP binding pocket [chemical binding]; other site
1097668015683	Mg binding site [ion binding]; other site
1097668015684	active-site loop [active]
1097668015685	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1097668015686	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1097668015687	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
1097668015688	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1097668015689	Fe-S cluster binding site [ion binding]; other site
1097668015690	active site
1097668015691	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1097668015692	iron-sulfur cluster [ion binding]; other site
1097668015693	[2Fe-2S] cluster binding site [ion binding]; other site
1097668015694	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1097668015695	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668015696	Lysozyme family protein [General function prediction only]; Region: COG5526
1097668015697	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
1097668015698	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668015699	Walker A/P-loop; other site
1097668015700	ATP binding site [chemical binding]; other site
1097668015701	Q-loop/lid; other site
1097668015702	ABC transporter signature motif; other site
1097668015703	Walker B; other site
1097668015704	D-loop; other site
1097668015705	H-loop/switch region; other site
1097668015706	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668015707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668015708	dimer interface [polypeptide binding]; other site
1097668015709	conserved gate region; other site
1097668015710	putative PBP binding loops; other site
1097668015711	ABC-ATPase subunit interface; other site
1097668015712	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668015713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668015714	dimer interface [polypeptide binding]; other site
1097668015715	conserved gate region; other site
1097668015716	putative PBP binding loops; other site
1097668015717	ABC-ATPase subunit interface; other site
1097668015718	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
1097668015719	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668015720	substrate binding pocket [chemical binding]; other site
1097668015721	membrane-bound complex binding site; other site
1097668015722	hinge residues; other site
1097668015723	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668015724	DNA-binding site [nucleotide binding]; DNA binding site
1097668015725	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668015726	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668015727	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015728	homodimer interface [polypeptide binding]; other site
1097668015729	catalytic residue [active]
1097668015730	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1097668015731	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1097668015732	tetramer interface [polypeptide binding]; other site
1097668015733	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015734	catalytic residue [active]
1097668015735	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1097668015736	ectoine utilization protein EutC; Validated; Region: PRK08291
1097668015737	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
1097668015738	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1097668015739	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1097668015740	active site
1097668015741	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
1097668015742	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
1097668015743	putative active site [active]
1097668015744	Zn binding site [ion binding]; other site
1097668015745	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668015746	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668015747	putative DNA binding site [nucleotide binding]; other site
1097668015748	putative Zn2+ binding site [ion binding]; other site
1097668015749	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668015750	succinic semialdehyde dehydrogenase; Region: PLN02278
1097668015751	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668015752	tetramerization interface [polypeptide binding]; other site
1097668015753	NAD(P) binding site [chemical binding]; other site
1097668015754	catalytic residues [active]
1097668015755	hypothetical protein; Provisional; Region: PRK07482
1097668015756	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668015757	inhibitor-cofactor binding pocket; inhibition site
1097668015758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668015759	catalytic residue [active]
1097668015760	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1097668015761	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097668015762	GAF domain; Region: GAF; pfam01590
1097668015763	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668015764	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668015765	metal binding site [ion binding]; metal-binding site
1097668015766	active site
1097668015767	I-site; other site
1097668015768	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668015769	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668015770	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668015771	conserved cys residue [active]
1097668015772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668015773	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668015774	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1097668015775	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1097668015776	conserved cys residue [active]
1097668015777	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097668015778	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1097668015779	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668015780	substrate binding pocket [chemical binding]; other site
1097668015781	membrane-bound complex binding site; other site
1097668015782	hinge residues; other site
1097668015783	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1097668015784	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668015785	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668015786	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668015787	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
1097668015788	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668015789	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
1097668015790	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1097668015791	Walker A motif; other site
1097668015792	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1097668015793	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1097668015794	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1097668015795	active site
1097668015796	dimer interface [polypeptide binding]; other site
1097668015797	effector binding site; other site
1097668015798	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668015799	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097668015800	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668015801	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015802	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1097668015803	putative effector binding pocket; other site
1097668015804	putative dimerization interface [polypeptide binding]; other site
1097668015805	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668015806	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668015807	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668015808	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668015809	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668015810	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097668015811	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668015812	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1097668015813	ornithine cyclodeaminase; Validated; Region: PRK07340
1097668015814	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1097668015815	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1097668015816	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
1097668015817	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097668015818	catalytic core [active]
1097668015819	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
1097668015820	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
1097668015821	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1097668015822	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1097668015823	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668015824	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1097668015825	catalytic triad [active]
1097668015826	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1097668015827	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1097668015828	homodimer interface [polypeptide binding]; other site
1097668015829	Walker A motif; other site
1097668015830	ATP binding site [chemical binding]; other site
1097668015831	hydroxycobalamin binding site [chemical binding]; other site
1097668015832	Walker B motif; other site
1097668015833	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1097668015834	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1097668015835	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1097668015836	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1097668015837	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1097668015838	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1097668015839	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1097668015840	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
1097668015841	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668015842	Walker A motif; other site
1097668015843	ATP binding site [chemical binding]; other site
1097668015844	Walker B motif; other site
1097668015845	arginine finger; other site
1097668015846	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1097668015847	metal ion-dependent adhesion site (MIDAS); other site
1097668015848	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
1097668015849	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1097668015850	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1097668015851	active site
1097668015852	SAM binding site [chemical binding]; other site
1097668015853	homodimer interface [polypeptide binding]; other site
1097668015854	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1097668015855	active site
1097668015856	SAM binding site [chemical binding]; other site
1097668015857	homodimer interface [polypeptide binding]; other site
1097668015858	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1097668015859	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1097668015860	precorrin-3B synthase; Region: CobG; TIGR02435
1097668015861	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1097668015862	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1097668015863	active site
1097668015864	putative homodimer interface [polypeptide binding]; other site
1097668015865	SAM binding site [chemical binding]; other site
1097668015866	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1097668015867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668015868	S-adenosylmethionine binding site [chemical binding]; other site
1097668015869	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1097668015870	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
1097668015871	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1097668015872	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1097668015873	active site
1097668015874	SAM binding site [chemical binding]; other site
1097668015875	homodimer interface [polypeptide binding]; other site
1097668015876	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
1097668015877	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1097668015878	OpgC protein; Region: OpgC_C; pfam10129
1097668015879	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1097668015880	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1097668015881	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1097668015882	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1097668015883	GAF domain; Region: GAF; pfam01590
1097668015884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668015885	Walker A motif; other site
1097668015886	ATP binding site [chemical binding]; other site
1097668015887	Walker B motif; other site
1097668015888	arginine finger; other site
1097668015889	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668015890	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1097668015891	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1097668015892	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1097668015893	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1097668015894	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1097668015895	active site residue [active]
1097668015896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668015897	Walker A/P-loop; other site
1097668015898	ATP binding site [chemical binding]; other site
1097668015899	Predicted permease; Region: DUF318; cl17795
1097668015900	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1097668015901	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1097668015902	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1097668015903	Predicted metalloprotease [General function prediction only]; Region: COG2321
1097668015904	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1097668015905	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1097668015906	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1097668015907	putative active site [active]
1097668015908	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1097668015909	PilZ domain; Region: PilZ; pfam07238
1097668015910	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1097668015911	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1097668015912	catalytic residues [active]
1097668015913	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668015914	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
1097668015915	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668015916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015917	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1097668015918	putative dimerization interface [polypeptide binding]; other site
1097668015919	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668015920	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668015921	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668015922	classical (c) SDRs; Region: SDR_c; cd05233
1097668015923	NAD(P) binding site [chemical binding]; other site
1097668015924	active site
1097668015925	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668015926	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668015927	putative substrate translocation pore; other site
1097668015928	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097668015929	GAF domain; Region: GAF; pfam01590
1097668015930	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668015931	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668015932	metal binding site [ion binding]; metal-binding site
1097668015933	active site
1097668015934	I-site; other site
1097668015935	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
1097668015936	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668015937	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668015938	substrate binding pocket [chemical binding]; other site
1097668015939	membrane-bound complex binding site; other site
1097668015940	hinge residues; other site
1097668015941	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1097668015942	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1097668015943	active site
1097668015944	Zn binding site [ion binding]; other site
1097668015945	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
1097668015946	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668015947	dimerization interface [polypeptide binding]; other site
1097668015948	putative DNA binding site [nucleotide binding]; other site
1097668015949	putative Zn2+ binding site [ion binding]; other site
1097668015950	Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003
1097668015951	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1097668015952	Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome.  They belong to the superfamily...; Region: INT_Lambda_C; cd00800
1097668015953	dimer interface [polypeptide binding]; other site
1097668015954	active site
1097668015955	Int/Topo IB signature motif; other site
1097668015956	RecT family; Region: RecT; cl04285
1097668015957	HNH endonuclease; Region: HNH_3; pfam13392
1097668015958	exonuclease VIII; Reviewed; Region: PRK09709
1097668015959	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668015960	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668015961	non-specific DNA binding site [nucleotide binding]; other site
1097668015962	salt bridge; other site
1097668015963	sequence-specific DNA binding site [nucleotide binding]; other site
1097668015964	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1097668015965	Catalytic site [active]
1097668015966	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
1097668015967	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
1097668015968	Protein of unknown function (DUF1376); Region: DUF1376; pfam07120
1097668015969	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
1097668015970	hypothetical protein; Region: PHA00670
1097668015971	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
1097668015972	putative protease; Region: PHA00666
1097668015973	hypothetical protein; Region: PHA00662
1097668015974	hypothetical protein; Region: PHA00661
1097668015975	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097668015976	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668015977	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668015978	structural protein; Region: PHA01972
1097668015979	Right handed beta helix region; Region: Beta_helix; pfam13229
1097668015980	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1097668015981	catalytic residue [active]
1097668015982	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1097668015983	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
1097668015984	putative hydrophobic ligand binding site [chemical binding]; other site
1097668015985	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1097668015986	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1097668015987	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1097668015988	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668015989	classical (c) SDRs; Region: SDR_c; cd05233
1097668015990	NAD(P) binding site [chemical binding]; other site
1097668015991	active site
1097668015992	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1097668015993	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668015994	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668015995	dimerization interface [polypeptide binding]; other site
1097668015996	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1097668015997	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1097668015998	peptide binding site [polypeptide binding]; other site
1097668015999	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1097668016000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668016001	dimer interface [polypeptide binding]; other site
1097668016002	conserved gate region; other site
1097668016003	putative PBP binding loops; other site
1097668016004	ABC-ATPase subunit interface; other site
1097668016005	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1097668016006	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1097668016007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668016008	dimer interface [polypeptide binding]; other site
1097668016009	conserved gate region; other site
1097668016010	putative PBP binding loops; other site
1097668016011	ABC-ATPase subunit interface; other site
1097668016012	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1097668016013	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668016014	Walker A/P-loop; other site
1097668016015	ATP binding site [chemical binding]; other site
1097668016016	Q-loop/lid; other site
1097668016017	ABC transporter signature motif; other site
1097668016018	Walker B; other site
1097668016019	D-loop; other site
1097668016020	H-loop/switch region; other site
1097668016021	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668016022	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1097668016023	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668016024	Walker A/P-loop; other site
1097668016025	ATP binding site [chemical binding]; other site
1097668016026	Q-loop/lid; other site
1097668016027	ABC transporter signature motif; other site
1097668016028	Walker B; other site
1097668016029	D-loop; other site
1097668016030	H-loop/switch region; other site
1097668016031	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668016032	outer membrane porin, OprD family; Region: OprD; pfam03573
1097668016033	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1097668016034	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016035	putative substrate translocation pore; other site
1097668016036	NnrS protein; Region: NnrS; pfam05940
1097668016037	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1097668016038	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1097668016039	heme-binding site [chemical binding]; other site
1097668016040	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1097668016041	FAD binding pocket [chemical binding]; other site
1097668016042	FAD binding motif [chemical binding]; other site
1097668016043	phosphate binding motif [ion binding]; other site
1097668016044	beta-alpha-beta structure motif; other site
1097668016045	NAD binding pocket [chemical binding]; other site
1097668016046	Heme binding  pocket [chemical binding]; other site
1097668016047	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1097668016048	GAF domain; Region: GAF; pfam01590
1097668016049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668016050	Walker A motif; other site
1097668016051	ATP binding site [chemical binding]; other site
1097668016052	Walker B motif; other site
1097668016053	arginine finger; other site
1097668016054	Cytochrome c; Region: Cytochrom_C; cl11414
1097668016055	Cytochrome c; Region: Cytochrom_C; cl11414
1097668016056	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668016057	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668016058	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668016059	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668016060	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1097668016061	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1097668016062	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1097668016063	D-pathway; other site
1097668016064	Low-spin heme binding site [chemical binding]; other site
1097668016065	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1097668016066	Putative water exit pathway; other site
1097668016067	Binuclear center (active site) [active]
1097668016068	K-pathway; other site
1097668016069	Putative proton exit pathway; other site
1097668016070	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1097668016071	Cytochrome c; Region: Cytochrom_C; cl11414
1097668016072	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097668016073	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668016074	Coenzyme A binding pocket [chemical binding]; other site
1097668016075	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1097668016076	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668016077	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668016078	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1097668016079	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1097668016080	Zn2+ binding site [ion binding]; other site
1097668016081	Mg2+ binding site [ion binding]; other site
1097668016082	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668016083	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668016084	conserved cys residue [active]
1097668016085	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668016086	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1097668016087	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1097668016088	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097668016089	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1097668016090	putative NAD(P) binding site [chemical binding]; other site
1097668016091	catalytic Zn binding site [ion binding]; other site
1097668016092	structural Zn binding site [ion binding]; other site
1097668016093	NAD-dependent deacetylase; Provisional; Region: PRK05333
1097668016094	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1097668016095	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1097668016096	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1097668016097	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668016098	catalytic residue [active]
1097668016099	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1097668016100	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668016101	dimerization interface [polypeptide binding]; other site
1097668016102	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1097668016103	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668016104	dimer interface [polypeptide binding]; other site
1097668016105	putative CheW interface [polypeptide binding]; other site
1097668016106	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1097668016107	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1097668016108	NADP binding site [chemical binding]; other site
1097668016109	dimer interface [polypeptide binding]; other site
1097668016110	PRC-barrel domain; Region: PRC; pfam05239
1097668016111	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
1097668016112	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
1097668016113	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668016114	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668016115	active site
1097668016116	catalytic tetrad [active]
1097668016117	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668016118	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668016119	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668016120	putative active site [active]
1097668016121	catalytic site [active]
1097668016122	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668016123	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
1097668016124	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668016125	putative active site [active]
1097668016126	catalytic site [active]
1097668016127	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1097668016128	Sel1-like repeats; Region: SEL1; smart00671
1097668016129	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1097668016130	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1097668016131	Cl- selectivity filter; other site
1097668016132	Cl- binding residues [ion binding]; other site
1097668016133	pore gating glutamate residue; other site
1097668016134	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668016135	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1097668016136	MarR family; Region: MarR_2; pfam12802
1097668016137	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
1097668016138	HPP family; Region: HPP; pfam04982
1097668016139	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1097668016140	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
1097668016141	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
1097668016142	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668016143	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097668016144	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1097668016145	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1097668016146	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1097668016147	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1097668016148	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668016149	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1097668016150	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1097668016151	phosphopeptide binding site; other site
1097668016152	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1097668016153	phosphopeptide binding site; other site
1097668016154	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1097668016155	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1097668016156	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668016157	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668016158	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1097668016159	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1097668016160	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668016161	bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896
1097668016162	ligand binding site [chemical binding]; other site
1097668016163	flexible hinge region; other site
1097668016164	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668016165	ligand binding site [chemical binding]; other site
1097668016166	flexible hinge region; other site
1097668016167	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1097668016168	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1097668016169	putative active site [active]
1097668016170	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097668016171	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668016172	Walker A/P-loop; other site
1097668016173	ATP binding site [chemical binding]; other site
1097668016174	Q-loop/lid; other site
1097668016175	ABC transporter signature motif; other site
1097668016176	Walker B; other site
1097668016177	D-loop; other site
1097668016178	H-loop/switch region; other site
1097668016179	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1097668016180	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668016181	Walker A motif; other site
1097668016182	ATP binding site [chemical binding]; other site
1097668016183	Walker B motif; other site
1097668016184	arginine finger; other site
1097668016185	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1097668016186	Protein phosphatase 2C; Region: PP2C; pfam00481
1097668016187	active site
1097668016188	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1097668016189	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1097668016190	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1097668016191	dimer interface [polypeptide binding]; other site
1097668016192	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1097668016193	active site
1097668016194	Fe binding site [ion binding]; other site
1097668016195	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1097668016196	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1097668016197	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668016198	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097668016199	active site
1097668016200	metal binding site [ion binding]; metal-binding site
1097668016201	RNA polymerase sigma factor; Provisional; Region: PRK12533
1097668016202	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668016203	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668016204	DNA binding residues [nucleotide binding]
1097668016205	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1097668016206	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668016207	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
1097668016208	putative ligand binding site [chemical binding]; other site
1097668016209	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668016210	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668016211	TM-ABC transporter signature motif; other site
1097668016212	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668016213	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668016214	TM-ABC transporter signature motif; other site
1097668016215	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668016216	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668016217	Walker A/P-loop; other site
1097668016218	ATP binding site [chemical binding]; other site
1097668016219	Q-loop/lid; other site
1097668016220	ABC transporter signature motif; other site
1097668016221	Walker B; other site
1097668016222	D-loop; other site
1097668016223	H-loop/switch region; other site
1097668016224	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668016225	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668016226	Walker A/P-loop; other site
1097668016227	ATP binding site [chemical binding]; other site
1097668016228	Q-loop/lid; other site
1097668016229	ABC transporter signature motif; other site
1097668016230	Walker B; other site
1097668016231	D-loop; other site
1097668016232	H-loop/switch region; other site
1097668016233	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
1097668016234	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668016235	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668016236	shikimate binding site; other site
1097668016237	NAD(P) binding site [chemical binding]; other site
1097668016238	K+ potassium transporter; Region: K_trans; pfam02705
1097668016239	K+ potassium transporter; Region: K_trans; cl15781
1097668016240	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1097668016241	Coenzyme A transferase; Region: CoA_trans; smart00882
1097668016242	Coenzyme A transferase; Region: CoA_trans; cl17247
1097668016243	amino acid transporter; Region: 2A0306; TIGR00909
1097668016244	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1097668016245	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1097668016246	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1097668016247	dimer interface [polypeptide binding]; other site
1097668016248	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1097668016249	catalytic triad [active]
1097668016250	Ferritin-like domain; Region: Ferritin; pfam00210
1097668016251	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1097668016252	dinuclear metal binding motif [ion binding]; other site
1097668016253	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668016254	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668016255	DNA-binding site [nucleotide binding]; DNA binding site
1097668016256	FCD domain; Region: FCD; pfam07729
1097668016257	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1097668016258	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668016259	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668016260	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668016261	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1097668016262	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1097668016263	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016264	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668016265	dimerization interface [polypeptide binding]; other site
1097668016266	transaminase; Validated; Region: PRK07324
1097668016267	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668016268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668016269	homodimer interface [polypeptide binding]; other site
1097668016270	catalytic residue [active]
1097668016271	methionine sulfoxide reductase A; Provisional; Region: PRK13014
1097668016272	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1097668016273	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1097668016274	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1097668016275	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668016276	catalytic residues [active]
1097668016277	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
1097668016278	SelR domain; Region: SelR; pfam01641
1097668016279	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668016280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016281	active site
1097668016282	phosphorylation site [posttranslational modification]
1097668016283	intermolecular recognition site; other site
1097668016284	dimerization interface [polypeptide binding]; other site
1097668016285	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668016286	DNA binding site [nucleotide binding]
1097668016287	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1097668016288	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1097668016289	dimerization interface [polypeptide binding]; other site
1097668016290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668016291	dimer interface [polypeptide binding]; other site
1097668016292	phosphorylation site [posttranslational modification]
1097668016293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668016294	ATP binding site [chemical binding]; other site
1097668016295	Mg2+ binding site [ion binding]; other site
1097668016296	G-X-G motif; other site
1097668016297	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668016298	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668016299	DNA-binding site [nucleotide binding]; DNA binding site
1097668016300	FCD domain; Region: FCD; pfam07729
1097668016301	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1097668016302	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1097668016303	putative dimer interface [polypeptide binding]; other site
1097668016304	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668016305	ligand binding site [chemical binding]; other site
1097668016306	Zn binding site [ion binding]; other site
1097668016307	H-NS histone family; Region: Histone_HNS; pfam00816
1097668016308	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1097668016309	H-NS histone family; Region: Histone_HNS; pfam00816
1097668016310	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1097668016311	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1097668016312	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1097668016313	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1097668016314	Na binding site [ion binding]; other site
1097668016315	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1097668016316	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1097668016317	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1097668016318	FMN binding site [chemical binding]; other site
1097668016319	substrate binding site [chemical binding]; other site
1097668016320	putative catalytic residue [active]
1097668016321	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668016322	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016323	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1097668016324	putative dimerization interface [polypeptide binding]; other site
1097668016325	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1097668016326	active site
1097668016327	homotetramer interface [polypeptide binding]; other site
1097668016328	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1097668016329	active site
1097668016330	homotetramer interface [polypeptide binding]; other site
1097668016331	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016332	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668016333	putative substrate translocation pore; other site
1097668016334	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668016335	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016336	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668016337	dimerization interface [polypeptide binding]; other site
1097668016338	OHCU decarboxylase; Region: OHCU_decarbox; pfam09349
1097668016339	SnoaL-like domain; Region: SnoaL_3; pfam13474
1097668016340	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1097668016341	Flavin Reductases; Region: FlaRed; cl00801
1097668016342	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1097668016343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016344	active site
1097668016345	phosphorylation site [posttranslational modification]
1097668016346	intermolecular recognition site; other site
1097668016347	dimerization interface [polypeptide binding]; other site
1097668016348	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668016349	DNA binding residues [nucleotide binding]
1097668016350	dimerization interface [polypeptide binding]; other site
1097668016351	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668016352	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
1097668016353	NAD(P) binding site [chemical binding]; other site
1097668016354	active site
1097668016355	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1097668016356	Amidase; Region: Amidase; cl11426
1097668016357	SnoaL-like domain; Region: SnoaL_4; pfam13577
1097668016358	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668016359	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668016360	active site
1097668016361	PAS domain; Region: PAS_9; pfam13426
1097668016362	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1097668016363	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668016364	putative active site [active]
1097668016365	heme pocket [chemical binding]; other site
1097668016366	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668016367	dimer interface [polypeptide binding]; other site
1097668016368	phosphorylation site [posttranslational modification]
1097668016369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668016370	ATP binding site [chemical binding]; other site
1097668016371	Mg2+ binding site [ion binding]; other site
1097668016372	G-X-G motif; other site
1097668016373	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1097668016374	inter-subunit interface; other site
1097668016375	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1097668016376	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668016377	[2Fe-2S] cluster binding site [ion binding]; other site
1097668016378	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1097668016379	putative alpha subunit interface [polypeptide binding]; other site
1097668016380	putative active site [active]
1097668016381	putative substrate binding site [chemical binding]; other site
1097668016382	Fe binding site [ion binding]; other site
1097668016383	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668016384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016385	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668016386	substrate binding pocket [chemical binding]; other site
1097668016387	dimerization interface [polypeptide binding]; other site
1097668016388	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668016389	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668016390	FMN-binding pocket [chemical binding]; other site
1097668016391	flavin binding motif; other site
1097668016392	phosphate binding motif [ion binding]; other site
1097668016393	beta-alpha-beta structure motif; other site
1097668016394	NAD binding pocket [chemical binding]; other site
1097668016395	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668016396	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668016397	catalytic loop [active]
1097668016398	iron binding site [ion binding]; other site
1097668016399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016400	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668016401	putative substrate translocation pore; other site
1097668016402	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668016403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668016404	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
1097668016405	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1097668016406	Methylamine utilisation protein MauE; Region: MauE; pfam07291
1097668016407	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1097668016408	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
1097668016409	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668016410	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668016411	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668016412	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668016413	NAD(P) binding site [chemical binding]; other site
1097668016414	catalytic residues [active]
1097668016415	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668016416	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668016417	trimer interface [polypeptide binding]; other site
1097668016418	eyelet of channel; other site
1097668016419	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1097668016420	nucleoside/Zn binding site; other site
1097668016421	dimer interface [polypeptide binding]; other site
1097668016422	catalytic motif [active]
1097668016423	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668016424	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016425	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668016426	dimerization interface [polypeptide binding]; other site
1097668016427	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668016428	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1097668016429	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668016430	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668016431	NAD(P) binding site [chemical binding]; other site
1097668016432	catalytic residues [active]
1097668016433	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
1097668016434	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668016435	Winged helix-turn helix; Region: HTH_29; pfam13551
1097668016436	Homeodomain-like domain; Region: HTH_32; pfam13565
1097668016437	Integrase core domain; Region: rve; pfam00665
1097668016438	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668016439	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668016440	dimerization interface [polypeptide binding]; other site
1097668016441	ligand binding site [chemical binding]; other site
1097668016442	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1097668016443	phenol 2-monooxygenase; Provisional; Region: PRK08294
1097668016444	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668016445	FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979
1097668016446	dimer interface [polypeptide binding]; other site
1097668016447	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668016448	MarR family; Region: MarR; pfam01047
1097668016449	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
1097668016450	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1097668016451	DAK2 domain; Region: Dak2; cl03685
1097668016452	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1097668016453	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1097668016454	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1097668016455	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1097668016456	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1097668016457	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1097668016458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016459	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668016460	dimerization interface [polypeptide binding]; other site
1097668016461	Protein of unknown function, DUF273; Region: DUF273; pfam03314
1097668016462	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
1097668016463	DNA polymerase II; Reviewed; Region: PRK05762
1097668016464	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1097668016465	active site
1097668016466	catalytic site [active]
1097668016467	substrate binding site [chemical binding]; other site
1097668016468	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1097668016469	active site
1097668016470	metal-binding site
1097668016471	transcriptional activator FlhC; Provisional; Region: PRK12860
1097668016472	transcriptional activator FlhD; Provisional; Region: PRK02909
1097668016473	Purine nucleoside permease (NUP); Region: NUP; pfam06516
1097668016474	putative mechanosensitive channel protein; Provisional; Region: PRK11465
1097668016475	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668016476	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1097668016477	Cation efflux family; Region: Cation_efflux; pfam01545
1097668016478	selenophosphate synthetase; Provisional; Region: PRK00943
1097668016479	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1097668016480	dimerization interface [polypeptide binding]; other site
1097668016481	putative ATP binding site [chemical binding]; other site
1097668016482	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
1097668016483	Predicted transcriptional regulator [Transcription]; Region: COG1959
1097668016484	Transcriptional regulator; Region: Rrf2; pfam02082
1097668016485	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1097668016486	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1097668016487	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1097668016488	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668016489	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668016490	DNA binding residues [nucleotide binding]
1097668016491	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1097668016492	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1097668016493	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1097668016494	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668016495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668016496	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668016497	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668016498	active site
1097668016499	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668016500	catalytic tetrad [active]
1097668016501	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1097668016502	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668016503	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1097668016504	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1097668016505	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1097668016506	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
1097668016507	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
1097668016508	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1097668016509	homotrimer interaction site [polypeptide binding]; other site
1097668016510	putative active site [active]
1097668016511	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668016512	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016513	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668016514	dimerization interface [polypeptide binding]; other site
1097668016515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668016516	NAD(P) binding site [chemical binding]; other site
1097668016517	active site
1097668016518	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668016519	putative dehydrogenase; Provisional; Region: PRK10098
1097668016520	hypothetical protein; Provisional; Region: PRK07907
1097668016521	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682
1097668016522	metal binding site [ion binding]; metal-binding site
1097668016523	putative dimer interface [polypeptide binding]; other site
1097668016524	Penicillin amidase; Region: Penicil_amidase; pfam01804
1097668016525	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1097668016526	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1097668016527	active site
1097668016528	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1097668016529	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
1097668016530	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
1097668016531	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
1097668016532	Predicted integral membrane protein [Function unknown]; Region: COG0392
1097668016533	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1097668016534	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1097668016535	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668016536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016537	active site
1097668016538	phosphorylation site [posttranslational modification]
1097668016539	intermolecular recognition site; other site
1097668016540	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668016541	DNA binding residues [nucleotide binding]
1097668016542	dimerization interface [polypeptide binding]; other site
1097668016543	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668016544	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1097668016545	active site
1097668016546	catalytic residues [active]
1097668016547	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668016548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668016549	dimer interface [polypeptide binding]; other site
1097668016550	conserved gate region; other site
1097668016551	putative PBP binding loops; other site
1097668016552	ABC-ATPase subunit interface; other site
1097668016553	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1097668016554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668016555	dimer interface [polypeptide binding]; other site
1097668016556	conserved gate region; other site
1097668016557	putative PBP binding loops; other site
1097668016558	ABC-ATPase subunit interface; other site
1097668016559	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668016560	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668016561	Walker A/P-loop; other site
1097668016562	ATP binding site [chemical binding]; other site
1097668016563	Q-loop/lid; other site
1097668016564	ABC transporter signature motif; other site
1097668016565	Walker B; other site
1097668016566	D-loop; other site
1097668016567	H-loop/switch region; other site
1097668016568	TOBE domain; Region: TOBE_2; pfam08402
1097668016569	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
1097668016570	hypothetical protein; Provisional; Region: PRK11622
1097668016571	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668016572	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668016573	DNA-binding site [nucleotide binding]; DNA binding site
1097668016574	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668016575	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1097668016576	Protein of unknown function (DUF3303); Region: DUF3303; pfam11746
1097668016577	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1097668016578	pseudo EF-hand loop; other site
1097668016579	peptide binding pocket; other site
1097668016580	Ca2+ binding site [ion binding]; other site
1097668016581	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1097668016582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016583	active site
1097668016584	phosphorylation site [posttranslational modification]
1097668016585	intermolecular recognition site; other site
1097668016586	dimerization interface [polypeptide binding]; other site
1097668016587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668016588	DNA binding site [nucleotide binding]
1097668016589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1097668016590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668016591	dimer interface [polypeptide binding]; other site
1097668016592	phosphorylation site [posttranslational modification]
1097668016593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668016594	ATP binding site [chemical binding]; other site
1097668016595	Mg2+ binding site [ion binding]; other site
1097668016596	G-X-G motif; other site
1097668016597	transcriptional regulator FixK; Provisional; Region: fixK; PRK09391
1097668016598	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668016599	ligand binding site [chemical binding]; other site
1097668016600	flexible hinge region; other site
1097668016601	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097668016602	putative switch regulator; other site
1097668016603	non-specific DNA interactions [nucleotide binding]; other site
1097668016604	DNA binding site [nucleotide binding]
1097668016605	sequence specific DNA binding site [nucleotide binding]; other site
1097668016606	putative cAMP binding site [chemical binding]; other site
1097668016607	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1097668016608	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
1097668016609	putative NAD(P) binding site [chemical binding]; other site
1097668016610	putative substrate binding site [chemical binding]; other site
1097668016611	catalytic Zn binding site [ion binding]; other site
1097668016612	structural Zn binding site [ion binding]; other site
1097668016613	Protein of unknown function (DUF3564); Region: DUF3564; pfam12087
1097668016614	Protein of unknown function (DUF2964); Region: DUF2964; pfam11177
1097668016615	Phasin protein; Region: Phasin_2; pfam09361
1097668016616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668016617	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1097668016618	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1097668016619	active site
1097668016620	ATP binding site [chemical binding]; other site
1097668016621	substrate binding site [chemical binding]; other site
1097668016622	activation loop (A-loop); other site
1097668016623	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
1097668016624	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
1097668016625	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668016626	ATP binding site [chemical binding]; other site
1097668016627	putative Mg++ binding site [ion binding]; other site
1097668016628	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668016629	nucleotide binding region [chemical binding]; other site
1097668016630	ATP-binding site [chemical binding]; other site
1097668016631	DEAD/H associated; Region: DEAD_assoc; pfam08494
1097668016632	galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288
1097668016633	putative phosphoketolase; Provisional; Region: PRK05261
1097668016634	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1097668016635	TPP-binding site; other site
1097668016636	XFP C-terminal domain; Region: XFP_C; pfam09363
1097668016637	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668016638	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016639	putative substrate translocation pore; other site
1097668016640	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016641	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1097668016642	active site
1097668016643	catalytic residues [active]
1097668016644	metal binding site [ion binding]; metal-binding site
1097668016645	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668016646	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668016647	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668016648	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016649	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668016650	putative dimerization interface [polypeptide binding]; other site
1097668016651	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097668016652	CoenzymeA binding site [chemical binding]; other site
1097668016653	subunit interaction site [polypeptide binding]; other site
1097668016654	PHB binding site; other site
1097668016655	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668016656	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1097668016657	aldehyde dehydrogenase family 7 member; Region: PLN02315
1097668016658	tetrameric interface [polypeptide binding]; other site
1097668016659	NAD binding site [chemical binding]; other site
1097668016660	catalytic residues [active]
1097668016661	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1097668016662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668016663	non-specific DNA binding site [nucleotide binding]; other site
1097668016664	salt bridge; other site
1097668016665	sequence-specific DNA binding site [nucleotide binding]; other site
1097668016666	Cupin domain; Region: Cupin_2; pfam07883
1097668016667	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097668016668	Cytochrome P450; Region: p450; cl12078
1097668016669	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1097668016670	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668016671	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668016672	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668016673	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097668016674	NIPSNAP; Region: NIPSNAP; pfam07978
1097668016675	NIPSNAP; Region: NIPSNAP; pfam07978
1097668016676	putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134
1097668016677	Predicted oxidoreductase [General function prediction only]; Region: COG3573
1097668016678	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843
1097668016679	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1097668016680	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1097668016681	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1097668016682	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1097668016683	shikimate 5-dehydrogenase; Region: aroE; TIGR00507
1097668016684	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668016685	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668016686	shikimate binding site; other site
1097668016687	NAD(P) binding site [chemical binding]; other site
1097668016688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668016689	binding surface
1097668016690	TPR motif; other site
1097668016691	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668016692	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668016693	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1097668016694	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668016695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016696	putative substrate translocation pore; other site
1097668016697	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668016698	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668016699	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668016700	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668016701	pyridoxamine kinase; Validated; Region: PRK05756
1097668016702	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1097668016703	dimer interface [polypeptide binding]; other site
1097668016704	pyridoxal binding site [chemical binding]; other site
1097668016705	ATP binding site [chemical binding]; other site
1097668016706	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1097668016707	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1097668016708	ligand binding site; other site
1097668016709	oligomer interface; other site
1097668016710	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1097668016711	dimer interface [polypeptide binding]; other site
1097668016712	N-terminal domain interface [polypeptide binding]; other site
1097668016713	sulfate 1 binding site; other site
1097668016714	glycogen synthase; Provisional; Region: glgA; PRK00654
1097668016715	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1097668016716	ADP-binding pocket [chemical binding]; other site
1097668016717	homodimer interface [polypeptide binding]; other site
1097668016718	glucose-1-dehydrogenase; Provisional; Region: PRK08936
1097668016719	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
1097668016720	NAD binding site [chemical binding]; other site
1097668016721	homodimer interface [polypeptide binding]; other site
1097668016722	active site
1097668016723	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
1097668016724	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668016725	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668016726	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668016727	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668016728	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1097668016729	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1097668016730	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1097668016731	tetrameric interface [polypeptide binding]; other site
1097668016732	NAD binding site [chemical binding]; other site
1097668016733	catalytic residues [active]
1097668016734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668016735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668016737	dimerization interface [polypeptide binding]; other site
1097668016738	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1097668016739	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097668016740	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1097668016741	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1097668016742	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1097668016743	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1097668016744	oligomer interface [polypeptide binding]; other site
1097668016745	metal binding site [ion binding]; metal-binding site
1097668016746	metal binding site [ion binding]; metal-binding site
1097668016747	putative Cl binding site [ion binding]; other site
1097668016748	basic sphincter; other site
1097668016749	hydrophobic gate; other site
1097668016750	periplasmic entrance; other site
1097668016751	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1097668016752	rRNA binding site [nucleotide binding]; other site
1097668016753	predicted 30S ribosome binding site; other site
1097668016754	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668016755	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1097668016756	active site
1097668016757	motif I; other site
1097668016758	motif II; other site
1097668016759	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1097668016760	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097668016761	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1097668016762	nucleotide binding site [chemical binding]; other site
1097668016763	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
1097668016764	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1097668016765	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1097668016766	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1097668016767	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1097668016768	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1097668016769	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1097668016770	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1097668016771	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
1097668016772	Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509
1097668016773	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1097668016774	putative di-iron ligands [ion binding]; other site
1097668016775	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1097668016776	hypothetical protein; Provisional; Region: PRK10508
1097668016777	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1097668016778	H-NS histone family; Region: Histone_HNS; pfam00816
1097668016779	Homeodomain-like domain; Region: HTH_23; pfam13384
1097668016780	Winged helix-turn helix; Region: HTH_29; pfam13551
1097668016781	Winged helix-turn helix; Region: HTH_33; pfam13592
1097668016782	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
1097668016783	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1097668016784	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
1097668016785	ligand binding site [chemical binding]; other site
1097668016786	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668016787	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668016788	TM-ABC transporter signature motif; other site
1097668016789	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668016790	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668016791	TM-ABC transporter signature motif; other site
1097668016792	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668016793	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668016794	Walker A/P-loop; other site
1097668016795	ATP binding site [chemical binding]; other site
1097668016796	Q-loop/lid; other site
1097668016797	ABC transporter signature motif; other site
1097668016798	Walker B; other site
1097668016799	D-loop; other site
1097668016800	H-loop/switch region; other site
1097668016801	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668016802	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668016803	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668016804	active site
1097668016805	Domain of unknown function (DUF718); Region: DUF718; pfam05336
1097668016806	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1097668016807	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668016808	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1097668016809	putative dimerization interface [polypeptide binding]; other site
1097668016810	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668016811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668016812	NAD(P) binding site [chemical binding]; other site
1097668016813	active site
1097668016814	L-rhamnonate dehydratase; Provisional; Region: PRK15440
1097668016815	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
1097668016816	putative active site pocket [active]
1097668016817	putative metal binding site [ion binding]; other site
1097668016818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016819	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668016820	putative substrate translocation pore; other site
1097668016821	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668016822	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668016823	NAD(P) binding site [chemical binding]; other site
1097668016824	active site
1097668016825	WHG domain; Region: WHG; pfam13305
1097668016826	BetR domain; Region: BetR; pfam08667
1097668016827	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668016828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016829	active site
1097668016830	phosphorylation site [posttranslational modification]
1097668016831	intermolecular recognition site; other site
1097668016832	dimerization interface [polypeptide binding]; other site
1097668016833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668016834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668016835	dimer interface [polypeptide binding]; other site
1097668016836	phosphorylation site [posttranslational modification]
1097668016837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668016838	ATP binding site [chemical binding]; other site
1097668016839	Mg2+ binding site [ion binding]; other site
1097668016840	G-X-G motif; other site
1097668016841	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668016842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016843	active site
1097668016844	phosphorylation site [posttranslational modification]
1097668016845	intermolecular recognition site; other site
1097668016846	dimerization interface [polypeptide binding]; other site
1097668016847	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
1097668016848	Part of AAA domain; Region: AAA_19; pfam13245
1097668016849	Family description; Region: UvrD_C_2; pfam13538
1097668016850	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668016851	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1097668016852	putative C-terminal domain interface [polypeptide binding]; other site
1097668016853	putative GSH binding site (G-site) [chemical binding]; other site
1097668016854	putative dimer interface [polypeptide binding]; other site
1097668016855	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
1097668016856	putative N-terminal domain interface [polypeptide binding]; other site
1097668016857	putative dimer interface [polypeptide binding]; other site
1097668016858	putative substrate binding pocket (H-site) [chemical binding]; other site
1097668016859	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668016860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016861	active site
1097668016862	phosphorylation site [posttranslational modification]
1097668016863	intermolecular recognition site; other site
1097668016864	dimerization interface [polypeptide binding]; other site
1097668016865	PAS fold; Region: PAS_4; pfam08448
1097668016866	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1097668016867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668016868	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1097668016869	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1097668016870	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1097668016871	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
1097668016872	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
1097668016873	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668016874	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668016875	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668016876	inhibitor site; inhibition site
1097668016877	active site
1097668016878	dimer interface [polypeptide binding]; other site
1097668016879	catalytic residue [active]
1097668016880	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668016881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016882	active site
1097668016883	phosphorylation site [posttranslational modification]
1097668016884	intermolecular recognition site; other site
1097668016885	dimerization interface [polypeptide binding]; other site
1097668016886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668016887	DNA binding site [nucleotide binding]
1097668016888	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668016889	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016891	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668016892	putative substrate translocation pore; other site
1097668016893	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668016894	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668016895	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668016896	non-specific DNA binding site [nucleotide binding]; other site
1097668016897	salt bridge; other site
1097668016898	sequence-specific DNA binding site [nucleotide binding]; other site
1097668016899	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1097668016900	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
1097668016901	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1097668016902	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1097668016903	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668016904	ligand binding site [chemical binding]; other site
1097668016905	manganese transport protein MntH; Reviewed; Region: PRK00701
1097668016906	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1097668016907	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668016908	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1097668016909	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668016910	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668016911	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668016912	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668016913	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1097668016914	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016915	active site
1097668016916	phosphorylation site [posttranslational modification]
1097668016917	intermolecular recognition site; other site
1097668016918	dimerization interface [polypeptide binding]; other site
1097668016919	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668016920	DNA binding site [nucleotide binding]
1097668016921	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1097668016922	HAMP domain; Region: HAMP; pfam00672
1097668016923	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668016924	dimer interface [polypeptide binding]; other site
1097668016925	phosphorylation site [posttranslational modification]
1097668016926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668016927	ATP binding site [chemical binding]; other site
1097668016928	Mg2+ binding site [ion binding]; other site
1097668016929	G-X-G motif; other site
1097668016930	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1097668016931	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1097668016932	[4Fe-4S] binding site [ion binding]; other site
1097668016933	molybdopterin cofactor binding site; other site
1097668016934	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1097668016935	molybdopterin cofactor binding site; other site
1097668016936	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1097668016937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1097668016938	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668016939	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668016940	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1097668016941	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1097668016942	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668016943	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1097668016944	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1097668016945	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1097668016946	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1097668016947	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1097668016948	active site
1097668016949	SAM binding site [chemical binding]; other site
1097668016950	homodimer interface [polypeptide binding]; other site
1097668016951	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1097668016952	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016953	active site
1097668016954	phosphorylation site [posttranslational modification]
1097668016955	intermolecular recognition site; other site
1097668016956	dimerization interface [polypeptide binding]; other site
1097668016957	ANTAR domain; Region: ANTAR; pfam03861
1097668016958	NMT1-like family; Region: NMT1_2; pfam13379
1097668016959	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668016960	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668016961	TPR motif; other site
1097668016962	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1097668016963	binding surface
1097668016964	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668016965	TPR motif; other site
1097668016966	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1097668016967	binding surface
1097668016968	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668016969	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
1097668016970	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
1097668016971	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1097668016972	nucleotide binding site [chemical binding]; other site
1097668016973	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1097668016974	SBD interface [polypeptide binding]; other site
1097668016975	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1097668016976	nucleotide binding site [chemical binding]; other site
1097668016977	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1097668016978	SBD interface [polypeptide binding]; other site
1097668016979	DNA-K related protein; Region: DUF3731; pfam12531
1097668016980	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1097668016981	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097668016982	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668016983	dimer interface [polypeptide binding]; other site
1097668016984	phosphorylation site [posttranslational modification]
1097668016985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668016986	ATP binding site [chemical binding]; other site
1097668016987	Mg2+ binding site [ion binding]; other site
1097668016988	G-X-G motif; other site
1097668016989	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668016990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668016991	active site
1097668016992	phosphorylation site [posttranslational modification]
1097668016993	dimerization interface [polypeptide binding]; other site
1097668016994	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1097668016995	active site
1097668016996	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1097668016997	MAPEG family; Region: MAPEG; cl09190
1097668016998	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
1097668016999	trimer interface [polypeptide binding]; other site
1097668017000	putative Zn binding site [ion binding]; other site
1097668017001	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668017002	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097668017003	active site
1097668017004	metal binding site [ion binding]; metal-binding site
1097668017005	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668017006	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1097668017007	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1097668017008	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1097668017009	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668017010	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1097668017011	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668017012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668017013	active site
1097668017014	phosphorylation site [posttranslational modification]
1097668017015	intermolecular recognition site; other site
1097668017016	dimerization interface [polypeptide binding]; other site
1097668017017	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668017018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668017019	active site
1097668017020	phosphorylation site [posttranslational modification]
1097668017021	intermolecular recognition site; other site
1097668017022	dimerization interface [polypeptide binding]; other site
1097668017023	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1097668017024	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
1097668017025	Cl binding site [ion binding]; other site
1097668017026	oligomer interface [polypeptide binding]; other site
1097668017027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1097668017028	SnoaL-like domain; Region: SnoaL_2; pfam12680
1097668017029	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668017030	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668017031	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1097668017032	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1097668017033	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1097668017034	putative active site [active]
1097668017035	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1097668017036	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1097668017037	Walker A/P-loop; other site
1097668017038	ATP binding site [chemical binding]; other site
1097668017039	Q-loop/lid; other site
1097668017040	ABC transporter signature motif; other site
1097668017041	Walker B; other site
1097668017042	D-loop; other site
1097668017043	H-loop/switch region; other site
1097668017044	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1097668017045	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668017046	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1097668017047	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1097668017048	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1097668017049	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1097668017050	PapC C-terminal domain; Region: PapC_C; pfam13953
1097668017051	putative chaperone protein EcpD; Provisional; Region: PRK09926
1097668017052	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1097668017053	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1097668017054	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668017055	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668017056	DNA-binding site [nucleotide binding]; DNA binding site
1097668017057	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668017058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668017059	homodimer interface [polypeptide binding]; other site
1097668017060	catalytic residue [active]
1097668017061	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668017062	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668017063	Walker A/P-loop; other site
1097668017064	ATP binding site [chemical binding]; other site
1097668017065	Q-loop/lid; other site
1097668017066	ABC transporter signature motif; other site
1097668017067	Walker B; other site
1097668017068	D-loop; other site
1097668017069	H-loop/switch region; other site
1097668017070	TOBE domain; Region: TOBE_2; pfam08402
1097668017071	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1097668017072	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1097668017073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668017074	dimer interface [polypeptide binding]; other site
1097668017075	conserved gate region; other site
1097668017076	putative PBP binding loops; other site
1097668017077	ABC-ATPase subunit interface; other site
1097668017078	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1097668017079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668017080	dimer interface [polypeptide binding]; other site
1097668017081	conserved gate region; other site
1097668017082	putative PBP binding loops; other site
1097668017083	ABC-ATPase subunit interface; other site
1097668017084	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1097668017085	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1097668017086	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1097668017087	NAD binding site [chemical binding]; other site
1097668017088	putative active site [active]
1097668017089	substrate binding site [chemical binding]; other site
1097668017090	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
1097668017091	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
1097668017092	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668017093	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
1097668017094	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1097668017095	DXD motif; other site
1097668017096	PilZ domain; Region: PilZ; pfam07238
1097668017097	cellulose synthase regulator protein; Provisional; Region: PRK11114
1097668017098	endo-1,4-D-glucanase; Provisional; Region: PRK11097
1097668017099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668017100	binding surface
1097668017101	TPR motif; other site
1097668017102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668017103	TPR motif; other site
1097668017104	binding surface
1097668017105	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1097668017106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668017107	TPR motif; other site
1097668017108	binding surface
1097668017109	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1097668017110	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668017111	TPR motif; other site
1097668017112	binding surface
1097668017113	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
1097668017114	transcriptional activator TtdR; Provisional; Region: PRK09801
1097668017115	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017116	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1097668017117	putative effector binding pocket; other site
1097668017118	putative dimerization interface [polypeptide binding]; other site
1097668017119	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
1097668017120	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668017121	N-terminal plug; other site
1097668017122	ligand-binding site [chemical binding]; other site
1097668017123	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
1097668017124	transcriptional regulator; Provisional; Region: PRK10632
1097668017125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017126	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668017127	putative effector binding pocket; other site
1097668017128	dimerization interface [polypeptide binding]; other site
1097668017129	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1097668017130	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668017131	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
1097668017132	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1097668017133	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1097668017134	Protein required for attachment to host cells; Region: Host_attach; pfam10116
1097668017135	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668017136	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668017137	Berberine and berberine like; Region: BBE; pfam08031
1097668017138	Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813
1097668017139	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259
1097668017140	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
1097668017141	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1097668017142	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
1097668017143	Cupin domain; Region: Cupin_2; cl17218
1097668017144	Water Stress and Hypersensitive response; Region: WHy; smart00769
1097668017145	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1097668017146	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1097668017147	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1097668017148	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1097668017149	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668017150	active site 1 [active]
1097668017151	dimer interface [polypeptide binding]; other site
1097668017152	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668017153	hexamer interface [polypeptide binding]; other site
1097668017154	active site 2 [active]
1097668017155	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
1097668017156	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
1097668017157	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
1097668017158	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
1097668017159	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
1097668017160	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
1097668017161	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
1097668017162	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097668017163	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668017164	Coenzyme A binding pocket [chemical binding]; other site
1097668017165	Cupin domain; Region: Cupin_2; cl17218
1097668017166	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668017167	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862
1097668017168	putative active site [active]
1097668017169	Zn binding site [ion binding]; other site
1097668017170	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668017171	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668017172	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668017173	active site
1097668017174	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1097668017175	metal binding site [ion binding]; metal-binding site
1097668017176	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1097668017177	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668017178	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1097668017179	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668017180	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668017181	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
1097668017182	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1097668017183	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1097668017184	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1097668017185	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
1097668017186	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1097668017187	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1097668017188	putative dimer interface [polypeptide binding]; other site
1097668017189	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1097668017190	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1097668017191	putative dimer interface [polypeptide binding]; other site
1097668017192	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1097668017193	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668017194	substrate binding pocket [chemical binding]; other site
1097668017195	membrane-bound complex binding site; other site
1097668017196	hinge residues; other site
1097668017197	H-NS histone family; Region: Histone_HNS; pfam00816
1097668017198	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1097668017199	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668017200	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668017201	DNA-binding site [nucleotide binding]; DNA binding site
1097668017202	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668017203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668017204	homodimer interface [polypeptide binding]; other site
1097668017205	catalytic residue [active]
1097668017206	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1097668017207	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668017208	inhibitor-cofactor binding pocket; inhibition site
1097668017209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668017210	catalytic residue [active]
1097668017211	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097668017212	CoenzymeA binding site [chemical binding]; other site
1097668017213	subunit interaction site [polypeptide binding]; other site
1097668017214	PHB binding site; other site
1097668017215	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668017216	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668017217	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017218	putative substrate translocation pore; other site
1097668017219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017220	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
1097668017221	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668017222	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668017223	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668017224	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017225	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668017226	putative effector binding pocket; other site
1097668017227	dimerization interface [polypeptide binding]; other site
1097668017228	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1097668017229	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1097668017230	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1097668017231	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1097668017232	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
1097668017233	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
1097668017234	active site residues [active]
1097668017235	dimer interface [polypeptide binding]; other site
1097668017236	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
1097668017237	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
1097668017238	aspartate carbamoyltransferase; Provisional; Region: PRK11891
1097668017239	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1097668017240	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1097668017241	Protein of unknown function (DUF497); Region: DUF497; pfam04365
1097668017242	CDP-diacylglycerol pyrophosphatase; Region: CDH; pfam02611
1097668017243	phenylhydantoinase; Validated; Region: PRK08323
1097668017244	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1097668017245	tetramer interface [polypeptide binding]; other site
1097668017246	active site
1097668017247	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485
1097668017248	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1097668017249	Na binding site [ion binding]; other site
1097668017250	putative substrate binding site [chemical binding]; other site
1097668017251	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1097668017252	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1097668017253	homodimer interface [polypeptide binding]; other site
1097668017254	active site
1097668017255	FMN binding site [chemical binding]; other site
1097668017256	substrate binding site [chemical binding]; other site
1097668017257	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1097668017258	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1097668017259	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668017260	allantoate amidohydrolase; Reviewed; Region: PRK12893
1097668017261	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668017262	active site
1097668017263	metal binding site [ion binding]; metal-binding site
1097668017264	dimer interface [polypeptide binding]; other site
1097668017265	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
1097668017266	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668017267	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1097668017268	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668017269	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1097668017270	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1097668017271	Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313
1097668017272	active site
1097668017273	HutD; Region: HutD; pfam05962
1097668017274	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1097668017275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668017276	DNA-binding site [nucleotide binding]; DNA binding site
1097668017277	UTRA domain; Region: UTRA; pfam07702
1097668017278	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1097668017279	active sites [active]
1097668017280	tetramer interface [polypeptide binding]; other site
1097668017281	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097668017282	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668017283	Coenzyme A binding pocket [chemical binding]; other site
1097668017284	chromosome condensation membrane protein; Provisional; Region: PRK14196
1097668017285	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
1097668017286	SxDxEG motif; other site
1097668017287	active site
1097668017288	metal binding site [ion binding]; metal-binding site
1097668017289	homopentamer interface [polypeptide binding]; other site
1097668017290	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
1097668017291	homodimer interface [polypeptide binding]; other site
1097668017292	homotetramer interface [polypeptide binding]; other site
1097668017293	active site pocket [active]
1097668017294	cleavage site
1097668017295	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1097668017296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668017297	dimer interface [polypeptide binding]; other site
1097668017298	conserved gate region; other site
1097668017299	putative PBP binding loops; other site
1097668017300	ABC-ATPase subunit interface; other site
1097668017301	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
1097668017302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668017303	dimer interface [polypeptide binding]; other site
1097668017304	conserved gate region; other site
1097668017305	putative PBP binding loops; other site
1097668017306	ABC-ATPase subunit interface; other site
1097668017307	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
1097668017308	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
1097668017309	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1097668017310	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668017311	Walker A/P-loop; other site
1097668017312	ATP binding site [chemical binding]; other site
1097668017313	Q-loop/lid; other site
1097668017314	ABC transporter signature motif; other site
1097668017315	Walker B; other site
1097668017316	D-loop; other site
1097668017317	H-loop/switch region; other site
1097668017318	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1097668017319	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668017320	Walker A/P-loop; other site
1097668017321	ATP binding site [chemical binding]; other site
1097668017322	Q-loop/lid; other site
1097668017323	ABC transporter signature motif; other site
1097668017324	Walker B; other site
1097668017325	D-loop; other site
1097668017326	H-loop/switch region; other site
1097668017327	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1097668017328	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
1097668017329	catalytic nucleophile [active]
1097668017330	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097668017331	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097668017332	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097668017333	putative active site [active]
1097668017334	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1097668017335	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1097668017336	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668017337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017338	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1097668017339	putative effector binding pocket; other site
1097668017340	putative dimerization interface [polypeptide binding]; other site
1097668017341	YciI-like protein; Reviewed; Region: PRK12866
1097668017342	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
1097668017343	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668017344	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668017345	ligand binding site [chemical binding]; other site
1097668017346	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
1097668017347	Predicted membrane protein [Function unknown]; Region: COG2261
1097668017348	imidazolonepropionase; Validated; Region: PRK09356
1097668017349	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1097668017350	active site
1097668017351	urocanate hydratase; Provisional; Region: PRK05414
1097668017352	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668017353	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668017354	putative DNA binding site [nucleotide binding]; other site
1097668017355	putative Zn2+ binding site [ion binding]; other site
1097668017356	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668017357	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668017358	MarR family; Region: MarR_2; pfam12802
1097668017359	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097668017360	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097668017361	PAS domain; Region: PAS; smart00091
1097668017362	PAS domain S-box; Region: sensory_box; TIGR00229
1097668017363	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668017364	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668017365	metal binding site [ion binding]; metal-binding site
1097668017366	active site
1097668017367	I-site; other site
1097668017368	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668017369	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668017370	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1097668017371	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1097668017372	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097668017373	putative acyl-acceptor binding pocket; other site
1097668017374	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668017375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668017376	active site
1097668017377	phosphorylation site [posttranslational modification]
1097668017378	intermolecular recognition site; other site
1097668017379	dimerization interface [polypeptide binding]; other site
1097668017380	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1097668017381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017382	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668017383	dimerization interface [polypeptide binding]; other site
1097668017384	Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464
1097668017385	heterodimer interface [polypeptide binding]; other site
1097668017386	multimer interface [polypeptide binding]; other site
1097668017387	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1097668017388	active site
1097668017389	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1097668017390	heterodimer interface [polypeptide binding]; other site
1097668017391	active site
1097668017392	Protein of unknown function (DUF2288); Region: DUF2288; pfam10052
1097668017393	Propionate catabolism activator; Region: PrpR_N; pfam06506
1097668017394	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1097668017395	PAS domain; Region: PAS; smart00091
1097668017396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668017397	Walker A motif; other site
1097668017398	ATP binding site [chemical binding]; other site
1097668017399	Walker B motif; other site
1097668017400	arginine finger; other site
1097668017401	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668017402	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668017403	tetramer interface [polypeptide binding]; other site
1097668017404	active site
1097668017405	Mg2+/Mn2+ binding site [ion binding]; other site
1097668017406	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1097668017407	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
1097668017408	dimer interface [polypeptide binding]; other site
1097668017409	active site
1097668017410	citrylCoA binding site [chemical binding]; other site
1097668017411	oxalacetate/citrate binding site [chemical binding]; other site
1097668017412	coenzyme A binding site [chemical binding]; other site
1097668017413	catalytic triad [active]
1097668017414	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1097668017415	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1097668017416	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097668017417	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1097668017418	putative outer membrane lipoprotein; Provisional; Region: PRK09967
1097668017419	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668017420	ligand binding site [chemical binding]; other site
1097668017421	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1097668017422	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1097668017423	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668017424	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1097668017425	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1097668017426	carboxyltransferase (CT) interaction site; other site
1097668017427	biotinylation site [posttranslational modification]; other site
1097668017428	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1097668017429	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1097668017430	isovaleryl-CoA dehydrogenase; Region: PLN02519
1097668017431	substrate binding site [chemical binding]; other site
1097668017432	FAD binding site [chemical binding]; other site
1097668017433	catalytic base [active]
1097668017434	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668017435	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668017436	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1097668017437	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668017438	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668017439	tetramerization interface [polypeptide binding]; other site
1097668017440	NAD(P) binding site [chemical binding]; other site
1097668017441	catalytic residues [active]
1097668017442	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668017443	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668017444	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1097668017445	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017446	putative substrate translocation pore; other site
1097668017447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017448	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668017449	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668017450	substrate binding pocket [chemical binding]; other site
1097668017451	membrane-bound complex binding site; other site
1097668017452	hinge residues; other site
1097668017453	Predicted deacylase [General function prediction only]; Region: COG3608
1097668017454	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
1097668017455	active site
1097668017456	Zn binding site [ion binding]; other site
1097668017457	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668017458	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668017459	trimer interface [polypeptide binding]; other site
1097668017460	eyelet of channel; other site
1097668017461	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
1097668017462	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668017463	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668017464	homodimer interface [polypeptide binding]; other site
1097668017465	catalytic residue [active]
1097668017466	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
1097668017467	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668017468	TrkA-C domain; Region: TrkA_C; pfam02080
1097668017469	TrkA-C domain; Region: TrkA_C; pfam02080
1097668017470	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668017471	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097668017472	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1097668017473	FMN binding site [chemical binding]; other site
1097668017474	active site
1097668017475	substrate binding site [chemical binding]; other site
1097668017476	catalytic residue [active]
1097668017477	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668017478	putative DNA binding site [nucleotide binding]; other site
1097668017479	dimerization interface [polypeptide binding]; other site
1097668017480	putative Zn2+ binding site [ion binding]; other site
1097668017481	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1097668017482	homodimer interface [polypeptide binding]; other site
1097668017483	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1097668017484	active site pocket [active]
1097668017485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097668017486	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1097668017487	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668017488	dimer interface [polypeptide binding]; other site
1097668017489	conserved gate region; other site
1097668017490	putative PBP binding loops; other site
1097668017491	ABC-ATPase subunit interface; other site
1097668017492	2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258
1097668017493	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668017494	Walker A/P-loop; other site
1097668017495	ATP binding site [chemical binding]; other site
1097668017496	Q-loop/lid; other site
1097668017497	ABC transporter signature motif; other site
1097668017498	Walker B; other site
1097668017499	D-loop; other site
1097668017500	H-loop/switch region; other site
1097668017501	TOBE domain; Region: TOBE_2; pfam08402
1097668017502	2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046
1097668017503	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1097668017504	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1097668017505	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668017506	substrate binding pocket [chemical binding]; other site
1097668017507	membrane-bound complex binding site; other site
1097668017508	hinge residues; other site
1097668017509	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668017510	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668017511	substrate binding pocket [chemical binding]; other site
1097668017512	membrane-bound complex binding site; other site
1097668017513	hinge residues; other site
1097668017514	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668017515	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668017516	dimer interface [polypeptide binding]; other site
1097668017517	phosphorylation site [posttranslational modification]
1097668017518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668017519	ATP binding site [chemical binding]; other site
1097668017520	Mg2+ binding site [ion binding]; other site
1097668017521	G-X-G motif; other site
1097668017522	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668017523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668017524	active site
1097668017525	phosphorylation site [posttranslational modification]
1097668017526	intermolecular recognition site; other site
1097668017527	dimerization interface [polypeptide binding]; other site
1097668017528	hydroperoxidase II; Provisional; Region: katE; PRK11249
1097668017529	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
1097668017530	tetramer interface [polypeptide binding]; other site
1097668017531	heme binding pocket [chemical binding]; other site
1097668017532	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1097668017533	domain interactions; other site
1097668017534	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
1097668017535	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
1097668017536	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
1097668017537	peptidase domain interface [polypeptide binding]; other site
1097668017538	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
1097668017539	active site
1097668017540	catalytic triad [active]
1097668017541	calcium binding site [ion binding]; other site
1097668017542	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1097668017543	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1097668017544	catalytic triad [active]
1097668017545	conserved cis-peptide bond; other site
1097668017546	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668017547	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668017548	catalytic loop [active]
1097668017549	iron binding site [ion binding]; other site
1097668017550	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668017551	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
1097668017552	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1097668017553	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668017554	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668017555	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668017556	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1097668017557	Ligand binding site; other site
1097668017558	metal-binding site
1097668017559	Predicted membrane protein (DUF2335); Region: DUF2335; cl02210
1097668017560	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668017561	active site
1097668017562	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
1097668017563	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1097668017564	Fe-S cluster binding site [ion binding]; other site
1097668017565	active site
1097668017566	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668017567	adhesin; Provisional; Region: PRK09752
1097668017568	Cache domain; Region: Cache_2; pfam08269
1097668017569	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1097668017570	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668017571	dimer interface [polypeptide binding]; other site
1097668017572	putative CheW interface [polypeptide binding]; other site
1097668017573	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1097668017574	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1097668017575	metal binding site [ion binding]; metal-binding site
1097668017576	putative dimer interface [polypeptide binding]; other site
1097668017577	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668017578	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668017579	DNA-binding site [nucleotide binding]; DNA binding site
1097668017580	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668017581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668017582	homodimer interface [polypeptide binding]; other site
1097668017583	catalytic residue [active]
1097668017584	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
1097668017585	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1097668017586	inhibitor-cofactor binding pocket; inhibition site
1097668017587	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668017588	catalytic residue [active]
1097668017589	succinic semialdehyde dehydrogenase; Region: PLN02278
1097668017590	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668017591	tetramerization interface [polypeptide binding]; other site
1097668017592	NAD(P) binding site [chemical binding]; other site
1097668017593	catalytic residues [active]
1097668017594	Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363
1097668017595	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1097668017596	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1097668017597	putative active site [active]
1097668017598	putative metal binding site [ion binding]; other site
1097668017599	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1097668017600	active site
1097668017601	nucleophile elbow; other site
1097668017602	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668017603	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1097668017604	catalytic triad [active]
1097668017605	conserved cis-peptide bond; other site
1097668017606	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
1097668017607	SelR domain; Region: SelR; pfam01641
1097668017608	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1097668017609	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1097668017610	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1097668017611	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1097668017612	Walker A/P-loop; other site
1097668017613	ATP binding site [chemical binding]; other site
1097668017614	Q-loop/lid; other site
1097668017615	ABC transporter signature motif; other site
1097668017616	Walker B; other site
1097668017617	D-loop; other site
1097668017618	H-loop/switch region; other site
1097668017619	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1097668017620	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1097668017621	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668017622	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668017623	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1097668017624	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1097668017625	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1097668017626	putative dimer interface [polypeptide binding]; other site
1097668017627	N-terminal domain interface [polypeptide binding]; other site
1097668017628	putative substrate binding pocket (H-site) [chemical binding]; other site
1097668017629	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1097668017630	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017631	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668017632	dimerization interface [polypeptide binding]; other site
1097668017633	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1097668017634	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1097668017635	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1097668017636	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668017637	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1097668017638	Cytochrome c; Region: Cytochrom_C; cl11414
1097668017639	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1097668017640	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1097668017641	Trp docking motif [polypeptide binding]; other site
1097668017642	active site
1097668017643	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1097668017644	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1097668017645	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1097668017646	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668017647	substrate binding site [chemical binding]; other site
1097668017648	oxyanion hole (OAH) forming residues; other site
1097668017649	trimer interface [polypeptide binding]; other site
1097668017650	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1097668017651	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1097668017652	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974
1097668017653	active site
1097668017654	acyl-activating enzyme (AAE) consensus motif; other site
1097668017655	putative CoA binding site [chemical binding]; other site
1097668017656	AMP binding site [chemical binding]; other site
1097668017657	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668017658	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668017659	active site
1097668017660	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1097668017661	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668017662	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668017663	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1097668017664	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017665	putative substrate translocation pore; other site
1097668017666	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
1097668017667	hypothetical protein; Provisional; Region: PRK02237
1097668017668	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1097668017669	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1097668017670	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668017671	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668017672	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1097668017673	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1097668017674	active site
1097668017675	substrate binding site [chemical binding]; other site
1097668017676	Mg2+ binding site [ion binding]; other site
1097668017677	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1097668017678	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1097668017679	DNA binding site [nucleotide binding]
1097668017680	active site
1097668017681	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1097668017682	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668017683	ligand binding site [chemical binding]; other site
1097668017684	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1097668017685	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668017686	circadian clock protein KaiC; Reviewed; Region: PRK09302
1097668017687	ATP binding site [chemical binding]; other site
1097668017688	Walker A motif; other site
1097668017689	Walker B motif; other site
1097668017690	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668017691	Walker A motif; other site
1097668017692	ATP binding site [chemical binding]; other site
1097668017693	Walker B motif; other site
1097668017694	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668017695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668017696	active site
1097668017697	phosphorylation site [posttranslational modification]
1097668017698	intermolecular recognition site; other site
1097668017699	dimerization interface [polypeptide binding]; other site
1097668017700	CsbD-like; Region: CsbD; pfam05532
1097668017701	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1097668017702	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
1097668017703	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668017704	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1097668017705	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1097668017706	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
1097668017707	CoA binding domain; Region: CoA_binding_2; pfam13380
1097668017708	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1097668017709	formyl-coenzyme A transferase; Provisional; Region: PRK05398
1097668017710	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668017711	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668017712	dimer interface [polypeptide binding]; other site
1097668017713	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1097668017714	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1097668017715	CoA-ligase; Region: Ligase_CoA; pfam00549
1097668017716	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1097668017717	CoA binding domain; Region: CoA_binding; smart00881
1097668017718	CoA-ligase; Region: Ligase_CoA; pfam00549
1097668017719	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668017720	DNA-binding site [nucleotide binding]; DNA binding site
1097668017721	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1097668017722	FCD domain; Region: FCD; pfam07729
1097668017723	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1097668017724	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668017725	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668017726	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668017727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017728	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1097668017729	putative dimerization interface [polypeptide binding]; other site
1097668017730	oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259
1097668017731	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017732	putative substrate translocation pore; other site
1097668017733	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668017734	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017735	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1097668017736	putative dimerization interface [polypeptide binding]; other site
1097668017737	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668017738	Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115
1097668017739	NAD(P) binding site [chemical binding]; other site
1097668017740	catalytic residues [active]
1097668017741	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1097668017742	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1097668017743	PhnA protein; Region: PhnA; pfam03831
1097668017744	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1097668017745	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097668017746	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1097668017747	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1097668017748	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
1097668017749	active site
1097668017750	Zn binding site [ion binding]; other site
1097668017751	allantoate amidohydrolase; Reviewed; Region: PRK12893
1097668017752	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668017753	active site
1097668017754	metal binding site [ion binding]; metal-binding site
1097668017755	dimer interface [polypeptide binding]; other site
1097668017756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017757	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668017758	putative substrate translocation pore; other site
1097668017759	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668017760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017761	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668017762	dimerization interface [polypeptide binding]; other site
1097668017763	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1097668017764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017765	putative substrate translocation pore; other site
1097668017766	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1097668017767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668017768	active site
1097668017769	phosphorylation site [posttranslational modification]
1097668017770	intermolecular recognition site; other site
1097668017771	dimerization interface [polypeptide binding]; other site
1097668017772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668017773	Walker A motif; other site
1097668017774	ATP binding site [chemical binding]; other site
1097668017775	Walker B motif; other site
1097668017776	arginine finger; other site
1097668017777	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668017778	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1097668017779	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1097668017780	dimer interface [polypeptide binding]; other site
1097668017781	phosphorylation site [posttranslational modification]
1097668017782	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668017783	ATP binding site [chemical binding]; other site
1097668017784	Mg2+ binding site [ion binding]; other site
1097668017785	G-X-G motif; other site
1097668017786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1097668017787	active site
1097668017788	dimerization interface [polypeptide binding]; other site
1097668017789	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
1097668017790	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
1097668017791	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1097668017792	Restriction endonuclease; Region: Mrr_cat; pfam04471
1097668017793	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
1097668017794	Domain of unknown function (DUF1996); Region: DUF1996; pfam09362
1097668017795	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
1097668017796	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
1097668017797	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
1097668017798	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
1097668017799	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668017800	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
1097668017801	Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006
1097668017802	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668017803	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1097668017804	haemagglutination activity domain; Region: Haemagg_act; cl05436
1097668017805	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1097668017806	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1097668017807	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1097668017808	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
1097668017809	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1097668017810	Protein of unknown function (DUF3489); Region: DUF3489; pfam11994
1097668017811	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1097668017812	ParB-like nuclease domain; Region: ParBc; pfam02195
1097668017813	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1097668017814	DNA methylase; Region: N6_N4_Mtase; pfam01555
1097668017815	hypothetical protein; Validated; Region: PRK07078
1097668017816	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
1097668017817	Part of AAA domain; Region: AAA_19; pfam13245
1097668017818	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1097668017819	AAA domain; Region: AAA_12; pfam13087
1097668017820	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1097668017821	putative active site [active]
1097668017822	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
1097668017823	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1097668017824	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
1097668017825	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
1097668017826	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668017827	active site
1097668017828	DNA binding site [nucleotide binding]
1097668017829	Int/Topo IB signature motif; other site
1097668017830	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1097668017831	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1097668017832	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1097668017833	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1097668017834	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668017835	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097668017836	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668017837	DNA binding residues [nucleotide binding]
1097668017838	DNA primase; Validated; Region: dnaG; PRK05667
1097668017839	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1097668017840	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1097668017841	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1097668017842	active site
1097668017843	metal binding site [ion binding]; metal-binding site
1097668017844	interdomain interaction site; other site
1097668017845	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1097668017846	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879
1097668017847	Yqey-like protein; Region: YqeY; pfam09424
1097668017848	Predicted flavoproteins [General function prediction only]; Region: COG2081
1097668017849	UGMP family protein; Validated; Region: PRK09604
1097668017850	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1097668017851	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668017852	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
1097668017853	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1097668017854	dimer interface [polypeptide binding]; other site
1097668017855	N-terminal domain interface [polypeptide binding]; other site
1097668017856	putative substrate binding pocket (H-site) [chemical binding]; other site
1097668017857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668017858	putative substrate translocation pore; other site
1097668017859	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668017860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668017861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668017862	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668017863	dimerization interface [polypeptide binding]; other site
1097668017864	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1097668017865	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1097668017866	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1097668017867	TPP-binding site; other site
1097668017868	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097668017869	PYR/PP interface [polypeptide binding]; other site
1097668017870	dimer interface [polypeptide binding]; other site
1097668017871	TPP binding site [chemical binding]; other site
1097668017872	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668017873	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1097668017874	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1097668017875	substrate binding pocket [chemical binding]; other site
1097668017876	chain length determination region; other site
1097668017877	substrate-Mg2+ binding site; other site
1097668017878	catalytic residues [active]
1097668017879	aspartate-rich region 1; other site
1097668017880	active site lid residues [active]
1097668017881	aspartate-rich region 2; other site
1097668017882	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1097668017883	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668017884	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668017885	[2Fe-2S] cluster binding site [ion binding]; other site
1097668017886	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
1097668017887	alpha subunit interface [polypeptide binding]; other site
1097668017888	active site
1097668017889	substrate binding site [chemical binding]; other site
1097668017890	Fe binding site [ion binding]; other site
1097668017891	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1097668017892	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1097668017893	active site residue [active]
1097668017894	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1097668017895	active site residue [active]
1097668017896	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1097668017897	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1097668017898	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668017899	DNA polymerase I; Provisional; Region: PRK05755
1097668017900	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1097668017901	active site
1097668017902	metal binding site 1 [ion binding]; metal-binding site
1097668017903	putative 5' ssDNA interaction site; other site
1097668017904	metal binding site 3; metal-binding site
1097668017905	metal binding site 2 [ion binding]; metal-binding site
1097668017906	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1097668017907	putative DNA binding site [nucleotide binding]; other site
1097668017908	putative metal binding site [ion binding]; other site
1097668017909	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1097668017910	active site
1097668017911	catalytic site [active]
1097668017912	substrate binding site [chemical binding]; other site
1097668017913	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1097668017914	active site
1097668017915	DNA binding site [nucleotide binding]
1097668017916	catalytic site [active]
1097668017917	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1097668017918	AMP nucleosidase; Provisional; Region: PRK08292
1097668017919	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1097668017920	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1097668017921	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1097668017922	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
1097668017923	putative active site [active]
1097668017924	putative substrate binding site [chemical binding]; other site
1097668017925	ATP binding site [chemical binding]; other site
1097668017926	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668017927	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668017928	putative Zn2+ binding site [ion binding]; other site
1097668017929	putative DNA binding site [nucleotide binding]; other site
1097668017930	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1097668017931	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
1097668017932	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
1097668017933	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
1097668017934	molybdenum-pterin binding domain; Region: Mop; TIGR00638
1097668017935	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1097668017936	CHAD domain; Region: CHAD; pfam05235
1097668017937	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1097668017938	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1097668017939	Protein of unknown function (DUF2866); Region: DUF2866; pfam11065
1097668017940	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
1097668017941	RES domain; Region: RES; smart00953
1097668017942	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1097668017943	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
1097668017944	active site
1097668017945	DNA binding site [nucleotide binding]
1097668017946	Int/Topo IB signature motif; other site
1097668017947	catalytic residues [active]
1097668017948	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668017949	active site
1097668017950	metal binding site [ion binding]; metal-binding site
1097668017951	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
1097668017952	glycogen synthase; Provisional; Region: glgA; PRK00654
1097668017953	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1097668017954	ADP-binding pocket [chemical binding]; other site
1097668017955	homodimer interface [polypeptide binding]; other site
1097668017956	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1097668017957	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1097668017958	active site
1097668017959	catalytic site [active]
1097668017960	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1097668017961	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
1097668017962	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1097668017963	active site
1097668017964	homodimer interface [polypeptide binding]; other site
1097668017965	catalytic site [active]
1097668017966	acceptor binding site [chemical binding]; other site
1097668017967	trehalose synthase; Region: treS_nterm; TIGR02456
1097668017968	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
1097668017969	active site
1097668017970	catalytic site [active]
1097668017971	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
1097668017972	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
1097668017973	glycogen branching enzyme; Provisional; Region: PRK05402
1097668017974	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1097668017975	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1097668017976	active site
1097668017977	catalytic site [active]
1097668017978	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1097668017979	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1097668017980	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1097668017981	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1097668017982	active site
1097668017983	catalytic site [active]
1097668017984	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1097668017985	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1097668017986	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1097668017987	catalytic site [active]
1097668017988	active site
1097668017989	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1097668017990	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1097668017991	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1097668017992	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
1097668017993	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1097668017994	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1097668017995	active site
1097668017996	catalytic site [active]
1097668017997	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1097668017998	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1097668017999	Domain of unknown function DUF21; Region: DUF21; pfam01595
1097668018000	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1097668018001	Transporter associated domain; Region: CorC_HlyC; smart01091
1097668018002	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668018003	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668018004	dimer interface [polypeptide binding]; other site
1097668018005	phosphorylation site [posttranslational modification]
1097668018006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1097668018007	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097668018008	active site
1097668018009	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1097668018010	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1097668018011	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668018012	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668018013	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1097668018014	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668018015	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1097668018016	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668018017	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
1097668018018	tyrosine kinase; Provisional; Region: PRK11519
1097668018019	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1097668018020	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668018021	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668018022	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1097668018023	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1097668018024	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668018025	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668018026	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668018027	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
1097668018028	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1097668018029	homodimer interface [polypeptide binding]; other site
1097668018030	substrate-cofactor binding pocket; other site
1097668018031	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668018032	catalytic residue [active]
1097668018033	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1097668018034	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1097668018035	active site
1097668018036	tetramer interface [polypeptide binding]; other site
1097668018037	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1097668018038	active site
1097668018039	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1097668018040	Colicin V production protein; Region: Colicin_V; pfam02674
1097668018041	Sporulation related domain; Region: SPOR; pfam05036
1097668018042	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1097668018043	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1097668018044	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1097668018045	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1097668018046	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1097668018047	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1097668018048	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1097668018049	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1097668018050	substrate binding site [chemical binding]; other site
1097668018051	active site
1097668018052	catalytic residues [active]
1097668018053	heterodimer interface [polypeptide binding]; other site
1097668018054	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1097668018055	DNA methylase; Region: N6_N4_Mtase; pfam01555
1097668018056	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1097668018057	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1097668018058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668018059	catalytic residue [active]
1097668018060	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1097668018061	active site
1097668018062	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1097668018063	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1097668018064	dimerization interface 3.5A [polypeptide binding]; other site
1097668018065	active site
1097668018066	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
1097668018067	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1097668018068	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1097668018069	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1097668018070	tartrate dehydrogenase; Region: TTC; TIGR02089
1097668018071	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1097668018072	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1097668018073	substrate binding site [chemical binding]; other site
1097668018074	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1097668018075	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1097668018076	substrate binding site [chemical binding]; other site
1097668018077	ligand binding site [chemical binding]; other site
1097668018078	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1097668018079	PemK-like protein; Region: PemK; pfam02452
1097668018080	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1097668018081	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1097668018082	dimer interface [polypeptide binding]; other site
1097668018083	active site
1097668018084	citrylCoA binding site [chemical binding]; other site
1097668018085	NADH binding [chemical binding]; other site
1097668018086	cationic pore residues; other site
1097668018087	oxalacetate/citrate binding site [chemical binding]; other site
1097668018088	coenzyme A binding site [chemical binding]; other site
1097668018089	catalytic triad [active]
1097668018090	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
1097668018091	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1097668018092	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1097668018093	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
1097668018094	L-aspartate oxidase; Provisional; Region: PRK06175
1097668018095	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1097668018096	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1097668018097	SdhC subunit interface [polypeptide binding]; other site
1097668018098	proximal heme binding site [chemical binding]; other site
1097668018099	cardiolipin binding site; other site
1097668018100	Iron-sulfur protein interface; other site
1097668018101	proximal quinone binding site [chemical binding]; other site
1097668018102	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1097668018103	Iron-sulfur protein interface; other site
1097668018104	proximal quinone binding site [chemical binding]; other site
1097668018105	SdhD (CybS) interface [polypeptide binding]; other site
1097668018106	proximal heme binding site [chemical binding]; other site
1097668018107	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097668018108	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668018109	DNA-binding site [nucleotide binding]; DNA binding site
1097668018110	UTRA domain; Region: UTRA; pfam07702
1097668018111	malate dehydrogenase; Provisional; Region: PRK05442
1097668018112	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1097668018113	NAD(P) binding site [chemical binding]; other site
1097668018114	dimer interface [polypeptide binding]; other site
1097668018115	malate binding site [chemical binding]; other site
1097668018116	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1097668018117	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1097668018118	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
1097668018119	dimer interface [polypeptide binding]; other site
1097668018120	active site
1097668018121	citrylCoA binding site [chemical binding]; other site
1097668018122	oxalacetate/citrate binding site [chemical binding]; other site
1097668018123	coenzyme A binding site [chemical binding]; other site
1097668018124	catalytic triad [active]
1097668018125	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1097668018126	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1097668018127	aconitate hydratase; Provisional; Region: acnA; PRK12881
1097668018128	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1097668018129	substrate binding site [chemical binding]; other site
1097668018130	ligand binding site [chemical binding]; other site
1097668018131	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1097668018132	substrate binding site [chemical binding]; other site
1097668018133	Protein of unknown function (DUF2917); Region: DUF2917; pfam11142
1097668018134	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668018135	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668018136	DNA-binding site [nucleotide binding]; DNA binding site
1097668018137	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668018138	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668018139	homodimer interface [polypeptide binding]; other site
1097668018140	catalytic residue [active]
1097668018141	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1097668018142	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1097668018143	Moco binding site; other site
1097668018144	metal coordination site [ion binding]; other site
1097668018145	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1097668018146	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1097668018147	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1097668018148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018149	active site
1097668018150	phosphorylation site [posttranslational modification]
1097668018151	intermolecular recognition site; other site
1097668018152	dimerization interface [polypeptide binding]; other site
1097668018153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668018154	DNA binding site [nucleotide binding]
1097668018155	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1097668018156	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668018157	dimerization interface [polypeptide binding]; other site
1097668018158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668018159	dimer interface [polypeptide binding]; other site
1097668018160	phosphorylation site [posttranslational modification]
1097668018161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018162	ATP binding site [chemical binding]; other site
1097668018163	G-X-G motif; other site
1097668018164	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668018165	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668018166	ligand binding site [chemical binding]; other site
1097668018167	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1097668018168	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668018169	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668018170	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1097668018171	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1097668018172	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1097668018173	active site residue [active]
1097668018174	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668018175	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
1097668018176	putative NAD(P) binding site [chemical binding]; other site
1097668018177	active site
1097668018178	putative substrate binding site [chemical binding]; other site
1097668018179	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1097668018180	putative aldolase; Validated; Region: PRK08130
1097668018181	intersubunit interface [polypeptide binding]; other site
1097668018182	active site
1097668018183	Zn2+ binding site [ion binding]; other site
1097668018184	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1097668018185	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1097668018186	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668018187	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668018188	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668018189	DNA-binding site [nucleotide binding]; DNA binding site
1097668018190	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668018191	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1097668018192	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668018193	catalytic residues [active]
1097668018194	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
1097668018195	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668018196	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668018197	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668018198	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1097668018199	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1097668018200	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668018201	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668018202	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668018203	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1097668018204	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1097668018205	Metal-binding active site; metal-binding site
1097668018206	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1097668018207	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1097668018208	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
1097668018209	putative ligand binding site [chemical binding]; other site
1097668018210	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668018211	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668018212	TM-ABC transporter signature motif; other site
1097668018213	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668018214	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668018215	Walker A/P-loop; other site
1097668018216	ATP binding site [chemical binding]; other site
1097668018217	Q-loop/lid; other site
1097668018218	ABC transporter signature motif; other site
1097668018219	Walker B; other site
1097668018220	D-loop; other site
1097668018221	H-loop/switch region; other site
1097668018222	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668018223	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668018224	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668018225	DNA binding site [nucleotide binding]
1097668018226	domain linker motif; other site
1097668018227	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
1097668018228	dimerization interface [polypeptide binding]; other site
1097668018229	ligand binding site [chemical binding]; other site
1097668018230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
1097668018231	short chain dehydrogenase; Validated; Region: PRK08264
1097668018232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668018233	NAD(P) binding site [chemical binding]; other site
1097668018234	active site
1097668018235	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668018236	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1097668018237	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668018238	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668018239	dimerization interface [polypeptide binding]; other site
1097668018240	ligand binding site [chemical binding]; other site
1097668018241	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
1097668018242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018243	active site
1097668018244	phosphorylation site [posttranslational modification]
1097668018245	intermolecular recognition site; other site
1097668018246	dimerization interface [polypeptide binding]; other site
1097668018247	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668018248	DNA binding site [nucleotide binding]
1097668018249	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1097668018250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668018251	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668018252	dimer interface [polypeptide binding]; other site
1097668018253	phosphorylation site [posttranslational modification]
1097668018254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018255	ATP binding site [chemical binding]; other site
1097668018256	Mg2+ binding site [ion binding]; other site
1097668018257	G-X-G motif; other site
1097668018258	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668018259	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668018260	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668018261	dimerization interface [polypeptide binding]; other site
1097668018262	substrate binding pocket [chemical binding]; other site
1097668018263	putative aminotransferase; Provisional; Region: PRK12414
1097668018264	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668018265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668018266	homodimer interface [polypeptide binding]; other site
1097668018267	catalytic residue [active]
1097668018268	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1097668018269	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668018270	substrate binding pocket [chemical binding]; other site
1097668018271	membrane-bound complex binding site; other site
1097668018272	hinge residues; other site
1097668018273	PemK-like protein; Region: PemK; cl00995
1097668018274	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1097668018275	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668018276	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018277	putative substrate translocation pore; other site
1097668018278	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018279	Domain of unknown function DUF29; Region: DUF29; pfam01724
1097668018280	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1097668018281	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1097668018282	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1097668018283	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1097668018284	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
1097668018285	Uncharacterized conserved protein [Function unknown]; Region: COG5361
1097668018286	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
1097668018287	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
1097668018288	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
1097668018289	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1097668018290	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1097668018291	metal-binding site [ion binding]
1097668018292	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097668018293	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
1097668018294	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668018295	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668018296	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1097668018297	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1097668018298	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1097668018299	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668018300	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668018301	conserved cys residue [active]
1097668018302	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668018303	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668018304	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668018305	trimer interface [polypeptide binding]; other site
1097668018306	eyelet of channel; other site
1097668018307	galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288
1097668018308	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1097668018309	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1097668018310	Sulfatase; Region: Sulfatase; cl17466
1097668018311	choline-sulfatase; Region: chol_sulfatase; TIGR03417
1097668018312	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
1097668018313	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668018314	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668018315	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668018316	dimerization interface [polypeptide binding]; other site
1097668018317	substrate binding pocket [chemical binding]; other site
1097668018318	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
1097668018319	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1097668018320	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1097668018321	putative active site [active]
1097668018322	putative substrate binding site [chemical binding]; other site
1097668018323	putative cosubstrate binding site; other site
1097668018324	catalytic site [active]
1097668018325	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1097668018326	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1097668018327	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668018328	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1097668018329	FAD binding pocket [chemical binding]; other site
1097668018330	FAD binding motif [chemical binding]; other site
1097668018331	phosphate binding motif [ion binding]; other site
1097668018332	beta-alpha-beta structure motif; other site
1097668018333	NAD binding pocket [chemical binding]; other site
1097668018334	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668018335	catalytic loop [active]
1097668018336	iron binding site [ion binding]; other site
1097668018337	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668018338	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668018339	[2Fe-2S] cluster binding site [ion binding]; other site
1097668018340	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1097668018341	putative alpha subunit interface [polypeptide binding]; other site
1097668018342	putative active site [active]
1097668018343	putative substrate binding site [chemical binding]; other site
1097668018344	Fe binding site [ion binding]; other site
1097668018345	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668018346	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668018347	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668018348	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668018349	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668018350	Domain of unknown function (DUF3483); Region: DUF3483; pfam11982
1097668018351	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1097668018352	Cysteine-rich domain; Region: CCG; pfam02754
1097668018353	Cysteine-rich domain; Region: CCG; pfam02754
1097668018354	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1097668018355	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1097668018356	putative active site [active]
1097668018357	putative FMN binding site [chemical binding]; other site
1097668018358	putative substrate binding site [chemical binding]; other site
1097668018359	putative catalytic residue [active]
1097668018360	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668018361	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
1097668018362	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1097668018363	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1097668018364	active site
1097668018365	dimer interface [polypeptide binding]; other site
1097668018366	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668018367	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668018368	conserved cys residue [active]
1097668018369	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668018370	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097668018371	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668018372	Coenzyme A binding pocket [chemical binding]; other site
1097668018373	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1097668018374	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1097668018375	NAD binding site [chemical binding]; other site
1097668018376	catalytic Zn binding site [ion binding]; other site
1097668018377	structural Zn binding site [ion binding]; other site
1097668018378	transcriptional regulator BetI; Validated; Region: PRK00767
1097668018379	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668018380	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1097668018381	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1097668018382	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
1097668018383	tetrameric interface [polypeptide binding]; other site
1097668018384	NAD binding site [chemical binding]; other site
1097668018385	catalytic residues [active]
1097668018386	choline dehydrogenase; Validated; Region: PRK02106
1097668018387	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668018388	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187
1097668018389	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
1097668018390	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497
1097668018391	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1097668018392	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645
1097668018393	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
1097668018394	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719
1097668018395	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
1097668018396	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
1097668018397	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1097668018398	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
1097668018399	benzoate transport; Region: 2A0115; TIGR00895
1097668018400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018401	putative substrate translocation pore; other site
1097668018402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018403	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
1097668018404	active site
1097668018405	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
1097668018406	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1097668018407	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1097668018408	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668018409	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
1097668018410	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1097668018411	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
1097668018412	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1097668018413	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668018414	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1097668018415	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1097668018416	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1097668018417	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668018418	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668018419	conserved cys residue [active]
1097668018420	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097668018421	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668018422	aldolase II superfamily protein; Provisional; Region: PRK07044
1097668018423	intersubunit interface [polypeptide binding]; other site
1097668018424	active site
1097668018425	Zn2+ binding site [ion binding]; other site
1097668018426	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1097668018427	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
1097668018428	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668018429	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668018430	conserved cys residue [active]
1097668018431	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668018432	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1097668018433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668018434	dimer interface [polypeptide binding]; other site
1097668018435	conserved gate region; other site
1097668018436	putative PBP binding loops; other site
1097668018437	ABC-ATPase subunit interface; other site
1097668018438	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1097668018439	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1097668018440	Walker A/P-loop; other site
1097668018441	ATP binding site [chemical binding]; other site
1097668018442	Q-loop/lid; other site
1097668018443	ABC transporter signature motif; other site
1097668018444	Walker B; other site
1097668018445	D-loop; other site
1097668018446	H-loop/switch region; other site
1097668018447	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1097668018448	putative Mg(2+) transport ATPase; Provisional; Region: PRK09977
1097668018449	MgtC family; Region: MgtC; pfam02308
1097668018450	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1097668018451	dimerization interface [polypeptide binding]; other site
1097668018452	putative active cleft [active]
1097668018453	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
1097668018454	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
1097668018455	dimer interface [polypeptide binding]; other site
1097668018456	ligand binding site [chemical binding]; other site
1097668018457	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668018458	dimerization interface [polypeptide binding]; other site
1097668018459	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668018460	dimer interface [polypeptide binding]; other site
1097668018461	putative CheW interface [polypeptide binding]; other site
1097668018462	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1097668018463	CoenzymeA binding site [chemical binding]; other site
1097668018464	subunit interaction site [polypeptide binding]; other site
1097668018465	PHB binding site; other site
1097668018466	putative arabinose transporter; Provisional; Region: PRK03545
1097668018467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018468	putative substrate translocation pore; other site
1097668018469	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668018470	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668018471	short chain dehydrogenase; Provisional; Region: PRK06138
1097668018472	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
1097668018473	NAD binding site [chemical binding]; other site
1097668018474	homotetramer interface [polypeptide binding]; other site
1097668018475	homodimer interface [polypeptide binding]; other site
1097668018476	active site
1097668018477	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668018478	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668018479	active site
1097668018480	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668018481	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668018482	active site
1097668018483	catalytic tetrad [active]
1097668018484	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1097668018485	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1097668018486	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668018487	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668018488	TM-ABC transporter signature motif; other site
1097668018489	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668018490	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668018491	Walker A/P-loop; other site
1097668018492	ATP binding site [chemical binding]; other site
1097668018493	Q-loop/lid; other site
1097668018494	ABC transporter signature motif; other site
1097668018495	Walker B; other site
1097668018496	D-loop; other site
1097668018497	H-loop/switch region; other site
1097668018498	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668018499	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1097668018500	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1097668018501	ligand binding site [chemical binding]; other site
1097668018502	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668018503	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668018504	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668018505	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
1097668018506	CoA binding domain; Region: CoA_binding_2; pfam13380
1097668018507	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1097668018508	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1097668018509	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097668018510	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097668018511	ParA-like protein; Provisional; Region: PHA02518
1097668018512	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668018513	P-loop; other site
1097668018514	Magnesium ion binding site [ion binding]; other site
1097668018515	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1097668018516	ParB-like nuclease domain; Region: ParB; smart00470
1097668018517	Initiator Replication protein; Region: Rep_3; pfam01051
1097668018518	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1097668018519	Domain found in IF2B/IF5; Region: eIF-5_eIF-2B; cl17014
1097668018520	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668018521	active site
1097668018522	catalytic residues [active]
1097668018523	Int/Topo IB signature motif; other site
1097668018524	DNA binding site [nucleotide binding]
1097668018525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1097668018526	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1097668018527	Protein of unknown function (DUF2471); Region: DUF2471; pfam10616
1097668018528	CsbD-like; Region: CsbD; pfam05532
1097668018529	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1097668018530	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668018531	non-specific DNA binding site [nucleotide binding]; other site
1097668018532	salt bridge; other site
1097668018533	sequence-specific DNA binding site [nucleotide binding]; other site
1097668018534	Cupin domain; Region: Cupin_2; pfam07883
1097668018535	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1097668018536	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1097668018537	substrate-cofactor binding pocket; other site
1097668018538	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668018539	catalytic residue [active]
1097668018540	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1097668018541	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1097668018542	NAD(P) binding site [chemical binding]; other site
1097668018543	YceI-like domain; Region: YceI; smart00867
1097668018544	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
1097668018545	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1097668018546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668018547	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1097668018548	NAD(P) binding site [chemical binding]; other site
1097668018549	active site
1097668018550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668018551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668018552	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1097668018553	putative substrate binding pocket [chemical binding]; other site
1097668018554	putative dimerization interface [polypeptide binding]; other site
1097668018555	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791
1097668018556	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668018557	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668018558	dimerization interface [polypeptide binding]; other site
1097668018559	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1097668018560	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1097668018561	metal binding site [ion binding]; metal-binding site
1097668018562	putative dimer interface [polypeptide binding]; other site
1097668018563	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018564	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668018565	putative substrate translocation pore; other site
1097668018566	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1097668018567	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668018568	inhibitor site; inhibition site
1097668018569	active site
1097668018570	dimer interface [polypeptide binding]; other site
1097668018571	catalytic residue [active]
1097668018572	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668018573	MarR family; Region: MarR_2; pfam12802
1097668018574	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1097668018575	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668018576	Coenzyme A binding pocket [chemical binding]; other site
1097668018577	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1097668018578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018579	active site
1097668018580	phosphorylation site [posttranslational modification]
1097668018581	intermolecular recognition site; other site
1097668018582	dimerization interface [polypeptide binding]; other site
1097668018583	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668018584	DNA binding site [nucleotide binding]
1097668018585	sensor protein QseC; Provisional; Region: PRK10337
1097668018586	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668018587	dimer interface [polypeptide binding]; other site
1097668018588	phosphorylation site [posttranslational modification]
1097668018589	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018590	ATP binding site [chemical binding]; other site
1097668018591	Mg2+ binding site [ion binding]; other site
1097668018592	G-X-G motif; other site
1097668018593	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668018594	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668018595	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668018596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668018597	S-adenosylmethionine binding site [chemical binding]; other site
1097668018598	Cupin; Region: Cupin_6; pfam12852
1097668018599	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668018600	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668018601	MarR family; Region: MarR_2; pfam12802
1097668018602	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668018603	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1097668018604	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668018605	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668018606	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668018607	putative effector binding pocket; other site
1097668018608	dimerization interface [polypeptide binding]; other site
1097668018609	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018610	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668018611	putative substrate translocation pore; other site
1097668018612	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1097668018613	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668018614	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668018615	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1097668018616	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1097668018617	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1097668018618	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668018619	Ligand Binding Site [chemical binding]; other site
1097668018620	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1097668018621	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1097668018622	putative active site [active]
1097668018623	putative metal binding site [ion binding]; other site
1097668018624	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668018625	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1097668018626	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1097668018627	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668018628	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1097668018629	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1097668018630	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1097668018631	transcriptional regulator; Provisional; Region: PRK10632
1097668018632	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668018633	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1097668018634	putative effector binding pocket; other site
1097668018635	putative dimerization interface [polypeptide binding]; other site
1097668018636	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1097668018637	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1097668018638	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668018639	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1097668018640	FAD binding pocket [chemical binding]; other site
1097668018641	FAD binding motif [chemical binding]; other site
1097668018642	phosphate binding motif [ion binding]; other site
1097668018643	beta-alpha-beta structure motif; other site
1097668018644	NAD binding pocket [chemical binding]; other site
1097668018645	Heme binding  pocket [chemical binding]; other site
1097668018646	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668018647	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668018648	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1097668018649	putative C-terminal domain interface [polypeptide binding]; other site
1097668018650	putative GSH binding site (G-site) [chemical binding]; other site
1097668018651	putative dimer interface [polypeptide binding]; other site
1097668018652	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
1097668018653	putative N-terminal domain interface [polypeptide binding]; other site
1097668018654	putative dimer interface [polypeptide binding]; other site
1097668018655	putative substrate binding pocket (H-site) [chemical binding]; other site
1097668018656	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1097668018657	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1097668018658	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1097668018659	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668018660	PAS domain; Region: PAS_9; pfam13426
1097668018661	putative active site [active]
1097668018662	heme pocket [chemical binding]; other site
1097668018663	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1097668018664	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1097668018665	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668018666	dimer interface [polypeptide binding]; other site
1097668018667	putative CheW interface [polypeptide binding]; other site
1097668018668	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1097668018669	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668018670	NAD(P) binding site [chemical binding]; other site
1097668018671	active site
1097668018672	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1097668018673	PAS fold; Region: PAS_4; pfam08448
1097668018674	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1097668018675	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668018676	Walker B motif; other site
1097668018677	arginine finger; other site
1097668018678	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668018679	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1097668018680	Predicted permeases [General function prediction only]; Region: COG0679
1097668018681	Predicted flavoprotein [General function prediction only]; Region: COG0431
1097668018682	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668018683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668018684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018685	ATP binding site [chemical binding]; other site
1097668018686	Mg2+ binding site [ion binding]; other site
1097668018687	G-X-G motif; other site
1097668018688	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668018689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018690	active site
1097668018691	phosphorylation site [posttranslational modification]
1097668018692	intermolecular recognition site; other site
1097668018693	dimerization interface [polypeptide binding]; other site
1097668018694	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668018695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018696	active site
1097668018697	phosphorylation site [posttranslational modification]
1097668018698	intermolecular recognition site; other site
1097668018699	dimerization interface [polypeptide binding]; other site
1097668018700	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1097668018701	Chemotaxis phosphatase CheX; Region: CheX; cl15816
1097668018702	PAS fold; Region: PAS; pfam00989
1097668018703	PAS domain; Region: PAS; smart00091
1097668018704	putative active site [active]
1097668018705	heme pocket [chemical binding]; other site
1097668018706	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668018707	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668018708	metal binding site [ion binding]; metal-binding site
1097668018709	active site
1097668018710	I-site; other site
1097668018711	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1097668018712	active site lid residues [active]
1097668018713	substrate binding pocket [chemical binding]; other site
1097668018714	catalytic residues [active]
1097668018715	substrate-Mg2+ binding site; other site
1097668018716	aspartate-rich region 1; other site
1097668018717	aspartate-rich region 2; other site
1097668018718	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668018719	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
1097668018720	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1097668018721	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1097668018722	Active site cavity [active]
1097668018723	catalytic acid [active]
1097668018724	hypothetical protein; Provisional; Region: PRK07077
1097668018725	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1097668018726	VacJ like lipoprotein; Region: VacJ; cl01073
1097668018727	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
1097668018728	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1097668018729	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668018730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018731	active site
1097668018732	phosphorylation site [posttranslational modification]
1097668018733	intermolecular recognition site; other site
1097668018734	dimerization interface [polypeptide binding]; other site
1097668018735	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668018736	DNA binding residues [nucleotide binding]
1097668018737	dimerization interface [polypeptide binding]; other site
1097668018738	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
1097668018739	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1097668018740	Histidine kinase; Region: HisKA_3; pfam07730
1097668018741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018742	ATP binding site [chemical binding]; other site
1097668018743	Mg2+ binding site [ion binding]; other site
1097668018744	G-X-G motif; other site
1097668018745	carbon starvation protein A; Provisional; Region: PRK15015
1097668018746	Carbon starvation protein CstA; Region: CstA; pfam02554
1097668018747	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1097668018748	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1097668018749	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1097668018750	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1097668018751	putative active site [active]
1097668018752	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
1097668018753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668018754	FeS/SAM binding site; other site
1097668018755	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
1097668018756	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1097668018757	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1097668018758	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1097668018759	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1097668018760	DXD motif; other site
1097668018761	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1097668018762	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1097668018763	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1097668018764	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
1097668018765	putative NADP binding site [chemical binding]; other site
1097668018766	putative substrate binding site [chemical binding]; other site
1097668018767	active site
1097668018768	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097668018769	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1097668018770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668018771	dimer interface [polypeptide binding]; other site
1097668018772	phosphorylation site [posttranslational modification]
1097668018773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018774	ATP binding site [chemical binding]; other site
1097668018775	Mg2+ binding site [ion binding]; other site
1097668018776	G-X-G motif; other site
1097668018777	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668018778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018779	active site
1097668018780	phosphorylation site [posttranslational modification]
1097668018781	intermolecular recognition site; other site
1097668018782	dimerization interface [polypeptide binding]; other site
1097668018783	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668018784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018785	active site
1097668018786	phosphorylation site [posttranslational modification]
1097668018787	intermolecular recognition site; other site
1097668018788	dimerization interface [polypeptide binding]; other site
1097668018789	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668018790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018791	active site
1097668018792	phosphorylation site [posttranslational modification]
1097668018793	intermolecular recognition site; other site
1097668018794	dimerization interface [polypeptide binding]; other site
1097668018795	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1097668018796	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1097668018797	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1097668018798	CheB methylesterase; Region: CheB_methylest; pfam01339
1097668018799	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668018800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668018801	active site
1097668018802	phosphorylation site [posttranslational modification]
1097668018803	intermolecular recognition site; other site
1097668018804	dimerization interface [polypeptide binding]; other site
1097668018805	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668018806	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668018807	dimer interface [polypeptide binding]; other site
1097668018808	phosphorylation site [posttranslational modification]
1097668018809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018810	ATP binding site [chemical binding]; other site
1097668018811	Mg2+ binding site [ion binding]; other site
1097668018812	G-X-G motif; other site
1097668018813	acylphosphatase; Provisional; Region: PRK14424
1097668018814	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
1097668018815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668018816	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1097668018817	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1097668018818	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1097668018819	Protein of unknown function (DUF962); Region: DUF962; cl01879
1097668018820	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1097668018821	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668018822	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668018823	catalytic residue [active]
1097668018824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018825	putative transporter; Provisional; Region: PRK10504
1097668018826	putative substrate translocation pore; other site
1097668018827	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
1097668018828	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1097668018829	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1097668018830	HSP70 interaction site [polypeptide binding]; other site
1097668018831	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1097668018832	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668018833	active site
1097668018834	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1097668018835	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1097668018836	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1097668018837	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668018838	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668018839	ligand binding site [chemical binding]; other site
1097668018840	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
1097668018841	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1097668018842	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1097668018843	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1097668018844	structural tetrad; other site
1097668018845	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1097668018846	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668018847	N-terminal plug; other site
1097668018848	ligand-binding site [chemical binding]; other site
1097668018849	Histidine kinase; Region: HisKA_3; pfam07730
1097668018850	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668018851	ATP binding site [chemical binding]; other site
1097668018852	Mg2+ binding site [ion binding]; other site
1097668018853	G-X-G motif; other site
1097668018854	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1097668018855	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668018856	FeS/SAM binding site; other site
1097668018857	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1097668018858	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1097668018859	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1097668018860	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1097668018861	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
1097668018862	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1097668018863	FwdC/FmdC. This domain of unknown function is found in the subunit C of formylmethanofuran dehydrogenase, an enzyme that catalyzes the first step in methane formation from CO2 in methanogenic archaea, hyperthermophiles and bacteria. There are two...; Region: FwdC/FmdC; cd00980
1097668018864	putative subunit interface; other site
1097668018865	formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114
1097668018866	Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913
1097668018867	FTR, proximal lobe; Region: FTR_C; pfam02741
1097668018868	formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121
1097668018869	Formylmethanofuran dehydrogenase (FMDH) subunit A; Methanogenic bacteria and archea derive the energy for autotrophic growth from methanogenesis, the reduction of CO2 with molecular hydrogen as the electron donor. FMDH catalyzes the first step in...; Region: FMDH_A; cd01304
1097668018870	active site
1097668018871	The MopB_FmdB-FwdB CD contains the molybdenum/tungsten formylmethanofuran dehydrogenases, subunit B (FmdB/FwdB), and other related proteins. Formylmethanofuran dehydrogenase catalyzes the first step in methane formation from CO2 in methanogenic archaea...; Region: MopB_FmdB-FwdB; cd02761
1097668018872	formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129
1097668018873	putative [4Fe-4S] binding site [ion binding]; other site
1097668018874	putative molybdopterin cofactor binding site [chemical binding]; other site
1097668018875	hisA/hisF family protein; Region: hisAF_rel; TIGR00734
1097668018876	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
1097668018877	active site
1097668018878	Predicted ATP-utilizing enzyme (ATP-grasp superfamily) [General function prediction only]; Region: COG1821
1097668018879	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668018880	Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668
1097668018881	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1097668018882	nucleotide binding site [chemical binding]; other site
1097668018883	substrate binding site [chemical binding]; other site
1097668018884	hypothetical protein; Provisional; Region: PRK02227
1097668018885	Protein of unknown function (DUF447); Region: DUF447; pfam04289
1097668018886	ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208
1097668018887	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
1097668018888	homodimer interface [polypeptide binding]; other site
1097668018889	active site
1097668018890	heterodimer interface [polypeptide binding]; other site
1097668018891	catalytic residue [active]
1097668018892	metal binding site [ion binding]; metal-binding site
1097668018893	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
1097668018894	multimerization interface [polypeptide binding]; other site
1097668018895	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
1097668018896	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668018897	Walker A motif; other site
1097668018898	ATP binding site [chemical binding]; other site
1097668018899	Walker B motif; other site
1097668018900	arginine finger; other site
1097668018901	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1097668018902	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1097668018903	AMP binding site [chemical binding]; other site
1097668018904	metal binding site [ion binding]; metal-binding site
1097668018905	active site
1097668018906	phosphoribulokinase; Provisional; Region: PRK15453
1097668018907	transketolase; Reviewed; Region: PRK12753
1097668018908	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1097668018909	TPP-binding site [chemical binding]; other site
1097668018910	dimer interface [polypeptide binding]; other site
1097668018911	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097668018912	PYR/PP interface [polypeptide binding]; other site
1097668018913	dimer interface [polypeptide binding]; other site
1097668018914	TPP binding site [chemical binding]; other site
1097668018915	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668018916	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1097668018917	intersubunit interface [polypeptide binding]; other site
1097668018918	active site
1097668018919	zinc binding site [ion binding]; other site
1097668018920	Na+ binding site [ion binding]; other site
1097668018921	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1097668018922	putative active site [active]
1097668018923	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1097668018924	putative catalytic residue [active]
1097668018925	dihydropteroate synthase-related protein; Region: TIGR00284
1097668018926	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1097668018927	substrate binding pocket [chemical binding]; other site
1097668018928	dimer interface [polypeptide binding]; other site
1097668018929	inhibitor binding site; inhibition site
1097668018930	Archaeal flavoproteins [Energy production and conversion]; Region: COG1036
1097668018931	Flavoprotein; Region: Flavoprotein; pfam02441
1097668018932	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1097668018933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668018934	Walker A motif; other site
1097668018935	ATP binding site [chemical binding]; other site
1097668018936	Walker B motif; other site
1097668018937	arginine finger; other site
1097668018938	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668018939	Dihydroneopterin aldolase; Region: FolB; smart00905
1097668018940	active site
1097668018941	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
1097668018942	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874
1097668018943	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
1097668018944	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668018945	N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264
1097668018946	Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria.  It catalyzes the reversible formation of N(5), N...; Region: MCH; cd00545
1097668018947	trimer interface I [polypeptide binding]; other site
1097668018948	putative substrate binding pocket [chemical binding]; other site
1097668018949	trimer interface II [polypeptide binding]; other site
1097668018950	Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232
1097668018951	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1097668018952	Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176
1097668018953	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1097668018954	NAD(P) binding pocket [chemical binding]; other site
1097668018955	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
1097668018956	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1097668018957	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1097668018958	aromatic arch; other site
1097668018959	DCoH dimer interaction site [polypeptide binding]; other site
1097668018960	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1097668018961	DCoH tetramer interaction site [polypeptide binding]; other site
1097668018962	substrate binding site [chemical binding]; other site
1097668018963	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1097668018964	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
1097668018965	Trp docking motif [polypeptide binding]; other site
1097668018966	dimer interface [polypeptide binding]; other site
1097668018967	active site
1097668018968	small subunit binding site [polypeptide binding]; other site
1097668018969	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1097668018970	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
1097668018971	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668018972	substrate binding pocket [chemical binding]; other site
1097668018973	membrane-bound complex binding site; other site
1097668018974	hinge residues; other site
1097668018975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668018976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668018977	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1097668018978	putative dimerization interface [polypeptide binding]; other site
1097668018979	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668018980	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
1097668018981	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
1097668018982	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668018983	EthD domain; Region: EthD; cl17553
1097668018984	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668018985	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668018986	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668018987	putative substrate translocation pore; other site
1097668018988	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
1097668018989	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
1097668018990	NAD binding site [chemical binding]; other site
1097668018991	catalytic Zn binding site [ion binding]; other site
1097668018992	structural Zn binding site [ion binding]; other site
1097668018993	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1097668018994	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1097668018995	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1097668018996	active site
1097668018997	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668018998	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668018999	DNA-binding site [nucleotide binding]; DNA binding site
1097668019000	FCD domain; Region: FCD; pfam07729
1097668019001	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668019002	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668019003	inhibitor site; inhibition site
1097668019004	active site
1097668019005	dimer interface [polypeptide binding]; other site
1097668019006	catalytic residue [active]
1097668019007	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668019008	FAD dependent oxidoreductase; Region: DAO; pfam01266
1097668019009	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668019010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019011	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668019012	dimerization interface [polypeptide binding]; other site
1097668019013	substrate binding pocket [chemical binding]; other site
1097668019014	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1097668019015	EamA-like transporter family; Region: EamA; pfam00892
1097668019016	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
1097668019017	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097668019018	putative NAD(P) binding site [chemical binding]; other site
1097668019019	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668019020	Mandelate racemase / muconate lactonizing enzyme, N-terminal domain; Region: MR_MLE_N; pfam02746
1097668019021	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cd00308
1097668019022	metal binding site [ion binding]; metal-binding site
1097668019023	substrate binding pocket [chemical binding]; other site
1097668019024	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1097668019025	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1097668019026	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
1097668019027	putative hydrophobic ligand binding site [chemical binding]; other site
1097668019028	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
1097668019029	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668019030	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668019031	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668019032	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1097668019033	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1097668019034	Walker A/P-loop; other site
1097668019035	ATP binding site [chemical binding]; other site
1097668019036	Q-loop/lid; other site
1097668019037	ABC transporter signature motif; other site
1097668019038	Walker B; other site
1097668019039	D-loop; other site
1097668019040	H-loop/switch region; other site
1097668019041	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
1097668019042	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1097668019043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019044	dimer interface [polypeptide binding]; other site
1097668019045	conserved gate region; other site
1097668019046	ABC-ATPase subunit interface; other site
1097668019047	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1097668019048	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1097668019049	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1097668019050	putative active site [active]
1097668019051	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
1097668019052	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
1097668019053	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668019054	Walker A/P-loop; other site
1097668019055	ATP binding site [chemical binding]; other site
1097668019056	Q-loop/lid; other site
1097668019057	ABC transporter signature motif; other site
1097668019058	Walker B; other site
1097668019059	D-loop; other site
1097668019060	H-loop/switch region; other site
1097668019061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019062	dimer interface [polypeptide binding]; other site
1097668019063	conserved gate region; other site
1097668019064	putative PBP binding loops; other site
1097668019065	ABC-ATPase subunit interface; other site
1097668019066	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
1097668019067	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668019068	substrate binding pocket [chemical binding]; other site
1097668019069	membrane-bound complex binding site; other site
1097668019070	hinge residues; other site
1097668019071	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1097668019072	AAA domain; Region: AAA_18; pfam13238
1097668019073	active site
1097668019074	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
1097668019075	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
1097668019076	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668019077	DNA-binding site [nucleotide binding]; DNA binding site
1097668019078	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1097668019079	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
1097668019080	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
1097668019081	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
1097668019082	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
1097668019083	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
1097668019084	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668019085	Walker A/P-loop; other site
1097668019086	ATP binding site [chemical binding]; other site
1097668019087	Q-loop/lid; other site
1097668019088	ABC transporter signature motif; other site
1097668019089	Walker B; other site
1097668019090	D-loop; other site
1097668019091	H-loop/switch region; other site
1097668019092	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668019093	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
1097668019094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668019095	Walker A/P-loop; other site
1097668019096	ATP binding site [chemical binding]; other site
1097668019097	Q-loop/lid; other site
1097668019098	ABC transporter signature motif; other site
1097668019099	Walker B; other site
1097668019100	D-loop; other site
1097668019101	H-loop/switch region; other site
1097668019102	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
1097668019103	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668019104	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
1097668019105	active site
1097668019106	benzoate transport; Region: 2A0115; TIGR00895
1097668019107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019108	putative substrate translocation pore; other site
1097668019109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019110	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1097668019111	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1097668019112	dimerization interface [polypeptide binding]; other site
1097668019113	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668019114	dimer interface [polypeptide binding]; other site
1097668019115	putative CheW interface [polypeptide binding]; other site
1097668019116	Beta-lactamase; Region: Beta-lactamase; pfam00144
1097668019117	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097668019118	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1097668019119	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
1097668019120	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668019121	putative metal binding site [ion binding]; other site
1097668019122	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668019123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019124	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
1097668019125	putative dimerization interface [polypeptide binding]; other site
1097668019126	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668019127	Predicted ATPase [General function prediction only]; Region: COG3910
1097668019128	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668019129	Walker A/P-loop; other site
1097668019130	ATP binding site [chemical binding]; other site
1097668019131	Q-loop/lid; other site
1097668019132	ABC transporter signature motif; other site
1097668019133	Walker B; other site
1097668019134	D-loop; other site
1097668019135	H-loop/switch region; other site
1097668019136	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668019137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019139	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668019140	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1097668019141	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668019142	dimer interface [polypeptide binding]; other site
1097668019143	phosphorylation site [posttranslational modification]
1097668019144	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668019145	ATP binding site [chemical binding]; other site
1097668019146	Mg2+ binding site [ion binding]; other site
1097668019147	G-X-G motif; other site
1097668019148	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668019149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019150	active site
1097668019151	phosphorylation site [posttranslational modification]
1097668019152	intermolecular recognition site; other site
1097668019153	dimerization interface [polypeptide binding]; other site
1097668019154	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668019155	DNA binding site [nucleotide binding]
1097668019156	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1097668019157	active site
1097668019158	DNA polymerase IV; Validated; Region: PRK02406
1097668019159	DNA binding site [nucleotide binding]
1097668019160	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1097668019161	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1097668019162	active site
1097668019163	iron coordination sites [ion binding]; other site
1097668019164	substrate binding pocket [chemical binding]; other site
1097668019165	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668019166	NMT1-like family; Region: NMT1_2; pfam13379
1097668019167	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668019168	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668019169	Walker A/P-loop; other site
1097668019170	ATP binding site [chemical binding]; other site
1097668019171	Q-loop/lid; other site
1097668019172	ABC transporter signature motif; other site
1097668019173	Walker B; other site
1097668019174	D-loop; other site
1097668019175	H-loop/switch region; other site
1097668019176	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668019177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019178	putative PBP binding loops; other site
1097668019179	dimer interface [polypeptide binding]; other site
1097668019180	ABC-ATPase subunit interface; other site
1097668019181	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668019182	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019183	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1097668019184	putative effector binding pocket; other site
1097668019185	putative dimerization interface [polypeptide binding]; other site
1097668019186	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668019187	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668019188	active site
1097668019189	catalytic tetrad [active]
1097668019190	drug efflux system protein MdtG; Provisional; Region: PRK09874
1097668019191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019192	putative substrate translocation pore; other site
1097668019193	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1097668019194	putative catalytic site [active]
1097668019195	putative phosphate binding site [ion binding]; other site
1097668019196	active site
1097668019197	metal binding site A [ion binding]; metal-binding site
1097668019198	DNA binding site [nucleotide binding]
1097668019199	putative AP binding site [nucleotide binding]; other site
1097668019200	putative metal binding site B [ion binding]; other site
1097668019201	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1097668019202	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668019203	xanthine permease; Region: pbuX; TIGR03173
1097668019204	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668019205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019206	active site
1097668019207	phosphorylation site [posttranslational modification]
1097668019208	intermolecular recognition site; other site
1097668019209	dimerization interface [polypeptide binding]; other site
1097668019210	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
1097668019211	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1097668019212	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1097668019213	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1097668019214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1097668019215	ATP binding site [chemical binding]; other site
1097668019216	Mg2+ binding site [ion binding]; other site
1097668019217	G-X-G motif; other site
1097668019218	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1097668019219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668019220	ATP binding site [chemical binding]; other site
1097668019221	Mg2+ binding site [ion binding]; other site
1097668019222	G-X-G motif; other site
1097668019223	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1097668019224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1097668019225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668019226	dimer interface [polypeptide binding]; other site
1097668019227	phosphorylation site [posttranslational modification]
1097668019228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668019229	ATP binding site [chemical binding]; other site
1097668019230	Mg2+ binding site [ion binding]; other site
1097668019231	G-X-G motif; other site
1097668019232	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668019233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019234	active site
1097668019235	phosphorylation site [posttranslational modification]
1097668019236	intermolecular recognition site; other site
1097668019237	dimerization interface [polypeptide binding]; other site
1097668019238	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668019239	putative active site [active]
1097668019240	heme pocket [chemical binding]; other site
1097668019241	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668019242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668019243	dimer interface [polypeptide binding]; other site
1097668019244	phosphorylation site [posttranslational modification]
1097668019245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668019246	ATP binding site [chemical binding]; other site
1097668019247	Mg2+ binding site [ion binding]; other site
1097668019248	G-X-G motif; other site
1097668019249	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668019250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019251	active site
1097668019252	phosphorylation site [posttranslational modification]
1097668019253	intermolecular recognition site; other site
1097668019254	dimerization interface [polypeptide binding]; other site
1097668019255	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668019256	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668019257	DNA-binding site [nucleotide binding]; DNA binding site
1097668019258	FCD domain; Region: FCD; pfam07729
1097668019259	short chain dehydrogenase; Provisional; Region: PRK12829
1097668019260	classical (c) SDRs; Region: SDR_c; cd05233
1097668019261	NAD(P) binding site [chemical binding]; other site
1097668019262	active site
1097668019263	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1097668019264	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668019265	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668019266	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1097668019267	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668019268	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668019269	Walker A/P-loop; other site
1097668019270	ATP binding site [chemical binding]; other site
1097668019271	Q-loop/lid; other site
1097668019272	ABC transporter signature motif; other site
1097668019273	Walker B; other site
1097668019274	D-loop; other site
1097668019275	H-loop/switch region; other site
1097668019276	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668019277	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668019278	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668019279	TM-ABC transporter signature motif; other site
1097668019280	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668019281	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668019282	TM-ABC transporter signature motif; other site
1097668019283	3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129
1097668019284	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668019285	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668019286	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097668019287	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668019288	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1097668019289	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1097668019290	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1097668019291	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1097668019292	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1097668019293	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1097668019294	Walker A/P-loop; other site
1097668019295	ATP binding site [chemical binding]; other site
1097668019296	Q-loop/lid; other site
1097668019297	ABC transporter signature motif; other site
1097668019298	Walker B; other site
1097668019299	D-loop; other site
1097668019300	H-loop/switch region; other site
1097668019301	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668019302	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668019303	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
1097668019304	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1097668019305	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1097668019306	Domain of unknown function (DUF756); Region: DUF756; pfam05506
1097668019307	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1097668019308	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1097668019309	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1097668019310	active site
1097668019311	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668019312	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1097668019313	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019314	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1097668019315	putative dimerization interface [polypeptide binding]; other site
1097668019316	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
1097668019317	heat shock protein HtpX; Provisional; Region: PRK05457
1097668019318	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668019319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019320	active site
1097668019321	phosphorylation site [posttranslational modification]
1097668019322	intermolecular recognition site; other site
1097668019323	dimerization interface [polypeptide binding]; other site
1097668019324	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668019325	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668019326	dimer interface [polypeptide binding]; other site
1097668019327	phosphorylation site [posttranslational modification]
1097668019328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668019329	ATP binding site [chemical binding]; other site
1097668019330	Mg2+ binding site [ion binding]; other site
1097668019331	G-X-G motif; other site
1097668019332	Integrase core domain; Region: rve; pfam00665
1097668019333	transposase; Validated; Region: PRK08181
1097668019334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668019335	Walker A motif; other site
1097668019336	ATP binding site [chemical binding]; other site
1097668019337	TIR domain; Region: TIR_2; pfam13676
1097668019338	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668019339	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668019340	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1097668019341	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1097668019342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1097668019343	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
1097668019344	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1097668019345	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1097668019346	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1097668019347	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
1097668019348	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1097668019349	active site
1097668019350	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019351	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668019352	putative substrate translocation pore; other site
1097668019353	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668019354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668019355	NAD(P) binding site [chemical binding]; other site
1097668019356	active site
1097668019357	enoyl-CoA hydratase; Provisional; Region: PRK06494
1097668019358	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668019359	substrate binding site [chemical binding]; other site
1097668019360	oxyanion hole (OAH) forming residues; other site
1097668019361	trimer interface [polypeptide binding]; other site
1097668019362	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668019363	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019364	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668019365	dimerization interface [polypeptide binding]; other site
1097668019366	substrate binding pocket [chemical binding]; other site
1097668019367	PAS domain S-box; Region: sensory_box; TIGR00229
1097668019368	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668019369	putative active site [active]
1097668019370	heme pocket [chemical binding]; other site
1097668019371	PAS domain S-box; Region: sensory_box; TIGR00229
1097668019372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668019373	putative active site [active]
1097668019374	heme pocket [chemical binding]; other site
1097668019375	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668019376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668019377	dimer interface [polypeptide binding]; other site
1097668019378	phosphorylation site [posttranslational modification]
1097668019379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668019380	ATP binding site [chemical binding]; other site
1097668019381	Mg2+ binding site [ion binding]; other site
1097668019382	G-X-G motif; other site
1097668019383	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668019384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019385	active site
1097668019386	phosphorylation site [posttranslational modification]
1097668019387	intermolecular recognition site; other site
1097668019388	dimerization interface [polypeptide binding]; other site
1097668019389	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668019390	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668019391	DNA-binding site [nucleotide binding]; DNA binding site
1097668019392	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668019393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668019394	homodimer interface [polypeptide binding]; other site
1097668019395	catalytic residue [active]
1097668019396	DJ-1 family protein; Region: not_thiJ; TIGR01383
1097668019397	Putative amidotransferase; Region: DUF4066; pfam13278
1097668019398	conserved cys residue [active]
1097668019399	proline/glycine betaine transporter; Provisional; Region: PRK10642
1097668019400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019401	putative substrate translocation pore; other site
1097668019402	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668019403	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1097668019404	peptide binding site [polypeptide binding]; other site
1097668019405	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668019406	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1097668019407	acyl-activating enzyme (AAE) consensus motif; other site
1097668019408	AMP binding site [chemical binding]; other site
1097668019409	active site
1097668019410	CoA binding site [chemical binding]; other site
1097668019411	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1097668019412	homotrimer interaction site [polypeptide binding]; other site
1097668019413	putative active site [active]
1097668019414	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097668019415	active site
1097668019416	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668019417	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668019418	active site
1097668019419	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668019420	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668019421	substrate binding site [chemical binding]; other site
1097668019422	oxyanion hole (OAH) forming residues; other site
1097668019423	trimer interface [polypeptide binding]; other site
1097668019424	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668019425	MarR family; Region: MarR; pfam01047
1097668019426	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668019427	classical (c) SDRs; Region: SDR_c; cd05233
1097668019428	NAD(P) binding site [chemical binding]; other site
1097668019429	active site
1097668019430	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
1097668019431	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668019432	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1097668019433	active site
1097668019434	FMN binding site [chemical binding]; other site
1097668019435	substrate binding site [chemical binding]; other site
1097668019436	homotetramer interface [polypeptide binding]; other site
1097668019437	catalytic residue [active]
1097668019438	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1097668019439	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1097668019440	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668019441	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1097668019442	FAD binding pocket [chemical binding]; other site
1097668019443	FAD binding motif [chemical binding]; other site
1097668019444	phosphate binding motif [ion binding]; other site
1097668019445	beta-alpha-beta structure motif; other site
1097668019446	NAD binding pocket [chemical binding]; other site
1097668019447	Heme binding  pocket [chemical binding]; other site
1097668019448	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668019449	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668019450	catalytic loop [active]
1097668019451	iron binding site [ion binding]; other site
1097668019452	Hemerythrin; Region: Hemerythrin; cd12107
1097668019453	Fe binding site [ion binding]; other site
1097668019454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668019455	DNA-binding site [nucleotide binding]; DNA binding site
1097668019456	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668019457	FCD domain; Region: FCD; pfam07729
1097668019458	gluconate 5-dehydrogenase; Provisional; Region: PRK08085
1097668019459	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1097668019460	NADP binding site [chemical binding]; other site
1097668019461	homodimer interface [polypeptide binding]; other site
1097668019462	active site
1097668019463	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019464	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668019465	putative substrate translocation pore; other site
1097668019466	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1097668019467	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
1097668019468	metal binding site [ion binding]; metal-binding site
1097668019469	substrate binding pocket [chemical binding]; other site
1097668019470	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1097668019471	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1097668019472	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
1097668019473	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668019474	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097668019475	non-specific DNA interactions [nucleotide binding]; other site
1097668019476	DNA binding site [nucleotide binding]
1097668019477	sequence specific DNA binding site [nucleotide binding]; other site
1097668019478	putative cAMP binding site [chemical binding]; other site
1097668019479	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668019480	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1097668019481	active site
1097668019482	catalytic residues [active]
1097668019483	metal binding site [ion binding]; metal-binding site
1097668019484	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668019485	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668019486	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668019487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019488	putative substrate translocation pore; other site
1097668019489	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668019490	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668019491	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668019492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019493	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668019494	dimerization interface [polypeptide binding]; other site
1097668019495	amidase; Provisional; Region: PRK07486
1097668019496	Amidase; Region: Amidase; cl11426
1097668019497	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
1097668019498	benzoate transport; Region: 2A0115; TIGR00895
1097668019499	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019500	putative substrate translocation pore; other site
1097668019501	GAF domain; Region: GAF; pfam01590
1097668019502	benzoate transport; Region: 2A0115; TIGR00895
1097668019503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019504	putative substrate translocation pore; other site
1097668019505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019506	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1097668019507	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1097668019508	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668019509	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668019510	DNA-binding site [nucleotide binding]; DNA binding site
1097668019511	FCD domain; Region: FCD; pfam07729
1097668019512	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1097668019513	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1097668019514	dimer interface [polypeptide binding]; other site
1097668019515	PYR/PP interface [polypeptide binding]; other site
1097668019516	TPP binding site [chemical binding]; other site
1097668019517	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668019518	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1097668019519	TPP-binding site [chemical binding]; other site
1097668019520	dimer interface [polypeptide binding]; other site
1097668019521	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1097668019522	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1097668019523	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
1097668019524	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
1097668019525	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019526	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668019527	dimerization interface [polypeptide binding]; other site
1097668019528	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668019529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019530	active site
1097668019531	phosphorylation site [posttranslational modification]
1097668019532	intermolecular recognition site; other site
1097668019533	dimerization interface [polypeptide binding]; other site
1097668019534	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668019535	DNA binding site [nucleotide binding]
1097668019536	FcoT-like thioesterase domain; Region: FcoT; pfam10862
1097668019537	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1097668019538	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1097668019539	trimer interface [polypeptide binding]; other site
1097668019540	active site
1097668019541	dimer interface [polypeptide binding]; other site
1097668019542	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668019543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019544	putative substrate translocation pore; other site
1097668019545	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668019546	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668019547	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668019548	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
1097668019549	putative hydrophobic ligand binding site [chemical binding]; other site
1097668019550	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668019551	dimerization interface [polypeptide binding]; other site
1097668019552	putative DNA binding site [nucleotide binding]; other site
1097668019553	putative Zn2+ binding site [ion binding]; other site
1097668019554	short chain dehydrogenase; Provisional; Region: PRK06500
1097668019555	classical (c) SDRs; Region: SDR_c; cd05233
1097668019556	NAD(P) binding site [chemical binding]; other site
1097668019557	active site
1097668019558	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668019559	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019560	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668019561	dimerization interface [polypeptide binding]; other site
1097668019562	substrate binding pocket [chemical binding]; other site
1097668019563	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668019564	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668019565	DNA binding site [nucleotide binding]
1097668019566	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
1097668019567	putative dimerization interface [polypeptide binding]; other site
1097668019568	putative ligand binding site [chemical binding]; other site
1097668019569	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668019570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019571	dimer interface [polypeptide binding]; other site
1097668019572	conserved gate region; other site
1097668019573	putative PBP binding loops; other site
1097668019574	ABC-ATPase subunit interface; other site
1097668019575	NMT1/THI5 like; Region: NMT1; pfam09084
1097668019576	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1097668019577	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668019578	active site 2 [active]
1097668019579	active site 1 [active]
1097668019580	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668019581	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668019582	Walker A/P-loop; other site
1097668019583	ATP binding site [chemical binding]; other site
1097668019584	Q-loop/lid; other site
1097668019585	ABC transporter signature motif; other site
1097668019586	Walker B; other site
1097668019587	D-loop; other site
1097668019588	H-loop/switch region; other site
1097668019589	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668019590	enoyl-CoA hydratase; Provisional; Region: PRK07658
1097668019591	substrate binding site [chemical binding]; other site
1097668019592	oxyanion hole (OAH) forming residues; other site
1097668019593	trimer interface [polypeptide binding]; other site
1097668019594	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668019595	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668019596	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1097668019597	Coenzyme A transferase; Region: CoA_trans; smart00882
1097668019598	Coenzyme A transferase; Region: CoA_trans; cl17247
1097668019599	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1097668019600	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1097668019601	shikimate binding site; other site
1097668019602	NAD(P) binding site [chemical binding]; other site
1097668019603	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668019604	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668019605	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668019606	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668019607	NAD(P) binding site [chemical binding]; other site
1097668019608	active site
1097668019609	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
1097668019610	Coenzyme A transferase; Region: CoA_trans; smart00882
1097668019611	Coenzyme A transferase; Region: CoA_trans; cl17247
1097668019612	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668019613	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668019614	active site
1097668019615	catalytic tetrad [active]
1097668019616	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668019617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668019618	putative substrate translocation pore; other site
1097668019619	hypothetical protein; Provisional; Region: PRK06208
1097668019620	intersubunit interface [polypeptide binding]; other site
1097668019621	active site
1097668019622	Zn2+ binding site [ion binding]; other site
1097668019623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668019624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019625	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668019626	putative effector binding pocket; other site
1097668019627	dimerization interface [polypeptide binding]; other site
1097668019628	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1097668019629	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1097668019630	putative sugar binding sites [chemical binding]; other site
1097668019631	Q-X-W motif; other site
1097668019632	Kelch motif; Region: Kelch_6; pfam13964
1097668019633	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
1097668019634	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1097668019635	Cu(I) binding site [ion binding]; other site
1097668019636	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1097668019637	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1097668019638	active site
1097668019639	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
1097668019640	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668019641	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668019642	active site
1097668019643	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
1097668019644	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1097668019645	putative ligand binding site [chemical binding]; other site
1097668019646	putative NAD binding site [chemical binding]; other site
1097668019647	catalytic site [active]
1097668019648	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668019649	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668019650	DNA binding site [nucleotide binding]
1097668019651	domain linker motif; other site
1097668019652	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1097668019653	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
1097668019654	DctM-like transporters; Region: DctM; pfam06808
1097668019655	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1097668019656	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1097668019657	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1097668019658	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1097668019659	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668019660	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668019661	Walker A/P-loop; other site
1097668019662	ATP binding site [chemical binding]; other site
1097668019663	Q-loop/lid; other site
1097668019664	ABC transporter signature motif; other site
1097668019665	Walker B; other site
1097668019666	D-loop; other site
1097668019667	H-loop/switch region; other site
1097668019668	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668019669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019670	dimer interface [polypeptide binding]; other site
1097668019671	conserved gate region; other site
1097668019672	putative PBP binding loops; other site
1097668019673	ABC-ATPase subunit interface; other site
1097668019674	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668019675	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668019676	substrate binding pocket [chemical binding]; other site
1097668019677	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1097668019678	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1097668019679	putative oxidoreductase; Provisional; Region: PRK08275
1097668019680	L-aspartate oxidase; Provisional; Region: PRK06175
1097668019681	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1097668019682	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1097668019683	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668019684	DNA-binding site [nucleotide binding]; DNA binding site
1097668019685	UTRA domain; Region: UTRA; pfam07702
1097668019686	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
1097668019687	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668019688	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1097668019689	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1097668019690	catalytic residue [active]
1097668019691	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1097668019692	Helix-turn-helix domain; Region: HTH_18; pfam12833
1097668019693	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668019694	Protein of unknown function (DUF1479); Region: DUF1479; pfam07350
1097668019695	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1097668019696	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1097668019697	high affinity sulphate transporter 1; Region: sulP; TIGR00815
1097668019698	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1097668019699	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1097668019700	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668019701	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1097668019702	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1097668019703	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1097668019704	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668019705	Coenzyme A binding pocket [chemical binding]; other site
1097668019706	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1097668019707	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1097668019708	active site
1097668019709	non-prolyl cis peptide bond; other site
1097668019710	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1097668019711	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1097668019712	active site
1097668019713	iron coordination sites [ion binding]; other site
1097668019714	substrate binding pocket [chemical binding]; other site
1097668019715	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668019716	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1097668019717	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668019718	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668019719	Walker A/P-loop; other site
1097668019720	ATP binding site [chemical binding]; other site
1097668019721	Q-loop/lid; other site
1097668019722	ABC transporter signature motif; other site
1097668019723	Walker B; other site
1097668019724	D-loop; other site
1097668019725	H-loop/switch region; other site
1097668019726	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668019727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019728	dimer interface [polypeptide binding]; other site
1097668019729	conserved gate region; other site
1097668019730	putative PBP binding loops; other site
1097668019731	ABC-ATPase subunit interface; other site
1097668019732	Protein of unknown function (DUF3088); Region: DUF3088; pfam11287
1097668019733	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1097668019734	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668019735	substrate binding pocket [chemical binding]; other site
1097668019736	membrane-bound complex binding site; other site
1097668019737	hinge residues; other site
1097668019738	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668019739	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668019740	substrate binding pocket [chemical binding]; other site
1097668019741	membrane-bound complex binding site; other site
1097668019742	hinge residues; other site
1097668019743	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668019744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019745	dimer interface [polypeptide binding]; other site
1097668019746	conserved gate region; other site
1097668019747	putative PBP binding loops; other site
1097668019748	ABC-ATPase subunit interface; other site
1097668019749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019750	dimer interface [polypeptide binding]; other site
1097668019751	conserved gate region; other site
1097668019752	putative PBP binding loops; other site
1097668019753	ABC-ATPase subunit interface; other site
1097668019754	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1097668019755	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1097668019756	active site
1097668019757	non-prolyl cis peptide bond; other site
1097668019758	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1097668019759	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668019760	active site
1097668019761	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1097668019762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019763	dimer interface [polypeptide binding]; other site
1097668019764	conserved gate region; other site
1097668019765	putative PBP binding loops; other site
1097668019766	ABC-ATPase subunit interface; other site
1097668019767	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1097668019768	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019769	dimer interface [polypeptide binding]; other site
1097668019770	conserved gate region; other site
1097668019771	putative PBP binding loops; other site
1097668019772	ABC-ATPase subunit interface; other site
1097668019773	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1097668019774	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
1097668019775	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1097668019776	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668019777	Walker A/P-loop; other site
1097668019778	ATP binding site [chemical binding]; other site
1097668019779	Q-loop/lid; other site
1097668019780	ABC transporter signature motif; other site
1097668019781	Walker B; other site
1097668019782	D-loop; other site
1097668019783	H-loop/switch region; other site
1097668019784	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1097668019785	Walker A/P-loop; other site
1097668019786	ATP binding site [chemical binding]; other site
1097668019787	Q-loop/lid; other site
1097668019788	ABC transporter signature motif; other site
1097668019789	Walker B; other site
1097668019790	D-loop; other site
1097668019791	H-loop/switch region; other site
1097668019792	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1097668019793	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1097668019794	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1097668019795	active site
1097668019796	non-prolyl cis peptide bond; other site
1097668019797	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1097668019798	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668019799	active site
1097668019800	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668019801	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668019802	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668019803	dimerization interface [polypeptide binding]; other site
1097668019804	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1097668019805	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1097668019806	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1097668019807	active site
1097668019808	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1097668019809	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1097668019810	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
1097668019811	choline dehydrogenase; Validated; Region: PRK02106
1097668019812	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668019813	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668019814	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1097668019815	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1097668019816	MltA specific insert domain; Region: MltA; cl08398
1097668019817	3D domain; Region: 3D; pfam06725
1097668019818	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1097668019819	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1097668019820	active site
1097668019821	ATP binding site [chemical binding]; other site
1097668019822	substrate binding site [chemical binding]; other site
1097668019823	activation loop (A-loop); other site
1097668019824	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
1097668019825	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867
1097668019826	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
1097668019827	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1097668019828	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1097668019829	hypothetical protein; Provisional; Region: PRK07033
1097668019830	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
1097668019831	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668019832	ligand binding site [chemical binding]; other site
1097668019833	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
1097668019834	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
1097668019835	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1097668019836	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668019837	binding surface
1097668019838	TPR motif; other site
1097668019839	CHAT domain; Region: CHAT; pfam12770
1097668019840	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1097668019841	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1097668019842	Surface antigen; Region: Bac_surface_Ag; pfam01103
1097668019843	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1097668019844	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
1097668019845	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
1097668019846	Protein of unknown function (DUF770); Region: DUF770; pfam05591
1097668019847	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
1097668019848	Protein of unknown function (DUF877); Region: DUF877; pfam05943
1097668019849	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
1097668019850	active site
1097668019851	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1097668019852	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
1097668019853	phosphopeptide binding site; other site
1097668019854	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1097668019855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668019856	Walker A motif; other site
1097668019857	ATP binding site [chemical binding]; other site
1097668019858	Walker B motif; other site
1097668019859	arginine finger; other site
1097668019860	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668019861	Walker A motif; other site
1097668019862	ATP binding site [chemical binding]; other site
1097668019863	Walker B motif; other site
1097668019864	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1097668019865	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1097668019866	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1097668019867	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1097668019868	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1097668019869	Protein of unknown function (DUF796); Region: DUF796; cl01226
1097668019870	Protein of unknown function (DUF796); Region: DUF796; pfam05638
1097668019871	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1097668019872	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668019873	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668019874	Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715
1097668019875	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
1097668019876	3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147
1097668019877	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1097668019878	active site
1097668019879	Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937
1097668019880	conserved hypothetical protein; Region: TIGR02270
1097668019881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
1097668019882	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
1097668019883	Sterile alpha motif; Region: SAM; smart00454
1097668019884	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
1097668019885	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
1097668019886	cyclase homology domain; Region: CHD; cd07302
1097668019887	nucleotidyl binding site; other site
1097668019888	metal binding site [ion binding]; metal-binding site
1097668019889	dimer interface [polypeptide binding]; other site
1097668019890	AAA ATPase domain; Region: AAA_16; pfam13191
1097668019891	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
1097668019892	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
1097668019893	active site
1097668019894	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668019895	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1097668019896	active site
1097668019897	phosphorylation site [posttranslational modification]
1097668019898	intermolecular recognition site; other site
1097668019899	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668019900	DNA binding residues [nucleotide binding]
1097668019901	dimerization interface [polypeptide binding]; other site
1097668019902	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668019903	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668019904	ligand binding site [chemical binding]; other site
1097668019905	flexible hinge region; other site
1097668019906	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1097668019907	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1097668019908	active site
1097668019909	Zn binding site [ion binding]; other site
1097668019910	SAM domain (Sterile alpha motif); Region: SAM_2; pfam07647
1097668019911	SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487
1097668019912	cyclase homology domain; Region: CHD; cd07302
1097668019913	nucleotidyl binding site; other site
1097668019914	metal binding site [ion binding]; metal-binding site
1097668019915	dimer interface [polypeptide binding]; other site
1097668019916	AAA ATPase domain; Region: AAA_16; pfam13191
1097668019917	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1097668019918	dimanganese center [ion binding]; other site
1097668019919	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668019920	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1097668019921	putative active site [active]
1097668019922	heme pocket [chemical binding]; other site
1097668019923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668019924	putative active site [active]
1097668019925	heme pocket [chemical binding]; other site
1097668019926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668019927	dimer interface [polypeptide binding]; other site
1097668019928	phosphorylation site [posttranslational modification]
1097668019929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668019930	ATP binding site [chemical binding]; other site
1097668019931	Mg2+ binding site [ion binding]; other site
1097668019932	G-X-G motif; other site
1097668019933	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668019934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019935	active site
1097668019936	phosphorylation site [posttranslational modification]
1097668019937	intermolecular recognition site; other site
1097668019938	dimerization interface [polypeptide binding]; other site
1097668019939	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668019940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668019941	active site
1097668019942	phosphorylation site [posttranslational modification]
1097668019943	intermolecular recognition site; other site
1097668019944	dimerization interface [polypeptide binding]; other site
1097668019945	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1097668019946	LrgB-like family; Region: LrgB; pfam04172
1097668019947	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
1097668019948	putative glycosyl transferase; Provisional; Region: PRK10073
1097668019949	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097668019950	active site
1097668019951	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
1097668019952	active site
1097668019953	catalytic triad [active]
1097668019954	oxyanion hole [active]
1097668019955	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1097668019956	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1097668019957	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1097668019958	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
1097668019959	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668019960	acyl-activating enzyme (AAE) consensus motif; other site
1097668019961	AMP binding site [chemical binding]; other site
1097668019962	active site
1097668019963	CoA binding site [chemical binding]; other site
1097668019964	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668019965	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1097668019966	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1097668019967	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1097668019968	heme-binding site [chemical binding]; other site
1097668019969	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1097668019970	FAD binding pocket [chemical binding]; other site
1097668019971	FAD binding motif [chemical binding]; other site
1097668019972	phosphate binding motif [ion binding]; other site
1097668019973	beta-alpha-beta structure motif; other site
1097668019974	NAD binding pocket [chemical binding]; other site
1097668019975	Heme binding  pocket [chemical binding]; other site
1097668019976	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1097668019977	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668019978	substrate binding pocket [chemical binding]; other site
1097668019979	membrane-bound complex binding site; other site
1097668019980	hinge residues; other site
1097668019981	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1097668019982	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1097668019983	active site
1097668019984	dimer interface [polypeptide binding]; other site
1097668019985	non-prolyl cis peptide bond; other site
1097668019986	insertion regions; other site
1097668019987	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668019988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1097668019989	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668019990	putative PBP binding loops; other site
1097668019991	dimer interface [polypeptide binding]; other site
1097668019992	ABC-ATPase subunit interface; other site
1097668019993	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668019994	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668019995	Walker A/P-loop; other site
1097668019996	ATP binding site [chemical binding]; other site
1097668019997	Q-loop/lid; other site
1097668019998	ABC transporter signature motif; other site
1097668019999	Walker B; other site
1097668020000	D-loop; other site
1097668020001	H-loop/switch region; other site
1097668020002	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1097668020003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668020004	putative DNA binding site [nucleotide binding]; other site
1097668020005	putative Zn2+ binding site [ion binding]; other site
1097668020006	AsnC family; Region: AsnC_trans_reg; pfam01037
1097668020007	aromatic amino acid transporter; Provisional; Region: PRK10238
1097668020008	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1097668020009	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668020010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668020011	homodimer interface [polypeptide binding]; other site
1097668020012	catalytic residue [active]
1097668020013	acyl-CoA synthetase; Validated; Region: PRK06188
1097668020014	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668020015	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668020016	acyl-activating enzyme (AAE) consensus motif; other site
1097668020017	AMP binding site [chemical binding]; other site
1097668020018	active site
1097668020019	CoA binding site [chemical binding]; other site
1097668020020	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066
1097668020021	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1097668020022	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1097668020023	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1097668020024	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020025	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668020026	putative substrate translocation pore; other site
1097668020027	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1097668020028	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1097668020029	ligand binding site [chemical binding]; other site
1097668020030	flexible hinge region; other site
1097668020031	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1097668020032	non-specific DNA interactions [nucleotide binding]; other site
1097668020033	DNA binding site [nucleotide binding]
1097668020034	sequence specific DNA binding site [nucleotide binding]; other site
1097668020035	putative cAMP binding site [chemical binding]; other site
1097668020036	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1097668020037	active site
1097668020038	short chain dehydrogenase; Provisional; Region: PRK12829
1097668020039	classical (c) SDRs; Region: SDR_c; cd05233
1097668020040	NAD(P) binding site [chemical binding]; other site
1097668020041	active site
1097668020042	Benzoate membrane transport protein; Region: BenE; pfam03594
1097668020043	benzoate transporter; Region: benE; TIGR00843
1097668020044	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
1097668020045	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
1097668020046	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
1097668020047	octamer interface [polypeptide binding]; other site
1097668020048	active site
1097668020049	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1097668020050	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020051	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
1097668020052	dimerizarion interface [polypeptide binding]; other site
1097668020053	CrgA pocket; other site
1097668020054	substrate binding pocket [chemical binding]; other site
1097668020055	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
1097668020056	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
1097668020057	dimer interface [polypeptide binding]; other site
1097668020058	active site
1097668020059	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
1097668020060	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
1097668020061	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
1097668020062	putative alpha subunit interface [polypeptide binding]; other site
1097668020063	putative active site [active]
1097668020064	putative substrate binding site [chemical binding]; other site
1097668020065	Fe binding site [ion binding]; other site
1097668020066	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1097668020067	inter-subunit interface; other site
1097668020068	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
1097668020069	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668020070	catalytic loop [active]
1097668020071	iron binding site [ion binding]; other site
1097668020072	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
1097668020073	FAD binding pocket [chemical binding]; other site
1097668020074	FAD binding motif [chemical binding]; other site
1097668020075	phosphate binding motif [ion binding]; other site
1097668020076	beta-alpha-beta structure motif; other site
1097668020077	NAD binding pocket [chemical binding]; other site
1097668020078	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
1097668020079	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668020080	NAD(P) binding site [chemical binding]; other site
1097668020081	active site
1097668020082	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
1097668020083	homotrimer interaction site [polypeptide binding]; other site
1097668020084	putative active site [active]
1097668020085	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1097668020086	G1 box; other site
1097668020087	GTP/Mg2+ binding site [chemical binding]; other site
1097668020088	G2 box; other site
1097668020089	Switch I region; other site
1097668020090	G3 box; other site
1097668020091	Switch II region; other site
1097668020092	G4 box; other site
1097668020093	G5 box; other site
1097668020094	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1097668020095	G1 box; other site
1097668020096	GTP/Mg2+ binding site [chemical binding]; other site
1097668020097	G2 box; other site
1097668020098	G3 box; other site
1097668020099	Switch II region; other site
1097668020100	G4 box; other site
1097668020101	G5 box; other site
1097668020102	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668020103	NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152
1097668020104	NAD(P) binding site [chemical binding]; other site
1097668020105	catalytic residues [active]
1097668020106	benzoate transport; Region: 2A0115; TIGR00895
1097668020107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020108	putative substrate translocation pore; other site
1097668020109	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020110	putative substrate translocation pore; other site
1097668020111	Mandelate racemase (MR) catalyzes the Mg2+-dependent 1,1-proton transfer reaction that interconverts the enantiomers of mandelic acid. MR is the first enzyme in the bacterial pathway that converts mandelic acid to benzoic acid and allows this pathway to...; Region: mandelate_racemase; cd03321
1097668020112	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668020113	active site
1097668020114	glycolate oxidase; Region: PLN02535
1097668020115	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1097668020116	phosphate binding site [ion binding]; other site
1097668020117	benzoylformate decarboxylase; Reviewed; Region: PRK07092
1097668020118	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1097668020119	PYR/PP interface [polypeptide binding]; other site
1097668020120	dimer interface [polypeptide binding]; other site
1097668020121	TPP binding site [chemical binding]; other site
1097668020122	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668020123	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
1097668020124	TPP-binding site [chemical binding]; other site
1097668020125	dimer interface [polypeptide binding]; other site
1097668020126	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020127	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020128	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668020129	substrate binding pocket [chemical binding]; other site
1097668020130	dimerization interface [polypeptide binding]; other site
1097668020131	benzoate transport; Region: 2A0115; TIGR00895
1097668020132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020133	putative substrate translocation pore; other site
1097668020134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020135	putative substrate translocation pore; other site
1097668020136	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1097668020137	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1097668020138	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
1097668020139	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020140	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668020141	putative substrate translocation pore; other site
1097668020142	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1097668020143	short chain dehydrogenase; Provisional; Region: PRK12829
1097668020144	classical (c) SDRs; Region: SDR_c; cd05233
1097668020145	NAD(P) binding site [chemical binding]; other site
1097668020146	active site
1097668020147	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668020148	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668020149	DNA-binding site [nucleotide binding]; DNA binding site
1097668020150	FCD domain; Region: FCD; pfam07729
1097668020151	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1097668020152	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1097668020153	Walker A/P-loop; other site
1097668020154	ATP binding site [chemical binding]; other site
1097668020155	Q-loop/lid; other site
1097668020156	ABC transporter signature motif; other site
1097668020157	Walker B; other site
1097668020158	D-loop; other site
1097668020159	H-loop/switch region; other site
1097668020160	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1097668020161	FtsX-like permease family; Region: FtsX; pfam02687
1097668020162	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1097668020163	FtsX-like permease family; Region: FtsX; pfam02687
1097668020164	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
1097668020165	putative peptidase; Provisional; Region: PRK11649
1097668020166	Peptidase family M23; Region: Peptidase_M23; pfam01551
1097668020167	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668020168	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668020169	metal binding site [ion binding]; metal-binding site
1097668020170	active site
1097668020171	I-site; other site
1097668020172	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
1097668020173	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668020174	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1097668020175	MbtH-like protein; Region: MbtH; cl01279
1097668020176	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1097668020177	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1097668020178	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668020179	Walker A/P-loop; other site
1097668020180	ATP binding site [chemical binding]; other site
1097668020181	Q-loop/lid; other site
1097668020182	ABC transporter signature motif; other site
1097668020183	Walker B; other site
1097668020184	D-loop; other site
1097668020185	H-loop/switch region; other site
1097668020186	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1097668020187	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097668020188	ABC-ATPase subunit  interface; other site
1097668020189	dimer interface [polypeptide binding]; other site
1097668020190	putative PBP binding regions; other site
1097668020191	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1097668020192	ABC-ATPase subunit  interface; other site
1097668020193	dimer interface [polypeptide binding]; other site
1097668020194	putative PBP binding regions; other site
1097668020195	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
1097668020196	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1097668020197	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1097668020198	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1097668020199	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1097668020200	siderophore binding site; other site
1097668020201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020202	putative substrate translocation pore; other site
1097668020203	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668020204	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
1097668020205	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1097668020206	classical (c) SDRs; Region: SDR_c; cd05233
1097668020207	NAD(P) binding site [chemical binding]; other site
1097668020208	active site
1097668020209	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668020210	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668020211	conserved cys residue [active]
1097668020212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668020213	allantoate amidohydrolase; Reviewed; Region: PRK12893
1097668020214	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668020215	active site
1097668020216	metal binding site [ion binding]; metal-binding site
1097668020217	dimer interface [polypeptide binding]; other site
1097668020218	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1097668020219	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668020220	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1097668020221	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1097668020222	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1097668020223	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1097668020224	NADP binding site [chemical binding]; other site
1097668020225	dimer interface [polypeptide binding]; other site
1097668020226	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1097668020227	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1097668020228	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668020229	DNA binding residues [nucleotide binding]
1097668020230	dimerization interface [polypeptide binding]; other site
1097668020231	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
1097668020232	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1097668020233	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1097668020234	active site
1097668020235	catalytic site [active]
1097668020236	Predicted permease [General function prediction only]; Region: COG2985
1097668020237	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1097668020238	TrkA-C domain; Region: TrkA_C; pfam02080
1097668020239	TrkA-C domain; Region: TrkA_C; pfam02080
1097668020240	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
1097668020241	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1097668020242	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1097668020243	putative ligand binding site [chemical binding]; other site
1097668020244	putative NAD binding site [chemical binding]; other site
1097668020245	catalytic site [active]
1097668020246	CCC1-related family of proteins; Region: CCC1_like; cl00278
1097668020247	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
1097668020248	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1097668020249	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1097668020250	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1097668020251	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1097668020252	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1097668020253	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
1097668020254	phosphate acetyltransferase; Provisional; Region: PRK11890
1097668020255	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
1097668020256	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
1097668020257	propionate/acetate kinase; Provisional; Region: PRK12379
1097668020258	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
1097668020259	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1097668020260	NAD binding site [chemical binding]; other site
1097668020261	homotetramer interface [polypeptide binding]; other site
1097668020262	homodimer interface [polypeptide binding]; other site
1097668020263	substrate binding site [chemical binding]; other site
1097668020264	active site
1097668020265	Protein of unknown function (DUF796); Region: DUF796; cl01226
1097668020266	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1097668020267	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1097668020268	mce related protein; Region: MCE; pfam02470
1097668020269	mce related protein; Region: MCE; pfam02470
1097668020270	mce related protein; Region: MCE; pfam02470
1097668020271	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
1097668020272	Paraquat-inducible protein A; Region: PqiA; pfam04403
1097668020273	Paraquat-inducible protein A; Region: PqiA; pfam04403
1097668020274	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668020275	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1097668020276	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668020277	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668020278	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668020279	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668020280	DNA-binding site [nucleotide binding]; DNA binding site
1097668020281	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668020282	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668020283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668020284	homodimer interface [polypeptide binding]; other site
1097668020285	catalytic residue [active]
1097668020286	gamma-aminobutyrate permease; Region: GABAperm; TIGR01773
1097668020287	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1097668020288	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1097668020289	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668020290	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1097668020291	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1097668020292	dimerization interface [polypeptide binding]; other site
1097668020293	ligand binding site [chemical binding]; other site
1097668020294	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1097668020295	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1097668020296	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1097668020297	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1097668020298	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1097668020299	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1097668020300	Na binding site [ion binding]; other site
1097668020301	succinic semialdehyde dehydrogenase; Region: PLN02278
1097668020302	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668020303	tetramerization interface [polypeptide binding]; other site
1097668020304	NAD(P) binding site [chemical binding]; other site
1097668020305	catalytic residues [active]
1097668020306	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668020307	Ligand Binding Site [chemical binding]; other site
1097668020308	alpha-glucosidase; Provisional; Region: PRK10137
1097668020309	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
1097668020310	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
1097668020311	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1097668020312	RNA polymerase sigma factor; Provisional; Region: PRK11922
1097668020313	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668020314	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668020315	DNA binding residues [nucleotide binding]
1097668020316	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668020317	NmrA-like family; Region: NmrA; pfam05368
1097668020318	NAD(P) binding site [chemical binding]; other site
1097668020319	active site
1097668020320	MEKHLA domain; Region: MEKHLA; pfam08670
1097668020321	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668020322	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668020323	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668020324	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668020325	hypothetical protein; Validated; Region: PRK06201
1097668020326	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
1097668020327	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1097668020328	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1097668020329	ligand binding site [chemical binding]; other site
1097668020330	NAD binding site [chemical binding]; other site
1097668020331	dimerization interface [polypeptide binding]; other site
1097668020332	catalytic site [active]
1097668020333	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097668020334	Strictosidine synthase; Region: Str_synth; pfam03088
1097668020335	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668020336	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020337	putative substrate translocation pore; other site
1097668020338	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668020339	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668020340	trimer interface [polypeptide binding]; other site
1097668020341	eyelet of channel; other site
1097668020342	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097668020343	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668020344	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020345	putative substrate translocation pore; other site
1097668020346	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668020347	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1097668020348	putative NAD(P) binding site [chemical binding]; other site
1097668020349	putative active site [active]
1097668020350	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
1097668020351	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097668020352	putative NAD(P) binding site [chemical binding]; other site
1097668020353	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668020354	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
1097668020355	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1097668020356	CGNR zinc finger; Region: zf-CGNR; pfam11706
1097668020357	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1097668020358	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1097668020359	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668020360	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668020361	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1097668020362	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668020363	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668020364	DNA-binding site [nucleotide binding]; DNA binding site
1097668020365	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668020366	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1097668020367	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668020368	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1097668020369	alpha subunit interface [polypeptide binding]; other site
1097668020370	active site
1097668020371	substrate binding site [chemical binding]; other site
1097668020372	Fe binding site [ion binding]; other site
1097668020373	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1097668020374	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1097668020375	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1097668020376	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668020377	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668020378	catalytic loop [active]
1097668020379	iron binding site [ion binding]; other site
1097668020380	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1097668020381	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668020382	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668020383	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1097668020384	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1097668020385	catalytic triad [active]
1097668020386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020387	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020388	The C-terminal substrate binding domain of LysR-type transcriptional regulator PnbR, which is involved in regulating the pnb genes encoding enzymes for 4-nitrobenzoate catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_PnbR; cd08469
1097668020389	putative substrate binding pocket [chemical binding]; other site
1097668020390	putative dimerization interface [polypeptide binding]; other site
1097668020391	benzoate transport; Region: 2A0115; TIGR00895
1097668020392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020393	putative substrate translocation pore; other site
1097668020394	Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109
1097668020395	ProQ/FINO family; Region: ProQ; pfam04352
1097668020396	putative RNA binding sites [nucleotide binding]; other site
1097668020397	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668020398	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668020399	trimer interface [polypeptide binding]; other site
1097668020400	eyelet of channel; other site
1097668020401	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1097668020402	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668020403	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668020404	trimer interface [polypeptide binding]; other site
1097668020405	eyelet of channel; other site
1097668020406	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668020407	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1097668020408	conserved cys residue [active]
1097668020409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668020410	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
1097668020411	enoyl-CoA hydratase; Provisional; Region: PRK09245
1097668020412	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668020413	substrate binding site [chemical binding]; other site
1097668020414	oxyanion hole (OAH) forming residues; other site
1097668020415	trimer interface [polypeptide binding]; other site
1097668020416	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1097668020417	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668020418	acyl-activating enzyme (AAE) consensus motif; other site
1097668020419	AMP binding site [chemical binding]; other site
1097668020420	active site
1097668020421	CoA binding site [chemical binding]; other site
1097668020422	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668020423	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1097668020424	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1097668020425	active site
1097668020426	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1097668020427	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
1097668020428	putative active site [active]
1097668020429	catalytic triad [active]
1097668020430	putative dimer interface [polypeptide binding]; other site
1097668020431	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1097668020432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668020433	dimer interface [polypeptide binding]; other site
1097668020434	conserved gate region; other site
1097668020435	putative PBP binding loops; other site
1097668020436	ABC-ATPase subunit interface; other site
1097668020437	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1097668020438	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1097668020439	Walker A/P-loop; other site
1097668020440	ATP binding site [chemical binding]; other site
1097668020441	Q-loop/lid; other site
1097668020442	ABC transporter signature motif; other site
1097668020443	Walker B; other site
1097668020444	D-loop; other site
1097668020445	H-loop/switch region; other site
1097668020446	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1097668020447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668020448	dimer interface [polypeptide binding]; other site
1097668020449	conserved gate region; other site
1097668020450	ABC-ATPase subunit interface; other site
1097668020451	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1097668020452	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668020453	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668020454	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1097668020455	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1097668020456	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1097668020457	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1097668020458	TIGR02594 family protein; Region: TIGR02594
1097668020459	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1097668020460	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668020461	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1097668020462	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1097668020463	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
1097668020464	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
1097668020465	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668020466	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668020467	putative active site [active]
1097668020468	catalytic site [active]
1097668020469	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668020470	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668020471	putative active site [active]
1097668020472	catalytic site [active]
1097668020473	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1097668020474	Sel1-like repeats; Region: SEL1; smart00671
1097668020475	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1097668020476	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1097668020477	Sel1-like repeats; Region: SEL1; smart00671
1097668020478	PAAR motif; Region: PAAR_motif; pfam05488
1097668020479	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
1097668020480	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
1097668020481	Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947
1097668020482	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
1097668020483	Protein of unknown function (DUF1305); Region: DUF1305; pfam06996
1097668020484	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
1097668020485	acetoacetate decarboxylase; Provisional; Region: PRK02265
1097668020486	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1097668020487	classical (c) SDRs; Region: SDR_c; cd05233
1097668020488	NAD(P) binding site [chemical binding]; other site
1097668020489	active site
1097668020490	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1097668020491	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1097668020492	active site
1097668020493	nucleophile elbow; other site
1097668020494	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1097668020495	Patatin phospholipase; Region: DUF3734; pfam12536
1097668020496	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1097668020497	putative dimer interface [polypeptide binding]; other site
1097668020498	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668020499	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020500	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020501	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020502	dimerization interface [polypeptide binding]; other site
1097668020503	hypothetical protein; Provisional; Region: PRK07079
1097668020504	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
1097668020505	metal binding site [ion binding]; metal-binding site
1097668020506	putative dimer interface [polypeptide binding]; other site
1097668020507	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668020508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020509	putative substrate translocation pore; other site
1097668020510	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
1097668020511	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1097668020512	non-specific DNA binding site [nucleotide binding]; other site
1097668020513	salt bridge; other site
1097668020514	sequence-specific DNA binding site [nucleotide binding]; other site
1097668020515	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668020516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020517	putative substrate translocation pore; other site
1097668020518	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
1097668020519	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
1097668020520	dimer interface [polypeptide binding]; other site
1097668020521	active site
1097668020522	catalytic residue [active]
1097668020523	metal binding site [ion binding]; metal-binding site
1097668020524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1097668020525	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668020526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020527	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020528	dimerization interface [polypeptide binding]; other site
1097668020529	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668020530	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1097668020531	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668020532	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1097668020533	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1097668020534	FMN binding site [chemical binding]; other site
1097668020535	substrate binding site [chemical binding]; other site
1097668020536	putative catalytic residue [active]
1097668020537	NYN domain; Region: NYN; pfam01936
1097668020538	putative metal binding site [ion binding]; other site
1097668020539	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1097668020540	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
1097668020541	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1097668020542	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668020543	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1097668020544	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668020545	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668020546	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668020547	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668020548	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1097668020549	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1097668020550	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1097668020551	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1097668020552	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1097668020553	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1097668020554	putative molybdopterin cofactor binding site [chemical binding]; other site
1097668020555	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1097668020556	putative molybdopterin cofactor binding site; other site
1097668020557	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668020558	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668020559	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1097668020560	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668020561	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668020562	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1097668020563	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668020564	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
1097668020565	putative hydrophobic ligand binding site [chemical binding]; other site
1097668020566	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1097668020567	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
1097668020568	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668020569	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668020570	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1097668020571	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1097668020572	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668020573	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668020574	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1097668020575	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1097668020576	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668020577	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020578	The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_beta_lactamase; cd08484
1097668020579	putative dimerization interface [polypeptide binding]; other site
1097668020580	putative substrate binding pocket [chemical binding]; other site
1097668020581	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
1097668020582	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097668020583	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020584	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020585	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668020586	putative dimerization interface [polypeptide binding]; other site
1097668020587	3-isopropylmalate dehydratase, small subunit; Region: LEUD_arch; TIGR02087
1097668020588	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
1097668020589	substrate binding site [chemical binding]; other site
1097668020590	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1097668020591	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1097668020592	substrate binding site [chemical binding]; other site
1097668020593	ligand binding site [chemical binding]; other site
1097668020594	benzoate transport; Region: 2A0115; TIGR00895
1097668020595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020596	putative substrate translocation pore; other site
1097668020597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020600	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1097668020601	putative substrate binding pocket [chemical binding]; other site
1097668020602	dimerization interface [polypeptide binding]; other site
1097668020603	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
1097668020604	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1097668020605	dimer interface [polypeptide binding]; other site
1097668020606	PYR/PP interface [polypeptide binding]; other site
1097668020607	TPP binding site [chemical binding]; other site
1097668020608	substrate binding site [chemical binding]; other site
1097668020609	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
1097668020610	TPP-binding site; other site
1097668020611	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1097668020612	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1097668020613	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020614	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020615	dimerization interface [polypeptide binding]; other site
1097668020616	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1097668020617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020618	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668020619	putative substrate translocation pore; other site
1097668020620	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668020621	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668020622	inhibitor site; inhibition site
1097668020623	active site
1097668020624	dimer interface [polypeptide binding]; other site
1097668020625	catalytic residue [active]
1097668020626	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668020627	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668020628	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1097668020629	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1097668020630	ligand binding site [chemical binding]; other site
1097668020631	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1097668020632	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668020633	Walker A/P-loop; other site
1097668020634	ATP binding site [chemical binding]; other site
1097668020635	Q-loop/lid; other site
1097668020636	ABC transporter signature motif; other site
1097668020637	Walker B; other site
1097668020638	D-loop; other site
1097668020639	H-loop/switch region; other site
1097668020640	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668020641	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668020642	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668020643	TM-ABC transporter signature motif; other site
1097668020644	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1097668020645	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
1097668020646	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
1097668020647	dimer interface [polypeptide binding]; other site
1097668020648	motif 1; other site
1097668020649	active site
1097668020650	motif 2; other site
1097668020651	motif 3; other site
1097668020652	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668020653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668020654	active site
1097668020655	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668020656	active site
1097668020657	acyl carrier protein; Provisional; Region: PRK07081
1097668020658	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1097668020659	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1097668020660	putative active site [active]
1097668020661	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1097668020662	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097668020663	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1097668020664	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1097668020665	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668020666	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668020667	DNA-binding site [nucleotide binding]; DNA binding site
1097668020668	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668020669	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668020670	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1097668020671	putative ADP-binding pocket [chemical binding]; other site
1097668020672	Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969
1097668020673	putative active site [active]
1097668020674	putative metal binding site [ion binding]; other site
1097668020675	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668020676	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1097668020677	active site clefts [active]
1097668020678	zinc binding site [ion binding]; other site
1097668020679	dimer interface [polypeptide binding]; other site
1097668020680	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1097668020681	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1097668020682	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1097668020683	RNA polymerase sigma factor; Provisional; Region: PRK12547
1097668020684	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668020685	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668020686	DNA binding residues [nucleotide binding]
1097668020687	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020688	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020689	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1097668020690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020691	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
1097668020692	putative dimerization interface [polypeptide binding]; other site
1097668020693	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668020694	Ligand Binding Site [chemical binding]; other site
1097668020695	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668020696	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668020697	DNA-binding site [nucleotide binding]; DNA binding site
1097668020698	FCD domain; Region: FCD; pfam07729
1097668020699	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668020700	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668020701	DNA-binding site [nucleotide binding]; DNA binding site
1097668020702	FCD domain; Region: FCD; pfam07729
1097668020703	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1097668020704	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1097668020705	membrane-bound complex binding site; other site
1097668020706	hinge residues; other site
1097668020707	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668020708	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668020709	Walker A/P-loop; other site
1097668020710	ATP binding site [chemical binding]; other site
1097668020711	Q-loop/lid; other site
1097668020712	ABC transporter signature motif; other site
1097668020713	Walker B; other site
1097668020714	D-loop; other site
1097668020715	H-loop/switch region; other site
1097668020716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668020717	dimer interface [polypeptide binding]; other site
1097668020718	conserved gate region; other site
1097668020719	putative PBP binding loops; other site
1097668020720	ABC-ATPase subunit interface; other site
1097668020721	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668020722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668020723	dimer interface [polypeptide binding]; other site
1097668020724	conserved gate region; other site
1097668020725	putative PBP binding loops; other site
1097668020726	ABC-ATPase subunit interface; other site
1097668020727	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1097668020728	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1097668020729	substrate binding site [chemical binding]; other site
1097668020730	ligand binding site [chemical binding]; other site
1097668020731	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1097668020732	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1097668020733	substrate binding site [chemical binding]; other site
1097668020734	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668020735	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668020736	tetramer interface [polypeptide binding]; other site
1097668020737	active site
1097668020738	Mg2+/Mn2+ binding site [ion binding]; other site
1097668020739	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1097668020740	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1097668020741	FAD binding pocket [chemical binding]; other site
1097668020742	FAD binding motif [chemical binding]; other site
1097668020743	phosphate binding motif [ion binding]; other site
1097668020744	NAD binding pocket [chemical binding]; other site
1097668020745	Predicted transcriptional regulators [Transcription]; Region: COG1695
1097668020746	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1097668020747	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1097668020748	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1097668020749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668020750	S-adenosylmethionine binding site [chemical binding]; other site
1097668020751	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
1097668020752	putative active site 1 [active]
1097668020753	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
1097668020754	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
1097668020755	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1097668020756	dimer interface [polypeptide binding]; other site
1097668020757	active site
1097668020758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668020759	S-adenosylmethionine binding site [chemical binding]; other site
1097668020760	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1097668020761	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1097668020762	NodB motif; other site
1097668020763	active site
1097668020764	catalytic site [active]
1097668020765	metal binding site [ion binding]; metal-binding site
1097668020766	Predicted exporter [General function prediction only]; Region: COG4258
1097668020767	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1097668020768	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1097668020769	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1097668020770	putative acyl-acceptor binding pocket; other site
1097668020771	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1097668020772	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668020773	acyl-activating enzyme (AAE) consensus motif; other site
1097668020774	AMP binding site [chemical binding]; other site
1097668020775	active site
1097668020776	CoA binding site [chemical binding]; other site
1097668020777	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
1097668020778	active site 2 [active]
1097668020779	dimer interface [polypeptide binding]; other site
1097668020780	active site 1 [active]
1097668020781	Predicted membrane protein [Function unknown]; Region: COG4648
1097668020782	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1097668020783	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668020784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668020785	NAD(P) binding site [chemical binding]; other site
1097668020786	active site
1097668020787	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668020788	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1097668020789	MltA-interacting protein MipA; Region: MipA; cl01504
1097668020790	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1097668020791	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1097668020792	putative acyl-acceptor binding pocket; other site
1097668020793	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1097668020794	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1097668020795	Ligand binding site; other site
1097668020796	Putative Catalytic site; other site
1097668020797	DXD motif; other site
1097668020798	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668020799	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668020800	dimerization interface [polypeptide binding]; other site
1097668020801	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1097668020802	dimer interface [polypeptide binding]; other site
1097668020803	phosphorylation site [posttranslational modification]
1097668020804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668020805	ATP binding site [chemical binding]; other site
1097668020806	Mg2+ binding site [ion binding]; other site
1097668020807	G-X-G motif; other site
1097668020808	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668020809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668020810	active site
1097668020811	phosphorylation site [posttranslational modification]
1097668020812	intermolecular recognition site; other site
1097668020813	dimerization interface [polypeptide binding]; other site
1097668020814	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668020815	DNA binding site [nucleotide binding]
1097668020816	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1097668020817	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668020818	catalytic residues [active]
1097668020819	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1097668020820	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020821	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020822	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1097668020823	putative effector binding pocket; other site
1097668020824	putative dimerization interface [polypeptide binding]; other site
1097668020825	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1097668020826	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1097668020827	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668020828	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020829	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668020830	dimerization interface [polypeptide binding]; other site
1097668020831	substrate binding pocket [chemical binding]; other site
1097668020832	sugar efflux transporter; Region: 2A0120; TIGR00899
1097668020833	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020834	chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348
1097668020835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020836	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020837	dimerization interface [polypeptide binding]; other site
1097668020838	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097668020839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020840	putative substrate translocation pore; other site
1097668020841	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1097668020842	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1097668020843	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
1097668020844	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
1097668020845	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1097668020846	hinge; other site
1097668020847	active site
1097668020848	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1097668020849	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1097668020850	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668020851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668020852	homodimer interface [polypeptide binding]; other site
1097668020853	catalytic residue [active]
1097668020854	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1097668020855	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1097668020856	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1097668020857	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668020858	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668020859	catalytic loop [active]
1097668020860	iron binding site [ion binding]; other site
1097668020861	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
1097668020862	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668020863	Beta-lactamase; Region: Beta-lactamase; pfam00144
1097668020864	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1097668020865	Predicted membrane protein [Function unknown]; Region: COG2860
1097668020866	UPF0126 domain; Region: UPF0126; pfam03458
1097668020867	UPF0126 domain; Region: UPF0126; pfam03458
1097668020868	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1097668020869	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1097668020870	metal binding site [ion binding]; metal-binding site
1097668020871	putative dimer interface [polypeptide binding]; other site
1097668020872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020873	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668020874	putative substrate translocation pore; other site
1097668020875	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
1097668020876	Predicted acyl esterases [General function prediction only]; Region: COG2936
1097668020877	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
1097668020878	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1097668020879	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1097668020880	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668020881	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1097668020882	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668020883	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668020884	active site
1097668020885	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668020886	active site
1097668020887	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1097668020888	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097668020889	Cytochrome P450; Region: p450; cl12078
1097668020890	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668020891	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668020892	maltose O-acetyltransferase; Provisional; Region: PRK10092
1097668020893	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1097668020894	active site
1097668020895	substrate binding site [chemical binding]; other site
1097668020896	trimer interface [polypeptide binding]; other site
1097668020897	CoA binding site [chemical binding]; other site
1097668020898	Predicted methyltransferase [General function prediction only]; Region: COG4798
1097668020899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020900	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
1097668020901	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020902	dimerization interface [polypeptide binding]; other site
1097668020903	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668020904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668020905	NAD(P) binding site [chemical binding]; other site
1097668020906	active site
1097668020907	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1097668020908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020909	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668020910	putative substrate translocation pore; other site
1097668020911	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020912	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668020913	putative substrate translocation pore; other site
1097668020914	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1097668020915	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668020916	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020917	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
1097668020918	substrate binding pocket [chemical binding]; other site
1097668020919	dimerization interface [polypeptide binding]; other site
1097668020920	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668020921	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668020922	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668020923	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668020924	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668020925	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668020926	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668020927	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668020928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020929	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020930	dimerization interface [polypeptide binding]; other site
1097668020931	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1097668020932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020933	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020934	dimerization interface [polypeptide binding]; other site
1097668020935	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1097668020936	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1097668020937	active site
1097668020938	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1097668020939	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
1097668020940	Flavoprotein; Region: Flavoprotein; pfam02441
1097668020941	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1097668020942	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1097668020943	P-loop, Walker A motif; other site
1097668020944	Base recognition motif; other site
1097668020945	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1097668020946	xanthine permease; Region: pbuX; TIGR03173
1097668020947	amidohydrolase; Provisional; Region: PRK12393
1097668020948	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1097668020949	active site
1097668020950	putative substrate binding pocket [chemical binding]; other site
1097668020951	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1097668020952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020953	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668020954	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668020955	dimerization interface [polypeptide binding]; other site
1097668020956	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1097668020957	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668020958	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1097668020959	active site
1097668020960	benzoate transport; Region: 2A0115; TIGR00895
1097668020961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020962	putative substrate translocation pore; other site
1097668020963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020964	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
1097668020965	GAF domain; Region: GAF_2; pfam13185
1097668020966	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668020967	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668020968	trimer interface [polypeptide binding]; other site
1097668020969	eyelet of channel; other site
1097668020970	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1097668020971	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020972	putative substrate translocation pore; other site
1097668020973	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
1097668020974	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1097668020975	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668020976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668020977	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668020978	dimerization interface [polypeptide binding]; other site
1097668020979	substrate binding pocket [chemical binding]; other site
1097668020980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668020981	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668020982	putative substrate translocation pore; other site
1097668020983	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1097668020984	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1097668020985	active site
1097668020986	dimer interface [polypeptide binding]; other site
1097668020987	PAS domain; Region: PAS_9; pfam13426
1097668020988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1097668020989	putative active site [active]
1097668020990	heme pocket [chemical binding]; other site
1097668020991	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668020992	DNA binding residues [nucleotide binding]
1097668020993	dimerization interface [polypeptide binding]; other site
1097668020994	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1097668020995	Amidase; Region: Amidase; cl11426
1097668020996	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668020997	classical (c) SDRs; Region: SDR_c; cd05233
1097668020998	NAD(P) binding site [chemical binding]; other site
1097668020999	active site
1097668021000	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1097668021001	ANTAR domain; Region: ANTAR; pfam03861
1097668021002	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668021003	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
1097668021004	ligand binding site [chemical binding]; other site
1097668021005	regulator interaction site; other site
1097668021006	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
1097668021007	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668021008	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668021009	Walker A/P-loop; other site
1097668021010	ATP binding site [chemical binding]; other site
1097668021011	Q-loop/lid; other site
1097668021012	ABC transporter signature motif; other site
1097668021013	Walker B; other site
1097668021014	D-loop; other site
1097668021015	H-loop/switch region; other site
1097668021016	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1097668021017	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668021018	Walker A/P-loop; other site
1097668021019	ATP binding site [chemical binding]; other site
1097668021020	Q-loop/lid; other site
1097668021021	ABC transporter signature motif; other site
1097668021022	Walker B; other site
1097668021023	D-loop; other site
1097668021024	H-loop/switch region; other site
1097668021025	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668021026	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668021027	TM-ABC transporter signature motif; other site
1097668021028	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668021029	TM-ABC transporter signature motif; other site
1097668021030	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668021031	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356
1097668021032	putative ligand binding site [chemical binding]; other site
1097668021033	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1097668021034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668021035	motif II; other site
1097668021036	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1097668021037	intersubunit interface [polypeptide binding]; other site
1097668021038	active site
1097668021039	Zn2+ binding site [ion binding]; other site
1097668021040	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021041	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668021042	putative substrate translocation pore; other site
1097668021043	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668021044	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021045	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668021046	putative effector binding pocket; other site
1097668021047	dimerization interface [polypeptide binding]; other site
1097668021048	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668021049	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668021050	Walker A/P-loop; other site
1097668021051	ATP binding site [chemical binding]; other site
1097668021052	Q-loop/lid; other site
1097668021053	ABC transporter signature motif; other site
1097668021054	Walker B; other site
1097668021055	D-loop; other site
1097668021056	H-loop/switch region; other site
1097668021057	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668021058	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668021059	Walker A/P-loop; other site
1097668021060	ATP binding site [chemical binding]; other site
1097668021061	Q-loop/lid; other site
1097668021062	ABC transporter signature motif; other site
1097668021063	Walker B; other site
1097668021064	D-loop; other site
1097668021065	H-loop/switch region; other site
1097668021066	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668021067	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668021068	TM-ABC transporter signature motif; other site
1097668021069	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668021070	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668021071	TM-ABC transporter signature motif; other site
1097668021072	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668021073	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336
1097668021074	putative ligand binding site [chemical binding]; other site
1097668021075	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668021076	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668021077	trimer interface [polypeptide binding]; other site
1097668021078	eyelet of channel; other site
1097668021079	SnoaL-like domain; Region: SnoaL_4; pfam13577
1097668021080	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1097668021081	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1097668021082	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668021083	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668021084	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1097668021085	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1097668021086	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668021087	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668021088	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668021089	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668021090	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1097668021091	non-specific DNA interactions [nucleotide binding]; other site
1097668021092	DNA binding site [nucleotide binding]
1097668021093	sequence specific DNA binding site [nucleotide binding]; other site
1097668021094	putative cAMP binding site [chemical binding]; other site
1097668021095	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1097668021096	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668021097	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
1097668021098	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
1097668021099	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1097668021100	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1097668021101	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668021102	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668021103	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668021104	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1097668021105	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1097668021106	phosphate binding site [ion binding]; other site
1097668021107	short chain dehydrogenase; Provisional; Region: PRK06125
1097668021108	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021109	NAD(P) binding site [chemical binding]; other site
1097668021110	active site
1097668021111	EthD domain; Region: EthD; cl17553
1097668021112	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668021113	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668021114	TM-ABC transporter signature motif; other site
1097668021115	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668021116	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668021117	TM-ABC transporter signature motif; other site
1097668021118	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668021119	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668021120	Walker A/P-loop; other site
1097668021121	ATP binding site [chemical binding]; other site
1097668021122	Q-loop/lid; other site
1097668021123	ABC transporter signature motif; other site
1097668021124	Walker B; other site
1097668021125	D-loop; other site
1097668021126	H-loop/switch region; other site
1097668021127	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668021128	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668021129	Walker A/P-loop; other site
1097668021130	ATP binding site [chemical binding]; other site
1097668021131	Q-loop/lid; other site
1097668021132	ABC transporter signature motif; other site
1097668021133	Walker B; other site
1097668021134	D-loop; other site
1097668021135	H-loop/switch region; other site
1097668021136	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668021137	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1097668021138	putative ligand binding site [chemical binding]; other site
1097668021139	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668021140	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021141	NAD(P) binding site [chemical binding]; other site
1097668021142	active site
1097668021143	classical (c) SDRs; Region: SDR_c; cd05233
1097668021144	active site
1097668021145	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1097668021146	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668021147	active site
1097668021148	NAD binding site [chemical binding]; other site
1097668021149	metal binding site [ion binding]; metal-binding site
1097668021150	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
1097668021151	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1097668021152	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
1097668021153	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668021154	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668021155	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668021156	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668021157	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1097668021158	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668021159	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668021160	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668021161	active site
1097668021162	enoyl-CoA hydratase; Region: PLN02864
1097668021163	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668021164	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
1097668021165	dimer interaction site [polypeptide binding]; other site
1097668021166	substrate-binding tunnel; other site
1097668021167	active site
1097668021168	catalytic site [active]
1097668021169	substrate binding site [chemical binding]; other site
1097668021170	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668021171	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021172	NAD(P) binding site [chemical binding]; other site
1097668021173	active site
1097668021174	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
1097668021175	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668021176	dimer interface [polypeptide binding]; other site
1097668021177	active site
1097668021178	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1097668021179	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1097668021180	Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968
1097668021181	acyl-activating enzyme (AAE) consensus motif; other site
1097668021182	putative AMP binding site [chemical binding]; other site
1097668021183	putative active site [active]
1097668021184	putative CoA binding site [chemical binding]; other site
1097668021185	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021186	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021187	benzoate transport; Region: 2A0115; TIGR00895
1097668021188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021189	putative substrate translocation pore; other site
1097668021190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021191	choline dehydrogenase; Validated; Region: PRK02106
1097668021192	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668021193	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
1097668021194	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668021195	NAD binding site [chemical binding]; other site
1097668021196	catalytic residues [active]
1097668021197	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668021198	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021199	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668021200	dimerization interface [polypeptide binding]; other site
1097668021201	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021202	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021203	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021204	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021205	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
1097668021206	DUF35 OB-fold domain; Region: DUF35; pfam01796
1097668021207	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1097668021208	active site
1097668021209	MoaC_like    Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446
1097668021210	homodimer interaction site [polypeptide binding]; other site
1097668021211	putative active site [active]
1097668021212	putative catalytic site [active]
1097668021213	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668021214	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668021215	active site
1097668021216	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021217	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021218	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668021219	Ligand binding site [chemical binding]; other site
1097668021220	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668021221	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668021222	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668021223	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668021224	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
1097668021225	classical (c) SDRs; Region: SDR_c; cd05233
1097668021226	NAD(P) binding site [chemical binding]; other site
1097668021227	active site
1097668021228	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668021229	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668021230	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1097668021231	substrate binding site [chemical binding]; other site
1097668021232	oxyanion hole (OAH) forming residues; other site
1097668021233	trimer interface [polypeptide binding]; other site
1097668021234	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1097668021235	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1097668021236	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1097668021237	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1097668021238	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1097668021239	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021240	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021241	Uncharacterized conserved protein [Function unknown]; Region: COG3777
1097668021242	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668021243	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668021244	active site 2 [active]
1097668021245	active site 1 [active]
1097668021246	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1097668021247	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668021248	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668021249	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668021250	Ligand binding site [chemical binding]; other site
1097668021251	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668021252	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668021253	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1097668021254	active site
1097668021255	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668021256	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021257	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
1097668021258	putative dimerization interface [polypeptide binding]; other site
1097668021259	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1097668021260	putative FMN binding site [chemical binding]; other site
1097668021261	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021262	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021263	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021264	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021265	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668021266	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668021267	active site
1097668021268	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1097668021269	putative active site [active]
1097668021270	putative catalytic site [active]
1097668021271	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1097668021272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021273	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668021274	putative substrate translocation pore; other site
1097668021275	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668021276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668021277	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668021278	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1097668021279	SnoaL-like domain; Region: SnoaL_3; pfam13474
1097668021280	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668021281	benzoate transport; Region: 2A0115; TIGR00895
1097668021282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021283	putative substrate translocation pore; other site
1097668021284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021285	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668021286	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021287	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668021288	putative dimerization interface [polypeptide binding]; other site
1097668021289	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021290	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021291	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021292	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1097668021293	NAD(P) binding site [chemical binding]; other site
1097668021294	active site
1097668021295	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1097668021296	HPr interaction site; other site
1097668021297	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1097668021298	active site
1097668021299	phosphorylation site [posttranslational modification]
1097668021300	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1097668021301	regulatory protein interface [polypeptide binding]; other site
1097668021302	active site
1097668021303	regulatory phosphorylation site [posttranslational modification]; other site
1097668021304	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1097668021305	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1097668021306	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1097668021307	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1097668021308	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
1097668021309	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1097668021310	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1097668021311	active site turn [active]
1097668021312	phosphorylation site [posttranslational modification]
1097668021313	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1097668021314	active site turn [active]
1097668021315	phosphorylation site [posttranslational modification]
1097668021316	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
1097668021317	benzoate transporter; Region: benE; TIGR00843
1097668021318	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668021319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021320	putative substrate translocation pore; other site
1097668021321	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1097668021322	MarR family; Region: MarR; pfam01047
1097668021323	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021324	putative substrate translocation pore; other site
1097668021325	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
1097668021326	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668021327	catalytic triad [active]
1097668021328	substrate binding site [chemical binding]; other site
1097668021329	domain interfaces; other site
1097668021330	conserved cis-peptide bond; other site
1097668021331	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668021332	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1097668021333	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668021334	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1097668021335	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1097668021336	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668021337	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668021338	catalytic loop [active]
1097668021339	iron binding site [ion binding]; other site
1097668021340	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668021341	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
1097668021342	putative hydrophobic ligand binding site [chemical binding]; other site
1097668021343	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
1097668021344	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668021345	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668021346	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668021347	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1097668021348	inter-subunit interface; other site
1097668021349	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668021350	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1097668021351	iron-sulfur cluster [ion binding]; other site
1097668021352	[2Fe-2S] cluster binding site [ion binding]; other site
1097668021353	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
1097668021354	putative alpha subunit interface [polypeptide binding]; other site
1097668021355	putative active site [active]
1097668021356	putative substrate binding site [chemical binding]; other site
1097668021357	Fe binding site [ion binding]; other site
1097668021358	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1097668021359	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668021360	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1097668021361	[2Fe-2S] cluster binding site [ion binding]; other site
1097668021362	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097668021363	EamA-like transporter family; Region: EamA; pfam00892
1097668021364	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1097668021365	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
1097668021366	dimer interface [polypeptide binding]; other site
1097668021367	active site
1097668021368	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668021369	substrate binding site [chemical binding]; other site
1097668021370	catalytic residue [active]
1097668021371	Protein of unknown function (DUF3325); Region: DUF3325; pfam11804
1097668021372	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1097668021373	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
1097668021374	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1097668021375	RibD C-terminal domain; Region: RibD_C; cl17279
1097668021376	Protein of unknown function (DUF3182); Region: DUF3182; pfam11379
1097668021377	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668021378	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668021379	Hemerythrin-like domain; Region: Hr-like; cd12108
1097668021380	Fe binding site [ion binding]; other site
1097668021381	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1097668021382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668021383	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668021384	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668021385	putative transposase OrfB; Reviewed; Region: PHA02517
1097668021386	HTH-like domain; Region: HTH_21; pfam13276
1097668021387	Integrase core domain; Region: rve; pfam00665
1097668021388	Integrase core domain; Region: rve_2; pfam13333
1097668021389	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
1097668021390	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1097668021391	Clp amino terminal domain; Region: Clp_N; pfam02861
1097668021392	Clp amino terminal domain; Region: Clp_N; pfam02861
1097668021393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668021394	Walker A motif; other site
1097668021395	ATP binding site [chemical binding]; other site
1097668021396	Walker B motif; other site
1097668021397	arginine finger; other site
1097668021398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668021399	Walker A motif; other site
1097668021400	ATP binding site [chemical binding]; other site
1097668021401	Walker B motif; other site
1097668021402	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1097668021403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021404	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668021405	putative substrate translocation pore; other site
1097668021406	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1097668021407	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1097668021408	active site
1097668021409	tetramer interface [polypeptide binding]; other site
1097668021410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668021411	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
1097668021412	DNA-binding site [nucleotide binding]; DNA binding site
1097668021413	FCD domain; Region: FCD; pfam07729
1097668021414	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668021415	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1097668021416	[2Fe-2S] cluster binding site [ion binding]; other site
1097668021417	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1097668021418	putative alpha subunit interface [polypeptide binding]; other site
1097668021419	putative active site [active]
1097668021420	putative substrate binding site [chemical binding]; other site
1097668021421	Fe binding site [ion binding]; other site
1097668021422	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668021423	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021424	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668021425	dimerization interface [polypeptide binding]; other site
1097668021426	substrate binding pocket [chemical binding]; other site
1097668021427	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1097668021428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021429	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668021430	dimerization interface [polypeptide binding]; other site
1097668021431	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476
1097668021432	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1097668021433	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668021434	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1097668021435	NAD(P) binding site [chemical binding]; other site
1097668021436	catalytic residues [active]
1097668021437	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668021438	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668021439	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668021440	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668021441	inhibitor site; inhibition site
1097668021442	active site
1097668021443	dimer interface [polypeptide binding]; other site
1097668021444	catalytic residue [active]
1097668021445	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1097668021446	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1097668021447	dimer interface [polypeptide binding]; other site
1097668021448	active site
1097668021449	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1097668021450	folate binding site [chemical binding]; other site
1097668021451	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
1097668021452	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1097668021453	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
1097668021454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668021455	dimer interface [polypeptide binding]; other site
1097668021456	conserved gate region; other site
1097668021457	ABC-ATPase subunit interface; other site
1097668021458	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1097668021459	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1097668021460	Walker A/P-loop; other site
1097668021461	ATP binding site [chemical binding]; other site
1097668021462	Q-loop/lid; other site
1097668021463	ABC transporter signature motif; other site
1097668021464	Walker B; other site
1097668021465	D-loop; other site
1097668021466	H-loop/switch region; other site
1097668021467	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1097668021468	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1097668021469	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1097668021470	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1097668021471	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668021472	catalytic residues [active]
1097668021473	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1097668021474	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668021475	catalytic residues [active]
1097668021476	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1097668021477	Sodium Bile acid symporter family; Region: SBF; pfam01758
1097668021478	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1097668021479	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668021480	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668021481	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1097668021482	dimerization interface [polypeptide binding]; other site
1097668021483	putative DNA binding site [nucleotide binding]; other site
1097668021484	putative Zn2+ binding site [ion binding]; other site
1097668021485	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1097668021486	putative hydrophobic ligand binding site [chemical binding]; other site
1097668021487	pyruvate dehydrogenase; Provisional; Region: PRK09124
1097668021488	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1097668021489	PYR/PP interface [polypeptide binding]; other site
1097668021490	dimer interface [polypeptide binding]; other site
1097668021491	tetramer interface [polypeptide binding]; other site
1097668021492	TPP binding site [chemical binding]; other site
1097668021493	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668021494	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1097668021495	TPP-binding site [chemical binding]; other site
1097668021496	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668021497	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668021498	substrate binding pocket [chemical binding]; other site
1097668021499	membrane-bound complex binding site; other site
1097668021500	hinge residues; other site
1097668021501	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1097668021502	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1097668021503	Walker A/P-loop; other site
1097668021504	ATP binding site [chemical binding]; other site
1097668021505	Q-loop/lid; other site
1097668021506	ABC transporter signature motif; other site
1097668021507	Walker B; other site
1097668021508	D-loop; other site
1097668021509	H-loop/switch region; other site
1097668021510	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668021511	dimer interface [polypeptide binding]; other site
1097668021512	conserved gate region; other site
1097668021513	putative PBP binding loops; other site
1097668021514	ABC-ATPase subunit interface; other site
1097668021515	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1097668021516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668021517	dimer interface [polypeptide binding]; other site
1097668021518	conserved gate region; other site
1097668021519	putative PBP binding loops; other site
1097668021520	ABC-ATPase subunit interface; other site
1097668021521	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668021522	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021523	NAD(P) binding site [chemical binding]; other site
1097668021524	active site
1097668021525	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1097668021526	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668021527	DNA-binding site [nucleotide binding]; DNA binding site
1097668021528	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1097668021529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021530	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668021531	putative substrate translocation pore; other site
1097668021532	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097668021533	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1097668021534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021535	NAD(P) binding site [chemical binding]; other site
1097668021536	active site
1097668021537	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1097668021538	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668021539	DNA binding site [nucleotide binding]
1097668021540	domain linker motif; other site
1097668021541	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1097668021542	ligand binding site [chemical binding]; other site
1097668021543	dimerization interface [polypeptide binding]; other site
1097668021544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021545	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668021546	putative substrate translocation pore; other site
1097668021547	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097668021548	EamA-like transporter family; Region: EamA; pfam00892
1097668021549	EamA-like transporter family; Region: EamA; pfam00892
1097668021550	Cache domain; Region: Cache_1; pfam02743
1097668021551	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668021552	dimerization interface [polypeptide binding]; other site
1097668021553	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1097668021554	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668021555	dimer interface [polypeptide binding]; other site
1097668021556	putative CheW interface [polypeptide binding]; other site
1097668021557	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1097668021558	[2Fe-2S] cluster binding site [ion binding]; other site
1097668021559	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1097668021560	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
1097668021561	putative di-iron ligands [ion binding]; other site
1097668021562	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1097668021563	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1097668021564	DNA binding site [nucleotide binding]
1097668021565	domain linker motif; other site
1097668021566	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1097668021567	putative ligand binding site [chemical binding]; other site
1097668021568	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1097668021569	active site
1097668021570	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668021571	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668021572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021573	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1097668021574	NAD(P) binding site [chemical binding]; other site
1097668021575	active site
1097668021576	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1097668021577	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1097668021578	hypothetical protein; Provisional; Region: PRK06486
1097668021579	intersubunit interface [polypeptide binding]; other site
1097668021580	active site
1097668021581	Zn2+ binding site [ion binding]; other site
1097668021582	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668021583	DNA-binding site [nucleotide binding]; DNA binding site
1097668021584	RNA-binding motif; other site
1097668021585	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1097668021586	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668021587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021588	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668021589	putative dimerization interface [polypeptide binding]; other site
1097668021590	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1097668021591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
1097668021592	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668021593	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1097668021594	catalytic site [active]
1097668021595	Cache domain; Region: Cache_1; pfam02743
1097668021596	PAS domain S-box; Region: sensory_box; TIGR00229
1097668021597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668021598	putative active site [active]
1097668021599	heme pocket [chemical binding]; other site
1097668021600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668021601	PAS fold; Region: PAS_3; pfam08447
1097668021602	putative active site [active]
1097668021603	heme pocket [chemical binding]; other site
1097668021604	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668021605	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668021606	dimer interface [polypeptide binding]; other site
1097668021607	phosphorylation site [posttranslational modification]
1097668021608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668021609	ATP binding site [chemical binding]; other site
1097668021610	Mg2+ binding site [ion binding]; other site
1097668021611	G-X-G motif; other site
1097668021612	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668021613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668021614	active site
1097668021615	phosphorylation site [posttranslational modification]
1097668021616	intermolecular recognition site; other site
1097668021617	dimerization interface [polypeptide binding]; other site
1097668021618	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668021619	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668021620	active site
1097668021621	phosphorylation site [posttranslational modification]
1097668021622	intermolecular recognition site; other site
1097668021623	dimerization interface [polypeptide binding]; other site
1097668021624	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1097668021625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668021626	active site
1097668021627	phosphorylation site [posttranslational modification]
1097668021628	intermolecular recognition site; other site
1097668021629	dimerization interface [polypeptide binding]; other site
1097668021630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668021631	active site
1097668021632	phosphorylation site [posttranslational modification]
1097668021633	dimerization interface [polypeptide binding]; other site
1097668021634	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1097668021635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668021636	Walker A motif; other site
1097668021637	ATP binding site [chemical binding]; other site
1097668021638	Walker B motif; other site
1097668021639	arginine finger; other site
1097668021640	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668021641	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1097668021642	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1097668021643	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1097668021644	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668021645	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668021646	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1097668021647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021648	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1097668021649	dimerization interface [polypeptide binding]; other site
1097668021650	substrate binding pocket [chemical binding]; other site
1097668021651	benzoate transport; Region: 2A0115; TIGR00895
1097668021652	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021653	putative substrate translocation pore; other site
1097668021654	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1097668021655	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668021656	active site
1097668021657	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668021658	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668021659	tetramer interface [polypeptide binding]; other site
1097668021660	active site
1097668021661	Mg2+/Mn2+ binding site [ion binding]; other site
1097668021662	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668021663	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
1097668021664	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1097668021665	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668021666	motif II; other site
1097668021667	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1097668021668	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021669	NAD(P) binding site [chemical binding]; other site
1097668021670	active site
1097668021671	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1097668021672	active site 1 [active]
1097668021673	dimer interface [polypeptide binding]; other site
1097668021674	hexamer interface [polypeptide binding]; other site
1097668021675	active site 2 [active]
1097668021676	Trehalase; Region: Trehalase; cl17346
1097668021677	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
1097668021678	Helix-turn-helix domain; Region: HTH_18; pfam12833
1097668021679	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668021680	classical (c) SDRs; Region: SDR_c; cd05233
1097668021681	NAD(P) binding site [chemical binding]; other site
1097668021682	active site
1097668021683	putative succinate dehydrogenase; Reviewed; Region: PRK12842
1097668021684	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1097668021685	NIPSNAP; Region: NIPSNAP; pfam07978
1097668021686	benzoate transport; Region: 2A0115; TIGR00895
1097668021687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021688	putative substrate translocation pore; other site
1097668021689	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021690	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1097668021691	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668021692	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021693	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668021694	putative effector binding pocket; other site
1097668021695	dimerization interface [polypeptide binding]; other site
1097668021696	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1097668021697	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668021698	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1097668021699	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1097668021700	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668021701	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668021702	DNA binding residues [nucleotide binding]
1097668021703	citrate-proton symporter; Provisional; Region: PRK15075
1097668021704	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021705	putative substrate translocation pore; other site
1097668021706	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668021707	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668021708	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1097668021709	active site
1097668021710	catalytic residues [active]
1097668021711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668021712	PAS domain; Region: PAS_9; pfam13426
1097668021713	putative active site [active]
1097668021714	heme pocket [chemical binding]; other site
1097668021715	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668021716	PAS domain; Region: PAS_9; pfam13426
1097668021717	putative active site [active]
1097668021718	heme pocket [chemical binding]; other site
1097668021719	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668021720	putative active site [active]
1097668021721	PAS fold; Region: PAS_3; pfam08447
1097668021722	heme pocket [chemical binding]; other site
1097668021723	PAS fold; Region: PAS_3; pfam08447
1097668021724	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1097668021725	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1097668021726	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668021727	dimer interface [polypeptide binding]; other site
1097668021728	phosphorylation site [posttranslational modification]
1097668021729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668021730	ATP binding site [chemical binding]; other site
1097668021731	Mg2+ binding site [ion binding]; other site
1097668021732	G-X-G motif; other site
1097668021733	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668021734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668021735	active site
1097668021736	phosphorylation site [posttranslational modification]
1097668021737	intermolecular recognition site; other site
1097668021738	dimerization interface [polypeptide binding]; other site
1097668021739	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1097668021740	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1097668021741	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668021742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021743	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668021744	dimerization interface [polypeptide binding]; other site
1097668021745	substrate binding pocket [chemical binding]; other site
1097668021746	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668021747	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668021748	NAD(P) binding site [chemical binding]; other site
1097668021749	active site
1097668021750	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668021751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021752	putative substrate translocation pore; other site
1097668021753	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1097668021754	TPP-binding site [chemical binding]; other site
1097668021755	dimer interface [polypeptide binding]; other site
1097668021756	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1097668021757	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1097668021758	PYR/PP interface [polypeptide binding]; other site
1097668021759	dimer interface [polypeptide binding]; other site
1097668021760	TPP binding site [chemical binding]; other site
1097668021761	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668021762	Protein of unknown function (DUF2894); Region: DUF2894; pfam11445
1097668021763	hypothetical protein; Provisional; Region: PRK09040
1097668021764	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1097668021765	ligand binding site [chemical binding]; other site
1097668021766	Domain of unknown function (DUF802); Region: DUF802; pfam05650
1097668021767	Domain of unknown function (DUF802); Region: DUF802; pfam05650
1097668021768	Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
1097668021769	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
1097668021770	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1097668021771	Phosphoesterase family; Region: Phosphoesterase; pfam04185
1097668021772	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1097668021773	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1097668021774	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1097668021775	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1097668021776	FtsX-like permease family; Region: FtsX; pfam02687
1097668021777	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1097668021778	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1097668021779	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1097668021780	Walker A/P-loop; other site
1097668021781	ATP binding site [chemical binding]; other site
1097668021782	Q-loop/lid; other site
1097668021783	ABC transporter signature motif; other site
1097668021784	Walker B; other site
1097668021785	D-loop; other site
1097668021786	H-loop/switch region; other site
1097668021787	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1097668021788	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668021789	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1097668021790	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1097668021791	tartrate dehydrogenase; Region: TTC; TIGR02089
1097668021792	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021793	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668021794	putative substrate translocation pore; other site
1097668021795	Cache domain; Region: Cache_1; pfam02743
1097668021796	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668021797	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668021798	metal binding site [ion binding]; metal-binding site
1097668021799	active site
1097668021800	I-site; other site
1097668021801	LysE type translocator; Region: LysE; cl00565
1097668021802	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1097668021803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668021804	Walker A motif; other site
1097668021805	ATP binding site [chemical binding]; other site
1097668021806	Walker B motif; other site
1097668021807	arginine finger; other site
1097668021808	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668021809	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
1097668021810	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1097668021811	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1097668021812	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
1097668021813	dimer interface [polypeptide binding]; other site
1097668021814	Trp docking motif [polypeptide binding]; other site
1097668021815	active site
1097668021816	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668021817	substrate binding pocket [chemical binding]; other site
1097668021818	membrane-bound complex binding site; other site
1097668021819	hinge residues; other site
1097668021820	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668021821	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668021822	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1097668021823	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
1097668021824	dimer interface [polypeptide binding]; other site
1097668021825	active site
1097668021826	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668021827	substrate binding site [chemical binding]; other site
1097668021828	catalytic residue [active]
1097668021829	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668021830	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668021831	enoyl-CoA hydratase; Provisional; Region: PRK06127
1097668021832	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668021833	substrate binding site [chemical binding]; other site
1097668021834	oxyanion hole (OAH) forming residues; other site
1097668021835	trimer interface [polypeptide binding]; other site
1097668021836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668021837	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668021838	putative substrate translocation pore; other site
1097668021839	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668021840	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668021841	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1097668021842	Cysteine-rich domain; Region: CCG; pfam02754
1097668021843	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1097668021844	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
1097668021845	homodimer interface [polypeptide binding]; other site
1097668021846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668021847	catalytic residue [active]
1097668021848	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668021849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668021850	DNA-binding site [nucleotide binding]; DNA binding site
1097668021851	FCD domain; Region: FCD; pfam07729
1097668021852	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1097668021853	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
1097668021854	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1097668021855	minor groove reading motif; other site
1097668021856	helix-hairpin-helix signature motif; other site
1097668021857	substrate binding pocket [chemical binding]; other site
1097668021858	active site
1097668021859	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1097668021860	NHL repeat; Region: NHL; pfam01436
1097668021861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668021862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668021863	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1097668021864	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1097668021865	dimerization interface [polypeptide binding]; other site
1097668021866	NAD binding site [chemical binding]; other site
1097668021867	ligand binding site [chemical binding]; other site
1097668021868	catalytic site [active]
1097668021869	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1097668021870	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668021871	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1097668021872	putative active site [active]
1097668021873	catalytic site [active]
1097668021874	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1097668021875	putative active site [active]
1097668021876	catalytic site [active]
1097668021877	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668021878	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668021879	active site
1097668021880	catalytic tetrad [active]
1097668021881	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668021882	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1097668021883	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097668021884	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
1097668021885	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1097668021886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1097668021887	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668021888	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1097668021889	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097668021890	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
1097668021891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
1097668021892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307
1097668021893	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
1097668021894	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1097668021895	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1097668021896	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1097668021897	hypothetical protein; Provisional; Region: PRK11239
1097668021898	Protein of unknown function, DUF480; Region: DUF480; pfam04337
1097668021899	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1097668021900	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
1097668021901	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1097668021902	amidase; Provisional; Region: PRK07486
1097668021903	Amidase; Region: Amidase; cl11426
1097668021904	H-NS histone family; Region: Histone_HNS; pfam00816
1097668021905	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1097668021906	Domain of unknown function (DUF3331); Region: DUF3331; pfam11811
1097668021907	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1097668021908	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668021909	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668021910	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668021911	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668021912	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668021913	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668021914	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668021915	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668021916	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668021917	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668021918	catalytic loop [active]
1097668021919	iron binding site [ion binding]; other site
1097668021920	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668021921	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668021922	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668021923	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1097668021924	dimerization interface [polypeptide binding]; other site
1097668021925	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
1097668021926	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097668021927	putative NAD(P) binding site [chemical binding]; other site
1097668021928	Chromate transporter; Region: Chromate_transp; pfam02417
1097668021929	Chromate transporter; Region: Chromate_transp; pfam02417
1097668021930	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1097668021931	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
1097668021932	intersubunit interface [polypeptide binding]; other site
1097668021933	active site
1097668021934	Zn2+ binding site [ion binding]; other site
1097668021935	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
1097668021936	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
1097668021937	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1097668021938	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668021939	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1097668021940	alpha subunit interface [polypeptide binding]; other site
1097668021941	active site
1097668021942	substrate binding site [chemical binding]; other site
1097668021943	Fe binding site [ion binding]; other site
1097668021944	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668021945	MarR family; Region: MarR; pfam01047
1097668021946	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668021947	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668021948	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668021949	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668021950	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668021951	FMN-binding pocket [chemical binding]; other site
1097668021952	flavin binding motif; other site
1097668021953	phosphate binding motif [ion binding]; other site
1097668021954	beta-alpha-beta structure motif; other site
1097668021955	NAD binding pocket [chemical binding]; other site
1097668021956	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668021957	catalytic loop [active]
1097668021958	iron binding site [ion binding]; other site
1097668021959	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
1097668021960	diiron binding motif [ion binding]; other site
1097668021961	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
1097668021962	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668021963	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1097668021964	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668021965	catalytic loop [active]
1097668021966	iron binding site [ion binding]; other site
1097668021967	Toluene-4-monoxygenase electron transfer component of Pseudomonas mendocina hydroxylates toluene and forms p-cresol as part of a three component toluene-4-monoxygenase system. Electron transfer is from NADH to an NADH:ferredoxin oxidoreductase (TmoF in P; Region: T4MO_e_transfer_like; cd06190
1097668021968	FAD binding pocket [chemical binding]; other site
1097668021969	FAD binding motif [chemical binding]; other site
1097668021970	phosphate binding motif [ion binding]; other site
1097668021971	beta-alpha-beta structure motif; other site
1097668021972	NAD binding pocket [chemical binding]; other site
1097668021973	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668021974	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1097668021975	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668021976	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668021977	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668021978	trimer interface [polypeptide binding]; other site
1097668021979	eyelet of channel; other site
1097668021980	NMT1-like family; Region: NMT1_2; pfam13379
1097668021981	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668021982	substrate binding pocket [chemical binding]; other site
1097668021983	membrane-bound complex binding site; other site
1097668021984	hinge residues; other site
1097668021985	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668021986	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668021987	Walker A/P-loop; other site
1097668021988	ATP binding site [chemical binding]; other site
1097668021989	Q-loop/lid; other site
1097668021990	ABC transporter signature motif; other site
1097668021991	Walker B; other site
1097668021992	D-loop; other site
1097668021993	H-loop/switch region; other site
1097668021994	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668021995	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668021996	dimer interface [polypeptide binding]; other site
1097668021997	conserved gate region; other site
1097668021998	putative PBP binding loops; other site
1097668021999	ABC-ATPase subunit interface; other site
1097668022000	Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235
1097668022001	intersubunit interface [polypeptide binding]; other site
1097668022002	active site
1097668022003	Zn2+ binding site [ion binding]; other site
1097668022004	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1097668022005	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1097668022006	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
1097668022007	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1097668022008	[2Fe-2S] cluster binding site [ion binding]; other site
1097668022009	Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479
1097668022010	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668022011	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
1097668022012	alpha subunit interface [polypeptide binding]; other site
1097668022013	active site
1097668022014	substrate binding site [chemical binding]; other site
1097668022015	Fe binding site [ion binding]; other site
1097668022016	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097668022017	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1097668022018	NAD(P) binding site [chemical binding]; other site
1097668022019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022020	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668022021	putative substrate translocation pore; other site
1097668022022	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668022023	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668022024	FMN-binding pocket [chemical binding]; other site
1097668022025	flavin binding motif; other site
1097668022026	phosphate binding motif [ion binding]; other site
1097668022027	beta-alpha-beta structure motif; other site
1097668022028	NAD binding pocket [chemical binding]; other site
1097668022029	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668022030	catalytic loop [active]
1097668022031	iron binding site [ion binding]; other site
1097668022032	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668022033	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668022034	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668022035	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1097668022036	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1097668022037	iron-sulfur cluster [ion binding]; other site
1097668022038	[2Fe-2S] cluster binding site [ion binding]; other site
1097668022039	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1097668022040	hydrophobic ligand binding site; other site
1097668022041	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668022042	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668022043	active site
1097668022044	catalytic tetrad [active]
1097668022045	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1097668022046	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1097668022047	active site
1097668022048	metal binding site [ion binding]; metal-binding site
1097668022049	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1097668022050	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097668022051	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256
1097668022052	putative NAD(P) binding site [chemical binding]; other site
1097668022053	catalytic Zn binding site [ion binding]; other site
1097668022054	structural Zn binding site [ion binding]; other site
1097668022055	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1097668022056	L-idonate 5-dehydrogenase; Region: PLN02702
1097668022057	inhibitor binding site; inhibition site
1097668022058	catalytic Zn binding site [ion binding]; other site
1097668022059	structural Zn binding site [ion binding]; other site
1097668022060	NADP binding site [chemical binding]; other site
1097668022061	tetramer interface [polypeptide binding]; other site
1097668022062	short chain dehydrogenase; Provisional; Region: PRK07060
1097668022063	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668022064	NAD(P) binding site [chemical binding]; other site
1097668022065	active site
1097668022066	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1097668022067	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1097668022068	non-specific DNA interactions [nucleotide binding]; other site
1097668022069	DNA binding site [nucleotide binding]
1097668022070	sequence specific DNA binding site [nucleotide binding]; other site
1097668022071	putative cAMP binding site [chemical binding]; other site
1097668022072	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1097668022073	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1097668022074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668022075	dimer interface [polypeptide binding]; other site
1097668022076	conserved gate region; other site
1097668022077	putative PBP binding loops; other site
1097668022078	ABC-ATPase subunit interface; other site
1097668022079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668022080	dimer interface [polypeptide binding]; other site
1097668022081	conserved gate region; other site
1097668022082	putative PBP binding loops; other site
1097668022083	ABC-ATPase subunit interface; other site
1097668022084	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1097668022085	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1097668022086	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1097668022087	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1097668022088	Walker A/P-loop; other site
1097668022089	ATP binding site [chemical binding]; other site
1097668022090	Q-loop/lid; other site
1097668022091	ABC transporter signature motif; other site
1097668022092	Walker B; other site
1097668022093	D-loop; other site
1097668022094	H-loop/switch region; other site
1097668022095	TOBE domain; Region: TOBE_2; pfam08402
1097668022096	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668022097	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
1097668022098	Peptidase M60-like family; Region: M60-like; pfam13402
1097668022099	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1097668022100	MarR family; Region: MarR; pfam01047
1097668022101	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1097668022102	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022103	putative substrate translocation pore; other site
1097668022104	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022105	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668022106	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1097668022107	P-loop; other site
1097668022108	Magnesium ion binding site [ion binding]; other site
1097668022109	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668022110	Magnesium ion binding site [ion binding]; other site
1097668022111	BON domain; Region: BON; pfam04972
1097668022112	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668022113	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668022114	eyelet of channel; other site
1097668022115	trimer interface [polypeptide binding]; other site
1097668022116	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1097668022117	AAA ATPase domain; Region: AAA_16; pfam13191
1097668022118	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668022119	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668022120	DNA binding residues [nucleotide binding]
1097668022121	dimerization interface [polypeptide binding]; other site
1097668022122	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668022123	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668022124	active site
1097668022125	lipid-transfer protein; Provisional; Region: PRK08256
1097668022126	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1097668022127	active site
1097668022128	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1097668022129	active site
1097668022130	catalytic site [active]
1097668022131	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1097668022132	active site
1097668022133	catalytic site [active]
1097668022134	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668022135	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668022136	NAD(P) binding site [chemical binding]; other site
1097668022137	active site
1097668022138	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1097668022139	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1097668022140	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1097668022141	acyl-activating enzyme (AAE) consensus motif; other site
1097668022142	acyl-activating enzyme (AAE) consensus motif; other site
1097668022143	putative AMP binding site [chemical binding]; other site
1097668022144	putative active site [active]
1097668022145	putative CoA binding site [chemical binding]; other site
1097668022146	enoyl-CoA hydratase; Provisional; Region: PRK08140
1097668022147	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668022148	substrate binding site [chemical binding]; other site
1097668022149	oxyanion hole (OAH) forming residues; other site
1097668022150	trimer interface [polypeptide binding]; other site
1097668022151	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1097668022152	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668022153	classical (c) SDRs; Region: SDR_c; cd05233
1097668022154	NAD(P) binding site [chemical binding]; other site
1097668022155	active site
1097668022156	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1097668022157	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097668022158	NAD(P) binding site [chemical binding]; other site
1097668022159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022160	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668022161	putative substrate translocation pore; other site
1097668022162	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1097668022163	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668022164	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
1097668022165	classical (c) SDRs; Region: SDR_c; cd05233
1097668022166	NAD(P) binding site [chemical binding]; other site
1097668022167	active site
1097668022168	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1097668022169	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668022170	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1097668022171	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668022172	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1097668022173	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1097668022174	active site
1097668022175	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1097668022176	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1097668022177	FAD binding site [chemical binding]; other site
1097668022178	substrate binding site [chemical binding]; other site
1097668022179	catalytic base [active]
1097668022180	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
1097668022181	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1097668022182	active site
1097668022183	oxalacetate binding site [chemical binding]; other site
1097668022184	citrylCoA binding site [chemical binding]; other site
1097668022185	coenzyme A binding site [chemical binding]; other site
1097668022186	catalytic triad [active]
1097668022187	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668022188	active site 2 [active]
1097668022189	active site 1 [active]
1097668022190	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668022191	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668022192	active site
1097668022193	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668022194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668022195	NAD(P) binding site [chemical binding]; other site
1097668022196	active site
1097668022197	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1097668022198	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1097668022199	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1097668022200	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668022201	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668022202	metal binding site [ion binding]; metal-binding site
1097668022203	active site
1097668022204	I-site; other site
1097668022205	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668022206	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
1097668022207	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1097668022208	putative active site [active]
1097668022209	catalytic site [active]
1097668022210	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
1097668022211	putative active site [active]
1097668022212	catalytic site [active]
1097668022213	Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
1097668022214	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1097668022215	classical (c) SDRs; Region: SDR_c; cd05233
1097668022216	NAD(P) binding site [chemical binding]; other site
1097668022217	active site
1097668022218	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
1097668022219	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1097668022220	Fe-S cluster binding site [ion binding]; other site
1097668022221	active site
1097668022222	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
1097668022223	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1097668022224	FeS/SAM binding site; other site
1097668022225	proline/glycine betaine transporter; Provisional; Region: PRK10642
1097668022226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022227	putative substrate translocation pore; other site
1097668022228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668022229	binding surface
1097668022230	TPR motif; other site
1097668022231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1097668022232	binding surface
1097668022233	TPR motif; other site
1097668022234	TPR repeat; Region: TPR_11; pfam13414
1097668022235	GAF domain; Region: GAF_3; pfam13492
1097668022236	GAF domain; Region: GAF_2; pfam13185
1097668022237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668022238	dimer interface [polypeptide binding]; other site
1097668022239	phosphorylation site [posttranslational modification]
1097668022240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1097668022241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668022242	ATP binding site [chemical binding]; other site
1097668022243	Mg2+ binding site [ion binding]; other site
1097668022244	G-X-G motif; other site
1097668022245	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668022246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668022247	active site
1097668022248	phosphorylation site [posttranslational modification]
1097668022249	intermolecular recognition site; other site
1097668022250	dimerization interface [polypeptide binding]; other site
1097668022251	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1097668022252	GAF domain; Region: GAF; pfam01590
1097668022253	PAS domain S-box; Region: sensory_box; TIGR00229
1097668022254	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668022255	putative active site [active]
1097668022256	heme pocket [chemical binding]; other site
1097668022257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668022258	dimer interface [polypeptide binding]; other site
1097668022259	phosphorylation site [posttranslational modification]
1097668022260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668022261	ATP binding site [chemical binding]; other site
1097668022262	Mg2+ binding site [ion binding]; other site
1097668022263	G-X-G motif; other site
1097668022264	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668022265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668022266	active site
1097668022267	phosphorylation site [posttranslational modification]
1097668022268	intermolecular recognition site; other site
1097668022269	dimerization interface [polypeptide binding]; other site
1097668022270	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668022271	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668022272	active site
1097668022273	phosphorylation site [posttranslational modification]
1097668022274	intermolecular recognition site; other site
1097668022275	dimerization interface [polypeptide binding]; other site
1097668022276	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1097668022277	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1097668022278	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1097668022279	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1097668022280	motif II; other site
1097668022281	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1097668022282	active site
1097668022283	catalytic residues [active]
1097668022284	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668022285	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668022286	trimer interface [polypeptide binding]; other site
1097668022287	eyelet of channel; other site
1097668022288	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1097668022289	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1097668022290	Walker A/P-loop; other site
1097668022291	ATP binding site [chemical binding]; other site
1097668022292	Q-loop/lid; other site
1097668022293	ABC transporter signature motif; other site
1097668022294	Walker B; other site
1097668022295	D-loop; other site
1097668022296	H-loop/switch region; other site
1097668022297	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1097668022298	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1097668022299	Walker A/P-loop; other site
1097668022300	ATP binding site [chemical binding]; other site
1097668022301	Q-loop/lid; other site
1097668022302	ABC transporter signature motif; other site
1097668022303	Walker B; other site
1097668022304	D-loop; other site
1097668022305	H-loop/switch region; other site
1097668022306	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1097668022307	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1097668022308	TM-ABC transporter signature motif; other site
1097668022309	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668022310	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1097668022311	TM-ABC transporter signature motif; other site
1097668022312	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1097668022313	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345
1097668022314	putative ligand binding site [chemical binding]; other site
1097668022315	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668022316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668022317	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668022318	dimerization interface [polypeptide binding]; other site
1097668022319	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1097668022320	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668022321	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668022322	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1097668022323	putative C-terminal domain interface [polypeptide binding]; other site
1097668022324	putative GSH binding site (G-site) [chemical binding]; other site
1097668022325	putative dimer interface [polypeptide binding]; other site
1097668022326	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668022327	N-terminal domain interface [polypeptide binding]; other site
1097668022328	dimer interface [polypeptide binding]; other site
1097668022329	substrate binding pocket (H-site) [chemical binding]; other site
1097668022330	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1097668022331	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1097668022332	C-terminal domain interface [polypeptide binding]; other site
1097668022333	GSH binding site (G-site) [chemical binding]; other site
1097668022334	dimer interface [polypeptide binding]; other site
1097668022335	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668022336	N-terminal domain interface [polypeptide binding]; other site
1097668022337	dimer interface [polypeptide binding]; other site
1097668022338	substrate binding pocket (H-site) [chemical binding]; other site
1097668022339	acyl-CoA synthetase; Validated; Region: PRK08162
1097668022340	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
1097668022341	acyl-activating enzyme (AAE) consensus motif; other site
1097668022342	putative active site [active]
1097668022343	AMP binding site [chemical binding]; other site
1097668022344	putative CoA binding site [chemical binding]; other site
1097668022345	enoyl-CoA hydratase; Validated; Region: PRK08139
1097668022346	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668022347	substrate binding site [chemical binding]; other site
1097668022348	oxyanion hole (OAH) forming residues; other site
1097668022349	trimer interface [polypeptide binding]; other site
1097668022350	Protein of unknown function (DUF779); Region: DUF779; pfam05610
1097668022351	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1097668022352	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668022353	NAD(P) binding site [chemical binding]; other site
1097668022354	catalytic residues [active]
1097668022355	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1097668022356	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1097668022357	Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693
1097668022358	High potential iron-sulfur protein; Region: HIPIP; pfam01355
1097668022359	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
1097668022360	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1097668022361	putative catalytic site [active]
1097668022362	putative metal binding site [ion binding]; other site
1097668022363	putative phosphate binding site [ion binding]; other site
1097668022364	putative catalytic site [active]
1097668022365	putative phosphate binding site [ion binding]; other site
1097668022366	putative metal binding site [ion binding]; other site
1097668022367	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
1097668022368	putative active site [active]
1097668022369	Zn binding site [ion binding]; other site
1097668022370	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1097668022371	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1097668022372	metal binding site [ion binding]; metal-binding site
1097668022373	putative dimer interface [polypeptide binding]; other site
1097668022374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668022375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668022376	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668022377	dimerization interface [polypeptide binding]; other site
1097668022378	citrate-proton symporter; Provisional; Region: PRK15075
1097668022379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022380	putative substrate translocation pore; other site
1097668022381	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1097668022382	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668022383	catalytic loop [active]
1097668022384	iron binding site [ion binding]; other site
1097668022385	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1097668022386	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
1097668022387	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1097668022388	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1097668022389	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1097668022390	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1097668022391	hypothetical protein; Provisional; Region: PRK10396
1097668022392	yecA family protein; Region: ygfB_yecA; TIGR02292
1097668022393	SEC-C motif; Region: SEC-C; pfam02810
1097668022394	Uncharacterized conserved protein [Function unknown]; Region: COG2361
1097668022395	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1097668022396	active site
1097668022397	4-oxalocrotonate tautomerase; Provisional; Region: PRK00745
1097668022398	active site 1 [active]
1097668022399	dimer interface [polypeptide binding]; other site
1097668022400	hexamer interface [polypeptide binding]; other site
1097668022401	active site 2 [active]
1097668022402	aldolase II superfamily protein; Provisional; Region: PRK07044
1097668022403	intersubunit interface [polypeptide binding]; other site
1097668022404	active site
1097668022405	Zn2+ binding site [ion binding]; other site
1097668022406	Urea transporter; Region: UT; cl01829
1097668022407	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668022408	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
1097668022409	putative active site [active]
1097668022410	metal binding site [ion binding]; metal-binding site
1097668022411	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1097668022412	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1097668022413	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1097668022414	active site
1097668022415	cosubstrate binding site; other site
1097668022416	substrate binding site [chemical binding]; other site
1097668022417	catalytic site [active]
1097668022418	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1097668022419	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1097668022420	N-terminal plug; other site
1097668022421	ligand-binding site [chemical binding]; other site
1097668022422	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
1097668022423	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668022424	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668022425	Condensation domain; Region: Condensation; pfam00668
1097668022426	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097668022427	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668022428	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668022429	acyl-activating enzyme (AAE) consensus motif; other site
1097668022430	AMP binding site [chemical binding]; other site
1097668022431	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668022432	Condensation domain; Region: Condensation; pfam00668
1097668022433	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097668022434	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668022435	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668022436	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668022437	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1097668022438	acyl-activating enzyme (AAE) consensus motif; other site
1097668022439	AMP binding site [chemical binding]; other site
1097668022440	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668022441	Condensation domain; Region: Condensation; pfam00668
1097668022442	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097668022443	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1097668022444	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668022445	acyl-activating enzyme (AAE) consensus motif; other site
1097668022446	AMP binding site [chemical binding]; other site
1097668022447	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668022448	Condensation domain; Region: Condensation; pfam00668
1097668022449	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1097668022450	Condensation domain; Region: Condensation; pfam00668
1097668022451	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1097668022452	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1097668022453	acyl-activating enzyme (AAE) consensus motif; other site
1097668022454	AMP binding site [chemical binding]; other site
1097668022455	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1097668022456	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
1097668022457	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1097668022458	Walker A/P-loop; other site
1097668022459	ATP binding site [chemical binding]; other site
1097668022460	Q-loop/lid; other site
1097668022461	ABC transporter signature motif; other site
1097668022462	Walker B; other site
1097668022463	D-loop; other site
1097668022464	H-loop/switch region; other site
1097668022465	galactarate dehydratase; Region: galactar-dH20; TIGR03248
1097668022466	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1097668022467	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1097668022468	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
1097668022469	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668022470	putative active site [active]
1097668022471	catalytic residue [active]
1097668022472	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022473	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668022474	putative substrate translocation pore; other site
1097668022475	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
1097668022476	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1097668022477	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1097668022478	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1097668022479	MOSC domain; Region: MOSC; pfam03473
1097668022480	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
1097668022481	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668022482	Proline racemase; Region: Pro_racemase; pfam05544
1097668022483	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668022484	Coenzyme A binding pocket [chemical binding]; other site
1097668022485	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1097668022486	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1097668022487	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668022488	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668022489	DNA-binding site [nucleotide binding]; DNA binding site
1097668022490	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668022491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668022492	homodimer interface [polypeptide binding]; other site
1097668022493	catalytic residue [active]
1097668022494	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668022495	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1097668022496	NAD(P) binding site [chemical binding]; other site
1097668022497	active site
1097668022498	Cation efflux family; Region: Cation_efflux; cl00316
1097668022499	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1097668022500	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1097668022501	Heavy-metal-associated domain; Region: HMA; pfam00403
1097668022502	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1097668022503	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1097668022504	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
1097668022505	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
1097668022506	DNA binding residues [nucleotide binding]
1097668022507	dimer interface [polypeptide binding]; other site
1097668022508	putative metal binding site [ion binding]; other site
1097668022509	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1097668022510	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668022511	Uncharacterized conserved protein [Function unknown]; Region: COG5476
1097668022512	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
1097668022513	MlrC C-terminus; Region: MlrC_C; pfam07171
1097668022514	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668022515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022516	putative substrate translocation pore; other site
1097668022517	H+ Antiporter protein; Region: 2A0121; TIGR00900
1097668022518	PAS fold; Region: PAS_4; pfam08448
1097668022519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668022520	PAS fold; Region: PAS_3; pfam08447
1097668022521	putative active site [active]
1097668022522	heme pocket [chemical binding]; other site
1097668022523	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668022524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668022525	metal binding site [ion binding]; metal-binding site
1097668022526	active site
1097668022527	I-site; other site
1097668022528	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1097668022529	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1097668022530	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668022531	Tar ligand binding domain homologue; Region: TarH; pfam02203
1097668022532	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1097668022533	HAMP domain; Region: HAMP; pfam00672
1097668022534	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668022535	dimer interface [polypeptide binding]; other site
1097668022536	putative CheW interface [polypeptide binding]; other site
1097668022537	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668022538	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668022539	inhibitor site; inhibition site
1097668022540	active site
1097668022541	dimer interface [polypeptide binding]; other site
1097668022542	catalytic residue [active]
1097668022543	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668022544	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668022545	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1097668022546	dimerization interface [polypeptide binding]; other site
1097668022547	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1097668022548	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1097668022549	active site
1097668022550	FMN binding site [chemical binding]; other site
1097668022551	substrate binding site [chemical binding]; other site
1097668022552	homotetramer interface [polypeptide binding]; other site
1097668022553	catalytic residue [active]
1097668022554	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1097668022555	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668022556	hypothetical protein; Provisional; Region: PRK09262
1097668022557	Amidohydrolase; Region: Amidohydro_2; pfam04909
1097668022558	benzoate transport; Region: 2A0115; TIGR00895
1097668022559	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022560	putative substrate translocation pore; other site
1097668022561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022562	protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367
1097668022563	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
1097668022564	active site
1097668022565	metal binding site [ion binding]; metal-binding site
1097668022566	The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923
1097668022567	putative dimer interface [polypeptide binding]; other site
1097668022568	putative N- and C-terminal domain interface [polypeptide binding]; other site
1097668022569	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097668022570	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668022571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668022572	active site
1097668022573	phosphorylation site [posttranslational modification]
1097668022574	intermolecular recognition site; other site
1097668022575	dimerization interface [polypeptide binding]; other site
1097668022576	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1097668022577	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1097668022578	putative CheW interface [polypeptide binding]; other site
1097668022579	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668022580	dimerization interface [polypeptide binding]; other site
1097668022581	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1097668022582	putative binding surface; other site
1097668022583	active site
1097668022584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668022585	ATP binding site [chemical binding]; other site
1097668022586	Mg2+ binding site [ion binding]; other site
1097668022587	G-X-G motif; other site
1097668022588	FOG: CBS domain [General function prediction only]; Region: COG0517
1097668022589	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
1097668022590	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1097668022591	BON domain; Region: BON; cl02771
1097668022592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668022593	PAS domain; Region: PAS_9; pfam13426
1097668022594	putative active site [active]
1097668022595	heme pocket [chemical binding]; other site
1097668022596	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1097668022597	Histidine kinase; Region: HisKA_3; pfam07730
1097668022598	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668022599	ATP binding site [chemical binding]; other site
1097668022600	Mg2+ binding site [ion binding]; other site
1097668022601	G-X-G motif; other site
1097668022602	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668022603	Ligand Binding Site [chemical binding]; other site
1097668022604	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668022605	Ligand Binding Site [chemical binding]; other site
1097668022606	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1097668022607	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
1097668022608	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097668022609	catalytic Zn binding site [ion binding]; other site
1097668022610	structural Zn binding site [ion binding]; other site
1097668022611	NAD(P) binding site [chemical binding]; other site
1097668022612	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1097668022613	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1097668022614	FMN binding site [chemical binding]; other site
1097668022615	substrate binding site [chemical binding]; other site
1097668022616	putative catalytic residue [active]
1097668022617	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668022618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668022619	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668022620	putative effector binding pocket; other site
1097668022621	dimerization interface [polypeptide binding]; other site
1097668022622	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1097668022623	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1097668022624	tetrameric interface [polypeptide binding]; other site
1097668022625	NAD binding site [chemical binding]; other site
1097668022626	catalytic residues [active]
1097668022627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668022628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668022629	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668022630	putative effector binding pocket; other site
1097668022631	dimerization interface [polypeptide binding]; other site
1097668022632	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668022633	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1097668022634	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1097668022635	catalytic residue [active]
1097668022636	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1097668022637	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1097668022638	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1097668022639	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1097668022640	catalytic site [active]
1097668022641	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668022642	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668022643	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668022644	dimerization interface [polypeptide binding]; other site
1097668022645	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1097668022646	active site lid residues [active]
1097668022647	substrate binding pocket [chemical binding]; other site
1097668022648	catalytic residues [active]
1097668022649	substrate-Mg2+ binding site; other site
1097668022650	aspartate-rich region 1; other site
1097668022651	aspartate-rich region 2; other site
1097668022652	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1097668022653	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668022654	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1097668022655	C-terminal domain interface [polypeptide binding]; other site
1097668022656	GSH binding site (G-site) [chemical binding]; other site
1097668022657	dimer interface [polypeptide binding]; other site
1097668022658	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1097668022659	N-terminal domain interface [polypeptide binding]; other site
1097668022660	dimer interface [polypeptide binding]; other site
1097668022661	substrate binding pocket (H-site) [chemical binding]; other site
1097668022662	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668022663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1097668022664	active site
1097668022665	phosphorylation site [posttranslational modification]
1097668022666	intermolecular recognition site; other site
1097668022667	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1097668022668	MgtC family; Region: MgtC; pfam02308
1097668022669	GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080
1097668022670	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668022671	putative C-terminal domain interface [polypeptide binding]; other site
1097668022672	putative GSH binding site [chemical binding]; other site
1097668022673	putative dimer interface [polypeptide binding]; other site
1097668022674	C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193
1097668022675	putative N-terminal domain interface [polypeptide binding]; other site
1097668022676	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
1097668022677	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1097668022678	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1097668022679	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1097668022680	putative NADH binding site [chemical binding]; other site
1097668022681	putative active site [active]
1097668022682	nudix motif; other site
1097668022683	putative metal binding site [ion binding]; other site
1097668022684	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1097668022685	catalytic core [active]
1097668022686	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1097668022687	MarC family integral membrane protein; Region: MarC; cl00919
1097668022688	Flagellar regulator YcgR; Region: YcgR; pfam07317
1097668022689	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1097668022690	PilZ domain; Region: PilZ; pfam07238
1097668022691	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668022692	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1097668022693	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668022694	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668022695	DNA binding residues [nucleotide binding]
1097668022696	dimerization interface [polypeptide binding]; other site
1097668022697	galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288
1097668022698	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668022699	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668022700	hypothetical protein; Provisional; Region: PRK09936
1097668022701	Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283
1097668022702	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
1097668022703	active site
1097668022704	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
1097668022705	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1097668022706	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
1097668022707	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1097668022708	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1097668022709	homodimer interface [polypeptide binding]; other site
1097668022710	active site
1097668022711	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1097668022712	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1097668022713	putative NAD(P) binding site [chemical binding]; other site
1097668022714	putative substrate binding site [chemical binding]; other site
1097668022715	catalytic Zn binding site [ion binding]; other site
1097668022716	structural Zn binding site [ion binding]; other site
1097668022717	dimer interface [polypeptide binding]; other site
1097668022718	Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796
1097668022719	NapD protein; Region: NapD; pfam03927
1097668022720	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1097668022721	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1097668022722	[4Fe-4S] binding site [ion binding]; other site
1097668022723	molybdopterin cofactor binding site; other site
1097668022724	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1097668022725	molybdopterin cofactor binding site; other site
1097668022726	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
1097668022727	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
1097668022728	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
1097668022729	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1097668022730	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668022731	Walker A/P-loop; other site
1097668022732	ATP binding site [chemical binding]; other site
1097668022733	Q-loop/lid; other site
1097668022734	ABC transporter signature motif; other site
1097668022735	Walker B; other site
1097668022736	D-loop; other site
1097668022737	H-loop/switch region; other site
1097668022738	ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386
1097668022739	heme exporter protein CcmC; Region: ccmC; TIGR01191
1097668022740	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1097668022741	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1097668022742	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1097668022743	catalytic residues [active]
1097668022744	central insert; other site
1097668022745	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1097668022746	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1097668022747	Protein of unknown function (DUF3079); Region: DUF3079; pfam11278
1097668022748	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1097668022749	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1097668022750	FMN binding site [chemical binding]; other site
1097668022751	substrate binding site [chemical binding]; other site
1097668022752	putative catalytic residue [active]
1097668022753	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668022754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668022755	active site
1097668022756	phosphorylation site [posttranslational modification]
1097668022757	intermolecular recognition site; other site
1097668022758	dimerization interface [polypeptide binding]; other site
1097668022759	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668022760	DNA binding residues [nucleotide binding]
1097668022761	dimerization interface [polypeptide binding]; other site
1097668022762	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
1097668022763	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1097668022764	HAMP domain; Region: HAMP; pfam00672
1097668022765	GAF domain; Region: GAF_3; pfam13492
1097668022766	Histidine kinase; Region: HisKA_3; pfam07730
1097668022767	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668022768	ATP binding site [chemical binding]; other site
1097668022769	Mg2+ binding site [ion binding]; other site
1097668022770	G-X-G motif; other site
1097668022771	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1097668022772	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1097668022773	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1097668022774	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1097668022775	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1097668022776	[4Fe-4S] binding site [ion binding]; other site
1097668022777	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668022778	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668022779	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1097668022780	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1097668022781	molybdopterin cofactor binding site; other site
1097668022782	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1097668022783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022784	putative substrate translocation pore; other site
1097668022785	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1097668022786	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022787	putative substrate translocation pore; other site
1097668022788	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1097668022789	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668022790	Walker A/P-loop; other site
1097668022791	ATP binding site [chemical binding]; other site
1097668022792	Q-loop/lid; other site
1097668022793	ABC transporter signature motif; other site
1097668022794	Walker B; other site
1097668022795	D-loop; other site
1097668022796	H-loop/switch region; other site
1097668022797	TOBE domain; Region: TOBE_2; pfam08402
1097668022798	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1097668022799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668022800	dimer interface [polypeptide binding]; other site
1097668022801	conserved gate region; other site
1097668022802	putative PBP binding loops; other site
1097668022803	ABC-ATPase subunit interface; other site
1097668022804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668022805	dimer interface [polypeptide binding]; other site
1097668022806	conserved gate region; other site
1097668022807	putative PBP binding loops; other site
1097668022808	ABC-ATPase subunit interface; other site
1097668022809	benzoate transport; Region: 2A0115; TIGR00895
1097668022810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022811	putative substrate translocation pore; other site
1097668022812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022813	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1097668022814	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668022815	catalytic loop [active]
1097668022816	iron binding site [ion binding]; other site
1097668022817	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1097668022818	FAD binding pocket [chemical binding]; other site
1097668022819	FAD binding motif [chemical binding]; other site
1097668022820	phosphate binding motif [ion binding]; other site
1097668022821	beta-alpha-beta structure motif; other site
1097668022822	NAD binding pocket [chemical binding]; other site
1097668022823	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1097668022824	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
1097668022825	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
1097668022826	inter-subunit interface; other site
1097668022827	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1097668022828	iron-sulfur cluster [ion binding]; other site
1097668022829	[2Fe-2S] cluster binding site [ion binding]; other site
1097668022830	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
1097668022831	putative alpha subunit interface [polypeptide binding]; other site
1097668022832	putative active site [active]
1097668022833	putative substrate binding site [chemical binding]; other site
1097668022834	Fe binding site [ion binding]; other site
1097668022835	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1097668022836	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668022837	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668022838	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1097668022839	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1097668022840	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1097668022841	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1097668022842	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1097668022843	D-pathway; other site
1097668022844	Putative ubiquinol binding site [chemical binding]; other site
1097668022845	Low-spin heme (heme b) binding site [chemical binding]; other site
1097668022846	Putative water exit pathway; other site
1097668022847	Binuclear center (heme o3/CuB) [ion binding]; other site
1097668022848	K-pathway; other site
1097668022849	Putative proton exit pathway; other site
1097668022850	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1097668022851	Subunit I/III interface [polypeptide binding]; other site
1097668022852	Subunit III/IV interface [polypeptide binding]; other site
1097668022853	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1097668022854	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1097668022855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022856	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668022857	putative substrate translocation pore; other site
1097668022858	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668022859	NAD(P) binding site [chemical binding]; other site
1097668022860	active site
1097668022861	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668022862	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668022863	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668022864	ABC1 family; Region: ABC1; cl17513
1097668022865	ABC1 family; Region: ABC1; cl17513
1097668022866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668022867	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668022868	active site
1097668022869	phosphorylation site [posttranslational modification]
1097668022870	intermolecular recognition site; other site
1097668022871	dimerization interface [polypeptide binding]; other site
1097668022872	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1097668022873	Ligand Binding Site [chemical binding]; other site
1097668022874	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1097668022875	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1097668022876	Bacterial transcriptional regulator; Region: IclR; pfam01614
1097668022877	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
1097668022878	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668022879	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1097668022880	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1097668022881	ligand binding site [chemical binding]; other site
1097668022882	Domain of unknown function DUF302; Region: DUF302; pfam03625
1097668022883	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1097668022884	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1097668022885	putative DNA binding site [nucleotide binding]; other site
1097668022886	putative Zn2+ binding site [ion binding]; other site
1097668022887	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1097668022888	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097668022889	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1097668022890	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1097668022891	Walker A/P-loop; other site
1097668022892	ATP binding site [chemical binding]; other site
1097668022893	Q-loop/lid; other site
1097668022894	ABC transporter signature motif; other site
1097668022895	Walker B; other site
1097668022896	D-loop; other site
1097668022897	H-loop/switch region; other site
1097668022898	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1097668022899	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1097668022900	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1097668022901	TM-ABC transporter signature motif; other site
1097668022902	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1097668022903	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1097668022904	putative ligand binding site [chemical binding]; other site
1097668022905	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
1097668022906	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
1097668022907	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668022908	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668022909	DNA-binding site [nucleotide binding]; DNA binding site
1097668022910	RNA-binding motif; other site
1097668022911	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1097668022912	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1097668022913	dimerization interface [polypeptide binding]; other site
1097668022914	NAD binding site [chemical binding]; other site
1097668022915	ligand binding site [chemical binding]; other site
1097668022916	catalytic site [active]
1097668022917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022918	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668022919	putative substrate translocation pore; other site
1097668022920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022921	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1097668022922	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668022923	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1097668022924	active site
1097668022925	catalytic residues [active]
1097668022926	metal binding site [ion binding]; metal-binding site
1097668022927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022928	D-galactonate transporter; Region: 2A0114; TIGR00893
1097668022929	putative substrate translocation pore; other site
1097668022930	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668022931	enoyl-CoA hydratase; Provisional; Region: PRK07657
1097668022932	substrate binding site [chemical binding]; other site
1097668022933	oxyanion hole (OAH) forming residues; other site
1097668022934	trimer interface [polypeptide binding]; other site
1097668022935	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668022936	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668022937	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1097668022938	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1097668022939	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1097668022940	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1097668022941	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1097668022942	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668022943	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668022944	dimerization interface [polypeptide binding]; other site
1097668022945	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1097668022946	metal coordination site [ion binding]; other site
1097668022947	NifQ; Region: NifQ; pfam04891
1097668022948	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
1097668022949	Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197
1097668022950	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
1097668022951	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668022952	E3 interaction surface; other site
1097668022953	lipoyl attachment site [posttranslational modification]; other site
1097668022954	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1097668022955	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1097668022956	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668022957	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1097668022958	benzoate transport; Region: 2A0115; TIGR00895
1097668022959	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022960	putative substrate translocation pore; other site
1097668022961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668022962	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668022963	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668022964	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
1097668022965	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668022966	substrate binding pocket [chemical binding]; other site
1097668022967	membrane-bound complex binding site; other site
1097668022968	hinge residues; other site
1097668022969	ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
1097668022970	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668022971	Walker A/P-loop; other site
1097668022972	ATP binding site [chemical binding]; other site
1097668022973	Q-loop/lid; other site
1097668022974	ABC transporter signature motif; other site
1097668022975	Walker B; other site
1097668022976	D-loop; other site
1097668022977	H-loop/switch region; other site
1097668022978	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668022979	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668022980	dimer interface [polypeptide binding]; other site
1097668022981	conserved gate region; other site
1097668022982	putative PBP binding loops; other site
1097668022983	ABC-ATPase subunit interface; other site
1097668022984	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1097668022985	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668022986	substrate binding pocket [chemical binding]; other site
1097668022987	membrane-bound complex binding site; other site
1097668022988	hinge residues; other site
1097668022989	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668022990	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668022991	dimer interface [polypeptide binding]; other site
1097668022992	conserved gate region; other site
1097668022993	putative PBP binding loops; other site
1097668022994	ABC-ATPase subunit interface; other site
1097668022995	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668022996	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668022997	Walker A/P-loop; other site
1097668022998	ATP binding site [chemical binding]; other site
1097668022999	Q-loop/lid; other site
1097668023000	ABC transporter signature motif; other site
1097668023001	Walker B; other site
1097668023002	D-loop; other site
1097668023003	H-loop/switch region; other site
1097668023004	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1097668023005	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1097668023006	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1097668023007	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1097668023008	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1097668023009	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
1097668023010	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1097668023011	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1097668023012	substrate binding pocket [chemical binding]; other site
1097668023013	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1097668023014	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1097668023015	Coenzyme A binding pocket [chemical binding]; other site
1097668023016	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1097668023017	beta-alpha-beta structure motif; other site
1097668023018	NAD binding pocket [chemical binding]; other site
1097668023019	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1097668023020	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1097668023021	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1097668023022	Na binding site [ion binding]; other site
1097668023023	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1097668023024	Sulfatase; Region: Sulfatase; cl17466
1097668023025	Sulfatase; Region: Sulfatase; cl17466
1097668023026	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1097668023027	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1097668023028	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
1097668023029	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668023030	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668023031	metal binding site [ion binding]; metal-binding site
1097668023032	active site
1097668023033	I-site; other site
1097668023034	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1097668023035	hydrophobic ligand binding site; other site
1097668023036	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1097668023037	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421
1097668023038	active site
1097668023039	salicylate hydroxylase; Provisional; Region: PRK08163
1097668023040	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668023041	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1097668023042	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1097668023043	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1097668023044	N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015
1097668023045	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668023046	catalytic triad [active]
1097668023047	substrate binding site [chemical binding]; other site
1097668023048	domain interfaces; other site
1097668023049	conserved cis-peptide bond; other site
1097668023050	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
1097668023051	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1097668023052	NAD(P) binding site [chemical binding]; other site
1097668023053	homotetramer interface [polypeptide binding]; other site
1097668023054	homodimer interface [polypeptide binding]; other site
1097668023055	active site
1097668023056	putative acyltransferase; Provisional; Region: PRK05790
1097668023057	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1097668023058	dimer interface [polypeptide binding]; other site
1097668023059	active site
1097668023060	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097668023061	Cytochrome P450; Region: p450; cl12078
1097668023062	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1097668023063	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1097668023064	FMN-binding pocket [chemical binding]; other site
1097668023065	flavin binding motif; other site
1097668023066	phosphate binding motif [ion binding]; other site
1097668023067	beta-alpha-beta structure motif; other site
1097668023068	NAD binding pocket [chemical binding]; other site
1097668023069	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668023070	catalytic loop [active]
1097668023071	iron binding site [ion binding]; other site
1097668023072	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1097668023073	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097668023074	manganese transport protein MntH; Reviewed; Region: PRK00701
1097668023075	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1097668023076	Phage integrase protein; Region: DUF3701; pfam12482
1097668023077	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668023078	active site
1097668023079	DNA binding site [nucleotide binding]
1097668023080	Int/Topo IB signature motif; other site
1097668023081	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1097668023082	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668023083	P-loop; other site
1097668023084	Magnesium ion binding site [ion binding]; other site
1097668023085	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668023086	Magnesium ion binding site [ion binding]; other site
1097668023087	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1097668023088	ParB-like nuclease domain; Region: ParBc; pfam02195
1097668023089	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1097668023090	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1097668023091	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1097668023092	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1097668023093	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668023094	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097668023095	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668023096	DNA binding residues [nucleotide binding]
1097668023097	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668023098	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1097668023099	C-terminal domain interface [polypeptide binding]; other site
1097668023100	GSH binding site (G-site) [chemical binding]; other site
1097668023101	dimer interface [polypeptide binding]; other site
1097668023102	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
1097668023103	dimer interface [polypeptide binding]; other site
1097668023104	N-terminal domain interface [polypeptide binding]; other site
1097668023105	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1097668023106	classical (c) SDRs; Region: SDR_c; cd05233
1097668023107	NAD(P) binding site [chemical binding]; other site
1097668023108	active site
1097668023109	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1097668023110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668023111	Walker A motif; other site
1097668023112	ATP binding site [chemical binding]; other site
1097668023113	Walker B motif; other site
1097668023114	arginine finger; other site
1097668023115	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1097668023116	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
1097668023117	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1097668023118	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1097668023119	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1097668023120	tetramer interface [polypeptide binding]; other site
1097668023121	TPP-binding site [chemical binding]; other site
1097668023122	heterodimer interface [polypeptide binding]; other site
1097668023123	phosphorylation loop region [posttranslational modification]
1097668023124	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1097668023125	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1097668023126	alpha subunit interface [polypeptide binding]; other site
1097668023127	TPP binding site [chemical binding]; other site
1097668023128	heterodimer interface [polypeptide binding]; other site
1097668023129	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1097668023130	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1097668023131	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1097668023132	E3 interaction surface; other site
1097668023133	lipoyl attachment site [posttranslational modification]; other site
1097668023134	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1097668023135	catalytic site [active]
1097668023136	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1097668023137	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
1097668023138	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1097668023139	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1097668023140	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1097668023141	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1097668023142	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1097668023143	dimer interface [polypeptide binding]; other site
1097668023144	ADP-ribose binding site [chemical binding]; other site
1097668023145	active site
1097668023146	nudix motif; other site
1097668023147	metal binding site [ion binding]; metal-binding site
1097668023148	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
1097668023149	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1097668023150	Walker A/P-loop; other site
1097668023151	ATP binding site [chemical binding]; other site
1097668023152	Q-loop/lid; other site
1097668023153	ABC transporter signature motif; other site
1097668023154	Walker B; other site
1097668023155	D-loop; other site
1097668023156	H-loop/switch region; other site
1097668023157	TOBE domain; Region: TOBE; cl01440
1097668023158	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1097668023159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668023160	dimer interface [polypeptide binding]; other site
1097668023161	conserved gate region; other site
1097668023162	putative PBP binding loops; other site
1097668023163	ABC-ATPase subunit interface; other site
1097668023164	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1097668023165	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1097668023166	enoyl-CoA hydratase; Provisional; Region: PRK05995
1097668023167	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668023168	substrate binding site [chemical binding]; other site
1097668023169	oxyanion hole (OAH) forming residues; other site
1097668023170	trimer interface [polypeptide binding]; other site
1097668023171	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1097668023172	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1097668023173	putative C-terminal domain interface [polypeptide binding]; other site
1097668023174	putative GSH binding site (G-site) [chemical binding]; other site
1097668023175	putative dimer interface [polypeptide binding]; other site
1097668023176	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668023177	N-terminal domain interface [polypeptide binding]; other site
1097668023178	dimer interface [polypeptide binding]; other site
1097668023179	substrate binding pocket (H-site) [chemical binding]; other site
1097668023180	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
1097668023181	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1097668023182	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1097668023183	Cytochrome c; Region: Cytochrom_C; cl11414
1097668023184	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1097668023185	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
1097668023186	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1097668023187	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1097668023188	oligomeric interface; other site
1097668023189	putative active site [active]
1097668023190	homodimer interface [polypeptide binding]; other site
1097668023191	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
1097668023192	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1097668023193	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1097668023194	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1097668023195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023196	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1097668023197	dimerization interface [polypeptide binding]; other site
1097668023198	substrate binding pocket [chemical binding]; other site
1097668023199	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023200	putative substrate translocation pore; other site
1097668023201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023202	Ion channel; Region: Ion_trans_2; pfam07885
1097668023203	short chain dehydrogenase; Provisional; Region: PRK12828
1097668023204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668023205	NAD(P) binding site [chemical binding]; other site
1097668023206	active site
1097668023207	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668023208	PAS fold; Region: PAS_3; pfam08447
1097668023209	putative active site [active]
1097668023210	heme pocket [chemical binding]; other site
1097668023211	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668023212	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668023213	metal binding site [ion binding]; metal-binding site
1097668023214	active site
1097668023215	I-site; other site
1097668023216	Proteins containing SET domain [General function prediction only]; Region: COG2940
1097668023217	SET domain; Region: SET; pfam00856
1097668023218	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1097668023219	FAD binding domain; Region: FAD_binding_4; pfam01565
1097668023220	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1097668023221	Cupin domain; Region: Cupin_2; cl17218
1097668023222	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668023223	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023224	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668023225	putative dimerization interface [polypeptide binding]; other site
1097668023226	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1097668023227	active site
1097668023228	catalytic residues [active]
1097668023229	metal binding site [ion binding]; metal-binding site
1097668023230	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668023231	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668023232	benzoate transport; Region: 2A0115; TIGR00895
1097668023233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023235	putative substrate translocation pore; other site
1097668023236	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668023237	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668023238	trimer interface [polypeptide binding]; other site
1097668023239	eyelet of channel; other site
1097668023240	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1097668023241	GAF domain; Region: GAF; pfam01590
1097668023242	Phytochrome region; Region: PHY; pfam00360
1097668023243	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668023244	dimer interface [polypeptide binding]; other site
1097668023245	phosphorylation site [posttranslational modification]
1097668023246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668023247	ATP binding site [chemical binding]; other site
1097668023248	Mg2+ binding site [ion binding]; other site
1097668023249	G-X-G motif; other site
1097668023250	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1097668023251	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1097668023252	Surface antigen; Region: Bac_surface_Ag; pfam01103
1097668023253	haemagglutination activity domain; Region: Haemagg_act; smart00912
1097668023254	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668023255	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668023256	trimer interface [polypeptide binding]; other site
1097668023257	eyelet of channel; other site
1097668023258	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
1097668023259	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668023260	NAD binding site [chemical binding]; other site
1097668023261	catalytic residues [active]
1097668023262	substrate binding site [chemical binding]; other site
1097668023263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023264	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1097668023265	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668023266	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1097668023267	active site pocket [active]
1097668023268	choline dehydrogenase; Validated; Region: PRK02106
1097668023269	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668023270	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668023271	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023272	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668023273	dimerization interface [polypeptide binding]; other site
1097668023274	substrate binding pocket [chemical binding]; other site
1097668023275	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668023276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668023278	dimerization interface [polypeptide binding]; other site
1097668023279	Protein of unknown function (DUF2846); Region: DUF2846; pfam11008
1097668023280	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
1097668023281	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1097668023282	catalytic motif [active]
1097668023283	Catalytic residue [active]
1097668023284	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
1097668023285	inhibitor binding site; inhibition site
1097668023286	catalytic motif [active]
1097668023287	Catalytic residue [active]
1097668023288	Active site flap [active]
1097668023289	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1097668023290	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023291	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668023292	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668023293	putative effector binding pocket; other site
1097668023294	dimerization interface [polypeptide binding]; other site
1097668023295	benzoate transport; Region: 2A0115; TIGR00895
1097668023296	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023297	putative substrate translocation pore; other site
1097668023298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023299	Predicted membrane protein [Function unknown]; Region: COG2259
1097668023300	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1097668023301	Outer membrane efflux protein; Region: OEP; pfam02321
1097668023302	Outer membrane efflux protein; Region: OEP; pfam02321
1097668023303	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1097668023304	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1097668023305	HlyD family secretion protein; Region: HlyD_3; pfam13437
1097668023306	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
1097668023307	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
1097668023308	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023309	active site
1097668023310	phosphorylation site [posttranslational modification]
1097668023311	intermolecular recognition site; other site
1097668023312	dimerization interface [polypeptide binding]; other site
1097668023313	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668023314	DNA binding site [nucleotide binding]
1097668023315	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1097668023316	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1097668023317	dimerization interface [polypeptide binding]; other site
1097668023318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668023319	dimer interface [polypeptide binding]; other site
1097668023320	phosphorylation site [posttranslational modification]
1097668023321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668023322	ATP binding site [chemical binding]; other site
1097668023323	Mg2+ binding site [ion binding]; other site
1097668023324	G-X-G motif; other site
1097668023325	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668023326	Domain of unknown function (DUF4148); Region: DUF4148; pfam13663
1097668023327	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1097668023328	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
1097668023329	putative NAD(P) binding site [chemical binding]; other site
1097668023330	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1097668023331	dimer interface [polypeptide binding]; other site
1097668023332	FMN binding site [chemical binding]; other site
1097668023333	Spore Coat Protein U domain; Region: SCPU; pfam05229
1097668023334	Uncharacterized secreted protein [Function unknown]; Region: COG5430
1097668023335	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1097668023336	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1097668023337	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1097668023338	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1097668023339	Uncharacterized secreted protein [Function unknown]; Region: COG5430
1097668023340	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
1097668023341	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1097668023342	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668023343	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668023344	catalytic residue [active]
1097668023345	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1097668023346	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1097668023347	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
1097668023348	putative sugar binding site [chemical binding]; other site
1097668023349	catalytic residues [active]
1097668023350	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1097668023351	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1097668023352	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1097668023353	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1097668023354	Secretin and TonB N terminus short domain; Region: STN; smart00965
1097668023355	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1097668023356	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1097668023357	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1097668023358	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1097668023359	Walker A motif; other site
1097668023360	ATP binding site [chemical binding]; other site
1097668023361	Walker B motif; other site
1097668023362	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1097668023363	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668023364	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1097668023365	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1097668023366	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1097668023367	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
1097668023368	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1097668023369	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1097668023370	Glyco_18 domain; Region: Glyco_18; smart00636
1097668023371	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1097668023372	active site
1097668023373	allantoate amidohydrolase; Reviewed; Region: PRK12890
1097668023374	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1097668023375	active site
1097668023376	metal binding site [ion binding]; metal-binding site
1097668023377	dimer interface [polypeptide binding]; other site
1097668023378	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1097668023379	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1097668023380	heterodimer interface [polypeptide binding]; other site
1097668023381	active site
1097668023382	FMN binding site [chemical binding]; other site
1097668023383	homodimer interface [polypeptide binding]; other site
1097668023384	substrate binding site [chemical binding]; other site
1097668023385	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1097668023386	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1097668023387	FAD binding pocket [chemical binding]; other site
1097668023388	FAD binding motif [chemical binding]; other site
1097668023389	phosphate binding motif [ion binding]; other site
1097668023390	beta-alpha-beta structure motif; other site
1097668023391	NAD binding pocket [chemical binding]; other site
1097668023392	Iron coordination center [ion binding]; other site
1097668023393	benzoate transport; Region: 2A0115; TIGR00895
1097668023394	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023395	putative substrate translocation pore; other site
1097668023396	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668023397	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668023398	trimer interface [polypeptide binding]; other site
1097668023399	eyelet of channel; other site
1097668023400	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
1097668023401	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1097668023402	CHAP domain; Region: CHAP; cl17642
1097668023403	Transposase; Region: HTH_Tnp_1; cl17663
1097668023404	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
1097668023405	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668023406	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668023407	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668023408	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023409	putative substrate translocation pore; other site
1097668023410	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097668023411	Cytochrome P450; Region: p450; cl12078
1097668023412	short chain dehydrogenase; Provisional; Region: PRK06172
1097668023413	classical (c) SDRs; Region: SDR_c; cd05233
1097668023414	NAD(P) binding site [chemical binding]; other site
1097668023415	active site
1097668023416	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1097668023417	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1097668023418	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
1097668023419	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1097668023420	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1097668023421	Ligand binding site [chemical binding]; other site
1097668023422	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1097668023423	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023424	putative substrate translocation pore; other site
1097668023425	hypothetical protein; Provisional; Region: PRK06126
1097668023426	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1097668023427	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1097668023428	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1097668023429	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1097668023430	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
1097668023431	Cupin domain; Region: Cupin_2; pfam07883
1097668023432	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1097668023433	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1097668023434	active site
1097668023435	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1097668023436	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668023437	NAD(P) binding site [chemical binding]; other site
1097668023438	catalytic residues [active]
1097668023439	enoyl-CoA hydratase; Provisional; Region: PRK07657
1097668023440	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668023441	substrate binding site [chemical binding]; other site
1097668023442	oxyanion hole (OAH) forming residues; other site
1097668023443	trimer interface [polypeptide binding]; other site
1097668023444	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668023445	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668023446	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668023447	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668023448	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1097668023449	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1097668023450	catalytic loop [active]
1097668023451	iron binding site [ion binding]; other site
1097668023452	acyl-CoA thioesterase II; Region: tesB; TIGR00189
1097668023453	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1097668023454	active site
1097668023455	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1097668023456	catalytic triad [active]
1097668023457	dimer interface [polypeptide binding]; other site
1097668023458	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
1097668023459	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
1097668023460	acyl-activating enzyme (AAE) consensus motif; other site
1097668023461	putative AMP binding site [chemical binding]; other site
1097668023462	putative active site [active]
1097668023463	putative CoA binding site [chemical binding]; other site
1097668023464	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1097668023465	classical (c) SDRs; Region: SDR_c; cd05233
1097668023466	NAD(P) binding site [chemical binding]; other site
1097668023467	active site
1097668023468	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097668023469	Cytochrome P450; Region: p450; cl12078
1097668023470	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1097668023471	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1097668023472	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1097668023473	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1097668023474	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668023475	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668023476	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1097668023477	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023478	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1097668023479	dimerization interface [polypeptide binding]; other site
1097668023480	substrate binding pocket [chemical binding]; other site
1097668023481	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668023482	classical (c) SDRs; Region: SDR_c; cd05233
1097668023483	NAD(P) binding site [chemical binding]; other site
1097668023484	active site
1097668023485	Cupin; Region: Cupin_6; pfam12852
1097668023486	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1097668023487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668023488	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1097668023489	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1097668023490	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1097668023491	putative CoA-transferase; Provisional; Region: PRK11430
1097668023492	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668023493	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1097668023494	active site 1 [active]
1097668023495	active site 2 [active]
1097668023496	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668023497	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668023498	trimer interface [polypeptide binding]; other site
1097668023499	eyelet of channel; other site
1097668023500	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097668023501	Cytochrome P450; Region: p450; cl12078
1097668023502	classical (c) SDRs; Region: SDR_c; cd05233
1097668023503	NAD(P) binding site [chemical binding]; other site
1097668023504	active site
1097668023505	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1097668023506	Cytochrome P450; Region: p450; cl12078
1097668023507	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
1097668023508	benzoate transport; Region: 2A0115; TIGR00895
1097668023509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023510	putative substrate translocation pore; other site
1097668023511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023512	succinic semialdehyde dehydrogenase; Region: PLN02278
1097668023513	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1097668023514	tetramerization interface [polypeptide binding]; other site
1097668023515	NAD(P) binding site [chemical binding]; other site
1097668023516	catalytic residues [active]
1097668023517	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668023518	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668023519	active site
1097668023520	catalytic tetrad [active]
1097668023521	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
1097668023522	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1097668023523	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1097668023524	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1097668023525	active site
1097668023526	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1097668023527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1097668023528	dimer interface [polypeptide binding]; other site
1097668023529	conserved gate region; other site
1097668023530	putative PBP binding loops; other site
1097668023531	ABC-ATPase subunit interface; other site
1097668023532	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1097668023533	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1097668023534	Walker A/P-loop; other site
1097668023535	ATP binding site [chemical binding]; other site
1097668023536	Q-loop/lid; other site
1097668023537	ABC transporter signature motif; other site
1097668023538	Walker B; other site
1097668023539	D-loop; other site
1097668023540	H-loop/switch region; other site
1097668023541	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1097668023542	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1097668023543	membrane-bound complex binding site; other site
1097668023544	hinge residues; other site
1097668023545	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
1097668023546	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023547	active site
1097668023548	phosphorylation site [posttranslational modification]
1097668023549	intermolecular recognition site; other site
1097668023550	dimerization interface [polypeptide binding]; other site
1097668023551	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1097668023552	DNA binding site [nucleotide binding]
1097668023553	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1097668023554	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668023555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668023556	dimer interface [polypeptide binding]; other site
1097668023557	phosphorylation site [posttranslational modification]
1097668023558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668023559	ATP binding site [chemical binding]; other site
1097668023560	Mg2+ binding site [ion binding]; other site
1097668023561	G-X-G motif; other site
1097668023562	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1097668023563	active site
1097668023564	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668023565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023566	putative substrate translocation pore; other site
1097668023567	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1097668023568	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1097668023569	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1097668023570	inhibitor site; inhibition site
1097668023571	active site
1097668023572	dimer interface [polypeptide binding]; other site
1097668023573	catalytic residue [active]
1097668023574	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1097668023575	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1097668023576	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1097668023577	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1097668023578	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1097668023579	active site
1097668023580	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668023581	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668023582	DNA-binding site [nucleotide binding]; DNA binding site
1097668023583	FCD domain; Region: FCD; pfam07729
1097668023584	Protein of unknown function DUF126; Region: DUF126; pfam01989
1097668023585	substrate binding site [chemical binding]; other site
1097668023586	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
1097668023587	Protein of unknown function (DUF521); Region: DUF521; pfam04412
1097668023588	substrate binding site [chemical binding]; other site
1097668023589	ligand binding site [chemical binding]; other site
1097668023590	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668023591	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668023592	feruloyl-CoA synthase; Reviewed; Region: PRK08180
1097668023593	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
1097668023594	acyl-activating enzyme (AAE) consensus motif; other site
1097668023595	putative AMP binding site [chemical binding]; other site
1097668023596	putative active site [active]
1097668023597	putative CoA binding site [chemical binding]; other site
1097668023598	Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714
1097668023599	Helix-turn-helix domain; Region: HTH_20; pfam12840
1097668023600	putative DNA binding site [nucleotide binding]; other site
1097668023601	putative Zn2+ binding site [ion binding]; other site
1097668023602	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1097668023603	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1097668023604	dimer interface [polypeptide binding]; other site
1097668023605	active site
1097668023606	heme binding site [chemical binding]; other site
1097668023607	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1097668023608	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668023609	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668023610	tetramer interface [polypeptide binding]; other site
1097668023611	active site
1097668023612	Mg2+/Mn2+ binding site [ion binding]; other site
1097668023613	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668023614	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668023615	tetramer interface [polypeptide binding]; other site
1097668023616	active site
1097668023617	Mg2+/Mn2+ binding site [ion binding]; other site
1097668023618	benzoate transport; Region: 2A0115; TIGR00895
1097668023619	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023620	putative substrate translocation pore; other site
1097668023621	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023622	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1097668023623	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668023624	DNA-binding site [nucleotide binding]; DNA binding site
1097668023625	FCD domain; Region: FCD; pfam07729
1097668023626	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668023627	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668023628	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1097668023629	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
1097668023630	active site
1097668023631	acyl-activating enzyme (AAE) consensus motif; other site
1097668023632	putative CoA binding site [chemical binding]; other site
1097668023633	AMP binding site [chemical binding]; other site
1097668023634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023635	putative substrate translocation pore; other site
1097668023636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023637	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1097668023638	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1097668023639	DNA binding residues [nucleotide binding]
1097668023640	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1097668023641	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1097668023642	transcriptional regulator; Provisional; Region: PRK10632
1097668023643	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023644	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668023645	putative effector binding pocket; other site
1097668023646	dimerization interface [polypeptide binding]; other site
1097668023647	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1097668023648	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023649	putative substrate translocation pore; other site
1097668023650	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668023651	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023652	active site
1097668023653	phosphorylation site [posttranslational modification]
1097668023654	intermolecular recognition site; other site
1097668023655	dimerization interface [polypeptide binding]; other site
1097668023656	PAS domain S-box; Region: sensory_box; TIGR00229
1097668023657	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668023658	putative active site [active]
1097668023659	heme pocket [chemical binding]; other site
1097668023660	PAS fold; Region: PAS; pfam00989
1097668023661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668023662	putative active site [active]
1097668023663	heme pocket [chemical binding]; other site
1097668023664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668023665	dimer interface [polypeptide binding]; other site
1097668023666	phosphorylation site [posttranslational modification]
1097668023667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668023668	ATP binding site [chemical binding]; other site
1097668023669	Mg2+ binding site [ion binding]; other site
1097668023670	G-X-G motif; other site
1097668023671	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1097668023672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023673	active site
1097668023674	phosphorylation site [posttranslational modification]
1097668023675	intermolecular recognition site; other site
1097668023676	dimerization interface [polypeptide binding]; other site
1097668023677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668023678	DNA binding residues [nucleotide binding]
1097668023679	dimerization interface [polypeptide binding]; other site
1097668023680	PAS domain; Region: PAS; smart00091
1097668023681	PAS fold; Region: PAS_7; pfam12860
1097668023682	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1097668023683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1097668023684	metal binding site [ion binding]; metal-binding site
1097668023685	active site
1097668023686	I-site; other site
1097668023687	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668023688	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668023689	putative substrate translocation pore; other site
1097668023690	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668023691	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668023692	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668023693	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1097668023694	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1097668023695	trimer interface [polypeptide binding]; other site
1097668023696	active site
1097668023697	dimer interface [polypeptide binding]; other site
1097668023698	aromatic amino acid transporter; Provisional; Region: PRK10238
1097668023699	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1097668023700	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668023701	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668023702	homodimer interface [polypeptide binding]; other site
1097668023703	catalytic residue [active]
1097668023704	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
1097668023705	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
1097668023706	Trp docking motif [polypeptide binding]; other site
1097668023707	putative active site [active]
1097668023708	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097668023709	Domain of unknown function DUF; Region: DUF204; pfam02659
1097668023710	Domain of unknown function DUF; Region: DUF204; pfam02659
1097668023711	alanine racemase; Reviewed; Region: dadX; PRK03646
1097668023712	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1097668023713	active site
1097668023714	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1097668023715	substrate binding site [chemical binding]; other site
1097668023716	catalytic residues [active]
1097668023717	dimer interface [polypeptide binding]; other site
1097668023718	L-lactate permease; Region: Lactate_perm; cl00701
1097668023719	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1097668023720	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668023721	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668023722	dimer interface [polypeptide binding]; other site
1097668023723	phosphorylation site [posttranslational modification]
1097668023724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668023725	ATP binding site [chemical binding]; other site
1097668023726	Mg2+ binding site [ion binding]; other site
1097668023727	G-X-G motif; other site
1097668023728	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668023729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023730	active site
1097668023731	phosphorylation site [posttranslational modification]
1097668023732	intermolecular recognition site; other site
1097668023733	dimerization interface [polypeptide binding]; other site
1097668023734	heat shock protein HtpX; Provisional; Region: PRK05457
1097668023735	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
1097668023736	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1097668023737	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023738	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1097668023739	putative dimerization interface [polypeptide binding]; other site
1097668023740	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668023741	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668023742	trimer interface [polypeptide binding]; other site
1097668023743	eyelet of channel; other site
1097668023744	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
1097668023745	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668023746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668023747	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668023748	putative effector binding pocket; other site
1097668023749	dimerization interface [polypeptide binding]; other site
1097668023750	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1097668023751	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1097668023752	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668023753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668023754	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668023755	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668023756	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1097668023757	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668023758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668023759	Hemerythrin-like domain; Region: Hr-like; cd12108
1097668023760	Fe binding site [ion binding]; other site
1097668023761	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1097668023762	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1097668023763	ATP binding site [chemical binding]; other site
1097668023764	putative Mg++ binding site [ion binding]; other site
1097668023765	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1097668023766	nucleotide binding region [chemical binding]; other site
1097668023767	ATP-binding site [chemical binding]; other site
1097668023768	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668023769	active site
1097668023770	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1097668023771	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097668023772	NAD binding site [chemical binding]; other site
1097668023773	catalytic Zn binding site [ion binding]; other site
1097668023774	structural Zn binding site [ion binding]; other site
1097668023775	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668023776	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023777	active site
1097668023778	phosphorylation site [posttranslational modification]
1097668023779	intermolecular recognition site; other site
1097668023780	dimerization interface [polypeptide binding]; other site
1097668023781	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1097668023782	dimanganese center [ion binding]; other site
1097668023783	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1097668023784	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668023785	Cytochrome c; Region: Cytochrom_C; cl11414
1097668023786	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668023787	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668023788	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
1097668023789	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1097668023790	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865
1097668023791	Subunit I/III interface [polypeptide binding]; other site
1097668023792	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1097668023793	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1097668023794	D-pathway; other site
1097668023795	Putative ubiquinol binding site [chemical binding]; other site
1097668023796	Low-spin heme (heme b) binding site [chemical binding]; other site
1097668023797	Putative water exit pathway; other site
1097668023798	Binuclear center (heme o3/CuB) [ion binding]; other site
1097668023799	K-pathway; other site
1097668023800	Putative proton exit pathway; other site
1097668023801	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1097668023802	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1097668023803	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668023804	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1097668023805	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1097668023806	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1097668023807	putative molybdopterin cofactor binding site [chemical binding]; other site
1097668023808	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1097668023809	putative molybdopterin cofactor binding site; other site
1097668023810	Hemerythrin-like domain; Region: Hr-like; cd12108
1097668023811	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1097668023812	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1097668023813	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1097668023814	homodimer interface [polypeptide binding]; other site
1097668023815	NAD binding pocket [chemical binding]; other site
1097668023816	ATP binding pocket [chemical binding]; other site
1097668023817	Mg binding site [ion binding]; other site
1097668023818	active-site loop [active]
1097668023819	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
1097668023820	dimerization interface [polypeptide binding]; other site
1097668023821	metal binding site [ion binding]; metal-binding site
1097668023822	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1097668023823	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1097668023824	NAD binding site [chemical binding]; other site
1097668023825	catalytic Zn binding site [ion binding]; other site
1097668023826	structural Zn binding site [ion binding]; other site
1097668023827	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1097668023828	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1097668023829	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1097668023830	CsbD-like; Region: CsbD; cl17424
1097668023831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023832	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668023833	active site
1097668023834	phosphorylation site [posttranslational modification]
1097668023835	intermolecular recognition site; other site
1097668023836	dimerization interface [polypeptide binding]; other site
1097668023837	Major royal jelly protein; Region: MRJP; pfam03022
1097668023838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1097668023839	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1097668023840	short chain dehydrogenase; Provisional; Region: PRK06701
1097668023841	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1097668023842	NAD binding site [chemical binding]; other site
1097668023843	metal binding site [ion binding]; metal-binding site
1097668023844	active site
1097668023845	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668023846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668023847	dimer interface [polypeptide binding]; other site
1097668023848	phosphorylation site [posttranslational modification]
1097668023849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668023850	ATP binding site [chemical binding]; other site
1097668023851	Mg2+ binding site [ion binding]; other site
1097668023852	G-X-G motif; other site
1097668023853	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668023854	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668023855	active site
1097668023856	phosphorylation site [posttranslational modification]
1097668023857	intermolecular recognition site; other site
1097668023858	dimerization interface [polypeptide binding]; other site
1097668023859	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
1097668023860	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668023861	Walker A motif; other site
1097668023862	ATP binding site [chemical binding]; other site
1097668023863	Walker B motif; other site
1097668023864	KaiC; Region: KaiC; pfam06745
1097668023865	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668023866	Walker A motif; other site
1097668023867	ATP binding site [chemical binding]; other site
1097668023868	Walker B motif; other site
1097668023869	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1097668023870	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1097668023871	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1097668023872	nucleotide binding site [chemical binding]; other site
1097668023873	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1097668023874	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1097668023875	putative dimer interface [polypeptide binding]; other site
1097668023876	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1097668023877	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1097668023878	putative dimer interface [polypeptide binding]; other site
1097668023879	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1097668023880	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1097668023881	putative dimer interface [polypeptide binding]; other site
1097668023882	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1097668023883	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1097668023884	ring oligomerisation interface [polypeptide binding]; other site
1097668023885	ATP/Mg binding site [chemical binding]; other site
1097668023886	stacking interactions; other site
1097668023887	hinge regions; other site
1097668023888	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1097668023889	oligomerisation interface [polypeptide binding]; other site
1097668023890	mobile loop; other site
1097668023891	roof hairpin; other site
1097668023892	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1097668023893	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1097668023894	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668023895	Transposase; Region: HTH_Tnp_1; pfam01527
1097668023896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668023897	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668023898	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668023899	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668023900	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668023901	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668023902	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668023903	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1097668023904	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
1097668023905	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1097668023906	Helix-turn-helix domain; Region: HTH_38; pfam13936
1097668023907	Integrase core domain; Region: rve; pfam00665
1097668023908	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668023909	putative transposase OrfB; Reviewed; Region: PHA02517
1097668023910	HTH-like domain; Region: HTH_21; pfam13276
1097668023911	Integrase core domain; Region: rve; pfam00665
1097668023912	Integrase core domain; Region: rve_3; pfam13683
1097668023913	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1097668023914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1097668023915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1097668023916	S-adenosylmethionine binding site [chemical binding]; other site
1097668023917	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1097668023918	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1097668023919	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668023920	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1097668023921	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668023922	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865
1097668023923	Subunit I/III interface [polypeptide binding]; other site
1097668023924	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1097668023925	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1097668023926	D-pathway; other site
1097668023927	Putative ubiquinol binding site [chemical binding]; other site
1097668023928	Low-spin heme (heme b) binding site [chemical binding]; other site
1097668023929	Putative water exit pathway; other site
1097668023930	Binuclear center (heme o3/CuB) [ion binding]; other site
1097668023931	K-pathway; other site
1097668023932	Putative proton exit pathway; other site
1097668023933	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1097668023934	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1097668023935	Cytochrome c; Region: Cytochrom_C; pfam00034
1097668023936	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1097668023937	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1097668023938	short chain dehydrogenase; Provisional; Region: PRK07109
1097668023939	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
1097668023940	putative NAD(P) binding site [chemical binding]; other site
1097668023941	active site
1097668023942	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1097668023943	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1097668023944	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1097668023945	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1097668023946	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
1097668023947	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1097668023948	putative active site pocket [active]
1097668023949	putative metal binding site [ion binding]; other site
1097668023950	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1097668023951	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1097668023952	PYR/PP interface [polypeptide binding]; other site
1097668023953	dimer interface [polypeptide binding]; other site
1097668023954	tetramer interface [polypeptide binding]; other site
1097668023955	TPP binding site [chemical binding]; other site
1097668023956	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1097668023957	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1097668023958	TPP-binding site [chemical binding]; other site
1097668023959	MarR family; Region: MarR_2; pfam12802
1097668023960	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668023961	putative transposase OrfB; Reviewed; Region: PHA02517
1097668023962	HTH-like domain; Region: HTH_21; pfam13276
1097668023963	Integrase core domain; Region: rve; pfam00665
1097668023964	Integrase core domain; Region: rve_3; pfam13683
1097668023965	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668023966	Transposase; Region: HTH_Tnp_1; pfam01527
1097668023967	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668023968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668023969	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668023970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668023971	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668023972	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668023973	putative transposase OrfB; Reviewed; Region: PHA02517
1097668023974	Integrase core domain; Region: rve; pfam00665
1097668023975	Integrase core domain; Region: rve_3; pfam13683
1097668023976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668023977	Transposase; Region: HTH_Tnp_1; cl17663
1097668023978	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668023979	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1097668023980	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668023981	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668023982	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668023983	Transposase; Region: HTH_Tnp_1; pfam01527
1097668023984	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1097668023985	Putative glucoamylase; Region: Glycoamylase; pfam10091
1097668023986	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
1097668023987	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
1097668023988	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
1097668023989	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1097668023990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668023991	ATP binding site [chemical binding]; other site
1097668023992	Mg2+ binding site [ion binding]; other site
1097668023993	G-X-G motif; other site
1097668023994	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1097668023995	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1097668023996	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
1097668023997	Int/Topo IB signature motif; other site
1097668023998	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
1097668023999	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
1097668024000	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097668024001	IHF dimer interface [polypeptide binding]; other site
1097668024002	IHF - DNA interface [nucleotide binding]; other site
1097668024003	Proteins containing SET domain [General function prediction only]; Region: COG2940
1097668024004	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317
1097668024005	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
1097668024006	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1097668024007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1097668024008	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1097668024009	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
1097668024010	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1097668024011	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668024012	putative active site [active]
1097668024013	heme pocket [chemical binding]; other site
1097668024014	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668024015	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1097668024016	putative active site [active]
1097668024017	heme pocket [chemical binding]; other site
1097668024018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668024019	dimer interface [polypeptide binding]; other site
1097668024020	phosphorylation site [posttranslational modification]
1097668024021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668024022	ATP binding site [chemical binding]; other site
1097668024023	Mg2+ binding site [ion binding]; other site
1097668024024	G-X-G motif; other site
1097668024025	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668024026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668024027	active site
1097668024028	phosphorylation site [posttranslational modification]
1097668024029	intermolecular recognition site; other site
1097668024030	dimerization interface [polypeptide binding]; other site
1097668024031	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668024032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668024033	active site
1097668024034	phosphorylation site [posttranslational modification]
1097668024035	intermolecular recognition site; other site
1097668024036	dimerization interface [polypeptide binding]; other site
1097668024037	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1097668024038	Integrase core domain; Region: rve; pfam00665
1097668024039	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1097668024040	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668024041	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1097668024042	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668024043	dimer interface [polypeptide binding]; other site
1097668024044	phosphorylation site [posttranslational modification]
1097668024045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668024046	ATP binding site [chemical binding]; other site
1097668024047	Mg2+ binding site [ion binding]; other site
1097668024048	G-X-G motif; other site
1097668024049	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1097668024050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668024051	phosphorylation site [posttranslational modification]
1097668024052	intermolecular recognition site; other site
1097668024053	circadian clock protein KaiC; Reviewed; Region: PRK09302
1097668024054	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668024055	Walker A motif; other site
1097668024056	ATP binding site [chemical binding]; other site
1097668024057	Walker B motif; other site
1097668024058	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
1097668024059	Walker A motif; other site
1097668024060	ATP binding site [chemical binding]; other site
1097668024061	Walker B motif; other site
1097668024062	PAS domain; Region: PAS_8; pfam13188
1097668024063	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1097668024064	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668024065	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1097668024066	putative active site [active]
1097668024067	heme pocket [chemical binding]; other site
1097668024068	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668024069	putative active site [active]
1097668024070	heme pocket [chemical binding]; other site
1097668024071	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1097668024072	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1097668024073	DNA binding residues [nucleotide binding]
1097668024074	dimerization interface [polypeptide binding]; other site
1097668024075	Fic/DOC family; Region: Fic; pfam02661
1097668024076	OpgC protein; Region: OpgC_C; cl17858
1097668024077	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1097668024078	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
1097668024079	putative active site [active]
1097668024080	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1097668024081	putative transposase OrfB; Reviewed; Region: PHA02517
1097668024082	Integrase core domain; Region: rve; pfam00665
1097668024083	Integrase core domain; Region: rve_3; pfam13683
1097668024084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668024085	Transposase; Region: HTH_Tnp_1; cl17663
1097668024086	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1097668024087	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1097668024088	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1097668024089	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1097668024090	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1097668024091	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1097668024092	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668024093	DNA binding residues [nucleotide binding]
1097668024094	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668024095	DNA-binding site [nucleotide binding]; DNA binding site
1097668024096	RNA-binding motif; other site
1097668024097	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668024098	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097668024099	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668024100	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1097668024101	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668024102	DNA-binding site [nucleotide binding]; DNA binding site
1097668024103	RNA-binding motif; other site
1097668024104	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097668024105	transposase; Provisional; Region: PRK06526
1097668024106	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668024107	Walker A motif; other site
1097668024108	ATP binding site [chemical binding]; other site
1097668024109	Walker B motif; other site
1097668024110	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1097668024111	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
1097668024112	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
1097668024113	Int/Topo IB signature motif; other site
1097668024114	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1097668024115	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668024116	active site
1097668024117	DNA binding site [nucleotide binding]
1097668024118	Int/Topo IB signature motif; other site
1097668024119	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1097668024120	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
1097668024121	Int/Topo IB signature motif; other site
1097668024122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1097668024123	Integrase core domain; Region: rve; pfam00665
1097668024124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1097668024125	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1097668024126	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1097668024127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1097668024128	PAS domain; Region: PAS_9; pfam13426
1097668024129	putative active site [active]
1097668024130	heme pocket [chemical binding]; other site
1097668024131	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668024132	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668024133	dimer interface [polypeptide binding]; other site
1097668024134	phosphorylation site [posttranslational modification]
1097668024135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668024136	ATP binding site [chemical binding]; other site
1097668024137	Mg2+ binding site [ion binding]; other site
1097668024138	G-X-G motif; other site
1097668024139	Response regulator receiver domain; Region: Response_reg; pfam00072
1097668024140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668024141	active site
1097668024142	phosphorylation site [posttranslational modification]
1097668024143	intermolecular recognition site; other site
1097668024144	dimerization interface [polypeptide binding]; other site
1097668024145	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1097668024146	DNA binding residues [nucleotide binding]
1097668024147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668024148	Transposase; Region: HTH_Tnp_1; cl17663
1097668024149	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
1097668024150	HTH-like domain; Region: HTH_21; pfam13276
1097668024151	Integrase core domain; Region: rve; pfam00665
1097668024152	Integrase core domain; Region: rve_3; pfam13683
1097668024153	LysR family transcriptional regulator; Provisional; Region: PRK14997
1097668024154	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024155	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1097668024156	putative effector binding pocket; other site
1097668024157	putative dimerization interface [polypeptide binding]; other site
1097668024158	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668024159	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1097668024160	catalytic triad [active]
1097668024161	dimer interface [polypeptide binding]; other site
1097668024162	conserved cis-peptide bond; other site
1097668024163	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1097668024164	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1097668024165	trimer interface [polypeptide binding]; other site
1097668024166	eyelet of channel; other site
1097668024167	Pirin-related protein [General function prediction only]; Region: COG1741
1097668024168	Pirin; Region: Pirin; pfam02678
1097668024169	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1097668024170	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1097668024171	DNA binding site [nucleotide binding]
1097668024172	active site
1097668024173	Int/Topo IB signature motif; other site
1097668024174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668024175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024176	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
1097668024177	putative effector binding pocket; other site
1097668024178	putative dimerization interface [polypeptide binding]; other site
1097668024179	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1097668024180	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1097668024181	C-terminal domain interface [polypeptide binding]; other site
1097668024182	GSH binding site (G-site) [chemical binding]; other site
1097668024183	dimer interface [polypeptide binding]; other site
1097668024184	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1097668024185	N-terminal domain interface [polypeptide binding]; other site
1097668024186	dimer interface [polypeptide binding]; other site
1097668024187	substrate binding pocket (H-site) [chemical binding]; other site
1097668024188	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668024189	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668024190	putative substrate translocation pore; other site
1097668024191	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1097668024192	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668024193	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1097668024194	putative transposase OrfB; Reviewed; Region: PHA02517
1097668024195	Integrase core domain; Region: rve; pfam00665
1097668024196	Integrase core domain; Region: rve_3; pfam13683
1097668024197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1097668024198	Transposase; Region: HTH_Tnp_1; cl17663
1097668024199	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1097668024200	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668024201	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1097668024202	RES domain; Region: RES; pfam08808
1097668024203	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1097668024204	IHF dimer interface [polypeptide binding]; other site
1097668024205	IHF - DNA interface [nucleotide binding]; other site
1097668024206	TrbC/VIRB2 family; Region: TrbC; pfam04956
1097668024207	type IV secretion system ATPase VirB4; Provisional; Region: PRK13898
1097668024208	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1097668024209	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1097668024210	Type IV secretion system proteins; Region: T4SS; pfam07996
1097668024211	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1097668024212	VirB8 protein; Region: VirB8; pfam04335
1097668024213	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1097668024214	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1097668024215	VirB7 interaction site; other site
1097668024216	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1097668024217	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1097668024218	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1097668024219	Walker A motif; other site
1097668024220	hexamer interface [polypeptide binding]; other site
1097668024221	ATP binding site [chemical binding]; other site
1097668024222	Walker B motif; other site
1097668024223	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1097668024224	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1097668024225	catalytic residue [active]
1097668024226	RNA polymerase I-specific transcription-initiation factor; Region: Rrn6; pfam10214
1097668024227	TrwC relaxase; Region: TrwC; pfam08751
1097668024228	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
1097668024229	AAA domain; Region: AAA_30; pfam13604
1097668024230	Family description; Region: UvrD_C_2; pfam13538
1097668024231	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
1097668024232	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1097668024233	Walker A motif; other site
1097668024234	ATP binding site [chemical binding]; other site
1097668024235	Walker B motif; other site
1097668024236	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1097668024237	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1097668024238	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1097668024239	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668024240	P-loop; other site
1097668024241	Magnesium ion binding site [ion binding]; other site
1097668024242	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1097668024243	Magnesium ion binding site [ion binding]; other site
1097668024244	ParB-like nuclease domain; Region: ParB; smart00470
1097668024245	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1097668024246	Phage integrase protein; Region: DUF3701; pfam12482
1097668024247	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1097668024248	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668024249	active site
1097668024250	Int/Topo IB signature motif; other site
1097668024251	catalytic residues [active]
1097668024252	DNA binding site [nucleotide binding]
1097668024253	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1097668024254	Divergent AAA domain; Region: AAA_4; pfam04326
1097668024255	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1097668024256	enolase; Provisional; Region: eno; PRK00077
1097668024257	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1097668024258	dimer interface [polypeptide binding]; other site
1097668024259	metal binding site [ion binding]; metal-binding site
1097668024260	substrate binding pocket [chemical binding]; other site
1097668024261	pyruvate kinase; Provisional; Region: PRK06247
1097668024262	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1097668024263	active site
1097668024264	domain interfaces; other site
1097668024265	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1097668024266	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1097668024267	MOFRL family; Region: MOFRL; pfam05161
1097668024268	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1097668024269	tartrate dehydrogenase; Region: TTC; TIGR02089
1097668024270	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
1097668024271	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
1097668024272	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
1097668024273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668024274	putative substrate translocation pore; other site
1097668024275	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024276	transcriptional activator TtdR; Provisional; Region: PRK09801
1097668024277	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
1097668024278	putative effector binding pocket; other site
1097668024279	putative dimerization interface [polypeptide binding]; other site
1097668024280	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1097668024281	Helix-turn-helix domain; Region: HTH_38; pfam13936
1097668024282	Homeodomain-like domain; Region: HTH_32; pfam13565
1097668024283	Integrase core domain; Region: rve; pfam00665
1097668024284	Integrase core domain; Region: rve; pfam00665
1097668024285	transposase; Validated; Region: PRK08181
1097668024286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1097668024287	Walker A motif; other site
1097668024288	ATP binding site [chemical binding]; other site
1097668024289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668024290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1097668024291	dimer interface [polypeptide binding]; other site
1097668024292	phosphorylation site [posttranslational modification]
1097668024293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668024294	ATP binding site [chemical binding]; other site
1097668024295	Mg2+ binding site [ion binding]; other site
1097668024296	G-X-G motif; other site
1097668024297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1097668024298	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668024299	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1097668024300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1097668024301	active site
1097668024302	intermolecular recognition site; other site
1097668024303	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1097668024304	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024305	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024306	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024307	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024308	CHAT domain; Region: CHAT; pfam12770
1097668024309	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
1097668024310	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1097668024311	Integrase core domain; Region: rve; pfam00665
1097668024312	Integrase core domain; Region: rve_3; pfam13683
1097668024313	Zeta toxin; Region: Zeta_toxin; pfam06414
1097668024314	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1097668024315	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1097668024316	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1097668024317	Ferritin-like domain; Region: Ferritin_2; pfam13668
1097668024318	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1097668024319	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024320	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024321	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024322	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1097668024323	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
1097668024324	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1097668024325	putative active site [active]
1097668024326	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
1097668024327	active site flap/lid [active]
1097668024328	nucleophilic elbow; other site
1097668024329	catalytic triad [active]
1097668024330	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
1097668024331	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1097668024332	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1097668024333	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1097668024334	hopanoid C-3 methylase HpnR; Region: HpnR_B12_rSAM; TIGR04367
1097668024335	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1097668024336	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1097668024337	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1097668024338	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1097668024339	MULE transposase domain; Region: MULE; pfam10551
1097668024340	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1097668024341	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668024342	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1097668024343	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1097668024344	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1097668024345	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1097668024346	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1097668024347	DNA-binding site [nucleotide binding]; DNA binding site
1097668024348	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1097668024349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1097668024350	homodimer interface [polypeptide binding]; other site
1097668024351	catalytic residue [active]
1097668024352	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1097668024353	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1097668024354	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1097668024355	Isochorismatase family; Region: Isochorismatase; pfam00857
1097668024356	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1097668024357	catalytic triad [active]
1097668024358	conserved cis-peptide bond; other site
1097668024359	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1097668024360	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1097668024361	conserved cys residue [active]
1097668024362	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668024363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1097668024364	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
1097668024365	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1097668024366	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
1097668024367	Int/Topo IB signature motif; other site
1097668024368	Putative transposase; Region: Y2_Tnp; pfam04986
1097668024369	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1097668024370	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1097668024371	active site
1097668024372	NAD binding site [chemical binding]; other site
1097668024373	metal binding site [ion binding]; metal-binding site
1097668024374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668024375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024376	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668024377	dimerization interface [polypeptide binding]; other site
1097668024378	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1097668024379	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1097668024380	NAD(P) binding site [chemical binding]; other site
1097668024381	catalytic residues [active]
1097668024382	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cl00540
1097668024383	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1097668024384	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1097668024385	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1097668024386	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1097668024387	NAD(P) binding site [chemical binding]; other site
1097668024388	active site
1097668024389	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1097668024390	substrate binding site [chemical binding]; other site
1097668024391	oxyanion hole (OAH) forming residues; other site
1097668024392	trimer interface [polypeptide binding]; other site
1097668024393	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668024394	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
1097668024395	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
1097668024396	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
1097668024397	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1097668024398	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1097668024399	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1097668024400	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024401	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1097668024402	dimerization interface [polypeptide binding]; other site
1097668024403	substrate binding pocket [chemical binding]; other site
1097668024404	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1097668024405	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1097668024406	active site
1097668024407	catalytic tetrad [active]
1097668024408	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1097668024409	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024410	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
1097668024411	putative dimerization interface [polypeptide binding]; other site
1097668024412	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668024413	putative substrate translocation pore; other site
1097668024414	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
1097668024415	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
1097668024416	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1097668024417	active site
1097668024418	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1097668024419	dimer interface [polypeptide binding]; other site
1097668024420	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1097668024421	MULE transposase domain; Region: MULE; pfam10551
1097668024422	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1097668024423	FMN binding site [chemical binding]; other site
1097668024424	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1097668024425	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1097668024426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1097668024427	metabolite-proton symporter; Region: 2A0106; TIGR00883
1097668024428	putative substrate translocation pore; other site
1097668024429	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668024430	dimerization interface [polypeptide binding]; other site
1097668024431	transcriptional regulator; Provisional; Region: PRK10632
1097668024432	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024433	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1097668024434	putative effector binding pocket; other site
1097668024435	dimerization interface [polypeptide binding]; other site
1097668024436	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1097668024437	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1097668024438	tetramer interface [polypeptide binding]; other site
1097668024439	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1097668024440	active site
1097668024441	Mg2+/Mn2+ binding site [ion binding]; other site
1097668024442	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1097668024443	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1097668024444	substrate binding site [chemical binding]; other site
1097668024445	ligand binding site [chemical binding]; other site
1097668024446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1097668024447	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1097668024448	dimerization interface [polypeptide binding]; other site
1097668024449	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1097668024450	Helix-turn-helix domain; Region: HTH_28; pfam13518
1097668024451	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
1097668024452	Winged helix-turn helix; Region: HTH_33; pfam13592
1097668024453	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1097668024454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1097668024455	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1097668024456	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1097668024457	putative active site [active]
1097668024458	putative PHP Thumb interface [polypeptide binding]; other site
1097668024459	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1097668024460	generic binding surface II; other site
1097668024461	generic binding surface I; other site
1097668024462	DNA Polymerase Y-family; Region: PolY_like; cd03468
1097668024463	active site
1097668024464	DNA binding site [nucleotide binding]
1097668024465	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1097668024466	Uncharacterized conserved protein [Function unknown]; Region: COG4544
1097668024467	Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247
1097668024468	Flagellar transcriptional activator (FlhC); Region: FlhC; cl05036
1097668024469	AAA domain; Region: AAA_30; pfam13604
1097668024470	Family description; Region: UvrD_C_2; pfam13538
1097668024471	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1097668024472	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1097668024473	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1097668024474	Helix-turn-helix domain; Region: HTH_38; pfam13936
1097668024475	Homeodomain-like domain; Region: HTH_32; pfam13565
1097668024476	Integrase core domain; Region: rve; pfam00665
1097668024477	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
1097668024478	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1097668024479	putative membrane protein, TIGR04086 family; Region: TIGR04086_membr
1097668024480	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
1097668024481	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1097668024482	dimanganese center [ion binding]; other site
1097668024483	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
1097668024484	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1097668024485	homotetramer interface [polypeptide binding]; other site
1097668024486	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1097668024487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1097668024488	ATP binding site [chemical binding]; other site
1097668024489	Mg2+ binding site [ion binding]; other site
1097668024490	G-X-G motif; other site
1097668024491	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1097668024492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
1097668024493	Integrase core domain; Region: rve; pfam00665
1097668024494	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1097668024495	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1097668024496	catalytic residues [active]
1097668024497	Recombinase; Region: Recombinase; pfam07508
1097668024498	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1097668024499	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1097668024500	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1097668024501	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1097668024502	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1097668024503	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1097668024504	DNA-binding site [nucleotide binding]; DNA binding site
1097668024505	RNA-binding motif; other site
1097668024506	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1097668024507	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1097668024508	active site
1097668024509	Int/Topo IB signature motif; other site
1097668024510	catalytic residues [active]
1097668024511	DNA binding site [nucleotide binding]
1097668024512	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
1097668024513	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1097668024514	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1097668024515	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1097668024516	Di-iron ligands [ion binding]; other site
1097668024517	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505