-- dump date 20140619_012828 -- class Genbank::misc_feature -- table misc_feature_note -- id note 331271000001 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 331271000002 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 331271000003 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 331271000004 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 331271000005 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 331271000006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271000007 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331271000008 IHF dimer interface [polypeptide binding]; other site 331271000009 IHF - DNA interface [nucleotide binding]; other site 331271000010 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 331271000011 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 331271000012 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 331271000013 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 331271000014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271000015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271000016 catalytic residue [active] 331271000017 type II secretion system protein D; Region: type_II_gspD; TIGR02517 331271000018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331271000019 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331271000020 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331271000021 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 331271000022 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 331271000023 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 331271000024 type II secretion system protein E; Region: type_II_gspE; TIGR02533 331271000025 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 331271000026 Walker A motif; other site 331271000027 ATP binding site [chemical binding]; other site 331271000028 Walker B motif; other site 331271000029 type II secretion system protein F; Region: GspF; TIGR02120 331271000030 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271000031 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271000032 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 331271000033 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 331271000034 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 331271000035 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 331271000036 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 331271000037 Type II transport protein GspH; Region: GspH; pfam12019 331271000038 type II secretion system protein I; Region: gspI; TIGR01707 331271000039 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 331271000040 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 331271000041 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 331271000042 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 331271000043 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 331271000044 GspL periplasmic domain; Region: GspL_C; pfam12693 331271000045 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 331271000046 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 331271000047 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271000048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271000049 MarR family; Region: MarR_2; cl17246 331271000050 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271000051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271000052 putative substrate translocation pore; other site 331271000053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271000054 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 331271000055 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 331271000056 putative active site [active] 331271000057 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271000058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271000059 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 331271000060 putative dimerization interface [polypeptide binding]; other site 331271000061 LrgA family; Region: LrgA; pfam03788 331271000062 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 331271000063 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 331271000064 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 331271000065 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 331271000066 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 331271000067 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 331271000068 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 331271000069 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 331271000070 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 331271000071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 331271000072 NMT1/THI5 like; Region: NMT1; pfam09084 331271000073 membrane-bound complex binding site; other site 331271000074 hinge residues; other site 331271000075 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271000076 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271000077 Walker A/P-loop; other site 331271000078 ATP binding site [chemical binding]; other site 331271000079 Q-loop/lid; other site 331271000080 ABC transporter signature motif; other site 331271000081 Walker B; other site 331271000082 D-loop; other site 331271000083 H-loop/switch region; other site 331271000084 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271000085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271000086 dimer interface [polypeptide binding]; other site 331271000087 conserved gate region; other site 331271000088 putative PBP binding loops; other site 331271000089 ABC-ATPase subunit interface; other site 331271000090 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 331271000091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271000092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271000093 dimer interface [polypeptide binding]; other site 331271000094 phosphorylation site [posttranslational modification] 331271000095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271000096 ATP binding site [chemical binding]; other site 331271000097 Mg2+ binding site [ion binding]; other site 331271000098 G-X-G motif; other site 331271000099 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 331271000100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271000101 active site 331271000102 phosphorylation site [posttranslational modification] 331271000103 intermolecular recognition site; other site 331271000104 dimerization interface [polypeptide binding]; other site 331271000105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271000106 DNA binding site [nucleotide binding] 331271000107 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271000108 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271000109 trimer interface [polypeptide binding]; other site 331271000110 eyelet of channel; other site 331271000111 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 331271000112 DNA methylase; Region: N6_N4_Mtase; pfam01555 331271000113 DNA methylase; Region: N6_N4_Mtase; cl17433 331271000114 Restriction endonuclease [Defense mechanisms]; Region: COG3587 331271000115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331271000116 ATP binding site [chemical binding]; other site 331271000117 putative Mg++ binding site [ion binding]; other site 331271000118 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 331271000119 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 331271000120 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 331271000121 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 331271000122 Uncharacterized conserved protein [Function unknown]; Region: COG2128 331271000123 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 331271000124 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 331271000125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271000126 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 331271000127 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 331271000128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271000129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271000130 DNA binding residues [nucleotide binding] 331271000131 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 331271000132 putative heme binding pocket [chemical binding]; other site 331271000133 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 331271000134 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 331271000135 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 331271000136 putative [4Fe-4S] binding site [ion binding]; other site 331271000137 putative molybdopterin cofactor binding site [chemical binding]; other site 331271000138 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 331271000139 putative molybdopterin cofactor binding site; other site 331271000140 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 331271000141 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 331271000142 acyl-activating enzyme (AAE) consensus motif; other site 331271000143 putative AMP binding site [chemical binding]; other site 331271000144 putative active site [active] 331271000145 putative CoA binding site [chemical binding]; other site 331271000146 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271000147 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271000148 trimer interface [polypeptide binding]; other site 331271000149 eyelet of channel; other site 331271000150 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 331271000151 diiron binding motif [ion binding]; other site 331271000152 cell division protein MraZ; Reviewed; Region: PRK00326 331271000153 MraZ protein; Region: MraZ; pfam02381 331271000154 MraZ protein; Region: MraZ; pfam02381 331271000155 MraW methylase family; Region: Methyltransf_5; cl17771 331271000156 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 331271000157 Cell division protein FtsL; Region: FtsL; cl11433 331271000158 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 331271000159 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331271000160 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331271000161 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 331271000162 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331271000163 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331271000164 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 331271000165 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331271000166 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331271000167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331271000168 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 331271000169 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 331271000170 Mg++ binding site [ion binding]; other site 331271000171 putative catalytic motif [active] 331271000172 putative substrate binding site [chemical binding]; other site 331271000173 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 331271000174 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331271000175 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331271000176 cell division protein FtsW; Region: ftsW; TIGR02614 331271000177 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 331271000178 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 331271000179 active site 331271000180 homodimer interface [polypeptide binding]; other site 331271000181 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 331271000182 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331271000183 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331271000184 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331271000185 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 331271000186 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 331271000187 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331271000188 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 331271000189 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 331271000190 Cell division protein FtsQ; Region: FtsQ; pfam03799 331271000191 cell division protein FtsA; Region: ftsA; TIGR01174 331271000192 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 331271000193 nucleotide binding site [chemical binding]; other site 331271000194 Cell division protein FtsA; Region: FtsA; pfam14450 331271000195 cell division protein FtsZ; Validated; Region: PRK09330 331271000196 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 331271000197 nucleotide binding site [chemical binding]; other site 331271000198 SulA interaction site; other site 331271000199 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 331271000200 catalytic triad [active] 331271000201 dimer interface [polypeptide binding]; other site 331271000202 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 331271000203 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 331271000204 Protein of unknown function (DUF721); Region: DUF721; pfam05258 331271000205 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 331271000206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 331271000207 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 331271000208 SEC-C motif; Region: SEC-C; pfam02810 331271000209 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 331271000210 heterotetramer interface [polypeptide binding]; other site 331271000211 active site pocket [active] 331271000212 cleavage site 331271000213 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 331271000214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271000215 Walker A motif; other site 331271000216 ATP binding site [chemical binding]; other site 331271000217 Walker B motif; other site 331271000218 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 331271000219 active site 331271000220 8-oxo-dGMP binding site [chemical binding]; other site 331271000221 nudix motif; other site 331271000222 metal binding site [ion binding]; metal-binding site 331271000223 Domain of unknown function (DUF329); Region: DUF329; pfam03884 331271000224 hypothetical protein; Provisional; Region: PRK05287 331271000225 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 331271000226 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 331271000227 CoA-binding site [chemical binding]; other site 331271000228 ATP-binding [chemical binding]; other site 331271000229 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 331271000230 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 331271000231 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 331271000232 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271000233 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271000234 Type II/IV secretion system protein; Region: T2SE; pfam00437 331271000235 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 331271000236 Walker A motif; other site 331271000237 ATP binding site [chemical binding]; other site 331271000238 Walker B motif; other site 331271000239 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 331271000240 Domain of unknown function DUF21; Region: DUF21; pfam01595 331271000241 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331271000242 Transporter associated domain; Region: CorC_HlyC; smart01091 331271000243 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 331271000244 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 331271000245 substrate binding pocket [chemical binding]; other site 331271000246 chain length determination region; other site 331271000247 substrate-Mg2+ binding site; other site 331271000248 catalytic residues [active] 331271000249 aspartate-rich region 1; other site 331271000250 active site lid residues [active] 331271000251 aspartate-rich region 2; other site 331271000252 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 331271000253 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 331271000254 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 331271000255 GTPase CgtA; Reviewed; Region: obgE; PRK12299 331271000256 GTP1/OBG; Region: GTP1_OBG; pfam01018 331271000257 Obg GTPase; Region: Obg; cd01898 331271000258 G1 box; other site 331271000259 GTP/Mg2+ binding site [chemical binding]; other site 331271000260 Switch I region; other site 331271000261 G2 box; other site 331271000262 G3 box; other site 331271000263 Switch II region; other site 331271000264 G4 box; other site 331271000265 G5 box; other site 331271000266 gamma-glutamyl kinase; Provisional; Region: PRK05429 331271000267 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 331271000268 nucleotide binding site [chemical binding]; other site 331271000269 homotetrameric interface [polypeptide binding]; other site 331271000270 putative phosphate binding site [ion binding]; other site 331271000271 putative allosteric binding site; other site 331271000272 PUA domain; Region: PUA; pfam01472 331271000273 CNP1-like family; Region: CNP1; pfam08750 331271000274 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 331271000275 putative active site [active] 331271000276 Ap4A binding site [chemical binding]; other site 331271000277 nudix motif; other site 331271000278 putative metal binding site [ion binding]; other site 331271000279 prolyl-tRNA synthetase; Provisional; Region: PRK09194 331271000280 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 331271000281 dimer interface [polypeptide binding]; other site 331271000282 motif 1; other site 331271000283 active site 331271000284 motif 2; other site 331271000285 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 331271000286 putative deacylase active site [active] 331271000287 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 331271000288 active site 331271000289 motif 3; other site 331271000290 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 331271000291 anticodon binding site; other site 331271000292 MarC family integral membrane protein; Region: MarC; cl00919 331271000293 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271000294 active site 331271000295 signal recognition particle protein; Provisional; Region: PRK10867 331271000296 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 331271000297 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 331271000298 P loop; other site 331271000299 GTP binding site [chemical binding]; other site 331271000300 Signal peptide binding domain; Region: SRP_SPB; pfam02978 331271000301 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 331271000302 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 331271000303 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 331271000304 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 331271000305 amidase catalytic site [active] 331271000306 Zn binding residues [ion binding]; other site 331271000307 substrate binding site [chemical binding]; other site 331271000308 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 331271000309 ATP cone domain; Region: ATP-cone; pfam03477 331271000310 Class I ribonucleotide reductase; Region: RNR_I; cd01679 331271000311 active site 331271000312 dimer interface [polypeptide binding]; other site 331271000313 catalytic residues [active] 331271000314 effector binding site; other site 331271000315 R2 peptide binding site; other site 331271000316 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 331271000317 dimer interface [polypeptide binding]; other site 331271000318 putative radical transfer pathway; other site 331271000319 diiron center [ion binding]; other site 331271000320 tyrosyl radical; other site 331271000321 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 331271000322 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271000323 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 331271000324 substrate binding site [chemical binding]; other site 331271000325 ATP binding site [chemical binding]; other site 331271000326 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 331271000327 dimer interface [polypeptide binding]; other site 331271000328 catalytic triad [active] 331271000329 peroxidatic and resolving cysteines [active] 331271000330 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 331271000331 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 331271000332 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 331271000333 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 331271000334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271000335 S-adenosylmethionine binding site [chemical binding]; other site 331271000336 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 331271000337 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331271000338 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 331271000339 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 331271000340 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 331271000341 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331271000342 carboxyltransferase (CT) interaction site; other site 331271000343 biotinylation site [posttranslational modification]; other site 331271000344 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 331271000345 Dehydroquinase class II; Region: DHquinase_II; pfam01220 331271000346 active site 331271000347 trimer interface [polypeptide binding]; other site 331271000348 dimer interface [polypeptide binding]; other site 331271000349 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 331271000350 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271000351 catalytic residues [active] 331271000352 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271000353 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271000354 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 331271000355 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331271000356 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331271000357 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331271000358 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 331271000359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271000360 Exoribonuclease R [Transcription]; Region: VacB; COG0557 331271000361 RNB domain; Region: RNB; pfam00773 331271000362 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 331271000363 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 331271000364 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 331271000365 shikimate binding site; other site 331271000366 NAD(P) binding site [chemical binding]; other site 331271000367 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 331271000368 Transglycosylase; Region: Transgly; cl17702 331271000369 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 331271000370 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 331271000371 EF-hand domain pair; Region: EF_hand_5; pfam13499 331271000372 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271000373 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271000374 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271000375 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 331271000376 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 331271000377 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 331271000378 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 331271000379 active site 331271000380 intersubunit interface [polypeptide binding]; other site 331271000381 catalytic residue [active] 331271000382 short chain dehydrogenase; Provisional; Region: PRK07063 331271000383 classical (c) SDRs; Region: SDR_c; cd05233 331271000384 NAD(P) binding site [chemical binding]; other site 331271000385 active site 331271000386 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 331271000387 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 331271000388 ligand binding site [chemical binding]; other site 331271000389 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 331271000390 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271000391 Walker A/P-loop; other site 331271000392 ATP binding site [chemical binding]; other site 331271000393 Q-loop/lid; other site 331271000394 ABC transporter signature motif; other site 331271000395 Walker B; other site 331271000396 D-loop; other site 331271000397 H-loop/switch region; other site 331271000398 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271000399 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271000400 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271000401 TM-ABC transporter signature motif; other site 331271000402 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 331271000403 classical (c) SDRs; Region: SDR_c; cd05233 331271000404 NAD(P) binding site [chemical binding]; other site 331271000405 active site 331271000406 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 331271000407 active site 331271000408 catalytic residues [active] 331271000409 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 331271000410 active site 331271000411 dimer interface [polypeptide binding]; other site 331271000412 Competence-damaged protein; Region: CinA; pfam02464 331271000413 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 331271000414 tetramer interfaces [polypeptide binding]; other site 331271000415 binuclear metal-binding site [ion binding]; other site 331271000416 thiamine monophosphate kinase; Provisional; Region: PRK05731 331271000417 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 331271000418 ATP binding site [chemical binding]; other site 331271000419 dimerization interface [polypeptide binding]; other site 331271000420 malic enzyme; Reviewed; Region: PRK12862 331271000421 Malic enzyme, N-terminal domain; Region: malic; pfam00390 331271000422 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 331271000423 putative NAD(P) binding site [chemical binding]; other site 331271000424 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 331271000425 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 331271000426 active site 331271000427 barstar interaction site; other site 331271000428 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 331271000429 putative RNAase interaction site [polypeptide binding]; other site 331271000430 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 331271000431 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 331271000432 putative dimer interface [polypeptide binding]; other site 331271000433 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271000434 spermidine synthase; Provisional; Region: PRK00811 331271000435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271000436 transketolase; Reviewed; Region: PRK12753 331271000437 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331271000438 TPP-binding site [chemical binding]; other site 331271000439 dimer interface [polypeptide binding]; other site 331271000440 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331271000441 PYR/PP interface [polypeptide binding]; other site 331271000442 dimer interface [polypeptide binding]; other site 331271000443 TPP binding site [chemical binding]; other site 331271000444 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331271000445 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 331271000446 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 331271000447 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 331271000448 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 331271000449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271000450 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 331271000451 dimerization interface [polypeptide binding]; other site 331271000452 substrate binding pocket [chemical binding]; other site 331271000453 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 331271000454 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 331271000455 NADP binding site [chemical binding]; other site 331271000456 homodimer interface [polypeptide binding]; other site 331271000457 active site 331271000458 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 331271000459 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 331271000460 putative NAD(P) binding site [chemical binding]; other site 331271000461 catalytic Zn binding site [ion binding]; other site 331271000462 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271000463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271000464 putative substrate translocation pore; other site 331271000465 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 331271000466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271000467 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 331271000468 dimerization interface [polypeptide binding]; other site 331271000469 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271000470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271000471 DNA-binding site [nucleotide binding]; DNA binding site 331271000472 FCD domain; Region: FCD; pfam07729 331271000473 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 331271000474 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271000475 allantoicase; Provisional; Region: PRK13257 331271000476 Allantoicase repeat; Region: Allantoicase; pfam03561 331271000477 Allantoicase repeat; Region: Allantoicase; pfam03561 331271000478 ureidoglycolate hydrolase; Provisional; Region: PRK13395 331271000479 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 331271000480 ferric uptake regulator; Provisional; Region: fur; PRK09462 331271000481 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331271000482 metal binding site 2 [ion binding]; metal-binding site 331271000483 putative DNA binding helix; other site 331271000484 metal binding site 1 [ion binding]; metal-binding site 331271000485 dimer interface [polypeptide binding]; other site 331271000486 structural Zn2+ binding site [ion binding]; other site 331271000487 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 331271000488 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 331271000489 dihydrodipicolinate reductase; Provisional; Region: PRK00048 331271000490 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 331271000491 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 331271000492 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 331271000493 TolR protein; Region: tolR; TIGR02801 331271000494 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 331271000495 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 331271000496 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 331271000497 HIGH motif; other site 331271000498 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331271000499 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331271000500 active site 331271000501 KMSKS motif; other site 331271000502 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 331271000503 tRNA binding surface [nucleotide binding]; other site 331271000504 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331271000505 Lipopolysaccharide-assembly; Region: LptE; cl01125 331271000506 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 331271000507 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 331271000508 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 331271000509 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 331271000510 putative catalytic cysteine [active] 331271000511 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 331271000512 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 331271000513 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271000514 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 331271000515 putative active site [active] 331271000516 phosphogluconate dehydratase; Validated; Region: PRK09054 331271000517 6-phosphogluconate dehydratase; Region: edd; TIGR01196 331271000518 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 331271000519 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 331271000520 active site 331271000521 intersubunit interface [polypeptide binding]; other site 331271000522 catalytic residue [active] 331271000523 fructuronate transporter; Provisional; Region: PRK10034; cl15264 331271000524 GntP family permease; Region: GntP_permease; pfam02447 331271000525 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 331271000526 ATP-binding site [chemical binding]; other site 331271000527 Gluconate-6-phosphate binding site [chemical binding]; other site 331271000528 Shikimate kinase; Region: SKI; pfam01202 331271000529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271000530 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 331271000531 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271000532 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271000533 adenylosuccinate lyase; Provisional; Region: PRK09285 331271000534 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 331271000535 tetramer interface [polypeptide binding]; other site 331271000536 active site 331271000537 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271000538 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271000539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271000540 dimerization interface [polypeptide binding]; other site 331271000541 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 331271000542 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 331271000543 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 331271000544 NAD(P) binding site [chemical binding]; other site 331271000545 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271000546 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271000547 substrate binding pocket [chemical binding]; other site 331271000548 membrane-bound complex binding site; other site 331271000549 hinge residues; other site 331271000550 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271000551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271000552 dimer interface [polypeptide binding]; other site 331271000553 conserved gate region; other site 331271000554 putative PBP binding loops; other site 331271000555 ABC-ATPase subunit interface; other site 331271000556 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271000558 dimer interface [polypeptide binding]; other site 331271000559 conserved gate region; other site 331271000560 putative PBP binding loops; other site 331271000561 ABC-ATPase subunit interface; other site 331271000562 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 331271000563 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271000564 Walker A/P-loop; other site 331271000565 ATP binding site [chemical binding]; other site 331271000566 Q-loop/lid; other site 331271000567 ABC transporter signature motif; other site 331271000568 Walker B; other site 331271000569 D-loop; other site 331271000570 H-loop/switch region; other site 331271000571 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 331271000572 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 331271000573 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 331271000574 Autotransporter beta-domain; Region: Autotransporter; smart00869 331271000575 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 331271000576 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 331271000577 putative active site [active] 331271000578 putative dimer interface [polypeptide binding]; other site 331271000579 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 331271000580 active site 331271000581 substrate binding pocket [chemical binding]; other site 331271000582 dimer interface [polypeptide binding]; other site 331271000583 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 331271000584 OsmC-like protein; Region: OsmC; cl00767 331271000585 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 331271000586 23S rRNA interface [nucleotide binding]; other site 331271000587 L3 interface [polypeptide binding]; other site 331271000588 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 331271000589 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 331271000590 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 331271000591 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 331271000592 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 331271000593 active site 331271000594 HIGH motif; other site 331271000595 dimer interface [polypeptide binding]; other site 331271000596 KMSKS motif; other site 331271000597 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331271000598 RNA binding surface [nucleotide binding]; other site 331271000599 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 331271000600 putative active site [active] 331271000601 dimerization interface [polypeptide binding]; other site 331271000602 putative tRNAtyr binding site [nucleotide binding]; other site 331271000603 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331271000604 catalytic core [active] 331271000605 Putative ParB-like nuclease; Region: ParBc_2; cl17538 331271000606 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 331271000607 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 331271000608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271000609 Walker A motif; other site 331271000610 ATP binding site [chemical binding]; other site 331271000611 Walker B motif; other site 331271000612 arginine finger; other site 331271000613 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 331271000614 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 331271000615 RuvA N terminal domain; Region: RuvA_N; pfam01330 331271000616 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 331271000617 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 331271000618 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 331271000619 active site 331271000620 putative DNA-binding cleft [nucleotide binding]; other site 331271000621 dimer interface [polypeptide binding]; other site 331271000622 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 331271000623 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 331271000624 purine monophosphate binding site [chemical binding]; other site 331271000625 dimer interface [polypeptide binding]; other site 331271000626 putative catalytic residues [active] 331271000627 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 331271000628 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 331271000629 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 331271000630 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 331271000631 FMN binding site [chemical binding]; other site 331271000632 active site 331271000633 catalytic residues [active] 331271000634 substrate binding site [chemical binding]; other site 331271000635 hypothetical protein; Provisional; Region: PRK06996 331271000636 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271000637 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 331271000638 proline aminopeptidase P II; Provisional; Region: PRK10879 331271000639 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 331271000640 active site 331271000641 putative glutathione S-transferase; Provisional; Region: PRK10357 331271000642 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 331271000643 putative C-terminal domain interface [polypeptide binding]; other site 331271000644 putative GSH binding site (G-site) [chemical binding]; other site 331271000645 putative dimer interface [polypeptide binding]; other site 331271000646 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 331271000647 dimer interface [polypeptide binding]; other site 331271000648 N-terminal domain interface [polypeptide binding]; other site 331271000649 putative substrate binding pocket (H-site) [chemical binding]; other site 331271000650 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 331271000651 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331271000652 active site 331271000653 FMN binding site [chemical binding]; other site 331271000654 substrate binding site [chemical binding]; other site 331271000655 3Fe-4S cluster binding site [ion binding]; other site 331271000656 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 331271000657 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 331271000658 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 331271000659 nudix motif; other site 331271000660 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 331271000661 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 331271000662 ligand binding site [chemical binding]; other site 331271000663 homodimer interface [polypeptide binding]; other site 331271000664 NAD(P) binding site [chemical binding]; other site 331271000665 trimer interface B [polypeptide binding]; other site 331271000666 trimer interface A [polypeptide binding]; other site 331271000667 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 331271000668 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 331271000669 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 331271000670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271000671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271000672 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 331271000673 putative substrate binding pocket [chemical binding]; other site 331271000674 putative dimerization interface [polypeptide binding]; other site 331271000675 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 331271000676 Predicted amidohydrolase [General function prediction only]; Region: COG0388 331271000677 putative active site [active] 331271000678 catalytic triad [active] 331271000679 putative dimer interface [polypeptide binding]; other site 331271000680 Predicted transcriptional regulator [Transcription]; Region: COG2378 331271000681 HTH domain; Region: HTH_11; pfam08279 331271000682 WYL domain; Region: WYL; pfam13280 331271000683 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 331271000684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271000685 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331271000686 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 331271000687 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 331271000688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331271000689 Site-specific recombinase; Region: SpecificRecomb; pfam10136 331271000690 Protein of unknown function (DUF330); Region: DUF330; pfam03886 331271000691 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 331271000692 mce related protein; Region: MCE; pfam02470 331271000693 mce related protein; Region: MCE; pfam02470 331271000694 Paraquat-inducible protein A; Region: PqiA; pfam04403 331271000695 Paraquat-inducible protein A; Region: PqiA; pfam04403 331271000696 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 331271000697 YceI-like domain; Region: YceI; smart00867 331271000698 Uncharacterized conserved protein [Function unknown]; Region: COG2353 331271000699 citrate-proton symporter; Provisional; Region: PRK15075 331271000700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271000701 putative substrate translocation pore; other site 331271000702 C-terminal peptidase (prc); Region: prc; TIGR00225 331271000703 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331271000704 protein binding site [polypeptide binding]; other site 331271000705 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331271000706 Active site serine [active] 331271000707 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 331271000708 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 331271000709 Protein export membrane protein; Region: SecD_SecF; pfam02355 331271000710 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 331271000711 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 331271000712 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 331271000713 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 331271000714 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 331271000715 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 331271000716 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 331271000717 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 331271000718 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 331271000719 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 331271000720 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 331271000721 ssDNA binding site; other site 331271000722 generic binding surface II; other site 331271000723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331271000724 ATP binding site [chemical binding]; other site 331271000725 putative Mg++ binding site [ion binding]; other site 331271000726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271000727 nucleotide binding region [chemical binding]; other site 331271000728 ATP-binding site [chemical binding]; other site 331271000729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271000730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271000731 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 331271000732 dimerization interface [polypeptide binding]; other site 331271000733 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 331271000734 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 331271000735 dimer interface [polypeptide binding]; other site 331271000736 active site 331271000737 heme binding site [chemical binding]; other site 331271000738 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 331271000739 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 331271000740 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 331271000741 dimerization interface [polypeptide binding]; other site 331271000742 DPS ferroxidase diiron center [ion binding]; other site 331271000743 ion pore; other site 331271000744 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 331271000745 UbiA prenyltransferase family; Region: UbiA; pfam01040 331271000746 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 331271000747 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 331271000748 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 331271000749 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331271000750 catalytic residue [active] 331271000751 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 331271000752 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331271000753 Cysteine-rich domain; Region: CCG; pfam02754 331271000754 Cysteine-rich domain; Region: CCG; pfam02754 331271000755 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 331271000756 FAD binding domain; Region: FAD_binding_4; pfam01565 331271000757 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 331271000758 FAD binding domain; Region: FAD_binding_4; pfam01565 331271000759 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331271000760 FAD binding domain; Region: FAD_binding_4; pfam01565 331271000761 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 331271000762 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 331271000763 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 331271000764 heme-binding site [chemical binding]; other site 331271000765 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 331271000766 FAD binding pocket [chemical binding]; other site 331271000767 FAD binding motif [chemical binding]; other site 331271000768 phosphate binding motif [ion binding]; other site 331271000769 beta-alpha-beta structure motif; other site 331271000770 NAD binding pocket [chemical binding]; other site 331271000771 Heme binding pocket [chemical binding]; other site 331271000772 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 331271000773 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331271000774 protease TldD; Provisional; Region: tldD; PRK10735 331271000775 nitrilase; Region: PLN02798 331271000776 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 331271000777 putative active site [active] 331271000778 catalytic triad [active] 331271000779 dimer interface [polypeptide binding]; other site 331271000780 TIGR02099 family protein; Region: TIGR02099 331271000781 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 331271000782 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 331271000783 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 331271000784 metal binding triad; other site 331271000785 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 331271000786 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 331271000787 metal binding triad; other site 331271000788 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 331271000789 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 331271000790 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 331271000791 Walker A/P-loop; other site 331271000792 ATP binding site [chemical binding]; other site 331271000793 Q-loop/lid; other site 331271000794 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 331271000795 ABC transporter signature motif; other site 331271000796 Walker B; other site 331271000797 D-loop; other site 331271000798 H-loop/switch region; other site 331271000799 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 331271000800 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 331271000801 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 331271000802 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 331271000803 ferrochelatase; Reviewed; Region: hemH; PRK00035 331271000804 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 331271000805 C-terminal domain interface [polypeptide binding]; other site 331271000806 active site 331271000807 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 331271000808 active site 331271000809 N-terminal domain interface [polypeptide binding]; other site 331271000810 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331271000811 RNA binding surface [nucleotide binding]; other site 331271000812 GrpE; Region: GrpE; pfam01025 331271000813 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 331271000814 dimer interface [polypeptide binding]; other site 331271000815 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 331271000816 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331271000817 catalytic residues [active] 331271000818 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 331271000819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 331271000820 nucleotide binding site [chemical binding]; other site 331271000821 chaperone protein DnaJ; Provisional; Region: PRK10767 331271000822 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 331271000823 HSP70 interaction site [polypeptide binding]; other site 331271000824 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 331271000825 Zn binding sites [ion binding]; other site 331271000826 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 331271000827 dimer interface [polypeptide binding]; other site 331271000828 chorismate binding enzyme; Region: Chorismate_bind; cl10555 331271000829 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 331271000830 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 331271000831 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 331271000832 homodimer interface [polypeptide binding]; other site 331271000833 substrate-cofactor binding pocket; other site 331271000834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271000835 catalytic residue [active] 331271000836 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 331271000837 oligomerization interface [polypeptide binding]; other site 331271000838 active site 331271000839 metal binding site [ion binding]; metal-binding site 331271000840 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 331271000841 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 331271000842 Substrate-binding site [chemical binding]; other site 331271000843 Substrate specificity [chemical binding]; other site 331271000844 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 331271000845 catalytic center binding site [active] 331271000846 ATP binding site [chemical binding]; other site 331271000847 poly(A) polymerase; Region: pcnB; TIGR01942 331271000848 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 331271000849 active site 331271000850 NTP binding site [chemical binding]; other site 331271000851 metal binding triad [ion binding]; metal-binding site 331271000852 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 331271000853 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 331271000854 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 331271000855 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 331271000856 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 331271000857 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 331271000858 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 331271000859 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 331271000860 dimerization interface [polypeptide binding]; other site 331271000861 putative ATP binding site [chemical binding]; other site 331271000862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271000863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271000864 putative substrate translocation pore; other site 331271000865 tetracycline repressor protein TetR; Provisional; Region: PRK13756 331271000866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271000867 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 331271000868 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 331271000869 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 331271000870 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 331271000871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271000872 ATP binding site [chemical binding]; other site 331271000873 Mg2+ binding site [ion binding]; other site 331271000874 G-X-G motif; other site 331271000875 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 331271000876 ATP binding site [chemical binding]; other site 331271000877 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 331271000878 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 331271000879 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 331271000880 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331271000881 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271000882 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 331271000883 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 331271000884 polysaccharide export protein Wza; Provisional; Region: PRK15078 331271000885 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 331271000886 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331271000887 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 331271000888 Probable Catalytic site; other site 331271000889 metal-binding site 331271000890 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331271000891 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 331271000892 Probable Catalytic site; other site 331271000893 metal-binding site 331271000894 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 331271000895 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 331271000896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271000897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271000898 binding surface 331271000899 TPR motif; other site 331271000900 TPR repeat; Region: TPR_11; pfam13414 331271000901 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271000902 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271000903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331271000904 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 331271000905 Walker A/P-loop; other site 331271000906 ATP binding site [chemical binding]; other site 331271000907 Q-loop/lid; other site 331271000908 ABC transporter signature motif; other site 331271000909 Walker B; other site 331271000910 D-loop; other site 331271000911 H-loop/switch region; other site 331271000912 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 331271000913 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 331271000914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 331271000915 Integrase core domain; Region: rve; pfam00665 331271000916 Integrase core domain; Region: rve_3; pfam13683 331271000917 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 331271000918 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 331271000919 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 331271000920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271000921 NAD(P) binding site [chemical binding]; other site 331271000922 active site 331271000923 Sulfatase; Region: Sulfatase; pfam00884 331271000924 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 331271000925 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 331271000926 active site 331271000927 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 331271000928 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 331271000929 Methyltransferase domain; Region: Methyltransf_12; pfam08242 331271000930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271000931 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 331271000932 Enoylreductase; Region: PKS_ER; smart00829 331271000933 NAD(P) binding site [chemical binding]; other site 331271000934 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 331271000935 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 331271000936 putative NADP binding site [chemical binding]; other site 331271000937 active site 331271000938 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 331271000939 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 331271000940 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 331271000941 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 331271000942 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 331271000943 substrate-cofactor binding pocket; other site 331271000944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271000945 catalytic residue [active] 331271000946 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271000947 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 331271000948 ligand-binding site [chemical binding]; other site 331271000949 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 331271000950 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 331271000951 putative active site [active] 331271000952 putative dimer interface [polypeptide binding]; other site 331271000953 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 331271000954 Cupin; Region: Cupin_6; pfam12852 331271000955 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271000956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271000957 yiaA/B two helix domain; Region: YiaAB; pfam05360 331271000958 yiaA/B two helix domain; Region: YiaAB; pfam05360 331271000959 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 331271000960 PemK-like protein; Region: PemK; pfam02452 331271000961 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 331271000962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271000963 non-specific DNA binding site [nucleotide binding]; other site 331271000964 salt bridge; other site 331271000965 sequence-specific DNA binding site [nucleotide binding]; other site 331271000966 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 331271000967 Tetratricopeptide repeat; Region: TPR_6; pfam13174 331271000968 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331271000969 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271000970 ligand binding site [chemical binding]; other site 331271000971 translocation protein TolB; Provisional; Region: tolB; PRK02889 331271000972 TolB amino-terminal domain; Region: TolB_N; pfam04052 331271000973 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331271000974 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331271000975 TolA protein; Region: tolA_full; TIGR02794 331271000976 TonB C terminal; Region: TonB_2; pfam13103 331271000977 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 331271000978 TolR protein; Region: tolR; TIGR02801 331271000979 TolQ protein; Region: tolQ; TIGR02796 331271000980 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 331271000981 active site 331271000982 malonic semialdehyde reductase; Provisional; Region: PRK10538 331271000983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271000984 NAD(P) binding site [chemical binding]; other site 331271000985 active site 331271000986 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 331271000987 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 331271000988 dimer interface [polypeptide binding]; other site 331271000989 active site 331271000990 glycine-pyridoxal phosphate binding site [chemical binding]; other site 331271000991 folate binding site [chemical binding]; other site 331271000992 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 331271000993 ATP cone domain; Region: ATP-cone; pfam03477 331271000994 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 331271000995 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 331271000996 Predicted membrane protein [Function unknown]; Region: COG5393 331271000997 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 331271000998 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 331271000999 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 331271001000 dimer interface [polypeptide binding]; other site 331271001001 decamer (pentamer of dimers) interface [polypeptide binding]; other site 331271001002 catalytic triad [active] 331271001003 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 331271001004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271001005 FAD binding site [chemical binding]; other site 331271001006 substrate binding pocket [chemical binding]; other site 331271001007 catalytic base [active] 331271001008 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271001009 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271001010 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271001011 Uncharacterized conserved protein [Function unknown]; Region: COG3791 331271001012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 331271001013 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 331271001014 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271001015 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271001016 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 331271001017 benzoate transport; Region: 2A0115; TIGR00895 331271001018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001019 putative substrate translocation pore; other site 331271001020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001021 putative substrate translocation pore; other site 331271001022 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 331271001023 fumarylacetoacetase; Region: PLN02856 331271001024 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 331271001025 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271001026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271001028 putative substrate translocation pore; other site 331271001029 MFS transport protein AraJ; Provisional; Region: PRK10091 331271001030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001031 putative substrate translocation pore; other site 331271001032 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 331271001033 putative FMN binding site [chemical binding]; other site 331271001034 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 331271001035 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 331271001036 putative ligand binding site [chemical binding]; other site 331271001037 putative NAD binding site [chemical binding]; other site 331271001038 catalytic site [active] 331271001039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271001040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271001041 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271001042 putative effector binding pocket; other site 331271001043 dimerization interface [polypeptide binding]; other site 331271001044 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 331271001045 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271001046 catalytic residue [active] 331271001047 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271001048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271001049 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 331271001050 EamA-like transporter family; Region: EamA; pfam00892 331271001051 major facilitator superfamily transporter; Provisional; Region: PRK05122 331271001052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001053 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 331271001054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271001055 catalytic loop [active] 331271001056 iron binding site [ion binding]; other site 331271001057 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271001058 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 331271001059 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 331271001060 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271001061 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271001062 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 331271001063 XdhC Rossmann domain; Region: XdhC_C; pfam13478 331271001064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 331271001065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271001066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271001067 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271001068 dimerization interface [polypeptide binding]; other site 331271001069 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 331271001070 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 331271001071 putative catalytic residue [active] 331271001072 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271001073 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271001074 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 331271001075 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 331271001076 BON domain; Region: BON; pfam04972 331271001077 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 331271001078 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 331271001079 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 331271001080 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331271001081 active site 331271001082 NTP binding site [chemical binding]; other site 331271001083 metal binding triad [ion binding]; metal-binding site 331271001084 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331271001085 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271001086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001087 putative substrate translocation pore; other site 331271001088 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 331271001089 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 331271001090 catalytic residues [active] 331271001091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 331271001092 YheO-like PAS domain; Region: PAS_6; pfam08348 331271001093 HTH domain; Region: HTH_22; pfam13309 331271001094 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 331271001095 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 331271001096 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 331271001097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271001098 substrate binding pocket [chemical binding]; other site 331271001099 membrane-bound complex binding site; other site 331271001100 hinge residues; other site 331271001101 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271001102 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271001103 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 331271001104 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 331271001105 RNA polymerase sigma factor; Provisional; Region: PRK12511 331271001106 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271001107 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 331271001108 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 331271001109 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 331271001110 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 331271001111 putative hydrophobic ligand binding site [chemical binding]; other site 331271001112 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 331271001113 oligomerisation interface [polypeptide binding]; other site 331271001114 mobile loop; other site 331271001115 roof hairpin; other site 331271001116 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 331271001117 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 331271001118 ring oligomerisation interface [polypeptide binding]; other site 331271001119 ATP/Mg binding site [chemical binding]; other site 331271001120 stacking interactions; other site 331271001121 hinge regions; other site 331271001122 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 331271001123 dimer interface [polypeptide binding]; other site 331271001124 substrate binding site [chemical binding]; other site 331271001125 ATP binding site [chemical binding]; other site 331271001126 Rubredoxin [Energy production and conversion]; Region: COG1773 331271001127 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331271001128 iron binding site [ion binding]; other site 331271001129 hypothetical protein; Validated; Region: PRK00228 331271001130 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 331271001131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271001132 active site 331271001133 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 331271001134 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 331271001135 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 331271001136 dihydroorotase; Provisional; Region: PRK07627 331271001137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271001138 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 331271001139 active site 331271001140 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331271001141 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331271001142 putative acyl-acceptor binding pocket; other site 331271001143 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 331271001144 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 331271001145 active site 331271001146 metal binding site [ion binding]; metal-binding site 331271001147 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331271001148 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331271001149 NAD binding site [chemical binding]; other site 331271001150 substrate binding site [chemical binding]; other site 331271001151 homodimer interface [polypeptide binding]; other site 331271001152 active site 331271001153 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 331271001154 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 331271001155 substrate binding site; other site 331271001156 tetramer interface; other site 331271001157 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 331271001158 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 331271001159 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 331271001160 NADP binding site [chemical binding]; other site 331271001161 active site 331271001162 putative substrate binding site [chemical binding]; other site 331271001163 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 331271001164 Ligand binding site; other site 331271001165 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 331271001166 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 331271001167 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 331271001168 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 331271001169 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 331271001170 Walker A/P-loop; other site 331271001171 ATP binding site [chemical binding]; other site 331271001172 Q-loop/lid; other site 331271001173 ABC transporter signature motif; other site 331271001174 Walker B; other site 331271001175 D-loop; other site 331271001176 H-loop/switch region; other site 331271001177 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331271001178 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 331271001179 Probable Catalytic site; other site 331271001180 metal-binding site 331271001181 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331271001182 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 331271001183 Probable Catalytic site; other site 331271001184 metal-binding site 331271001185 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 331271001186 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 331271001187 Substrate binding site; other site 331271001188 Cupin domain; Region: Cupin_2; cl17218 331271001189 Transposase, Mutator family; Region: Transposase_mut; pfam00872 331271001190 MULE transposase domain; Region: MULE; pfam10551 331271001191 Cupin domain; Region: Cupin_2; cl17218 331271001192 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 331271001193 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 331271001194 NADP-binding site; other site 331271001195 homotetramer interface [polypeptide binding]; other site 331271001196 substrate binding site [chemical binding]; other site 331271001197 homodimer interface [polypeptide binding]; other site 331271001198 active site 331271001199 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 331271001200 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 331271001201 NADP-binding site; other site 331271001202 homotetramer interface [polypeptide binding]; other site 331271001203 substrate binding site [chemical binding]; other site 331271001204 homodimer interface [polypeptide binding]; other site 331271001205 active site 331271001206 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 331271001207 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 331271001208 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 331271001209 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 331271001210 Probable Catalytic site; other site 331271001211 metal-binding site 331271001212 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 331271001213 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 331271001214 Probable Catalytic site; other site 331271001215 metal-binding site 331271001216 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 331271001217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271001218 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 331271001219 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331271001220 active site 331271001221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331271001222 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271001223 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 331271001224 putative NAD(P) binding site [chemical binding]; other site 331271001225 active site 331271001226 putative substrate binding site [chemical binding]; other site 331271001227 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 331271001228 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 331271001229 Mg++ binding site [ion binding]; other site 331271001230 putative catalytic motif [active] 331271001231 putative substrate binding site [chemical binding]; other site 331271001232 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 331271001233 CoA binding domain; Region: CoA_binding; cl17356 331271001234 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 331271001235 NAD(P) binding site [chemical binding]; other site 331271001236 homodimer interface [polypeptide binding]; other site 331271001237 substrate binding site [chemical binding]; other site 331271001238 active site 331271001239 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 331271001240 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 331271001241 Mg++ binding site [ion binding]; other site 331271001242 putative catalytic motif [active] 331271001243 UDP-glucose 4-epimerase; Region: PLN02240 331271001244 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 331271001245 NAD binding site [chemical binding]; other site 331271001246 homodimer interface [polypeptide binding]; other site 331271001247 active site 331271001248 substrate binding site [chemical binding]; other site 331271001249 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 331271001250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271001251 putative ADP-binding pocket [chemical binding]; other site 331271001252 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331271001253 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331271001254 active site 331271001255 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 331271001256 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 331271001257 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 331271001258 active site 331271001259 substrate binding site [chemical binding]; other site 331271001260 metal binding site [ion binding]; metal-binding site 331271001261 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331271001262 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331271001263 putative active site [active] 331271001264 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 331271001265 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 331271001266 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 331271001267 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271001268 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331271001269 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 331271001270 UreF; Region: UreF; pfam01730 331271001271 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 331271001272 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 331271001273 dimer interface [polypeptide binding]; other site 331271001274 catalytic residues [active] 331271001275 urease subunit alpha; Reviewed; Region: ureC; PRK13207 331271001276 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 331271001277 subunit interactions [polypeptide binding]; other site 331271001278 active site 331271001279 flap region; other site 331271001280 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 331271001281 gamma-beta subunit interface [polypeptide binding]; other site 331271001282 alpha-beta subunit interface [polypeptide binding]; other site 331271001283 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 331271001284 alpha-gamma subunit interface [polypeptide binding]; other site 331271001285 beta-gamma subunit interface [polypeptide binding]; other site 331271001286 UreD urease accessory protein; Region: UreD; cl00530 331271001287 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 331271001288 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 331271001289 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 331271001290 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 331271001291 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271001292 Walker A/P-loop; other site 331271001293 ATP binding site [chemical binding]; other site 331271001294 Q-loop/lid; other site 331271001295 ABC transporter signature motif; other site 331271001296 Walker B; other site 331271001297 D-loop; other site 331271001298 H-loop/switch region; other site 331271001299 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 331271001300 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271001301 Walker A/P-loop; other site 331271001302 ATP binding site [chemical binding]; other site 331271001303 Q-loop/lid; other site 331271001304 ABC transporter signature motif; other site 331271001305 Walker B; other site 331271001306 D-loop; other site 331271001307 H-loop/switch region; other site 331271001308 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331271001309 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271001310 TM-ABC transporter signature motif; other site 331271001311 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271001312 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271001313 TM-ABC transporter signature motif; other site 331271001314 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 331271001315 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 331271001316 putative ligand binding site [chemical binding]; other site 331271001317 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 331271001318 active site residue [active] 331271001319 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 331271001320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271001321 S-adenosylmethionine binding site [chemical binding]; other site 331271001322 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 331271001323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271001324 FeS/SAM binding site; other site 331271001325 HemN C-terminal domain; Region: HemN_C; pfam06969 331271001326 Flagellin N-methylase; Region: FliB; pfam03692 331271001327 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 331271001328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271001329 S-adenosylmethionine binding site [chemical binding]; other site 331271001330 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331271001331 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271001332 P-loop; other site 331271001333 Magnesium ion binding site [ion binding]; other site 331271001334 L-asparaginase II; Region: Asparaginase_II; cl01842 331271001335 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271001336 Magnesium ion binding site [ion binding]; other site 331271001337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271001338 sequence-specific DNA binding site [nucleotide binding]; other site 331271001339 salt bridge; other site 331271001340 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 331271001341 active site 331271001342 catalytic residues [active] 331271001343 DNA binding site [nucleotide binding] 331271001344 Int/Topo IB signature motif; other site 331271001345 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 331271001346 polymerase nucleotide-binding site; other site 331271001347 DNA-binding residues [nucleotide binding]; DNA binding site 331271001348 nucleotide binding site [chemical binding]; other site 331271001349 primase nucleotide-binding site [nucleotide binding]; other site 331271001350 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 331271001351 hypothetical protein; Provisional; Region: PRK14709 331271001352 D5 N terminal like; Region: D5_N; smart00885 331271001353 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 331271001354 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 331271001355 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 331271001356 metal binding site [ion binding]; metal-binding site 331271001357 substrate binding pocket [chemical binding]; other site 331271001358 LysE type translocator; Region: LysE; cl00565 331271001359 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 331271001360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271001361 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 331271001362 putative dimerization interface [polypeptide binding]; other site 331271001363 benzoate transport; Region: 2A0115; TIGR00895 331271001364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001365 putative substrate translocation pore; other site 331271001366 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271001367 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271001368 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 331271001369 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271001370 substrate binding site [chemical binding]; other site 331271001371 oxyanion hole (OAH) forming residues; other site 331271001372 trimer interface [polypeptide binding]; other site 331271001373 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 331271001374 Chromate transporter; Region: Chromate_transp; pfam02417 331271001375 Chromate transporter; Region: Chromate_transp; pfam02417 331271001376 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 331271001377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271001378 DNA-binding site [nucleotide binding]; DNA binding site 331271001379 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 331271001380 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 331271001381 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 331271001382 dimer interface [polypeptide binding]; other site 331271001383 ADP-ribose binding site [chemical binding]; other site 331271001384 active site 331271001385 nudix motif; other site 331271001386 metal binding site [ion binding]; metal-binding site 331271001387 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 331271001388 NAD-dependent deacetylase; Provisional; Region: PRK00481 331271001389 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 331271001390 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271001391 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 331271001392 active site 331271001393 catalytic triad [active] 331271001394 calcium binding site [ion binding]; other site 331271001395 chromosome condensation membrane protein; Provisional; Region: PRK14196 331271001396 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 331271001397 YGGT family; Region: YGGT; pfam02325 331271001398 YGGT family; Region: YGGT; pfam02325 331271001399 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 331271001400 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 331271001401 LysE type translocator; Region: LysE; cl00565 331271001402 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 331271001403 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 331271001404 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271001405 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271001406 catalytic residue [active] 331271001407 aminotransferase; Validated; Region: PRK07337 331271001408 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271001409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271001410 homodimer interface [polypeptide binding]; other site 331271001411 catalytic residue [active] 331271001412 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 331271001413 putative RNA binding site [nucleotide binding]; other site 331271001414 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 331271001415 homopentamer interface [polypeptide binding]; other site 331271001416 active site 331271001417 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 331271001418 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 331271001419 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 331271001420 dimerization interface [polypeptide binding]; other site 331271001421 active site 331271001422 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 331271001423 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 331271001424 Lumazine binding domain; Region: Lum_binding; pfam00677 331271001425 Lumazine binding domain; Region: Lum_binding; pfam00677 331271001426 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 331271001427 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 331271001428 catalytic motif [active] 331271001429 Zn binding site [ion binding]; other site 331271001430 RibD C-terminal domain; Region: RibD_C; cl17279 331271001431 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 331271001432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271001433 inhibitor-cofactor binding pocket; inhibition site 331271001434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271001435 catalytic residue [active] 331271001436 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 331271001437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001438 putative substrate translocation pore; other site 331271001439 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 331271001440 glucokinase; Provisional; Region: glk; PRK00292 331271001441 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271001442 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 331271001443 putative active site [active] 331271001444 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 331271001445 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 331271001446 putative active site [active] 331271001447 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 331271001448 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 331271001449 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 331271001450 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 331271001451 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 331271001452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271001453 dimer interface [polypeptide binding]; other site 331271001454 conserved gate region; other site 331271001455 putative PBP binding loops; other site 331271001456 ABC-ATPase subunit interface; other site 331271001457 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271001458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271001459 dimer interface [polypeptide binding]; other site 331271001460 conserved gate region; other site 331271001461 putative PBP binding loops; other site 331271001462 ABC-ATPase subunit interface; other site 331271001463 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 331271001464 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 331271001465 Walker A/P-loop; other site 331271001466 ATP binding site [chemical binding]; other site 331271001467 Q-loop/lid; other site 331271001468 ABC transporter signature motif; other site 331271001469 Walker B; other site 331271001470 D-loop; other site 331271001471 H-loop/switch region; other site 331271001472 TOBE domain; Region: TOBE_2; pfam08402 331271001473 Predicted membrane protein [Function unknown]; Region: COG2860 331271001474 UPF0126 domain; Region: UPF0126; pfam03458 331271001475 UPF0126 domain; Region: UPF0126; pfam03458 331271001476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 331271001477 Smr domain; Region: Smr; pfam01713 331271001478 thioredoxin reductase; Provisional; Region: PRK10262 331271001479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271001480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271001481 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 331271001482 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 331271001483 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 331271001484 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 331271001485 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 331271001486 recombination factor protein RarA; Reviewed; Region: PRK13342 331271001487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271001488 Walker A motif; other site 331271001489 ATP binding site [chemical binding]; other site 331271001490 Walker B motif; other site 331271001491 arginine finger; other site 331271001492 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 331271001493 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 331271001494 seryl-tRNA synthetase; Provisional; Region: PRK05431 331271001495 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 331271001496 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 331271001497 dimer interface [polypeptide binding]; other site 331271001498 active site 331271001499 motif 1; other site 331271001500 motif 2; other site 331271001501 motif 3; other site 331271001502 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 331271001503 Fatty acid desaturase; Region: FA_desaturase; pfam00487 331271001504 Di-iron ligands [ion binding]; other site 331271001505 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271001506 septum formation inhibitor; Reviewed; Region: PRK01973 331271001507 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 331271001508 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 331271001509 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 331271001510 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 331271001511 Switch I; other site 331271001512 Switch II; other site 331271001513 cell division topological specificity factor MinE; Provisional; Region: PRK13989 331271001514 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 331271001515 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 331271001516 putative ion selectivity filter; other site 331271001517 putative pore gating glutamate residue; other site 331271001518 putative H+/Cl- coupling transport residue; other site 331271001519 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331271001520 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331271001521 putative active site [active] 331271001522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001523 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271001524 putative substrate translocation pore; other site 331271001525 Gram-negative bacterial tonB protein; Region: TonB; cl10048 331271001526 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 331271001527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271001528 FeS/SAM binding site; other site 331271001529 HemN C-terminal domain; Region: HemN_C; pfam06969 331271001530 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 331271001531 active site 331271001532 dimerization interface [polypeptide binding]; other site 331271001533 ribonuclease PH; Reviewed; Region: rph; PRK00173 331271001534 Ribonuclease PH; Region: RNase_PH_bact; cd11362 331271001535 hexamer interface [polypeptide binding]; other site 331271001536 active site 331271001537 hypothetical protein; Provisional; Region: PRK11820 331271001538 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 331271001539 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 331271001540 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 331271001541 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 331271001542 catalytic site [active] 331271001543 G-X2-G-X-G-K; other site 331271001544 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 331271001545 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 331271001546 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331271001547 Zn2+ binding site [ion binding]; other site 331271001548 Mg2+ binding site [ion binding]; other site 331271001549 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 331271001550 synthetase active site [active] 331271001551 NTP binding site [chemical binding]; other site 331271001552 metal binding site [ion binding]; metal-binding site 331271001553 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 331271001554 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 331271001555 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 331271001556 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 331271001557 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 331271001558 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271001559 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271001560 trimer interface [polypeptide binding]; other site 331271001561 eyelet of channel; other site 331271001562 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 331271001563 DNA-binding site [nucleotide binding]; DNA binding site 331271001564 RNA-binding motif; other site 331271001565 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331271001566 active site 331271001567 catalytic site [active] 331271001568 substrate binding site [chemical binding]; other site 331271001569 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 331271001570 GIY-YIG motif/motif A; other site 331271001571 active site 331271001572 catalytic site [active] 331271001573 putative DNA binding site [nucleotide binding]; other site 331271001574 metal binding site [ion binding]; metal-binding site 331271001575 chorismate mutase; Provisional; Region: PRK09269 331271001576 Chorismate mutase type II; Region: CM_2; cl00693 331271001577 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 331271001578 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 331271001579 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271001580 N-terminal plug; other site 331271001581 ligand-binding site [chemical binding]; other site 331271001582 fructose-1,6-bisphosphatase family protein; Region: PLN02628 331271001583 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 331271001584 AMP binding site [chemical binding]; other site 331271001585 metal binding site [ion binding]; metal-binding site 331271001586 active site 331271001587 aminopeptidase N; Provisional; Region: pepN; PRK14015 331271001588 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 331271001589 active site 331271001590 Zn binding site [ion binding]; other site 331271001591 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 331271001592 Predicted membrane protein [Function unknown]; Region: COG2119 331271001593 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 331271001594 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 331271001595 guanine deaminase; Provisional; Region: PRK09228 331271001596 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 331271001597 active site 331271001598 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 331271001599 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 331271001600 XdhC Rossmann domain; Region: XdhC_C; pfam13478 331271001601 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 331271001602 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 331271001603 active site 331271001604 purine riboside binding site [chemical binding]; other site 331271001605 disulfide bond formation protein B; Provisional; Region: PRK02110 331271001606 amidase; Provisional; Region: PRK07056 331271001607 Amidase; Region: Amidase; cl11426 331271001608 Transcriptional regulators [Transcription]; Region: GntR; COG1802 331271001609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271001610 DNA-binding site [nucleotide binding]; DNA binding site 331271001611 FCD domain; Region: FCD; pfam07729 331271001612 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 331271001613 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 331271001614 catalytic triad [active] 331271001615 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 331271001616 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995 331271001617 citrate-proton symporter; Provisional; Region: PRK15075 331271001618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271001619 putative substrate translocation pore; other site 331271001620 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 331271001621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271001622 binding surface 331271001623 TPR motif; other site 331271001624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271001625 binding surface 331271001626 TPR motif; other site 331271001627 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271001628 hypothetical protein; Provisional; Region: PRK06184 331271001629 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271001630 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 331271001631 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 331271001632 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271001633 catalytic loop [active] 331271001634 iron binding site [ion binding]; other site 331271001635 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 331271001636 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 331271001637 [4Fe-4S] binding site [ion binding]; other site 331271001638 molybdopterin cofactor binding site; other site 331271001639 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 331271001640 molybdopterin cofactor binding site; other site 331271001641 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 331271001642 putative dimer interface [polypeptide binding]; other site 331271001643 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 331271001644 SLBB domain; Region: SLBB; pfam10531 331271001645 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 331271001646 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 331271001647 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 331271001648 putative dimer interface [polypeptide binding]; other site 331271001649 [2Fe-2S] cluster binding site [ion binding]; other site 331271001650 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 331271001651 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 331271001652 PBP superfamily domain; Region: PBP_like; pfam12727 331271001653 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271001654 phosphoglycolate phosphatase; Provisional; Region: PRK13222 331271001655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271001656 motif II; other site 331271001657 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 331271001658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271001659 S-adenosylmethionine binding site [chemical binding]; other site 331271001660 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271001661 ligand binding site [chemical binding]; other site 331271001662 DNA gyrase subunit A; Validated; Region: PRK05560 331271001663 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 331271001664 CAP-like domain; other site 331271001665 active site 331271001666 primary dimer interface [polypeptide binding]; other site 331271001667 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331271001668 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331271001669 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331271001670 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331271001671 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331271001672 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331271001673 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 331271001674 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 331271001675 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 331271001676 homodimer interface [polypeptide binding]; other site 331271001677 substrate-cofactor binding pocket; other site 331271001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271001679 catalytic residue [active] 331271001680 Chorismate mutase type II; Region: CM_2; cl00693 331271001681 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 331271001682 Prephenate dehydratase; Region: PDT; pfam00800 331271001683 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 331271001684 putative L-Phe binding site [chemical binding]; other site 331271001685 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 331271001686 prephenate dehydrogenase; Validated; Region: PRK08507 331271001687 3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338 331271001688 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 331271001689 hinge; other site 331271001690 active site 331271001691 cytidylate kinase; Provisional; Region: cmk; PRK00023 331271001692 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 331271001693 CMP-binding site; other site 331271001694 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 331271001695 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 331271001696 RNA binding site [nucleotide binding]; other site 331271001697 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 331271001698 RNA binding site [nucleotide binding]; other site 331271001699 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 331271001700 RNA binding site [nucleotide binding]; other site 331271001701 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 331271001702 RNA binding site [nucleotide binding]; other site 331271001703 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 331271001704 RNA binding site [nucleotide binding]; other site 331271001705 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 331271001706 RNA binding site [nucleotide binding]; other site 331271001707 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331271001708 IHF dimer interface [polypeptide binding]; other site 331271001709 IHF - DNA interface [nucleotide binding]; other site 331271001710 tetratricopeptide repeat protein; Provisional; Region: PRK11788 331271001711 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271001712 binding surface 331271001713 TPR motif; other site 331271001714 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 331271001715 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 331271001716 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 331271001717 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 331271001718 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 331271001719 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271001720 putative ribose interaction site [chemical binding]; other site 331271001721 putative ADP binding site [chemical binding]; other site 331271001722 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 331271001723 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 331271001724 NADP binding site [chemical binding]; other site 331271001725 homopentamer interface [polypeptide binding]; other site 331271001726 substrate binding site [chemical binding]; other site 331271001727 active site 331271001728 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 331271001729 cysteine synthase B; Region: cysM; TIGR01138 331271001730 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331271001731 dimer interface [polypeptide binding]; other site 331271001732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271001733 catalytic residue [active] 331271001734 Transglycosylase SLT domain; Region: SLT_2; pfam13406 331271001735 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271001736 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271001737 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 331271001738 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 331271001739 putative active site [active] 331271001740 Zn binding site [ion binding]; other site 331271001741 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 331271001742 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271001743 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 331271001744 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 331271001745 Walker A/P-loop; other site 331271001746 ATP binding site [chemical binding]; other site 331271001747 Q-loop/lid; other site 331271001748 ABC transporter signature motif; other site 331271001749 Walker B; other site 331271001750 D-loop; other site 331271001751 H-loop/switch region; other site 331271001752 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 331271001753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271001754 dimer interface [polypeptide binding]; other site 331271001755 conserved gate region; other site 331271001756 ABC-ATPase subunit interface; other site 331271001757 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 331271001758 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 331271001759 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 331271001760 Ligand binding site [chemical binding]; other site 331271001761 Electron transfer flavoprotein domain; Region: ETF; pfam01012 331271001762 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 331271001763 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 331271001764 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 331271001765 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 331271001766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271001767 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271001768 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 331271001769 AsnC family; Region: AsnC_trans_reg; pfam01037 331271001770 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 331271001771 TM2 domain; Region: TM2; pfam05154 331271001772 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 331271001773 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 331271001774 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 331271001775 RimM N-terminal domain; Region: RimM; pfam01782 331271001776 PRC-barrel domain; Region: PRC; pfam05239 331271001777 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 331271001778 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 331271001779 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 331271001780 putative active site [active] 331271001781 putative CoA binding site [chemical binding]; other site 331271001782 nudix motif; other site 331271001783 metal binding site [ion binding]; metal-binding site 331271001784 CobD/CbiB family protein; Provisional; Region: PRK07630 331271001785 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 331271001786 GTPase RsgA; Reviewed; Region: PRK00098 331271001787 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 331271001788 RNA binding site [nucleotide binding]; other site 331271001789 homodimer interface [polypeptide binding]; other site 331271001790 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 331271001791 GTPase/Zn-binding domain interface [polypeptide binding]; other site 331271001792 GTP/Mg2+ binding site [chemical binding]; other site 331271001793 G4 box; other site 331271001794 G5 box; other site 331271001795 G1 box; other site 331271001796 Switch I region; other site 331271001797 G2 box; other site 331271001798 G3 box; other site 331271001799 Switch II region; other site 331271001800 Peptidase family M48; Region: Peptidase_M48; pfam01435 331271001801 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 331271001802 catalytic site [active] 331271001803 putative active site [active] 331271001804 putative substrate binding site [chemical binding]; other site 331271001805 dimer interface [polypeptide binding]; other site 331271001806 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 331271001807 MPT binding site; other site 331271001808 trimer interface [polypeptide binding]; other site 331271001809 hypothetical protein; Provisional; Region: PRK05255 331271001810 peptidase PmbA; Provisional; Region: PRK11040 331271001811 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 331271001812 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 331271001813 folate binding site [chemical binding]; other site 331271001814 NADP+ binding site [chemical binding]; other site 331271001815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271001816 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331271001817 Walker A motif; other site 331271001818 ATP binding site [chemical binding]; other site 331271001819 Walker B motif; other site 331271001820 arginine finger; other site 331271001821 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 331271001822 thymidylate synthase; Provisional; Region: thyA; PRK13821 331271001823 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 331271001824 dimerization interface [polypeptide binding]; other site 331271001825 active site 331271001826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271001827 dimerization interface [polypeptide binding]; other site 331271001828 putative DNA binding site [nucleotide binding]; other site 331271001829 putative Zn2+ binding site [ion binding]; other site 331271001830 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 331271001831 fumarate hydratase; Reviewed; Region: fumC; PRK00485 331271001832 Class II fumarases; Region: Fumarase_classII; cd01362 331271001833 active site 331271001834 tetramer interface [polypeptide binding]; other site 331271001835 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 331271001836 putative efflux protein, MATE family; Region: matE; TIGR00797 331271001837 cation binding site [ion binding]; other site 331271001838 S4 domain; Region: S4_2; pfam13275 331271001839 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 331271001840 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 331271001841 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 331271001842 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271001843 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271001844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271001845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271001846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 331271001847 CreA protein; Region: CreA; pfam05981 331271001848 Ferredoxin [Energy production and conversion]; Region: COG1146 331271001849 4Fe-4S binding domain; Region: Fer4; cl02805 331271001850 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 331271001851 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 331271001852 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 331271001853 active site 331271001854 Uncharacterized conserved protein [Function unknown]; Region: COG1556 331271001855 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 331271001856 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 331271001857 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 331271001858 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 331271001859 dimerization interface [polypeptide binding]; other site 331271001860 ligand binding site [chemical binding]; other site 331271001861 NADP binding site [chemical binding]; other site 331271001862 catalytic site [active] 331271001863 RmuC family; Region: RmuC; pfam02646 331271001864 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331271001865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271001866 Coenzyme A binding pocket [chemical binding]; other site 331271001867 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 331271001868 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 331271001869 dimer interface [polypeptide binding]; other site 331271001870 putative functional site; other site 331271001871 putative MPT binding site; other site 331271001872 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 331271001873 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 331271001874 GTP binding site; other site 331271001875 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 331271001876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271001877 FeS/SAM binding site; other site 331271001878 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 331271001879 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 331271001880 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 331271001881 homodimer interface [polypeptide binding]; other site 331271001882 oligonucleotide binding site [chemical binding]; other site 331271001883 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 331271001884 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 331271001885 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 331271001886 active site 331271001887 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331271001888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271001889 motif II; other site 331271001890 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 331271001891 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331271001892 iron-sulfur cluster [ion binding]; other site 331271001893 [2Fe-2S] cluster binding site [ion binding]; other site 331271001894 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 331271001895 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 331271001896 tandem repeat interface [polypeptide binding]; other site 331271001897 oligomer interface [polypeptide binding]; other site 331271001898 active site residues [active] 331271001899 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 331271001900 putative SAM binding site [chemical binding]; other site 331271001901 homodimer interface [polypeptide binding]; other site 331271001902 Maf-like protein; Region: Maf; pfam02545 331271001903 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 331271001904 active site 331271001905 dimer interface [polypeptide binding]; other site 331271001906 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 331271001907 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 331271001908 putative phosphate acyltransferase; Provisional; Region: PRK05331 331271001909 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 331271001910 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 331271001911 dimer interface [polypeptide binding]; other site 331271001912 active site 331271001913 CoA binding pocket [chemical binding]; other site 331271001914 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 331271001915 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 331271001916 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 331271001917 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 331271001918 NAD(P) binding site [chemical binding]; other site 331271001919 homotetramer interface [polypeptide binding]; other site 331271001920 homodimer interface [polypeptide binding]; other site 331271001921 active site 331271001922 acyl carrier protein; Provisional; Region: acpP; PRK00982 331271001923 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 331271001924 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 331271001925 dimer interface [polypeptide binding]; other site 331271001926 active site 331271001927 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 331271001928 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271001929 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271001930 DNA binding residues [nucleotide binding] 331271001931 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 331271001932 anti-sigma E factor; Provisional; Region: rseB; PRK09455 331271001933 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 331271001934 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 331271001935 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 331271001936 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331271001937 protein binding site [polypeptide binding]; other site 331271001938 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331271001939 protein binding site [polypeptide binding]; other site 331271001940 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 331271001941 GTP-binding protein LepA; Provisional; Region: PRK05433 331271001942 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 331271001943 G1 box; other site 331271001944 putative GEF interaction site [polypeptide binding]; other site 331271001945 GTP/Mg2+ binding site [chemical binding]; other site 331271001946 Switch I region; other site 331271001947 G2 box; other site 331271001948 G3 box; other site 331271001949 Switch II region; other site 331271001950 G4 box; other site 331271001951 G5 box; other site 331271001952 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 331271001953 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 331271001954 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 331271001955 signal peptidase I; Provisional; Region: PRK10861 331271001956 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 331271001957 Catalytic site [active] 331271001958 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 331271001959 ribonuclease III; Reviewed; Region: PRK12372 331271001960 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 331271001961 dimerization interface [polypeptide binding]; other site 331271001962 active site 331271001963 metal binding site [ion binding]; metal-binding site 331271001964 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 331271001965 GTPase Era; Reviewed; Region: era; PRK00089 331271001966 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 331271001967 G1 box; other site 331271001968 GTP/Mg2+ binding site [chemical binding]; other site 331271001969 Switch I region; other site 331271001970 G2 box; other site 331271001971 Switch II region; other site 331271001972 G3 box; other site 331271001973 G4 box; other site 331271001974 G5 box; other site 331271001975 KH domain; Region: KH_2; pfam07650 331271001976 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 331271001977 Recombination protein O N terminal; Region: RecO_N; pfam11967 331271001978 Recombination protein O C terminal; Region: RecO_C; pfam02565 331271001979 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 331271001980 active site 331271001981 hydrophilic channel; other site 331271001982 dimerization interface [polypeptide binding]; other site 331271001983 catalytic residues [active] 331271001984 active site lid [active] 331271001985 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 331271001986 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 331271001987 beta-hexosaminidase; Provisional; Region: PRK05337 331271001988 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331271001989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271001990 active site 331271001991 phosphorylation site [posttranslational modification] 331271001992 intermolecular recognition site; other site 331271001993 dimerization interface [polypeptide binding]; other site 331271001994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271001995 Walker A motif; other site 331271001996 ATP binding site [chemical binding]; other site 331271001997 Walker B motif; other site 331271001998 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271001999 elongation factor P; Validated; Region: PRK00529 331271002000 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 331271002001 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 331271002002 RNA binding site [nucleotide binding]; other site 331271002003 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 331271002004 RNA binding site [nucleotide binding]; other site 331271002005 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 331271002006 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 331271002007 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 331271002008 GIY-YIG motif/motif A; other site 331271002009 active site 331271002010 catalytic site [active] 331271002011 putative DNA binding site [nucleotide binding]; other site 331271002012 metal binding site [ion binding]; metal-binding site 331271002013 UvrB/uvrC motif; Region: UVR; pfam02151 331271002014 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 331271002015 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 331271002016 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271002017 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 331271002018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271002019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271002020 non-specific DNA binding site [nucleotide binding]; other site 331271002021 salt bridge; other site 331271002022 sequence-specific DNA binding site [nucleotide binding]; other site 331271002023 Cupin domain; Region: Cupin_2; cl17218 331271002024 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 331271002025 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 331271002026 active site 331271002027 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 331271002028 LysR family transcriptional regulator; Provisional; Region: PRK14997 331271002029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002030 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 331271002031 putative effector binding pocket; other site 331271002032 putative dimerization interface [polypeptide binding]; other site 331271002033 Pirin-related protein [General function prediction only]; Region: COG1741 331271002034 Pirin; Region: Pirin; pfam02678 331271002035 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 331271002036 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 331271002037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271002038 Coenzyme A binding pocket [chemical binding]; other site 331271002039 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 331271002040 Protein of unknown function (DUF461); Region: DUF461; pfam04314 331271002041 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 331271002042 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 331271002043 Cu(I) binding site [ion binding]; other site 331271002044 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 331271002045 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 331271002046 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 331271002047 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 331271002048 active site 331271002049 homotetramer interface [polypeptide binding]; other site 331271002050 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331271002051 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271002052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271002053 Walker A/P-loop; other site 331271002054 ATP binding site [chemical binding]; other site 331271002055 Q-loop/lid; other site 331271002056 ABC transporter signature motif; other site 331271002057 Walker B; other site 331271002058 D-loop; other site 331271002059 H-loop/switch region; other site 331271002060 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271002061 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 331271002062 putative ADP-binding pocket [chemical binding]; other site 331271002063 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 331271002064 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 331271002065 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 331271002066 active site 331271002067 tetramer interface [polypeptide binding]; other site 331271002068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271002069 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 331271002070 DNA-binding site [nucleotide binding]; DNA binding site 331271002071 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 331271002072 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271002073 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271002074 dimerization interface [polypeptide binding]; other site 331271002075 ligand binding site [chemical binding]; other site 331271002076 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 331271002077 Phosphoesterase family; Region: Phosphoesterase; pfam04185 331271002078 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271002079 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271002080 pyridoxamine kinase; Validated; Region: PRK05756 331271002081 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 331271002082 dimer interface [polypeptide binding]; other site 331271002083 pyridoxal binding site [chemical binding]; other site 331271002084 ATP binding site [chemical binding]; other site 331271002085 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271002086 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271002087 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 331271002088 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 331271002089 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 331271002090 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 331271002091 ligand binding site; other site 331271002092 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 331271002093 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 331271002094 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331271002095 B12 binding site [chemical binding]; other site 331271002096 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271002097 FeS/SAM binding site; other site 331271002098 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 331271002099 putative active site [active] 331271002100 YdjC motif; other site 331271002101 Mg binding site [ion binding]; other site 331271002102 putative homodimer interface [polypeptide binding]; other site 331271002103 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 331271002104 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 331271002105 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271002106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002107 dimer interface [polypeptide binding]; other site 331271002108 conserved gate region; other site 331271002109 putative PBP binding loops; other site 331271002110 ABC-ATPase subunit interface; other site 331271002111 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271002112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002113 dimer interface [polypeptide binding]; other site 331271002114 conserved gate region; other site 331271002115 putative PBP binding loops; other site 331271002116 ABC-ATPase subunit interface; other site 331271002117 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 331271002118 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271002119 Walker A/P-loop; other site 331271002120 ATP binding site [chemical binding]; other site 331271002121 Q-loop/lid; other site 331271002122 ABC transporter signature motif; other site 331271002123 Walker B; other site 331271002124 D-loop; other site 331271002125 H-loop/switch region; other site 331271002126 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271002127 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 331271002128 conserved cys residue [active] 331271002129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271002130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271002131 Transposase, Mutator family; Region: Transposase_mut; pfam00872 331271002132 MULE transposase domain; Region: MULE; pfam10551 331271002133 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 331271002134 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271002135 inhibitor-cofactor binding pocket; inhibition site 331271002136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271002137 catalytic residue [active] 331271002138 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 331271002139 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 331271002140 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 331271002141 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 331271002142 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 331271002143 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 331271002144 NAD(P) binding site [chemical binding]; other site 331271002145 catalytic residues [active] 331271002146 succinylarginine dihydrolase; Provisional; Region: PRK13281 331271002147 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 331271002148 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 331271002149 putative active site [active] 331271002150 Zn binding site [ion binding]; other site 331271002151 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 331271002152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271002153 substrate binding pocket [chemical binding]; other site 331271002154 membrane-bound complex binding site; other site 331271002155 hinge residues; other site 331271002156 HDOD domain; Region: HDOD; pfam08668 331271002157 PAS domain; Region: PAS_9; pfam13426 331271002158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271002159 putative active site [active] 331271002160 heme pocket [chemical binding]; other site 331271002161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271002162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271002163 metal binding site [ion binding]; metal-binding site 331271002164 active site 331271002165 I-site; other site 331271002166 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271002167 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 331271002168 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271002169 catalytic triad [active] 331271002170 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331271002171 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331271002172 NAD(P) binding site [chemical binding]; other site 331271002173 putative active site [active] 331271002174 Probable transposase; Region: OrfB_IS605; pfam01385 331271002175 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271002176 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271002177 NYN domain; Region: NYN; pfam01936 331271002178 putative metal binding site [ion binding]; other site 331271002179 Uncharacterized conserved protein [Function unknown]; Region: COG1432 331271002180 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 331271002181 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331271002182 active site 331271002183 metal binding site [ion binding]; metal-binding site 331271002184 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271002185 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271002186 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 331271002187 Protein export membrane protein; Region: SecD_SecF; cl14618 331271002188 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 331271002189 Protein export membrane protein; Region: SecD_SecF; cl14618 331271002190 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271002191 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271002192 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271002193 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271002194 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271002195 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271002196 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 331271002197 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 331271002198 Predicted transcriptional regulator [Transcription]; Region: COG1959 331271002199 Transcriptional regulator; Region: Rrf2; pfam02082 331271002200 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 331271002201 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331271002202 NAD binding site [chemical binding]; other site 331271002203 putative active site [active] 331271002204 substrate binding site [chemical binding]; other site 331271002205 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271002206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271002207 putative DNA binding site [nucleotide binding]; other site 331271002208 putative Zn2+ binding site [ion binding]; other site 331271002209 AsnC family; Region: AsnC_trans_reg; pfam01037 331271002210 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 331271002211 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 331271002212 Walker A/P-loop; other site 331271002213 ATP binding site [chemical binding]; other site 331271002214 Q-loop/lid; other site 331271002215 ABC transporter signature motif; other site 331271002216 Walker B; other site 331271002217 D-loop; other site 331271002218 H-loop/switch region; other site 331271002219 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 331271002220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002221 dimer interface [polypeptide binding]; other site 331271002222 conserved gate region; other site 331271002223 putative PBP binding loops; other site 331271002224 ABC-ATPase subunit interface; other site 331271002225 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 331271002226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002227 dimer interface [polypeptide binding]; other site 331271002228 conserved gate region; other site 331271002229 putative PBP binding loops; other site 331271002230 ABC-ATPase subunit interface; other site 331271002231 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 331271002232 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271002233 putative proline-specific permease; Provisional; Region: proY; PRK10580 331271002234 Spore germination protein; Region: Spore_permease; cl17796 331271002235 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 331271002236 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 331271002237 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 331271002238 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 331271002239 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 331271002240 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 331271002241 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 331271002242 Family description; Region: UvrD_C_2; pfam13538 331271002243 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 331271002244 AAA domain; Region: AAA_30; pfam13604 331271002245 Family description; Region: UvrD_C_2; pfam13538 331271002246 hypothetical protein; Provisional; Region: PRK09256 331271002247 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 331271002248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271002249 EamA-like transporter family; Region: EamA; pfam00892 331271002250 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 331271002251 EamA-like transporter family; Region: EamA; pfam00892 331271002252 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 331271002253 ThiC-associated domain; Region: ThiC-associated; pfam13667 331271002254 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 331271002255 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 331271002256 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 331271002257 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 331271002258 Moco binding site; other site 331271002259 metal coordination site [ion binding]; other site 331271002260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271002261 non-specific DNA binding site [nucleotide binding]; other site 331271002262 salt bridge; other site 331271002263 sequence-specific DNA binding site [nucleotide binding]; other site 331271002264 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 331271002265 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 331271002266 EamA-like transporter family; Region: EamA; pfam00892 331271002267 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271002268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271002269 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 331271002270 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331271002271 active site 331271002272 metal binding site [ion binding]; metal-binding site 331271002273 hexamer interface [polypeptide binding]; other site 331271002274 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 331271002275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271002276 Walker A/P-loop; other site 331271002277 ATP binding site [chemical binding]; other site 331271002278 Q-loop/lid; other site 331271002279 ABC transporter signature motif; other site 331271002280 Walker B; other site 331271002281 D-loop; other site 331271002282 H-loop/switch region; other site 331271002283 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271002284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002285 dimer interface [polypeptide binding]; other site 331271002286 conserved gate region; other site 331271002287 putative PBP binding loops; other site 331271002288 ABC-ATPase subunit interface; other site 331271002289 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 331271002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002291 dimer interface [polypeptide binding]; other site 331271002292 conserved gate region; other site 331271002293 ABC-ATPase subunit interface; other site 331271002294 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271002295 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 331271002296 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271002297 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271002298 DNA binding site [nucleotide binding] 331271002299 domain linker motif; other site 331271002300 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 331271002301 putative dimerization interface [polypeptide binding]; other site 331271002302 putative ligand binding site [chemical binding]; other site 331271002303 oxidoreductase; Provisional; Region: PRK06128 331271002304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271002305 NAD(P) binding site [chemical binding]; other site 331271002306 active site 331271002307 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271002308 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 331271002309 NAD(P) binding site [chemical binding]; other site 331271002310 DoxX; Region: DoxX; pfam07681 331271002311 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271002312 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331271002313 FMN binding site [chemical binding]; other site 331271002314 active site 331271002315 substrate binding site [chemical binding]; other site 331271002316 catalytic residue [active] 331271002317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002319 LysR substrate binding domain; Region: LysR_substrate; pfam03466 331271002320 dimerization interface [polypeptide binding]; other site 331271002321 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 331271002322 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 331271002323 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 331271002324 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 331271002325 tetramer interface [polypeptide binding]; other site 331271002326 TPP-binding site [chemical binding]; other site 331271002327 heterodimer interface [polypeptide binding]; other site 331271002328 phosphorylation loop region [posttranslational modification] 331271002329 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 331271002330 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 331271002331 alpha subunit interface [polypeptide binding]; other site 331271002332 TPP binding site [chemical binding]; other site 331271002333 heterodimer interface [polypeptide binding]; other site 331271002334 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331271002335 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 331271002336 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271002337 E3 interaction surface; other site 331271002338 lipoyl attachment site [posttranslational modification]; other site 331271002339 e3 binding domain; Region: E3_binding; pfam02817 331271002340 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 331271002341 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 331271002342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271002343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271002344 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331271002345 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 331271002346 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 331271002347 NAD binding site [chemical binding]; other site 331271002348 active site 331271002349 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 331271002350 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 331271002351 Na binding site [ion binding]; other site 331271002352 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271002353 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271002354 trimer interface [polypeptide binding]; other site 331271002355 eyelet of channel; other site 331271002356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002358 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271002359 dimerization interface [polypeptide binding]; other site 331271002360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271002361 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271002362 putative substrate translocation pore; other site 331271002363 allantoate amidohydrolase; Reviewed; Region: PRK12893 331271002364 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 331271002365 active site 331271002366 metal binding site [ion binding]; metal-binding site 331271002367 dimer interface [polypeptide binding]; other site 331271002368 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 331271002369 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 331271002370 active site 331271002371 Zn binding site [ion binding]; other site 331271002372 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271002373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271002374 putative substrate translocation pore; other site 331271002375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002377 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 331271002378 dimerization interface [polypeptide binding]; other site 331271002379 substrate binding pocket [chemical binding]; other site 331271002380 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 331271002381 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 331271002382 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271002383 catalytic residue [active] 331271002384 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 331271002385 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 331271002386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002387 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271002388 dimerization interface [polypeptide binding]; other site 331271002389 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 331271002390 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 331271002391 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 331271002392 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331271002393 putative dimer interface [polypeptide binding]; other site 331271002394 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 331271002395 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331271002396 putative dimer interface [polypeptide binding]; other site 331271002397 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 331271002398 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271002399 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271002400 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271002401 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 331271002402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002403 LysR substrate binding domain; Region: LysR_substrate; pfam03466 331271002404 dimerization interface [polypeptide binding]; other site 331271002405 Malonate transporter MadL subunit; Region: MadL; cl04273 331271002406 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 331271002407 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 331271002408 Coenzyme A transferase; Region: CoA_trans; cl17247 331271002409 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 331271002410 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 331271002411 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 331271002412 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 331271002413 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 331271002414 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 331271002415 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 331271002416 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 331271002417 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271002418 putative active site [active] 331271002419 catalytic site [active] 331271002420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271002421 active site 331271002422 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 331271002423 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 331271002424 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271002425 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 331271002426 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 331271002427 N-terminal domain interface [polypeptide binding]; other site 331271002428 dimer interface [polypeptide binding]; other site 331271002429 substrate binding pocket (H-site) [chemical binding]; other site 331271002430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271002431 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271002432 putative substrate translocation pore; other site 331271002433 hypothetical protein; Provisional; Region: PRK02237 331271002434 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 331271002435 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 331271002436 active site 331271002437 catalytic site [active] 331271002438 substrate binding site [chemical binding]; other site 331271002439 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 331271002440 RNA/DNA hybrid binding site [nucleotide binding]; other site 331271002441 active site 331271002442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271002443 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 331271002444 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 331271002445 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271002446 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271002447 catalytic residue [active] 331271002448 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 331271002449 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331271002450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271002451 D-galactonate transporter; Region: 2A0114; TIGR00893 331271002452 putative substrate translocation pore; other site 331271002453 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 331271002454 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 331271002455 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 331271002456 catalytic site [active] 331271002457 subunit interface [polypeptide binding]; other site 331271002458 leucine export protein LeuE; Provisional; Region: PRK10958 331271002459 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 331271002460 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331271002461 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 331271002462 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 331271002463 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331271002464 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331271002465 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 331271002466 IMP binding site; other site 331271002467 dimer interface [polypeptide binding]; other site 331271002468 interdomain contacts; other site 331271002469 partial ornithine binding site; other site 331271002470 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 331271002471 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 331271002472 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 331271002473 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 331271002474 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 331271002475 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 331271002476 FtsJ-like methyltransferase; Region: FtsJ; cl17430 331271002477 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 331271002478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271002479 Walker A motif; other site 331271002480 ATP binding site [chemical binding]; other site 331271002481 Walker B motif; other site 331271002482 arginine finger; other site 331271002483 Peptidase family M41; Region: Peptidase_M41; pfam01434 331271002484 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 331271002485 dihydropteroate synthase; Region: DHPS; TIGR01496 331271002486 substrate binding pocket [chemical binding]; other site 331271002487 dimer interface [polypeptide binding]; other site 331271002488 inhibitor binding site; inhibition site 331271002489 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 331271002490 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 331271002491 active site 331271002492 substrate binding site [chemical binding]; other site 331271002493 metal binding site [ion binding]; metal-binding site 331271002494 PBP superfamily domain; Region: PBP_like_2; cl17296 331271002495 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 331271002496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002497 dimer interface [polypeptide binding]; other site 331271002498 conserved gate region; other site 331271002499 putative PBP binding loops; other site 331271002500 ABC-ATPase subunit interface; other site 331271002501 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 331271002502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271002503 dimer interface [polypeptide binding]; other site 331271002504 conserved gate region; other site 331271002505 putative PBP binding loops; other site 331271002506 ABC-ATPase subunit interface; other site 331271002507 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 331271002508 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 331271002509 Walker A/P-loop; other site 331271002510 ATP binding site [chemical binding]; other site 331271002511 Q-loop/lid; other site 331271002512 ABC transporter signature motif; other site 331271002513 Walker B; other site 331271002514 D-loop; other site 331271002515 H-loop/switch region; other site 331271002516 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 331271002517 PhoU domain; Region: PhoU; pfam01895 331271002518 PhoU domain; Region: PhoU; pfam01895 331271002519 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 331271002520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271002521 active site 331271002522 phosphorylation site [posttranslational modification] 331271002523 intermolecular recognition site; other site 331271002524 dimerization interface [polypeptide binding]; other site 331271002525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271002526 DNA binding site [nucleotide binding] 331271002527 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 331271002528 PAS domain; Region: PAS; smart00091 331271002529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271002530 dimer interface [polypeptide binding]; other site 331271002531 phosphorylation site [posttranslational modification] 331271002532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271002533 ATP binding site [chemical binding]; other site 331271002534 Mg2+ binding site [ion binding]; other site 331271002535 G-X-G motif; other site 331271002536 polyphosphate kinase; Provisional; Region: PRK05443 331271002537 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 331271002538 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 331271002539 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 331271002540 putative domain interface [polypeptide binding]; other site 331271002541 putative active site [active] 331271002542 catalytic site [active] 331271002543 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271002544 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 331271002545 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 331271002546 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331271002547 catalytic core [active] 331271002548 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 331271002549 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 331271002550 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 331271002551 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 331271002552 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 331271002553 active site 331271002554 acyl-activating enzyme (AAE) consensus motif; other site 331271002555 putative CoA binding site [chemical binding]; other site 331271002556 AMP binding site [chemical binding]; other site 331271002557 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331271002558 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 331271002559 Peptidase family M23; Region: Peptidase_M23; pfam01551 331271002560 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 331271002561 active site 331271002562 catalytic residues [active] 331271002563 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 331271002564 Phage terminase, small subunit; Region: Terminase_4; pfam05119 331271002565 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 331271002566 synthetase active site [active] 331271002567 NTP binding site [chemical binding]; other site 331271002568 metal binding site [ion binding]; metal-binding site 331271002569 hypothetical protein; Provisional; Region: PRK14709 331271002570 D5 N terminal like; Region: D5_N; smart00885 331271002571 CHC2 zinc finger; Region: zf-CHC2; cl17510 331271002572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331271002573 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 331271002574 active site 331271002575 DNA binding site [nucleotide binding] 331271002576 Int/Topo IB signature motif; other site 331271002577 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331271002578 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331271002579 glutaminase active site [active] 331271002580 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331271002581 dimer interface [polypeptide binding]; other site 331271002582 active site 331271002583 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331271002584 dimer interface [polypeptide binding]; other site 331271002585 active site 331271002586 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926 331271002587 putative active site [active] 331271002588 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 331271002589 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331271002590 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 331271002591 DXD motif; other site 331271002592 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 331271002593 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 331271002594 active site 331271002595 homodimer interface [polypeptide binding]; other site 331271002596 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 331271002597 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271002598 putative NAD(P) binding site [chemical binding]; other site 331271002599 substrate binding site [chemical binding]; other site 331271002600 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 331271002601 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271002602 catalytic loop [active] 331271002603 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 331271002604 iron binding site [ion binding]; other site 331271002605 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271002606 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271002607 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271002608 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271002609 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271002610 aldolase II superfamily protein; Provisional; Region: PRK07044 331271002611 intersubunit interface [polypeptide binding]; other site 331271002612 active site 331271002613 Zn2+ binding site [ion binding]; other site 331271002614 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 331271002615 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 331271002616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271002617 active site 331271002618 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 331271002619 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271002620 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 331271002621 NAD(P) binding site [chemical binding]; other site 331271002622 Predicted transcriptional regulators [Transcription]; Region: COG1695 331271002623 Transcriptional regulator PadR-like family; Region: PadR; cl17335 331271002624 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 331271002625 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271002626 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 331271002627 active site 331271002628 FMN binding site [chemical binding]; other site 331271002629 2,4-decadienoyl-CoA binding site; other site 331271002630 catalytic residue [active] 331271002631 4Fe-4S cluster binding site [ion binding]; other site 331271002632 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 331271002633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271002634 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271002635 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271002636 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271002637 N-terminal plug; other site 331271002638 ligand-binding site [chemical binding]; other site 331271002639 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 331271002640 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 331271002641 Walker A/P-loop; other site 331271002642 ATP binding site [chemical binding]; other site 331271002643 Q-loop/lid; other site 331271002644 ABC transporter signature motif; other site 331271002645 Walker B; other site 331271002646 D-loop; other site 331271002647 H-loop/switch region; other site 331271002648 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 331271002649 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 331271002650 putative ligand binding residues [chemical binding]; other site 331271002651 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 331271002652 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331271002653 ABC-ATPase subunit interface; other site 331271002654 dimer interface [polypeptide binding]; other site 331271002655 putative PBP binding regions; other site 331271002656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271002657 dimerization interface [polypeptide binding]; other site 331271002658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271002659 dimer interface [polypeptide binding]; other site 331271002660 phosphorylation site [posttranslational modification] 331271002661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271002662 ATP binding site [chemical binding]; other site 331271002663 Mg2+ binding site [ion binding]; other site 331271002664 G-X-G motif; other site 331271002665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271002666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271002667 active site 331271002668 phosphorylation site [posttranslational modification] 331271002669 intermolecular recognition site; other site 331271002670 dimerization interface [polypeptide binding]; other site 331271002671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271002672 DNA binding site [nucleotide binding] 331271002673 MltA-interacting protein MipA; Region: MipA; cl01504 331271002674 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 331271002675 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271002676 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271002677 catalytic residue [active] 331271002678 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 331271002679 VirB7 interaction site; other site 331271002680 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271002681 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271002682 trimer interface [polypeptide binding]; other site 331271002683 eyelet of channel; other site 331271002684 RNA polymerase sigma factor; Provisional; Region: PRK12528 331271002685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271002686 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271002687 DNA binding residues [nucleotide binding] 331271002688 fec operon regulator FecR; Reviewed; Region: PRK09774 331271002689 FecR protein; Region: FecR; pfam04773 331271002690 Secretin and TonB N terminus short domain; Region: STN; smart00965 331271002691 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271002692 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271002693 N-terminal plug; other site 331271002694 ligand-binding site [chemical binding]; other site 331271002695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002697 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 331271002698 putative dimerization interface [polypeptide binding]; other site 331271002699 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 331271002700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271002701 putative metal binding site [ion binding]; other site 331271002702 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 331271002703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002705 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 331271002706 putative dimerization interface [polypeptide binding]; other site 331271002707 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 331271002708 Citrate transporter; Region: CitMHS; pfam03600 331271002709 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 331271002710 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 331271002711 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 331271002712 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331271002713 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331271002714 putative acyl-acceptor binding pocket; other site 331271002715 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 331271002716 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 331271002717 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271002718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271002719 S-adenosylmethionine binding site [chemical binding]; other site 331271002720 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 331271002721 active site 331271002722 GAF domain; Region: GAF_2; pfam13185 331271002723 GAF domain; Region: GAF_3; pfam13492 331271002724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271002725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271002726 metal binding site [ion binding]; metal-binding site 331271002727 active site 331271002728 I-site; other site 331271002729 cellulose synthase regulator protein; Provisional; Region: PRK11114 331271002730 endo-1,4-D-glucanase; Provisional; Region: PRK11097 331271002731 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 331271002732 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331271002733 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 331271002734 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 331271002735 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 331271002736 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 331271002737 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 331271002738 DXD motif; other site 331271002739 PilZ domain; Region: PilZ; pfam07238 331271002740 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 331271002741 Pirin-related protein [General function prediction only]; Region: COG1741 331271002742 Pirin; Region: Pirin; pfam02678 331271002743 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 331271002744 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 331271002745 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 331271002746 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 331271002747 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 331271002748 Isochorismatase family; Region: Isochorismatase; pfam00857 331271002749 catalytic triad [active] 331271002750 dimer interface [polypeptide binding]; other site 331271002751 conserved cis-peptide bond; other site 331271002752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002754 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271002755 putative effector binding pocket; other site 331271002756 dimerization interface [polypeptide binding]; other site 331271002757 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 331271002758 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 331271002759 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 331271002760 active site 331271002761 Predicted membrane protein [Function unknown]; Region: COG2259 331271002762 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331271002763 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 331271002764 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 331271002765 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 331271002766 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 331271002767 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 331271002768 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 331271002769 nudix motif; other site 331271002770 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 331271002771 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331271002772 active site 331271002773 HIGH motif; other site 331271002774 nucleotide binding site [chemical binding]; other site 331271002775 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331271002776 active site 331271002777 KMSKS motif; other site 331271002778 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 331271002779 Serine hydrolase; Region: Ser_hydrolase; pfam06821 331271002780 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271002781 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271002782 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 331271002783 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 331271002784 motif 1; other site 331271002785 active site 331271002786 motif 2; other site 331271002787 motif 3; other site 331271002788 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 331271002789 DHHA1 domain; Region: DHHA1; pfam02272 331271002790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271002793 dimerization interface [polypeptide binding]; other site 331271002794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271002795 putative substrate translocation pore; other site 331271002796 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 331271002797 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 331271002798 nudix motif; other site 331271002799 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 331271002800 active site 331271002801 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271002802 TM-ABC transporter signature motif; other site 331271002803 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271002804 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331271002805 TM-ABC transporter signature motif; other site 331271002806 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331271002807 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271002808 Walker A/P-loop; other site 331271002809 ATP binding site [chemical binding]; other site 331271002810 Q-loop/lid; other site 331271002811 ABC transporter signature motif; other site 331271002812 Walker B; other site 331271002813 D-loop; other site 331271002814 H-loop/switch region; other site 331271002815 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331271002816 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271002817 Walker A/P-loop; other site 331271002818 ATP binding site [chemical binding]; other site 331271002819 Q-loop/lid; other site 331271002820 ABC transporter signature motif; other site 331271002821 Walker B; other site 331271002822 D-loop; other site 331271002823 H-loop/switch region; other site 331271002824 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 331271002825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271002826 NAD(P) binding site [chemical binding]; other site 331271002827 active site 331271002828 hypothetical protein; Provisional; Region: PRK02487 331271002829 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 331271002830 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 331271002831 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 331271002832 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271002833 dimer interface [polypeptide binding]; other site 331271002834 PYR/PP interface [polypeptide binding]; other site 331271002835 TPP binding site [chemical binding]; other site 331271002836 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271002837 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 331271002838 TPP-binding site [chemical binding]; other site 331271002839 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271002840 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 331271002841 substrate binding site [chemical binding]; other site 331271002842 ATP binding site [chemical binding]; other site 331271002843 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 331271002844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 331271002845 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 331271002846 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271002847 putative ligand binding site [chemical binding]; other site 331271002848 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271002849 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271002850 Walker A/P-loop; other site 331271002851 ATP binding site [chemical binding]; other site 331271002852 Q-loop/lid; other site 331271002853 ABC transporter signature motif; other site 331271002854 Walker B; other site 331271002855 D-loop; other site 331271002856 H-loop/switch region; other site 331271002857 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271002858 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271002859 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271002860 TM-ABC transporter signature motif; other site 331271002861 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 331271002862 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 331271002863 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 331271002864 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 331271002865 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 331271002866 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 331271002867 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 331271002868 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 331271002869 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 331271002870 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271002871 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 331271002872 putative active site [active] 331271002873 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 331271002874 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 331271002875 tetrameric interface [polypeptide binding]; other site 331271002876 NAD binding site [chemical binding]; other site 331271002877 catalytic residues [active] 331271002878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002880 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271002881 putative effector binding pocket; other site 331271002882 dimerization interface [polypeptide binding]; other site 331271002883 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 331271002884 CPxP motif; other site 331271002885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271002886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271002887 active site 331271002888 phosphorylation site [posttranslational modification] 331271002889 intermolecular recognition site; other site 331271002890 dimerization interface [polypeptide binding]; other site 331271002891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271002892 DNA binding site [nucleotide binding] 331271002893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 331271002894 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331271002895 FecR protein; Region: FecR; pfam04773 331271002896 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 331271002897 CHASE2 domain; Region: CHASE2; pfam05226 331271002898 PAS domain; Region: PAS_9; pfam13426 331271002899 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271002900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271002901 dimer interface [polypeptide binding]; other site 331271002902 phosphorylation site [posttranslational modification] 331271002903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271002904 ATP binding site [chemical binding]; other site 331271002905 Mg2+ binding site [ion binding]; other site 331271002906 G-X-G motif; other site 331271002907 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 331271002908 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 331271002909 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 331271002910 active site 331271002911 tetramer interface; other site 331271002912 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 331271002913 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 331271002914 HIGH motif; other site 331271002915 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331271002916 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 331271002917 active site 331271002918 KMSKS motif; other site 331271002919 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 331271002920 tRNA binding surface [nucleotide binding]; other site 331271002921 anticodon binding site; other site 331271002922 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 331271002923 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 331271002924 Part of AAA domain; Region: AAA_19; pfam13245 331271002925 Family description; Region: UvrD_C_2; pfam13538 331271002926 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 331271002927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271002928 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271002929 putative substrate translocation pore; other site 331271002930 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271002931 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271002932 dimer interface [polypeptide binding]; other site 331271002933 putative CheW interface [polypeptide binding]; other site 331271002934 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 331271002935 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271002936 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271002937 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 331271002938 Fusaric acid resistance protein family; Region: FUSC; pfam04632 331271002939 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 331271002940 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271002941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271002942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002943 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271002944 putative effector binding pocket; other site 331271002945 dimerization interface [polypeptide binding]; other site 331271002946 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 331271002947 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 331271002948 putative active site [active] 331271002949 putative metal binding site [ion binding]; other site 331271002950 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331271002951 FAD binding domain; Region: FAD_binding_4; pfam01565 331271002952 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 331271002953 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 331271002954 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271002955 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 331271002956 Protein of unknown function (DUF962); Region: DUF962; cl01879 331271002957 FOG: CBS domain [General function prediction only]; Region: COG0517 331271002958 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 331271002959 H+ Antiporter protein; Region: 2A0121; TIGR00900 331271002960 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331271002961 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331271002962 putative acyl-acceptor binding pocket; other site 331271002963 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 331271002964 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 331271002965 Tetramer interface [polypeptide binding]; other site 331271002966 active site 331271002967 FMN-binding site [chemical binding]; other site 331271002968 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 331271002969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271002970 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 331271002971 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 331271002972 short chain dehydrogenase; Provisional; Region: PRK06949 331271002973 classical (c) SDRs; Region: SDR_c; cd05233 331271002974 NAD(P) binding site [chemical binding]; other site 331271002975 active site 331271002976 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 331271002977 active site 331271002978 PAS domain; Region: PAS_9; pfam13426 331271002979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271002980 putative active site [active] 331271002981 heme pocket [chemical binding]; other site 331271002982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271002983 DNA binding residues [nucleotide binding] 331271002984 dimerization interface [polypeptide binding]; other site 331271002985 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 331271002986 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 331271002987 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 331271002988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271002989 NAD(P) binding site [chemical binding]; other site 331271002990 active site 331271002991 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 331271002992 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 331271002993 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 331271002994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271002995 transcriptional activator TtdR; Provisional; Region: PRK09801 331271002996 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271002997 putative effector binding pocket; other site 331271002998 dimerization interface [polypeptide binding]; other site 331271002999 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271003000 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271003001 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 331271003002 homotrimer interaction site [polypeptide binding]; other site 331271003003 putative active site [active] 331271003004 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 331271003005 HD domain; Region: HD_4; pfam13328 331271003006 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 331271003007 synthetase active site [active] 331271003008 NTP binding site [chemical binding]; other site 331271003009 metal binding site [ion binding]; metal-binding site 331271003010 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 331271003011 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 331271003012 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 331271003013 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 331271003014 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 331271003015 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 331271003016 active site 331271003017 dimer interface [polypeptide binding]; other site 331271003018 motif 1; other site 331271003019 motif 2; other site 331271003020 motif 3; other site 331271003021 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 331271003022 anticodon binding site; other site 331271003023 translation initiation factor IF-3; Region: infC; TIGR00168 331271003024 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 331271003025 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 331271003026 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 331271003027 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 331271003028 23S rRNA binding site [nucleotide binding]; other site 331271003029 L21 binding site [polypeptide binding]; other site 331271003030 L13 binding site [polypeptide binding]; other site 331271003031 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 331271003032 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 331271003033 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 331271003034 dimer interface [polypeptide binding]; other site 331271003035 motif 1; other site 331271003036 active site 331271003037 motif 2; other site 331271003038 motif 3; other site 331271003039 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 331271003040 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 331271003041 putative tRNA-binding site [nucleotide binding]; other site 331271003042 B3/4 domain; Region: B3_4; pfam03483 331271003043 tRNA synthetase B5 domain; Region: B5; smart00874 331271003044 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 331271003045 dimer interface [polypeptide binding]; other site 331271003046 motif 1; other site 331271003047 motif 3; other site 331271003048 motif 2; other site 331271003049 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 331271003050 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331271003051 IHF dimer interface [polypeptide binding]; other site 331271003052 IHF - DNA interface [nucleotide binding]; other site 331271003053 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 331271003054 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 331271003055 DNA binding residues [nucleotide binding] 331271003056 Methyltransferase domain; Region: Methyltransf_23; pfam13489 331271003057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331271003058 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 331271003059 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 331271003060 Uncharacterized conserved protein [Function unknown]; Region: COG1359 331271003061 Uncharacterized conserved protein [Function unknown]; Region: COG1434 331271003062 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 331271003063 putative active site [active] 331271003064 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 331271003065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271003066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271003067 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 331271003068 putative dimerization interface [polypeptide binding]; other site 331271003069 aspartate aminotransferase; Provisional; Region: PRK06108 331271003070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271003071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271003072 homodimer interface [polypeptide binding]; other site 331271003073 catalytic residue [active] 331271003074 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 331271003075 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 331271003076 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331271003077 RNA binding surface [nucleotide binding]; other site 331271003078 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 331271003079 probable active site [active] 331271003080 ribosome maturation protein RimP; Reviewed; Region: PRK00092 331271003081 Sm and related proteins; Region: Sm_like; cl00259 331271003082 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 331271003083 putative oligomer interface [polypeptide binding]; other site 331271003084 putative RNA binding site [nucleotide binding]; other site 331271003085 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 331271003086 NusA N-terminal domain; Region: NusA_N; pfam08529 331271003087 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 331271003088 RNA binding site [nucleotide binding]; other site 331271003089 homodimer interface [polypeptide binding]; other site 331271003090 NusA-like KH domain; Region: KH_5; pfam13184 331271003091 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 331271003092 G-X-X-G motif; other site 331271003093 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 331271003094 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 331271003095 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 331271003096 translation initiation factor IF-2; Region: IF-2; TIGR00487 331271003097 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 331271003098 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 331271003099 G1 box; other site 331271003100 putative GEF interaction site [polypeptide binding]; other site 331271003101 GTP/Mg2+ binding site [chemical binding]; other site 331271003102 Switch I region; other site 331271003103 G2 box; other site 331271003104 G3 box; other site 331271003105 Switch II region; other site 331271003106 G4 box; other site 331271003107 G5 box; other site 331271003108 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 331271003109 Translation-initiation factor 2; Region: IF-2; pfam11987 331271003110 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 331271003111 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 331271003112 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 331271003113 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 331271003114 RNA binding site [nucleotide binding]; other site 331271003115 active site 331271003116 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 331271003117 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271003118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003119 putative substrate translocation pore; other site 331271003120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003121 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 331271003122 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271003123 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271003124 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271003125 MarR family; Region: MarR_2; cl17246 331271003126 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 331271003127 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 331271003128 G1 box; other site 331271003129 putative GEF interaction site [polypeptide binding]; other site 331271003130 GTP/Mg2+ binding site [chemical binding]; other site 331271003131 Switch I region; other site 331271003132 G2 box; other site 331271003133 G3 box; other site 331271003134 Switch II region; other site 331271003135 G4 box; other site 331271003136 G5 box; other site 331271003137 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 331271003138 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 331271003139 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 331271003140 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 331271003141 TPP-binding site [chemical binding]; other site 331271003142 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 331271003143 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271003144 E3 interaction surface; other site 331271003145 lipoyl attachment site [posttranslational modification]; other site 331271003146 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 331271003147 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 331271003148 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 331271003149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271003150 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331271003151 Predicted ATPase [General function prediction only]; Region: COG1485 331271003152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271003153 Walker B; other site 331271003154 D-loop; other site 331271003155 H-loop/switch region; other site 331271003156 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 331271003157 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 331271003158 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 331271003159 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 331271003160 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 331271003161 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 331271003162 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 331271003163 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 331271003164 TadE-like protein; Region: TadE; pfam07811 331271003165 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 331271003166 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 331271003167 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 331271003168 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 331271003169 AAA domain; Region: AAA_31; pfam13614 331271003170 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 331271003171 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 331271003172 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 331271003173 ATP binding site [chemical binding]; other site 331271003174 Walker A motif; other site 331271003175 hexamer interface [polypeptide binding]; other site 331271003176 Walker B motif; other site 331271003177 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 331271003178 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271003179 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 331271003180 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271003181 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 331271003182 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 331271003183 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 331271003184 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 331271003185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271003186 Walker A motif; other site 331271003187 ATP binding site [chemical binding]; other site 331271003188 Walker B motif; other site 331271003189 arginine finger; other site 331271003190 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271003191 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 331271003192 bacterial Hfq-like; Region: Hfq; cd01716 331271003193 hexamer interface [polypeptide binding]; other site 331271003194 Sm1 motif; other site 331271003195 RNA binding site [nucleotide binding]; other site 331271003196 Sm2 motif; other site 331271003197 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 331271003198 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 331271003199 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 331271003200 acyl-activating enzyme (AAE) consensus motif; other site 331271003201 putative AMP binding site [chemical binding]; other site 331271003202 putative active site [active] 331271003203 putative CoA binding site [chemical binding]; other site 331271003204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271003205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271003206 putative sialic acid transporter; Region: 2A0112; TIGR00891 331271003207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003208 putative substrate translocation pore; other site 331271003209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271003210 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271003211 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 331271003212 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 331271003213 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 331271003214 Sulfate transporter family; Region: Sulfate_transp; pfam00916 331271003215 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 331271003216 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 331271003217 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271003218 putative substrate binding site [chemical binding]; other site 331271003219 putative ATP binding site [chemical binding]; other site 331271003220 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 331271003221 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271003222 putative ligand binding site [chemical binding]; other site 331271003223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271003224 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271003225 TM-ABC transporter signature motif; other site 331271003226 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271003227 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271003228 Walker A/P-loop; other site 331271003229 ATP binding site [chemical binding]; other site 331271003230 Q-loop/lid; other site 331271003231 ABC transporter signature motif; other site 331271003232 Walker B; other site 331271003233 D-loop; other site 331271003234 H-loop/switch region; other site 331271003235 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271003236 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 331271003237 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 331271003238 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 331271003239 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271003240 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271003241 substrate binding pocket [chemical binding]; other site 331271003242 membrane-bound complex binding site; other site 331271003243 hinge residues; other site 331271003244 ribonuclease R; Region: RNase_R; TIGR02063 331271003245 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 331271003246 RNB domain; Region: RNB; pfam00773 331271003247 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 331271003248 RNA binding site [nucleotide binding]; other site 331271003249 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 331271003250 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 331271003251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 331271003252 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 331271003253 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 331271003254 amidase catalytic site [active] 331271003255 Zn binding residues [ion binding]; other site 331271003256 substrate binding site [chemical binding]; other site 331271003257 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 331271003258 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 331271003259 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331271003260 active site 331271003261 dimer interface [polypeptide binding]; other site 331271003262 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271003263 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271003264 DNA-binding site [nucleotide binding]; DNA binding site 331271003265 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 331271003266 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 331271003267 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 331271003268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003269 dimer interface [polypeptide binding]; other site 331271003270 conserved gate region; other site 331271003271 putative PBP binding loops; other site 331271003272 ABC-ATPase subunit interface; other site 331271003273 cystine transporter subunit; Provisional; Region: PRK11260 331271003274 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271003275 substrate binding pocket [chemical binding]; other site 331271003276 membrane-bound complex binding site; other site 331271003277 hinge residues; other site 331271003278 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 331271003279 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 331271003280 quinone interaction residues [chemical binding]; other site 331271003281 active site 331271003282 catalytic residues [active] 331271003283 FMN binding site [chemical binding]; other site 331271003284 substrate binding site [chemical binding]; other site 331271003285 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 331271003286 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 331271003287 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 331271003288 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 331271003289 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 331271003290 nudix motif; other site 331271003291 hypothetical protein; Provisional; Region: PRK02487 331271003292 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 331271003293 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 331271003294 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271003295 substrate binding site [chemical binding]; other site 331271003296 oxyanion hole (OAH) forming residues; other site 331271003297 trimer interface [polypeptide binding]; other site 331271003298 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 331271003299 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 331271003300 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 331271003301 active site 331271003302 dimer interface [polypeptide binding]; other site 331271003303 non-prolyl cis peptide bond; other site 331271003304 insertion regions; other site 331271003305 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271003306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003307 dimer interface [polypeptide binding]; other site 331271003308 conserved gate region; other site 331271003309 putative PBP binding loops; other site 331271003310 ABC-ATPase subunit interface; other site 331271003311 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 331271003312 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271003313 Walker A/P-loop; other site 331271003314 ATP binding site [chemical binding]; other site 331271003315 Q-loop/lid; other site 331271003316 ABC transporter signature motif; other site 331271003317 Walker B; other site 331271003318 D-loop; other site 331271003319 H-loop/switch region; other site 331271003320 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 331271003321 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 331271003322 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 331271003323 FMN binding site [chemical binding]; other site 331271003324 active site 331271003325 catalytic residues [active] 331271003326 substrate binding site [chemical binding]; other site 331271003327 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331271003328 active site 331271003329 Int/Topo IB signature motif; other site 331271003330 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 331271003331 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 331271003332 dimerization interface [polypeptide binding]; other site 331271003333 mannose binding site [chemical binding]; other site 331271003334 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 331271003335 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 331271003336 dimerization interface [polypeptide binding]; other site 331271003337 mannose binding site [chemical binding]; other site 331271003338 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 331271003339 dimerization interface [polypeptide binding]; other site 331271003340 D-mannose binding lectin; Region: B_lectin; pfam01453 331271003341 mannose binding site [chemical binding]; other site 331271003342 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 331271003343 dimerization interface [polypeptide binding]; other site 331271003344 D-mannose binding lectin; Region: B_lectin; pfam01453 331271003345 mannose binding site [chemical binding]; other site 331271003346 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 331271003347 Methyltransferase domain; Region: Methyltransf_23; pfam13489 331271003348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271003349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271003350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271003351 Coenzyme A binding pocket [chemical binding]; other site 331271003352 Family of unknown function (DUF695); Region: DUF695; pfam05117 331271003353 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 331271003354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 331271003355 putative dimer interface [polypeptide binding]; other site 331271003356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271003357 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 331271003358 PLD-like domain; Region: PLDc_2; pfam13091 331271003359 putative active site [active] 331271003360 catalytic site [active] 331271003361 Predicted transcriptional regulators [Transcription]; Region: COG1733 331271003362 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 331271003363 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 331271003364 CoenzymeA binding site [chemical binding]; other site 331271003365 subunit interaction site [polypeptide binding]; other site 331271003366 PHB binding site; other site 331271003367 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271003368 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271003369 active site 331271003370 catalytic tetrad [active] 331271003371 citrate-proton symporter; Provisional; Region: PRK15075 331271003372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003373 putative substrate translocation pore; other site 331271003374 hypothetical protein; Provisional; Region: PRK07079 331271003375 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 331271003376 metal binding site [ion binding]; metal-binding site 331271003377 putative dimer interface [polypeptide binding]; other site 331271003378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271003379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271003380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271003381 dimerization interface [polypeptide binding]; other site 331271003382 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 331271003383 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 331271003384 active site residue [active] 331271003385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 331271003386 Predicted permease; Region: DUF318; cl17795 331271003387 ABC-2 type transporter; Region: ABC2_membrane; cl17235 331271003388 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 331271003389 nodulation ABC transporter NodI; Provisional; Region: PRK13537 331271003390 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 331271003391 Walker A/P-loop; other site 331271003392 ATP binding site [chemical binding]; other site 331271003393 Q-loop/lid; other site 331271003394 ABC transporter signature motif; other site 331271003395 Walker B; other site 331271003396 D-loop; other site 331271003397 H-loop/switch region; other site 331271003398 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271003399 Ligand Binding Site [chemical binding]; other site 331271003400 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 331271003401 LexA repressor; Validated; Region: PRK00215 331271003402 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 331271003403 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 331271003404 Catalytic site [active] 331271003405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271003406 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 331271003407 substrate binding pocket [chemical binding]; other site 331271003408 membrane-bound complex binding site; other site 331271003409 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 331271003410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003411 dimer interface [polypeptide binding]; other site 331271003412 conserved gate region; other site 331271003413 putative PBP binding loops; other site 331271003414 ABC-ATPase subunit interface; other site 331271003415 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 331271003416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003417 dimer interface [polypeptide binding]; other site 331271003418 conserved gate region; other site 331271003419 putative PBP binding loops; other site 331271003420 ABC-ATPase subunit interface; other site 331271003421 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 331271003422 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 331271003423 Walker A/P-loop; other site 331271003424 ATP binding site [chemical binding]; other site 331271003425 Q-loop/lid; other site 331271003426 ABC transporter signature motif; other site 331271003427 Walker B; other site 331271003428 D-loop; other site 331271003429 H-loop/switch region; other site 331271003430 TOBE-like domain; Region: TOBE_3; pfam12857 331271003431 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 331271003432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271003433 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 331271003434 substrate binding site [chemical binding]; other site 331271003435 dimerization interface [polypeptide binding]; other site 331271003436 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 331271003437 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271003438 ligand binding site [chemical binding]; other site 331271003439 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271003440 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271003441 Walker A/P-loop; other site 331271003442 ATP binding site [chemical binding]; other site 331271003443 Q-loop/lid; other site 331271003444 ABC transporter signature motif; other site 331271003445 Walker B; other site 331271003446 D-loop; other site 331271003447 H-loop/switch region; other site 331271003448 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271003449 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 331271003450 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271003451 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271003452 TM-ABC transporter signature motif; other site 331271003453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271003454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271003455 DNA binding site [nucleotide binding] 331271003456 domain linker motif; other site 331271003457 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 331271003458 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271003459 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 331271003460 substrate binding site [chemical binding]; other site 331271003461 dimer interface [polypeptide binding]; other site 331271003462 ATP binding site [chemical binding]; other site 331271003463 Tar ligand binding domain homologue; Region: TarH; pfam02203 331271003464 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271003465 dimerization interface [polypeptide binding]; other site 331271003466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271003467 dimer interface [polypeptide binding]; other site 331271003468 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 331271003469 putative CheW interface [polypeptide binding]; other site 331271003470 PrkA family serine protein kinase; Provisional; Region: PRK15455 331271003471 AAA ATPase domain; Region: AAA_16; pfam13191 331271003472 Walker A motif; other site 331271003473 ATP binding site [chemical binding]; other site 331271003474 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 331271003475 hypothetical protein; Provisional; Region: PRK05325 331271003476 SpoVR family protein; Provisional; Region: PRK11767 331271003477 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 331271003478 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 331271003479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003480 putative substrate translocation pore; other site 331271003481 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271003482 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271003483 substrate binding pocket [chemical binding]; other site 331271003484 membrane-bound complex binding site; other site 331271003485 hinge residues; other site 331271003486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003487 dimer interface [polypeptide binding]; other site 331271003488 conserved gate region; other site 331271003489 putative PBP binding loops; other site 331271003490 ABC-ATPase subunit interface; other site 331271003491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003492 dimer interface [polypeptide binding]; other site 331271003493 conserved gate region; other site 331271003494 putative PBP binding loops; other site 331271003495 ABC-ATPase subunit interface; other site 331271003496 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 331271003497 Peptidase family M23; Region: Peptidase_M23; pfam01551 331271003498 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 331271003499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271003500 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 331271003501 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 331271003502 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271003503 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271003504 multidrug efflux protein; Reviewed; Region: PRK09577 331271003505 Protein export membrane protein; Region: SecD_SecF; cl14618 331271003506 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271003507 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 331271003508 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 331271003509 PapC N-terminal domain; Region: PapC_N; pfam13954 331271003510 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 331271003511 PapC C-terminal domain; Region: PapC_C; pfam13953 331271003512 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 331271003513 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 331271003514 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 331271003515 Fimbrial protein; Region: Fimbrial; pfam00419 331271003516 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 331271003517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271003518 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 331271003519 MbtH-like protein; Region: MbtH; cl01279 331271003520 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 331271003521 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 331271003522 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 331271003523 Walker A/P-loop; other site 331271003524 ATP binding site [chemical binding]; other site 331271003525 Q-loop/lid; other site 331271003526 ABC transporter signature motif; other site 331271003527 Walker B; other site 331271003528 D-loop; other site 331271003529 H-loop/switch region; other site 331271003530 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 331271003531 FecCD transport family; Region: FecCD; pfam01032 331271003532 ABC-ATPase subunit interface; other site 331271003533 dimer interface [polypeptide binding]; other site 331271003534 putative PBP binding regions; other site 331271003535 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331271003536 ABC-ATPase subunit interface; other site 331271003537 dimer interface [polypeptide binding]; other site 331271003538 putative PBP binding regions; other site 331271003539 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 331271003540 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 331271003541 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 331271003542 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 331271003543 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 331271003544 siderophore binding site; other site 331271003545 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 331271003546 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 331271003547 Walker A/P-loop; other site 331271003548 ATP binding site [chemical binding]; other site 331271003549 Q-loop/lid; other site 331271003550 ABC transporter signature motif; other site 331271003551 Walker B; other site 331271003552 D-loop; other site 331271003553 H-loop/switch region; other site 331271003554 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 331271003555 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 331271003556 acyl-activating enzyme (AAE) consensus motif; other site 331271003557 AMP binding site [chemical binding]; other site 331271003558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271003559 Condensation domain; Region: Condensation; pfam00668 331271003560 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 331271003561 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 331271003562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271003563 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 331271003564 acyl-activating enzyme (AAE) consensus motif; other site 331271003565 AMP binding site [chemical binding]; other site 331271003566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271003567 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 331271003568 Condensation domain; Region: Condensation; pfam00668 331271003569 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 331271003570 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 331271003571 acyl-activating enzyme (AAE) consensus motif; other site 331271003572 AMP binding site [chemical binding]; other site 331271003573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271003574 Condensation domain; Region: Condensation; pfam00668 331271003575 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 331271003576 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 331271003577 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 331271003578 acyl-activating enzyme (AAE) consensus motif; other site 331271003579 AMP binding site [chemical binding]; other site 331271003580 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271003581 Condensation domain; Region: Condensation; pfam00668 331271003582 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 331271003583 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 331271003584 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271003585 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 331271003586 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 331271003587 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 331271003588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271003589 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 331271003590 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271003591 N-terminal plug; other site 331271003592 ligand-binding site [chemical binding]; other site 331271003593 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 331271003594 catalytic site [active] 331271003595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 331271003596 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 331271003597 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 331271003598 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 331271003599 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331271003600 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 331271003601 metal binding site [ion binding]; metal-binding site 331271003602 putative dimer interface [polypeptide binding]; other site 331271003603 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 331271003604 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 331271003605 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 331271003606 conserved cys residue [active] 331271003607 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 331271003608 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 331271003609 homodimer interface [polypeptide binding]; other site 331271003610 Walker A motif; other site 331271003611 ATP binding site [chemical binding]; other site 331271003612 hydroxycobalamin binding site [chemical binding]; other site 331271003613 Walker B motif; other site 331271003614 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 331271003615 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 331271003616 active site 331271003617 SAM binding site [chemical binding]; other site 331271003618 homodimer interface [polypeptide binding]; other site 331271003619 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271003620 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271003621 N-terminal plug; other site 331271003622 ligand-binding site [chemical binding]; other site 331271003623 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 331271003624 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 331271003625 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 331271003626 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 331271003627 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331271003628 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331271003629 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 331271003630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271003631 Walker A motif; other site 331271003632 ATP binding site [chemical binding]; other site 331271003633 Walker B motif; other site 331271003634 arginine finger; other site 331271003635 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 331271003636 metal ion-dependent adhesion site (MIDAS); other site 331271003637 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 331271003638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271003639 binding surface 331271003640 TPR motif; other site 331271003641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271003642 binding surface 331271003643 TPR motif; other site 331271003644 TPR repeat; Region: TPR_11; pfam13414 331271003645 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331271003646 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271003647 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 331271003648 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 331271003649 active site 331271003650 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 331271003651 nudix motif; other site 331271003652 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271003653 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271003654 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 331271003655 Citrate transporter; Region: CitMHS; pfam03600 331271003656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271003657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271003658 active site 331271003659 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271003660 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 331271003661 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271003662 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 331271003663 active site 331271003664 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 331271003665 aromatic chitin/cellulose binding site residues [chemical binding]; other site 331271003666 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 331271003667 aromatic chitin/cellulose binding site residues [chemical binding]; other site 331271003668 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 331271003669 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 331271003670 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 331271003671 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 331271003672 active site 331271003673 SAM binding site [chemical binding]; other site 331271003674 homodimer interface [polypeptide binding]; other site 331271003675 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 331271003676 active site 331271003677 SAM binding site [chemical binding]; other site 331271003678 homodimer interface [polypeptide binding]; other site 331271003679 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 331271003680 Precorrin-8X methylmutase; Region: CbiC; pfam02570 331271003681 precorrin-3B synthase; Region: CobG; TIGR02435 331271003682 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331271003683 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331271003684 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 331271003685 active site 331271003686 putative homodimer interface [polypeptide binding]; other site 331271003687 SAM binding site [chemical binding]; other site 331271003688 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 331271003689 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 331271003690 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 331271003691 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 331271003692 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 331271003693 active site 331271003694 SAM binding site [chemical binding]; other site 331271003695 homodimer interface [polypeptide binding]; other site 331271003696 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 331271003697 MarR family; Region: MarR_2; cl17246 331271003698 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271003699 Transposase, Mutator family; Region: Transposase_mut; pfam00872 331271003700 MULE transposase domain; Region: MULE; pfam10551 331271003701 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271003702 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 331271003703 C-terminal domain interface [polypeptide binding]; other site 331271003704 GSH binding site (G-site) [chemical binding]; other site 331271003705 dimer interface [polypeptide binding]; other site 331271003706 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 331271003707 dimer interface [polypeptide binding]; other site 331271003708 N-terminal domain interface [polypeptide binding]; other site 331271003709 Transposase, Mutator family; Region: Transposase_mut; pfam00872 331271003710 MULE transposase domain; Region: MULE; pfam10551 331271003711 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 331271003712 hypothetical protein; Provisional; Region: PRK11622 331271003713 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 331271003714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271003715 Walker A/P-loop; other site 331271003716 ATP binding site [chemical binding]; other site 331271003717 Q-loop/lid; other site 331271003718 ABC transporter signature motif; other site 331271003719 Walker B; other site 331271003720 D-loop; other site 331271003721 H-loop/switch region; other site 331271003722 TOBE domain; Region: TOBE_2; pfam08402 331271003723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003724 putative PBP binding loops; other site 331271003725 dimer interface [polypeptide binding]; other site 331271003726 ABC-ATPase subunit interface; other site 331271003727 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271003728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003729 dimer interface [polypeptide binding]; other site 331271003730 conserved gate region; other site 331271003731 putative PBP binding loops; other site 331271003732 ABC-ATPase subunit interface; other site 331271003733 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 331271003734 glycerate dehydrogenase; Provisional; Region: PRK06487 331271003735 putative ligand binding site [chemical binding]; other site 331271003736 putative NAD binding site [chemical binding]; other site 331271003737 catalytic site [active] 331271003738 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271003739 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271003740 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 331271003741 active site 331271003742 catalytic residues [active] 331271003743 metal binding site [ion binding]; metal-binding site 331271003744 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 331271003745 dimer interface [polypeptide binding]; other site 331271003746 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271003747 metal binding site [ion binding]; metal-binding site 331271003748 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 331271003749 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271003750 substrate binding pocket [chemical binding]; other site 331271003751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271003752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271003753 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 331271003754 putative dimerization interface [polypeptide binding]; other site 331271003755 benzoate transport; Region: 2A0115; TIGR00895 331271003756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003757 putative substrate translocation pore; other site 331271003758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003759 putative substrate translocation pore; other site 331271003760 Uncharacterized conserved protein [Function unknown]; Region: COG3791 331271003761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271003762 MarR family; Region: MarR; pfam01047 331271003763 Predicted acetyltransferase [General function prediction only]; Region: COG3393 331271003764 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271003765 Coenzyme A binding pocket [chemical binding]; other site 331271003766 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271003767 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271003768 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 331271003769 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 331271003770 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 331271003771 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 331271003772 Phage integrase protein; Region: DUF3701; pfam12482 331271003773 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 331271003774 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331271003775 active site 331271003776 DNA binding site [nucleotide binding] 331271003777 Int/Topo IB signature motif; other site 331271003778 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; cl04114 331271003779 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 331271003780 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271003781 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 331271003782 active site 331271003783 Serine hydrolase; Region: Ser_hydrolase; cl17834 331271003784 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 331271003785 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331271003786 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271003787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271003788 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271003789 DNA-binding site [nucleotide binding]; DNA binding site 331271003790 FCD domain; Region: FCD; pfam07729 331271003791 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 331271003792 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 331271003793 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 331271003794 active site 331271003795 Zn binding site [ion binding]; other site 331271003796 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271003797 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271003798 substrate binding pocket [chemical binding]; other site 331271003799 membrane-bound complex binding site; other site 331271003800 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 331271003801 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271003802 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271003803 trimer interface [polypeptide binding]; other site 331271003804 eyelet of channel; other site 331271003805 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 331271003806 Moco binding site; other site 331271003807 metal coordination site [ion binding]; other site 331271003808 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 331271003809 active site 331271003810 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 331271003811 dimer interface [polypeptide binding]; other site 331271003812 non-prolyl cis peptide bond; other site 331271003813 insertion regions; other site 331271003814 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 331271003815 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 331271003816 Flavin binding site [chemical binding]; other site 331271003817 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271003818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003819 dimer interface [polypeptide binding]; other site 331271003820 ABC-ATPase subunit interface; other site 331271003821 putative PBP binding loops; other site 331271003822 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271003823 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271003824 Walker A/P-loop; other site 331271003825 ATP binding site [chemical binding]; other site 331271003826 Q-loop/lid; other site 331271003827 ABC transporter signature motif; other site 331271003828 Walker B; other site 331271003829 D-loop; other site 331271003830 H-loop/switch region; other site 331271003831 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 331271003832 NMT1-like family; Region: NMT1_2; pfam13379 331271003833 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 331271003834 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 331271003835 oxidoreductase; Provisional; Region: PRK06128 331271003836 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 331271003837 NAD binding site [chemical binding]; other site 331271003838 metal binding site [ion binding]; metal-binding site 331271003839 active site 331271003840 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 331271003841 FOG: CBS domain [General function prediction only]; Region: COG0517 331271003842 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 331271003843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271003844 non-specific DNA binding site [nucleotide binding]; other site 331271003845 salt bridge; other site 331271003846 sequence-specific DNA binding site [nucleotide binding]; other site 331271003847 HipA N-terminal domain; Region: Couple_hipA; pfam13657 331271003848 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 331271003849 HipA-like N-terminal domain; Region: HipA_N; pfam07805 331271003850 HipA-like C-terminal domain; Region: HipA_C; pfam07804 331271003851 oxidoreductase; Provisional; Region: PRK06196 331271003852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271003853 NAD(P) binding site [chemical binding]; other site 331271003854 active site 331271003855 Cupin; Region: Cupin_6; pfam12852 331271003856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271003857 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271003858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271003859 OsmC-like protein; Region: OsmC; pfam02566 331271003860 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 331271003861 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271003862 putative ligand binding site [chemical binding]; other site 331271003863 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271003864 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271003865 TM-ABC transporter signature motif; other site 331271003866 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271003867 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271003868 Walker A/P-loop; other site 331271003869 ATP binding site [chemical binding]; other site 331271003870 Q-loop/lid; other site 331271003871 ABC transporter signature motif; other site 331271003872 Walker B; other site 331271003873 D-loop; other site 331271003874 H-loop/switch region; other site 331271003875 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271003876 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 331271003877 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 331271003878 active site 331271003879 non-prolyl cis peptide bond; other site 331271003880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003881 dimer interface [polypeptide binding]; other site 331271003882 conserved gate region; other site 331271003883 putative PBP binding loops; other site 331271003884 ABC-ATPase subunit interface; other site 331271003885 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271003886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 331271003887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003888 putative PBP binding loops; other site 331271003889 dimer interface [polypeptide binding]; other site 331271003890 ABC-ATPase subunit interface; other site 331271003891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271003892 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271003893 substrate binding pocket [chemical binding]; other site 331271003894 membrane-bound complex binding site; other site 331271003895 hinge residues; other site 331271003896 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 331271003897 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 331271003898 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 331271003899 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 331271003900 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271003901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271003902 Coenzyme A binding pocket [chemical binding]; other site 331271003903 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331271003904 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 331271003905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331271003906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 331271003907 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 331271003908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271003909 dimer interface [polypeptide binding]; other site 331271003910 conserved gate region; other site 331271003911 putative PBP binding loops; other site 331271003912 ABC-ATPase subunit interface; other site 331271003913 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 331271003914 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271003915 Walker A/P-loop; other site 331271003916 ATP binding site [chemical binding]; other site 331271003917 Q-loop/lid; other site 331271003918 ABC transporter signature motif; other site 331271003919 Walker B; other site 331271003920 D-loop; other site 331271003921 H-loop/switch region; other site 331271003922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271003923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271003924 Walker A/P-loop; other site 331271003925 ATP binding site [chemical binding]; other site 331271003926 Q-loop/lid; other site 331271003927 ABC transporter signature motif; other site 331271003928 Walker B; other site 331271003929 D-loop; other site 331271003930 H-loop/switch region; other site 331271003931 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271003932 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 331271003933 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 331271003934 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 331271003935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331271003936 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 331271003937 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 331271003938 PhnA protein; Region: PhnA; pfam03831 331271003939 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 331271003940 regulatory phosphorylation site [posttranslational modification]; other site 331271003941 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 331271003942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271003943 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 331271003944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271003945 active site 331271003946 phosphorylation site [posttranslational modification] 331271003947 intermolecular recognition site; other site 331271003948 dimerization interface [polypeptide binding]; other site 331271003949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271003950 DNA binding site [nucleotide binding] 331271003951 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271003952 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271003953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271003954 putative substrate translocation pore; other site 331271003955 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271003956 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 331271003957 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271003958 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 331271003959 nudix motif; other site 331271003960 BON domain; Region: BON; pfam04972 331271003961 Low affinity iron permease; Region: Iron_permease; pfam04120 331271003962 FRG domain; Region: FRG; pfam08867 331271003963 Domain of unknown function (DUF305); Region: DUF305; cl17794 331271003964 thiamine pyrophosphate protein; Provisional; Region: PRK08273 331271003965 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 331271003966 PYR/PP interface [polypeptide binding]; other site 331271003967 dimer interface [polypeptide binding]; other site 331271003968 tetramer interface [polypeptide binding]; other site 331271003969 TPP binding site [chemical binding]; other site 331271003970 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271003971 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 331271003972 TPP-binding site [chemical binding]; other site 331271003973 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 331271003974 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 331271003975 Cytochrome c; Region: Cytochrom_C; pfam00034 331271003976 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 331271003977 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 331271003978 D-pathway; other site 331271003979 Putative ubiquinol binding site [chemical binding]; other site 331271003980 Low-spin heme (heme b) binding site [chemical binding]; other site 331271003981 Putative water exit pathway; other site 331271003982 Binuclear center (heme o3/CuB) [ion binding]; other site 331271003983 K-pathway; other site 331271003984 Putative proton exit pathway; other site 331271003985 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 331271003986 Subunit I/III interface [polypeptide binding]; other site 331271003987 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271003988 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271003989 Cytochrome c; Region: Cytochrom_C; pfam00034 331271003990 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 331271003991 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271003992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271003993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271003994 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271003995 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271003996 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271003997 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331271003998 short chain dehydrogenase; Provisional; Region: PRK06179 331271003999 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271004000 NADP binding site [chemical binding]; other site 331271004001 active site 331271004002 steroid binding site; other site 331271004003 Tannase and feruloyl esterase; Region: Tannase; pfam07519 331271004004 Tannase and feruloyl esterase; Region: Tannase; pfam07519 331271004005 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 331271004006 homotrimer interaction site [polypeptide binding]; other site 331271004007 putative active site [active] 331271004008 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 331271004009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271004010 NAD(P) binding site [chemical binding]; other site 331271004011 active site 331271004012 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 331271004013 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271004014 catalytic loop [active] 331271004015 iron binding site [ion binding]; other site 331271004016 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 331271004017 FAD binding pocket [chemical binding]; other site 331271004018 FAD binding motif [chemical binding]; other site 331271004019 phosphate binding motif [ion binding]; other site 331271004020 beta-alpha-beta structure motif; other site 331271004021 NAD binding pocket [chemical binding]; other site 331271004022 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 331271004023 inter-subunit interface; other site 331271004024 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 331271004025 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 331271004026 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 331271004027 putative alpha subunit interface [polypeptide binding]; other site 331271004028 putative active site [active] 331271004029 putative substrate binding site [chemical binding]; other site 331271004030 Fe binding site [ion binding]; other site 331271004031 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 331271004032 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 331271004033 dimer interface [polypeptide binding]; other site 331271004034 active site 331271004035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271004036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271004037 DNA binding site [nucleotide binding] 331271004038 AAA ATPase domain; Region: AAA_16; pfam13191 331271004039 Predicted ATPase [General function prediction only]; Region: COG3903 331271004040 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 331271004041 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271004042 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271004043 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 331271004044 NAD(P) binding site [chemical binding]; other site 331271004045 catalytic residues [active] 331271004046 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 331271004047 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 331271004048 catalytic Zn binding site [ion binding]; other site 331271004049 NAD binding site [chemical binding]; other site 331271004050 structural Zn binding site [ion binding]; other site 331271004051 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271004052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271004053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004054 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271004055 putative effector binding pocket; other site 331271004056 dimerization interface [polypeptide binding]; other site 331271004057 short chain dehydrogenase; Provisional; Region: PRK06172 331271004058 classical (c) SDRs; Region: SDR_c; cd05233 331271004059 NAD(P) binding site [chemical binding]; other site 331271004060 active site 331271004061 putative arabinose transporter; Provisional; Region: PRK03545 331271004062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004063 putative substrate translocation pore; other site 331271004064 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331271004065 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 331271004066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271004067 motif II; other site 331271004068 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331271004069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271004070 S-adenosylmethionine binding site [chemical binding]; other site 331271004071 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 331271004072 substrate binding pocket [chemical binding]; other site 331271004073 substrate-Mg2+ binding site; other site 331271004074 aspartate-rich region 1; other site 331271004075 aspartate-rich region 2; other site 331271004076 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 331271004077 iron-sulfur cluster [ion binding]; other site 331271004078 [2Fe-2S] cluster binding site [ion binding]; other site 331271004079 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 331271004080 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 331271004081 [2Fe-2S] cluster binding site [ion binding]; other site 331271004082 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575 331271004083 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 331271004084 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 331271004085 MgtC family; Region: MgtC; pfam02308 331271004086 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 331271004087 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 331271004088 putative active site [active] 331271004089 catalytic site [active] 331271004090 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 331271004091 putative active site [active] 331271004092 catalytic site [active] 331271004093 Uncharacterized conserved protein [Function unknown]; Region: COG0398 331271004094 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 331271004095 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331271004096 putative catalytic site [active] 331271004097 putative metal binding site [ion binding]; other site 331271004098 putative phosphate binding site [ion binding]; other site 331271004099 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 331271004100 active site 331271004101 catalytic site [active] 331271004102 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 331271004103 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 331271004104 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 331271004105 active site 331271004106 homodimer interface [polypeptide binding]; other site 331271004107 catalytic site [active] 331271004108 acceptor binding site [chemical binding]; other site 331271004109 trehalose synthase; Region: treS_nterm; TIGR02456 331271004110 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 331271004111 active site 331271004112 catalytic site [active] 331271004113 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 331271004114 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 331271004115 glycogen branching enzyme; Provisional; Region: PRK05402 331271004116 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 331271004117 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 331271004118 active site 331271004119 catalytic site [active] 331271004120 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 331271004121 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 331271004122 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 331271004123 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 331271004124 active site 331271004125 catalytic site [active] 331271004126 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 331271004127 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 331271004128 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 331271004129 active site 331271004130 catalytic site [active] 331271004131 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 331271004132 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 331271004133 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 331271004134 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 331271004135 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 331271004136 active site 331271004137 catalytic site [active] 331271004138 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 331271004139 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 331271004140 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 331271004141 intracellular protease, PfpI family; Region: PfpI; TIGR01382 331271004142 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 331271004143 proposed catalytic triad [active] 331271004144 conserved cys residue [active] 331271004145 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 331271004146 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 331271004147 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 331271004148 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 331271004149 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 331271004150 active site 331271004151 DNA binding site [nucleotide binding] 331271004152 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 331271004153 DNA binding site [nucleotide binding] 331271004154 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 331271004155 nucleotide binding site [chemical binding]; other site 331271004156 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 331271004157 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 331271004158 putative DNA binding site [nucleotide binding]; other site 331271004159 putative homodimer interface [polypeptide binding]; other site 331271004160 hydroperoxidase II; Provisional; Region: katE; PRK11249 331271004161 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 331271004162 heme binding pocket [chemical binding]; other site 331271004163 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 331271004164 domain interactions; other site 331271004165 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 331271004166 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 331271004167 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 331271004168 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 331271004169 Domain of unknown function (DUF892); Region: DUF892; pfam05974 331271004170 FOG: CBS domain [General function prediction only]; Region: COG0517 331271004171 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 331271004172 PRC-barrel domain; Region: PRC; pfam05239 331271004173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271004174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004175 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 331271004176 putative effector binding pocket; other site 331271004177 putative dimerization interface [polypeptide binding]; other site 331271004178 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271004179 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271004180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004181 putative substrate translocation pore; other site 331271004182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271004183 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331271004184 active site 331271004185 phosphorylation site [posttranslational modification] 331271004186 intermolecular recognition site; other site 331271004187 dimerization interface [polypeptide binding]; other site 331271004188 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 331271004189 Fe-S cluster binding site [ion binding]; other site 331271004190 active site 331271004191 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 331271004192 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 331271004193 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 331271004194 short chain dehydrogenase; Provisional; Region: PRK06701 331271004195 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 331271004196 NAD binding site [chemical binding]; other site 331271004197 metal binding site [ion binding]; metal-binding site 331271004198 active site 331271004199 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 331271004200 short chain dehydrogenase; Provisional; Region: PRK07109 331271004201 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 331271004202 putative NAD(P) binding site [chemical binding]; other site 331271004203 active site 331271004204 BON domain; Region: BON; pfam04972 331271004205 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 331271004206 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 331271004207 putative ADP-binding pocket [chemical binding]; other site 331271004208 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271004209 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 331271004210 NAD binding site [chemical binding]; other site 331271004211 putative substrate binding site 2 [chemical binding]; other site 331271004212 putative substrate binding site 1 [chemical binding]; other site 331271004213 active site 331271004214 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271004215 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 331271004216 putative active site [active] 331271004217 heme pocket [chemical binding]; other site 331271004218 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 331271004219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271004220 putative active site [active] 331271004221 heme pocket [chemical binding]; other site 331271004222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271004223 dimer interface [polypeptide binding]; other site 331271004224 phosphorylation site [posttranslational modification] 331271004225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271004226 ATP binding site [chemical binding]; other site 331271004227 Mg2+ binding site [ion binding]; other site 331271004228 G-X-G motif; other site 331271004229 Response regulator receiver domain; Region: Response_reg; pfam00072 331271004230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271004231 active site 331271004232 phosphorylation site [posttranslational modification] 331271004233 intermolecular recognition site; other site 331271004234 dimerization interface [polypeptide binding]; other site 331271004235 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 331271004236 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 331271004237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331271004238 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331271004239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271004240 active site 331271004241 phosphorylation site [posttranslational modification] 331271004242 intermolecular recognition site; other site 331271004243 dimerization interface [polypeptide binding]; other site 331271004244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271004245 Walker A motif; other site 331271004246 ATP binding site [chemical binding]; other site 331271004247 Walker B motif; other site 331271004248 arginine finger; other site 331271004249 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271004250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271004251 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331271004252 Walker A motif; other site 331271004253 ATP binding site [chemical binding]; other site 331271004254 Walker B motif; other site 331271004255 arginine finger; other site 331271004256 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271004257 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271004258 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271004259 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331271004260 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331271004261 putative active site [active] 331271004262 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331271004263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331271004264 active site 331271004265 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 331271004266 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 331271004267 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331271004268 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331271004269 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331271004270 putative active site [active] 331271004271 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 331271004272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271004273 active site 331271004274 motif I; other site 331271004275 motif II; other site 331271004276 short chain dehydrogenase; Provisional; Region: PRK07326 331271004277 classical (c) SDRs; Region: SDR_c; cd05233 331271004278 NAD(P) binding site [chemical binding]; other site 331271004279 active site 331271004280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271004281 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 331271004282 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271004283 Walker A/P-loop; other site 331271004284 ATP binding site [chemical binding]; other site 331271004285 Q-loop/lid; other site 331271004286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271004287 ABC transporter signature motif; other site 331271004288 Walker B; other site 331271004289 D-loop; other site 331271004290 H-loop/switch region; other site 331271004291 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331271004292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271004293 active site 331271004294 phosphorylation site [posttranslational modification] 331271004295 intermolecular recognition site; other site 331271004296 dimerization interface [polypeptide binding]; other site 331271004297 BON domain; Region: BON; pfam04972 331271004298 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 331271004299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271004300 putative active site [active] 331271004301 heme pocket [chemical binding]; other site 331271004302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271004303 dimer interface [polypeptide binding]; other site 331271004304 phosphorylation site [posttranslational modification] 331271004305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271004306 ATP binding site [chemical binding]; other site 331271004307 Mg2+ binding site [ion binding]; other site 331271004308 G-X-G motif; other site 331271004309 Response regulator receiver domain; Region: Response_reg; pfam00072 331271004310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271004311 active site 331271004312 phosphorylation site [posttranslational modification] 331271004313 intermolecular recognition site; other site 331271004314 dimerization interface [polypeptide binding]; other site 331271004315 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 331271004316 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331271004317 NAD binding site [chemical binding]; other site 331271004318 catalytic Zn binding site [ion binding]; other site 331271004319 structural Zn binding site [ion binding]; other site 331271004320 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 331271004321 MarC family integral membrane protein; Region: MarC; cl00919 331271004322 AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The...; Region: Rieske_AIFL_N; cd03478 331271004323 [2Fe-2S] cluster binding site [ion binding]; other site 331271004324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 331271004325 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271004326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271004327 formate dehydrogenase; Provisional; Region: PRK07574 331271004328 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 331271004329 dimerization interface [polypeptide binding]; other site 331271004330 ligand binding site [chemical binding]; other site 331271004331 NAD binding site [chemical binding]; other site 331271004332 catalytic site [active] 331271004333 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271004334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271004335 DNA-binding site [nucleotide binding]; DNA binding site 331271004336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271004337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271004338 homodimer interface [polypeptide binding]; other site 331271004339 catalytic residue [active] 331271004340 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 331271004341 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 331271004342 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 331271004343 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 331271004344 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 331271004345 Clp amino terminal domain; Region: Clp_N; pfam02861 331271004346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271004347 Walker A motif; other site 331271004348 ATP binding site [chemical binding]; other site 331271004349 Walker B motif; other site 331271004350 arginine finger; other site 331271004351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271004352 Walker A motif; other site 331271004353 ATP binding site [chemical binding]; other site 331271004354 Walker B motif; other site 331271004355 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 331271004356 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 331271004357 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 331271004358 putative molybdopterin cofactor binding site [chemical binding]; other site 331271004359 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 331271004360 putative molybdopterin cofactor binding site; other site 331271004361 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331271004362 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331271004363 Sel1-like repeats; Region: SEL1; smart00671 331271004364 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271004365 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 331271004366 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271004367 putative active site [active] 331271004368 catalytic site [active] 331271004369 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271004370 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271004371 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 331271004372 putative active site [active] 331271004373 catalytic site [active] 331271004374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 331271004375 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 331271004376 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 331271004377 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 331271004378 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 331271004379 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 331271004380 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 331271004381 active site 331271004382 HIGH motif; other site 331271004383 dimer interface [polypeptide binding]; other site 331271004384 KMSKS motif; other site 331271004385 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 331271004386 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 331271004387 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 331271004388 active site 331271004389 ATP binding site [chemical binding]; other site 331271004390 substrate binding site [chemical binding]; other site 331271004391 activation loop (A-loop); other site 331271004392 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 331271004393 AAA domain; Region: AAA_11; pfam13086 331271004394 Part of AAA domain; Region: AAA_19; pfam13245 331271004395 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 331271004396 AAA domain; Region: AAA_12; pfam13087 331271004397 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 331271004398 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 331271004399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271004400 Zeta toxin; Region: Zeta_toxin; pfam06414 331271004401 Walker A motif; other site 331271004402 ATP binding site [chemical binding]; other site 331271004403 Walker B motif; other site 331271004404 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 331271004405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331271004406 active site 331271004407 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 331271004408 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 331271004409 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 331271004410 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 331271004411 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 331271004412 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 331271004413 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 331271004414 dimer interface [polypeptide binding]; other site 331271004415 putative functional site; other site 331271004416 putative MPT binding site; other site 331271004417 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 331271004418 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271004419 FeS/SAM binding site; other site 331271004420 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 331271004421 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 331271004422 MoaE homodimer interface [polypeptide binding]; other site 331271004423 MoaD interaction [polypeptide binding]; other site 331271004424 active site residues [active] 331271004425 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 331271004426 MoaE interaction surface [polypeptide binding]; other site 331271004427 MoeB interaction surface [polypeptide binding]; other site 331271004428 thiocarboxylated glycine; other site 331271004429 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 331271004430 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 331271004431 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 331271004432 acyl-activating enzyme (AAE) consensus motif; other site 331271004433 putative AMP binding site [chemical binding]; other site 331271004434 putative active site [active] 331271004435 putative CoA binding site [chemical binding]; other site 331271004436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271004437 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 331271004438 substrate binding site [chemical binding]; other site 331271004439 oxyanion hole (OAH) forming residues; other site 331271004440 trimer interface [polypeptide binding]; other site 331271004441 hypothetical protein; Provisional; Region: PRK06062 331271004442 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271004443 inhibitor-cofactor binding pocket; inhibition site 331271004444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271004445 catalytic residue [active] 331271004446 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271004447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004448 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271004449 dimerization interface [polypeptide binding]; other site 331271004450 substrate binding pocket [chemical binding]; other site 331271004451 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271004452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271004453 DNA-binding site [nucleotide binding]; DNA binding site 331271004454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271004455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271004456 homodimer interface [polypeptide binding]; other site 331271004457 catalytic residue [active] 331271004458 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271004459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271004460 DNA-binding site [nucleotide binding]; DNA binding site 331271004461 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271004462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271004463 homodimer interface [polypeptide binding]; other site 331271004464 catalytic residue [active] 331271004465 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271004466 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 331271004467 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271004468 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271004469 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271004470 dimerization interface [polypeptide binding]; other site 331271004471 ligand binding site [chemical binding]; other site 331271004472 TfoX N-terminal domain; Region: TfoX_N; pfam04993 331271004473 Phage integrase protein; Region: DUF3701; pfam12482 331271004474 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 331271004475 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 331271004476 Int/Topo IB signature motif; other site 331271004477 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 331271004478 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271004479 Ligand Binding Site [chemical binding]; other site 331271004480 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 331271004481 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271004482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004483 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 331271004484 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271004485 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271004486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271004488 dimerization interface [polypeptide binding]; other site 331271004489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271004490 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271004491 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271004492 short chain dehydrogenase; Provisional; Region: PRK06180 331271004493 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271004494 NADP binding site [chemical binding]; other site 331271004495 active site 331271004496 steroid binding site; other site 331271004497 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 331271004498 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271004499 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271004503 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 331271004504 homotrimer interaction site [polypeptide binding]; other site 331271004505 putative active site [active] 331271004506 Predicted transcriptional regulators [Transcription]; Region: COG1378 331271004507 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 331271004508 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 331271004509 C-terminal domain interface [polypeptide binding]; other site 331271004510 sugar binding site [chemical binding]; other site 331271004511 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 331271004512 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 331271004513 active site 331271004514 catalytic residues [active] 331271004515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004516 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271004517 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004518 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 331271004519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271004521 dimerization interface [polypeptide binding]; other site 331271004522 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271004523 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331271004524 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271004525 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271004526 ligand binding site [chemical binding]; other site 331271004527 flexible hinge region; other site 331271004528 Predicted membrane protein [Function unknown]; Region: COG2259 331271004529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271004530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271004531 DNA binding site [nucleotide binding] 331271004532 Predicted ATPase [General function prediction only]; Region: COG3903 331271004533 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271004534 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 331271004535 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271004536 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271004537 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271004538 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271004539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004540 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271004541 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 331271004542 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271004543 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271004544 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 331271004545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271004546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271004547 Cytochrome c; Region: Cytochrom_C; pfam00034 331271004548 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271004549 Cytochrome c; Region: Cytochrom_C; pfam00034 331271004550 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271004551 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271004552 catalytic loop [active] 331271004553 iron binding site [ion binding]; other site 331271004554 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271004555 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271004556 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271004557 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271004558 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271004559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271004560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004561 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271004562 putative effector binding pocket; other site 331271004563 putative dimerization interface [polypeptide binding]; other site 331271004564 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271004565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004566 putative substrate translocation pore; other site 331271004567 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271004568 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331271004569 FMN binding site [chemical binding]; other site 331271004570 active site 331271004571 substrate binding site [chemical binding]; other site 331271004572 catalytic residue [active] 331271004573 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 331271004574 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 331271004575 active site 331271004576 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271004577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271004578 DNA binding site [nucleotide binding] 331271004579 AAA ATPase domain; Region: AAA_16; pfam13191 331271004580 Predicted ATPase [General function prediction only]; Region: COG3903 331271004581 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271004582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 331271004585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271004586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004587 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271004588 putative effector binding pocket; other site 331271004589 dimerization interface [polypeptide binding]; other site 331271004590 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 331271004591 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331271004592 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 331271004593 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 331271004594 active site 331271004595 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 331271004596 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 331271004597 Isochorismatase family; Region: Isochorismatase; pfam00857 331271004598 catalytic triad [active] 331271004599 dimer interface [polypeptide binding]; other site 331271004600 conserved cis-peptide bond; other site 331271004601 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 331271004602 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 331271004603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271004605 dimerization interface [polypeptide binding]; other site 331271004606 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 331271004607 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 331271004608 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271004609 hypothetical protein; Provisional; Region: PRK07236 331271004610 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 331271004611 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271004612 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 331271004613 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271004614 Walker A/P-loop; other site 331271004615 ATP binding site [chemical binding]; other site 331271004616 Q-loop/lid; other site 331271004617 ABC transporter signature motif; other site 331271004618 Walker B; other site 331271004619 D-loop; other site 331271004620 H-loop/switch region; other site 331271004621 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271004622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271004623 dimer interface [polypeptide binding]; other site 331271004624 conserved gate region; other site 331271004625 putative PBP binding loops; other site 331271004626 ABC-ATPase subunit interface; other site 331271004627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271004628 dimer interface [polypeptide binding]; other site 331271004629 conserved gate region; other site 331271004630 putative PBP binding loops; other site 331271004631 ABC-ATPase subunit interface; other site 331271004632 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271004633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271004634 substrate binding pocket [chemical binding]; other site 331271004635 membrane-bound complex binding site; other site 331271004636 hinge residues; other site 331271004637 L-asparagine permease; Provisional; Region: PRK15049 331271004638 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271004639 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331271004640 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271004641 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271004642 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271004643 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271004644 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 331271004645 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 331271004646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271004647 dimer interface [polypeptide binding]; other site 331271004648 phosphorylation site [posttranslational modification] 331271004649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271004650 ATP binding site [chemical binding]; other site 331271004651 Mg2+ binding site [ion binding]; other site 331271004652 G-X-G motif; other site 331271004653 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 331271004654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271004655 active site 331271004656 phosphorylation site [posttranslational modification] 331271004657 intermolecular recognition site; other site 331271004658 dimerization interface [polypeptide binding]; other site 331271004659 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271004660 DNA binding site [nucleotide binding] 331271004661 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271004662 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 331271004663 conserved cys residue [active] 331271004664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004665 choline dehydrogenase; Validated; Region: PRK02106 331271004666 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271004667 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 331271004668 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271004669 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 331271004670 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271004671 YCII-related domain; Region: YCII; cl00999 331271004672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004673 putative substrate translocation pore; other site 331271004674 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 331271004675 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 331271004676 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 331271004677 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 331271004678 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 331271004679 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271004680 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271004681 trimer interface [polypeptide binding]; other site 331271004682 eyelet of channel; other site 331271004683 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 331271004684 histidinol dehydrogenase; Region: hisD; TIGR00069 331271004685 NAD binding site [chemical binding]; other site 331271004686 dimerization interface [polypeptide binding]; other site 331271004687 product binding site; other site 331271004688 substrate binding site [chemical binding]; other site 331271004689 zinc binding site [ion binding]; other site 331271004690 catalytic residues [active] 331271004691 Trehalose utilisation; Region: ThuA; pfam06283 331271004692 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 331271004693 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271004694 PYR/PP interface [polypeptide binding]; other site 331271004695 dimer interface [polypeptide binding]; other site 331271004696 TPP binding site [chemical binding]; other site 331271004697 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271004698 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 331271004699 TPP-binding site [chemical binding]; other site 331271004700 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 331271004701 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271004702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271004703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271004704 DNA binding site [nucleotide binding] 331271004705 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 331271004706 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 331271004707 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 331271004708 active site 331271004709 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271004710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271004711 dimer interface [polypeptide binding]; other site 331271004712 conserved gate region; other site 331271004713 putative PBP binding loops; other site 331271004714 ABC-ATPase subunit interface; other site 331271004715 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271004716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271004717 dimer interface [polypeptide binding]; other site 331271004718 putative PBP binding loops; other site 331271004719 ABC-ATPase subunit interface; other site 331271004720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271004721 sequence-specific DNA binding site [nucleotide binding]; other site 331271004722 salt bridge; other site 331271004723 Transposase domain (DUF772); Region: DUF772; pfam05598 331271004724 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331271004725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271004727 putative substrate translocation pore; other site 331271004728 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 331271004729 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 331271004730 classical (c) SDRs; Region: SDR_c; cd05233 331271004731 NAD(P) binding site [chemical binding]; other site 331271004732 active site 331271004733 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 331271004734 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 331271004735 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 331271004736 BNR repeat-like domain; Region: BNR_2; pfam13088 331271004737 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 331271004738 Na binding site [ion binding]; other site 331271004739 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 331271004740 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 331271004741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 331271004742 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 331271004743 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 331271004744 putative active site [active] 331271004745 metal binding site [ion binding]; metal-binding site 331271004746 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271004747 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271004748 inhibitor site; inhibition site 331271004749 active site 331271004750 dimer interface [polypeptide binding]; other site 331271004751 catalytic residue [active] 331271004752 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271004753 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 331271004754 substrate binding site [chemical binding]; other site 331271004755 dimer interface [polypeptide binding]; other site 331271004756 ATP binding site [chemical binding]; other site 331271004757 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 331271004758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004760 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 331271004761 active site 331271004762 catalytic residues [active] 331271004763 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 331271004764 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 331271004765 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 331271004766 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 331271004767 intersubunit interface [polypeptide binding]; other site 331271004768 active site 331271004769 catalytic residue [active] 331271004770 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 331271004771 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 331271004772 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 331271004773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271004774 Walker A motif; other site 331271004775 ATP binding site [chemical binding]; other site 331271004776 Walker B motif; other site 331271004777 EamA-like transporter family; Region: EamA; pfam00892 331271004778 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 331271004779 EamA-like transporter family; Region: EamA; pfam00892 331271004780 Cupin domain; Region: Cupin_2; cl17218 331271004781 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271004782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004784 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 331271004785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271004786 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331271004787 NAD(P) binding site [chemical binding]; other site 331271004788 active site 331271004789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271004790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271004791 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 331271004792 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271004793 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271004794 beta-ketothiolase; Provisional; Region: PRK09051 331271004795 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271004796 dimer interface [polypeptide binding]; other site 331271004797 active site 331271004798 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 331271004799 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271004800 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 331271004801 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 331271004802 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 331271004803 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 331271004804 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271004805 active site 331271004806 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 331271004807 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271004808 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271004809 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004810 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 331271004811 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 331271004812 acyl-activating enzyme (AAE) consensus motif; other site 331271004813 putative AMP binding site [chemical binding]; other site 331271004814 putative active site [active] 331271004815 putative CoA binding site [chemical binding]; other site 331271004816 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 331271004817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 331271004818 active site 331271004819 motif I; other site 331271004820 motif II; other site 331271004821 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271004822 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271004823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271004825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271004826 dimer interface [polypeptide binding]; other site 331271004827 phosphorylation site [posttranslational modification] 331271004828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271004829 ATP binding site [chemical binding]; other site 331271004830 Mg2+ binding site [ion binding]; other site 331271004831 G-X-G motif; other site 331271004832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271004833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271004834 active site 331271004835 phosphorylation site [posttranslational modification] 331271004836 intermolecular recognition site; other site 331271004837 dimerization interface [polypeptide binding]; other site 331271004838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271004839 DNA binding site [nucleotide binding] 331271004840 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271004841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271004842 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 331271004843 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 331271004844 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271004845 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271004846 metal binding site [ion binding]; metal-binding site 331271004847 active site 331271004848 I-site; other site 331271004849 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271004850 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271004851 trimer interface [polypeptide binding]; other site 331271004852 eyelet of channel; other site 331271004853 benzoate transport; Region: 2A0115; TIGR00895 331271004854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004855 putative substrate translocation pore; other site 331271004856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271004857 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271004858 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271004859 inhibitor site; inhibition site 331271004860 active site 331271004861 dimer interface [polypeptide binding]; other site 331271004862 catalytic residue [active] 331271004863 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271004864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004865 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271004866 dimerization interface [polypeptide binding]; other site 331271004867 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 331271004868 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331271004869 Sel1-like repeats; Region: SEL1; smart00671 331271004870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271004871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271004872 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 331271004873 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 331271004874 CheB methylesterase; Region: CheB_methylest; pfam01339 331271004875 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 331271004876 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 331271004877 dimanganese center [ion binding]; other site 331271004878 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 331271004879 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 331271004880 ring oligomerisation interface [polypeptide binding]; other site 331271004881 ATP/Mg binding site [chemical binding]; other site 331271004882 stacking interactions; other site 331271004883 hinge regions; other site 331271004884 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 331271004885 oligomerisation interface [polypeptide binding]; other site 331271004886 mobile loop; other site 331271004887 roof hairpin; other site 331271004888 Domain of unknown function (DUF336); Region: DUF336; cl01249 331271004889 short chain dehydrogenase; Provisional; Region: PRK09291 331271004890 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271004891 NADP binding site [chemical binding]; other site 331271004892 active site 331271004893 steroid binding site; other site 331271004894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271004895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271004896 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 331271004897 putative effector binding pocket; other site 331271004898 putative dimerization interface [polypeptide binding]; other site 331271004899 methionine sulfoxide reductase B; Provisional; Region: PRK00222 331271004900 SelR domain; Region: SelR; pfam01641 331271004901 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 331271004902 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 331271004903 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 331271004904 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271004905 catalytic residues [active] 331271004906 methionine sulfoxide reductase A; Provisional; Region: PRK13014 331271004907 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 331271004908 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 331271004909 [2Fe-2S] cluster binding site [ion binding]; other site 331271004910 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 331271004911 active site 331271004912 catalytic motif [active] 331271004913 Zn binding site [ion binding]; other site 331271004914 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 331271004915 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 331271004916 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 331271004917 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 331271004918 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 331271004919 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 331271004920 Nucleoside recognition; Region: Gate; pfam07670 331271004921 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 331271004922 phenylhydantoinase; Validated; Region: PRK08323 331271004923 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 331271004924 tetramer interface [polypeptide binding]; other site 331271004925 active site 331271004926 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 331271004927 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 331271004928 Na binding site [ion binding]; other site 331271004929 putative substrate binding site [chemical binding]; other site 331271004930 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 331271004931 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 331271004932 homodimer interface [polypeptide binding]; other site 331271004933 active site 331271004934 FMN binding site [chemical binding]; other site 331271004935 substrate binding site [chemical binding]; other site 331271004936 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331271004937 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 331271004938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271004939 allantoate amidohydrolase; Reviewed; Region: PRK09290 331271004940 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 331271004941 active site 331271004942 metal binding site [ion binding]; metal-binding site 331271004943 dimer interface [polypeptide binding]; other site 331271004944 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 331271004945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271004946 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 331271004947 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 331271004948 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271004949 dimer interface [polypeptide binding]; other site 331271004950 active site 331271004951 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 331271004952 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 331271004953 NAD binding site [chemical binding]; other site 331271004954 homodimer interface [polypeptide binding]; other site 331271004955 homotetramer interface [polypeptide binding]; other site 331271004956 active site 331271004957 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 331271004958 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_2; cd05973 331271004959 active site 331271004960 acyl-activating enzyme (AAE) consensus motif; other site 331271004961 putative CoA binding site [chemical binding]; other site 331271004962 AMP binding site [chemical binding]; other site 331271004963 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271004964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271004965 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271004966 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271004967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271004968 Coenzyme A binding pocket [chemical binding]; other site 331271004969 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 331271004970 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271004971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 331271004972 active site 331271004973 phosphorylation site [posttranslational modification] 331271004974 dimerization interface [polypeptide binding]; other site 331271004975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271004976 DNA binding residues [nucleotide binding] 331271004977 Predicted membrane protein [Function unknown]; Region: COG3235 331271004978 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 331271004979 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 331271004980 putative active site [active] 331271004981 Zn binding site [ion binding]; other site 331271004982 hypothetical protein; Validated; Region: PRK02101 331271004983 PIN domain; Region: PIN_3; pfam13470 331271004984 methionine aminotransferase; Validated; Region: PRK09082 331271004985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271004986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271004987 homodimer interface [polypeptide binding]; other site 331271004988 catalytic residue [active] 331271004989 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271004990 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 331271004991 C-terminal domain interface [polypeptide binding]; other site 331271004992 GSH binding site (G-site) [chemical binding]; other site 331271004993 dimer interface [polypeptide binding]; other site 331271004994 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 331271004995 putative N-terminal domain interface [polypeptide binding]; other site 331271004996 putative dimer interface [polypeptide binding]; other site 331271004997 putative substrate binding pocket (H-site) [chemical binding]; other site 331271004998 enoyl-CoA hydratase; Provisional; Region: PRK07511 331271004999 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271005000 substrate binding site [chemical binding]; other site 331271005001 oxyanion hole (OAH) forming residues; other site 331271005002 trimer interface [polypeptide binding]; other site 331271005003 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 331271005004 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 331271005005 C-terminal domain interface [polypeptide binding]; other site 331271005006 GSH binding site (G-site) [chemical binding]; other site 331271005007 dimer interface [polypeptide binding]; other site 331271005008 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 331271005009 N-terminal domain interface [polypeptide binding]; other site 331271005010 putative dimer interface [polypeptide binding]; other site 331271005011 active site 331271005012 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 331271005013 putative active site [active] 331271005014 putative catalytic site [active] 331271005015 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 331271005016 putative active site [active] 331271005017 putative catalytic site [active] 331271005018 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 331271005019 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 331271005020 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 331271005021 active site 331271005022 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 331271005023 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 331271005024 FAD binding site [chemical binding]; other site 331271005025 substrate binding site [chemical binding]; other site 331271005026 catalytic base [active] 331271005027 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 331271005028 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 331271005029 dimer interface [polypeptide binding]; other site 331271005030 ADP-ribose binding site [chemical binding]; other site 331271005031 active site 331271005032 nudix motif; other site 331271005033 metal binding site [ion binding]; metal-binding site 331271005034 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 331271005035 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 331271005036 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331271005037 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 331271005038 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331271005039 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 331271005040 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 331271005041 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331271005042 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 331271005043 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 331271005044 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 331271005045 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 331271005046 4Fe-4S binding domain; Region: Fer4; cl02805 331271005047 4Fe-4S binding domain; Region: Fer4; pfam00037 331271005048 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 331271005049 NADH dehydrogenase subunit G; Validated; Region: PRK09129 331271005050 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271005051 catalytic loop [active] 331271005052 iron binding site [ion binding]; other site 331271005053 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 331271005054 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 331271005055 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 331271005056 SLBB domain; Region: SLBB; pfam10531 331271005057 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 331271005058 NADH dehydrogenase subunit E; Validated; Region: PRK07539 331271005059 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 331271005060 putative dimer interface [polypeptide binding]; other site 331271005061 [2Fe-2S] cluster binding site [ion binding]; other site 331271005062 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 331271005063 NADH dehydrogenase subunit D; Validated; Region: PRK06075 331271005064 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 331271005065 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 331271005066 NADH dehydrogenase subunit B; Validated; Region: PRK06411 331271005067 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 331271005068 Preprotein translocase SecG subunit; Region: SecG; pfam03840 331271005069 triosephosphate isomerase; Provisional; Region: PRK14567 331271005070 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 331271005071 substrate binding site [chemical binding]; other site 331271005072 dimer interface [polypeptide binding]; other site 331271005073 catalytic triad [active] 331271005074 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 331271005075 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 331271005076 NAD(P) binding site [chemical binding]; other site 331271005077 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 331271005078 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 331271005079 RNase E interface [polypeptide binding]; other site 331271005080 trimer interface [polypeptide binding]; other site 331271005081 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 331271005082 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 331271005083 RNase E interface [polypeptide binding]; other site 331271005084 trimer interface [polypeptide binding]; other site 331271005085 active site 331271005086 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 331271005087 putative nucleic acid binding region [nucleotide binding]; other site 331271005088 G-X-X-G motif; other site 331271005089 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 331271005090 RNA binding site [nucleotide binding]; other site 331271005091 domain interface; other site 331271005092 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 331271005093 16S/18S rRNA binding site [nucleotide binding]; other site 331271005094 S13e-L30e interaction site [polypeptide binding]; other site 331271005095 25S rRNA binding site [nucleotide binding]; other site 331271005096 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 331271005097 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 331271005098 putative ligand binding site [chemical binding]; other site 331271005099 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 331271005100 active site clefts [active] 331271005101 zinc binding site [ion binding]; other site 331271005102 dimer interface [polypeptide binding]; other site 331271005103 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 331271005104 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 331271005105 Sulfate transporter family; Region: Sulfate_transp; pfam00916 331271005106 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 331271005107 2-isopropylmalate synthase; Validated; Region: PRK00915 331271005108 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 331271005109 active site 331271005110 catalytic residues [active] 331271005111 metal binding site [ion binding]; metal-binding site 331271005112 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 331271005113 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 331271005114 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 331271005115 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 331271005116 ketol-acid reductoisomerase; Provisional; Region: PRK05479 331271005117 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 331271005118 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 331271005119 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 331271005120 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 331271005121 putative valine binding site [chemical binding]; other site 331271005122 dimer interface [polypeptide binding]; other site 331271005123 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 331271005124 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 331271005125 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271005126 PYR/PP interface [polypeptide binding]; other site 331271005127 dimer interface [polypeptide binding]; other site 331271005128 TPP binding site [chemical binding]; other site 331271005129 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271005130 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 331271005131 TPP-binding site [chemical binding]; other site 331271005132 dimer interface [polypeptide binding]; other site 331271005133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271005134 RNA polymerase factor sigma-70; Validated; Region: PRK09047 331271005135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271005136 DNA binding residues [nucleotide binding] 331271005137 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 331271005138 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 331271005139 RDD family; Region: RDD; pfam06271 331271005140 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 331271005141 putative active site [active] 331271005142 putative metal binding site [ion binding]; other site 331271005143 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271005144 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 331271005145 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 331271005146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271005147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271005148 Bacterial transcriptional repressor; Region: TetR; pfam13972 331271005149 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331271005150 glucose-1-dehydrogenase; Provisional; Region: PRK06947 331271005151 classical (c) SDRs; Region: SDR_c; cd05233 331271005152 NAD(P) binding site [chemical binding]; other site 331271005153 active site 331271005154 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 331271005155 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 331271005156 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 331271005157 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 331271005158 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 331271005159 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 331271005160 apolar tunnel; other site 331271005161 heme binding site [chemical binding]; other site 331271005162 dimerization interface [polypeptide binding]; other site 331271005163 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 331271005164 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 331271005165 multidrug efflux system protein; Provisional; Region: PRK11431 331271005166 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 331271005167 Domain of unknown function (DUF333); Region: DUF333; pfam03891 331271005168 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 331271005169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271005170 active site 331271005171 phosphorylation site [posttranslational modification] 331271005172 intermolecular recognition site; other site 331271005173 dimerization interface [polypeptide binding]; other site 331271005174 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271005175 DNA binding site [nucleotide binding] 331271005176 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 331271005177 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 331271005178 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 331271005179 Ligand Binding Site [chemical binding]; other site 331271005180 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 331271005181 GAF domain; Region: GAF_3; pfam13492 331271005182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271005183 dimer interface [polypeptide binding]; other site 331271005184 phosphorylation site [posttranslational modification] 331271005185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271005186 ATP binding site [chemical binding]; other site 331271005187 Mg2+ binding site [ion binding]; other site 331271005188 G-X-G motif; other site 331271005189 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 331271005190 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 331271005191 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331271005192 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 331271005193 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 331271005194 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 331271005195 NADP binding site [chemical binding]; other site 331271005196 dimer interface [polypeptide binding]; other site 331271005197 methylglyoxal synthase; Validated; Region: mgsA; PRK05234 331271005198 substrate binding site [chemical binding]; other site 331271005199 short chain dehydrogenase; Provisional; Region: PRK08339 331271005200 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 331271005201 putative NAD(P) binding site [chemical binding]; other site 331271005202 putative active site [active] 331271005203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271005204 active site 331271005205 hypothetical protein; Validated; Region: PRK00110 331271005206 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 331271005207 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 331271005208 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 331271005209 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 331271005210 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 331271005211 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 331271005212 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 331271005213 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 331271005214 active site 331271005215 (T/H)XGH motif; other site 331271005216 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 331271005217 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 331271005218 Maf-like protein; Region: Maf; pfam02545 331271005219 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 331271005220 active site 331271005221 dimer interface [polypeptide binding]; other site 331271005222 ribonuclease G; Provisional; Region: PRK11712 331271005223 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 331271005224 homodimer interface [polypeptide binding]; other site 331271005225 oligonucleotide binding site [chemical binding]; other site 331271005226 Protein with unknown function (DUF469); Region: DUF469; pfam04320 331271005227 PRC-barrel domain; Region: PRC; pfam05239 331271005228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271005229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271005230 putative substrate translocation pore; other site 331271005231 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 331271005232 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 331271005233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271005234 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 331271005235 Walker A/P-loop; other site 331271005236 ATP binding site [chemical binding]; other site 331271005237 Q-loop/lid; other site 331271005238 ABC transporter signature motif; other site 331271005239 Walker B; other site 331271005240 D-loop; other site 331271005241 H-loop/switch region; other site 331271005242 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 331271005243 putative metal binding site; other site 331271005244 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 331271005245 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 331271005246 active site 331271005247 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 331271005248 O-Antigen ligase; Region: Wzy_C; pfam04932 331271005249 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331271005250 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331271005251 putative active site [active] 331271005252 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331271005253 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271005254 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271005255 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 331271005256 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 331271005257 putative active site [active] 331271005258 putative PHP Thumb interface [polypeptide binding]; other site 331271005259 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 331271005260 generic binding surface II; other site 331271005261 generic binding surface I; other site 331271005262 rhodanese superfamily protein; Provisional; Region: PRK05320 331271005263 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 331271005264 active site residue [active] 331271005265 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 331271005266 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 331271005267 active site 331271005268 HIGH motif; other site 331271005269 nucleotide binding site [chemical binding]; other site 331271005270 active site 331271005271 KMSKS motif; other site 331271005272 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331271005273 DEAD-like helicases superfamily; Region: DEXDc; smart00487 331271005274 ATP binding site [chemical binding]; other site 331271005275 Mg++ binding site [ion binding]; other site 331271005276 motif III; other site 331271005277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271005278 nucleotide binding region [chemical binding]; other site 331271005279 ATP-binding site [chemical binding]; other site 331271005280 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 331271005281 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 331271005282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271005283 ATP-grasp domain; Region: ATP-grasp; pfam02222 331271005284 META domain; Region: META; pfam03724 331271005285 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 331271005286 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 331271005287 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 331271005288 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 331271005289 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 331271005290 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 331271005291 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 331271005292 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 331271005293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271005294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271005295 ferredoxin; Provisional; Region: PRK08764 331271005296 Putative Fe-S cluster; Region: FeS; pfam04060 331271005297 4Fe-4S binding domain; Region: Fer4; pfam00037 331271005298 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 331271005299 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331271005300 minor groove reading motif; other site 331271005301 helix-hairpin-helix signature motif; other site 331271005302 substrate binding pocket [chemical binding]; other site 331271005303 active site 331271005304 EamA-like transporter family; Region: EamA; pfam00892 331271005305 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 331271005306 EamA-like transporter family; Region: EamA; pfam00892 331271005307 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 331271005308 Cytochrome c553 [Energy production and conversion]; Region: COG2863 331271005309 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271005310 Cytochrome c553 [Energy production and conversion]; Region: COG2863 331271005311 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331271005312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271005313 Walker A motif; other site 331271005314 ATP binding site [chemical binding]; other site 331271005315 Walker B motif; other site 331271005316 arginine finger; other site 331271005317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 331271005318 Benzoate membrane transport protein; Region: BenE; pfam03594 331271005319 benzoate transporter; Region: benE; TIGR00843 331271005320 transaldolase-like protein; Provisional; Region: PTZ00411 331271005321 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 331271005322 active site 331271005323 dimer interface [polypeptide binding]; other site 331271005324 catalytic residue [active] 331271005325 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 331271005326 dimer interface [polypeptide binding]; other site 331271005327 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271005328 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 331271005329 Na binding site [ion binding]; other site 331271005330 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 331271005331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331271005332 conjugal transfer protein TraL; Provisional; Region: PRK13886 331271005333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271005334 putative Zn2+ binding site [ion binding]; other site 331271005335 putative DNA binding site [nucleotide binding]; other site 331271005336 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331271005337 active site 331271005338 NTP binding site [chemical binding]; other site 331271005339 metal binding triad [ion binding]; metal-binding site 331271005340 antibiotic binding site [chemical binding]; other site 331271005341 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 331271005342 putative active site [active] 331271005343 Chorismate lyase; Region: Chor_lyase; cl01230 331271005344 heat shock protein 90; Provisional; Region: PRK05218 331271005345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271005346 ATP binding site [chemical binding]; other site 331271005347 Mg2+ binding site [ion binding]; other site 331271005348 G-X-G motif; other site 331271005349 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271005350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271005351 DNA-binding site [nucleotide binding]; DNA binding site 331271005352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271005353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271005354 homodimer interface [polypeptide binding]; other site 331271005355 catalytic residue [active] 331271005356 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 331271005357 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331271005358 EamA-like transporter family; Region: EamA; pfam00892 331271005359 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 331271005360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271005361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271005362 homodimer interface [polypeptide binding]; other site 331271005363 catalytic residue [active] 331271005364 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 331271005365 homotrimer interaction site [polypeptide binding]; other site 331271005366 putative active site [active] 331271005367 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 331271005368 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 331271005369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271005370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271005371 metal binding site [ion binding]; metal-binding site 331271005372 active site 331271005373 I-site; other site 331271005374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271005375 Chromate transporter; Region: Chromate_transp; pfam02417 331271005376 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 331271005377 Chromate transporter; Region: Chromate_transp; pfam02417 331271005378 Predicted membrane protein [Function unknown]; Region: COG4125 331271005379 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 331271005380 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 331271005381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271005382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271005383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271005384 dimerization interface [polypeptide binding]; other site 331271005385 Copper resistance protein D; Region: CopD; cl00563 331271005386 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 331271005387 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 331271005388 CAP-like domain; other site 331271005389 active site 331271005390 primary dimer interface [polypeptide binding]; other site 331271005391 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331271005392 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 331271005393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271005394 ATP binding site [chemical binding]; other site 331271005395 Mg2+ binding site [ion binding]; other site 331271005396 G-X-G motif; other site 331271005397 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 331271005398 anchoring element; other site 331271005399 dimer interface [polypeptide binding]; other site 331271005400 ATP binding site [chemical binding]; other site 331271005401 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 331271005402 active site 331271005403 metal binding site [ion binding]; metal-binding site 331271005404 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 331271005405 ABC transporter ATPase component; Reviewed; Region: PRK11147 331271005406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271005407 Walker A/P-loop; other site 331271005408 ATP binding site [chemical binding]; other site 331271005409 Q-loop/lid; other site 331271005410 ABC transporter signature motif; other site 331271005411 Walker B; other site 331271005412 D-loop; other site 331271005413 H-loop/switch region; other site 331271005414 ABC transporter; Region: ABC_tran_2; pfam12848 331271005415 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271005416 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 331271005417 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331271005418 Rubredoxin; Region: Rubredoxin; pfam00301 331271005419 iron binding site [ion binding]; other site 331271005420 integrase; Provisional; Region: PRK09692 331271005421 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 331271005422 active site 331271005423 Int/Topo IB signature motif; other site 331271005424 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 331271005425 Domain of unknown function (DUF927); Region: DUF927; pfam06048 331271005426 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 331271005427 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 331271005428 ATP binding site [chemical binding]; other site 331271005429 Mg2+ binding site [ion binding]; other site 331271005430 G-X-G motif; other site 331271005431 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 331271005432 anti sigma factor interaction site; other site 331271005433 regulatory phosphorylation site [posttranslational modification]; other site 331271005434 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 331271005435 multiple promoter invertase; Provisional; Region: mpi; PRK13413 331271005436 catalytic residues [active] 331271005437 catalytic nucleophile [active] 331271005438 Presynaptic Site I dimer interface [polypeptide binding]; other site 331271005439 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 331271005440 Synaptic Flat tetramer interface [polypeptide binding]; other site 331271005441 Synaptic Site I dimer interface [polypeptide binding]; other site 331271005442 DNA binding site [nucleotide binding] 331271005443 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 331271005444 DNA-binding interface [nucleotide binding]; DNA binding site 331271005445 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 331271005446 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 331271005447 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 331271005448 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 331271005449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271005450 S-adenosylmethionine binding site [chemical binding]; other site 331271005451 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 331271005452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 331271005453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271005454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271005455 DNA binding residues [nucleotide binding] 331271005456 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 331271005457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271005458 NAD(P) binding site [chemical binding]; other site 331271005459 active site 331271005460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271005461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271005462 ecotin; Provisional; Region: PRK03719 331271005463 secondary substrate binding site; other site 331271005464 primary substrate binding site; other site 331271005465 inhibition loop; other site 331271005466 dimerization interface [polypeptide binding]; other site 331271005467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271005468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271005469 putative substrate translocation pore; other site 331271005470 Predicted ATPase [General function prediction only]; Region: COG3911 331271005471 AAA domain; Region: AAA_28; pfam13521 331271005472 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 331271005473 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 331271005474 active site 331271005475 homotetramer interface [polypeptide binding]; other site 331271005476 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271005477 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271005478 Walker A/P-loop; other site 331271005479 ATP binding site [chemical binding]; other site 331271005480 Q-loop/lid; other site 331271005481 ABC transporter signature motif; other site 331271005482 Walker B; other site 331271005483 D-loop; other site 331271005484 H-loop/switch region; other site 331271005485 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 331271005486 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 331271005487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271005488 dimer interface [polypeptide binding]; other site 331271005489 conserved gate region; other site 331271005490 putative PBP binding loops; other site 331271005491 ABC-ATPase subunit interface; other site 331271005492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271005493 dimer interface [polypeptide binding]; other site 331271005494 conserved gate region; other site 331271005495 putative PBP binding loops; other site 331271005496 ABC-ATPase subunit interface; other site 331271005497 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 331271005498 HAMP domain; Region: HAMP; pfam00672 331271005499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271005500 dimer interface [polypeptide binding]; other site 331271005501 phosphorylation site [posttranslational modification] 331271005502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271005503 ATP binding site [chemical binding]; other site 331271005504 Mg2+ binding site [ion binding]; other site 331271005505 G-X-G motif; other site 331271005506 osmolarity response regulator; Provisional; Region: ompR; PRK09468 331271005507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271005508 active site 331271005509 phosphorylation site [posttranslational modification] 331271005510 intermolecular recognition site; other site 331271005511 dimerization interface [polypeptide binding]; other site 331271005512 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271005513 DNA binding site [nucleotide binding] 331271005514 Heavy-metal resistance; Region: Metal_resist; pfam13801 331271005515 Mitochondrial ribosomal protein subunit L20; Region: MRP-L20; pfam12824 331271005516 Pirin-related protein [General function prediction only]; Region: COG1741 331271005517 Pirin; Region: Pirin; pfam02678 331271005518 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 331271005519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271005520 substrate binding pocket [chemical binding]; other site 331271005521 membrane-bound complex binding site; other site 331271005522 hinge residues; other site 331271005523 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271005524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271005525 dimer interface [polypeptide binding]; other site 331271005526 conserved gate region; other site 331271005527 putative PBP binding loops; other site 331271005528 ABC-ATPase subunit interface; other site 331271005529 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271005530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271005531 dimer interface [polypeptide binding]; other site 331271005532 conserved gate region; other site 331271005533 putative PBP binding loops; other site 331271005534 ABC-ATPase subunit interface; other site 331271005535 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 331271005536 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271005537 Walker A/P-loop; other site 331271005538 ATP binding site [chemical binding]; other site 331271005539 Q-loop/lid; other site 331271005540 ABC transporter signature motif; other site 331271005541 Walker B; other site 331271005542 D-loop; other site 331271005543 H-loop/switch region; other site 331271005544 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271005545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271005546 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 331271005547 putative substrate binding pocket [chemical binding]; other site 331271005548 dimerization interface [polypeptide binding]; other site 331271005549 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271005550 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271005551 trimer interface [polypeptide binding]; other site 331271005552 eyelet of channel; other site 331271005553 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 331271005554 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331271005555 NAD synthetase; Provisional; Region: PRK13981 331271005556 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 331271005557 multimer interface [polypeptide binding]; other site 331271005558 active site 331271005559 catalytic triad [active] 331271005560 protein interface 1 [polypeptide binding]; other site 331271005561 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 331271005562 homodimer interface [polypeptide binding]; other site 331271005563 NAD binding pocket [chemical binding]; other site 331271005564 ATP binding pocket [chemical binding]; other site 331271005565 Mg binding site [ion binding]; other site 331271005566 active-site loop [active] 331271005567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 331271005568 Protein of unknown function, DUF482; Region: DUF482; pfam04339 331271005569 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 331271005570 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 331271005571 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 331271005572 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 331271005573 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271005574 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271005575 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 331271005576 GIY-YIG motif/motif A; other site 331271005577 putative active site [active] 331271005578 putative metal binding site [ion binding]; other site 331271005579 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 331271005580 dimer interface [polypeptide binding]; other site 331271005581 substrate binding site [chemical binding]; other site 331271005582 metal binding sites [ion binding]; metal-binding site 331271005583 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271005584 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 331271005585 NAD(P) binding site [chemical binding]; other site 331271005586 catalytic residues [active] 331271005587 catalytic residues [active] 331271005588 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 331271005589 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 331271005590 putative NAD(P) binding site [chemical binding]; other site 331271005591 active site 331271005592 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271005593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271005594 putative substrate translocation pore; other site 331271005595 Helix-turn-helix domain; Region: HTH_17; pfam12728 331271005596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271005597 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 331271005598 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 331271005599 HemY protein N-terminus; Region: HemY_N; pfam07219 331271005600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271005601 TPR motif; other site 331271005602 binding surface 331271005603 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 331271005604 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 331271005605 active site 331271005606 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 331271005607 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 331271005608 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 331271005609 domain interfaces; other site 331271005610 active site 331271005611 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 331271005612 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 331271005613 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331271005614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271005615 S-adenosylmethionine binding site [chemical binding]; other site 331271005616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271005617 non-specific DNA binding site [nucleotide binding]; other site 331271005618 salt bridge; other site 331271005619 sequence-specific DNA binding site [nucleotide binding]; other site 331271005620 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271005621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 331271005622 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271005623 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271005624 argininosuccinate lyase; Provisional; Region: PRK00855 331271005625 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 331271005626 active sites [active] 331271005627 tetramer interface [polypeptide binding]; other site 331271005628 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 331271005629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271005630 motif II; other site 331271005631 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 331271005632 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 331271005633 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 331271005634 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 331271005635 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271005636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271005637 catalytic residue [active] 331271005638 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 331271005639 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 331271005640 trimer interface [polypeptide binding]; other site 331271005641 active site 331271005642 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 331271005643 E-class dimer interface [polypeptide binding]; other site 331271005644 P-class dimer interface [polypeptide binding]; other site 331271005645 active site 331271005646 Cu2+ binding site [ion binding]; other site 331271005647 Zn2+ binding site [ion binding]; other site 331271005648 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 331271005649 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331271005650 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271005651 ligand binding site [chemical binding]; other site 331271005652 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 331271005653 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 331271005654 active site 331271005655 HIGH motif; other site 331271005656 KMSKS motif; other site 331271005657 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 331271005658 tRNA binding surface [nucleotide binding]; other site 331271005659 anticodon binding site; other site 331271005660 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 331271005661 dimer interface [polypeptide binding]; other site 331271005662 putative tRNA-binding site [nucleotide binding]; other site 331271005663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 331271005664 Family of unknown function (DUF490); Region: DUF490; pfam04357 331271005665 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 331271005666 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331271005667 Surface antigen; Region: Bac_surface_Ag; pfam01103 331271005668 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 331271005669 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 331271005670 pantoate--beta-alanine ligase; Region: panC; TIGR00018 331271005671 Pantoate-beta-alanine ligase; Region: PanC; cd00560 331271005672 active site 331271005673 ATP-binding site [chemical binding]; other site 331271005674 pantoate-binding site; other site 331271005675 HXXH motif; other site 331271005676 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 331271005677 tetramerization interface [polypeptide binding]; other site 331271005678 active site 331271005679 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331271005680 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271005681 P-loop; other site 331271005682 Magnesium ion binding site [ion binding]; other site 331271005683 DoxX; Region: DoxX; pfam07681 331271005684 cobyric acid synthase; Provisional; Region: PRK00784 331271005685 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331271005686 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 331271005687 catalytic triad [active] 331271005688 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 331271005689 homotrimer interface [polypeptide binding]; other site 331271005690 Walker A motif; other site 331271005691 GTP binding site [chemical binding]; other site 331271005692 Walker B motif; other site 331271005693 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 331271005694 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 331271005695 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 331271005696 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271005697 catalytic residue [active] 331271005698 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 331271005699 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 331271005700 cobalamin binding residues [chemical binding]; other site 331271005701 putative BtuC binding residues; other site 331271005702 dimer interface [polypeptide binding]; other site 331271005703 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331271005704 catalytic core [active] 331271005705 cobalamin synthase; Reviewed; Region: cobS; PRK00235 331271005706 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 331271005707 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 331271005708 putative dimer interface [polypeptide binding]; other site 331271005709 active site pocket [active] 331271005710 putative cataytic base [active] 331271005711 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 331271005712 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 331271005713 Walker A/P-loop; other site 331271005714 ATP binding site [chemical binding]; other site 331271005715 Q-loop/lid; other site 331271005716 ABC transporter signature motif; other site 331271005717 Walker B; other site 331271005718 D-loop; other site 331271005719 H-loop/switch region; other site 331271005720 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 331271005721 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331271005722 ABC-ATPase subunit interface; other site 331271005723 dimer interface [polypeptide binding]; other site 331271005724 putative PBP binding regions; other site 331271005725 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 331271005726 Cell division protein ZapA; Region: ZapA; pfam05164 331271005727 EVE domain; Region: EVE; cl00728 331271005728 Protein of unknown function (DUF541); Region: SIMPL; cl01077 331271005729 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 331271005730 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 331271005731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271005732 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 331271005733 putative dimerization interface [polypeptide binding]; other site 331271005734 putative substrate binding pocket [chemical binding]; other site 331271005735 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 331271005736 Cytochrome c; Region: Cytochrom_C; cl11414 331271005737 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 331271005738 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 331271005739 multifunctional aminopeptidase A; Provisional; Region: PRK00913 331271005740 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 331271005741 interface (dimer of trimers) [polypeptide binding]; other site 331271005742 Substrate-binding/catalytic site; other site 331271005743 Zn-binding sites [ion binding]; other site 331271005744 Predicted permeases [General function prediction only]; Region: COG0795 331271005745 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331271005746 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 331271005747 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331271005748 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 331271005749 putative active site [active] 331271005750 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 331271005751 active site 331271005752 SAM binding site [chemical binding]; other site 331271005753 homodimer interface [polypeptide binding]; other site 331271005754 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 331271005755 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 331271005756 CysD dimerization site [polypeptide binding]; other site 331271005757 G1 box; other site 331271005758 putative GEF interaction site [polypeptide binding]; other site 331271005759 GTP/Mg2+ binding site [chemical binding]; other site 331271005760 Switch I region; other site 331271005761 G2 box; other site 331271005762 G3 box; other site 331271005763 Switch II region; other site 331271005764 G4 box; other site 331271005765 G5 box; other site 331271005766 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 331271005767 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 331271005768 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 331271005769 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 331271005770 Active Sites [active] 331271005771 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 331271005772 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 331271005773 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 331271005774 Active Sites [active] 331271005775 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 331271005776 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 331271005777 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331271005778 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331271005779 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 331271005780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271005781 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 331271005782 substrate binding site [chemical binding]; other site 331271005783 dimerization interface [polypeptide binding]; other site 331271005784 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271005785 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 331271005786 putative ligand binding site [chemical binding]; other site 331271005787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271005788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271005789 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271005790 putative effector binding pocket; other site 331271005791 dimerization interface [polypeptide binding]; other site 331271005792 short chain dehydrogenase; Provisional; Region: PRK12937 331271005793 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 331271005794 NADP binding site [chemical binding]; other site 331271005795 homodimer interface [polypeptide binding]; other site 331271005796 active site 331271005797 substrate binding site [chemical binding]; other site 331271005798 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271005799 NADP binding site [chemical binding]; other site 331271005800 active site 331271005801 steroid binding site; other site 331271005802 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271005803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271005804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271005805 dimerization interface [polypeptide binding]; other site 331271005806 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271005807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271005808 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271005809 putative effector binding pocket; other site 331271005810 putative dimerization interface [polypeptide binding]; other site 331271005811 short chain dehydrogenase; Provisional; Region: PRK12744 331271005812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271005813 NAD(P) binding site [chemical binding]; other site 331271005814 active site 331271005815 DinB superfamily; Region: DinB_2; pfam12867 331271005816 CopC domain; Region: CopC; pfam04234 331271005817 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 331271005818 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 331271005819 active site 331271005820 uracil binding [chemical binding]; other site 331271005821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271005822 NAD(P) binding site [chemical binding]; other site 331271005823 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271005824 active site 331271005825 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 331271005826 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271005827 catalytic loop [active] 331271005828 iron binding site [ion binding]; other site 331271005829 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 331271005830 FAD binding pocket [chemical binding]; other site 331271005831 FAD binding motif [chemical binding]; other site 331271005832 phosphate binding motif [ion binding]; other site 331271005833 beta-alpha-beta structure motif; other site 331271005834 NAD binding pocket [chemical binding]; other site 331271005835 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 331271005836 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271005837 inhibitor-cofactor binding pocket; inhibition site 331271005838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271005839 catalytic residue [active] 331271005840 putative acetyltransferase; Provisional; Region: PRK03624 331271005841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271005842 Coenzyme A binding pocket [chemical binding]; other site 331271005843 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 331271005844 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331271005845 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271005846 Walker A/P-loop; other site 331271005847 ATP binding site [chemical binding]; other site 331271005848 Q-loop/lid; other site 331271005849 ABC transporter signature motif; other site 331271005850 Walker B; other site 331271005851 D-loop; other site 331271005852 H-loop/switch region; other site 331271005853 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331271005854 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271005855 Walker A/P-loop; other site 331271005856 ATP binding site [chemical binding]; other site 331271005857 Q-loop/lid; other site 331271005858 ABC transporter signature motif; other site 331271005859 Walker B; other site 331271005860 D-loop; other site 331271005861 H-loop/switch region; other site 331271005862 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271005863 TM-ABC transporter signature motif; other site 331271005864 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271005865 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271005866 TM-ABC transporter signature motif; other site 331271005867 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 331271005868 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 331271005869 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 331271005870 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 331271005871 hypothetical protein; Reviewed; Region: PRK00024 331271005872 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 331271005873 MPN+ (JAMM) motif; other site 331271005874 Zinc-binding site [ion binding]; other site 331271005875 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 331271005876 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 331271005877 L-aspartate oxidase; Provisional; Region: PRK09077 331271005878 L-aspartate oxidase; Provisional; Region: PRK06175 331271005879 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331271005880 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 331271005881 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 331271005882 dimerization interface [polypeptide binding]; other site 331271005883 active site 331271005884 quinolinate synthetase; Provisional; Region: PRK09375 331271005885 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 331271005886 Fatty acid desaturase; Region: FA_desaturase; pfam00487 331271005887 Di-iron ligands [ion binding]; other site 331271005888 Transposase; Region: DDE_Tnp_ISL3; pfam01610 331271005889 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331271005890 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271005891 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 331271005892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271005893 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 331271005894 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 331271005895 active site 331271005896 substrate binding site [chemical binding]; other site 331271005897 cosubstrate binding site; other site 331271005898 catalytic site [active] 331271005899 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 331271005900 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 331271005901 active site 331271005902 Riboflavin kinase; Region: Flavokinase; smart00904 331271005903 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 331271005904 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331271005905 active site 331271005906 HIGH motif; other site 331271005907 nucleotide binding site [chemical binding]; other site 331271005908 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 331271005909 active site 331271005910 KMSKS motif; other site 331271005911 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 331271005912 tRNA binding surface [nucleotide binding]; other site 331271005913 anticodon binding site; other site 331271005914 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 331271005915 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 331271005916 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 331271005917 Flavoprotein; Region: Flavoprotein; pfam02441 331271005918 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 331271005919 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 331271005920 trimer interface [polypeptide binding]; other site 331271005921 active site 331271005922 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 331271005923 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 331271005924 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 331271005925 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 331271005926 Clp amino terminal domain; Region: Clp_N; pfam02861 331271005927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271005928 Walker A motif; other site 331271005929 ATP binding site [chemical binding]; other site 331271005930 Walker B motif; other site 331271005931 arginine finger; other site 331271005932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271005933 Walker A motif; other site 331271005934 ATP binding site [chemical binding]; other site 331271005935 Walker B motif; other site 331271005936 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 331271005937 Uncharacterized conserved protein [Function unknown]; Region: COG2127 331271005938 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 331271005939 DNA-binding site [nucleotide binding]; DNA binding site 331271005940 RNA-binding motif; other site 331271005941 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 331271005942 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 331271005943 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 331271005944 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 331271005945 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 331271005946 isocitrate dehydrogenase; Validated; Region: PRK07362 331271005947 isocitrate dehydrogenase; Reviewed; Region: PRK07006 331271005948 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 331271005949 pseudouridine synthase; Region: TIGR00093 331271005950 active site 331271005951 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 331271005952 elongation factor G; Reviewed; Region: PRK00007 331271005953 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 331271005954 G1 box; other site 331271005955 putative GEF interaction site [polypeptide binding]; other site 331271005956 GTP/Mg2+ binding site [chemical binding]; other site 331271005957 Switch I region; other site 331271005958 G2 box; other site 331271005959 G3 box; other site 331271005960 Switch II region; other site 331271005961 G4 box; other site 331271005962 G5 box; other site 331271005963 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 331271005964 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 331271005965 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 331271005966 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 331271005967 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271005968 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271005969 active site 331271005970 catalytic tetrad [active] 331271005971 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 331271005972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271005973 DNA-binding site [nucleotide binding]; DNA binding site 331271005974 UTRA domain; Region: UTRA; pfam07702 331271005975 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271005976 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271005977 MerR family regulatory protein; Region: MerR; pfam00376 331271005978 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 331271005979 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 331271005980 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 331271005981 dimer interface [polypeptide binding]; other site 331271005982 active site 331271005983 oxalacetate/citrate binding site [chemical binding]; other site 331271005984 citrylCoA binding site [chemical binding]; other site 331271005985 coenzyme A binding site [chemical binding]; other site 331271005986 catalytic triad [active] 331271005987 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 331271005988 putative transporter; Provisional; Region: PRK10504 331271005989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271005990 putative substrate translocation pore; other site 331271005991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271005992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331271005993 S-adenosylmethionine binding site [chemical binding]; other site 331271005994 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 331271005995 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 331271005996 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 331271005997 Predicted membrane protein [Function unknown]; Region: COG4539 331271005998 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 331271005999 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271006000 ligand binding site [chemical binding]; other site 331271006001 flexible hinge region; other site 331271006002 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 331271006003 putative switch regulator; other site 331271006004 non-specific DNA interactions [nucleotide binding]; other site 331271006005 DNA binding site [nucleotide binding] 331271006006 sequence specific DNA binding site [nucleotide binding]; other site 331271006007 putative cAMP binding site [chemical binding]; other site 331271006008 Chromate transporter; Region: Chromate_transp; cl17781 331271006009 Chromate transporter; Region: Chromate_transp; pfam02417 331271006010 superoxide dismutase; Provisional; Region: PRK10543 331271006011 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 331271006012 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 331271006013 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 331271006014 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 331271006015 generic binding surface II; other site 331271006016 generic binding surface I; other site 331271006017 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 331271006018 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 331271006019 Uncharacterized conserved protein [Function unknown]; Region: COG2835 331271006020 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 331271006021 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 331271006022 Ligand binding site; other site 331271006023 oligomer interface; other site 331271006024 adenylate kinase; Reviewed; Region: adk; PRK00279 331271006025 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 331271006026 AMP-binding site [chemical binding]; other site 331271006027 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 331271006028 Uncharacterized conserved protein [Function unknown]; Region: COG2912 331271006029 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 331271006030 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 331271006031 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 331271006032 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 331271006033 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 331271006034 ornithine carbamoyltransferase; Provisional; Region: PRK00779 331271006035 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 331271006036 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 331271006037 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 331271006038 FAD binding domain; Region: FAD_binding_4; pfam01565 331271006039 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 331271006040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 331271006041 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 331271006042 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 331271006043 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 331271006044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271006045 acyl-activating enzyme (AAE) consensus motif; other site 331271006046 AMP binding site [chemical binding]; other site 331271006047 active site 331271006048 CoA binding site [chemical binding]; other site 331271006049 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 331271006050 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 331271006051 active site 331271006052 Int/Topo IB signature motif; other site 331271006053 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 331271006054 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 331271006055 DNA binding site [nucleotide binding] 331271006056 active site 331271006057 epoxyqueuosine reductase; Region: TIGR00276 331271006058 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 331271006059 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 331271006060 AMIN domain; Region: AMIN; pfam11741 331271006061 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 331271006062 active site 331271006063 metal binding site [ion binding]; metal-binding site 331271006064 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 331271006065 EamA-like transporter family; Region: EamA; pfam00892 331271006066 Pirin-related protein [General function prediction only]; Region: COG1741 331271006067 Pirin; Region: Pirin; pfam02678 331271006068 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 331271006069 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 331271006070 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331271006071 catalytic residues [active] 331271006072 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 331271006073 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 331271006074 putative ATP binding site [chemical binding]; other site 331271006075 putative substrate interface [chemical binding]; other site 331271006076 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 331271006077 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 331271006078 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 331271006079 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 331271006080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271006081 S-adenosylmethionine binding site [chemical binding]; other site 331271006082 Protein of unknown function DUF72; Region: DUF72; pfam01904 331271006083 methionine sulfoxide reductase A; Provisional; Region: PRK14054 331271006084 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 331271006085 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 331271006086 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271006087 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271006088 putative DNA binding site [nucleotide binding]; other site 331271006089 putative Zn2+ binding site [ion binding]; other site 331271006090 AsnC family; Region: AsnC_trans_reg; pfam01037 331271006091 arylformamidase; Region: trp_arylform; TIGR03035 331271006092 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 331271006093 kynureninase; Region: kynureninase; TIGR01814 331271006094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271006095 catalytic residue [active] 331271006096 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 331271006097 benzoate transport; Region: 2A0115; TIGR00895 331271006098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271006099 putative substrate translocation pore; other site 331271006100 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 331271006101 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 331271006102 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 331271006103 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 331271006104 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 331271006105 NAD(P) binding site [chemical binding]; other site 331271006106 catalytic residues [active] 331271006107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271006108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271006109 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 331271006110 putative dimerization interface [polypeptide binding]; other site 331271006111 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 331271006112 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 331271006113 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 331271006114 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 331271006115 N- and C-terminal domain interface [polypeptide binding]; other site 331271006116 D-xylulose kinase; Region: XylB; TIGR01312 331271006117 active site 331271006118 MgATP binding site [chemical binding]; other site 331271006119 catalytic site [active] 331271006120 metal binding site [ion binding]; metal-binding site 331271006121 xylulose binding site [chemical binding]; other site 331271006122 homodimer interface [polypeptide binding]; other site 331271006123 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 331271006124 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 331271006125 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271006126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271006127 putative substrate translocation pore; other site 331271006128 Beta-lactamase; Region: Beta-lactamase; pfam00144 331271006129 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 331271006130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271006131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271006132 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 331271006133 putative effector binding pocket; other site 331271006134 putative dimerization interface [polypeptide binding]; other site 331271006135 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 331271006136 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 331271006137 Walker A/P-loop; other site 331271006138 ATP binding site [chemical binding]; other site 331271006139 Q-loop/lid; other site 331271006140 ABC transporter signature motif; other site 331271006141 Walker B; other site 331271006142 D-loop; other site 331271006143 H-loop/switch region; other site 331271006144 TOBE domain; Region: TOBE; pfam03459 331271006145 TOBE domain; Region: TOBE_2; pfam08402 331271006146 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 331271006147 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271006148 motif II; other site 331271006149 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271006150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271006151 dimer interface [polypeptide binding]; other site 331271006152 conserved gate region; other site 331271006153 putative PBP binding loops; other site 331271006154 ABC-ATPase subunit interface; other site 331271006155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271006156 dimer interface [polypeptide binding]; other site 331271006157 conserved gate region; other site 331271006158 putative PBP binding loops; other site 331271006159 ABC-ATPase subunit interface; other site 331271006160 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 331271006161 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271006162 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 331271006163 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 331271006164 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271006165 substrate binding site [chemical binding]; other site 331271006166 ATP binding site [chemical binding]; other site 331271006167 sorbitol dehydrogenase; Provisional; Region: PRK07067 331271006168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271006169 NAD(P) binding site [chemical binding]; other site 331271006170 active site 331271006171 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331271006172 metal binding site 2 [ion binding]; metal-binding site 331271006173 putative DNA binding helix; other site 331271006174 metal binding site 1 [ion binding]; metal-binding site 331271006175 dimer interface [polypeptide binding]; other site 331271006176 structural Zn2+ binding site [ion binding]; other site 331271006177 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 331271006178 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 331271006179 metal binding site [ion binding]; metal-binding site 331271006180 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 331271006181 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 331271006182 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 331271006183 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 331271006184 ABC-ATPase subunit interface; other site 331271006185 dimer interface [polypeptide binding]; other site 331271006186 S-formylglutathione hydrolase; Region: PLN02442 331271006187 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 331271006188 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 331271006189 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 331271006190 substrate binding site [chemical binding]; other site 331271006191 catalytic Zn binding site [ion binding]; other site 331271006192 NAD binding site [chemical binding]; other site 331271006193 structural Zn binding site [ion binding]; other site 331271006194 dimer interface [polypeptide binding]; other site 331271006195 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 331271006196 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 331271006197 nucleotide binding site [chemical binding]; other site 331271006198 xanthine permease; Region: pbuX; TIGR03173 331271006199 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 331271006200 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 331271006201 Protein export membrane protein; Region: SecD_SecF; cl14618 331271006202 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 331271006203 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 331271006204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271006205 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271006206 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 331271006207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271006208 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 331271006209 Isochorismatase family; Region: Isochorismatase; pfam00857 331271006210 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 331271006211 catalytic triad [active] 331271006212 conserved cis-peptide bond; other site 331271006213 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 331271006214 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271006215 conserved cys residue [active] 331271006216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271006217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271006218 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331271006219 hydrophobic ligand binding site; other site 331271006220 Domain of unknown function (DUF427); Region: DUF427; pfam04248 331271006221 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 331271006222 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 331271006223 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 331271006224 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331271006225 protein binding site [polypeptide binding]; other site 331271006226 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331271006227 protein binding site [polypeptide binding]; other site 331271006228 sensor protein QseC; Provisional; Region: PRK10337 331271006229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271006230 dimer interface [polypeptide binding]; other site 331271006231 phosphorylation site [posttranslational modification] 331271006232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271006233 ATP binding site [chemical binding]; other site 331271006234 Mg2+ binding site [ion binding]; other site 331271006235 G-X-G motif; other site 331271006236 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 331271006237 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 331271006238 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 331271006239 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 331271006240 active site 331271006241 catalytic triad [active] 331271006242 oxyanion hole [active] 331271006243 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 331271006244 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 331271006245 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 331271006246 ATP-grasp domain; Region: ATP-grasp; pfam02222 331271006247 AIR carboxylase; Region: AIRC; pfam00731 331271006248 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 331271006249 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 331271006250 ATP binding site [chemical binding]; other site 331271006251 active site 331271006252 substrate binding site [chemical binding]; other site 331271006253 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 331271006254 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 331271006255 intersubunit interface [polypeptide binding]; other site 331271006256 active site 331271006257 zinc binding site [ion binding]; other site 331271006258 Na+ binding site [ion binding]; other site 331271006259 pyruvate kinase; Provisional; Region: PRK05826 331271006260 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 331271006261 domain interfaces; other site 331271006262 active site 331271006263 Phosphoglycerate kinase; Region: PGK; pfam00162 331271006264 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 331271006265 substrate binding site [chemical binding]; other site 331271006266 hinge regions; other site 331271006267 ADP binding site [chemical binding]; other site 331271006268 catalytic site [active] 331271006269 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 331271006270 AzlC protein; Region: AzlC; cl00570 331271006271 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 331271006272 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 331271006273 homodimer interface [polypeptide binding]; other site 331271006274 substrate-cofactor binding pocket; other site 331271006275 catalytic residue [active] 331271006276 Zinc-finger domain; Region: zf-CHCC; cl01821 331271006277 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331271006278 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331271006279 putative active site [active] 331271006280 SnoaL-like domain; Region: SnoaL_3; pfam13474 331271006281 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 331271006282 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 331271006283 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 331271006284 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 331271006285 Peptidase family M48; Region: Peptidase_M48; pfam01435 331271006286 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 331271006287 trimer interface [polypeptide binding]; other site 331271006288 dimer interface [polypeptide binding]; other site 331271006289 putative active site [active] 331271006290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 331271006291 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 331271006292 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 331271006293 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 331271006294 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 331271006295 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 331271006296 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 331271006297 O-Antigen ligase; Region: Wzy_C; pfam04932 331271006298 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 331271006299 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 331271006300 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 331271006301 Pilin (bacterial filament); Region: Pilin; pfam00114 331271006302 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 331271006303 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 331271006304 CoA binding domain; Region: CoA_binding; smart00881 331271006305 CoA-ligase; Region: Ligase_CoA; pfam00549 331271006306 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 331271006307 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 331271006308 CoA-ligase; Region: Ligase_CoA; pfam00549 331271006309 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 331271006310 recombination regulator RecX; Provisional; Region: recX; PRK14136 331271006311 recombinase A; Provisional; Region: recA; PRK09354 331271006312 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 331271006313 hexamer interface [polypeptide binding]; other site 331271006314 Walker A motif; other site 331271006315 ATP binding site [chemical binding]; other site 331271006316 Walker B motif; other site 331271006317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271006318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271006319 active site 331271006320 phosphorylation site [posttranslational modification] 331271006321 intermolecular recognition site; other site 331271006322 dimerization interface [polypeptide binding]; other site 331271006323 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271006324 DNA binding site [nucleotide binding] 331271006325 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 331271006326 HAMP domain; Region: HAMP; pfam00672 331271006327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271006328 dimer interface [polypeptide binding]; other site 331271006329 phosphorylation site [posttranslational modification] 331271006330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271006331 ATP binding site [chemical binding]; other site 331271006332 Mg2+ binding site [ion binding]; other site 331271006333 G-X-G motif; other site 331271006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271006335 putative substrate translocation pore; other site 331271006336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271006337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271006338 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271006339 putative effector binding pocket; other site 331271006340 putative dimerization interface [polypeptide binding]; other site 331271006341 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271006342 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271006343 conserved cys residue [active] 331271006344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271006345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271006346 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 331271006347 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 331271006348 conserved cys residue [active] 331271006349 Cupin domain; Region: Cupin_2; cl17218 331271006350 PAAR motif; Region: PAAR_motif; pfam05488 331271006351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271006352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271006353 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271006354 putative effector binding pocket; other site 331271006355 dimerization interface [polypeptide binding]; other site 331271006356 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 331271006357 Transglycosylase; Region: Transgly; cl17702 331271006358 Uncharacterized conserved protein [Function unknown]; Region: COG3791 331271006359 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 331271006360 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 331271006361 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271006362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271006363 DNA-binding site [nucleotide binding]; DNA binding site 331271006364 FCD domain; Region: FCD; pfam07729 331271006365 galactonate dehydratase; Provisional; Region: PRK14017 331271006366 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 331271006367 putative active site pocket [active] 331271006368 putative metal binding site [ion binding]; other site 331271006369 Copper resistance protein D; Region: CopD; pfam05425 331271006370 Cytochrome c; Region: Cytochrom_C; cl11414 331271006371 Cytochrome c; Region: Cytochrom_C; cl11414 331271006372 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271006373 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271006374 Cytochrome c; Region: Cytochrom_C; pfam00034 331271006375 helicase 45; Provisional; Region: PTZ00424 331271006376 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331271006377 ATP binding site [chemical binding]; other site 331271006378 Mg++ binding site [ion binding]; other site 331271006379 motif III; other site 331271006380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271006381 nucleotide binding region [chemical binding]; other site 331271006382 ATP-binding site [chemical binding]; other site 331271006383 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 331271006384 dinuclear metal binding motif [ion binding]; other site 331271006385 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 331271006386 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 331271006387 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 331271006388 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 331271006389 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 331271006390 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 331271006391 glycerol kinase; Provisional; Region: glpK; PRK00047 331271006392 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 331271006393 N- and C-terminal domain interface [polypeptide binding]; other site 331271006394 active site 331271006395 MgATP binding site [chemical binding]; other site 331271006396 catalytic site [active] 331271006397 metal binding site [ion binding]; metal-binding site 331271006398 glycerol binding site [chemical binding]; other site 331271006399 homotetramer interface [polypeptide binding]; other site 331271006400 homodimer interface [polypeptide binding]; other site 331271006401 FBP binding site [chemical binding]; other site 331271006402 protein IIAGlc interface [polypeptide binding]; other site 331271006403 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 331271006404 amphipathic channel; other site 331271006405 Asn-Pro-Ala signature motifs; other site 331271006406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 331271006407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271006408 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 331271006409 [2Fe-2S] cluster binding site [ion binding]; other site 331271006410 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 331271006411 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 331271006412 putative di-iron ligands [ion binding]; other site 331271006413 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271006414 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 331271006415 putative ligand binding site [chemical binding]; other site 331271006416 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271006417 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 331271006418 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 331271006419 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 331271006420 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 331271006421 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 331271006422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271006423 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 331271006424 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 331271006425 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271006426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271006427 non-specific DNA binding site [nucleotide binding]; other site 331271006428 salt bridge; other site 331271006429 sequence-specific DNA binding site [nucleotide binding]; other site 331271006430 Cupin domain; Region: Cupin_2; pfam07883 331271006431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271006432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271006433 putative substrate translocation pore; other site 331271006434 transcriptional regulator; Provisional; Region: PRK10632 331271006435 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271006436 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271006437 putative effector binding pocket; other site 331271006438 dimerization interface [polypeptide binding]; other site 331271006439 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 331271006440 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331271006441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271006442 FeS/SAM binding site; other site 331271006443 TRAM domain; Region: TRAM; pfam01938 331271006444 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 331271006445 PhoH-like protein; Region: PhoH; pfam02562 331271006446 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 331271006447 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 331271006448 putative active site pocket [active] 331271006449 dimerization interface [polypeptide binding]; other site 331271006450 putative catalytic residue [active] 331271006451 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 331271006452 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331271006453 Transporter associated domain; Region: CorC_HlyC; smart01091 331271006454 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 331271006455 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 331271006456 putative active site [active] 331271006457 catalytic triad [active] 331271006458 putative dimer interface [polypeptide binding]; other site 331271006459 TPR repeat; Region: TPR_11; pfam13414 331271006460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271006461 binding surface 331271006462 TPR motif; other site 331271006463 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271006464 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 331271006465 dimer interface [polypeptide binding]; other site 331271006466 motif 1; other site 331271006467 active site 331271006468 motif 2; other site 331271006469 motif 3; other site 331271006470 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 331271006471 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331271006472 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 331271006473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271006474 active site 331271006475 motif I; other site 331271006476 motif II; other site 331271006477 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331271006478 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331271006479 putative acyl-acceptor binding pocket; other site 331271006480 Protein of unknown function DUF45; Region: DUF45; pfam01863 331271006481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271006482 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 331271006483 dimer interface [polypeptide binding]; other site 331271006484 active site 331271006485 metal binding site [ion binding]; metal-binding site 331271006486 glutathione binding site [chemical binding]; other site 331271006487 EamA-like transporter family; Region: EamA; pfam00892 331271006488 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 331271006489 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 331271006490 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 331271006491 SurA N-terminal domain; Region: SurA_N; pfam09312 331271006492 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 331271006493 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 331271006494 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 331271006495 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 331271006496 Organic solvent tolerance protein; Region: OstA_C; pfam04453 331271006497 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 331271006498 Phosphotransferase enzyme family; Region: APH; pfam01636 331271006499 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 331271006500 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 331271006501 Substrate binding site; other site 331271006502 metal-binding site 331271006503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271006504 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 331271006505 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 331271006506 Walker A/P-loop; other site 331271006507 ATP binding site [chemical binding]; other site 331271006508 Q-loop/lid; other site 331271006509 ABC transporter signature motif; other site 331271006510 Walker B; other site 331271006511 D-loop; other site 331271006512 H-loop/switch region; other site 331271006513 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 331271006514 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 331271006515 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 331271006516 enoyl-CoA hydratase; Provisional; Region: PRK06688 331271006517 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271006518 substrate binding site [chemical binding]; other site 331271006519 oxyanion hole (OAH) forming residues; other site 331271006520 trimer interface [polypeptide binding]; other site 331271006521 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 331271006522 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 331271006523 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271006524 dimer interface [polypeptide binding]; other site 331271006525 active site 331271006526 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 331271006527 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271006528 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271006529 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 331271006530 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271006531 substrate binding site [chemical binding]; other site 331271006532 oxyanion hole (OAH) forming residues; other site 331271006533 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 331271006534 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 331271006535 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 331271006536 FAD binding site [chemical binding]; other site 331271006537 substrate binding site [chemical binding]; other site 331271006538 catalytic residues [active] 331271006539 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 331271006540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271006541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271006542 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 331271006543 PLD-like domain; Region: PLDc_2; pfam13091 331271006544 putative active site [active] 331271006545 catalytic site [active] 331271006546 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 331271006547 PLD-like domain; Region: PLDc_2; pfam13091 331271006548 putative active site [active] 331271006549 catalytic site [active] 331271006550 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 331271006551 nudix motif; other site 331271006552 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 331271006553 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 331271006554 dimer interface [polypeptide binding]; other site 331271006555 anticodon binding site; other site 331271006556 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 331271006557 homodimer interface [polypeptide binding]; other site 331271006558 motif 1; other site 331271006559 active site 331271006560 motif 2; other site 331271006561 GAD domain; Region: GAD; pfam02938 331271006562 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 331271006563 motif 3; other site 331271006564 Uncharacterized conserved protein [Function unknown]; Region: COG2928 331271006565 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 331271006566 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 331271006567 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 331271006568 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 331271006569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 331271006570 SCP-2 sterol transfer family; Region: SCP2; pfam02036 331271006571 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 331271006572 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 331271006573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271006574 S-adenosylmethionine binding site [chemical binding]; other site 331271006575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 331271006576 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 331271006577 nucleotide binding site/active site [active] 331271006578 HIT family signature motif; other site 331271006579 catalytic residue [active] 331271006580 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 331271006581 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331271006582 FAD binding domain; Region: FAD_binding_4; pfam01565 331271006583 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331271006584 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 331271006585 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331271006586 Cysteine-rich domain; Region: CCG; pfam02754 331271006587 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 331271006588 threonine dehydratase; Reviewed; Region: PRK09224 331271006589 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 331271006590 tetramer interface [polypeptide binding]; other site 331271006591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271006592 catalytic residue [active] 331271006593 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 331271006594 putative Ile/Val binding site [chemical binding]; other site 331271006595 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 331271006596 putative Ile/Val binding site [chemical binding]; other site 331271006597 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 331271006598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 331271006599 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 331271006600 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 331271006601 dimer interface [polypeptide binding]; other site 331271006602 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271006603 ligand binding site [chemical binding]; other site 331271006604 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 331271006605 homotrimer interaction site [polypeptide binding]; other site 331271006606 putative active site [active] 331271006607 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 331271006608 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 331271006609 active site 331271006610 putative substrate binding pocket [chemical binding]; other site 331271006611 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 331271006612 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271006613 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 331271006614 putative active site [active] 331271006615 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 331271006616 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 331271006617 dimer interface [polypeptide binding]; other site 331271006618 active site 331271006619 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331271006620 substrate binding site [chemical binding]; other site 331271006621 catalytic residue [active] 331271006622 intracellular protease, PfpI family; Region: PfpI; TIGR01382 331271006623 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 331271006624 conserved cys residue [active] 331271006625 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271006626 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 331271006627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271006628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271006629 putative substrate translocation pore; other site 331271006630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271006631 EcsC protein family; Region: EcsC; pfam12787 331271006632 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271006633 CHRD domain; Region: CHRD; pfam07452 331271006634 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 331271006635 aldolase II superfamily protein; Provisional; Region: PRK07044 331271006636 intersubunit interface [polypeptide binding]; other site 331271006637 active site 331271006638 Zn2+ binding site [ion binding]; other site 331271006639 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 331271006640 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 331271006641 putative active site [active] 331271006642 catalytic site [active] 331271006643 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 331271006644 putative active site [active] 331271006645 catalytic site [active] 331271006646 Type III secretion protein (HpaP); Region: HpaP; cl17849 331271006647 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 331271006648 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 331271006649 homotrimer interaction site [polypeptide binding]; other site 331271006650 putative active site [active] 331271006651 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331271006652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271006653 NAD(P) binding site [chemical binding]; other site 331271006654 active site 331271006655 acyl carrier protein; Provisional; Region: PRK09184 331271006656 Predicted membrane protein [Function unknown]; Region: COG4648 331271006657 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 331271006658 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271006659 acyl-activating enzyme (AAE) consensus motif; other site 331271006660 AMP binding site [chemical binding]; other site 331271006661 active site 331271006662 CoA binding site [chemical binding]; other site 331271006663 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 331271006664 putative acyl-acceptor binding pocket; other site 331271006665 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 331271006666 Predicted exporter [General function prediction only]; Region: COG4258 331271006667 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 331271006668 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 331271006669 NodB motif; other site 331271006670 active site 331271006671 catalytic site [active] 331271006672 metal binding site [ion binding]; metal-binding site 331271006673 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 331271006674 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 331271006675 dimer interface [polypeptide binding]; other site 331271006676 active site 331271006677 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 331271006678 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 331271006679 putative active site 1 [active] 331271006680 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 331271006681 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 331271006682 NAD(P) binding site [chemical binding]; other site 331271006683 homotetramer interface [polypeptide binding]; other site 331271006684 homodimer interface [polypeptide binding]; other site 331271006685 active site 331271006686 putative acyltransferase; Provisional; Region: PRK05790 331271006687 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271006688 dimer interface [polypeptide binding]; other site 331271006689 active site 331271006690 Phasin protein; Region: Phasin_2; pfam09361 331271006691 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331271006692 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271006693 P-loop; other site 331271006694 Magnesium ion binding site [ion binding]; other site 331271006695 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271006696 Magnesium ion binding site [ion binding]; other site 331271006697 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 331271006698 active site 331271006699 DNA binding site [nucleotide binding] 331271006700 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 331271006701 active site 331271006702 SUMO-1 interface [polypeptide binding]; other site 331271006703 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 331271006704 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 331271006705 dimer interface [polypeptide binding]; other site 331271006706 ssDNA binding site [nucleotide binding]; other site 331271006707 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331271006708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271006709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271006710 putative substrate translocation pore; other site 331271006711 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 331271006712 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331271006713 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331271006714 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 331271006715 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 331271006716 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 331271006717 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 331271006718 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 331271006719 putative active site [active] 331271006720 putative substrate binding site [chemical binding]; other site 331271006721 putative cosubstrate binding site; other site 331271006722 catalytic site [active] 331271006723 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 331271006724 nudix motif; other site 331271006725 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271006726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271006727 active site 331271006728 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 331271006729 TrkA-N domain; Region: TrkA_N; pfam02254 331271006730 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 331271006731 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 331271006732 putative active site [active] 331271006733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 331271006734 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 331271006735 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 331271006736 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 331271006737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 331271006738 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 331271006739 OstA-like protein; Region: OstA; pfam03968 331271006740 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 331271006741 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 331271006742 Walker A/P-loop; other site 331271006743 ATP binding site [chemical binding]; other site 331271006744 Q-loop/lid; other site 331271006745 ABC transporter signature motif; other site 331271006746 Walker B; other site 331271006747 D-loop; other site 331271006748 H-loop/switch region; other site 331271006749 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 331271006750 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 331271006751 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 331271006752 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 331271006753 30S subunit binding site; other site 331271006754 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 331271006755 active site 331271006756 phosphorylation site [posttranslational modification] 331271006757 HPr kinase/phosphorylase; Provisional; Region: PRK05428 331271006758 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 331271006759 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 331271006760 Hpr binding site; other site 331271006761 active site 331271006762 homohexamer subunit interaction site [polypeptide binding]; other site 331271006763 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 331271006764 AAA domain; Region: AAA_18; pfam13238 331271006765 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 331271006766 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 331271006767 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331271006768 minor groove reading motif; other site 331271006769 helix-hairpin-helix signature motif; other site 331271006770 substrate binding pocket [chemical binding]; other site 331271006771 active site 331271006772 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 331271006773 DNA binding and oxoG recognition site [nucleotide binding] 331271006774 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 331271006775 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 331271006776 DNA binding site [nucleotide binding] 331271006777 catalytic residue [active] 331271006778 H2TH interface [polypeptide binding]; other site 331271006779 putative catalytic residues [active] 331271006780 turnover-facilitating residue; other site 331271006781 intercalation triad [nucleotide binding]; other site 331271006782 8OG recognition residue [nucleotide binding]; other site 331271006783 putative reading head residues; other site 331271006784 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 331271006785 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 331271006786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271006787 binding surface 331271006788 TPR motif; other site 331271006789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271006790 TPR motif; other site 331271006791 binding surface 331271006792 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 331271006793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271006794 binding surface 331271006795 TPR motif; other site 331271006796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271006797 binding surface 331271006798 TPR motif; other site 331271006799 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 331271006800 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 331271006801 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 331271006802 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 331271006803 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 331271006804 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 331271006805 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271006806 active site 331271006807 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 331271006808 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 331271006809 5S rRNA interface [nucleotide binding]; other site 331271006810 CTC domain interface [polypeptide binding]; other site 331271006811 L16 interface [polypeptide binding]; other site 331271006812 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 331271006813 putative active site [active] 331271006814 catalytic residue [active] 331271006815 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 331271006816 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271006817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271006818 homodimer interface [polypeptide binding]; other site 331271006819 catalytic residue [active] 331271006820 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 331271006821 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 331271006822 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 331271006823 active site 331271006824 (T/H)XGH motif; other site 331271006825 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 331271006826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271006827 S-adenosylmethionine binding site [chemical binding]; other site 331271006828 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 331271006829 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 331271006830 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 331271006831 P loop; other site 331271006832 GTP binding site [chemical binding]; other site 331271006833 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 331271006834 maleylacetoacetate isomerase; Region: maiA; TIGR01262 331271006835 C-terminal domain interface [polypeptide binding]; other site 331271006836 GSH binding site (G-site) [chemical binding]; other site 331271006837 putative dimer interface [polypeptide binding]; other site 331271006838 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 331271006839 dimer interface [polypeptide binding]; other site 331271006840 N-terminal domain interface [polypeptide binding]; other site 331271006841 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 331271006842 glycosyl transferase family protein; Provisional; Region: PRK08136 331271006843 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 331271006844 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 331271006845 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 331271006846 active site 331271006847 catalytic residues [active] 331271006848 metal binding site [ion binding]; metal-binding site 331271006849 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 331271006850 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 331271006851 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 331271006852 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331271006853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271006854 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271006855 DNA binding residues [nucleotide binding] 331271006856 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 331271006857 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 331271006858 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 331271006859 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 331271006860 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 331271006861 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 331271006862 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 331271006863 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 331271006864 active site 331271006865 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 331271006866 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 331271006867 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 331271006868 active site turn [active] 331271006869 phosphorylation site [posttranslational modification] 331271006870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 331271006871 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271006872 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271006873 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 331271006874 HPr interaction site; other site 331271006875 glycerol kinase (GK) interaction site [polypeptide binding]; other site 331271006876 active site 331271006877 phosphorylation site [posttranslational modification] 331271006878 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 331271006879 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 331271006880 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 331271006881 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 331271006882 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 331271006883 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331271006884 dimer interface [polypeptide binding]; other site 331271006885 active site 331271006886 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331271006887 dimer interface [polypeptide binding]; other site 331271006888 active site 331271006889 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 331271006890 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 331271006891 active site 331271006892 dimer interface [polypeptide binding]; other site 331271006893 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 331271006894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271006895 DNA-binding site [nucleotide binding]; DNA binding site 331271006896 UTRA domain; Region: UTRA; pfam07702 331271006897 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 331271006898 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 331271006899 putative active site [active] 331271006900 putative PHP Thumb interface [polypeptide binding]; other site 331271006901 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 331271006902 generic binding surface II; other site 331271006903 generic binding surface I; other site 331271006904 DNA Polymerase Y-family; Region: PolY_like; cd03468 331271006905 active site 331271006906 DNA binding site [nucleotide binding] 331271006907 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 331271006908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271006909 Walker A/P-loop; other site 331271006910 ATP binding site [chemical binding]; other site 331271006911 Q-loop/lid; other site 331271006912 ABC transporter signature motif; other site 331271006913 Walker B; other site 331271006914 D-loop; other site 331271006915 H-loop/switch region; other site 331271006916 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271006917 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 331271006918 TM-ABC transporter signature motif; other site 331271006919 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 331271006920 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271006921 zinc binding site [ion binding]; other site 331271006922 putative ligand binding site [chemical binding]; other site 331271006923 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 331271006924 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 331271006925 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 331271006926 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271006927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271006928 dimer interface [polypeptide binding]; other site 331271006929 putative CheW interface [polypeptide binding]; other site 331271006930 YCII-related domain; Region: YCII; cl00999 331271006931 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 331271006932 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 331271006933 Cu(I) binding site [ion binding]; other site 331271006934 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 331271006935 UbiA prenyltransferase family; Region: UbiA; pfam01040 331271006936 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 331271006937 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 331271006938 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 331271006939 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 331271006940 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 331271006941 Subunit III/VIIa interface [polypeptide binding]; other site 331271006942 Phospholipid binding site [chemical binding]; other site 331271006943 Subunit I/III interface [polypeptide binding]; other site 331271006944 Subunit III/VIb interface [polypeptide binding]; other site 331271006945 Subunit III/VIa interface; other site 331271006946 Subunit III/Vb interface [polypeptide binding]; other site 331271006947 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 331271006948 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 331271006949 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 331271006950 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 331271006951 Subunit I/III interface [polypeptide binding]; other site 331271006952 D-pathway; other site 331271006953 Subunit I/VIIc interface [polypeptide binding]; other site 331271006954 Subunit I/IV interface [polypeptide binding]; other site 331271006955 Subunit I/II interface [polypeptide binding]; other site 331271006956 Low-spin heme (heme a) binding site [chemical binding]; other site 331271006957 Subunit I/VIIa interface [polypeptide binding]; other site 331271006958 Subunit I/VIa interface [polypeptide binding]; other site 331271006959 Dimer interface; other site 331271006960 Putative water exit pathway; other site 331271006961 Binuclear center (heme a3/CuB) [ion binding]; other site 331271006962 K-pathway; other site 331271006963 Subunit I/Vb interface [polypeptide binding]; other site 331271006964 Putative proton exit pathway; other site 331271006965 Subunit I/VIb interface; other site 331271006966 Subunit I/VIc interface [polypeptide binding]; other site 331271006967 Electron transfer pathway; other site 331271006968 Subunit I/VIIIb interface [polypeptide binding]; other site 331271006969 Subunit I/VIIb interface [polypeptide binding]; other site 331271006970 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 331271006971 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 331271006972 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 331271006973 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271006974 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 331271006975 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271006976 ligand binding site [chemical binding]; other site 331271006977 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 331271006978 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 331271006979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271006980 S-adenosylmethionine binding site [chemical binding]; other site 331271006981 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 331271006982 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 331271006983 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 331271006984 putative ADP-ribose binding site [chemical binding]; other site 331271006985 putative active site [active] 331271006986 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 331271006987 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 331271006988 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 331271006989 preprotein translocase subunit SecB; Validated; Region: PRK05751 331271006990 SecA binding site; other site 331271006991 Preprotein binding site; other site 331271006992 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 331271006993 GSH binding site [chemical binding]; other site 331271006994 catalytic residues [active] 331271006995 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331271006996 active site residue [active] 331271006997 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331271006998 catalytic core [active] 331271006999 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331271007000 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331271007001 C-terminal peptidase (prc); Region: prc; TIGR00225 331271007002 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331271007003 protein binding site [polypeptide binding]; other site 331271007004 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331271007005 Catalytic dyad [active] 331271007006 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 331271007007 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 331271007008 ATP binding site [chemical binding]; other site 331271007009 substrate interface [chemical binding]; other site 331271007010 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 331271007011 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 331271007012 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 331271007013 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 331271007014 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 331271007015 dimerization domain swap beta strand [polypeptide binding]; other site 331271007016 regulatory protein interface [polypeptide binding]; other site 331271007017 active site 331271007018 regulatory phosphorylation site [posttranslational modification]; other site 331271007019 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 331271007020 active pocket/dimerization site; other site 331271007021 active site 331271007022 phosphorylation site [posttranslational modification] 331271007023 glutathione synthetase; Provisional; Region: PRK05246 331271007024 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 331271007025 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 331271007026 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 331271007027 Glutamate-cysteine ligase; Region: GshA; pfam08886 331271007028 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 331271007029 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 331271007030 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331271007031 Membrane fusogenic activity; Region: BMFP; pfam04380 331271007032 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 331271007033 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 331271007034 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 331271007035 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 331271007036 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 331271007037 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271007038 catalytic residues [active] 331271007039 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331271007040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271007041 active site 331271007042 phosphorylation site [posttranslational modification] 331271007043 intermolecular recognition site; other site 331271007044 dimerization interface [polypeptide binding]; other site 331271007045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271007046 Walker A motif; other site 331271007047 ATP binding site [chemical binding]; other site 331271007048 Walker B motif; other site 331271007049 arginine finger; other site 331271007050 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271007051 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 331271007052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271007053 dimer interface [polypeptide binding]; other site 331271007054 phosphorylation site [posttranslational modification] 331271007055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271007056 ATP binding site [chemical binding]; other site 331271007057 G-X-G motif; other site 331271007058 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 331271007059 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271007060 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 331271007061 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 331271007062 Na binding site [ion binding]; other site 331271007063 Protein of unknown function, DUF485; Region: DUF485; pfam04341 331271007064 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271007065 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271007066 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 331271007067 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 331271007068 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 331271007069 active site 331271007070 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 331271007071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271007072 active site 331271007073 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271007074 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 331271007075 substrate binding site [chemical binding]; other site 331271007076 oxyanion hole (OAH) forming residues; other site 331271007077 trimer interface [polypeptide binding]; other site 331271007078 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271007079 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271007080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271007081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007082 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271007083 putative effector binding pocket; other site 331271007084 dimerization interface [polypeptide binding]; other site 331271007085 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 331271007086 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 331271007087 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 331271007088 trimer interface [polypeptide binding]; other site 331271007089 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 331271007090 Haemagglutinin; Region: HIM; pfam05662 331271007091 YadA-like C-terminal region; Region: YadA; pfam03895 331271007092 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271007093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271007094 dimer interface [polypeptide binding]; other site 331271007095 conserved gate region; other site 331271007096 putative PBP binding loops; other site 331271007097 ABC-ATPase subunit interface; other site 331271007098 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 331271007099 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271007100 Walker A/P-loop; other site 331271007101 ATP binding site [chemical binding]; other site 331271007102 Q-loop/lid; other site 331271007103 ABC transporter signature motif; other site 331271007104 Walker B; other site 331271007105 D-loop; other site 331271007106 H-loop/switch region; other site 331271007107 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 331271007108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271007109 substrate binding pocket [chemical binding]; other site 331271007110 membrane-bound complex binding site; other site 331271007111 hinge residues; other site 331271007112 lipoyl synthase; Provisional; Region: PRK05481 331271007113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271007114 FeS/SAM binding site; other site 331271007115 lipoate-protein ligase B; Provisional; Region: PRK14343 331271007116 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 331271007117 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271007118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007119 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271007120 dimerization interface [polypeptide binding]; other site 331271007121 substrate binding pocket [chemical binding]; other site 331271007122 hypothetical protein; Provisional; Region: PRK02047 331271007123 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 331271007124 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 331271007125 homodimer interface [polypeptide binding]; other site 331271007126 substrate-cofactor binding pocket; other site 331271007127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271007128 catalytic residue [active] 331271007129 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 331271007130 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 331271007131 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 331271007132 Transposase domain (DUF772); Region: DUF772; pfam05598 331271007133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331271007134 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 331271007135 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 331271007136 dimer interface [polypeptide binding]; other site 331271007137 [2Fe-2S] cluster binding site [ion binding]; other site 331271007138 Predicted integral membrane protein [Function unknown]; Region: COG5652 331271007139 Protein of unknown function (DUF330); Region: DUF330; pfam03886 331271007140 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 331271007141 mce related protein; Region: MCE; pfam02470 331271007142 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 331271007143 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 331271007144 Walker A/P-loop; other site 331271007145 ATP binding site [chemical binding]; other site 331271007146 Q-loop/lid; other site 331271007147 ABC transporter signature motif; other site 331271007148 Walker B; other site 331271007149 D-loop; other site 331271007150 H-loop/switch region; other site 331271007151 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 331271007152 Permease; Region: Permease; pfam02405 331271007153 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 331271007154 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 331271007155 active site 331271007156 metal binding site [ion binding]; metal-binding site 331271007157 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 331271007158 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331271007159 Sel1-like repeats; Region: SEL1; smart00671 331271007160 biotin--protein ligase; Provisional; Region: PRK06955 331271007161 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 331271007162 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 331271007163 pantothenate kinase; Reviewed; Region: PRK13328 331271007164 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 331271007165 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 331271007166 active site 331271007167 HIGH motif; other site 331271007168 nucleotide binding site [chemical binding]; other site 331271007169 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 331271007170 dinuclear metal binding motif [ion binding]; other site 331271007171 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 331271007172 active site 331271007173 nucleophile elbow; other site 331271007174 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 331271007175 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271007176 substrate binding site [chemical binding]; other site 331271007177 oxyanion hole (OAH) forming residues; other site 331271007178 trimer interface [polypeptide binding]; other site 331271007179 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331271007180 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271007181 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271007182 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271007183 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 331271007184 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 331271007185 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 331271007186 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 331271007187 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 331271007188 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 331271007189 substrate binding pocket [chemical binding]; other site 331271007190 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 331271007191 B12 binding site [chemical binding]; other site 331271007192 cobalt ligand [ion binding]; other site 331271007193 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 331271007194 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 331271007195 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 331271007196 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 331271007197 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 331271007198 active site 331271007199 HIGH motif; other site 331271007200 KMSK motif region; other site 331271007201 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 331271007202 tRNA binding surface [nucleotide binding]; other site 331271007203 anticodon binding site; other site 331271007204 Sporulation related domain; Region: SPOR; pfam05036 331271007205 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 331271007206 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 331271007207 catalytic residues [active] 331271007208 hinge region; other site 331271007209 alpha helical domain; other site 331271007210 short chain dehydrogenase; Provisional; Region: PRK07024 331271007211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271007212 NAD(P) binding site [chemical binding]; other site 331271007213 active site 331271007214 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331271007215 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 331271007216 peptide binding site [polypeptide binding]; other site 331271007217 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 331271007218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271007219 Walker A/P-loop; other site 331271007220 ATP binding site [chemical binding]; other site 331271007221 Q-loop/lid; other site 331271007222 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271007223 ABC transporter signature motif; other site 331271007224 Walker B; other site 331271007225 D-loop; other site 331271007226 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271007227 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 331271007228 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 331271007229 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 331271007230 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 331271007231 active site clefts [active] 331271007232 zinc binding site [ion binding]; other site 331271007233 dimer interface [polypeptide binding]; other site 331271007234 C factor cell-cell signaling protein; Provisional; Region: PRK09009 331271007235 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 331271007236 NADP binding site [chemical binding]; other site 331271007237 homodimer interface [polypeptide binding]; other site 331271007238 active site 331271007239 hypothetical protein; Provisional; Region: PRK01842 331271007240 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 331271007241 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271007242 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 331271007243 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271007244 inhibitor-cofactor binding pocket; inhibition site 331271007245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271007246 catalytic residue [active] 331271007247 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 331271007248 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 331271007249 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271007250 catalytic residue [active] 331271007251 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 331271007252 AAA domain; Region: AAA_26; pfam13500 331271007253 biotin synthase; Provisional; Region: PRK15108 331271007254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271007255 FeS/SAM binding site; other site 331271007256 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 331271007257 CutC family; Region: CutC; cl01218 331271007258 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271007259 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 331271007260 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331271007261 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 331271007262 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331271007263 dimer interface [polypeptide binding]; other site 331271007264 PYR/PP interface [polypeptide binding]; other site 331271007265 TPP binding site [chemical binding]; other site 331271007266 substrate binding site [chemical binding]; other site 331271007267 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 331271007268 TPP-binding site; other site 331271007269 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 331271007270 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 331271007271 active site 331271007272 substrate binding site [chemical binding]; other site 331271007273 trimer interface [polypeptide binding]; other site 331271007274 CoA binding site [chemical binding]; other site 331271007275 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271007276 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 331271007277 putative C-terminal domain interface [polypeptide binding]; other site 331271007278 putative GSH binding site (G-site) [chemical binding]; other site 331271007279 putative dimer interface [polypeptide binding]; other site 331271007280 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 331271007281 dimer interface [polypeptide binding]; other site 331271007282 N-terminal domain interface [polypeptide binding]; other site 331271007283 putative substrate binding pocket (H-site) [chemical binding]; other site 331271007284 Inward rectifier potassium channel; Region: IRK; pfam01007 331271007285 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 331271007286 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 331271007287 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271007288 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 331271007289 dimer interface [polypeptide binding]; other site 331271007290 active site 331271007291 catalytic residue [active] 331271007292 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 331271007293 putative active site [active] 331271007294 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 331271007295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271007297 dimerization interface [polypeptide binding]; other site 331271007298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271007299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271007300 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 331271007301 C-terminal domain interface [polypeptide binding]; other site 331271007302 GSH binding site (G-site) [chemical binding]; other site 331271007303 dimer interface [polypeptide binding]; other site 331271007304 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 331271007305 dimer interface [polypeptide binding]; other site 331271007306 substrate binding pocket (H-site) [chemical binding]; other site 331271007307 N-terminal domain interface [polypeptide binding]; other site 331271007308 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271007309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007310 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271007311 dimerization interface [polypeptide binding]; other site 331271007312 substrate binding pocket [chemical binding]; other site 331271007313 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271007314 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271007315 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271007316 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 331271007317 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 331271007318 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 331271007319 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271007320 catalytic loop [active] 331271007321 iron binding site [ion binding]; other site 331271007322 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271007323 Serine hydrolase; Region: Ser_hydrolase; pfam06821 331271007324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271007325 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 331271007326 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 331271007327 putative ligand binding site [chemical binding]; other site 331271007328 NAD binding site [chemical binding]; other site 331271007329 dimerization interface [polypeptide binding]; other site 331271007330 catalytic site [active] 331271007331 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 331271007332 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 331271007333 active site 331271007334 catalytic residues [active] 331271007335 metal binding site [ion binding]; metal-binding site 331271007336 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 331271007337 putative deacylase active site [active] 331271007338 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 331271007339 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 331271007340 EamA-like transporter family; Region: EamA; pfam00892 331271007341 EamA-like transporter family; Region: EamA; pfam00892 331271007342 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271007343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271007344 dimerization interface [polypeptide binding]; other site 331271007345 putative DNA binding site [nucleotide binding]; other site 331271007346 putative Zn2+ binding site [ion binding]; other site 331271007347 AsnC family; Region: AsnC_trans_reg; pfam01037 331271007348 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 331271007349 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 331271007350 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 331271007351 FMN binding site [chemical binding]; other site 331271007352 substrate binding site [chemical binding]; other site 331271007353 putative catalytic residue [active] 331271007354 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271007355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007356 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271007357 putative effector binding pocket; other site 331271007358 dimerization interface [polypeptide binding]; other site 331271007359 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271007360 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271007361 eyelet of channel; other site 331271007362 trimer interface [polypeptide binding]; other site 331271007363 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 331271007364 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 331271007365 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271007366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 331271007367 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271007368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271007369 metal binding site [ion binding]; metal-binding site 331271007370 active site 331271007371 I-site; other site 331271007372 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271007373 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271007374 DNA binding site [nucleotide binding] 331271007375 domain linker motif; other site 331271007376 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 331271007377 ligand binding site [chemical binding]; other site 331271007378 dimerization interface [polypeptide binding]; other site 331271007379 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 331271007380 dimerization interface [polypeptide binding]; other site 331271007381 putative active cleft [active] 331271007382 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 331271007383 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271007384 putative substrate binding site [chemical binding]; other site 331271007385 putative ATP binding site [chemical binding]; other site 331271007386 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 331271007387 Uncharacterized conserved protein [Function unknown]; Region: COG1565 331271007388 short chain dehydrogenase; Provisional; Region: PRK09134 331271007389 Dihydroneopterin aldolase; Region: FolB; smart00905 331271007390 active site 331271007391 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 331271007392 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 331271007393 Ligand Binding Site [chemical binding]; other site 331271007394 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 331271007395 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 331271007396 Substrate binding site; other site 331271007397 Mg++ binding site; other site 331271007398 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 331271007399 active site 331271007400 substrate binding site [chemical binding]; other site 331271007401 CoA binding site [chemical binding]; other site 331271007402 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331271007403 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331271007404 glutaminase active site [active] 331271007405 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331271007406 dimer interface [polypeptide binding]; other site 331271007407 active site 331271007408 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331271007409 dimer interface [polypeptide binding]; other site 331271007410 active site 331271007411 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 331271007412 Predicted transcriptional regulator [Transcription]; Region: COG2944 331271007413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271007414 non-specific DNA binding site [nucleotide binding]; other site 331271007415 salt bridge; other site 331271007416 sequence-specific DNA binding site [nucleotide binding]; other site 331271007417 Iron permease FTR1 family; Region: FTR1; cl00475 331271007418 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 331271007419 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 331271007420 metal-binding site [ion binding] 331271007421 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 331271007422 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 331271007423 NAD(P) binding site [chemical binding]; other site 331271007424 catalytic residues [active] 331271007425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271007426 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 331271007427 non-specific DNA binding site [nucleotide binding]; other site 331271007428 salt bridge; other site 331271007429 sequence-specific DNA binding site [nucleotide binding]; other site 331271007430 Cupin domain; Region: Cupin_2; pfam07883 331271007431 Peptidase C26; Region: Peptidase_C26; pfam07722 331271007432 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 331271007433 catalytic triad [active] 331271007434 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 331271007435 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 331271007436 putative aminotransferase; Validated; Region: PRK07480 331271007437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271007438 inhibitor-cofactor binding pocket; inhibition site 331271007439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271007440 catalytic residue [active] 331271007441 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 331271007442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 331271007443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271007444 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 331271007445 Walker A/P-loop; other site 331271007446 ATP binding site [chemical binding]; other site 331271007447 Q-loop/lid; other site 331271007448 ABC transporter signature motif; other site 331271007449 Walker B; other site 331271007450 D-loop; other site 331271007451 H-loop/switch region; other site 331271007452 TOBE domain; Region: TOBE_2; pfam08402 331271007453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271007454 dimer interface [polypeptide binding]; other site 331271007455 conserved gate region; other site 331271007456 putative PBP binding loops; other site 331271007457 ABC-ATPase subunit interface; other site 331271007458 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271007459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271007460 dimer interface [polypeptide binding]; other site 331271007461 conserved gate region; other site 331271007462 putative PBP binding loops; other site 331271007463 ABC-ATPase subunit interface; other site 331271007464 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 331271007465 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 331271007466 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271007467 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271007468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 331271007469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 331271007470 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 331271007471 glutathione reductase; Validated; Region: PRK06116 331271007472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271007473 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331271007474 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271007475 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271007476 eyelet of channel; other site 331271007477 trimer interface [polypeptide binding]; other site 331271007478 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 331271007479 Chromate transporter; Region: Chromate_transp; pfam02417 331271007480 Chromate transporter; Region: Chromate_transp; pfam02417 331271007481 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271007482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007483 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271007484 dimerization interface [polypeptide binding]; other site 331271007485 substrate binding pocket [chemical binding]; other site 331271007486 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 331271007487 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 331271007488 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 331271007489 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 331271007490 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 331271007491 Flagellar regulator YcgR; Region: YcgR; pfam07317 331271007492 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 331271007493 PilZ domain; Region: PilZ; pfam07238 331271007494 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 331271007495 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 331271007496 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 331271007497 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 331271007498 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 331271007499 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 331271007500 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 331271007501 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 331271007502 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 331271007503 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 331271007504 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 331271007505 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 331271007506 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 331271007507 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 331271007508 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 331271007509 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 331271007510 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 331271007511 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 331271007512 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 331271007513 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 331271007514 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 331271007515 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 331271007516 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 331271007517 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 331271007518 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 331271007519 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 331271007520 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 331271007521 FlgN protein; Region: FlgN; pfam05130 331271007522 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 331271007523 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 331271007524 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 331271007525 active site 331271007526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271007527 sequence-specific DNA binding site [nucleotide binding]; other site 331271007528 salt bridge; other site 331271007529 Cupin domain; Region: Cupin_2; pfam07883 331271007530 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 331271007531 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 331271007532 active site 331271007533 NTP binding site [chemical binding]; other site 331271007534 metal binding triad [ion binding]; metal-binding site 331271007535 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 331271007536 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 331271007537 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271007538 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 331271007539 putative C-terminal domain interface [polypeptide binding]; other site 331271007540 putative GSH binding site (G-site) [chemical binding]; other site 331271007541 putative dimer interface [polypeptide binding]; other site 331271007542 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 331271007543 putative N-terminal domain interface [polypeptide binding]; other site 331271007544 putative dimer interface [polypeptide binding]; other site 331271007545 putative substrate binding pocket (H-site) [chemical binding]; other site 331271007546 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 331271007547 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 331271007548 putative NAD(P) binding site [chemical binding]; other site 331271007549 active site 331271007550 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 331271007551 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271007552 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271007553 catalytic residue [active] 331271007554 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 331271007555 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 331271007556 MarR family; Region: MarR_2; cl17246 331271007557 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271007558 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 331271007559 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 331271007560 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 331271007561 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 331271007562 putative active site [active] 331271007563 TraB family; Region: TraB; pfam01963 331271007564 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 331271007565 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271007566 Walker A/P-loop; other site 331271007567 ATP binding site [chemical binding]; other site 331271007568 Q-loop/lid; other site 331271007569 ABC transporter signature motif; other site 331271007570 Walker B; other site 331271007571 D-loop; other site 331271007572 H-loop/switch region; other site 331271007573 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 331271007574 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 331271007575 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271007576 Walker A/P-loop; other site 331271007577 ATP binding site [chemical binding]; other site 331271007578 Q-loop/lid; other site 331271007579 ABC transporter signature motif; other site 331271007580 Walker B; other site 331271007581 D-loop; other site 331271007582 H-loop/switch region; other site 331271007583 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271007584 dipeptide transporter; Provisional; Region: PRK10913 331271007585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271007586 dimer interface [polypeptide binding]; other site 331271007587 conserved gate region; other site 331271007588 putative PBP binding loops; other site 331271007589 ABC-ATPase subunit interface; other site 331271007590 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331271007591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271007592 dimer interface [polypeptide binding]; other site 331271007593 conserved gate region; other site 331271007594 putative PBP binding loops; other site 331271007595 ABC-ATPase subunit interface; other site 331271007596 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331271007597 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 331271007598 peptide binding site [polypeptide binding]; other site 331271007599 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271007600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271007601 putative substrate translocation pore; other site 331271007602 High potential iron-sulfur protein; Region: HIPIP; pfam01355 331271007603 Predicted dehydrogenase [General function prediction only]; Region: COG0579 331271007604 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271007605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271007606 ATP binding site [chemical binding]; other site 331271007607 Walker B motif; other site 331271007608 arginine finger; other site 331271007609 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 331271007610 putative FMN binding site [chemical binding]; other site 331271007611 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331271007612 putative catalytic site [active] 331271007613 putative phosphate binding site [ion binding]; other site 331271007614 putative metal binding site [ion binding]; other site 331271007615 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 331271007616 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 331271007617 FAD binding pocket [chemical binding]; other site 331271007618 FAD binding motif [chemical binding]; other site 331271007619 phosphate binding motif [ion binding]; other site 331271007620 beta-alpha-beta structure motif; other site 331271007621 NAD binding pocket [chemical binding]; other site 331271007622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271007623 ATP binding site [chemical binding]; other site 331271007624 Mg2+ binding site [ion binding]; other site 331271007625 G-X-G motif; other site 331271007626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271007627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271007628 active site 331271007629 phosphorylation site [posttranslational modification] 331271007630 intermolecular recognition site; other site 331271007631 dimerization interface [polypeptide binding]; other site 331271007632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271007633 DNA binding residues [nucleotide binding] 331271007634 dimerization interface [polypeptide binding]; other site 331271007635 amino acid transporter; Region: 2A0306; TIGR00909 331271007636 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 331271007637 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 331271007638 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 331271007639 XdhC Rossmann domain; Region: XdhC_C; pfam13478 331271007640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 331271007641 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 331271007642 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 331271007643 Flagellar protein FliS; Region: FliS; cl00654 331271007644 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 331271007645 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 331271007646 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 331271007647 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 331271007648 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 331271007649 FliG C-terminal domain; Region: FliG_C; pfam01706 331271007650 flagellar assembly protein H; Validated; Region: fliH; PRK05687 331271007651 Flagellar assembly protein FliH; Region: FliH; pfam02108 331271007652 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 331271007653 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 331271007654 Walker A motif/ATP binding site; other site 331271007655 Walker B motif; other site 331271007656 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 331271007657 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 331271007658 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 331271007659 choline dehydrogenase; Validated; Region: PRK02106 331271007660 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271007661 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 331271007662 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 331271007663 NAD(P) binding site [chemical binding]; other site 331271007664 catalytic residues [active] 331271007665 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 331271007666 serine/threonine protein kinase; Provisional; Region: PRK11768 331271007667 EamA-like transporter family; Region: EamA; pfam00892 331271007668 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271007669 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271007670 active site 331271007671 catalytic tetrad [active] 331271007672 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 331271007673 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 331271007674 S-adenosylmethionine synthetase; Validated; Region: PRK05250 331271007675 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 331271007676 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 331271007677 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 331271007678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 331271007679 putative acyl-acceptor binding pocket; other site 331271007680 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 331271007681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271007682 sequence-specific DNA binding site [nucleotide binding]; other site 331271007683 salt bridge; other site 331271007684 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 331271007685 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 331271007686 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331271007687 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331271007688 Protein of unknown function, DUF484; Region: DUF484; cl17449 331271007689 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 331271007690 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331271007691 active site 331271007692 DNA binding site [nucleotide binding] 331271007693 Int/Topo IB signature motif; other site 331271007694 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 331271007695 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 331271007696 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 331271007697 putative RNA binding site [nucleotide binding]; other site 331271007698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271007699 S-adenosylmethionine binding site [chemical binding]; other site 331271007700 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 331271007701 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 331271007702 P-loop, Walker A motif; other site 331271007703 Base recognition motif; other site 331271007704 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 331271007705 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 331271007706 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 331271007707 active site 331271007708 HslU subunit interaction site [polypeptide binding]; other site 331271007709 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 331271007710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271007711 Walker A motif; other site 331271007712 ATP binding site [chemical binding]; other site 331271007713 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 331271007714 Walker B motif; other site 331271007715 arginine finger; other site 331271007716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 331271007717 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 331271007718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271007719 active site 331271007720 phosphorylation site [posttranslational modification] 331271007721 intermolecular recognition site; other site 331271007722 dimerization interface [polypeptide binding]; other site 331271007723 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271007724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271007725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271007726 dimer interface [polypeptide binding]; other site 331271007727 phosphorylation site [posttranslational modification] 331271007728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271007729 ATP binding site [chemical binding]; other site 331271007730 Mg2+ binding site [ion binding]; other site 331271007731 G-X-G motif; other site 331271007732 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 331271007733 feedback inhibition sensing region; other site 331271007734 homohexameric interface [polypeptide binding]; other site 331271007735 nucleotide binding site [chemical binding]; other site 331271007736 N-acetyl-L-glutamate binding site [chemical binding]; other site 331271007737 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 331271007738 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 331271007739 division inhibitor protein; Provisional; Region: slmA; PRK09480 331271007740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271007741 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 331271007742 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 331271007743 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331271007744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271007745 S-adenosylmethionine binding site [chemical binding]; other site 331271007746 muropeptide transporter; Reviewed; Region: ampG; PRK11902 331271007747 AmpG-like permease; Region: 2A0125; TIGR00901 331271007748 Peptidase family M48; Region: Peptidase_M48; cl12018 331271007749 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 331271007750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271007751 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 331271007752 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 331271007753 putative NAD(P) binding site [chemical binding]; other site 331271007754 putative substrate binding site [chemical binding]; other site 331271007755 catalytic Zn binding site [ion binding]; other site 331271007756 structural Zn binding site [ion binding]; other site 331271007757 dimer interface [polypeptide binding]; other site 331271007758 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 331271007759 putative active site [active] 331271007760 putative catalytic site [active] 331271007761 putative DNA binding site [nucleotide binding]; other site 331271007762 putative phosphate binding site [ion binding]; other site 331271007763 metal binding site A [ion binding]; metal-binding site 331271007764 putative AP binding site [nucleotide binding]; other site 331271007765 putative metal binding site B [ion binding]; other site 331271007766 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 331271007767 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 331271007768 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 331271007769 GatB domain; Region: GatB_Yqey; smart00845 331271007770 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 331271007771 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 331271007772 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 331271007773 rod shape-determining protein MreB; Provisional; Region: PRK13927 331271007774 MreB and similar proteins; Region: MreB_like; cd10225 331271007775 nucleotide binding site [chemical binding]; other site 331271007776 Mg binding site [ion binding]; other site 331271007777 putative protofilament interaction site [polypeptide binding]; other site 331271007778 RodZ interaction site [polypeptide binding]; other site 331271007779 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 331271007780 rod shape-determining protein MreC; Region: MreC; pfam04085 331271007781 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 331271007782 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 331271007783 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331271007784 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331271007785 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 331271007786 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331271007787 Sel1-like repeats; Region: SEL1; smart00671 331271007788 Sel1-like repeats; Region: SEL1; smart00671 331271007789 Sel1-like repeats; Region: SEL1; smart00671 331271007790 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 331271007791 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 331271007792 active site 331271007793 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 331271007794 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 331271007795 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 331271007796 Ligand Binding Site [chemical binding]; other site 331271007797 Response regulator receiver domain; Region: Response_reg; pfam00072 331271007798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271007799 active site 331271007800 phosphorylation site [posttranslational modification] 331271007801 intermolecular recognition site; other site 331271007802 dimerization interface [polypeptide binding]; other site 331271007803 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 331271007804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271007805 dimerization interface [polypeptide binding]; other site 331271007806 PAS domain; Region: PAS; smart00091 331271007807 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 331271007808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271007809 dimer interface [polypeptide binding]; other site 331271007810 phosphorylation site [posttranslational modification] 331271007811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271007812 ATP binding site [chemical binding]; other site 331271007813 Mg2+ binding site [ion binding]; other site 331271007814 G-X-G motif; other site 331271007815 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 331271007816 16S rRNA methyltransferase B; Provisional; Region: PRK10901 331271007817 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 331271007818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271007819 S-adenosylmethionine binding site [chemical binding]; other site 331271007820 M48 family peptidase; Provisional; Region: PRK03001 331271007821 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271007822 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 331271007823 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 331271007824 putative active site [active] 331271007825 substrate binding site [chemical binding]; other site 331271007826 putative cosubstrate binding site; other site 331271007827 catalytic site [active] 331271007828 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 331271007829 substrate binding site [chemical binding]; other site 331271007830 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 331271007831 active site 331271007832 catalytic residues [active] 331271007833 metal binding site [ion binding]; metal-binding site 331271007834 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 331271007835 DNA protecting protein DprA; Region: dprA; TIGR00732 331271007836 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331271007837 catalytic residues [active] 331271007838 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271007839 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271007840 DNA topoisomerase III; Validated; Region: PRK08173 331271007841 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 331271007842 active site 331271007843 putative interdomain interaction site [polypeptide binding]; other site 331271007844 putative metal-binding site [ion binding]; other site 331271007845 putative nucleotide binding site [chemical binding]; other site 331271007846 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 331271007847 domain I; other site 331271007848 DNA binding groove [nucleotide binding] 331271007849 phosphate binding site [ion binding]; other site 331271007850 domain II; other site 331271007851 domain III; other site 331271007852 nucleotide binding site [chemical binding]; other site 331271007853 catalytic site [active] 331271007854 domain IV; other site 331271007855 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 331271007856 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 331271007857 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271007858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007859 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271007860 putative effector binding pocket; other site 331271007861 dimerization interface [polypeptide binding]; other site 331271007862 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 331271007863 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 331271007864 dimerization interface [polypeptide binding]; other site 331271007865 NAD binding site [chemical binding]; other site 331271007866 ligand binding site [chemical binding]; other site 331271007867 catalytic site [active] 331271007868 Patatin-like phospholipase; Region: Patatin; pfam01734 331271007869 active site 331271007870 nucleophile elbow; other site 331271007871 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 331271007872 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 331271007873 CoenzymeA binding site [chemical binding]; other site 331271007874 subunit interaction site [polypeptide binding]; other site 331271007875 PHB binding site; other site 331271007876 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 331271007877 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 331271007878 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 331271007879 CGNR zinc finger; Region: zf-CGNR; pfam11706 331271007880 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271007881 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 331271007882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271007883 Walker A/P-loop; other site 331271007884 ATP binding site [chemical binding]; other site 331271007885 Q-loop/lid; other site 331271007886 ABC transporter signature motif; other site 331271007887 Walker B; other site 331271007888 D-loop; other site 331271007889 H-loop/switch region; other site 331271007890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271007891 dimer interface [polypeptide binding]; other site 331271007892 conserved gate region; other site 331271007893 putative PBP binding loops; other site 331271007894 ABC-ATPase subunit interface; other site 331271007895 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271007896 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271007897 substrate binding pocket [chemical binding]; other site 331271007898 membrane-bound complex binding site; other site 331271007899 hinge residues; other site 331271007900 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 331271007901 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 331271007902 NAD(P) binding site [chemical binding]; other site 331271007903 catalytic residues [active] 331271007904 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 331271007905 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 331271007906 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271007907 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271007908 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 331271007909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271007910 DNA-binding site [nucleotide binding]; DNA binding site 331271007911 FCD domain; Region: FCD; pfam07729 331271007912 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 331271007913 Phosphoesterase family; Region: Phosphoesterase; pfam04185 331271007914 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271007915 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271007916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271007917 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 331271007918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271007919 dimerization interface [polypeptide binding]; other site 331271007920 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 331271007921 L-lactate permease; Region: Lactate_perm; cl00701 331271007922 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271007923 glutamate--cysteine ligase; Provisional; Region: PRK02107 331271007924 AlkA N-terminal domain; Region: AlkA_N; pfam06029 331271007925 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 331271007926 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331271007927 minor groove reading motif; other site 331271007928 helix-hairpin-helix signature motif; other site 331271007929 substrate binding pocket [chemical binding]; other site 331271007930 active site 331271007931 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 331271007932 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 331271007933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271007934 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 331271007935 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 331271007936 DNA binding site [nucleotide binding] 331271007937 active site 331271007938 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 331271007939 dimer interface [polypeptide binding]; other site 331271007940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271007941 metal binding site [ion binding]; metal-binding site 331271007942 YaeQ protein; Region: YaeQ; pfam07152 331271007943 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 331271007944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271007945 Coenzyme A binding pocket [chemical binding]; other site 331271007946 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 331271007947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271007948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271007949 metal binding site [ion binding]; metal-binding site 331271007950 active site 331271007951 I-site; other site 331271007952 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 331271007953 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 331271007954 trmE is a tRNA modification GTPase; Region: trmE; cd04164 331271007955 G1 box; other site 331271007956 GTP/Mg2+ binding site [chemical binding]; other site 331271007957 Switch I region; other site 331271007958 G2 box; other site 331271007959 Switch II region; other site 331271007960 G3 box; other site 331271007961 G4 box; other site 331271007962 G5 box; other site 331271007963 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 331271007964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271007965 non-specific DNA binding site [nucleotide binding]; other site 331271007966 salt bridge; other site 331271007967 sequence-specific DNA binding site [nucleotide binding]; other site 331271007968 membrane protein insertase; Provisional; Region: PRK01318 331271007969 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 331271007970 hypothetical protein; Validated; Region: PRK00041 331271007971 Ribonuclease P; Region: Ribonuclease_P; cl00457 331271007972 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 331271007973 DnaA N-terminal domain; Region: DnaA_N; pfam11638 331271007974 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 331271007975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271007976 Walker A motif; other site 331271007977 ATP binding site [chemical binding]; other site 331271007978 Walker B motif; other site 331271007979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 331271007980 arginine finger; other site 331271007981 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 331271007982 DnaA box-binding interface [nucleotide binding]; other site 331271007983 DNA polymerase III subunit beta; Validated; Region: PRK05643 331271007984 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 331271007985 putative DNA binding surface [nucleotide binding]; other site 331271007986 dimer interface [polypeptide binding]; other site 331271007987 beta-clamp/clamp loader binding surface; other site 331271007988 beta-clamp/translesion DNA polymerase binding surface; other site 331271007989 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 331271007990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271007991 ATP binding site [chemical binding]; other site 331271007992 Mg2+ binding site [ion binding]; other site 331271007993 G-X-G motif; other site 331271007994 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 331271007995 anchoring element; other site 331271007996 dimer interface [polypeptide binding]; other site 331271007997 ATP binding site [chemical binding]; other site 331271007998 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 331271007999 active site 331271008000 putative metal-binding site [ion binding]; other site 331271008001 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 331271008002 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 331271008003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331271008004 Integrase core domain; Region: rve; pfam00665 331271008005 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331271008006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271008007 Walker A motif; other site 331271008008 ATP binding site [chemical binding]; other site 331271008009 Walker B motif; other site 331271008010 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 331271008011 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 331271008012 DNA-binding interface [nucleotide binding]; DNA binding site 331271008013 HTH-like domain; Region: HTH_21; pfam13276 331271008014 enoyl-CoA hydratase; Provisional; Region: PRK05862 331271008015 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271008016 substrate binding site [chemical binding]; other site 331271008017 oxyanion hole (OAH) forming residues; other site 331271008018 trimer interface [polypeptide binding]; other site 331271008019 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 331271008020 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 331271008021 NAD(P) binding site [chemical binding]; other site 331271008022 catalytic residues [active] 331271008023 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 331271008024 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271008025 dimer interface [polypeptide binding]; other site 331271008026 active site 331271008027 enoyl-CoA hydratase; Provisional; Region: PRK08140 331271008028 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271008029 substrate binding site [chemical binding]; other site 331271008030 oxyanion hole (OAH) forming residues; other site 331271008031 trimer interface [polypeptide binding]; other site 331271008032 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 331271008033 CoenzymeA binding site [chemical binding]; other site 331271008034 subunit interaction site [polypeptide binding]; other site 331271008035 PHB binding site; other site 331271008036 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 331271008037 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 331271008038 active site 331271008039 AMP binding site [chemical binding]; other site 331271008040 homodimer interface [polypeptide binding]; other site 331271008041 acyl-activating enzyme (AAE) consensus motif; other site 331271008042 CoA binding site [chemical binding]; other site 331271008043 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 331271008044 MltA specific insert domain; Region: MltA; smart00925 331271008045 3D domain; Region: 3D; pfam06725 331271008046 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 331271008047 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 331271008048 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 331271008049 substrate binding site [chemical binding]; other site 331271008050 hexamer interface [polypeptide binding]; other site 331271008051 metal binding site [ion binding]; metal-binding site 331271008052 phosphoglycolate phosphatase; Provisional; Region: PRK13222 331271008053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 331271008054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271008055 motif II; other site 331271008056 anthranilate synthase component I; Provisional; Region: PRK13565 331271008057 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 331271008058 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 331271008059 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 331271008060 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 331271008061 glutamine binding [chemical binding]; other site 331271008062 catalytic triad [active] 331271008063 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 331271008064 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 331271008065 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 331271008066 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 331271008067 active site 331271008068 ribulose/triose binding site [chemical binding]; other site 331271008069 phosphate binding site [ion binding]; other site 331271008070 substrate (anthranilate) binding pocket [chemical binding]; other site 331271008071 product (indole) binding pocket [chemical binding]; other site 331271008072 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 331271008073 putative active site [active] 331271008074 putative metal binding residues [ion binding]; other site 331271008075 signature motif; other site 331271008076 putative triphosphate binding site [ion binding]; other site 331271008077 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 331271008078 ligand binding site [chemical binding]; other site 331271008079 active site 331271008080 UGI interface [polypeptide binding]; other site 331271008081 catalytic site [active] 331271008082 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 331271008083 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271008084 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 331271008085 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 331271008086 PDZ domain; Region: PDZ_2; pfam13180 331271008087 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 331271008088 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 331271008089 dimerization domain [polypeptide binding]; other site 331271008090 dimer interface [polypeptide binding]; other site 331271008091 catalytic residues [active] 331271008092 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 331271008093 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 331271008094 GTP-binding protein YchF; Reviewed; Region: PRK09601 331271008095 YchF GTPase; Region: YchF; cd01900 331271008096 G1 box; other site 331271008097 GTP/Mg2+ binding site [chemical binding]; other site 331271008098 Switch I region; other site 331271008099 G2 box; other site 331271008100 Switch II region; other site 331271008101 G3 box; other site 331271008102 G4 box; other site 331271008103 G5 box; other site 331271008104 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 331271008105 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 331271008106 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 331271008107 Protein of unknown function (DUF419); Region: DUF419; cl15265 331271008108 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 331271008109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271008110 putative substrate translocation pore; other site 331271008111 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271008112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271008113 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271008114 dimerization interface [polypeptide binding]; other site 331271008115 substrate binding pocket [chemical binding]; other site 331271008116 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 331271008117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271008118 Walker A/P-loop; other site 331271008119 ATP binding site [chemical binding]; other site 331271008120 Q-loop/lid; other site 331271008121 ABC transporter signature motif; other site 331271008122 Walker B; other site 331271008123 D-loop; other site 331271008124 H-loop/switch region; other site 331271008125 ABC transporter; Region: ABC_tran_2; pfam12848 331271008126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271008127 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 331271008128 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 331271008129 Isochorismatase family; Region: Isochorismatase; pfam00857 331271008130 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 331271008131 catalytic triad [active] 331271008132 conserved cis-peptide bond; other site 331271008133 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 331271008134 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 331271008135 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 331271008136 active site 331271008137 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271008138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271008139 active site 331271008140 phosphorylation site [posttranslational modification] 331271008141 intermolecular recognition site; other site 331271008142 dimerization interface [polypeptide binding]; other site 331271008143 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271008144 DNA binding site [nucleotide binding] 331271008145 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 331271008146 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 331271008147 tRNA; other site 331271008148 putative tRNA binding site [nucleotide binding]; other site 331271008149 putative NADP binding site [chemical binding]; other site 331271008150 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 331271008151 Transposase domain (DUF772); Region: DUF772; pfam05598 331271008152 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331271008153 peptide chain release factor 1; Validated; Region: prfA; PRK00591 331271008154 This domain is found in peptide chain release factors; Region: PCRF; smart00937 331271008155 RF-1 domain; Region: RF-1; pfam00472 331271008156 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 331271008157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271008158 S-adenosylmethionine binding site [chemical binding]; other site 331271008159 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 331271008160 putative GSH binding site [chemical binding]; other site 331271008161 catalytic residues [active] 331271008162 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 331271008163 Flavoprotein; Region: Flavoprotein; pfam02441 331271008164 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 331271008165 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 331271008166 putative active site [active] 331271008167 metal binding site [ion binding]; metal-binding site 331271008168 amino acid transporter; Region: 2A0306; TIGR00909 331271008169 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 331271008170 DNA-binding site [nucleotide binding]; DNA binding site 331271008171 RNA-binding motif; other site 331271008172 putative chaperone; Provisional; Region: PRK11678 331271008173 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 331271008174 nucleotide binding site [chemical binding]; other site 331271008175 putative NEF/HSP70 interaction site [polypeptide binding]; other site 331271008176 SBD interface [polypeptide binding]; other site 331271008177 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 331271008178 putative FMN binding site [chemical binding]; other site 331271008179 D-galactonate transporter; Region: 2A0114; TIGR00893 331271008180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271008181 putative substrate translocation pore; other site 331271008182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271008183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271008184 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 331271008185 Methyltransferase domain; Region: Methyltransf_32; pfam13679 331271008186 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 331271008187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271008188 S-adenosylmethionine binding site [chemical binding]; other site 331271008189 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 331271008190 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 331271008191 Water Stress and Hypersensitive response; Region: WHy; smart00769 331271008192 Peptidase family M1; Region: Peptidase_M1; pfam01433 331271008193 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 331271008194 Zn binding site [ion binding]; other site 331271008195 transcriptional activator TtdR; Provisional; Region: PRK09801 331271008196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271008197 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271008198 putative effector binding pocket; other site 331271008199 dimerization interface [polypeptide binding]; other site 331271008200 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 331271008201 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271008202 NAD(P) binding site [chemical binding]; other site 331271008203 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 331271008204 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 331271008205 Cl binding site [ion binding]; other site 331271008206 oligomer interface [polypeptide binding]; other site 331271008207 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 331271008208 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 331271008209 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 331271008210 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 331271008211 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 331271008212 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 331271008213 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 331271008214 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331271008215 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271008216 ligand binding site [chemical binding]; other site 331271008217 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 331271008218 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331271008219 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271008220 ligand binding site [chemical binding]; other site 331271008221 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 331271008222 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 331271008223 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 331271008224 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 331271008225 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 331271008226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 331271008227 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 331271008228 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 331271008229 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 331271008230 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 331271008231 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 331271008232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271008233 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331271008234 Walker A motif; other site 331271008235 ATP binding site [chemical binding]; other site 331271008236 Walker B motif; other site 331271008237 arginine finger; other site 331271008238 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 331271008239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271008240 Walker A motif; other site 331271008241 ATP binding site [chemical binding]; other site 331271008242 Walker B motif; other site 331271008243 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 331271008244 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 331271008245 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 331271008246 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 331271008247 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 331271008248 Protein of unknown function (DUF796); Region: DUF796; pfam05638 331271008249 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 331271008250 Protein of unknown function (DUF877); Region: DUF877; pfam05943 331271008251 Protein of unknown function (DUF770); Region: DUF770; pfam05591 331271008252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271008253 TPR motif; other site 331271008254 binding surface 331271008255 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 331271008256 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 331271008257 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 331271008258 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 331271008259 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 331271008260 RHS protein; Region: RHS; pfam03527 331271008261 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 331271008262 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 331271008263 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 331271008264 RHS Repeat; Region: RHS_repeat; pfam05593 331271008265 RHS Repeat; Region: RHS_repeat; pfam05593 331271008266 RHS Repeat; Region: RHS_repeat; pfam05593 331271008267 RHS Repeat; Region: RHS_repeat; pfam05593 331271008268 RHS Repeat; Region: RHS_repeat; pfam05593 331271008269 RHS Repeat; Region: RHS_repeat; pfam05593 331271008270 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 331271008271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 331271008272 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 331271008273 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 331271008274 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 331271008275 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 331271008276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271008277 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271008278 substrate binding pocket [chemical binding]; other site 331271008279 membrane-bound complex binding site; other site 331271008280 hinge residues; other site 331271008281 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 331271008282 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271008283 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271008284 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 331271008285 Helix-turn-helix domain; Region: HTH_36; pfam13730 331271008286 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 331271008287 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 331271008288 catalytic residues [active] 331271008289 Int/Topo IB signature motif; other site 331271008290 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 331271008291 stringent starvation protein A; Provisional; Region: sspA; PRK09481 331271008292 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 331271008293 C-terminal domain interface [polypeptide binding]; other site 331271008294 putative GSH binding site (G-site) [chemical binding]; other site 331271008295 dimer interface [polypeptide binding]; other site 331271008296 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 331271008297 dimer interface [polypeptide binding]; other site 331271008298 N-terminal domain interface [polypeptide binding]; other site 331271008299 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 331271008300 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 331271008301 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 331271008302 Qi binding site; other site 331271008303 intrachain domain interface; other site 331271008304 interchain domain interface [polypeptide binding]; other site 331271008305 heme bH binding site [chemical binding]; other site 331271008306 heme bL binding site [chemical binding]; other site 331271008307 Qo binding site; other site 331271008308 interchain domain interface [polypeptide binding]; other site 331271008309 intrachain domain interface; other site 331271008310 Qi binding site; other site 331271008311 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 331271008312 Qo binding site; other site 331271008313 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 331271008314 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 331271008315 [2Fe-2S] cluster binding site [ion binding]; other site 331271008316 Uncharacterized conserved protein [Function unknown]; Region: COG0327 331271008317 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 331271008318 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 331271008319 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 331271008320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331271008321 protein binding site [polypeptide binding]; other site 331271008322 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 331271008323 sec-independent translocase; Provisional; Region: tatB; PRK01919 331271008324 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 331271008325 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 331271008326 nucleotide binding site/active site [active] 331271008327 HIT family signature motif; other site 331271008328 catalytic residue [active] 331271008329 Predicted membrane protein [Function unknown]; Region: COG3671 331271008330 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 331271008331 metal binding site [ion binding]; metal-binding site 331271008332 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 331271008333 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 331271008334 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 331271008335 substrate binding site [chemical binding]; other site 331271008336 glutamase interaction surface [polypeptide binding]; other site 331271008337 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 331271008338 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 331271008339 catalytic residues [active] 331271008340 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 331271008341 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 331271008342 putative active site [active] 331271008343 oxyanion strand; other site 331271008344 catalytic triad [active] 331271008345 MarC family integral membrane protein; Region: MarC; cl00919 331271008346 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 331271008347 putative active site pocket [active] 331271008348 4-fold oligomerization interface [polypeptide binding]; other site 331271008349 metal binding residues [ion binding]; metal-binding site 331271008350 3-fold/trimer interface [polypeptide binding]; other site 331271008351 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 331271008352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271008353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271008354 homodimer interface [polypeptide binding]; other site 331271008355 catalytic residue [active] 331271008356 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 331271008357 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 331271008358 NAD binding site [chemical binding]; other site 331271008359 dimerization interface [polypeptide binding]; other site 331271008360 product binding site; other site 331271008361 substrate binding site [chemical binding]; other site 331271008362 zinc binding site [ion binding]; other site 331271008363 catalytic residues [active] 331271008364 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 331271008365 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 331271008366 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 331271008367 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 331271008368 hinge; other site 331271008369 active site 331271008370 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 331271008371 ABC-2 type transporter; Region: ABC2_membrane; cl17235 331271008372 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 331271008373 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 331271008374 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 331271008375 Walker A/P-loop; other site 331271008376 ATP binding site [chemical binding]; other site 331271008377 Q-loop/lid; other site 331271008378 ABC transporter signature motif; other site 331271008379 Walker B; other site 331271008380 D-loop; other site 331271008381 H-loop/switch region; other site 331271008382 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 331271008383 VacJ like lipoprotein; Region: VacJ; cl01073 331271008384 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 331271008385 mce related protein; Region: MCE; pfam02470 331271008386 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 331271008387 Permease; Region: Permease; pfam02405 331271008388 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 331271008389 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 331271008390 Walker A/P-loop; other site 331271008391 ATP binding site [chemical binding]; other site 331271008392 Q-loop/lid; other site 331271008393 ABC transporter signature motif; other site 331271008394 Walker B; other site 331271008395 D-loop; other site 331271008396 H-loop/switch region; other site 331271008397 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 331271008398 thiamine phosphate binding site [chemical binding]; other site 331271008399 active site 331271008400 pyrophosphate binding site [ion binding]; other site 331271008401 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 331271008402 ThiS interaction site; other site 331271008403 putative active site [active] 331271008404 tetramer interface [polypeptide binding]; other site 331271008405 sulfur carrier protein ThiS; Provisional; Region: PRK06944 331271008406 charged pocket; other site 331271008407 hydrophobic patch; other site 331271008408 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 331271008409 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 331271008410 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 331271008411 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 331271008412 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 331271008413 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 331271008414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271008415 NAD(P) binding site [chemical binding]; other site 331271008416 active site 331271008417 benzoate transport; Region: 2A0115; TIGR00895 331271008418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271008419 putative substrate translocation pore; other site 331271008420 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 331271008421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271008422 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 331271008423 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 331271008424 amino acid carrier protein; Region: agcS; TIGR00835 331271008425 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 331271008426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271008427 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271008428 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 331271008429 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 331271008430 active site 331271008431 dimer interface [polypeptide binding]; other site 331271008432 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 331271008433 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331271008434 active site 331271008435 FMN binding site [chemical binding]; other site 331271008436 substrate binding site [chemical binding]; other site 331271008437 3Fe-4S cluster binding site [ion binding]; other site 331271008438 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 331271008439 domain interface; other site 331271008440 Transposase IS200 like; Region: Y1_Tnp; cl00848 331271008441 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 331271008442 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 331271008443 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 331271008444 active site 331271008445 catalytic site [active] 331271008446 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 331271008447 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 331271008448 Walker A/P-loop; other site 331271008449 ATP binding site [chemical binding]; other site 331271008450 Q-loop/lid; other site 331271008451 ABC transporter signature motif; other site 331271008452 Walker B; other site 331271008453 D-loop; other site 331271008454 H-loop/switch region; other site 331271008455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271008456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271008457 dimer interface [polypeptide binding]; other site 331271008458 conserved gate region; other site 331271008459 putative PBP binding loops; other site 331271008460 ABC-ATPase subunit interface; other site 331271008461 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 331271008462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271008463 dimer interface [polypeptide binding]; other site 331271008464 conserved gate region; other site 331271008465 putative PBP binding loops; other site 331271008466 ABC-ATPase subunit interface; other site 331271008467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 331271008468 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 331271008469 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 331271008470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331271008471 Zn2+ binding site [ion binding]; other site 331271008472 Mg2+ binding site [ion binding]; other site 331271008473 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 331271008474 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 331271008475 active site 331271008476 dimer interface [polypeptide binding]; other site 331271008477 metal binding site [ion binding]; metal-binding site 331271008478 shikimate kinase; Reviewed; Region: aroK; PRK00131 331271008479 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 331271008480 ADP binding site [chemical binding]; other site 331271008481 magnesium binding site [ion binding]; other site 331271008482 putative shikimate binding site; other site 331271008483 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331271008484 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 331271008485 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 331271008486 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 331271008487 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 331271008488 Transglycosylase; Region: Transgly; pfam00912 331271008489 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331271008490 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 331271008491 putative iron binding site [ion binding]; other site 331271008492 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 331271008493 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 331271008494 TMAO/DMSO reductase; Reviewed; Region: PRK05363 331271008495 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 331271008496 Moco binding site; other site 331271008497 metal coordination site [ion binding]; other site 331271008498 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 331271008499 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 331271008500 ResB-like family; Region: ResB; pfam05140 331271008501 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 331271008502 ResB-like family; Region: ResB; pfam05140 331271008503 Cytochrome c553 [Energy production and conversion]; Region: COG2863 331271008504 Cytochrome c; Region: Cytochrom_C; cl11414 331271008505 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 331271008506 G1 box; other site 331271008507 GTP/Mg2+ binding site [chemical binding]; other site 331271008508 Switch I region; other site 331271008509 G2 box; other site 331271008510 G3 box; other site 331271008511 Switch II region; other site 331271008512 G4 box; other site 331271008513 G5 box; other site 331271008514 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 331271008515 dimer interface [polypeptide binding]; other site 331271008516 active site 331271008517 aspartate-rich active site metal binding site; other site 331271008518 allosteric magnesium binding site [ion binding]; other site 331271008519 Schiff base residues; other site 331271008520 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 331271008521 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 331271008522 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 331271008523 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 331271008524 DsbD alpha interface [polypeptide binding]; other site 331271008525 catalytic residues [active] 331271008526 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 331271008527 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 331271008528 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 331271008529 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 331271008530 alphaNTD homodimer interface [polypeptide binding]; other site 331271008531 alphaNTD - beta interaction site [polypeptide binding]; other site 331271008532 alphaNTD - beta' interaction site [polypeptide binding]; other site 331271008533 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 331271008534 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 331271008535 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 331271008536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331271008537 RNA binding surface [nucleotide binding]; other site 331271008538 30S ribosomal protein S11; Validated; Region: PRK05309 331271008539 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 331271008540 30S ribosomal protein S13; Region: bact_S13; TIGR03631 331271008541 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 331271008542 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 331271008543 rRNA binding site [nucleotide binding]; other site 331271008544 predicted 30S ribosome binding site; other site 331271008545 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 331271008546 SecY translocase; Region: SecY; pfam00344 331271008547 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 331271008548 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 331271008549 23S rRNA binding site [nucleotide binding]; other site 331271008550 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 331271008551 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 331271008552 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 331271008553 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 331271008554 5S rRNA interface [nucleotide binding]; other site 331271008555 L27 interface [polypeptide binding]; other site 331271008556 23S rRNA interface [nucleotide binding]; other site 331271008557 L5 interface [polypeptide binding]; other site 331271008558 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 331271008559 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331271008560 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331271008561 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 331271008562 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 331271008563 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 331271008564 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 331271008565 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 331271008566 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 331271008567 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 331271008568 RNA binding site [nucleotide binding]; other site 331271008569 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 331271008570 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 331271008571 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 331271008572 23S rRNA interface [nucleotide binding]; other site 331271008573 putative translocon interaction site; other site 331271008574 signal recognition particle (SRP54) interaction site; other site 331271008575 L23 interface [polypeptide binding]; other site 331271008576 trigger factor interaction site; other site 331271008577 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 331271008578 23S rRNA interface [nucleotide binding]; other site 331271008579 5S rRNA interface [nucleotide binding]; other site 331271008580 putative antibiotic binding site [chemical binding]; other site 331271008581 L25 interface [polypeptide binding]; other site 331271008582 L27 interface [polypeptide binding]; other site 331271008583 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 331271008584 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 331271008585 G-X-X-G motif; other site 331271008586 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 331271008587 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 331271008588 putative translocon binding site; other site 331271008589 protein-rRNA interface [nucleotide binding]; other site 331271008590 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 331271008591 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 331271008592 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 331271008593 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 331271008594 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 331271008595 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 331271008596 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 331271008597 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 331271008598 elongation factor Tu; Reviewed; Region: PRK00049 331271008599 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 331271008600 G1 box; other site 331271008601 GEF interaction site [polypeptide binding]; other site 331271008602 GTP/Mg2+ binding site [chemical binding]; other site 331271008603 Switch I region; other site 331271008604 G2 box; other site 331271008605 G3 box; other site 331271008606 Switch II region; other site 331271008607 G4 box; other site 331271008608 G5 box; other site 331271008609 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 331271008610 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 331271008611 Antibiotic Binding Site [chemical binding]; other site 331271008612 elongation factor G; Reviewed; Region: PRK00007 331271008613 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 331271008614 G1 box; other site 331271008615 putative GEF interaction site [polypeptide binding]; other site 331271008616 GTP/Mg2+ binding site [chemical binding]; other site 331271008617 Switch I region; other site 331271008618 G2 box; other site 331271008619 G3 box; other site 331271008620 Switch II region; other site 331271008621 G4 box; other site 331271008622 G5 box; other site 331271008623 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 331271008624 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 331271008625 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 331271008626 30S ribosomal protein S7; Validated; Region: PRK05302 331271008627 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 331271008628 S17 interaction site [polypeptide binding]; other site 331271008629 S8 interaction site; other site 331271008630 16S rRNA interaction site [nucleotide binding]; other site 331271008631 streptomycin interaction site [chemical binding]; other site 331271008632 23S rRNA interaction site [nucleotide binding]; other site 331271008633 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 331271008634 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 331271008635 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331271008636 ATP binding site [chemical binding]; other site 331271008637 putative Mg++ binding site [ion binding]; other site 331271008638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271008639 nucleotide binding region [chemical binding]; other site 331271008640 ATP-binding site [chemical binding]; other site 331271008641 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 331271008642 HRDC domain; Region: HRDC; pfam00570 331271008643 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 331271008644 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 331271008645 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 331271008646 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 331271008647 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 331271008648 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 331271008649 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 331271008650 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 331271008651 DNA binding site [nucleotide binding] 331271008652 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 331271008653 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 331271008654 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 331271008655 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 331271008656 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 331271008657 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331271008658 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 331271008659 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331271008660 RPB3 interaction site [polypeptide binding]; other site 331271008661 RPB1 interaction site [polypeptide binding]; other site 331271008662 RPB11 interaction site [polypeptide binding]; other site 331271008663 RPB10 interaction site [polypeptide binding]; other site 331271008664 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 331271008665 peripheral dimer interface [polypeptide binding]; other site 331271008666 core dimer interface [polypeptide binding]; other site 331271008667 L10 interface [polypeptide binding]; other site 331271008668 L11 interface [polypeptide binding]; other site 331271008669 putative EF-Tu interaction site [polypeptide binding]; other site 331271008670 putative EF-G interaction site [polypeptide binding]; other site 331271008671 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 331271008672 23S rRNA interface [nucleotide binding]; other site 331271008673 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 331271008674 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 331271008675 mRNA/rRNA interface [nucleotide binding]; other site 331271008676 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 331271008677 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 331271008678 23S rRNA interface [nucleotide binding]; other site 331271008679 L7/L12 interface [polypeptide binding]; other site 331271008680 putative thiostrepton binding site; other site 331271008681 L25 interface [polypeptide binding]; other site 331271008682 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 331271008683 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 331271008684 putative homodimer interface [polypeptide binding]; other site 331271008685 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 331271008686 heterodimer interface [polypeptide binding]; other site 331271008687 homodimer interface [polypeptide binding]; other site 331271008688 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 331271008689 elongation factor Tu; Reviewed; Region: PRK00049 331271008690 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 331271008691 G1 box; other site 331271008692 GEF interaction site [polypeptide binding]; other site 331271008693 GTP/Mg2+ binding site [chemical binding]; other site 331271008694 Switch I region; other site 331271008695 G2 box; other site 331271008696 G3 box; other site 331271008697 Switch II region; other site 331271008698 G4 box; other site 331271008699 G5 box; other site 331271008700 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 331271008701 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 331271008702 Antibiotic Binding Site [chemical binding]; other site 331271008703 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 331271008704 active site 331271008705 catalytic triad [active] 331271008706 oxyanion hole [active] 331271008707 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 331271008708 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 331271008709 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 331271008710 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 331271008711 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 331271008712 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 331271008713 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 331271008714 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 331271008715 FAD binding pocket [chemical binding]; other site 331271008716 FAD binding motif [chemical binding]; other site 331271008717 phosphate binding motif [ion binding]; other site 331271008718 beta-alpha-beta structure motif; other site 331271008719 NAD(p) ribose binding residues [chemical binding]; other site 331271008720 NAD binding pocket [chemical binding]; other site 331271008721 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 331271008722 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271008723 catalytic loop [active] 331271008724 iron binding site [ion binding]; other site 331271008725 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 331271008726 Protein of unknown function; Region: DUF3658; pfam12395 331271008727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271008728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271008729 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 331271008730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271008731 Coenzyme A binding pocket [chemical binding]; other site 331271008732 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271008733 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271008734 putative DNA binding site [nucleotide binding]; other site 331271008735 putative Zn2+ binding site [ion binding]; other site 331271008736 AsnC family; Region: AsnC_trans_reg; pfam01037 331271008737 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 331271008738 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 331271008739 dimer interface [polypeptide binding]; other site 331271008740 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 331271008741 active site 331271008742 Fe binding site [ion binding]; other site 331271008743 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 331271008744 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331271008745 dimer interface [polypeptide binding]; other site 331271008746 PYR/PP interface [polypeptide binding]; other site 331271008747 TPP binding site [chemical binding]; other site 331271008748 substrate binding site [chemical binding]; other site 331271008749 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 331271008750 TPP-binding site; other site 331271008751 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 331271008752 Sfi1 spindle body protein; Region: Sfi1; pfam08457 331271008753 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 331271008754 Malic enzyme, N-terminal domain; Region: malic; pfam00390 331271008755 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 331271008756 putative NAD(P) binding site [chemical binding]; other site 331271008757 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 331271008758 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271008759 active site 331271008760 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 331271008761 substrate binding site [chemical binding]; other site 331271008762 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 331271008763 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271008764 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 331271008765 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 331271008766 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 331271008767 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 331271008768 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 331271008769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271008770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271008771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271008772 dimerization interface [polypeptide binding]; other site 331271008773 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271008774 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271008775 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 331271008776 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271008777 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 331271008778 Uncharacterized conserved protein [Function unknown]; Region: COG1656 331271008779 Protein of unknown function DUF82; Region: DUF82; pfam01927 331271008780 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271008781 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271008782 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331271008783 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331271008784 Walker A/P-loop; other site 331271008785 ATP binding site [chemical binding]; other site 331271008786 Q-loop/lid; other site 331271008787 ABC transporter signature motif; other site 331271008788 Walker B; other site 331271008789 D-loop; other site 331271008790 H-loop/switch region; other site 331271008791 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331271008792 FtsX-like permease family; Region: FtsX; pfam02687 331271008793 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 331271008794 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 331271008795 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 331271008796 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271008797 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 331271008798 C-terminal domain interface [polypeptide binding]; other site 331271008799 GSH binding site (G-site) [chemical binding]; other site 331271008800 dimer interface [polypeptide binding]; other site 331271008801 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 331271008802 N-terminal domain interface [polypeptide binding]; other site 331271008803 dimer interface [polypeptide binding]; other site 331271008804 substrate binding pocket (H-site) [chemical binding]; other site 331271008805 LysR family transcriptional regulator; Provisional; Region: PRK14997 331271008806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271008807 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271008808 putative effector binding pocket; other site 331271008809 dimerization interface [polypeptide binding]; other site 331271008810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271008811 D-galactonate transporter; Region: 2A0114; TIGR00893 331271008812 putative substrate translocation pore; other site 331271008813 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 331271008814 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 331271008815 active site 331271008816 tetramer interface [polypeptide binding]; other site 331271008817 Cytochrome c; Region: Cytochrom_C; cl11414 331271008818 outer membrane lipoprotein; Provisional; Region: PRK11023 331271008819 BON domain; Region: BON; pfam04972 331271008820 BON domain; Region: BON; cl02771 331271008821 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 331271008822 active site 331271008823 dimer interface [polypeptide binding]; other site 331271008824 hypothetical protein; Provisional; Region: PRK14673 331271008825 Predicted methyltransferases [General function prediction only]; Region: COG0313 331271008826 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 331271008827 putative SAM binding site [chemical binding]; other site 331271008828 putative homodimer interface [polypeptide binding]; other site 331271008829 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 331271008830 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 331271008831 putative active site [active] 331271008832 putative NTP binding site [chemical binding]; other site 331271008833 putative nucleic acid binding site [nucleotide binding]; other site 331271008834 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 331271008835 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 331271008836 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 331271008837 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 331271008838 active site 331271008839 catalytic site [active] 331271008840 substrate binding site [chemical binding]; other site 331271008841 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 331271008842 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271008843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271008844 putative DNA binding site [nucleotide binding]; other site 331271008845 putative Zn2+ binding site [ion binding]; other site 331271008846 AsnC family; Region: AsnC_trans_reg; pfam01037 331271008847 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 331271008848 Cation efflux family; Region: Cation_efflux; pfam01545 331271008849 H-NS histone family; Region: Histone_HNS; pfam00816 331271008850 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 331271008851 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 331271008852 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 331271008853 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271008854 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271008855 dimerization interface [polypeptide binding]; other site 331271008856 ligand binding site [chemical binding]; other site 331271008857 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 331271008858 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 331271008859 FMN binding site [chemical binding]; other site 331271008860 substrate binding site [chemical binding]; other site 331271008861 putative catalytic residue [active] 331271008862 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 331271008863 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 331271008864 Amidase; Region: Amidase; cl11426 331271008865 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 331271008866 FAD binding site [chemical binding]; other site 331271008867 Predicted membrane protein [Function unknown]; Region: COG1950 331271008868 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 331271008869 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 331271008870 homotetramer interface [polypeptide binding]; other site 331271008871 ligand binding site [chemical binding]; other site 331271008872 catalytic site [active] 331271008873 NAD binding site [chemical binding]; other site 331271008874 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 331271008875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271008876 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331271008877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271008878 DNA binding residues [nucleotide binding] 331271008879 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 331271008880 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 331271008881 P-loop; other site 331271008882 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 331271008883 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331271008884 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 331271008885 FHIPEP family; Region: FHIPEP; pfam00771 331271008886 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 331271008887 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 331271008888 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 331271008889 dimer interface [polypeptide binding]; other site 331271008890 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 331271008891 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 331271008892 chemotaxis regulator CheZ; Provisional; Region: PRK11166 331271008893 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 331271008894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271008895 active site 331271008896 phosphorylation site [posttranslational modification] 331271008897 intermolecular recognition site; other site 331271008898 dimerization interface [polypeptide binding]; other site 331271008899 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 331271008900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271008901 active site 331271008902 phosphorylation site [posttranslational modification] 331271008903 intermolecular recognition site; other site 331271008904 dimerization interface [polypeptide binding]; other site 331271008905 CheB methylesterase; Region: CheB_methylest; pfam01339 331271008906 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 331271008907 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 331271008908 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 331271008909 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 331271008910 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 331271008911 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 331271008912 dimer interface [polypeptide binding]; other site 331271008913 ligand binding site [chemical binding]; other site 331271008914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271008915 dimerization interface [polypeptide binding]; other site 331271008916 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271008917 dimer interface [polypeptide binding]; other site 331271008918 putative CheW interface [polypeptide binding]; other site 331271008919 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 331271008920 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 331271008921 putative binding surface; other site 331271008922 active site 331271008923 CheY binding; Region: CheY-binding; pfam09078 331271008924 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 331271008925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271008926 ATP binding site [chemical binding]; other site 331271008927 Mg2+ binding site [ion binding]; other site 331271008928 G-X-G motif; other site 331271008929 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 331271008930 Response regulator receiver domain; Region: Response_reg; pfam00072 331271008931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271008932 active site 331271008933 phosphorylation site [posttranslational modification] 331271008934 intermolecular recognition site; other site 331271008935 dimerization interface [polypeptide binding]; other site 331271008936 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 331271008937 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 331271008938 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271008939 ligand binding site [chemical binding]; other site 331271008940 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 331271008941 flagellar motor protein MotA; Validated; Region: PRK09110 331271008942 transcriptional activator FlhC; Provisional; Region: PRK12722 331271008943 transcriptional activator FlhD; Provisional; Region: PRK02909 331271008944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271008945 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 331271008946 putative ADP-binding pocket [chemical binding]; other site 331271008947 H-NS histone family; Region: Histone_HNS; pfam00816 331271008948 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 331271008949 amphipathic channel; other site 331271008950 Asn-Pro-Ala signature motifs; other site 331271008951 putative hydrolase; Provisional; Region: PRK10976 331271008952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271008953 active site 331271008954 motif I; other site 331271008955 motif II; other site 331271008956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 331271008957 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 331271008958 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 331271008959 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271008960 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271008961 N-terminal plug; other site 331271008962 ligand-binding site [chemical binding]; other site 331271008963 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 331271008964 flagellin; Reviewed; Region: PRK08869 331271008965 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 331271008966 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 331271008967 flagellar capping protein; Reviewed; Region: fliD; PRK08032 331271008968 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 331271008969 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331271008970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271008971 TPR motif; other site 331271008972 binding surface 331271008973 TPR repeat; Region: TPR_11; pfam13414 331271008974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271008975 TPR motif; other site 331271008976 binding surface 331271008977 TPR repeat; Region: TPR_11; pfam13414 331271008978 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 331271008979 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 331271008980 inhibitor-cofactor binding pocket; inhibition site 331271008981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271008982 catalytic residue [active] 331271008983 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271008984 Methyltransferase domain; Region: Methyltransf_23; pfam13489 331271008985 WbqC-like protein family; Region: WbqC; pfam08889 331271008986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271008987 TPR motif; other site 331271008988 binding surface 331271008989 TPR repeat; Region: TPR_11; pfam13414 331271008990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271008991 binding surface 331271008992 TPR motif; other site 331271008993 TPR repeat; Region: TPR_11; pfam13414 331271008994 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271008995 Uncharacterized conserved protein [Function unknown]; Region: COG4278 331271008996 TIGR04222 domain; Region: near_uncomplex 331271008997 Domain of unknown function (DUF955); Region: DUF955; pfam06114 331271008998 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 331271008999 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 331271009000 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 331271009001 DEAD/DEAH box helicase; Region: DEAD; pfam00270 331271009002 helicase superfamily c-terminal domain; Region: HELICc; smart00490 331271009003 ATP-binding site [chemical binding]; other site 331271009004 Methyltransferase domain; Region: Methyltransf_26; pfam13659 331271009005 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 331271009006 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 331271009007 Integrase core domain; Region: rve; pfam00665 331271009008 AAA domain; Region: AAA_22; pfam13401 331271009009 TniQ; Region: TniQ; pfam06527 331271009010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271009011 sequence-specific DNA binding site [nucleotide binding]; other site 331271009012 salt bridge; other site 331271009013 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 331271009014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331271009015 Integrase core domain; Region: rve; pfam00665 331271009016 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331271009017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271009018 Walker A motif; other site 331271009019 ATP binding site [chemical binding]; other site 331271009020 Walker B motif; other site 331271009021 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 331271009022 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 331271009023 DNA binding site [nucleotide binding] 331271009024 active site 331271009025 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 331271009026 Uncharacterized conserved protein [Function unknown]; Region: COG2128 331271009027 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271009028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271009029 DNA-binding site [nucleotide binding]; DNA binding site 331271009030 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271009031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271009032 homodimer interface [polypeptide binding]; other site 331271009033 catalytic residue [active] 331271009034 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 331271009035 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 331271009036 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 331271009037 Part of AAA domain; Region: AAA_19; pfam13245 331271009038 Family description; Region: UvrD_C_2; pfam13538 331271009039 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 331271009040 active site 331271009041 catalytic triad [active] 331271009042 oxyanion hole [active] 331271009043 putative oxidoreductase; Provisional; Region: PRK11579 331271009044 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 331271009045 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 331271009046 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 331271009047 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 331271009048 lipoyl attachment site [posttranslational modification]; other site 331271009049 glycine dehydrogenase; Provisional; Region: PRK05367 331271009050 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271009051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271009052 catalytic residue [active] 331271009053 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 331271009054 tetramer interface [polypeptide binding]; other site 331271009055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271009056 catalytic residue [active] 331271009057 Alginate lyase; Region: Alginate_lyase; pfam05426 331271009058 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 331271009059 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 331271009060 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 331271009061 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 331271009062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 331271009063 thiamine pyrophosphate protein; Validated; Region: PRK08199 331271009064 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271009065 PYR/PP interface [polypeptide binding]; other site 331271009066 dimer interface [polypeptide binding]; other site 331271009067 TPP binding site [chemical binding]; other site 331271009068 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271009069 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 331271009070 TPP-binding site [chemical binding]; other site 331271009071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271009072 transcriptional regulator EutR; Provisional; Region: PRK10130 331271009073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271009074 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 331271009075 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 331271009076 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271009077 NAD(P) binding site [chemical binding]; other site 331271009078 catalytic residues [active] 331271009079 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 331271009080 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271009081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009084 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 331271009085 putative effector binding pocket; other site 331271009086 putative dimerization interface [polypeptide binding]; other site 331271009087 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 331271009088 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 331271009089 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 331271009090 ethanolamine permease; Region: 2A0305; TIGR00908 331271009091 hypothetical protein; Provisional; Region: PHA02764 331271009092 Conserved TM helix; Region: TM_helix; pfam05552 331271009093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271009094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271009095 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 331271009096 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 331271009097 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 331271009098 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 331271009099 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331271009100 Soluble P-type ATPase [General function prediction only]; Region: COG4087 331271009101 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 331271009102 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 331271009103 DNA binding residues [nucleotide binding] 331271009104 dimer interface [polypeptide binding]; other site 331271009105 putative metal binding site [ion binding]; other site 331271009106 Predicted transcriptional regulators [Transcription]; Region: COG1695 331271009107 Transcriptional regulator PadR-like family; Region: PadR; cl17335 331271009108 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331271009109 FAD binding domain; Region: FAD_binding_4; pfam01565 331271009110 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 331271009111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271009112 substrate binding pocket [chemical binding]; other site 331271009113 membrane-bound complex binding site; other site 331271009114 putative aminotransferase; Provisional; Region: PRK12414 331271009115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271009116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271009117 homodimer interface [polypeptide binding]; other site 331271009118 catalytic residue [active] 331271009119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271009120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271009121 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 331271009122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271009123 active site 331271009124 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 331271009125 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271009126 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 331271009127 acyl-activating enzyme (AAE) consensus motif; other site 331271009128 acyl-activating enzyme (AAE) consensus motif; other site 331271009129 putative AMP binding site [chemical binding]; other site 331271009130 putative active site [active] 331271009131 putative CoA binding site [chemical binding]; other site 331271009132 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271009133 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271009134 dimerization interface [polypeptide binding]; other site 331271009135 ligand binding site [chemical binding]; other site 331271009136 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 331271009137 Predicted transcriptional regulator [Transcription]; Region: COG3905 331271009138 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 331271009139 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 331271009140 Glutamate binding site [chemical binding]; other site 331271009141 NAD binding site [chemical binding]; other site 331271009142 catalytic residues [active] 331271009143 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 331271009144 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 331271009145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331271009146 ATP binding site [chemical binding]; other site 331271009147 putative Mg++ binding site [ion binding]; other site 331271009148 helicase superfamily c-terminal domain; Region: HELICc; smart00490 331271009149 ATP-binding site [chemical binding]; other site 331271009150 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 331271009151 substrate binding site [chemical binding]; other site 331271009152 active site 331271009153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271009154 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271009155 substrate binding pocket [chemical binding]; other site 331271009156 membrane-bound complex binding site; other site 331271009157 hinge residues; other site 331271009158 AMP-binding domain protein; Validated; Region: PRK08315 331271009159 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271009160 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 331271009161 acyl-activating enzyme (AAE) consensus motif; other site 331271009162 putative AMP binding site [chemical binding]; other site 331271009163 putative active site [active] 331271009164 putative CoA binding site [chemical binding]; other site 331271009165 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 331271009166 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 331271009167 gamma subunit interface [polypeptide binding]; other site 331271009168 epsilon subunit interface [polypeptide binding]; other site 331271009169 LBP interface [polypeptide binding]; other site 331271009170 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 331271009171 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 331271009172 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 331271009173 alpha subunit interaction interface [polypeptide binding]; other site 331271009174 Walker A motif; other site 331271009175 ATP binding site [chemical binding]; other site 331271009176 Walker B motif; other site 331271009177 inhibitor binding site; inhibition site 331271009178 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 331271009179 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 331271009180 core domain interface [polypeptide binding]; other site 331271009181 delta subunit interface [polypeptide binding]; other site 331271009182 epsilon subunit interface [polypeptide binding]; other site 331271009183 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 331271009184 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 331271009185 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 331271009186 beta subunit interaction interface [polypeptide binding]; other site 331271009187 Walker A motif; other site 331271009188 ATP binding site [chemical binding]; other site 331271009189 Walker B motif; other site 331271009190 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 331271009191 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 331271009192 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 331271009193 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 331271009194 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 331271009195 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 331271009196 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 331271009197 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 331271009198 ATP synthase I chain; Region: ATP_synt_I; cl09170 331271009199 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 331271009200 transmembrane helices; other site 331271009201 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 331271009202 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 331271009203 ParB-like nuclease domain; Region: ParBc; pfam02195 331271009204 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331271009205 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271009206 P-loop; other site 331271009207 Magnesium ion binding site [ion binding]; other site 331271009208 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271009209 Magnesium ion binding site [ion binding]; other site 331271009210 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 331271009211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271009212 S-adenosylmethionine binding site [chemical binding]; other site 331271009213 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 331271009214 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 331271009215 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 331271009216 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 331271009217 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331271009218 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271009219 Walker A/P-loop; other site 331271009220 ATP binding site [chemical binding]; other site 331271009221 Q-loop/lid; other site 331271009222 ABC transporter signature motif; other site 331271009223 Walker B; other site 331271009224 D-loop; other site 331271009225 H-loop/switch region; other site 331271009226 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331271009227 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271009228 TM-ABC transporter signature motif; other site 331271009229 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331271009230 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271009231 Walker A/P-loop; other site 331271009232 ATP binding site [chemical binding]; other site 331271009233 Q-loop/lid; other site 331271009234 ABC transporter signature motif; other site 331271009235 Walker B; other site 331271009236 D-loop; other site 331271009237 H-loop/switch region; other site 331271009238 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271009239 TM-ABC transporter signature motif; other site 331271009240 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271009241 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 331271009242 putative ligand binding site [chemical binding]; other site 331271009243 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331271009244 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271009245 TM-ABC transporter signature motif; other site 331271009246 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271009247 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271009248 TM-ABC transporter signature motif; other site 331271009249 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 331271009250 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 331271009251 putative ligand binding site [chemical binding]; other site 331271009252 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331271009253 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271009254 Walker A/P-loop; other site 331271009255 ATP binding site [chemical binding]; other site 331271009256 Q-loop/lid; other site 331271009257 ABC transporter signature motif; other site 331271009258 Walker B; other site 331271009259 D-loop; other site 331271009260 H-loop/switch region; other site 331271009261 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331271009262 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271009263 Walker A/P-loop; other site 331271009264 ATP binding site [chemical binding]; other site 331271009265 Q-loop/lid; other site 331271009266 ABC transporter signature motif; other site 331271009267 Walker B; other site 331271009268 D-loop; other site 331271009269 H-loop/switch region; other site 331271009270 choline dehydrogenase; Validated; Region: PRK02106 331271009271 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271009272 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009274 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271009275 dimerization interface [polypeptide binding]; other site 331271009276 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 331271009277 putative active site [active] 331271009278 putative metal binding residues [ion binding]; other site 331271009279 signature motif; other site 331271009280 putative triphosphate binding site [ion binding]; other site 331271009281 dimer interface [polypeptide binding]; other site 331271009282 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271009283 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 331271009284 putative DNA binding site [nucleotide binding]; other site 331271009285 putative Zn2+ binding site [ion binding]; other site 331271009286 AsnC family; Region: AsnC_trans_reg; pfam01037 331271009287 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 331271009288 cofactor binding site; other site 331271009289 metal binding site [ion binding]; metal-binding site 331271009290 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 331271009291 aromatic arch; other site 331271009292 DCoH dimer interaction site [polypeptide binding]; other site 331271009293 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 331271009294 DCoH tetramer interaction site [polypeptide binding]; other site 331271009295 substrate binding site [chemical binding]; other site 331271009296 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 331271009297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271009298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271009299 active site 331271009300 phosphorylation site [posttranslational modification] 331271009301 intermolecular recognition site; other site 331271009302 dimerization interface [polypeptide binding]; other site 331271009303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271009304 DNA binding site [nucleotide binding] 331271009305 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 331271009306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271009307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271009308 dimer interface [polypeptide binding]; other site 331271009309 phosphorylation site [posttranslational modification] 331271009310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271009311 ATP binding site [chemical binding]; other site 331271009312 Mg2+ binding site [ion binding]; other site 331271009313 G-X-G motif; other site 331271009314 Proteins containing SET domain [General function prediction only]; Region: COG2940 331271009315 SET domain; Region: SET; pfam00856 331271009316 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271009317 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 331271009318 active site 331271009319 FMN binding site [chemical binding]; other site 331271009320 substrate binding site [chemical binding]; other site 331271009321 homotetramer interface [polypeptide binding]; other site 331271009322 catalytic residue [active] 331271009323 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 331271009324 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 331271009325 catalytic triad [active] 331271009326 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271009327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271009328 putative DNA binding site [nucleotide binding]; other site 331271009329 putative Zn2+ binding site [ion binding]; other site 331271009330 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271009331 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271009332 Cytochrome c; Region: Cytochrom_C; pfam00034 331271009333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009335 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271009336 putative effector binding pocket; other site 331271009337 dimerization interface [polypeptide binding]; other site 331271009338 classical (c) SDRs; Region: SDR_c; cd05233 331271009339 short chain dehydrogenase; Provisional; Region: PRK07041 331271009340 NAD(P) binding site [chemical binding]; other site 331271009341 active site 331271009342 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271009343 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331271009344 FMN binding site [chemical binding]; other site 331271009345 active site 331271009346 substrate binding site [chemical binding]; other site 331271009347 catalytic residue [active] 331271009348 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271009349 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271009350 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 331271009351 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331271009352 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 331271009353 metal binding site [ion binding]; metal-binding site 331271009354 putative dimer interface [polypeptide binding]; other site 331271009355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009356 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271009357 putative substrate translocation pore; other site 331271009358 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 331271009359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009360 LysR substrate binding domain; Region: LysR_substrate; pfam03466 331271009361 dimerization interface [polypeptide binding]; other site 331271009362 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 331271009363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271009364 substrate binding pocket [chemical binding]; other site 331271009365 membrane-bound complex binding site; other site 331271009366 hinge residues; other site 331271009367 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 331271009368 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 331271009369 active site 331271009370 Zn binding site [ion binding]; other site 331271009371 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 331271009372 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271009373 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271009374 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 331271009375 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271009376 dimer interface [polypeptide binding]; other site 331271009377 active site 331271009378 Uncharacterized conserved protein [Function unknown]; Region: COG1683 331271009379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271009380 Coenzyme A binding pocket [chemical binding]; other site 331271009381 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331271009382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271009383 S-adenosylmethionine binding site [chemical binding]; other site 331271009384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271009385 PAS domain; Region: PAS_9; pfam13426 331271009386 putative active site [active] 331271009387 heme pocket [chemical binding]; other site 331271009388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 331271009389 dimerization interface [polypeptide binding]; other site 331271009390 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271009391 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271009392 dimer interface [polypeptide binding]; other site 331271009393 putative CheW interface [polypeptide binding]; other site 331271009394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271009395 PAS domain; Region: PAS_9; pfam13426 331271009396 putative active site [active] 331271009397 heme pocket [chemical binding]; other site 331271009398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271009399 dimerization interface [polypeptide binding]; other site 331271009400 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271009401 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271009402 dimer interface [polypeptide binding]; other site 331271009403 putative CheW interface [polypeptide binding]; other site 331271009404 succinic semialdehyde dehydrogenase; Region: PLN02278 331271009405 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 331271009406 tetramerization interface [polypeptide binding]; other site 331271009407 NAD(P) binding site [chemical binding]; other site 331271009408 catalytic residues [active] 331271009409 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 331271009410 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271009411 inhibitor-cofactor binding pocket; inhibition site 331271009412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271009413 catalytic residue [active] 331271009414 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271009415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271009416 DNA-binding site [nucleotide binding]; DNA binding site 331271009417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271009418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271009419 homodimer interface [polypeptide binding]; other site 331271009420 catalytic residue [active] 331271009421 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 331271009422 selenophosphate synthetase; Provisional; Region: PRK00943 331271009423 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 331271009424 dimerization interface [polypeptide binding]; other site 331271009425 putative ATP binding site [chemical binding]; other site 331271009426 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271009427 Purine nucleoside permease (NUP); Region: NUP; pfam06516 331271009428 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271009429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009431 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271009432 putative effector binding pocket; other site 331271009433 putative dimerization interface [polypeptide binding]; other site 331271009434 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 331271009435 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271009436 substrate binding pocket [chemical binding]; other site 331271009437 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271009438 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271009439 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271009440 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 331271009441 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271009442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271009445 dimerization interface [polypeptide binding]; other site 331271009446 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 331271009447 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 331271009448 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271009449 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271009450 catalytic site [active] 331271009451 MarR family; Region: MarR_2; cl17246 331271009452 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 331271009453 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 331271009454 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331271009455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271009456 active site 331271009457 phosphorylation site [posttranslational modification] 331271009458 intermolecular recognition site; other site 331271009459 dimerization interface [polypeptide binding]; other site 331271009460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271009461 Walker A motif; other site 331271009462 ATP binding site [chemical binding]; other site 331271009463 Walker B motif; other site 331271009464 arginine finger; other site 331271009465 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271009466 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 331271009467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271009468 dimer interface [polypeptide binding]; other site 331271009469 phosphorylation site [posttranslational modification] 331271009470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271009471 ATP binding site [chemical binding]; other site 331271009472 Mg2+ binding site [ion binding]; other site 331271009473 G-X-G motif; other site 331271009474 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 331271009475 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 331271009476 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 331271009477 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 331271009478 active site 331271009479 non-prolyl cis peptide bond; other site 331271009480 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 331271009481 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 331271009482 Walker A/P-loop; other site 331271009483 ATP binding site [chemical binding]; other site 331271009484 Q-loop/lid; other site 331271009485 ABC transporter signature motif; other site 331271009486 Walker B; other site 331271009487 D-loop; other site 331271009488 H-loop/switch region; other site 331271009489 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 331271009490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271009491 dimer interface [polypeptide binding]; other site 331271009492 conserved gate region; other site 331271009493 ABC-ATPase subunit interface; other site 331271009494 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 331271009495 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 331271009496 Flavin binding site [chemical binding]; other site 331271009497 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 331271009498 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 331271009499 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 331271009500 putative GTP cyclohydrolase; Provisional; Region: PRK13674 331271009501 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 331271009502 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 331271009503 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 331271009504 trimer interface [polypeptide binding]; other site 331271009505 active site 331271009506 dihydroorotase; Validated; Region: PRK09060 331271009507 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271009508 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 331271009509 active site 331271009510 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271009511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271009512 putative DNA binding site [nucleotide binding]; other site 331271009513 putative Zn2+ binding site [ion binding]; other site 331271009514 AsnC family; Region: AsnC_trans_reg; pfam01037 331271009515 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271009516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271009517 non-specific DNA binding site [nucleotide binding]; other site 331271009518 salt bridge; other site 331271009519 sequence-specific DNA binding site [nucleotide binding]; other site 331271009520 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 331271009521 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 331271009522 Peptidase family M50; Region: Peptidase_M50; pfam02163 331271009523 active site 331271009524 putative substrate binding region [chemical binding]; other site 331271009525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009526 D-galactonate transporter; Region: 2A0114; TIGR00893 331271009527 putative substrate translocation pore; other site 331271009528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009529 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 331271009530 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 331271009531 dimer interface [polypeptide binding]; other site 331271009532 NADP binding site [chemical binding]; other site 331271009533 catalytic residues [active] 331271009534 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 331271009535 putative active site [active] 331271009536 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 331271009537 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271009538 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 331271009539 putative active site [active] 331271009540 catalytic residue [active] 331271009541 galactarate dehydratase; Region: galactar-dH20; TIGR03248 331271009542 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 331271009543 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 331271009544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271009545 dimerization interface [polypeptide binding]; other site 331271009546 putative DNA binding site [nucleotide binding]; other site 331271009547 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271009548 putative Zn2+ binding site [ion binding]; other site 331271009549 AsnC family; Region: AsnC_trans_reg; pfam01037 331271009550 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271009551 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271009552 dimerization interface [polypeptide binding]; other site 331271009553 ligand binding site [chemical binding]; other site 331271009554 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 331271009555 active site 331271009556 catalytic residues [active] 331271009557 metal binding site [ion binding]; metal-binding site 331271009558 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 331271009559 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 331271009560 homodimer interface [polypeptide binding]; other site 331271009561 substrate-cofactor binding pocket; other site 331271009562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271009563 catalytic residue [active] 331271009564 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271009565 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 331271009566 Predicted membrane protein [Function unknown]; Region: COG2259 331271009567 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271009568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009569 putative substrate translocation pore; other site 331271009570 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271009571 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271009572 dimerization interface [polypeptide binding]; other site 331271009573 ligand binding site [chemical binding]; other site 331271009574 PAS fold; Region: PAS_4; pfam08448 331271009575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271009576 putative active site [active] 331271009577 heme pocket [chemical binding]; other site 331271009578 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271009579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271009580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271009581 SPRY-associated domain; Region: PRY; cl02686 331271009582 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 331271009583 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 331271009584 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 331271009585 dimer interface [polypeptide binding]; other site 331271009586 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 331271009587 active site 331271009588 Fe binding site [ion binding]; other site 331271009589 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 331271009590 Dehydroquinase class II; Region: DHquinase_II; pfam01220 331271009591 active site 331271009592 trimer interface [polypeptide binding]; other site 331271009593 dimer interface [polypeptide binding]; other site 331271009594 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 331271009595 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 331271009596 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 331271009597 shikimate binding site; other site 331271009598 NAD(P) binding site [chemical binding]; other site 331271009599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009600 D-galactonate transporter; Region: 2A0114; TIGR00893 331271009601 putative substrate translocation pore; other site 331271009602 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 331271009603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271009604 catalytic residue [active] 331271009605 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 331271009606 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271009607 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 331271009608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271009609 Walker A/P-loop; other site 331271009610 ATP binding site [chemical binding]; other site 331271009611 Q-loop/lid; other site 331271009612 ABC transporter signature motif; other site 331271009613 Walker B; other site 331271009614 D-loop; other site 331271009615 H-loop/switch region; other site 331271009616 TOBE domain; Region: TOBE_2; pfam08402 331271009617 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 331271009618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271009619 dimer interface [polypeptide binding]; other site 331271009620 conserved gate region; other site 331271009621 putative PBP binding loops; other site 331271009622 ABC-ATPase subunit interface; other site 331271009623 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271009624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271009625 conserved gate region; other site 331271009626 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 331271009627 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 331271009628 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 331271009629 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 331271009630 NAD(P) binding site [chemical binding]; other site 331271009631 catalytic residues [active] 331271009632 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 331271009633 putative transporter; Provisional; Region: PRK10504 331271009634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009635 putative substrate translocation pore; other site 331271009636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 331271009637 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 331271009638 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 331271009639 catalytic core [active] 331271009640 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 331271009641 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 331271009642 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 331271009643 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 331271009644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009645 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 331271009646 putative dimerization interface [polypeptide binding]; other site 331271009647 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 331271009648 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 331271009649 THF binding site; other site 331271009650 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 331271009651 substrate binding site [chemical binding]; other site 331271009652 THF binding site; other site 331271009653 zinc-binding site [ion binding]; other site 331271009654 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271009655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009656 putative substrate translocation pore; other site 331271009657 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 331271009658 agmatinase; Region: agmatinase; TIGR01230 331271009659 oligomer interface [polypeptide binding]; other site 331271009660 putative active site [active] 331271009661 Mn binding site [ion binding]; other site 331271009662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271009665 dimerization interface [polypeptide binding]; other site 331271009666 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271009667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271009668 putative DNA binding site [nucleotide binding]; other site 331271009669 putative Zn2+ binding site [ion binding]; other site 331271009670 AsnC family; Region: AsnC_trans_reg; pfam01037 331271009671 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271009672 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 331271009673 peptidase domain interface [polypeptide binding]; other site 331271009674 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 331271009675 active site 331271009676 catalytic triad [active] 331271009677 calcium binding site [ion binding]; other site 331271009678 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 331271009679 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 331271009680 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 331271009681 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 331271009682 homodimer interface [polypeptide binding]; other site 331271009683 NAD binding pocket [chemical binding]; other site 331271009684 ATP binding pocket [chemical binding]; other site 331271009685 Mg binding site [ion binding]; other site 331271009686 active-site loop [active] 331271009687 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 331271009688 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 331271009689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 331271009690 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271009691 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 331271009692 putative active site [active] 331271009693 catalytic site [active] 331271009694 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 331271009695 putative active site [active] 331271009696 catalytic site [active] 331271009697 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271009698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271009699 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271009700 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271009701 lysine transporter; Provisional; Region: PRK10836 331271009702 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 331271009703 aldehyde dehydrogenase family 7 member; Region: PLN02315 331271009704 tetrameric interface [polypeptide binding]; other site 331271009705 NAD binding site [chemical binding]; other site 331271009706 catalytic residues [active] 331271009707 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 331271009708 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 331271009709 putative active site [active] 331271009710 putative NTP binding site [chemical binding]; other site 331271009711 putative nucleic acid binding site [nucleotide binding]; other site 331271009712 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 331271009713 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 331271009714 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 331271009715 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271009716 benzoate transport; Region: 2A0115; TIGR00895 331271009717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009719 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271009720 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271009721 trimer interface [polypeptide binding]; other site 331271009722 eyelet of channel; other site 331271009723 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 331271009724 active site 331271009725 tetramer interface [polypeptide binding]; other site 331271009726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271009729 dimerization interface [polypeptide binding]; other site 331271009730 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 331271009731 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 331271009732 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271009733 active site 331271009734 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 331271009735 Transglycosylase; Region: Transgly; pfam00912 331271009736 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331271009737 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271009738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271009739 DNA-binding site [nucleotide binding]; DNA binding site 331271009740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271009741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271009742 homodimer interface [polypeptide binding]; other site 331271009743 catalytic residue [active] 331271009744 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 331271009745 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 331271009746 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271009747 catalytic residues [active] 331271009748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271009749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271009750 active site 331271009751 phosphorylation site [posttranslational modification] 331271009752 intermolecular recognition site; other site 331271009753 dimerization interface [polypeptide binding]; other site 331271009754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271009755 DNA binding site [nucleotide binding] 331271009756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271009757 dimerization interface [polypeptide binding]; other site 331271009758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271009759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271009760 ATP binding site [chemical binding]; other site 331271009761 Mg2+ binding site [ion binding]; other site 331271009762 G-X-G motif; other site 331271009763 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271009764 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271009765 catalytic site [active] 331271009766 TAP-like protein; Region: Abhydrolase_4; pfam08386 331271009767 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 331271009768 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331271009769 active site 331271009770 metal binding site [ion binding]; metal-binding site 331271009771 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 331271009772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271009773 Coenzyme A binding pocket [chemical binding]; other site 331271009774 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271009775 Probable transposase; Region: OrfB_IS605; pfam01385 331271009776 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271009777 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271009778 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271009779 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271009780 eyelet of channel; other site 331271009781 trimer interface [polypeptide binding]; other site 331271009782 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 331271009783 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271009784 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271009785 N-terminal plug; other site 331271009786 ligand-binding site [chemical binding]; other site 331271009787 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 331271009788 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 331271009789 FMN-binding pocket [chemical binding]; other site 331271009790 flavin binding motif; other site 331271009791 phosphate binding motif [ion binding]; other site 331271009792 beta-alpha-beta structure motif; other site 331271009793 NAD binding pocket [chemical binding]; other site 331271009794 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271009795 catalytic loop [active] 331271009796 iron binding site [ion binding]; other site 331271009797 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 331271009798 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 331271009799 iron-sulfur cluster [ion binding]; other site 331271009800 [2Fe-2S] cluster binding site [ion binding]; other site 331271009801 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 331271009802 alpha subunit interface [polypeptide binding]; other site 331271009803 active site 331271009804 substrate binding site [chemical binding]; other site 331271009805 Fe binding site [ion binding]; other site 331271009806 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271009807 MarR family; Region: MarR; pfam01047 331271009808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271009809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271009810 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 331271009811 isovaleryl-CoA dehydrogenase; Region: PLN02519 331271009812 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 331271009813 substrate binding site [chemical binding]; other site 331271009814 FAD binding site [chemical binding]; other site 331271009815 catalytic base [active] 331271009816 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 331271009817 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 331271009818 enoyl-CoA hydratase; Provisional; Region: PRK05995 331271009819 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271009820 substrate binding site [chemical binding]; other site 331271009821 oxyanion hole (OAH) forming residues; other site 331271009822 trimer interface [polypeptide binding]; other site 331271009823 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 331271009824 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331271009825 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331271009826 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 331271009827 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331271009828 carboxyltransferase (CT) interaction site; other site 331271009829 biotinylation site [posttranslational modification]; other site 331271009830 Transposase domain (DUF772); Region: DUF772; pfam05598 331271009831 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331271009832 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 331271009833 Phosphoesterase family; Region: Phosphoesterase; pfam04185 331271009834 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271009835 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271009836 galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288 331271009837 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 331271009838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271009839 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 331271009840 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 331271009841 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 331271009842 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 331271009843 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 331271009844 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331271009845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271009846 ligand binding site [chemical binding]; other site 331271009847 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 331271009848 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 331271009849 trimer interface [polypeptide binding]; other site 331271009850 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 331271009851 YadA-like C-terminal region; Region: YadA; pfam03895 331271009852 Helix-turn-helix domain; Region: HTH_36; pfam13730 331271009853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271009854 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331271009855 Walker A motif; other site 331271009856 ATP binding site [chemical binding]; other site 331271009857 Walker B motif; other site 331271009858 arginine finger; other site 331271009859 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271009860 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271009861 non-specific DNA binding site [nucleotide binding]; other site 331271009862 salt bridge; other site 331271009863 sequence-specific DNA binding site [nucleotide binding]; other site 331271009864 head completion protein; Provisional; Region: 4; PHA02552 331271009865 Integrase core domain; Region: rve; pfam00665 331271009866 Bacterial TniB protein; Region: TniB; pfam05621 331271009867 TniQ; Region: TniQ; pfam06527 331271009868 TniQ; Region: TniQ; pfam06527 331271009869 H-NS histone family; Region: Histone_HNS; pfam00816 331271009870 Seripauperin and TIP1 family; Region: SRP1_TIP1; pfam00660 331271009871 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 331271009872 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 331271009873 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 331271009874 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 331271009875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271009876 active site 331271009877 FRG domain; Region: FRG; pfam08867 331271009878 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271009879 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271009880 conserved cys residue [active] 331271009881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271009882 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271009883 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 331271009884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271009885 NAD(P) binding site [chemical binding]; other site 331271009886 active site 331271009887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009888 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271009889 putative substrate translocation pore; other site 331271009890 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 331271009891 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271009892 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 331271009893 conserved cys residue [active] 331271009894 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271009895 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271009896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271009897 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 331271009898 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 331271009899 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 331271009900 dimer interface [polypeptide binding]; other site 331271009901 active site 331271009902 heme binding site [chemical binding]; other site 331271009903 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 331271009904 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271009905 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271009906 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271009907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271009908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271009910 dimerization interface [polypeptide binding]; other site 331271009911 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271009912 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271009913 ligand binding site [chemical binding]; other site 331271009914 flexible hinge region; other site 331271009915 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 331271009916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 331271009917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271009918 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271009919 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271009920 catalytic loop [active] 331271009921 iron binding site [ion binding]; other site 331271009922 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271009923 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271009924 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271009925 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271009926 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271009927 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271009928 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271009929 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 331271009930 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271009931 BON domain; Region: BON; pfam04972 331271009932 transcriptional regulator; Provisional; Region: PRK10632 331271009933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271009934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271009935 dimerization interface [polypeptide binding]; other site 331271009936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271009937 Response regulator receiver domain; Region: Response_reg; pfam00072 331271009938 active site 331271009939 phosphorylation site [posttranslational modification] 331271009940 intermolecular recognition site; other site 331271009941 dimerization interface [polypeptide binding]; other site 331271009942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271009943 PAS domain; Region: PAS_9; pfam13426 331271009944 putative active site [active] 331271009945 heme pocket [chemical binding]; other site 331271009946 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271009947 PAS fold; Region: PAS_3; pfam08447 331271009948 putative active site [active] 331271009949 heme pocket [chemical binding]; other site 331271009950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271009951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271009952 dimer interface [polypeptide binding]; other site 331271009953 phosphorylation site [posttranslational modification] 331271009954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271009955 ATP binding site [chemical binding]; other site 331271009956 Mg2+ binding site [ion binding]; other site 331271009957 G-X-G motif; other site 331271009958 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 331271009959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271009960 active site 331271009961 phosphorylation site [posttranslational modification] 331271009962 intermolecular recognition site; other site 331271009963 dimerization interface [polypeptide binding]; other site 331271009964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271009965 DNA binding residues [nucleotide binding] 331271009966 dimerization interface [polypeptide binding]; other site 331271009967 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271009968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271009969 putative substrate translocation pore; other site 331271009970 mercuric reductase; Validated; Region: PRK06370 331271009971 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271009972 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271009973 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331271009974 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271009975 Family description; Region: UvrD_C_2; pfam13538 331271009976 HEPN domain; Region: HEPN; cl00824 331271009977 Domain of unknown function (DUF955); Region: DUF955; cl01076 331271009978 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271009979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271009980 non-specific DNA binding site [nucleotide binding]; other site 331271009981 salt bridge; other site 331271009982 sequence-specific DNA binding site [nucleotide binding]; other site 331271009983 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 331271009984 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 331271009985 Predicted flavoprotein [General function prediction only]; Region: COG0431 331271009986 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271009987 NIPSNAP; Region: NIPSNAP; pfam07978 331271009988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271009989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271009990 Coenzyme A binding pocket [chemical binding]; other site 331271009991 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 331271009992 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 331271009993 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 331271009994 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 331271009995 Walker A/P-loop; other site 331271009996 ATP binding site [chemical binding]; other site 331271009997 Q-loop/lid; other site 331271009998 ABC transporter signature motif; other site 331271009999 Walker B; other site 331271010000 D-loop; other site 331271010001 H-loop/switch region; other site 331271010002 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 331271010003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271010004 dimer interface [polypeptide binding]; other site 331271010005 conserved gate region; other site 331271010006 putative PBP binding loops; other site 331271010007 ABC-ATPase subunit interface; other site 331271010008 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271010009 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 331271010010 conserved cys residue [active] 331271010011 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 331271010012 metal binding site [ion binding]; metal-binding site 331271010013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010014 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 331271010015 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 331271010016 Predicted membrane protein [Function unknown]; Region: COG2860 331271010017 UPF0126 domain; Region: UPF0126; pfam03458 331271010018 Predicted membrane protein [Function unknown]; Region: COG4125 331271010019 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 331271010020 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 331271010021 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271010022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010023 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271010024 dimerization interface [polypeptide binding]; other site 331271010025 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 331271010026 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271010027 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271010028 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271010029 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 331271010030 putative NAD(P) binding site [chemical binding]; other site 331271010031 active site 331271010032 putative substrate binding site [chemical binding]; other site 331271010033 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 331271010034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010035 D-galactonate transporter; Region: 2A0114; TIGR00893 331271010036 putative substrate translocation pore; other site 331271010037 putative aldolase; Validated; Region: PRK08130 331271010038 intersubunit interface [polypeptide binding]; other site 331271010039 active site 331271010040 Zn2+ binding site [ion binding]; other site 331271010041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 331271010042 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 331271010043 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271010044 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271010045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271010046 DNA-binding site [nucleotide binding]; DNA binding site 331271010047 FCD domain; Region: FCD; pfam07729 331271010048 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271010049 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 331271010050 conserved cys residue [active] 331271010051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010052 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 331271010053 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 331271010054 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 331271010055 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 331271010056 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271010057 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 331271010058 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 331271010059 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 331271010060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271010061 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 331271010062 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 331271010063 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 331271010064 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 331271010065 active site 331271010066 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 331271010067 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271010068 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271010069 catalytic residue [active] 331271010070 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 331271010071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271010072 ABC-ATPase subunit interface; other site 331271010073 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 331271010074 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 331271010075 Walker A/P-loop; other site 331271010076 ATP binding site [chemical binding]; other site 331271010077 Q-loop/lid; other site 331271010078 ABC transporter signature motif; other site 331271010079 Walker B; other site 331271010080 D-loop; other site 331271010081 H-loop/switch region; other site 331271010082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271010083 ABC-ATPase subunit interface; other site 331271010084 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 331271010085 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 331271010086 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 331271010087 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 331271010088 putative ligand binding site [chemical binding]; other site 331271010089 NAD binding site [chemical binding]; other site 331271010090 catalytic site [active] 331271010091 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 331271010092 nudix motif; other site 331271010093 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 331271010094 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271010095 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 331271010096 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 331271010097 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331271010098 FtsX-like permease family; Region: FtsX; pfam02687 331271010099 Probable transposase; Region: OrfB_IS605; pfam01385 331271010100 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271010101 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271010102 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 331271010103 MG2 domain; Region: A2M_N; pfam01835 331271010104 Alpha-2-macroglobulin family; Region: A2M; pfam00207 331271010105 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 331271010106 surface patch; other site 331271010107 thioester region; other site 331271010108 specificity defining residues; other site 331271010109 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 331271010110 Transglycosylase; Region: Transgly; pfam00912 331271010111 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331271010112 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 331271010113 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271010114 dimer interface [polypeptide binding]; other site 331271010115 putative CheW interface [polypeptide binding]; other site 331271010116 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271010117 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271010118 trimer interface [polypeptide binding]; other site 331271010119 eyelet of channel; other site 331271010120 acetyl-CoA synthetase; Provisional; Region: PRK00174 331271010121 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 331271010122 active site 331271010123 CoA binding site [chemical binding]; other site 331271010124 acyl-activating enzyme (AAE) consensus motif; other site 331271010125 AMP binding site [chemical binding]; other site 331271010126 acetate binding site [chemical binding]; other site 331271010127 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 331271010128 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331271010129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271010130 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331271010131 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271010132 DNA binding residues [nucleotide binding] 331271010133 High potential iron-sulfur protein; Region: HIPIP; pfam01355 331271010134 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 331271010135 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271010136 membrane-bound complex binding site; other site 331271010137 hinge residues; other site 331271010138 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 331271010139 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 331271010140 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 331271010141 dimer interface [polypeptide binding]; other site 331271010142 Trp docking motif [polypeptide binding]; other site 331271010143 active site 331271010144 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 331271010145 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271010146 N-terminal plug; other site 331271010147 ligand-binding site [chemical binding]; other site 331271010148 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 331271010149 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 331271010150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271010151 Walker A motif; other site 331271010152 ATP binding site [chemical binding]; other site 331271010153 Walker B motif; other site 331271010154 arginine finger; other site 331271010155 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271010156 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 331271010157 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 331271010158 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 331271010159 coenzyme PQQ biosynthesis protein PqqD; Region: PQQ_PqqD; TIGR03859 331271010160 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 331271010161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271010162 FeS/SAM binding site; other site 331271010163 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 331271010164 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 331271010165 Predicted esterase [General function prediction only]; Region: COG0627 331271010166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 331271010167 Lipase (class 2); Region: Lipase_2; pfam01674 331271010168 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 331271010169 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271010170 catalytic site [active] 331271010171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 331271010172 PAS fold; Region: PAS_4; pfam08448 331271010173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271010174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271010175 dimer interface [polypeptide binding]; other site 331271010176 phosphorylation site [posttranslational modification] 331271010177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271010178 ATP binding site [chemical binding]; other site 331271010179 G-X-G motif; other site 331271010180 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331271010181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271010182 active site 331271010183 phosphorylation site [posttranslational modification] 331271010184 intermolecular recognition site; other site 331271010185 dimerization interface [polypeptide binding]; other site 331271010186 benzoate transport; Region: 2A0115; TIGR00895 331271010187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010188 putative substrate translocation pore; other site 331271010189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010190 ABC-2 type transporter; Region: ABC2_membrane; cl17235 331271010191 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 331271010192 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 331271010193 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 331271010194 Walker A/P-loop; other site 331271010195 ATP binding site [chemical binding]; other site 331271010196 Q-loop/lid; other site 331271010197 ABC transporter signature motif; other site 331271010198 Walker B; other site 331271010199 D-loop; other site 331271010200 H-loop/switch region; other site 331271010201 Cupin domain; Region: Cupin_2; pfam07883 331271010202 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 331271010203 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 331271010204 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 331271010205 choline dehydrogenase; Validated; Region: PRK02106 331271010206 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271010207 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 331271010208 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 331271010209 tetrameric interface [polypeptide binding]; other site 331271010210 NAD binding site [chemical binding]; other site 331271010211 catalytic residues [active] 331271010212 transcriptional regulator BetI; Validated; Region: PRK00767 331271010213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271010214 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 331271010215 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271010216 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 331271010217 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 331271010218 active site 331271010219 TDP-binding site; other site 331271010220 acceptor substrate-binding pocket; other site 331271010221 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271010222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010223 putative substrate translocation pore; other site 331271010224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010225 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 331271010226 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 331271010227 Ligand binding site; other site 331271010228 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271010229 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 331271010230 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271010231 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 331271010232 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 331271010233 NAD binding site [chemical binding]; other site 331271010234 catalytic Zn binding site [ion binding]; other site 331271010235 structural Zn binding site [ion binding]; other site 331271010236 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 331271010237 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271010238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271010239 DNA-binding site [nucleotide binding]; DNA binding site 331271010240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271010241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271010242 homodimer interface [polypeptide binding]; other site 331271010243 catalytic residue [active] 331271010244 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 331271010245 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 331271010246 sugar binding site [chemical binding]; other site 331271010247 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271010248 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 331271010249 conserved cys residue [active] 331271010250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010251 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 331271010252 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 331271010253 dimer interface [polypeptide binding]; other site 331271010254 active site 331271010255 glycine-pyridoxal phosphate binding site [chemical binding]; other site 331271010256 folate binding site [chemical binding]; other site 331271010257 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 331271010258 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 331271010259 active site 331271010260 dimer interface [polypeptide binding]; other site 331271010261 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 331271010262 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 331271010263 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 331271010264 putative active site [active] 331271010265 putative FMN binding site [chemical binding]; other site 331271010266 putative substrate binding site [chemical binding]; other site 331271010267 putative catalytic residue [active] 331271010268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271010269 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 331271010270 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331271010271 4Fe-4S binding domain; Region: Fer4; cl02805 331271010272 Cysteine-rich domain; Region: CCG; pfam02754 331271010273 Cysteine-rich domain; Region: CCG; pfam02754 331271010274 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 331271010275 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 331271010276 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 331271010277 Electron transfer flavoprotein domain; Region: ETF; pfam01012 331271010278 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 331271010279 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 331271010280 [2Fe-2S] cluster binding site [ion binding]; other site 331271010281 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 331271010282 putative alpha subunit interface [polypeptide binding]; other site 331271010283 putative active site [active] 331271010284 putative substrate binding site [chemical binding]; other site 331271010285 Fe binding site [ion binding]; other site 331271010286 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 331271010287 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 331271010288 FAD binding pocket [chemical binding]; other site 331271010289 FAD binding motif [chemical binding]; other site 331271010290 phosphate binding motif [ion binding]; other site 331271010291 beta-alpha-beta structure motif; other site 331271010292 NAD binding pocket [chemical binding]; other site 331271010293 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 331271010294 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271010295 catalytic loop [active] 331271010296 iron binding site [ion binding]; other site 331271010297 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 331271010298 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 331271010299 Amino acid permease; Region: AA_permease_2; pfam13520 331271010300 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 331271010301 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 331271010302 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 331271010303 putative active site [active] 331271010304 putative substrate binding site [chemical binding]; other site 331271010305 putative cosubstrate binding site; other site 331271010306 catalytic site [active] 331271010307 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 331271010308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010309 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271010310 dimerization interface [polypeptide binding]; other site 331271010311 substrate binding pocket [chemical binding]; other site 331271010312 choline-sulfatase; Region: chol_sulfatase; TIGR03417 331271010313 Sulfatase; Region: Sulfatase; cl17466 331271010314 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 331271010315 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 331271010316 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 331271010317 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271010318 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271010319 trimer interface [polypeptide binding]; other site 331271010320 eyelet of channel; other site 331271010321 H+ Antiporter protein; Region: 2A0121; TIGR00900 331271010322 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 331271010323 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 331271010324 Peptidase family M28; Region: Peptidase_M28; pfam04389 331271010325 active site 331271010326 metal binding site [ion binding]; metal-binding site 331271010327 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 331271010328 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 331271010329 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 331271010330 Zn binding site [ion binding]; other site 331271010331 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271010332 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 331271010333 conserved cys residue [active] 331271010334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010335 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271010336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010337 methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658 331271010338 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 331271010339 Methylamine utilisation protein MauE; Region: MauE; pfam07291 331271010340 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 331271010341 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271010342 Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812 331271010343 Cytochrome c; Region: Cytochrom_C; pfam00034 331271010344 Cytochrome c; Region: Cytochrom_C; pfam00034 331271010345 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 331271010346 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271010347 NAD(P) binding site [chemical binding]; other site 331271010348 catalytic residues [active] 331271010349 Protein of unknown function, DUF606; Region: DUF606; pfam04657 331271010350 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 331271010351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010352 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 331271010353 dimerization interface [polypeptide binding]; other site 331271010354 substrate binding pocket [chemical binding]; other site 331271010355 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 331271010356 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 331271010357 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 331271010358 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 331271010359 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271010360 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271010361 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 331271010362 active site 331271010363 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271010364 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 331271010365 Protein of unknown function (DUF971); Region: DUF971; cl01414 331271010366 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 331271010367 substrate binding pocket [chemical binding]; other site 331271010368 active site 331271010369 iron coordination sites [ion binding]; other site 331271010370 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271010371 short chain dehydrogenase; Provisional; Region: PRK06197 331271010372 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 331271010373 putative NAD(P) binding site [chemical binding]; other site 331271010374 active site 331271010375 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 331271010376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331271010377 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 331271010378 NAD binding site [chemical binding]; other site 331271010379 homotetramer interface [polypeptide binding]; other site 331271010380 homodimer interface [polypeptide binding]; other site 331271010381 active site 331271010382 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331271010383 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271010384 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 331271010385 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 331271010386 putative active site pocket [active] 331271010387 metal binding site [ion binding]; metal-binding site 331271010388 short chain dehydrogenase; Provisional; Region: PRK08628 331271010389 classical (c) SDRs; Region: SDR_c; cd05233 331271010390 NAD(P) binding site [chemical binding]; other site 331271010391 active site 331271010392 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271010393 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271010394 Walker A/P-loop; other site 331271010395 ATP binding site [chemical binding]; other site 331271010396 Q-loop/lid; other site 331271010397 ABC transporter signature motif; other site 331271010398 Walker B; other site 331271010399 D-loop; other site 331271010400 H-loop/switch region; other site 331271010401 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271010402 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271010403 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271010404 TM-ABC transporter signature motif; other site 331271010405 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 331271010406 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271010407 putative ligand binding site [chemical binding]; other site 331271010408 Amidohydrolase; Region: Amidohydro_2; pfam04909 331271010409 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271010410 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271010411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271010412 DNA-binding site [nucleotide binding]; DNA binding site 331271010413 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 331271010414 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 331271010415 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 331271010416 phosphate binding site [ion binding]; other site 331271010417 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271010418 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271010419 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271010420 amidase; Provisional; Region: PRK09201 331271010421 Amidase; Region: Amidase; cl11426 331271010422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271010424 putative substrate translocation pore; other site 331271010425 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 331271010426 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271010427 active site 331271010428 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271010429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271010430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010431 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 331271010432 putative dimerization interface [polypeptide binding]; other site 331271010433 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 331271010434 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 331271010435 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271010436 metal binding site [ion binding]; metal-binding site 331271010437 active site 331271010438 I-site; other site 331271010439 putative outer membrane lipoprotein; Provisional; Region: PRK09967 331271010440 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271010441 ligand binding site [chemical binding]; other site 331271010442 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 331271010443 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 331271010444 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 331271010445 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 331271010446 PAAR motif; Region: PAAR_motif; pfam05488 331271010447 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 331271010448 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 331271010449 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 331271010450 RHS Repeat; Region: RHS_repeat; cl11982 331271010451 RHS Repeat; Region: RHS_repeat; cl11982 331271010452 RHS Repeat; Region: RHS_repeat; pfam05593 331271010453 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 331271010454 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 331271010455 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 331271010456 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271010457 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271010458 dimerization interface [polypeptide binding]; other site 331271010459 ligand binding site [chemical binding]; other site 331271010460 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271010461 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271010462 TM-ABC transporter signature motif; other site 331271010463 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 331271010464 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 331271010465 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271010466 TM-ABC transporter signature motif; other site 331271010467 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 331271010468 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271010469 Walker A/P-loop; other site 331271010470 ATP binding site [chemical binding]; other site 331271010471 Q-loop/lid; other site 331271010472 ABC transporter signature motif; other site 331271010473 Walker B; other site 331271010474 D-loop; other site 331271010475 H-loop/switch region; other site 331271010476 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331271010477 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271010478 Walker A/P-loop; other site 331271010479 ATP binding site [chemical binding]; other site 331271010480 Q-loop/lid; other site 331271010481 ABC transporter signature motif; other site 331271010482 Walker B; other site 331271010483 D-loop; other site 331271010484 H-loop/switch region; other site 331271010485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271010486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010487 LysR substrate binding domain; Region: LysR_substrate; pfam03466 331271010488 dimerization interface [polypeptide binding]; other site 331271010489 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 331271010490 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331271010491 EamA-like transporter family; Region: EamA; pfam00892 331271010492 EamA-like transporter family; Region: EamA; pfam00892 331271010493 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271010494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 331271010495 dimer interface [polypeptide binding]; other site 331271010496 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 331271010497 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271010498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010499 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271010500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010501 Cupin; Region: Cupin_6; pfam12852 331271010502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010503 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271010504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010505 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271010506 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 331271010507 NADP binding site [chemical binding]; other site 331271010508 active site 331271010509 steroid binding site; other site 331271010510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271010511 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 331271010512 inhibitor-cofactor binding pocket; inhibition site 331271010513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271010514 catalytic residue [active] 331271010515 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 331271010516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010517 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 331271010518 putative dimerization interface [polypeptide binding]; other site 331271010519 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 331271010520 chorismate binding enzyme; Region: Chorismate_bind; cl10555 331271010521 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 331271010522 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 331271010523 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 331271010524 nucleophilic elbow; other site 331271010525 catalytic triad; other site 331271010526 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 331271010527 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 331271010528 acyl-activating enzyme (AAE) consensus motif; other site 331271010529 active site 331271010530 AMP binding site [chemical binding]; other site 331271010531 substrate binding site [chemical binding]; other site 331271010532 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271010533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010534 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 331271010535 Condensation domain; Region: Condensation; pfam00668 331271010536 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 331271010537 Nonribosomal peptide synthase; Region: NRPS; pfam08415 331271010538 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 331271010539 acyl-activating enzyme (AAE) consensus motif; other site 331271010540 AMP binding site [chemical binding]; other site 331271010541 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271010542 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271010543 Condensation domain; Region: Condensation; pfam00668 331271010544 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 331271010545 Nonribosomal peptide synthase; Region: NRPS; pfam08415 331271010546 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 331271010547 acyl-activating enzyme (AAE) consensus motif; other site 331271010548 AMP binding site [chemical binding]; other site 331271010549 Methyltransferase domain; Region: Methyltransf_12; pfam08242 331271010550 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271010551 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271010552 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 331271010553 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 331271010554 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331271010555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271010556 Walker A/P-loop; other site 331271010557 ATP binding site [chemical binding]; other site 331271010558 Q-loop/lid; other site 331271010559 ABC transporter signature motif; other site 331271010560 Walker B; other site 331271010561 D-loop; other site 331271010562 H-loop/switch region; other site 331271010563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331271010564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271010565 Walker A/P-loop; other site 331271010566 ATP binding site [chemical binding]; other site 331271010567 Q-loop/lid; other site 331271010568 ABC transporter signature motif; other site 331271010569 Walker B; other site 331271010570 D-loop; other site 331271010571 H-loop/switch region; other site 331271010572 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 331271010573 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271010574 N-terminal plug; other site 331271010575 ligand-binding site [chemical binding]; other site 331271010576 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 331271010577 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 331271010578 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 331271010579 muropeptide transporter; Validated; Region: ampG; cl17669 331271010580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271010582 putative substrate translocation pore; other site 331271010583 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 331271010584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010585 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 331271010586 putative dimerization interface [polypeptide binding]; other site 331271010587 putative substrate binding pocket [chemical binding]; other site 331271010588 Leucine rich repeat; Region: LRR_8; pfam13855 331271010589 Protein kinase; unclassified specificity; Region: STYKc; smart00221 331271010590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 331271010591 active site 331271010592 ATP binding site [chemical binding]; other site 331271010593 substrate binding site [chemical binding]; other site 331271010594 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271010595 Protein of unknown function (DUF461); Region: DUF461; pfam04314 331271010596 CopC domain; Region: CopC; pfam04234 331271010597 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 331271010598 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 331271010599 putative hydrophobic ligand binding site [chemical binding]; other site 331271010600 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271010601 catalytic loop [active] 331271010602 iron binding site [ion binding]; other site 331271010603 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 331271010604 GAF domain; Region: GAF; pfam01590 331271010605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271010606 Walker A motif; other site 331271010607 ATP binding site [chemical binding]; other site 331271010608 Walker B motif; other site 331271010609 arginine finger; other site 331271010610 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271010611 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 331271010612 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 331271010613 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 331271010614 TPR repeat; Region: TPR_11; pfam13414 331271010615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271010616 binding surface 331271010617 TPR motif; other site 331271010618 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 331271010619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271010620 binding surface 331271010621 TPR motif; other site 331271010622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271010623 TPR motif; other site 331271010624 binding surface 331271010625 TPR repeat; Region: TPR_11; pfam13414 331271010626 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 331271010627 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 331271010628 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 331271010629 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 331271010630 short chain dehydrogenase; Validated; Region: PRK05855 331271010631 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271010632 classical (c) SDRs; Region: SDR_c; cd05233 331271010633 NAD(P) binding site [chemical binding]; other site 331271010634 active site 331271010635 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 331271010636 active site 331271010637 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 331271010638 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331271010639 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 331271010640 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 331271010641 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 331271010642 active site residues [active] 331271010643 dimer interface [polypeptide binding]; other site 331271010644 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 331271010645 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271010646 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271010647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010648 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271010649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271010650 active site 331271010651 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 331271010652 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 331271010653 active site 331271010654 acyl-activating enzyme (AAE) consensus motif; other site 331271010655 putative CoA binding site [chemical binding]; other site 331271010656 AMP binding site [chemical binding]; other site 331271010657 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 331271010658 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 331271010659 tetrameric interface [polypeptide binding]; other site 331271010660 NAD binding site [chemical binding]; other site 331271010661 catalytic residues [active] 331271010662 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271010663 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 331271010664 enoyl-CoA hydratase; Provisional; Region: PRK09076 331271010665 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271010666 substrate binding site [chemical binding]; other site 331271010667 oxyanion hole (OAH) forming residues; other site 331271010668 trimer interface [polypeptide binding]; other site 331271010669 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 331271010670 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271010671 substrate binding site [chemical binding]; other site 331271010672 oxyanion hole (OAH) forming residues; other site 331271010673 trimer interface [polypeptide binding]; other site 331271010674 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 331271010675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271010676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010677 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 331271010678 putative effector binding pocket; other site 331271010679 putative dimerization interface [polypeptide binding]; other site 331271010680 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271010681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010682 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271010683 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 331271010684 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331271010685 FtsX-like permease family; Region: FtsX; pfam02687 331271010686 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331271010687 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331271010688 Walker A/P-loop; other site 331271010689 ATP binding site [chemical binding]; other site 331271010690 Q-loop/lid; other site 331271010691 ABC transporter signature motif; other site 331271010692 Walker B; other site 331271010693 D-loop; other site 331271010694 H-loop/switch region; other site 331271010695 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271010696 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271010697 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271010698 HD domain; Region: HD_3; pfam13023 331271010699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271010700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271010701 non-specific DNA binding site [nucleotide binding]; other site 331271010702 salt bridge; other site 331271010703 sequence-specific DNA binding site [nucleotide binding]; other site 331271010704 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 331271010705 B1 nucleotide binding pocket [chemical binding]; other site 331271010706 B2 nucleotide binding pocket [chemical binding]; other site 331271010707 CAS motifs; other site 331271010708 active site 331271010709 Isochorismatase family; Region: Isochorismatase; pfam00857 331271010710 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 331271010711 catalytic triad [active] 331271010712 conserved cis-peptide bond; other site 331271010713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271010714 Cupin domain; Region: Cupin_2; cl17218 331271010715 Cytochrome c; Region: Cytochrom_C; cl11414 331271010716 Cytochrome c; Region: Cytochrom_C; pfam00034 331271010717 short chain dehydrogenase; Provisional; Region: PRK05854 331271010718 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 331271010719 putative NAD(P) binding site [chemical binding]; other site 331271010720 active site 331271010721 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 331271010722 glutaminase; Provisional; Region: PRK00971 331271010723 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 331271010724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271010725 active site 331271010726 phosphorylation site [posttranslational modification] 331271010727 intermolecular recognition site; other site 331271010728 dimerization interface [polypeptide binding]; other site 331271010729 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271010730 DNA binding site [nucleotide binding] 331271010731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271010732 dimer interface [polypeptide binding]; other site 331271010733 phosphorylation site [posttranslational modification] 331271010734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271010735 ATP binding site [chemical binding]; other site 331271010736 Mg2+ binding site [ion binding]; other site 331271010737 G-X-G motif; other site 331271010738 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 331271010739 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 331271010740 active site 331271010741 nucleophile elbow; other site 331271010742 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331271010743 Surface antigen; Region: Bac_surface_Ag; pfam01103 331271010744 rod shape-determining protein MreB; Provisional; Region: PRK13930 331271010745 MreB and similar proteins; Region: MreB_like; cd10225 331271010746 nucleotide binding site [chemical binding]; other site 331271010747 Mg binding site [ion binding]; other site 331271010748 putative protofilament interaction site [polypeptide binding]; other site 331271010749 RodZ interaction site [polypeptide binding]; other site 331271010750 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 331271010751 putative active site [active] 331271010752 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 331271010753 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 331271010754 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271010755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010756 The C-terminal substrate-binding domain of LysR-type trnascriptional regulator BlaA which involved in control of the beta-lactamase gene expression; contains the type 2 periplasmic binding fold; Region: PBP2_BlaA; cd08487 331271010757 putative dimerization interface [polypeptide binding]; other site 331271010758 putative substrate binding pocket [chemical binding]; other site 331271010759 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 331271010760 Protein of unknown function (DUF805); Region: DUF805; cl01224 331271010761 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 331271010762 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271010763 MarR family; Region: MarR_2; pfam12802 331271010764 sensor protein QseC; Provisional; Region: PRK10337 331271010765 HAMP domain; Region: HAMP; pfam00672 331271010766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271010767 dimer interface [polypeptide binding]; other site 331271010768 phosphorylation site [posttranslational modification] 331271010769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271010770 ATP binding site [chemical binding]; other site 331271010771 Mg2+ binding site [ion binding]; other site 331271010772 G-X-G motif; other site 331271010773 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 331271010774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271010775 active site 331271010776 phosphorylation site [posttranslational modification] 331271010777 intermolecular recognition site; other site 331271010778 dimerization interface [polypeptide binding]; other site 331271010779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271010780 DNA binding site [nucleotide binding] 331271010781 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 331271010782 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 331271010783 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271010784 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 331271010785 putative active site [active] 331271010786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271010787 Coenzyme A binding pocket [chemical binding]; other site 331271010788 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 331271010789 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 331271010790 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 331271010791 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 331271010792 tetramer interface [polypeptide binding]; other site 331271010793 active site 331271010794 Mg2+/Mn2+ binding site [ion binding]; other site 331271010795 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 331271010796 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 331271010797 Cytochrome P450; Region: p450; cl12078 331271010798 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 331271010799 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 331271010800 active site residue [active] 331271010801 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 331271010802 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271010803 conserved cys residue [active] 331271010804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010806 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 331271010807 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 331271010808 FMN binding site [chemical binding]; other site 331271010809 substrate binding site [chemical binding]; other site 331271010810 putative catalytic residue [active] 331271010811 hypothetical protein; Provisional; Region: PRK07907 331271010812 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 331271010813 metal binding site [ion binding]; metal-binding site 331271010814 putative dimer interface [polypeptide binding]; other site 331271010815 putative dehydrogenase; Provisional; Region: PRK10098 331271010816 TfoX N-terminal domain; Region: TfoX_N; pfam04993 331271010817 NnrU protein; Region: NnrU; pfam07298 331271010818 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 331271010819 Spore germination protein; Region: Spore_permease; cl17796 331271010820 hypothetical protein; Provisional; Region: PRK10621 331271010821 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331271010822 Protein of unknown function, DUF488; Region: DUF488; pfam04343 331271010823 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 331271010824 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271010825 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271010826 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271010827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271010828 non-specific DNA binding site [nucleotide binding]; other site 331271010829 salt bridge; other site 331271010830 sequence-specific DNA binding site [nucleotide binding]; other site 331271010831 Cupin domain; Region: Cupin_2; pfam07883 331271010832 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 331271010833 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 331271010834 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 331271010835 hypothetical protein; Provisional; Region: PRK07236 331271010836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271010837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271010839 dimerization interface [polypeptide binding]; other site 331271010840 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331271010841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271010842 Coenzyme A binding pocket [chemical binding]; other site 331271010843 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 331271010844 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 331271010845 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 331271010846 active site 331271010847 metal binding site [ion binding]; metal-binding site 331271010848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271010849 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 331271010850 spermidine synthase; Provisional; Region: PRK03612 331271010851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271010852 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 331271010853 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 331271010854 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 331271010855 Short C-terminal domain; Region: SHOCT; pfam09851 331271010856 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 331271010857 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 331271010858 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 331271010859 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331271010860 hydrophobic ligand binding site; other site 331271010861 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 331271010862 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331271010863 active site 331271010864 nucleotide binding site [chemical binding]; other site 331271010865 HIGH motif; other site 331271010866 KMSKS motif; other site 331271010867 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 331271010868 nudix motif; other site 331271010869 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 331271010870 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 331271010871 active site 331271010872 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271010873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271010874 DNA-binding site [nucleotide binding]; DNA binding site 331271010875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271010876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271010877 homodimer interface [polypeptide binding]; other site 331271010878 catalytic residue [active] 331271010879 EamA-like transporter family; Region: EamA; pfam00892 331271010880 diaminopimelate decarboxylase; Provisional; Region: PRK11165 331271010881 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 331271010882 active site 331271010883 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331271010884 substrate binding site [chemical binding]; other site 331271010885 catalytic residues [active] 331271010886 dimer interface [polypeptide binding]; other site 331271010887 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 331271010888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271010889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271010890 dimerization interface [polypeptide binding]; other site 331271010891 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 331271010892 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271010893 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 331271010894 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331271010895 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 331271010896 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 331271010897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331271010898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271010899 Coenzyme A binding pocket [chemical binding]; other site 331271010900 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 331271010901 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 331271010902 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 331271010903 gamma subunit interface [polypeptide binding]; other site 331271010904 epsilon subunit interface [polypeptide binding]; other site 331271010905 LBP interface [polypeptide binding]; other site 331271010906 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 331271010907 core domain interface [polypeptide binding]; other site 331271010908 delta subunit interface [polypeptide binding]; other site 331271010909 epsilon subunit interface [polypeptide binding]; other site 331271010910 phosphate acetyltransferase; Provisional; Region: PRK11890 331271010911 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 331271010912 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 331271010913 propionate/acetate kinase; Provisional; Region: PRK12379 331271010914 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 331271010915 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 331271010916 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 331271010917 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 331271010918 NAD binding site [chemical binding]; other site 331271010919 homotetramer interface [polypeptide binding]; other site 331271010920 homodimer interface [polypeptide binding]; other site 331271010921 substrate binding site [chemical binding]; other site 331271010922 active site 331271010923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 331271010924 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 331271010925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271010926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271010927 putative substrate translocation pore; other site 331271010928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271010929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271010930 Trehalase; Region: Trehalase; cl17346 331271010931 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 331271010932 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 331271010933 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 331271010934 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 331271010935 Autoinducer binding domain; Region: Autoind_bind; pfam03472 331271010936 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271010937 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271010938 DNA binding residues [nucleotide binding] 331271010939 dimerization interface [polypeptide binding]; other site 331271010940 Autoinducer binding domain; Region: Autoind_bind; pfam03472 331271010941 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 331271010942 DNA binding residues [nucleotide binding] 331271010943 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 331271010944 FHIPEP family; Region: FHIPEP; pfam00771 331271010945 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 331271010946 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 331271010947 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331271010948 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331271010949 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 331271010950 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 331271010951 FHA domain; Region: FHA; pfam00498 331271010952 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 331271010953 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 331271010954 YOP proteins translocation protein K (YscK); Region: YscK; pfam06578 331271010955 type III secretion system protein; Reviewed; Region: PRK06937 331271010956 Flagellar assembly protein FliH; Region: FliH; pfam02108 331271010957 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 331271010958 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 331271010959 Walker A motif/ATP binding site; other site 331271010960 Walker B motif; other site 331271010961 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 331271010962 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 331271010963 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 331271010964 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 331271010965 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 331271010966 active site 331271010967 dimer interface [polypeptide binding]; other site 331271010968 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 331271010969 Ligand Binding Site [chemical binding]; other site 331271010970 Molecular Tunnel; other site 331271010971 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 331271010972 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 331271010973 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 331271010974 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 331271010975 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271010976 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271010977 catalytic residue [active] 331271010978 type III secretion system protein YscR; Provisional; Region: PRK12797 331271010979 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 331271010980 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 331271010981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271010982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271010983 DNA binding site [nucleotide binding] 331271010984 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271010985 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271010986 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271010987 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271010988 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271010989 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271010990 catalytic loop [active] 331271010991 iron binding site [ion binding]; other site 331271010992 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271010993 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 331271010994 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271010995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271010996 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331271010997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271010998 Walker A motif; other site 331271010999 ATP binding site [chemical binding]; other site 331271011000 Walker B motif; other site 331271011001 arginine finger; other site 331271011002 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 331271011003 DNA-binding interface [nucleotide binding]; DNA binding site 331271011004 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271011005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 331271011006 active site 331271011007 phosphorylation site [posttranslational modification] 331271011008 intermolecular recognition site; other site 331271011009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271011010 DNA binding residues [nucleotide binding] 331271011011 dimerization interface [polypeptide binding]; other site 331271011012 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 331271011013 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 331271011014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271011015 dimer interface [polypeptide binding]; other site 331271011016 putative CheW interface [polypeptide binding]; other site 331271011017 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 331271011018 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 331271011019 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 331271011020 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271011021 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271011022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271011023 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 331271011024 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271011025 putative ligand binding site [chemical binding]; other site 331271011026 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271011027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271011028 Walker A/P-loop; other site 331271011029 ATP binding site [chemical binding]; other site 331271011030 Q-loop/lid; other site 331271011031 ABC transporter signature motif; other site 331271011032 Walker B; other site 331271011033 D-loop; other site 331271011034 H-loop/switch region; other site 331271011035 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271011036 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271011037 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271011038 TM-ABC transporter signature motif; other site 331271011039 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331271011040 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 331271011041 putative NAD(P) binding site [chemical binding]; other site 331271011042 catalytic Zn binding site [ion binding]; other site 331271011043 structural Zn binding site [ion binding]; other site 331271011044 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 331271011045 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 331271011046 N- and C-terminal domain interface [polypeptide binding]; other site 331271011047 putative active site [active] 331271011048 MgATP binding site [chemical binding]; other site 331271011049 catalytic site [active] 331271011050 metal binding site [ion binding]; metal-binding site 331271011051 putative xylulose binding site [chemical binding]; other site 331271011052 putative homodimer interface [polypeptide binding]; other site 331271011053 short chain dehydrogenase; Provisional; Region: PRK07060 331271011054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271011055 NAD(P) binding site [chemical binding]; other site 331271011056 active site 331271011057 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 331271011058 metal-binding site 331271011059 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 331271011060 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 331271011061 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 331271011062 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331271011063 Sel1-like repeats; Region: SEL1; smart00671 331271011064 Sel1-like repeats; Region: SEL1; smart00671 331271011065 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 331271011066 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271011067 N-terminal plug; other site 331271011068 ligand-binding site [chemical binding]; other site 331271011069 aspartate carbamoyltransferase; Provisional; Region: PRK11891 331271011070 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 331271011071 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 331271011072 Predicted small secreted protein [Function unknown]; Region: COG5510 331271011073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331271011074 EamA-like transporter family; Region: EamA; pfam00892 331271011075 EamA-like transporter family; Region: EamA; pfam00892 331271011076 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271011077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271011078 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271011079 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 331271011080 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 331271011081 classical (c) SDRs; Region: SDR_c; cd05233 331271011082 NAD(P) binding site [chemical binding]; other site 331271011083 active site 331271011084 Probable dihydrodipicolinate reductase; Region: PLN02775 331271011085 short chain dehydrogenase; Provisional; Region: PRK12828 331271011086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271011087 NAD(P) binding site [chemical binding]; other site 331271011088 active site 331271011089 DNA-binding response regulator CreB; Provisional; Region: PRK11083 331271011090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271011091 active site 331271011092 phosphorylation site [posttranslational modification] 331271011093 intermolecular recognition site; other site 331271011094 dimerization interface [polypeptide binding]; other site 331271011095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271011096 DNA binding site [nucleotide binding] 331271011097 sensory histidine kinase CreC; Provisional; Region: PRK11100 331271011098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271011099 dimerization interface [polypeptide binding]; other site 331271011100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271011101 dimer interface [polypeptide binding]; other site 331271011102 phosphorylation site [posttranslational modification] 331271011103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271011104 ATP binding site [chemical binding]; other site 331271011105 Mg2+ binding site [ion binding]; other site 331271011106 G-X-G motif; other site 331271011107 inner membrane protein; Provisional; Region: PRK11715 331271011108 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 331271011109 homotrimer interaction site [polypeptide binding]; other site 331271011110 putative active site [active] 331271011111 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 331271011112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011113 putative substrate translocation pore; other site 331271011114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271011117 dimerization interface [polypeptide binding]; other site 331271011118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271011119 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271011120 NAD(P) binding site [chemical binding]; other site 331271011121 active site 331271011122 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 331271011123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011124 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271011125 putative substrate translocation pore; other site 331271011126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271011129 dimerization interface [polypeptide binding]; other site 331271011130 classical (c) SDRs; Region: SDR_c; cd05233 331271011131 NAD(P) binding site [chemical binding]; other site 331271011132 active site 331271011133 Predicted metalloprotease [General function prediction only]; Region: COG2321 331271011134 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 331271011135 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271011136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271011137 DNA binding residues [nucleotide binding] 331271011138 dimerization interface [polypeptide binding]; other site 331271011139 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 331271011140 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271011141 NAD(P) binding site [chemical binding]; other site 331271011142 catalytic residues [active] 331271011143 hypothetical protein; Provisional; Region: PRK07481 331271011144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271011145 inhibitor-cofactor binding pocket; inhibition site 331271011146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271011147 catalytic residue [active] 331271011148 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 331271011149 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 331271011150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271011151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271011152 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011153 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011154 trimer interface [polypeptide binding]; other site 331271011155 eyelet of channel; other site 331271011156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 331271011157 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271011158 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 331271011159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271011160 dimer interface [polypeptide binding]; other site 331271011161 conserved gate region; other site 331271011162 putative PBP binding loops; other site 331271011163 ABC-ATPase subunit interface; other site 331271011164 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271011165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271011166 dimer interface [polypeptide binding]; other site 331271011167 conserved gate region; other site 331271011168 putative PBP binding loops; other site 331271011169 ABC-ATPase subunit interface; other site 331271011170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271011171 DNA binding site [nucleotide binding] 331271011172 domain linker motif; other site 331271011173 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 331271011174 putative dimerization interface [polypeptide binding]; other site 331271011175 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271011176 putative ligand binding site [chemical binding]; other site 331271011177 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 331271011178 active site 331271011179 catalytic site [active] 331271011180 putative metal binding site [ion binding]; other site 331271011181 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 331271011182 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271011183 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271011184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271011185 Coenzyme A binding pocket [chemical binding]; other site 331271011186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271011189 dimerization interface [polypeptide binding]; other site 331271011190 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331271011191 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 331271011192 metal binding site [ion binding]; metal-binding site 331271011193 putative dimer interface [polypeptide binding]; other site 331271011194 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011195 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011196 trimer interface [polypeptide binding]; other site 331271011197 eyelet of channel; other site 331271011198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011199 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271011200 putative substrate translocation pore; other site 331271011201 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271011202 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331271011203 FMN binding site [chemical binding]; other site 331271011204 active site 331271011205 substrate binding site [chemical binding]; other site 331271011206 catalytic residue [active] 331271011207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271011208 dimerization interface [polypeptide binding]; other site 331271011209 putative DNA binding site [nucleotide binding]; other site 331271011210 putative Zn2+ binding site [ion binding]; other site 331271011211 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331271011212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271011213 motif II; other site 331271011214 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 331271011215 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 331271011216 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 331271011217 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331271011218 active site 331271011219 metal binding site [ion binding]; metal-binding site 331271011220 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 331271011221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271011222 dimer interface [polypeptide binding]; other site 331271011223 conserved gate region; other site 331271011224 putative PBP binding loops; other site 331271011225 ABC-ATPase subunit interface; other site 331271011226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271011227 putative PBP binding loops; other site 331271011228 dimer interface [polypeptide binding]; other site 331271011229 ABC-ATPase subunit interface; other site 331271011230 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271011231 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271011232 Walker A/P-loop; other site 331271011233 ATP binding site [chemical binding]; other site 331271011234 Q-loop/lid; other site 331271011235 ABC transporter signature motif; other site 331271011236 Walker B; other site 331271011237 D-loop; other site 331271011238 H-loop/switch region; other site 331271011239 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 331271011240 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 331271011241 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271011242 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 331271011243 putative active site [active] 331271011244 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 331271011245 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 331271011246 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271011247 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 331271011248 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 331271011249 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331271011250 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271011251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271011252 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 331271011253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271011254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011256 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 331271011257 dimerization interface [polypeptide binding]; other site 331271011258 substrate binding pocket [chemical binding]; other site 331271011259 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 331271011260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271011261 NAD(P) binding site [chemical binding]; other site 331271011262 active site 331271011263 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 331271011264 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 331271011265 DNA binding residues [nucleotide binding] 331271011266 dimer interface [polypeptide binding]; other site 331271011267 [2Fe-2S] cluster binding site [ion binding]; other site 331271011268 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271011269 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271011270 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271011271 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271011272 MarR family; Region: MarR_2; cl17246 331271011273 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 331271011274 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 331271011275 C-terminal domain interface [polypeptide binding]; other site 331271011276 GSH binding site (G-site) [chemical binding]; other site 331271011277 dimer interface [polypeptide binding]; other site 331271011278 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 331271011279 N-terminal domain interface [polypeptide binding]; other site 331271011280 dimer interface [polypeptide binding]; other site 331271011281 substrate binding pocket (H-site) [chemical binding]; other site 331271011282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011283 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271011284 putative substrate translocation pore; other site 331271011285 Isochorismatase family; Region: Isochorismatase; pfam00857 331271011286 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 331271011287 catalytic triad [active] 331271011288 conserved cis-peptide bond; other site 331271011289 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 331271011290 Predicted transcriptional regulators [Transcription]; Region: COG1733 331271011291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271011292 dimerization interface [polypeptide binding]; other site 331271011293 putative DNA binding site [nucleotide binding]; other site 331271011294 putative Zn2+ binding site [ion binding]; other site 331271011295 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011296 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011297 trimer interface [polypeptide binding]; other site 331271011298 eyelet of channel; other site 331271011299 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 331271011300 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 331271011301 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271011302 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 331271011303 FOG: CBS domain [General function prediction only]; Region: COG0517 331271011304 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 331271011305 dimerization interface [polypeptide binding]; other site 331271011306 active site 331271011307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271011308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271011309 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 331271011310 active site 331271011311 metal binding site [ion binding]; metal-binding site 331271011312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271011313 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 331271011314 Autoinducer synthetase; Region: Autoind_synth; cl17404 331271011315 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 331271011316 Autoinducer binding domain; Region: Autoind_bind; pfam03472 331271011317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271011318 DNA binding residues [nucleotide binding] 331271011319 dimerization interface [polypeptide binding]; other site 331271011320 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 331271011321 MgtC family; Region: MgtC; pfam02308 331271011322 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331271011323 Fusaric acid resistance protein family; Region: FUSC; pfam04632 331271011324 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 331271011325 multidrug resistance protein MdtN; Provisional; Region: PRK10476 331271011326 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271011327 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271011328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011330 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 331271011331 putative dimerization interface [polypeptide binding]; other site 331271011332 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 331271011333 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331271011334 putative active site [active] 331271011335 putative metal binding site [ion binding]; other site 331271011336 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 331271011337 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271011338 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271011339 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271011340 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011341 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011342 trimer interface [polypeptide binding]; other site 331271011343 eyelet of channel; other site 331271011344 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 331271011345 [2Fe-2S] cluster binding site [ion binding]; other site 331271011346 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 331271011347 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 331271011348 [2Fe-2S] cluster binding site [ion binding]; other site 331271011349 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331271011350 hydrophobic ligand binding site; other site 331271011351 short chain dehydrogenase; Provisional; Region: PRK12939 331271011352 classical (c) SDRs; Region: SDR_c; cd05233 331271011353 NAD(P) binding site [chemical binding]; other site 331271011354 active site 331271011355 Cupin domain; Region: Cupin_2; pfam07883 331271011356 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271011357 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271011358 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271011359 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271011360 short chain dehydrogenase; Provisional; Region: PRK07062 331271011361 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 331271011362 putative NAD(P) binding site [chemical binding]; other site 331271011363 putative active site [active] 331271011364 hypothetical protein; Provisional; Region: PRK07064 331271011365 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271011366 PYR/PP interface [polypeptide binding]; other site 331271011367 dimer interface [polypeptide binding]; other site 331271011368 TPP binding site [chemical binding]; other site 331271011369 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271011370 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 331271011371 TPP-binding site [chemical binding]; other site 331271011372 L-aspartate dehydrogenase; Provisional; Region: PRK13303 331271011373 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 331271011374 Domain of unknown function DUF108; Region: DUF108; pfam01958 331271011375 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271011376 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 331271011377 NAD(P) binding site [chemical binding]; other site 331271011378 catalytic residues [active] 331271011379 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331271011380 active site 331271011381 metal binding site [ion binding]; metal-binding site 331271011382 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 331271011383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271011384 putative active site [active] 331271011385 putative metal binding site [ion binding]; other site 331271011386 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 331271011387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271011388 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271011389 benzoate transport; Region: 2A0115; TIGR00895 331271011390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011391 putative substrate translocation pore; other site 331271011392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271011394 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271011395 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 331271011396 trimer interface [polypeptide binding]; other site 331271011397 putative Zn binding site [ion binding]; other site 331271011398 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 331271011399 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 331271011400 substrate binding site [chemical binding]; other site 331271011401 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 331271011402 substrate binding site [chemical binding]; other site 331271011403 ligand binding site [chemical binding]; other site 331271011404 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 331271011405 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 331271011406 conserved cys residue [active] 331271011407 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271011408 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271011409 Ligand Binding Site [chemical binding]; other site 331271011410 amidase; Provisional; Region: PRK07486 331271011411 Amidase; Region: Amidase; pfam01425 331271011412 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 331271011413 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 331271011414 active site 331271011415 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 331271011416 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 331271011417 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 331271011418 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 331271011419 active site 1 [active] 331271011420 dimer interface [polypeptide binding]; other site 331271011421 hexamer interface [polypeptide binding]; other site 331271011422 active site 2 [active] 331271011423 aldolase II superfamily protein; Provisional; Region: PRK07044 331271011424 intersubunit interface [polypeptide binding]; other site 331271011425 active site 331271011426 Zn2+ binding site [ion binding]; other site 331271011427 Urea transporter; Region: UT; cl01829 331271011428 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271011429 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271011430 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 331271011431 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271011432 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271011433 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 331271011434 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 331271011435 short chain dehydrogenase; Provisional; Region: PRK07832 331271011436 classical (c) SDRs; Region: SDR_c; cd05233 331271011437 NAD(P) binding site [chemical binding]; other site 331271011438 active site 331271011439 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 331271011440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 331271011441 YhhN-like protein; Region: YhhN; pfam07947 331271011442 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 331271011443 oligomer interface [polypeptide binding]; other site 331271011444 putative active site [active] 331271011445 Mn binding site [ion binding]; other site 331271011446 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271011447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271011448 substrate binding pocket [chemical binding]; other site 331271011449 membrane-bound complex binding site; other site 331271011450 hinge residues; other site 331271011451 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 331271011452 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 331271011453 DNA binding residues [nucleotide binding] 331271011454 putative dimer interface [polypeptide binding]; other site 331271011455 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 331271011456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271011457 Coenzyme A binding pocket [chemical binding]; other site 331271011458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011460 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271011461 dimerization interface [polypeptide binding]; other site 331271011462 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 331271011463 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 331271011464 NADP binding site [chemical binding]; other site 331271011465 dimer interface [polypeptide binding]; other site 331271011466 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 331271011467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011468 putative substrate translocation pore; other site 331271011469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011470 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 331271011471 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 331271011472 dimer interface [polypeptide binding]; other site 331271011473 ligand binding site [chemical binding]; other site 331271011474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271011475 dimerization interface [polypeptide binding]; other site 331271011476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271011477 dimer interface [polypeptide binding]; other site 331271011478 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 331271011479 putative CheW interface [polypeptide binding]; other site 331271011480 Part of AAA domain; Region: AAA_19; pfam13245 331271011481 Family description; Region: UvrD_C_2; pfam13538 331271011482 BetR domain; Region: BetR; pfam08667 331271011483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271011484 active site 331271011485 phosphorylation site [posttranslational modification] 331271011486 intermolecular recognition site; other site 331271011487 dimerization interface [polypeptide binding]; other site 331271011488 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271011489 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271011490 Ion channel; Region: Ion_trans_2; pfam07885 331271011491 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 331271011492 TrkA-N domain; Region: TrkA_N; pfam02254 331271011493 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011494 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011495 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271011496 dimerization interface [polypeptide binding]; other site 331271011497 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271011498 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 331271011499 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271011500 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 331271011501 NAD(P) binding site [chemical binding]; other site 331271011502 catalytic residues [active] 331271011503 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 331271011504 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331271011505 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 331271011506 metal binding site [ion binding]; metal-binding site 331271011507 putative dimer interface [polypeptide binding]; other site 331271011508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271011510 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 331271011511 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271011512 substrate binding pocket [chemical binding]; other site 331271011513 membrane-bound complex binding site; other site 331271011514 hinge residues; other site 331271011515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011516 D-galactonate transporter; Region: 2A0114; TIGR00893 331271011517 putative substrate translocation pore; other site 331271011518 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 331271011519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011521 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 331271011522 putative dimerization interface [polypeptide binding]; other site 331271011523 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 331271011524 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271011525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271011526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271011527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271011528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271011529 active site 331271011530 catalytic tetrad [active] 331271011531 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271011532 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 331271011533 NADP binding site [chemical binding]; other site 331271011534 dimer interface [polypeptide binding]; other site 331271011535 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271011536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271011537 putative DNA binding site [nucleotide binding]; other site 331271011538 putative Zn2+ binding site [ion binding]; other site 331271011539 AsnC family; Region: AsnC_trans_reg; pfam01037 331271011540 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 331271011541 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 331271011542 homodimer interface [polypeptide binding]; other site 331271011543 substrate-cofactor binding pocket; other site 331271011544 catalytic residue [active] 331271011545 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 331271011546 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 331271011547 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 331271011548 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 331271011549 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 331271011550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271011551 motif II; other site 331271011552 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 331271011553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011554 putative substrate translocation pore; other site 331271011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011556 Response regulator receiver domain; Region: Response_reg; pfam00072 331271011557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271011558 active site 331271011559 phosphorylation site [posttranslational modification] 331271011560 intermolecular recognition site; other site 331271011561 dimerization interface [polypeptide binding]; other site 331271011562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271011563 DNA binding residues [nucleotide binding] 331271011564 dimerization interface [polypeptide binding]; other site 331271011565 Na binding site [ion binding]; other site 331271011566 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 331271011567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271011568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271011569 dimer interface [polypeptide binding]; other site 331271011570 phosphorylation site [posttranslational modification] 331271011571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271011572 ATP binding site [chemical binding]; other site 331271011573 Mg2+ binding site [ion binding]; other site 331271011574 G-X-G motif; other site 331271011575 Response regulator receiver domain; Region: Response_reg; pfam00072 331271011576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271011577 active site 331271011578 phosphorylation site [posttranslational modification] 331271011579 intermolecular recognition site; other site 331271011580 dimerization interface [polypeptide binding]; other site 331271011581 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 331271011582 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 331271011583 putative ligand binding site [chemical binding]; other site 331271011584 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271011585 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271011586 TM-ABC transporter signature motif; other site 331271011587 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331271011588 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271011589 TM-ABC transporter signature motif; other site 331271011590 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 331271011591 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271011592 Walker A/P-loop; other site 331271011593 ATP binding site [chemical binding]; other site 331271011594 Q-loop/lid; other site 331271011595 ABC transporter signature motif; other site 331271011596 Walker B; other site 331271011597 D-loop; other site 331271011598 H-loop/switch region; other site 331271011599 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 331271011600 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271011601 Walker A/P-loop; other site 331271011602 ATP binding site [chemical binding]; other site 331271011603 Q-loop/lid; other site 331271011604 ABC transporter signature motif; other site 331271011605 Walker B; other site 331271011606 D-loop; other site 331271011607 H-loop/switch region; other site 331271011608 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 331271011609 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 331271011610 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 331271011611 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 331271011612 multimer interface [polypeptide binding]; other site 331271011613 active site 331271011614 catalytic triad [active] 331271011615 dimer interface [polypeptide binding]; other site 331271011616 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011617 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011618 trimer interface [polypeptide binding]; other site 331271011619 eyelet of channel; other site 331271011620 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271011621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271011622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271011623 active site 331271011624 phosphorylation site [posttranslational modification] 331271011625 intermolecular recognition site; other site 331271011626 dimerization interface [polypeptide binding]; other site 331271011627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271011628 DNA binding site [nucleotide binding] 331271011629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271011630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271011631 dimerization interface [polypeptide binding]; other site 331271011632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271011633 ATP binding site [chemical binding]; other site 331271011634 Mg2+ binding site [ion binding]; other site 331271011635 G-X-G motif; other site 331271011636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271011637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 331271011638 active site 331271011639 phosphorylation site [posttranslational modification] 331271011640 intermolecular recognition site; other site 331271011641 dimerization interface [polypeptide binding]; other site 331271011642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271011643 DNA binding site [nucleotide binding] 331271011644 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271011645 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011646 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011647 trimer interface [polypeptide binding]; other site 331271011648 eyelet of channel; other site 331271011649 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271011650 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271011651 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271011652 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331271011653 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271011654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271011655 active site 331271011656 phosphorylation site [posttranslational modification] 331271011657 intermolecular recognition site; other site 331271011658 dimerization interface [polypeptide binding]; other site 331271011659 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271011660 DNA binding site [nucleotide binding] 331271011661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011663 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271011664 putative effector binding pocket; other site 331271011665 dimerization interface [polypeptide binding]; other site 331271011666 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 331271011667 classical (c) SDRs; Region: SDR_c; cd05233 331271011668 NAD(P) binding site [chemical binding]; other site 331271011669 active site 331271011670 Cytochrome c; Region: Cytochrom_C; pfam00034 331271011671 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271011672 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271011673 Cytochrome c; Region: Cytochrom_C; pfam00034 331271011674 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 331271011675 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 331271011676 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271011677 S-formylglutathione hydrolase; Region: PLN02442 331271011678 Putative esterase; Region: Esterase; pfam00756 331271011679 OpgC protein; Region: OpgC_C; pfam10129 331271011680 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011681 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011682 trimer interface [polypeptide binding]; other site 331271011683 eyelet of channel; other site 331271011684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011686 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271011687 putative effector binding pocket; other site 331271011688 putative dimerization interface [polypeptide binding]; other site 331271011689 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271011690 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271011691 active site 331271011692 catalytic tetrad [active] 331271011693 Predicted ester cyclase [General function prediction only]; Region: COG5485 331271011694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011696 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 331271011697 putative dimerization interface [polypeptide binding]; other site 331271011698 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331271011699 Peptidase family M23; Region: Peptidase_M23; pfam01551 331271011700 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 331271011701 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271011702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011703 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271011704 substrate binding pocket [chemical binding]; other site 331271011705 dimerization interface [polypeptide binding]; other site 331271011706 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 331271011707 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 331271011708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271011709 Walker A/P-loop; other site 331271011710 ATP binding site [chemical binding]; other site 331271011711 Q-loop/lid; other site 331271011712 ABC transporter signature motif; other site 331271011713 Walker B; other site 331271011714 D-loop; other site 331271011715 H-loop/switch region; other site 331271011716 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 331271011717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271011718 Walker A/P-loop; other site 331271011719 ATP binding site [chemical binding]; other site 331271011720 Q-loop/lid; other site 331271011721 ABC transporter signature motif; other site 331271011722 Walker B; other site 331271011723 D-loop; other site 331271011724 H-loop/switch region; other site 331271011725 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 331271011726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271011727 dimer interface [polypeptide binding]; other site 331271011728 conserved gate region; other site 331271011729 putative PBP binding loops; other site 331271011730 ABC-ATPase subunit interface; other site 331271011731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331271011732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271011733 dimer interface [polypeptide binding]; other site 331271011734 conserved gate region; other site 331271011735 putative PBP binding loops; other site 331271011736 ABC-ATPase subunit interface; other site 331271011737 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 331271011738 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 331271011739 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 331271011740 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 331271011741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271011742 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 331271011743 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 331271011744 Cupin; Region: Cupin_1; smart00835 331271011745 Cupin; Region: Cupin_1; smart00835 331271011746 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 331271011747 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 331271011748 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 331271011749 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 331271011750 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271011751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011752 putative substrate translocation pore; other site 331271011753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011756 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271011757 putative effector binding pocket; other site 331271011758 dimerization interface [polypeptide binding]; other site 331271011759 Fusaric acid resistance protein family; Region: FUSC; pfam04632 331271011760 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 331271011761 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 331271011762 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 331271011763 putative molybdopterin cofactor binding site [chemical binding]; other site 331271011764 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 331271011765 putative molybdopterin cofactor binding site; other site 331271011766 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271011767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271011768 DNA-binding site [nucleotide binding]; DNA binding site 331271011769 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271011770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271011771 homodimer interface [polypeptide binding]; other site 331271011772 catalytic residue [active] 331271011773 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331271011774 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271011775 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 331271011776 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 331271011777 Sulfate transporter family; Region: Sulfate_transp; pfam00916 331271011778 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 331271011779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271011782 dimerization interface [polypeptide binding]; other site 331271011783 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271011784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011785 putative substrate translocation pore; other site 331271011786 Isochorismatase family; Region: Isochorismatase; pfam00857 331271011787 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 331271011788 catalytic triad [active] 331271011789 conserved cis-peptide bond; other site 331271011790 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271011791 MarR family; Region: MarR; pfam01047 331271011792 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 331271011793 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 331271011794 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 331271011795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011796 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 331271011797 dimerization interface [polypeptide binding]; other site 331271011798 substrate binding pocket [chemical binding]; other site 331271011799 magnesium-transporting ATPase; Provisional; Region: PRK15122 331271011800 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 331271011801 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331271011802 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 331271011803 Soluble P-type ATPase [General function prediction only]; Region: COG4087 331271011804 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 331271011805 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 331271011806 active site 331271011807 catalytic triad [active] 331271011808 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 331271011809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271011810 substrate binding pocket [chemical binding]; other site 331271011811 membrane-bound complex binding site; other site 331271011812 hinge residues; other site 331271011813 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 331271011814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011815 putative substrate translocation pore; other site 331271011816 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 331271011817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271011818 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 331271011819 Transglycosylase; Region: Transgly; pfam00912 331271011820 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331271011821 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 331271011822 Bacterial Ig-like domain; Region: Big_5; pfam13205 331271011823 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 331271011824 MG2 domain; Region: A2M_N; pfam01835 331271011825 Alpha-2-macroglobulin family; Region: A2M; pfam00207 331271011826 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 331271011827 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 331271011828 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271011829 Cytochrome c; Region: Cytochrom_C; pfam00034 331271011830 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271011831 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271011832 Cytochrome c; Region: Cytochrom_C; pfam00034 331271011833 Predicted membrane protein [Function unknown]; Region: COG2259 331271011834 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271011835 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271011836 trimer interface [polypeptide binding]; other site 331271011837 eyelet of channel; other site 331271011838 Isochorismatase family; Region: Isochorismatase; pfam00857 331271011839 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 331271011840 catalytic triad [active] 331271011841 conserved cis-peptide bond; other site 331271011842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 331271011843 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271011844 putative substrate translocation pore; other site 331271011845 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331271011846 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 331271011847 metal binding site [ion binding]; metal-binding site 331271011848 putative dimer interface [polypeptide binding]; other site 331271011849 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 331271011850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271011852 dimerization interface [polypeptide binding]; other site 331271011853 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 331271011854 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 331271011855 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 331271011856 Cl- selectivity filter; other site 331271011857 Cl- binding residues [ion binding]; other site 331271011858 pore gating glutamate residue; other site 331271011859 dimer interface [polypeptide binding]; other site 331271011860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 331271011861 FOG: CBS domain [General function prediction only]; Region: COG0517 331271011862 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271011863 MarR family; Region: MarR_2; pfam12802 331271011864 MarR family; Region: MarR_2; cl17246 331271011865 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 331271011866 HPP family; Region: HPP; pfam04982 331271011867 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 331271011868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271011869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011870 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271011871 putative effector binding pocket; other site 331271011872 dimerization interface [polypeptide binding]; other site 331271011873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011874 D-galactonate transporter; Region: 2A0114; TIGR00893 331271011875 putative substrate translocation pore; other site 331271011876 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 331271011877 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 331271011878 putative ligand binding site [chemical binding]; other site 331271011879 NAD binding site [chemical binding]; other site 331271011880 catalytic site [active] 331271011881 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 331271011882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271011883 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271011884 dimerization interface [polypeptide binding]; other site 331271011885 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 331271011886 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 331271011887 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 331271011888 DctM-like transporters; Region: DctM; pfam06808 331271011889 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 331271011890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271011891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271011892 DNA binding site [nucleotide binding] 331271011893 domain linker motif; other site 331271011894 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 331271011895 putative dimerization interface [polypeptide binding]; other site 331271011896 putative ligand binding site [chemical binding]; other site 331271011897 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 331271011898 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 331271011899 putative ligand binding site [chemical binding]; other site 331271011900 putative NAD binding site [chemical binding]; other site 331271011901 catalytic site [active] 331271011902 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271011903 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271011904 active site 331271011905 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 331271011906 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 331271011907 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271011908 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271011909 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271011910 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 331271011911 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 331271011912 active site 331271011913 AMP binding site [chemical binding]; other site 331271011914 homodimer interface [polypeptide binding]; other site 331271011915 acyl-activating enzyme (AAE) consensus motif; other site 331271011916 CoA binding site [chemical binding]; other site 331271011917 enoyl-CoA hydratase; Provisional; Region: PRK05995 331271011918 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271011919 substrate binding site [chemical binding]; other site 331271011920 oxyanion hole (OAH) forming residues; other site 331271011921 trimer interface [polypeptide binding]; other site 331271011922 MarC family integral membrane protein; Region: MarC; cl00919 331271011923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271011924 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271011925 active site 331271011926 catalytic tetrad [active] 331271011927 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331271011928 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 331271011929 putative NAD(P) binding site [chemical binding]; other site 331271011930 catalytic Zn binding site [ion binding]; other site 331271011931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 331271011932 Coenzyme A binding pocket [chemical binding]; other site 331271011933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011934 putative substrate translocation pore; other site 331271011935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271011936 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 331271011937 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 331271011938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271011939 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271011940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271011941 Coenzyme A binding pocket [chemical binding]; other site 331271011942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271011943 DNA-binding site [nucleotide binding]; DNA binding site 331271011944 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271011945 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271011946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271011947 homodimer interface [polypeptide binding]; other site 331271011948 catalytic residue [active] 331271011949 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 331271011950 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 331271011951 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331271011952 protein binding site [polypeptide binding]; other site 331271011953 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331271011954 protein binding site [polypeptide binding]; other site 331271011955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011956 putative substrate translocation pore; other site 331271011957 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 331271011958 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331271011959 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271011960 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271011961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271011962 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 331271011963 putative uracil binding site [chemical binding]; other site 331271011964 putative active site [active] 331271011965 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 331271011966 NMT1-like family; Region: NMT1_2; pfam13379 331271011967 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 331271011968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271011969 active site 331271011970 phosphorylation site [posttranslational modification] 331271011971 intermolecular recognition site; other site 331271011972 dimerization interface [polypeptide binding]; other site 331271011973 ANTAR domain; Region: ANTAR; pfam03861 331271011974 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 331271011975 active site 331271011976 SAM binding site [chemical binding]; other site 331271011977 homodimer interface [polypeptide binding]; other site 331271011978 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 331271011979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271011980 putative substrate translocation pore; other site 331271011981 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 331271011982 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 331271011983 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 331271011984 [4Fe-4S] binding site [ion binding]; other site 331271011985 molybdopterin cofactor binding site; other site 331271011986 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 331271011987 molybdopterin cofactor binding site; other site 331271011988 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 331271011989 Flavodoxin; Region: Flavodoxin_1; pfam00258 331271011990 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 331271011991 FAD binding pocket [chemical binding]; other site 331271011992 FAD binding motif [chemical binding]; other site 331271011993 catalytic residues [active] 331271011994 NAD binding pocket [chemical binding]; other site 331271011995 phosphate binding motif [ion binding]; other site 331271011996 beta-alpha-beta structure motif; other site 331271011997 short chain dehydrogenase; Provisional; Region: PRK09291 331271011998 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271011999 NADP binding site [chemical binding]; other site 331271012000 active site 331271012001 steroid binding site; other site 331271012002 Domain of unknown function (DUF336); Region: DUF336; pfam03928 331271012003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271012004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012005 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 331271012006 putative effector binding pocket; other site 331271012007 putative dimerization interface [polypeptide binding]; other site 331271012008 Predicted integral membrane protein [Function unknown]; Region: COG0392 331271012009 Uncharacterized conserved protein [Function unknown]; Region: COG2898 331271012010 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 331271012011 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 331271012012 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 331271012013 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271012014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271012015 DNA-binding site [nucleotide binding]; DNA binding site 331271012016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271012017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271012018 homodimer interface [polypeptide binding]; other site 331271012019 catalytic residue [active] 331271012020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012021 D-galactonate transporter; Region: 2A0114; TIGR00893 331271012022 putative substrate translocation pore; other site 331271012023 mannonate dehydratase; Provisional; Region: PRK03906 331271012024 mannonate dehydratase; Region: uxuA; TIGR00695 331271012025 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271012026 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 331271012027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271012028 dimerization interface [polypeptide binding]; other site 331271012029 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271012030 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271012031 metal binding site [ion binding]; metal-binding site 331271012032 active site 331271012033 I-site; other site 331271012034 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271012035 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 331271012036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012037 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271012038 dimerization interface [polypeptide binding]; other site 331271012039 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271012040 aromatic amino acid exporter; Provisional; Region: PRK11689 331271012041 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 331271012042 active site 331271012043 metal binding site [ion binding]; metal-binding site 331271012044 RNA polymerase sigma factor; Reviewed; Region: PRK05602 331271012045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271012046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271012047 Heavy-metal resistance; Region: Metal_resist; pfam13801 331271012048 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 331271012049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 331271012050 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 331271012051 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 331271012052 Int/Topo IB signature motif; other site 331271012053 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 331271012054 putative transporter; Provisional; Region: PRK10504 331271012055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012056 putative substrate translocation pore; other site 331271012057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012058 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 331271012059 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 331271012060 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 331271012061 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331271012062 oligomeric interface; other site 331271012063 putative active site [active] 331271012064 homodimer interface [polypeptide binding]; other site 331271012065 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 331271012066 DNA-binding site [nucleotide binding]; DNA binding site 331271012067 RNA-binding motif; other site 331271012068 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 331271012069 rRNA binding site [nucleotide binding]; other site 331271012070 predicted 30S ribosome binding site; other site 331271012071 Phosphoesterase family; Region: Phosphoesterase; pfam04185 331271012072 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 331271012073 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 331271012074 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 331271012075 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271012076 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271012077 putative DNA binding site [nucleotide binding]; other site 331271012078 putative Zn2+ binding site [ion binding]; other site 331271012079 AsnC family; Region: AsnC_trans_reg; pfam01037 331271012080 LysE type translocator; Region: LysE; cl00565 331271012081 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 331271012082 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271012083 N-terminal plug; other site 331271012084 ligand-binding site [chemical binding]; other site 331271012085 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 331271012086 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 331271012087 tetramer interface [polypeptide binding]; other site 331271012088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271012089 catalytic residue [active] 331271012090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 331271012091 YheO-like PAS domain; Region: PAS_6; pfam08348 331271012092 HTH domain; Region: HTH_22; pfam13309 331271012093 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 331271012094 putative deacylase active site [active] 331271012095 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 331271012096 tetramer interface [polypeptide binding]; other site 331271012097 active site 331271012098 Mg2+/Mn2+ binding site [ion binding]; other site 331271012099 isocitrate lyase; Region: PLN02892 331271012100 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 331271012101 active site 331271012102 substrate-binding site [chemical binding]; other site 331271012103 metal-binding site [ion binding] 331271012104 GTP binding site [chemical binding]; other site 331271012105 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 331271012106 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 331271012107 FtsH Extracellular; Region: FtsH_ext; pfam06480 331271012108 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 331271012109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271012110 Walker A motif; other site 331271012111 ATP binding site [chemical binding]; other site 331271012112 Walker B motif; other site 331271012113 arginine finger; other site 331271012114 Peptidase family M41; Region: Peptidase_M41; pfam01434 331271012115 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 331271012116 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 331271012117 active site 331271012118 homotetramer interface [polypeptide binding]; other site 331271012119 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271012120 dimerization interface [polypeptide binding]; other site 331271012121 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271012122 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271012123 dimer interface [polypeptide binding]; other site 331271012124 putative CheW interface [polypeptide binding]; other site 331271012125 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 331271012126 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271012127 N-terminal plug; other site 331271012128 ligand-binding site [chemical binding]; other site 331271012129 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 331271012130 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 331271012131 NAD binding site [chemical binding]; other site 331271012132 substrate binding site [chemical binding]; other site 331271012133 catalytic Zn binding site [ion binding]; other site 331271012134 tetramer interface [polypeptide binding]; other site 331271012135 structural Zn binding site [ion binding]; other site 331271012136 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 331271012137 Asp-box motif; other site 331271012138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271012139 MarR family; Region: MarR; pfam01047 331271012140 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 331271012141 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271012142 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271012143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271012144 substrate binding pocket [chemical binding]; other site 331271012145 membrane-bound complex binding site; other site 331271012146 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 331271012147 active site 331271012148 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 331271012149 dimer interface [polypeptide binding]; other site 331271012150 non-prolyl cis peptide bond; other site 331271012151 insertion regions; other site 331271012152 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271012153 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271012154 substrate binding pocket [chemical binding]; other site 331271012155 membrane-bound complex binding site; other site 331271012156 hinge residues; other site 331271012157 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271012158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271012159 dimer interface [polypeptide binding]; other site 331271012160 conserved gate region; other site 331271012161 putative PBP binding loops; other site 331271012162 ABC-ATPase subunit interface; other site 331271012163 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 331271012164 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271012165 Walker A/P-loop; other site 331271012166 ATP binding site [chemical binding]; other site 331271012167 Q-loop/lid; other site 331271012168 ABC transporter signature motif; other site 331271012169 Walker B; other site 331271012170 D-loop; other site 331271012171 H-loop/switch region; other site 331271012172 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 331271012173 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 331271012174 active site 331271012175 non-prolyl cis peptide bond; other site 331271012176 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 331271012177 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 331271012178 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 331271012179 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271012180 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271012181 substrate binding pocket [chemical binding]; other site 331271012182 membrane-bound complex binding site; other site 331271012183 hinge residues; other site 331271012184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271012185 Coenzyme A binding pocket [chemical binding]; other site 331271012186 recombination associated protein; Reviewed; Region: rdgC; PRK00321 331271012187 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 331271012188 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 331271012189 putative active site [active] 331271012190 Zn binding site [ion binding]; other site 331271012191 PAS domain; Region: PAS; smart00091 331271012192 PAS fold; Region: PAS_7; pfam12860 331271012193 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271012194 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271012195 metal binding site [ion binding]; metal-binding site 331271012196 active site 331271012197 I-site; other site 331271012198 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271012199 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271012200 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271012201 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271012202 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271012203 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271012204 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271012205 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271012206 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271012207 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271012208 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 331271012209 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271012210 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331271012211 ligand binding site [chemical binding]; other site 331271012212 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271012213 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271012214 trimer interface [polypeptide binding]; other site 331271012215 eyelet of channel; other site 331271012216 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331271012217 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 331271012218 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 331271012219 active site 331271012220 nucleophile elbow; other site 331271012221 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271012222 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 331271012223 tetramerization interface [polypeptide binding]; other site 331271012224 NAD(P) binding site [chemical binding]; other site 331271012225 catalytic residues [active] 331271012226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271012227 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 331271012228 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271012229 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271012230 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271012231 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271012232 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271012233 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271012234 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271012235 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271012236 catalytic loop [active] 331271012237 iron binding site [ion binding]; other site 331271012238 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271012239 Uncharacterized conserved protein [Function unknown]; Region: COG1359 331271012240 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 331271012241 Prostaglandin dehydrogenases; Region: PGDH; cd05288 331271012242 NAD(P) binding site [chemical binding]; other site 331271012243 substrate binding site [chemical binding]; other site 331271012244 dimer interface [polypeptide binding]; other site 331271012245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271012246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271012247 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 331271012248 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271012249 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271012250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 331271012251 Cation efflux family; Region: Cation_efflux; cl00316 331271012252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271012253 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271012254 salt bridge; other site 331271012255 non-specific DNA binding site [nucleotide binding]; other site 331271012256 sequence-specific DNA binding site [nucleotide binding]; other site 331271012257 HipA N-terminal domain; Region: Couple_hipA; cl11853 331271012258 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 331271012259 HipA-like N-terminal domain; Region: HipA_N; pfam07805 331271012260 HipA-like C-terminal domain; Region: HipA_C; pfam07804 331271012261 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 331271012262 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 331271012263 dimer interface [polypeptide binding]; other site 331271012264 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 331271012265 active site 331271012266 Fe binding site [ion binding]; other site 331271012267 shikimate transporter; Provisional; Region: PRK09952 331271012268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012269 putative substrate translocation pore; other site 331271012270 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 331271012271 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 331271012272 putative active site [active] 331271012273 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 331271012274 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 331271012275 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 331271012276 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271012277 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 331271012278 DEAD_2; Region: DEAD_2; pfam06733 331271012279 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 331271012280 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 331271012281 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 331271012282 FOG: CBS domain [General function prediction only]; Region: COG0517 331271012283 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 331271012284 PRC-barrel domain; Region: PRC; pfam05239 331271012285 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 331271012286 BON domain; Region: BON; pfam04972 331271012287 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 331271012288 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271012289 putative active site [active] 331271012290 heme pocket [chemical binding]; other site 331271012291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271012292 dimer interface [polypeptide binding]; other site 331271012293 phosphorylation site [posttranslational modification] 331271012294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271012295 ATP binding site [chemical binding]; other site 331271012296 G-X-G motif; other site 331271012297 Response regulator receiver domain; Region: Response_reg; pfam00072 331271012298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271012299 active site 331271012300 phosphorylation site [posttranslational modification] 331271012301 intermolecular recognition site; other site 331271012302 dimerization interface [polypeptide binding]; other site 331271012303 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 331271012304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271012305 Walker A motif; other site 331271012306 ATP binding site [chemical binding]; other site 331271012307 Walker B motif; other site 331271012308 arginine finger; other site 331271012309 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271012310 Cache domain; Region: Cache_1; pfam02743 331271012311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271012312 dimerization interface [polypeptide binding]; other site 331271012313 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271012314 dimer interface [polypeptide binding]; other site 331271012315 putative CheW interface [polypeptide binding]; other site 331271012316 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 331271012317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271012318 Ligand Binding Site [chemical binding]; other site 331271012319 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271012320 Ligand Binding Site [chemical binding]; other site 331271012321 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 331271012322 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 331271012323 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 331271012324 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 331271012325 active site residue [active] 331271012326 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 331271012327 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271012328 Ligand Binding Site [chemical binding]; other site 331271012329 PAS domain S-box; Region: sensory_box; TIGR00229 331271012330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271012331 putative active site [active] 331271012332 heme pocket [chemical binding]; other site 331271012333 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 331271012334 Histidine kinase; Region: HisKA_3; pfam07730 331271012335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271012336 ATP binding site [chemical binding]; other site 331271012337 Mg2+ binding site [ion binding]; other site 331271012338 G-X-G motif; other site 331271012339 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271012340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271012341 active site 331271012342 phosphorylation site [posttranslational modification] 331271012343 intermolecular recognition site; other site 331271012344 dimerization interface [polypeptide binding]; other site 331271012345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271012346 DNA binding residues [nucleotide binding] 331271012347 dimerization interface [polypeptide binding]; other site 331271012348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 331271012349 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271012350 PilZ domain; Region: PilZ; pfam07238 331271012351 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 331271012352 Transglycosylase; Region: Transgly; pfam00912 331271012353 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331271012354 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 331271012355 Proline racemase; Region: Pro_racemase; pfam05544 331271012356 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271012357 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271012358 dimerization interface [polypeptide binding]; other site 331271012359 ligand binding site [chemical binding]; other site 331271012360 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271012361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271012362 DNA-binding site [nucleotide binding]; DNA binding site 331271012363 FCD domain; Region: FCD; pfam07729 331271012364 ornithine cyclodeaminase; Validated; Region: PRK07340 331271012365 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 331271012366 Response regulator receiver domain; Region: Response_reg; pfam00072 331271012367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271012368 active site 331271012369 phosphorylation site [posttranslational modification] 331271012370 intermolecular recognition site; other site 331271012371 dimerization interface [polypeptide binding]; other site 331271012372 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 331271012373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271012374 ligand binding site [chemical binding]; other site 331271012375 flexible hinge region; other site 331271012376 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 331271012377 putative switch regulator; other site 331271012378 non-specific DNA interactions [nucleotide binding]; other site 331271012379 DNA binding site [nucleotide binding] 331271012380 sequence specific DNA binding site [nucleotide binding]; other site 331271012381 putative cAMP binding site [chemical binding]; other site 331271012382 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 331271012383 Protein of unknown function, DUF488; Region: DUF488; cl01246 331271012384 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 331271012385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271012386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271012387 homodimer interface [polypeptide binding]; other site 331271012388 catalytic residue [active] 331271012389 aromatic amino acid transporter; Provisional; Region: PRK10238 331271012390 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271012391 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 331271012392 putative DNA binding site [nucleotide binding]; other site 331271012393 putative Zn2+ binding site [ion binding]; other site 331271012394 AsnC family; Region: AsnC_trans_reg; pfam01037 331271012395 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 331271012396 EamA-like transporter family; Region: EamA; cl17759 331271012397 EamA-like transporter family; Region: EamA; pfam00892 331271012398 Phosphoesterase family; Region: Phosphoesterase; pfam04185 331271012399 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 331271012400 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331271012401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271012402 S-adenosylmethionine binding site [chemical binding]; other site 331271012403 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271012404 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271012405 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 331271012406 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271012407 Walker A/P-loop; other site 331271012408 ATP binding site [chemical binding]; other site 331271012409 Q-loop/lid; other site 331271012410 ABC transporter signature motif; other site 331271012411 Walker B; other site 331271012412 D-loop; other site 331271012413 H-loop/switch region; other site 331271012414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271012415 dimer interface [polypeptide binding]; other site 331271012416 conserved gate region; other site 331271012417 putative PBP binding loops; other site 331271012418 ABC-ATPase subunit interface; other site 331271012419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271012420 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271012421 substrate binding pocket [chemical binding]; other site 331271012422 membrane-bound complex binding site; other site 331271012423 hinge residues; other site 331271012424 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271012425 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271012426 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271012427 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 331271012428 Transcriptional regulators [Transcription]; Region: GntR; COG1802 331271012429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 331271012430 FCD domain; Region: FCD; pfam07729 331271012431 short chain dehydrogenase; Provisional; Region: PRK12829 331271012432 classical (c) SDRs; Region: SDR_c; cd05233 331271012433 NAD(P) binding site [chemical binding]; other site 331271012434 active site 331271012435 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 331271012436 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271012437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012438 putative substrate translocation pore; other site 331271012439 HipA N-terminal domain; Region: Couple_hipA; pfam13657 331271012440 HipA-like N-terminal domain; Region: HipA_N; pfam07805 331271012441 HipA-like C-terminal domain; Region: HipA_C; pfam07804 331271012442 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271012443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271012444 non-specific DNA binding site [nucleotide binding]; other site 331271012445 salt bridge; other site 331271012446 sequence-specific DNA binding site [nucleotide binding]; other site 331271012447 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 331271012448 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 331271012449 putative ion selectivity filter; other site 331271012450 putative pore gating glutamate residue; other site 331271012451 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 331271012452 cytosine deaminase; Provisional; Region: PRK09230 331271012453 active site 331271012454 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271012455 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271012456 trimer interface [polypeptide binding]; other site 331271012457 eyelet of channel; other site 331271012458 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271012459 transcriptional regulator; Provisional; Region: PRK10632 331271012460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012461 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271012462 putative effector binding pocket; other site 331271012463 dimerization interface [polypeptide binding]; other site 331271012464 Fusaric acid resistance protein family; Region: FUSC; pfam04632 331271012465 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 331271012466 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 331271012467 homodimer interface [polypeptide binding]; other site 331271012468 homotetramer interface [polypeptide binding]; other site 331271012469 active site pocket [active] 331271012470 cleavage site 331271012471 amino acid transporter; Region: 2A0306; TIGR00909 331271012472 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271012473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271012474 DNA binding residues [nucleotide binding] 331271012475 dimerization interface [polypeptide binding]; other site 331271012476 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271012477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271012478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012479 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 331271012480 putative dimerization interface [polypeptide binding]; other site 331271012481 Predicted permeases [General function prediction only]; Region: COG0679 331271012482 EamA-like transporter family; Region: EamA; pfam00892 331271012483 EamA-like transporter family; Region: EamA; pfam00892 331271012484 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 331271012485 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 331271012486 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 331271012487 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 331271012488 tetrameric interface [polypeptide binding]; other site 331271012489 NAD binding site [chemical binding]; other site 331271012490 catalytic residues [active] 331271012491 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 331271012492 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271012493 inhibitor-cofactor binding pocket; inhibition site 331271012494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271012495 catalytic residue [active] 331271012496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271012497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012498 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271012499 dimerization interface [polypeptide binding]; other site 331271012500 H+ Antiporter protein; Region: 2A0121; TIGR00900 331271012501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012502 putative substrate translocation pore; other site 331271012503 MarR family; Region: MarR_2; pfam12802 331271012504 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 331271012505 Epoxide hydrolase N terminus; Region: EHN; pfam06441 331271012506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271012507 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271012508 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271012509 conserved cys residue [active] 331271012510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271012511 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 331271012512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271012513 NAD(P) binding site [chemical binding]; other site 331271012514 active site 331271012515 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271012516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 331271012518 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271012519 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 331271012520 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271012521 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271012522 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271012523 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 331271012524 putative DNA binding site [nucleotide binding]; other site 331271012525 putative Zn2+ binding site [ion binding]; other site 331271012526 AsnC family; Region: AsnC_trans_reg; pfam01037 331271012527 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271012528 voltage-gated potassium channel; Provisional; Region: PRK10537 331271012529 Ion channel; Region: Ion_trans_2; pfam07885 331271012530 TrkA-N domain; Region: TrkA_N; pfam02254 331271012531 Predicted membrane protein [Function unknown]; Region: COG1238 331271012532 Cache domain; Region: Cache_1; pfam02743 331271012533 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271012534 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271012535 dimer interface [polypeptide binding]; other site 331271012536 putative CheW interface [polypeptide binding]; other site 331271012537 acyl-CoA synthetase; Validated; Region: PRK08162 331271012538 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 331271012539 acyl-activating enzyme (AAE) consensus motif; other site 331271012540 putative active site [active] 331271012541 AMP binding site [chemical binding]; other site 331271012542 putative CoA binding site [chemical binding]; other site 331271012543 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271012544 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271012545 ligand binding site [chemical binding]; other site 331271012546 flexible hinge region; other site 331271012547 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 331271012548 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331271012549 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271012550 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271012551 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271012552 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 331271012553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271012554 active site 331271012555 phosphorylation site [posttranslational modification] 331271012556 intermolecular recognition site; other site 331271012557 dimerization interface [polypeptide binding]; other site 331271012558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271012559 DNA binding site [nucleotide binding] 331271012560 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 331271012561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 331271012562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271012563 dimer interface [polypeptide binding]; other site 331271012564 phosphorylation site [posttranslational modification] 331271012565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271012566 ATP binding site [chemical binding]; other site 331271012567 Mg2+ binding site [ion binding]; other site 331271012568 G-X-G motif; other site 331271012569 Cupin domain; Region: Cupin_2; cl17218 331271012570 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271012571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271012572 amidase; Provisional; Region: PRK07235 331271012573 amidase; Provisional; Region: PRK07487 331271012574 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 331271012575 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 331271012576 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 331271012577 putative TOMM peptide; Region: TOMM_nitrile_2; TIGR04351 331271012578 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 331271012579 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 331271012580 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 331271012581 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 331271012582 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 331271012583 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 331271012584 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271012585 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271012586 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271012587 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271012588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271012589 Inclusion body protein; Region: PixA; pfam12306 331271012590 Inclusion body protein; Region: PixA; pfam12306 331271012591 Inclusion body protein; Region: PixA; pfam12306 331271012592 short chain dehydrogenase; Provisional; Region: PRK06523 331271012593 classical (c) SDRs; Region: SDR_c; cd05233 331271012594 NAD(P) binding site [chemical binding]; other site 331271012595 active site 331271012596 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 331271012597 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 331271012598 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271012599 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 331271012600 active site 331271012601 FMN binding site [chemical binding]; other site 331271012602 substrate binding site [chemical binding]; other site 331271012603 homotetramer interface [polypeptide binding]; other site 331271012604 catalytic residue [active] 331271012605 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 331271012606 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 331271012607 potential catalytic triad [active] 331271012608 conserved cys residue [active] 331271012609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271012610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271012611 DNA binding site [nucleotide binding] 331271012612 domain linker motif; other site 331271012613 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 331271012614 ligand binding site [chemical binding]; other site 331271012615 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 331271012616 active site 331271012617 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 331271012618 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 331271012619 substrate binding [chemical binding]; other site 331271012620 active site 331271012621 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 331271012622 short chain dehydrogenase; Provisional; Region: PRK06500 331271012623 classical (c) SDRs; Region: SDR_c; cd05233 331271012624 NAD(P) binding site [chemical binding]; other site 331271012625 active site 331271012626 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 331271012627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271012629 dimerization interface [polypeptide binding]; other site 331271012630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271012631 DNA-binding site [nucleotide binding]; DNA binding site 331271012632 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271012633 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271012634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271012635 homodimer interface [polypeptide binding]; other site 331271012636 catalytic residue [active] 331271012637 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 331271012638 Uncharacterized conserved protein [Function unknown]; Region: COG2128 331271012639 Cupin domain; Region: Cupin_2; pfam07883 331271012640 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271012641 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271012642 trimer interface [polypeptide binding]; other site 331271012643 eyelet of channel; other site 331271012644 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 331271012645 active site lid residues [active] 331271012646 substrate binding pocket [chemical binding]; other site 331271012647 catalytic residues [active] 331271012648 substrate-Mg2+ binding site; other site 331271012649 aspartate-rich region 1; other site 331271012650 aspartate-rich region 2; other site 331271012651 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 331271012652 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 331271012653 putative active site [active] 331271012654 catalytic site [active] 331271012655 putative metal binding site [ion binding]; other site 331271012656 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 331271012657 active site residue [active] 331271012658 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 331271012659 active site residue [active] 331271012660 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 331271012661 active site residue [active] 331271012662 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 331271012663 active site residue [active] 331271012664 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 331271012665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271012666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271012668 dimerization interface [polypeptide binding]; other site 331271012669 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271012670 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 331271012671 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 331271012672 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 331271012673 dimer interface [polypeptide binding]; other site 331271012674 active site 331271012675 non-prolyl cis peptide bond; other site 331271012676 insertion regions; other site 331271012677 hypothetical protein; Provisional; Region: PRK06208 331271012678 active site 331271012679 intersubunit interface [polypeptide binding]; other site 331271012680 Zn2+ binding site [ion binding]; other site 331271012681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 331271012682 NMT1/THI5 like; Region: NMT1; pfam09084 331271012683 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271012684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271012685 dimer interface [polypeptide binding]; other site 331271012686 conserved gate region; other site 331271012687 putative PBP binding loops; other site 331271012688 ABC-ATPase subunit interface; other site 331271012689 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271012690 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271012691 Walker A/P-loop; other site 331271012692 ATP binding site [chemical binding]; other site 331271012693 Q-loop/lid; other site 331271012694 ABC transporter signature motif; other site 331271012695 Walker B; other site 331271012696 D-loop; other site 331271012697 H-loop/switch region; other site 331271012698 Cytochrome c; Region: Cytochrom_C; pfam00034 331271012699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 331271012700 membrane-bound complex binding site; other site 331271012701 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 331271012702 MOSC domain; Region: MOSC; pfam03473 331271012703 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 331271012704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 331271012705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271012706 dimer interface [polypeptide binding]; other site 331271012707 phosphorylation site [posttranslational modification] 331271012708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271012709 ATP binding site [chemical binding]; other site 331271012710 Mg2+ binding site [ion binding]; other site 331271012711 G-X-G motif; other site 331271012712 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 331271012713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271012714 active site 331271012715 phosphorylation site [posttranslational modification] 331271012716 intermolecular recognition site; other site 331271012717 dimerization interface [polypeptide binding]; other site 331271012718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271012719 DNA binding site [nucleotide binding] 331271012720 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 331271012721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012722 putative substrate translocation pore; other site 331271012723 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271012724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271012725 DNA-binding site [nucleotide binding]; DNA binding site 331271012726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271012727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271012728 homodimer interface [polypeptide binding]; other site 331271012729 catalytic residue [active] 331271012730 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 331271012731 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271012732 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 331271012733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271012734 dimer interface [polypeptide binding]; other site 331271012735 conserved gate region; other site 331271012736 ABC-ATPase subunit interface; other site 331271012737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271012738 dimer interface [polypeptide binding]; other site 331271012739 conserved gate region; other site 331271012740 putative PBP binding loops; other site 331271012741 ABC-ATPase subunit interface; other site 331271012742 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 331271012743 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 331271012744 Walker A/P-loop; other site 331271012745 ATP binding site [chemical binding]; other site 331271012746 Q-loop/lid; other site 331271012747 ABC transporter signature motif; other site 331271012748 Walker B; other site 331271012749 D-loop; other site 331271012750 H-loop/switch region; other site 331271012751 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271012752 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271012753 trimer interface [polypeptide binding]; other site 331271012754 eyelet of channel; other site 331271012755 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271012756 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 331271012757 NAD(P) binding site [chemical binding]; other site 331271012758 Cupin domain; Region: Cupin_2; cl17218 331271012759 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271012760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271012761 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 331271012762 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 331271012763 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 331271012764 putative substrate binding pocket [chemical binding]; other site 331271012765 trimer interface [polypeptide binding]; other site 331271012766 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 331271012767 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 331271012768 putative active site [active] 331271012769 putative metal binding site [ion binding]; other site 331271012770 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 331271012771 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 331271012772 NAD binding site [chemical binding]; other site 331271012773 catalytic residues [active] 331271012774 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 331271012775 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271012776 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 331271012777 MarR family; Region: MarR_2; cl17246 331271012778 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271012779 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 331271012780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271012781 NAD(P) binding site [chemical binding]; other site 331271012782 active site 331271012783 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 331271012784 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 331271012785 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331271012786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331271012787 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331271012788 putative cation:proton antiport protein; Provisional; Region: PRK10669 331271012789 TrkA-N domain; Region: TrkA_N; pfam02254 331271012790 Cytochrome c; Region: Cytochrom_C; pfam00034 331271012791 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271012792 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271012793 Cytochrome c; Region: Cytochrom_C; pfam00034 331271012794 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 331271012795 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 331271012796 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 331271012797 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 331271012798 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 331271012799 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 331271012800 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 331271012801 hexamer interface [polypeptide binding]; other site 331271012802 ligand binding site [chemical binding]; other site 331271012803 putative active site [active] 331271012804 NAD(P) binding site [chemical binding]; other site 331271012805 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 331271012806 hypothetical protein; Provisional; Region: PRK08609 331271012807 active site 331271012808 primer binding site [nucleotide binding]; other site 331271012809 NTP binding site [chemical binding]; other site 331271012810 metal binding triad [ion binding]; metal-binding site 331271012811 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 331271012812 active site 331271012813 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 331271012814 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 331271012815 Bacterial sugar transferase; Region: Bac_transf; pfam02397 331271012816 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271012817 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 331271012818 non-specific DNA interactions [nucleotide binding]; other site 331271012819 DNA binding site [nucleotide binding] 331271012820 sequence specific DNA binding site [nucleotide binding]; other site 331271012821 putative cAMP binding site [chemical binding]; other site 331271012822 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271012823 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271012824 ligand binding site [chemical binding]; other site 331271012825 flexible hinge region; other site 331271012826 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 331271012827 acyl carrier protein; Provisional; Region: PRK07081 331271012828 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271012829 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 331271012830 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271012831 active site 331271012832 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 331271012833 dimer interface [polypeptide binding]; other site 331271012834 motif 1; other site 331271012835 active site 331271012836 motif 2; other site 331271012837 motif 3; other site 331271012838 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 331271012839 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 331271012840 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331271012841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271012842 Walker A motif; other site 331271012843 ATP binding site [chemical binding]; other site 331271012844 Walker B motif; other site 331271012845 arginine finger; other site 331271012846 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271012847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271012848 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 331271012849 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 331271012850 Substrate binding site; other site 331271012851 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 331271012852 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 331271012853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271012854 putative ADP-binding pocket [chemical binding]; other site 331271012855 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 331271012856 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 331271012857 Chain length determinant protein; Region: Wzz; pfam02706 331271012858 tyrosine kinase; Provisional; Region: PRK11519 331271012859 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 331271012860 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331271012861 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 331271012862 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 331271012863 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 331271012864 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 331271012865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271012866 polysaccharide export protein Wza; Provisional; Region: PRK15078 331271012867 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 331271012868 SLBB domain; Region: SLBB; pfam10531 331271012869 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 331271012870 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 331271012871 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 331271012872 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 331271012873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271012875 dimerization interface [polypeptide binding]; other site 331271012876 Uncharacterized conserved protein [Function unknown]; Region: COG1739 331271012877 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 331271012878 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 331271012879 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 331271012880 OmpW family; Region: OmpW; cl17427 331271012881 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 331271012882 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271012883 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 331271012884 putative acyl-acceptor binding pocket; other site 331271012885 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 331271012886 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 331271012887 putative active site [active] 331271012888 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271012889 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 331271012890 Walker A/P-loop; other site 331271012891 ATP binding site [chemical binding]; other site 331271012892 Q-loop/lid; other site 331271012893 ABC transporter signature motif; other site 331271012894 Walker B; other site 331271012895 D-loop; other site 331271012896 H-loop/switch region; other site 331271012897 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331271012898 Predicted transcriptional regulators [Transcription]; Region: COG1733 331271012899 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 331271012900 haloalkane dehalogenase; Provisional; Region: PRK00870 331271012901 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 331271012902 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 331271012903 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 331271012904 putative transporter; Provisional; Region: PRK11021 331271012905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 331271012906 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 331271012907 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 331271012908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271012909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271012910 dimerization interface [polypeptide binding]; other site 331271012911 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271012912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271012913 non-specific DNA binding site [nucleotide binding]; other site 331271012914 salt bridge; other site 331271012915 sequence-specific DNA binding site [nucleotide binding]; other site 331271012916 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 331271012917 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 331271012918 heterodimer interface [polypeptide binding]; other site 331271012919 multimer interface [polypeptide binding]; other site 331271012920 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 331271012921 active site 331271012922 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 331271012923 heterodimer interface [polypeptide binding]; other site 331271012924 active site 331271012925 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271012926 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271012927 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271012928 catalytic site [active] 331271012929 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 331271012930 SxDxEG motif; other site 331271012931 active site 331271012932 metal binding site [ion binding]; metal-binding site 331271012933 homopentamer interface [polypeptide binding]; other site 331271012934 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 331271012935 homodimer interface [polypeptide binding]; other site 331271012936 homotetramer interface [polypeptide binding]; other site 331271012937 active site pocket [active] 331271012938 cleavage site 331271012939 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 331271012940 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 331271012941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271012942 dimer interface [polypeptide binding]; other site 331271012943 conserved gate region; other site 331271012944 putative PBP binding loops; other site 331271012945 ABC-ATPase subunit interface; other site 331271012946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271012947 dimer interface [polypeptide binding]; other site 331271012948 conserved gate region; other site 331271012949 ABC-ATPase subunit interface; other site 331271012950 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 331271012951 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 331271012952 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 331271012953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271012954 Walker A/P-loop; other site 331271012955 ATP binding site [chemical binding]; other site 331271012956 Q-loop/lid; other site 331271012957 ABC transporter signature motif; other site 331271012958 Walker B; other site 331271012959 D-loop; other site 331271012960 H-loop/switch region; other site 331271012961 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271012962 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271012963 Walker A/P-loop; other site 331271012964 ATP binding site [chemical binding]; other site 331271012965 Q-loop/lid; other site 331271012966 ABC transporter signature motif; other site 331271012967 Walker B; other site 331271012968 D-loop; other site 331271012969 H-loop/switch region; other site 331271012970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 331271012971 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 331271012972 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 331271012973 catalytic nucleophile [active] 331271012974 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 331271012975 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271012976 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 331271012977 putative active site [active] 331271012978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271012979 D-galactonate transporter; Region: 2A0114; TIGR00893 331271012980 putative substrate translocation pore; other site 331271012981 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 331271012982 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 331271012983 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 331271012984 putative active site [active] 331271012985 putative catalytic site [active] 331271012986 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271012987 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271012988 trimer interface [polypeptide binding]; other site 331271012989 eyelet of channel; other site 331271012990 BCCT family transporter; Region: BCCT; pfam02028 331271012991 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331271012992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271012993 S-adenosylmethionine binding site [chemical binding]; other site 331271012994 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 331271012995 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331271012996 active site 331271012997 metal binding site [ion binding]; metal-binding site 331271012998 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 331271012999 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271013000 benzoate transport; Region: 2A0115; TIGR00895 331271013001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013002 putative substrate translocation pore; other site 331271013003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013004 salicylate hydroxylase; Provisional; Region: PRK08163 331271013005 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271013006 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 331271013007 maleylacetoacetate isomerase; Region: maiA; TIGR01262 331271013008 C-terminal domain interface [polypeptide binding]; other site 331271013009 GSH binding site (G-site) [chemical binding]; other site 331271013010 putative dimer interface [polypeptide binding]; other site 331271013011 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 331271013012 dimer interface [polypeptide binding]; other site 331271013013 N-terminal domain interface [polypeptide binding]; other site 331271013014 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 331271013015 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331271013016 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271013017 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 331271013018 Cupin domain; Region: Cupin_2; pfam07883 331271013019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013020 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 331271013021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271013022 dimerization interface [polypeptide binding]; other site 331271013023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 331271013024 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 331271013025 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271013026 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271013027 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271013028 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 331271013029 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 331271013030 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271013031 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271013032 inhibitor site; inhibition site 331271013033 active site 331271013034 dimer interface [polypeptide binding]; other site 331271013035 catalytic residue [active] 331271013036 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 331271013037 Spore germination protein; Region: Spore_permease; cl17796 331271013038 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 331271013039 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 331271013040 dimer interface [polypeptide binding]; other site 331271013041 NADP binding site [chemical binding]; other site 331271013042 catalytic residues [active] 331271013043 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 331271013044 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 331271013045 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 331271013046 Bacterial SH3 domain; Region: SH3_3; pfam08239 331271013047 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 331271013048 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331271013049 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 331271013050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271013051 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331271013052 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 331271013053 DNA binding residues [nucleotide binding] 331271013054 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 331271013055 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 331271013056 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 331271013057 DNA binding residues [nucleotide binding] 331271013058 putative dimer interface [polypeptide binding]; other site 331271013059 putative metal binding residues [ion binding]; other site 331271013060 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 331271013061 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271013062 MarR family; Region: MarR_2; pfam12802 331271013063 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271013064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013065 putative substrate translocation pore; other site 331271013066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013067 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 331271013068 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 331271013069 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 331271013070 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 331271013071 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 331271013072 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 331271013073 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 331271013074 active site 331271013075 metal-binding site 331271013076 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 331271013077 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 331271013078 tetramer interface [polypeptide binding]; other site 331271013079 active site 331271013080 Mg2+/Mn2+ binding site [ion binding]; other site 331271013081 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 331271013082 active site 331271013083 metal-binding site 331271013084 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271013085 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 331271013086 PYR/PP interface [polypeptide binding]; other site 331271013087 dimer interface [polypeptide binding]; other site 331271013088 TPP binding site [chemical binding]; other site 331271013089 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 331271013090 TPP-binding site [chemical binding]; other site 331271013091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271013092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271013093 catalytic residue [active] 331271013094 Patatin-like phospholipase; Region: Patatin; pfam01734 331271013095 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 331271013096 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 331271013097 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 331271013098 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 331271013099 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 331271013100 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 331271013101 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 331271013102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 331271013103 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 331271013104 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 331271013105 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 331271013106 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 331271013107 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 331271013108 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 331271013109 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 331271013110 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 331271013111 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 331271013112 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 331271013113 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 331271013114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 331271013115 Uncharacterized conserved protein [Function unknown]; Region: COG2308 331271013116 cell density-dependent motility repressor; Provisional; Region: PRK10082 331271013117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271013119 dimerization interface [polypeptide binding]; other site 331271013120 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 331271013121 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 331271013122 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 331271013123 putative active site [active] 331271013124 putative metal binding site [ion binding]; other site 331271013125 N-glycosyltransferase; Provisional; Region: PRK11204 331271013126 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 331271013127 DXD motif; other site 331271013128 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331271013129 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331271013130 glutaminase active site [active] 331271013131 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331271013132 dimer interface [polypeptide binding]; other site 331271013133 active site 331271013134 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331271013135 dimer interface [polypeptide binding]; other site 331271013136 active site 331271013137 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271013138 Cytochrome c; Region: Cytochrom_C; pfam00034 331271013139 allantoate amidohydrolase; Reviewed; Region: PRK12891 331271013140 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 331271013141 active site 331271013142 metal binding site [ion binding]; metal-binding site 331271013143 dimer interface [polypeptide binding]; other site 331271013144 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 331271013145 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271013146 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271013147 dimerization interface [polypeptide binding]; other site 331271013148 ligand binding site [chemical binding]; other site 331271013149 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271013150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013151 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271013152 dimerization interface [polypeptide binding]; other site 331271013153 substrate binding pocket [chemical binding]; other site 331271013154 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331271013155 oligomeric interface; other site 331271013156 putative active site [active] 331271013157 homodimer interface [polypeptide binding]; other site 331271013158 peroxiredoxin; Region: AhpC; TIGR03137 331271013159 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 331271013160 dimer interface [polypeptide binding]; other site 331271013161 decamer (pentamer of dimers) interface [polypeptide binding]; other site 331271013162 catalytic triad [active] 331271013163 peroxidatic and resolving cysteines [active] 331271013164 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 331271013165 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 331271013166 catalytic residue [active] 331271013167 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 331271013168 catalytic residues [active] 331271013169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271013170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271013171 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 331271013172 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 331271013173 hypothetical protein; Provisional; Region: PRK07483 331271013174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271013175 inhibitor-cofactor binding pocket; inhibition site 331271013176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271013177 catalytic residue [active] 331271013178 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 331271013179 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 331271013180 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271013181 Walker A/P-loop; other site 331271013182 ATP binding site [chemical binding]; other site 331271013183 Q-loop/lid; other site 331271013184 ABC transporter signature motif; other site 331271013185 Walker B; other site 331271013186 D-loop; other site 331271013187 H-loop/switch region; other site 331271013188 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271013189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271013190 dimer interface [polypeptide binding]; other site 331271013191 conserved gate region; other site 331271013192 putative PBP binding loops; other site 331271013193 ABC-ATPase subunit interface; other site 331271013194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271013195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271013196 substrate binding pocket [chemical binding]; other site 331271013197 membrane-bound complex binding site; other site 331271013198 hinge residues; other site 331271013199 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331271013200 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271013201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271013202 Walker A/P-loop; other site 331271013203 ATP binding site [chemical binding]; other site 331271013204 Q-loop/lid; other site 331271013205 ABC transporter signature motif; other site 331271013206 Walker B; other site 331271013207 D-loop; other site 331271013208 H-loop/switch region; other site 331271013209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271013210 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 331271013211 Walker A/P-loop; other site 331271013212 ATP binding site [chemical binding]; other site 331271013213 Q-loop/lid; other site 331271013214 ABC transporter signature motif; other site 331271013215 Walker B; other site 331271013216 D-loop; other site 331271013217 H-loop/switch region; other site 331271013218 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271013219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271013221 dimerization interface [polypeptide binding]; other site 331271013222 MAPEG family; Region: MAPEG; cl09190 331271013223 alanine racemase; Reviewed; Region: PRK13340 331271013224 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 331271013225 active site 331271013226 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331271013227 substrate binding site [chemical binding]; other site 331271013228 catalytic residues [active] 331271013229 dimer interface [polypeptide binding]; other site 331271013230 enoyl-CoA hydratase; Validated; Region: PRK08139 331271013231 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271013232 substrate binding site [chemical binding]; other site 331271013233 oxyanion hole (OAH) forming residues; other site 331271013234 trimer interface [polypeptide binding]; other site 331271013235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013236 putative substrate translocation pore; other site 331271013237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271013238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013239 LysR substrate binding domain; Region: LysR_substrate; pfam03466 331271013240 dimerization interface [polypeptide binding]; other site 331271013241 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 331271013242 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331271013243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271013244 active site 331271013245 phosphorylation site [posttranslational modification] 331271013246 intermolecular recognition site; other site 331271013247 dimerization interface [polypeptide binding]; other site 331271013248 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 331271013249 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271013250 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 331271013251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271013252 dimerization interface [polypeptide binding]; other site 331271013253 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 331271013254 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 331271013255 putative binding surface; other site 331271013256 active site 331271013257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271013258 ATP binding site [chemical binding]; other site 331271013259 Mg2+ binding site [ion binding]; other site 331271013260 G-X-G motif; other site 331271013261 putative hydrolase; Provisional; Region: PRK11460 331271013262 L-asparagine permease; Provisional; Region: PRK15049 331271013263 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 331271013264 Aspartase; Region: Aspartase; cd01357 331271013265 active sites [active] 331271013266 tetramer interface [polypeptide binding]; other site 331271013267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271013268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013269 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271013270 putative effector binding pocket; other site 331271013271 dimerization interface [polypeptide binding]; other site 331271013272 L-asparaginase II; Region: Asparaginase_II; pfam06089 331271013273 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 331271013274 Predicted membrane protein [Function unknown]; Region: COG3817 331271013275 Protein of unknown function (DUF979); Region: DUF979; pfam06166 331271013276 Protein of unknown function (DUF969); Region: DUF969; pfam06149 331271013277 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 331271013278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271013279 active site 331271013280 phosphorylation site [posttranslational modification] 331271013281 intermolecular recognition site; other site 331271013282 CheB methylesterase; Region: CheB_methylest; pfam01339 331271013283 Response regulator receiver domain; Region: Response_reg; pfam00072 331271013284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271013285 active site 331271013286 phosphorylation site [posttranslational modification] 331271013287 intermolecular recognition site; other site 331271013288 dimerization interface [polypeptide binding]; other site 331271013289 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271013290 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271013291 metal binding site [ion binding]; metal-binding site 331271013292 active site 331271013293 I-site; other site 331271013294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 331271013295 GAF domain; Region: GAF; pfam01590 331271013296 PAS fold; Region: PAS; pfam00989 331271013297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 331271013298 putative active site [active] 331271013299 heme pocket [chemical binding]; other site 331271013300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271013301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271013302 metal binding site [ion binding]; metal-binding site 331271013303 active site 331271013304 I-site; other site 331271013305 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271013306 LysR family transcriptional regulator; Provisional; Region: PRK14997 331271013307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013308 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 331271013309 putative effector binding pocket; other site 331271013310 putative dimerization interface [polypeptide binding]; other site 331271013311 Isochorismatase family; Region: Isochorismatase; pfam00857 331271013312 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 331271013313 catalytic triad [active] 331271013314 dimer interface [polypeptide binding]; other site 331271013315 conserved cis-peptide bond; other site 331271013316 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 331271013317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271013318 motif II; other site 331271013319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271013320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271013322 dimerization interface [polypeptide binding]; other site 331271013323 shikimate transporter; Provisional; Region: PRK09952 331271013324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013325 putative substrate translocation pore; other site 331271013326 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 331271013327 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 331271013328 tetrameric interface [polypeptide binding]; other site 331271013329 NAD binding site [chemical binding]; other site 331271013330 catalytic residues [active] 331271013331 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271013332 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 331271013333 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331271013334 Cytochrome c; Region: Cytochrom_C; pfam00034 331271013335 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271013336 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 331271013337 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271013338 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271013339 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 331271013340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271013341 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271013342 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 331271013343 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 331271013344 Isochorismatase family; Region: Isochorismatase; pfam00857 331271013345 catalytic triad [active] 331271013346 conserved cis-peptide bond; other site 331271013347 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271013348 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271013349 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271013350 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271013351 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271013352 MarR family; Region: MarR_2; cl17246 331271013353 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271013354 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271013355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013356 putative substrate translocation pore; other site 331271013357 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 331271013358 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 331271013359 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 331271013360 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 331271013361 Na binding site [ion binding]; other site 331271013362 putative substrate binding site [chemical binding]; other site 331271013363 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 331271013364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271013365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271013367 dimerization interface [polypeptide binding]; other site 331271013368 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 331271013369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 331271013370 substrate binding pocket [chemical binding]; other site 331271013371 membrane-bound complex binding site; other site 331271013372 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 331271013373 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 331271013374 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 331271013375 Ligand binding site; other site 331271013376 Putative Catalytic site; other site 331271013377 DXD motif; other site 331271013378 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 331271013379 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 331271013380 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271013381 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271013382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271013383 dimer interface [polypeptide binding]; other site 331271013384 conserved gate region; other site 331271013385 ABC-ATPase subunit interface; other site 331271013386 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271013387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271013388 dimer interface [polypeptide binding]; other site 331271013389 putative PBP binding loops; other site 331271013390 ABC-ATPase subunit interface; other site 331271013391 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271013392 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271013393 Walker A/P-loop; other site 331271013394 ATP binding site [chemical binding]; other site 331271013395 Q-loop/lid; other site 331271013396 ABC transporter signature motif; other site 331271013397 Walker B; other site 331271013398 D-loop; other site 331271013399 H-loop/switch region; other site 331271013400 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 331271013401 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 331271013402 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331271013403 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 331271013404 peptide binding site [polypeptide binding]; other site 331271013405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 331271013406 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271013407 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271013408 substrate binding pocket [chemical binding]; other site 331271013409 membrane-bound complex binding site; other site 331271013410 hinge residues; other site 331271013411 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 331271013412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271013413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013414 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271013415 putative effector binding pocket; other site 331271013416 dimerization interface [polypeptide binding]; other site 331271013417 putrescine transporter; Provisional; Region: potE; PRK10655 331271013418 arginine decarboxylase; Provisional; Region: PRK15029 331271013419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271013420 active site 331271013421 phosphorylation site [posttranslational modification] 331271013422 intermolecular recognition site; other site 331271013423 dimerization interface [polypeptide binding]; other site 331271013424 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 331271013425 homodimer interface [polypeptide binding]; other site 331271013426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271013427 catalytic residue [active] 331271013428 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 331271013429 ornithine decarboxylase; Provisional; Region: PRK13578 331271013430 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 331271013431 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 331271013432 homodimer interface [polypeptide binding]; other site 331271013433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271013434 catalytic residue [active] 331271013435 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 331271013436 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271013437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013438 putative substrate translocation pore; other site 331271013439 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 331271013440 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 331271013441 putative active site [active] 331271013442 metal binding site [ion binding]; metal-binding site 331271013443 Uncharacterized conserved protein [Function unknown]; Region: COG1359 331271013444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271013445 C factor cell-cell signaling protein; Provisional; Region: PRK09009 331271013446 NAD(P) binding site [chemical binding]; other site 331271013447 active site 331271013448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271013449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013450 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 331271013451 putative substrate binding pocket [chemical binding]; other site 331271013452 putative dimerization interface [polypeptide binding]; other site 331271013453 xanthine permease; Region: pbuX; TIGR03173 331271013454 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 331271013455 nudix motif; other site 331271013456 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 331271013457 short chain dehydrogenase; Provisional; Region: PRK06523 331271013458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271013459 NAD(P) binding site [chemical binding]; other site 331271013460 active site 331271013461 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271013462 Predicted transcriptional regulators [Transcription]; Region: COG1733 331271013463 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 331271013464 amino acid transporter; Region: 2A0306; TIGR00909 331271013465 Predicted amidohydrolase [General function prediction only]; Region: COG0388 331271013466 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 331271013467 putative active site [active] 331271013468 catalytic triad [active] 331271013469 putative dimer interface [polypeptide binding]; other site 331271013470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271013471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271013472 DNA binding residues [nucleotide binding] 331271013473 dimerization interface [polypeptide binding]; other site 331271013474 Cupin; Region: Cupin_6; pfam12852 331271013475 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271013476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271013477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271013478 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 331271013479 NADP binding site [chemical binding]; other site 331271013480 putative substrate binding site [chemical binding]; other site 331271013481 active site 331271013482 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 331271013483 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 331271013484 G1 box; other site 331271013485 putative GEF interaction site [polypeptide binding]; other site 331271013486 GTP/Mg2+ binding site [chemical binding]; other site 331271013487 Switch I region; other site 331271013488 G2 box; other site 331271013489 G3 box; other site 331271013490 Switch II region; other site 331271013491 G4 box; other site 331271013492 G5 box; other site 331271013493 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 331271013494 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 331271013495 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 331271013496 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 331271013497 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 331271013498 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 331271013499 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 331271013500 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 331271013501 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 331271013502 4Fe-4S binding domain; Region: Fer4; cl02805 331271013503 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 331271013504 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331271013505 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331271013506 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 331271013507 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 331271013508 molybdopterin cofactor binding site; other site 331271013509 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331271013510 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 331271013511 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271013512 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271013513 trimer interface [polypeptide binding]; other site 331271013514 eyelet of channel; other site 331271013515 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 331271013516 dimer interface [polypeptide binding]; other site 331271013517 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 331271013518 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 331271013519 active site 331271013520 tetramer interface; other site 331271013521 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 331271013522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271013523 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 331271013524 putative ADP-binding pocket [chemical binding]; other site 331271013525 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 331271013526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271013527 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 331271013528 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 331271013529 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 331271013530 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 331271013531 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 331271013532 NADP-binding site; other site 331271013533 homotetramer interface [polypeptide binding]; other site 331271013534 substrate binding site [chemical binding]; other site 331271013535 homodimer interface [polypeptide binding]; other site 331271013536 active site 331271013537 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271013538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271013539 NAD(P) binding site [chemical binding]; other site 331271013540 active site 331271013541 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 331271013542 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 331271013543 putative active site [active] 331271013544 putative NTP binding site [chemical binding]; other site 331271013545 putative nucleic acid binding site [nucleotide binding]; other site 331271013546 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 331271013547 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 331271013548 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 331271013549 homodimer interface [polypeptide binding]; other site 331271013550 substrate-cofactor binding pocket; other site 331271013551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271013552 catalytic residue [active] 331271013553 amidophosphoribosyltransferase; Provisional; Region: PRK09246 331271013554 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 331271013555 active site 331271013556 tetramer interface [polypeptide binding]; other site 331271013557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271013558 active site 331271013559 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 331271013560 Colicin V production protein; Region: Colicin_V; pfam02674 331271013561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 331271013562 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 331271013563 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331271013564 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331271013565 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 331271013566 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 331271013567 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 331271013568 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 331271013569 substrate binding site [chemical binding]; other site 331271013570 active site 331271013571 catalytic residues [active] 331271013572 heterodimer interface [polypeptide binding]; other site 331271013573 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 331271013574 DNA methylase; Region: N6_N4_Mtase; pfam01555 331271013575 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 331271013576 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 331271013577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271013578 catalytic residue [active] 331271013579 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 331271013580 active site 331271013581 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 331271013582 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 331271013583 dimerization interface 3.5A [polypeptide binding]; other site 331271013584 active site 331271013585 FimV N-terminal domain; Region: FimV_core; TIGR03505 331271013586 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 331271013587 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 331271013588 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 331271013589 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 331271013590 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 331271013591 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 331271013592 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 331271013593 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 331271013594 tartrate dehydrogenase; Region: TTC; TIGR02089 331271013595 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 331271013596 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 331271013597 substrate binding site [chemical binding]; other site 331271013598 Entericidin EcnA/B family; Region: Entericidin; cl02322 331271013599 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 331271013600 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 331271013601 substrate binding site [chemical binding]; other site 331271013602 ligand binding site [chemical binding]; other site 331271013603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271013604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271013605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271013606 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 331271013607 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 331271013608 glutathione s-transferase; Provisional; Region: PTZ00057 331271013609 GSH binding site (G-site) [chemical binding]; other site 331271013610 C-terminal domain interface [polypeptide binding]; other site 331271013611 dimer interface [polypeptide binding]; other site 331271013612 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 331271013613 dimer interface [polypeptide binding]; other site 331271013614 N-terminal domain interface [polypeptide binding]; other site 331271013615 substrate binding pocket (H-site) [chemical binding]; other site 331271013616 lysine transporter; Provisional; Region: PRK10836 331271013617 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271013618 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 331271013619 AsnC family; Region: AsnC_trans_reg; pfam01037 331271013620 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 331271013621 Amidinotransferase; Region: Amidinotransf; cl12043 331271013622 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 331271013623 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 331271013624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271013625 Cupin domain; Region: Cupin_2; cl17218 331271013626 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271013627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271013628 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 331271013629 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 331271013630 dimer interface [polypeptide binding]; other site 331271013631 active site 331271013632 citrylCoA binding site [chemical binding]; other site 331271013633 NADH binding [chemical binding]; other site 331271013634 cationic pore residues; other site 331271013635 oxalacetate/citrate binding site [chemical binding]; other site 331271013636 coenzyme A binding site [chemical binding]; other site 331271013637 catalytic triad [active] 331271013638 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 331271013639 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 331271013640 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 331271013641 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 331271013642 L-aspartate oxidase; Provisional; Region: PRK06175 331271013643 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331271013644 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 331271013645 SdhC subunit interface [polypeptide binding]; other site 331271013646 proximal heme binding site [chemical binding]; other site 331271013647 cardiolipin binding site; other site 331271013648 Iron-sulfur protein interface; other site 331271013649 proximal quinone binding site [chemical binding]; other site 331271013650 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 331271013651 Iron-sulfur protein interface; other site 331271013652 proximal quinone binding site [chemical binding]; other site 331271013653 SdhD (CybS) interface [polypeptide binding]; other site 331271013654 proximal heme binding site [chemical binding]; other site 331271013655 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 331271013656 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271013657 DNA-binding site [nucleotide binding]; DNA binding site 331271013658 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 331271013659 malate dehydrogenase; Provisional; Region: PRK05442 331271013660 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 331271013661 NAD(P) binding site [chemical binding]; other site 331271013662 dimer interface [polypeptide binding]; other site 331271013663 malate binding site [chemical binding]; other site 331271013664 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 331271013665 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 331271013666 2-methylcitrate dehydratase; Region: prpD; TIGR02330 331271013667 aconitate hydratase; Provisional; Region: acnA; PRK12881 331271013668 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 331271013669 substrate binding site [chemical binding]; other site 331271013670 ligand binding site [chemical binding]; other site 331271013671 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 331271013672 substrate binding site [chemical binding]; other site 331271013673 Domain of unknown function (DU1801); Region: DUF1801; cl17490 331271013674 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 331271013675 putative hydrophobic ligand binding site [chemical binding]; other site 331271013676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271013677 dimerization interface [polypeptide binding]; other site 331271013678 putative DNA binding site [nucleotide binding]; other site 331271013679 putative Zn2+ binding site [ion binding]; other site 331271013680 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 331271013681 peptidase domain interface [polypeptide binding]; other site 331271013682 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 331271013683 active site 331271013684 catalytic triad [active] 331271013685 calcium binding site [ion binding]; other site 331271013686 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271013687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013689 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271013690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271013691 dimer interface [polypeptide binding]; other site 331271013692 conserved gate region; other site 331271013693 putative PBP binding loops; other site 331271013694 ABC-ATPase subunit interface; other site 331271013695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271013696 dimer interface [polypeptide binding]; other site 331271013697 conserved gate region; other site 331271013698 putative PBP binding loops; other site 331271013699 ABC-ATPase subunit interface; other site 331271013700 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 331271013701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 331271013702 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 331271013703 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 331271013704 Walker A/P-loop; other site 331271013705 ATP binding site [chemical binding]; other site 331271013706 Q-loop/lid; other site 331271013707 ABC transporter signature motif; other site 331271013708 Walker B; other site 331271013709 D-loop; other site 331271013710 H-loop/switch region; other site 331271013711 TOBE domain; Region: TOBE_2; pfam08402 331271013712 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271013713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271013714 DNA-binding site [nucleotide binding]; DNA binding site 331271013715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271013716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271013717 homodimer interface [polypeptide binding]; other site 331271013718 catalytic residue [active] 331271013719 lipase chaperone; Provisional; Region: PRK01294 331271013720 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 331271013721 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 331271013722 Lipase (class 2); Region: Lipase_2; pfam01674 331271013723 PGAP1-like protein; Region: PGAP1; pfam07819 331271013724 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 331271013725 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271013726 N-terminal plug; other site 331271013727 ligand-binding site [chemical binding]; other site 331271013728 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 331271013729 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 331271013730 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 331271013731 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331271013732 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 331271013733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271013734 E3 interaction surface; other site 331271013735 lipoyl attachment site [posttranslational modification]; other site 331271013736 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271013737 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271013738 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 331271013739 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 331271013740 Methyltransferase domain; Region: Methyltransf_23; pfam13489 331271013741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271013742 S-adenosylmethionine binding site [chemical binding]; other site 331271013743 NAD-dependent deacetylase; Provisional; Region: PRK05333 331271013744 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 331271013745 NAD+ binding site [chemical binding]; other site 331271013746 substrate binding site [chemical binding]; other site 331271013747 Zn binding site [ion binding]; other site 331271013748 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 331271013749 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 331271013750 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 331271013751 putative mechanosensitive channel protein; Provisional; Region: PRK11465 331271013752 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271013753 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 331271013754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271013755 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 331271013756 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 331271013757 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271013758 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271013759 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271013760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013761 putative substrate translocation pore; other site 331271013762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013763 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 331271013764 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 331271013765 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 331271013766 tetramer interface [polypeptide binding]; other site 331271013767 heme binding pocket [chemical binding]; other site 331271013768 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 331271013769 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 331271013770 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 331271013771 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271013772 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271013773 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271013774 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 331271013775 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271013776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271013777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271013778 active site 331271013779 phosphorylation site [posttranslational modification] 331271013780 intermolecular recognition site; other site 331271013781 dimerization interface [polypeptide binding]; other site 331271013782 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271013783 DNA binding site [nucleotide binding] 331271013784 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 331271013785 peptidase domain interface [polypeptide binding]; other site 331271013786 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 331271013787 active site 331271013788 catalytic triad [active] 331271013789 calcium binding site [ion binding]; other site 331271013790 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 331271013791 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 331271013792 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271013793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271013794 DNA-binding site [nucleotide binding]; DNA binding site 331271013795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271013796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271013797 homodimer interface [polypeptide binding]; other site 331271013798 catalytic residue [active] 331271013799 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 331271013800 PLD-like domain; Region: PLDc_2; pfam13091 331271013801 putative active site [active] 331271013802 catalytic site [active] 331271013803 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 331271013804 PLD-like domain; Region: PLDc_2; pfam13091 331271013805 putative active site [active] 331271013806 catalytic site [active] 331271013807 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 331271013808 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 331271013809 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331271013810 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 331271013811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271013812 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331271013813 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271013814 DNA binding residues [nucleotide binding] 331271013815 DNA primase; Validated; Region: dnaG; PRK05667 331271013816 CHC2 zinc finger; Region: zf-CHC2; pfam01807 331271013817 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 331271013818 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 331271013819 active site 331271013820 metal binding site [ion binding]; metal-binding site 331271013821 interdomain interaction site; other site 331271013822 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 331271013823 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 331271013824 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 331271013825 Predicted flavoproteins [General function prediction only]; Region: COG2081 331271013826 UGMP family protein; Validated; Region: PRK09604 331271013827 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 331271013828 putative GTP cyclohydrolase; Provisional; Region: PRK13674 331271013829 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 331271013830 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 331271013831 TPP-binding site; other site 331271013832 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331271013833 PYR/PP interface [polypeptide binding]; other site 331271013834 dimer interface [polypeptide binding]; other site 331271013835 TPP binding site [chemical binding]; other site 331271013836 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331271013837 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 331271013838 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 331271013839 substrate binding pocket [chemical binding]; other site 331271013840 chain length determination region; other site 331271013841 substrate-Mg2+ binding site; other site 331271013842 catalytic residues [active] 331271013843 aspartate-rich region 1; other site 331271013844 active site lid residues [active] 331271013845 aspartate-rich region 2; other site 331271013846 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 331271013847 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 331271013848 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 331271013849 [2Fe-2S] cluster binding site [ion binding]; other site 331271013850 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 331271013851 alpha subunit interface [polypeptide binding]; other site 331271013852 active site 331271013853 substrate binding site [chemical binding]; other site 331271013854 Fe binding site [ion binding]; other site 331271013855 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 331271013856 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 331271013857 active site residue [active] 331271013858 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 331271013859 active site residue [active] 331271013860 Dienelactone hydrolase family; Region: DLH; pfam01738 331271013861 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 331271013862 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331271013863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271013864 DNA polymerase I; Provisional; Region: PRK05755 331271013865 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 331271013866 active site 331271013867 metal binding site 1 [ion binding]; metal-binding site 331271013868 putative 5' ssDNA interaction site; other site 331271013869 metal binding site 3; metal-binding site 331271013870 metal binding site 2 [ion binding]; metal-binding site 331271013871 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 331271013872 putative DNA binding site [nucleotide binding]; other site 331271013873 putative metal binding site [ion binding]; other site 331271013874 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 331271013875 active site 331271013876 catalytic site [active] 331271013877 substrate binding site [chemical binding]; other site 331271013878 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 331271013879 active site 331271013880 DNA binding site [nucleotide binding] 331271013881 catalytic site [active] 331271013882 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 331271013883 AMP nucleosidase; Provisional; Region: PRK08292 331271013884 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 331271013885 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 331271013886 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 331271013887 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 331271013888 putative active site [active] 331271013889 putative substrate binding site [chemical binding]; other site 331271013890 ATP binding site [chemical binding]; other site 331271013891 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271013892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271013893 putative Zn2+ binding site [ion binding]; other site 331271013894 putative DNA binding site [nucleotide binding]; other site 331271013895 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 331271013896 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 331271013897 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 331271013898 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 331271013899 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 331271013900 active site 331271013901 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 331271013902 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 331271013903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271013904 dimer interface [polypeptide binding]; other site 331271013905 conserved gate region; other site 331271013906 putative PBP binding loops; other site 331271013907 ABC-ATPase subunit interface; other site 331271013908 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 331271013909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271013910 Walker A/P-loop; other site 331271013911 ATP binding site [chemical binding]; other site 331271013912 Q-loop/lid; other site 331271013913 ABC transporter signature motif; other site 331271013914 Walker B; other site 331271013915 D-loop; other site 331271013916 H-loop/switch region; other site 331271013917 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 331271013918 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 331271013919 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 331271013920 molybdenum-pterin binding domain; Region: Mop; TIGR00638 331271013921 CHAD domain; Region: CHAD; pfam05235 331271013922 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 331271013923 active site 1 [active] 331271013924 dimer interface [polypeptide binding]; other site 331271013925 hexamer interface [polypeptide binding]; other site 331271013926 active site 2 [active] 331271013927 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 331271013928 active site 1 [active] 331271013929 dimer interface [polypeptide binding]; other site 331271013930 hexamer interface [polypeptide binding]; other site 331271013931 active site 2 [active] 331271013932 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271013933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271013934 LysR substrate binding domain; Region: LysR_substrate; pfam03466 331271013935 dimerization interface [polypeptide binding]; other site 331271013936 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331271013937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271013938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271013939 dimer interface [polypeptide binding]; other site 331271013940 phosphorylation site [posttranslational modification] 331271013941 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 331271013942 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 331271013943 Domain of unknown function DUF21; Region: DUF21; pfam01595 331271013944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331271013945 Transporter associated domain; Region: CorC_HlyC; smart01091 331271013946 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 331271013947 active site 331271013948 thiamine phosphate binding site [chemical binding]; other site 331271013949 pyrophosphate binding site [ion binding]; other site 331271013950 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 331271013951 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 331271013952 active site 331271013953 catalytic site [active] 331271013954 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 331271013955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271013956 S-adenosylmethionine binding site [chemical binding]; other site 331271013957 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271013958 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 331271013959 putative C-terminal domain interface [polypeptide binding]; other site 331271013960 putative GSH binding site (G-site) [chemical binding]; other site 331271013961 putative dimer interface [polypeptide binding]; other site 331271013962 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 331271013963 putative N-terminal domain interface [polypeptide binding]; other site 331271013964 putative dimer interface [polypeptide binding]; other site 331271013965 putative substrate binding pocket (H-site) [chemical binding]; other site 331271013966 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 331271013967 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 331271013968 active site 331271013969 metal binding site [ion binding]; metal-binding site 331271013970 RES domain; Region: RES; smart00953 331271013971 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 331271013972 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 331271013973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271013974 substrate binding pocket [chemical binding]; other site 331271013975 membrane-bound complex binding site; other site 331271013976 hinge residues; other site 331271013977 Predicted membrane protein [Function unknown]; Region: COG2246 331271013978 GtrA-like protein; Region: GtrA; pfam04138 331271013979 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 331271013980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271013981 Walker A motif; other site 331271013982 ATP binding site [chemical binding]; other site 331271013983 Walker B motif; other site 331271013984 arginine finger; other site 331271013985 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271013986 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 331271013987 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 331271013988 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 331271013989 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 331271013990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271013991 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271013992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271013993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331271013994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271013995 Coenzyme A binding pocket [chemical binding]; other site 331271013996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013997 putative substrate translocation pore; other site 331271013998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271013999 Predicted transcriptional regulators [Transcription]; Region: COG1733 331271014000 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 331271014001 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271014002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271014004 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 331271014005 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 331271014006 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 331271014007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331271014008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271014009 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331271014010 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331271014011 active site 331271014012 tyrosine kinase; Provisional; Region: PRK11519 331271014013 Chain length determinant protein; Region: Wzz; pfam02706 331271014014 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 331271014015 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271014016 P-loop; other site 331271014017 Magnesium ion binding site [ion binding]; other site 331271014018 polysaccharide export protein Wza; Provisional; Region: PRK15078 331271014019 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 331271014020 SLBB domain; Region: SLBB; pfam10531 331271014021 SLBB domain; Region: SLBB; pfam10531 331271014022 Low molecular weight phosphatase family; Region: LMWPc; cd00115 331271014023 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 331271014024 active site 331271014025 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 331271014026 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 331271014027 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 331271014028 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 331271014029 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 331271014030 Bacterial sugar transferase; Region: Bac_transf; pfam02397 331271014031 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 331271014032 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 331271014033 Substrate binding site; other site 331271014034 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 331271014035 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 331271014036 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 331271014037 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331271014038 Rubrerythrin [Energy production and conversion]; Region: COG1592 331271014039 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 331271014040 binuclear metal center [ion binding]; other site 331271014041 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 331271014042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271014043 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271014044 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 331271014045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 331271014046 YCII-related domain; Region: YCII; cl00999 331271014047 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 331271014048 generic binding surface I; other site 331271014049 generic binding surface II; other site 331271014050 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 331271014051 putative active site [active] 331271014052 putative catalytic site [active] 331271014053 putative Mg binding site IVb [ion binding]; other site 331271014054 putative DNA binding site [nucleotide binding]; other site 331271014055 putative phosphate binding site [ion binding]; other site 331271014056 putative Mg binding site IVa [ion binding]; other site 331271014057 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 331271014058 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 331271014059 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 331271014060 Domain of unknown function DUF20; Region: UPF0118; pfam01594 331271014061 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 331271014062 Prostaglandin dehydrogenases; Region: PGDH; cd05288 331271014063 NAD(P) binding site [chemical binding]; other site 331271014064 substrate binding site [chemical binding]; other site 331271014065 dimer interface [polypeptide binding]; other site 331271014066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271014067 short chain dehydrogenase; Validated; Region: PRK07069 331271014068 NAD(P) binding site [chemical binding]; other site 331271014069 active site 331271014070 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 331271014071 active site 331271014072 manganese transport protein MntH; Reviewed; Region: PRK00701 331271014073 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 331271014074 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271014075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014077 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 331271014078 substrate binding pocket [chemical binding]; other site 331271014079 dimerization interface [polypeptide binding]; other site 331271014080 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 331271014081 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 331271014082 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331271014083 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271014084 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 331271014085 Walker A/P-loop; other site 331271014086 ATP binding site [chemical binding]; other site 331271014087 Q-loop/lid; other site 331271014088 ABC transporter signature motif; other site 331271014089 Walker B; other site 331271014090 D-loop; other site 331271014091 H-loop/switch region; other site 331271014092 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271014093 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271014094 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 331271014095 Lumazine binding domain; Region: Lum_binding; pfam00677 331271014096 Lumazine binding domain; Region: Lum_binding; pfam00677 331271014097 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 331271014098 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 331271014099 putative Cl- selectivity filter; other site 331271014100 putative pore gating glutamate residue; other site 331271014101 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 331271014102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014103 active site 331271014104 phosphorylation site [posttranslational modification] 331271014105 intermolecular recognition site; other site 331271014106 dimerization interface [polypeptide binding]; other site 331271014107 CheB methylesterase; Region: CheB_methylest; pfam01339 331271014108 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 331271014109 putative binding surface; other site 331271014110 active site 331271014111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271014112 ATP binding site [chemical binding]; other site 331271014113 Mg2+ binding site [ion binding]; other site 331271014114 G-X-G motif; other site 331271014115 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 331271014116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014117 Response regulator receiver domain; Region: Response_reg; pfam00072 331271014118 active site 331271014119 phosphorylation site [posttranslational modification] 331271014120 intermolecular recognition site; other site 331271014121 dimerization interface [polypeptide binding]; other site 331271014122 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 331271014123 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 331271014124 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 331271014125 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331271014126 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 331271014127 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 331271014128 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 331271014129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271014130 dimerization interface [polypeptide binding]; other site 331271014131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271014132 dimer interface [polypeptide binding]; other site 331271014133 putative CheW interface [polypeptide binding]; other site 331271014134 Response regulator receiver domain; Region: Response_reg; pfam00072 331271014135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014136 active site 331271014137 phosphorylation site [posttranslational modification] 331271014138 intermolecular recognition site; other site 331271014139 dimerization interface [polypeptide binding]; other site 331271014140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 331271014141 dimer interface [polypeptide binding]; other site 331271014142 phosphorylation site [posttranslational modification] 331271014143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271014144 Mg2+ binding site [ion binding]; other site 331271014145 G-X-G motif; other site 331271014146 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 331271014147 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 331271014148 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271014149 NAD(P) binding site [chemical binding]; other site 331271014150 catalytic residues [active] 331271014151 acetolactate synthase; Reviewed; Region: PRK08322 331271014152 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271014153 PYR/PP interface [polypeptide binding]; other site 331271014154 dimer interface [polypeptide binding]; other site 331271014155 TPP binding site [chemical binding]; other site 331271014156 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271014157 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 331271014158 TPP-binding site [chemical binding]; other site 331271014159 dimer interface [polypeptide binding]; other site 331271014160 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 331271014161 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 331271014162 Protein of unknown function (DUF445); Region: DUF445; pfam04286 331271014163 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 331271014164 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271014165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271014166 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 331271014167 [2Fe-2S] cluster binding site [ion binding]; other site 331271014168 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 331271014169 inter-subunit interface; other site 331271014170 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 331271014171 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 331271014172 putative alpha subunit interface [polypeptide binding]; other site 331271014173 putative active site [active] 331271014174 putative substrate binding site [chemical binding]; other site 331271014175 Fe binding site [ion binding]; other site 331271014176 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271014177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271014178 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 331271014179 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 331271014180 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271014181 dimerization interface [polypeptide binding]; other site 331271014182 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271014183 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271014184 dimer interface [polypeptide binding]; other site 331271014185 putative CheW interface [polypeptide binding]; other site 331271014186 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 331271014187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014188 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 331271014189 dimerizarion interface [polypeptide binding]; other site 331271014190 CrgA pocket; other site 331271014191 substrate binding pocket [chemical binding]; other site 331271014192 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 331271014193 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 331271014194 octamer interface [polypeptide binding]; other site 331271014195 active site 331271014196 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 331271014197 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 331271014198 dimer interface [polypeptide binding]; other site 331271014199 active site 331271014200 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 331271014201 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 331271014202 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271014203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014205 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 331271014206 putative substrate binding pocket [chemical binding]; other site 331271014207 putative dimerization interface [polypeptide binding]; other site 331271014208 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 331271014209 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271014210 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 331271014211 active site 331271014212 FMN binding site [chemical binding]; other site 331271014213 2,4-decadienoyl-CoA binding site; other site 331271014214 catalytic residue [active] 331271014215 4Fe-4S cluster binding site [ion binding]; other site 331271014216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271014217 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271014218 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271014219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271014220 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 331271014221 substrate binding site [chemical binding]; other site 331271014222 Protein of unknown function (DUF521); Region: DUF521; pfam04412 331271014223 Putative Aconitase X catalytic domain; Region: AcnX; cd01355 331271014224 substrate binding site [chemical binding]; other site 331271014225 ligand binding site [chemical binding]; other site 331271014226 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271014227 MarR family; Region: MarR_2; pfam12802 331271014228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014230 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271014231 putative effector binding pocket; other site 331271014232 dimerization interface [polypeptide binding]; other site 331271014233 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271014234 MarR family; Region: MarR_2; pfam12802 331271014235 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 331271014236 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271014237 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271014238 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271014239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014240 putative substrate translocation pore; other site 331271014241 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271014242 Transposase, Mutator family; Region: Transposase_mut; pfam00872 331271014243 MULE transposase domain; Region: MULE; pfam10551 331271014244 PAAR motif; Region: PAAR_motif; pfam05488 331271014245 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 331271014246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 331271014247 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 331271014248 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 331271014249 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 331271014250 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 331271014251 glutathione S-transferase; Provisional; Region: PRK15113 331271014252 TIGR02594 family protein; Region: TIGR02594 331271014253 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271014254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014255 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271014256 dimerization interface [polypeptide binding]; other site 331271014257 substrate binding pocket [chemical binding]; other site 331271014258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014259 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271014260 putative substrate translocation pore; other site 331271014261 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271014262 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 331271014263 Amidohydrolase; Region: Amidohydro_4; pfam13147 331271014264 active site 331271014265 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271014266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014267 active site 331271014268 phosphorylation site [posttranslational modification] 331271014269 intermolecular recognition site; other site 331271014270 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271014271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014272 active site 331271014273 phosphorylation site [posttranslational modification] 331271014274 intermolecular recognition site; other site 331271014275 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 331271014276 Cache domain; Region: Cache_1; pfam02743 331271014277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271014278 dimerization interface [polypeptide binding]; other site 331271014279 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271014280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271014281 dimer interface [polypeptide binding]; other site 331271014282 putative CheW interface [polypeptide binding]; other site 331271014283 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 331271014284 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 331271014285 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271014286 ligand binding site [chemical binding]; other site 331271014287 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 331271014288 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271014289 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271014290 ligand binding site [chemical binding]; other site 331271014291 flexible hinge region; other site 331271014292 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 331271014293 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271014294 putative C-terminal domain interface [polypeptide binding]; other site 331271014295 putative GSH binding site (G-site) [chemical binding]; other site 331271014296 putative dimer interface [polypeptide binding]; other site 331271014297 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 331271014298 putative N-terminal domain interface [polypeptide binding]; other site 331271014299 putative dimer interface [polypeptide binding]; other site 331271014300 putative substrate binding pocket (H-site) [chemical binding]; other site 331271014301 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 331271014302 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 331271014303 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 331271014304 Cupin domain; Region: Cupin_2; cl17218 331271014305 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 331271014306 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271014307 Walker A/P-loop; other site 331271014308 ATP binding site [chemical binding]; other site 331271014309 Q-loop/lid; other site 331271014310 ABC transporter signature motif; other site 331271014311 Walker B; other site 331271014312 D-loop; other site 331271014313 H-loop/switch region; other site 331271014314 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271014315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271014316 dimer interface [polypeptide binding]; other site 331271014317 conserved gate region; other site 331271014318 putative PBP binding loops; other site 331271014319 ABC-ATPase subunit interface; other site 331271014320 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271014321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271014322 dimer interface [polypeptide binding]; other site 331271014323 conserved gate region; other site 331271014324 putative PBP binding loops; other site 331271014325 ABC-ATPase subunit interface; other site 331271014326 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271014327 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271014328 trimer interface [polypeptide binding]; other site 331271014329 eyelet of channel; other site 331271014330 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 331271014331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271014332 DNA-binding site [nucleotide binding]; DNA binding site 331271014333 UTRA domain; Region: UTRA; pfam07702 331271014334 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 331271014335 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 331271014336 homodimer interface [polypeptide binding]; other site 331271014337 active site 331271014338 TDP-binding site; other site 331271014339 acceptor substrate-binding pocket; other site 331271014340 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271014341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271014342 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271014343 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 331271014344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014345 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 331271014346 dimerizarion interface [polypeptide binding]; other site 331271014347 CrgA pocket; other site 331271014348 substrate binding pocket [chemical binding]; other site 331271014349 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 331271014350 lysine transporter; Provisional; Region: PRK10836 331271014351 Cache domain; Region: Cache_1; pfam02743 331271014352 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271014353 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271014354 metal binding site [ion binding]; metal-binding site 331271014355 active site 331271014356 I-site; other site 331271014357 Predicted membrane protein [Function unknown]; Region: COG1289 331271014358 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 331271014359 argininosuccinate synthase; Validated; Region: PRK05370 331271014360 argininosuccinate synthase; Provisional; Region: PRK13820 331271014361 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 331271014362 active site 331271014363 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271014364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014365 putative substrate translocation pore; other site 331271014366 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 331271014367 tartrate dehydrogenase; Region: TTC; TIGR02089 331271014368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014369 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 331271014370 putative effector binding pocket; other site 331271014371 putative dimerization interface [polypeptide binding]; other site 331271014372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014374 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271014375 putative effector binding pocket; other site 331271014376 putative dimerization interface [polypeptide binding]; other site 331271014377 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271014378 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271014379 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 331271014380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271014381 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271014382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271014383 S-adenosylmethionine binding site [chemical binding]; other site 331271014384 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 331271014385 4-hydroxyphenylacetate 3-hydroxylase N terminal; Region: HpaB_N; pfam11794 331271014386 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 331271014387 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 331271014388 cysteine desulfurase; Provisional; Region: PRK14012 331271014389 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 331271014390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271014391 catalytic residue [active] 331271014392 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271014393 MarR family; Region: MarR_2; pfam12802 331271014394 SnoaL-like domain; Region: SnoaL_4; pfam13577 331271014395 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 331271014396 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 331271014397 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 331271014398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271014399 Walker A motif; other site 331271014400 ATP binding site [chemical binding]; other site 331271014401 Walker B motif; other site 331271014402 arginine finger; other site 331271014403 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331271014404 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 331271014405 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 331271014406 hypothetical protein; Reviewed; Region: PRK09588 331271014407 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 331271014408 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 331271014409 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 331271014410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271014411 S-adenosylmethionine binding site [chemical binding]; other site 331271014412 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 331271014413 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 331271014414 homodimer interface [polypeptide binding]; other site 331271014415 substrate-cofactor binding pocket; other site 331271014416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271014417 catalytic residue [active] 331271014418 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271014419 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271014420 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271014421 trimer interface [polypeptide binding]; other site 331271014422 eyelet of channel; other site 331271014423 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271014424 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 331271014425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271014426 dimerization interface [polypeptide binding]; other site 331271014427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271014428 dimer interface [polypeptide binding]; other site 331271014429 phosphorylation site [posttranslational modification] 331271014430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271014431 ATP binding site [chemical binding]; other site 331271014432 Mg2+ binding site [ion binding]; other site 331271014433 G-X-G motif; other site 331271014434 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 331271014435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014436 active site 331271014437 phosphorylation site [posttranslational modification] 331271014438 intermolecular recognition site; other site 331271014439 dimerization interface [polypeptide binding]; other site 331271014440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271014441 DNA binding site [nucleotide binding] 331271014442 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 331271014443 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271014444 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 331271014445 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271014446 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331271014447 Phosphotransferase enzyme family; Region: APH; pfam01636 331271014448 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 331271014449 active site 331271014450 ATP binding site [chemical binding]; other site 331271014451 substrate binding site [chemical binding]; other site 331271014452 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 331271014453 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271014454 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271014455 N-terminal plug; other site 331271014456 ligand-binding site [chemical binding]; other site 331271014457 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 331271014458 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 331271014459 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 331271014460 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 331271014461 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 331271014462 FAD binding pocket [chemical binding]; other site 331271014463 FAD binding motif [chemical binding]; other site 331271014464 phosphate binding motif [ion binding]; other site 331271014465 beta-alpha-beta structure motif; other site 331271014466 NAD binding pocket [chemical binding]; other site 331271014467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271014468 catalytic loop [active] 331271014469 iron binding site [ion binding]; other site 331271014470 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 331271014471 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271014472 putative C-terminal domain interface [polypeptide binding]; other site 331271014473 putative GSH binding site (G-site) [chemical binding]; other site 331271014474 putative dimer interface [polypeptide binding]; other site 331271014475 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 331271014476 putative N-terminal domain interface [polypeptide binding]; other site 331271014477 putative dimer interface [polypeptide binding]; other site 331271014478 putative substrate binding pocket (H-site) [chemical binding]; other site 331271014479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014481 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271014482 putative effector binding pocket; other site 331271014483 dimerization interface [polypeptide binding]; other site 331271014484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271014485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271014486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271014487 short chain dehydrogenase; Provisional; Region: PRK05650 331271014488 NAD(P) binding site [chemical binding]; other site 331271014489 active site 331271014490 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 331271014491 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 331271014492 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271014493 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271014494 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 331271014495 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 331271014496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014497 putative substrate translocation pore; other site 331271014498 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271014499 Predicted flavoprotein [General function prediction only]; Region: COG0431 331271014500 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 331271014501 hypothetical protein; Provisional; Region: PRK09040 331271014502 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271014503 ligand binding site [chemical binding]; other site 331271014504 Domain of unknown function (DUF802); Region: DUF802; pfam05650 331271014505 Domain of unknown function (DUF802); Region: DUF802; pfam05650 331271014506 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 331271014507 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271014508 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331271014509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271014510 Coenzyme A binding pocket [chemical binding]; other site 331271014511 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271014512 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271014513 mercuric reductase; Validated; Region: PRK06370 331271014514 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271014515 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331271014516 transcriptional regulator; Provisional; Region: PRK10632 331271014517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014518 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271014519 putative effector binding pocket; other site 331271014520 putative dimerization interface [polypeptide binding]; other site 331271014521 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 331271014522 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271014523 putative NAD(P) binding site [chemical binding]; other site 331271014524 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 331271014525 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271014526 putative NAD(P) binding site [chemical binding]; other site 331271014527 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271014528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271014529 salt bridge; other site 331271014530 non-specific DNA binding site [nucleotide binding]; other site 331271014531 sequence-specific DNA binding site [nucleotide binding]; other site 331271014532 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 331271014533 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271014534 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271014535 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271014536 conserved cys residue [active] 331271014537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271014538 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 331271014539 SnoaL-like domain; Region: SnoaL_3; pfam13474 331271014540 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 331271014541 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 331271014542 conserved cys residue [active] 331271014543 short chain dehydrogenase; Provisional; Region: PRK06500 331271014544 classical (c) SDRs; Region: SDR_c; cd05233 331271014545 NAD(P) binding site [chemical binding]; other site 331271014546 active site 331271014547 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271014548 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271014549 dimerization interface [polypeptide binding]; other site 331271014550 putative Zn2+ binding site [ion binding]; other site 331271014551 putative DNA binding site [nucleotide binding]; other site 331271014552 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271014553 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 331271014554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271014555 Walker A/P-loop; other site 331271014556 ATP binding site [chemical binding]; other site 331271014557 Q-loop/lid; other site 331271014558 ABC transporter signature motif; other site 331271014559 Walker B; other site 331271014560 D-loop; other site 331271014561 H-loop/switch region; other site 331271014562 TOBE domain; Region: TOBE_2; pfam08402 331271014563 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 331271014564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271014565 dimer interface [polypeptide binding]; other site 331271014566 conserved gate region; other site 331271014567 putative PBP binding loops; other site 331271014568 ABC-ATPase subunit interface; other site 331271014569 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271014570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271014571 dimer interface [polypeptide binding]; other site 331271014572 conserved gate region; other site 331271014573 putative PBP binding loops; other site 331271014574 ABC-ATPase subunit interface; other site 331271014575 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 331271014576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 331271014577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271014578 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 331271014579 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271014580 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 331271014581 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 331271014582 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271014583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014584 putative substrate translocation pore; other site 331271014585 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271014586 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 331271014587 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271014588 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 331271014589 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 331271014590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271014592 putative substrate translocation pore; other site 331271014593 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271014594 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 331271014595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271014596 catalytic residue [active] 331271014597 Putative phosphatase (DUF442); Region: DUF442; cl17385 331271014598 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 331271014599 salt bridge; other site 331271014600 non-specific DNA binding site [nucleotide binding]; other site 331271014601 sequence-specific DNA binding site [nucleotide binding]; other site 331271014602 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 331271014603 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 331271014604 NAD(P) binding site [chemical binding]; other site 331271014605 DJ-1 family protein; Region: not_thiJ; TIGR01383 331271014606 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 331271014607 conserved cys residue [active] 331271014608 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271014609 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271014610 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271014611 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271014612 conserved cys residue [active] 331271014613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271014614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271014615 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 331271014616 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 331271014617 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 331271014618 generic binding surface I; other site 331271014619 generic binding surface II; other site 331271014620 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 331271014621 putative active site [active] 331271014622 putative catalytic site [active] 331271014623 putative Mg binding site IVb [ion binding]; other site 331271014624 putative phosphate binding site [ion binding]; other site 331271014625 putative DNA binding site [nucleotide binding]; other site 331271014626 putative Mg binding site IVa [ion binding]; other site 331271014627 CopC domain; Region: CopC; pfam04234 331271014628 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 331271014629 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 331271014630 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 331271014631 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 331271014632 Outer membrane efflux protein; Region: OEP; pfam02321 331271014633 Outer membrane efflux protein; Region: OEP; pfam02321 331271014634 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 331271014635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014636 active site 331271014637 phosphorylation site [posttranslational modification] 331271014638 intermolecular recognition site; other site 331271014639 dimerization interface [polypeptide binding]; other site 331271014640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271014641 DNA binding site [nucleotide binding] 331271014642 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 331271014643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271014644 dimerization interface [polypeptide binding]; other site 331271014645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271014646 dimer interface [polypeptide binding]; other site 331271014647 phosphorylation site [posttranslational modification] 331271014648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271014649 ATP binding site [chemical binding]; other site 331271014650 Mg2+ binding site [ion binding]; other site 331271014651 G-X-G motif; other site 331271014652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271014654 putative substrate translocation pore; other site 331271014655 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 331271014656 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 331271014657 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 331271014658 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 331271014659 putative metal binding site [ion binding]; other site 331271014660 putative homodimer interface [polypeptide binding]; other site 331271014661 putative homotetramer interface [polypeptide binding]; other site 331271014662 putative homodimer-homodimer interface [polypeptide binding]; other site 331271014663 putative allosteric switch controlling residues; other site 331271014664 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 331271014665 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 331271014666 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 331271014667 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 331271014668 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 331271014669 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 331271014670 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271014671 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 331271014672 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 331271014673 glutathionine S-transferase; Provisional; Region: PRK10542 331271014674 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 331271014675 C-terminal domain interface [polypeptide binding]; other site 331271014676 GSH binding site (G-site) [chemical binding]; other site 331271014677 dimer interface [polypeptide binding]; other site 331271014678 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 331271014679 dimer interface [polypeptide binding]; other site 331271014680 N-terminal domain interface [polypeptide binding]; other site 331271014681 substrate binding pocket (H-site) [chemical binding]; other site 331271014682 Predicted transcriptional regulators [Transcription]; Region: COG1733 331271014683 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 331271014684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014685 D-galactonate transporter; Region: 2A0114; TIGR00893 331271014686 putative substrate translocation pore; other site 331271014687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271014688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271014689 DNA binding residues [nucleotide binding] 331271014690 dimerization interface [polypeptide binding]; other site 331271014691 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271014692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271014693 Coenzyme A binding pocket [chemical binding]; other site 331271014694 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 331271014695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271014696 S-adenosylmethionine binding site [chemical binding]; other site 331271014697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014699 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 331271014700 putative dimerization interface [polypeptide binding]; other site 331271014701 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271014702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271014703 Coenzyme A binding pocket [chemical binding]; other site 331271014704 cyanate hydratase; Validated; Region: PRK02866 331271014705 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 331271014706 oligomer interface [polypeptide binding]; other site 331271014707 active site 331271014708 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 331271014709 active site clefts [active] 331271014710 zinc binding site [ion binding]; other site 331271014711 dimer interface [polypeptide binding]; other site 331271014712 Probable transposase; Region: OrfB_IS605; pfam01385 331271014713 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271014714 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271014715 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 331271014716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014717 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 331271014718 dimerization interface [polypeptide binding]; other site 331271014719 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 331271014720 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 331271014721 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014722 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014723 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271014724 dimerization interface [polypeptide binding]; other site 331271014725 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 331271014726 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 331271014727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271014728 pyruvate dehydrogenase; Provisional; Region: PRK09124 331271014729 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 331271014730 PYR/PP interface [polypeptide binding]; other site 331271014731 tetramer interface [polypeptide binding]; other site 331271014732 dimer interface [polypeptide binding]; other site 331271014733 TPP binding site [chemical binding]; other site 331271014734 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271014735 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 331271014736 TPP-binding site [chemical binding]; other site 331271014737 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271014738 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 331271014739 putative DNA binding site [nucleotide binding]; other site 331271014740 putative Zn2+ binding site [ion binding]; other site 331271014741 AsnC family; Region: AsnC_trans_reg; pfam01037 331271014742 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 331271014743 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 331271014744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271014745 catalytic residue [active] 331271014746 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 331271014747 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331271014748 Sel1-like repeats; Region: SEL1; smart00671 331271014749 BetR domain; Region: BetR; pfam08667 331271014750 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331271014751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014752 active site 331271014753 phosphorylation site [posttranslational modification] 331271014754 intermolecular recognition site; other site 331271014755 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 331271014756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271014757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271014758 dimer interface [polypeptide binding]; other site 331271014759 phosphorylation site [posttranslational modification] 331271014760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271014761 ATP binding site [chemical binding]; other site 331271014762 Mg2+ binding site [ion binding]; other site 331271014763 G-X-G motif; other site 331271014764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271014765 Response regulator receiver domain; Region: Response_reg; pfam00072 331271014766 active site 331271014767 phosphorylation site [posttranslational modification] 331271014768 intermolecular recognition site; other site 331271014769 dimerization interface [polypeptide binding]; other site 331271014770 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 331271014771 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331271014772 catalytic residues [active] 331271014773 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 331271014774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014775 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 331271014776 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 331271014777 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271014778 hypothetical protein; Provisional; Region: PRK11470 331271014779 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271014780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271014781 putative DNA binding site [nucleotide binding]; other site 331271014782 putative Zn2+ binding site [ion binding]; other site 331271014783 AsnC family; Region: AsnC_trans_reg; pfam01037 331271014784 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 331271014785 Predicted membrane protein [Function unknown]; Region: COG4541 331271014786 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 331271014787 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 331271014788 classical (c) SDRs; Region: SDR_c; cd05233 331271014789 NAD(P) binding site [chemical binding]; other site 331271014790 active site 331271014791 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 331271014792 putative active site [active] 331271014793 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 331271014794 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 331271014795 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 331271014796 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 331271014797 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 331271014798 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 331271014799 Cupin domain; Region: Cupin_2; cl17218 331271014800 allantoate amidohydrolase; Reviewed; Region: PRK12892 331271014801 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 331271014802 active site 331271014803 metal binding site [ion binding]; metal-binding site 331271014804 dimer interface [polypeptide binding]; other site 331271014805 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 331271014806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014807 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271014808 dimerization interface [polypeptide binding]; other site 331271014809 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271014810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271014811 catalytic residue [active] 331271014812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271014813 dimerization interface [polypeptide binding]; other site 331271014814 putative DNA binding site [nucleotide binding]; other site 331271014815 putative Zn2+ binding site [ion binding]; other site 331271014816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271014817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271014818 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271014819 putative effector binding pocket; other site 331271014820 dimerization interface [polypeptide binding]; other site 331271014821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271014822 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271014823 active site 331271014824 catalytic tetrad [active] 331271014825 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 331271014826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271014827 Walker A/P-loop; other site 331271014828 ATP binding site [chemical binding]; other site 331271014829 Q-loop/lid; other site 331271014830 ABC transporter signature motif; other site 331271014831 Walker B; other site 331271014832 D-loop; other site 331271014833 H-loop/switch region; other site 331271014834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271014835 Coenzyme A binding pocket [chemical binding]; other site 331271014836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271014837 non-specific DNA binding site [nucleotide binding]; other site 331271014838 salt bridge; other site 331271014839 sequence-specific DNA binding site [nucleotide binding]; other site 331271014840 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 331271014841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271014842 S-adenosylmethionine binding site [chemical binding]; other site 331271014843 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331271014844 oligomeric interface; other site 331271014845 putative active site [active] 331271014846 homodimer interface [polypeptide binding]; other site 331271014847 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 331271014848 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 331271014849 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 331271014850 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271014851 catalytic residues [active] 331271014852 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 331271014853 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 331271014854 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 331271014855 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 331271014856 active site 331271014857 metal binding site [ion binding]; metal-binding site 331271014858 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 331271014859 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 331271014860 Walker A motif; other site 331271014861 ATP binding site [chemical binding]; other site 331271014862 Walker B motif; other site 331271014863 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 331271014864 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 331271014865 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 331271014866 Walker A motif; other site 331271014867 hexamer interface [polypeptide binding]; other site 331271014868 ATP binding site [chemical binding]; other site 331271014869 Walker B motif; other site 331271014870 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 331271014871 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 331271014872 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 331271014873 VirB7 interaction site; other site 331271014874 VirB8 protein; Region: VirB8; pfam04335 331271014875 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 331271014876 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 331271014877 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 331271014878 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 331271014879 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331271014880 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331271014881 catalytic residue [active] 331271014882 Transposase; Region: HTH_Tnp_1; cl17663 331271014883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 331271014884 HTH-like domain; Region: HTH_21; pfam13276 331271014885 Integrase core domain; Region: rve; pfam00665 331271014886 Winged helix-turn helix; Region: HTH_29; pfam13551 331271014887 Helix-turn-helix domain; Region: HTH_28; pfam13518 331271014888 Homeodomain-like domain; Region: HTH_32; pfam13565 331271014889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 331271014890 Integrase core domain; Region: rve; pfam00665 331271014891 Integrase core domain; Region: rve_3; pfam13683 331271014892 putative transposase OrfB; Reviewed; Region: PHA02517 331271014893 HTH-like domain; Region: HTH_21; pfam13276 331271014894 Integrase core domain; Region: rve; pfam00665 331271014895 Integrase core domain; Region: rve_3; pfam13683 331271014896 Transposase; Region: HTH_Tnp_1; cl17663 331271014897 Transposase, Mutator family; Region: Transposase_mut; pfam00872 331271014898 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 331271014899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271014900 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271014901 Coenzyme A binding pocket [chemical binding]; other site 331271014902 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 331271014903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 331271014904 Integrase core domain; Region: rve; pfam00665 331271014905 Integrase core domain; Region: rve_3; pfam13683 331271014906 Transposase; Region: HTH_Tnp_1; pfam01527 331271014907 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 331271014908 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331271014909 Integrase core domain; Region: rve; pfam00665 331271014910 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331271014911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271014912 Walker A motif; other site 331271014913 ATP binding site [chemical binding]; other site 331271014914 Walker B motif; other site 331271014915 Homeodomain-like domain; Region: HTH_23; cl17451 331271014916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 331271014917 Integrase core domain; Region: rve; pfam00665 331271014918 Integrase core domain; Region: rve_3; pfam13683 331271014919 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271014920 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 331271014921 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271014922 YCII-related domain; Region: YCII; cl00999 331271014923 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 331271014924 sugar efflux transporter; Region: 2A0120; TIGR00899 331271014925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014926 putative substrate translocation pore; other site 331271014927 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 331271014928 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 331271014929 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 331271014930 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 331271014931 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271014932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271014933 dimer interface [polypeptide binding]; other site 331271014934 conserved gate region; other site 331271014935 putative PBP binding loops; other site 331271014936 ABC-ATPase subunit interface; other site 331271014937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271014938 dimer interface [polypeptide binding]; other site 331271014939 putative PBP binding loops; other site 331271014940 ABC-ATPase subunit interface; other site 331271014941 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 331271014942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 331271014943 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 331271014944 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 331271014945 Walker A/P-loop; other site 331271014946 ATP binding site [chemical binding]; other site 331271014947 Q-loop/lid; other site 331271014948 ABC transporter signature motif; other site 331271014949 Walker B; other site 331271014950 D-loop; other site 331271014951 H-loop/switch region; other site 331271014952 TOBE domain; Region: TOBE_2; pfam08402 331271014953 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271014954 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271014955 DNA binding site [nucleotide binding] 331271014956 domain linker motif; other site 331271014957 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 331271014958 dimerization interface [polypeptide binding]; other site 331271014959 ligand binding site [chemical binding]; other site 331271014960 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331271014961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271014962 Walker A motif; other site 331271014963 ATP binding site [chemical binding]; other site 331271014964 Walker B motif; other site 331271014965 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 331271014966 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271014967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271014968 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 331271014969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271014970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271014971 putative substrate translocation pore; other site 331271014972 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 331271014973 Amidase; Region: Amidase; cl11426 331271014974 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 331271014975 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271014976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331271014977 classical (c) SDRs; Region: SDR_c; cd05233 331271014978 NAD(P) binding site [chemical binding]; other site 331271014979 active site 331271014980 OsmC-like protein; Region: OsmC; pfam02566 331271014981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271014982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271014983 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 331271014984 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 331271014985 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 331271014986 catalytic residues [active] 331271014987 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271014988 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331271014989 FMN binding site [chemical binding]; other site 331271014990 active site 331271014991 substrate binding site [chemical binding]; other site 331271014992 catalytic residue [active] 331271014993 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 331271014994 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271014995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271014996 homodimer interface [polypeptide binding]; other site 331271014997 catalytic residue [active] 331271014998 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 331271014999 active site 1 [active] 331271015000 dimer interface [polypeptide binding]; other site 331271015001 hexamer interface [polypeptide binding]; other site 331271015002 active site 2 [active] 331271015003 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 331271015004 Bacterial TniB protein; Region: TniB; pfam05621 331271015005 AAA domain; Region: AAA_22; pfam13401 331271015006 Winged helix-turn helix; Region: HTH_29; pfam13551 331271015007 Integrase core domain; Region: rve; pfam00665 331271015008 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 331271015009 Flavin Reductases; Region: FlaRed; cl00801 331271015010 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 331271015011 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271015012 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 331271015013 acyl-activating enzyme (AAE) consensus motif; other site 331271015014 putative AMP binding site [chemical binding]; other site 331271015015 putative active site [active] 331271015016 putative CoA binding site [chemical binding]; other site 331271015017 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 331271015018 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271015019 substrate binding site [chemical binding]; other site 331271015020 oxyanion hole (OAH) forming residues; other site 331271015021 trimer interface [polypeptide binding]; other site 331271015022 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 331271015023 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 331271015024 Creatinine amidohydrolase; Region: Creatininase; pfam02633 331271015025 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 331271015026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271015027 substrate binding site [chemical binding]; other site 331271015028 oxyanion hole (OAH) forming residues; other site 331271015029 trimer interface [polypeptide binding]; other site 331271015030 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271015031 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271015032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015033 acyl-CoA synthetase; Validated; Region: PRK08162 331271015034 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 331271015035 acyl-activating enzyme (AAE) consensus motif; other site 331271015036 putative active site [active] 331271015037 AMP binding site [chemical binding]; other site 331271015038 putative CoA binding site [chemical binding]; other site 331271015039 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 331271015040 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 331271015041 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 331271015042 dimerization interface [polypeptide binding]; other site 331271015043 active site 331271015044 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271015045 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271015046 putative DNA binding site [nucleotide binding]; other site 331271015047 putative Zn2+ binding site [ion binding]; other site 331271015048 AsnC family; Region: AsnC_trans_reg; pfam01037 331271015049 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271015050 E3 interaction surface; other site 331271015051 lipoyl attachment site [posttranslational modification]; other site 331271015052 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 331271015053 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271015054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271015055 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331271015056 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271015057 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 331271015058 E3 interaction surface; other site 331271015059 lipoyl attachment site [posttranslational modification]; other site 331271015060 e3 binding domain; Region: E3_binding; pfam02817 331271015061 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 331271015062 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 331271015063 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 331271015064 dimer interface [polypeptide binding]; other site 331271015065 TPP-binding site [chemical binding]; other site 331271015066 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 331271015067 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271015068 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271015069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015070 benzoate transport; Region: 2A0115; TIGR00895 331271015071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015072 putative substrate translocation pore; other site 331271015073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015074 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271015075 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271015076 trimer interface [polypeptide binding]; other site 331271015077 eyelet of channel; other site 331271015078 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271015079 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 331271015080 Protein of unknown function, DUF488; Region: DUF488; pfam04343 331271015081 hypothetical protein; Provisional; Region: PRK10621 331271015082 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331271015083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 331271015084 Transposase; Region: HTH_Tnp_1; pfam01527 331271015085 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271015086 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271015087 trimer interface [polypeptide binding]; other site 331271015088 eyelet of channel; other site 331271015089 benzoate transport; Region: 2A0115; TIGR00895 331271015090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015091 putative substrate translocation pore; other site 331271015092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015093 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271015094 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271015095 inhibitor site; inhibition site 331271015096 active site 331271015097 dimer interface [polypeptide binding]; other site 331271015098 catalytic residue [active] 331271015099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271015102 dimerization interface [polypeptide binding]; other site 331271015103 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271015104 Pirin-related protein [General function prediction only]; Region: COG1741 331271015105 Pirin; Region: Pirin; pfam02678 331271015106 short chain dehydrogenase; Provisional; Region: PRK06500 331271015107 classical (c) SDRs; Region: SDR_c; cd05233 331271015108 NAD(P) binding site [chemical binding]; other site 331271015109 active site 331271015110 LysR family transcriptional regulator; Provisional; Region: PRK14997 331271015111 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015112 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271015113 putative effector binding pocket; other site 331271015114 dimerization interface [polypeptide binding]; other site 331271015115 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271015116 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271015117 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271015118 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271015119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015120 short chain dehydrogenase; Provisional; Region: PRK06179 331271015121 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271015122 NADP binding site [chemical binding]; other site 331271015123 active site 331271015124 steroid binding site; other site 331271015125 YCII-related domain; Region: YCII; pfam03795 331271015126 short chain dehydrogenase; Validated; Region: PRK08264 331271015127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271015128 NAD(P) binding site [chemical binding]; other site 331271015129 active site 331271015130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015131 D-galactonate transporter; Region: 2A0114; TIGR00893 331271015132 putative substrate translocation pore; other site 331271015133 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 331271015134 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 331271015135 active site pocket [active] 331271015136 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 331271015137 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 331271015138 dimerization interface [polypeptide binding]; other site 331271015139 ligand binding site [chemical binding]; other site 331271015140 NADP binding site [chemical binding]; other site 331271015141 catalytic site [active] 331271015142 classical (c) SDRs; Region: SDR_c; cd05233 331271015143 NAD(P) binding site [chemical binding]; other site 331271015144 active site 331271015145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015146 D-galactonate transporter; Region: 2A0114; TIGR00893 331271015147 putative substrate translocation pore; other site 331271015148 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271015149 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 331271015150 active site 331271015151 metal binding site [ion binding]; metal-binding site 331271015152 Helix-turn-helix domain; Region: HTH_17; pfam12728 331271015153 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 331271015154 active site 331271015155 coenzyme A binding site [chemical binding]; other site 331271015156 citrylCoA binding site [chemical binding]; other site 331271015157 dimer interface [polypeptide binding]; other site 331271015158 Citrate synthase; Region: Citrate_synt; pfam00285 331271015159 oxalacetate/citrate binding site [chemical binding]; other site 331271015160 catalytic triad [active] 331271015161 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271015162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015163 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271015164 dimerization interface [polypeptide binding]; other site 331271015165 substrate binding pocket [chemical binding]; other site 331271015166 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 331271015167 EamA-like transporter family; Region: EamA; pfam00892 331271015168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271015169 NAD(P) binding site [chemical binding]; other site 331271015170 active site 331271015171 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331271015172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271015173 Walker A motif; other site 331271015174 ATP binding site [chemical binding]; other site 331271015175 Walker B motif; other site 331271015176 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 331271015177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331271015178 Integrase core domain; Region: rve; pfam00665 331271015179 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 331271015180 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 331271015181 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 331271015182 active site 331271015183 zinc binding site [ion binding]; other site 331271015184 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 331271015185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271015186 active site 331271015187 phosphorylation site [posttranslational modification] 331271015188 intermolecular recognition site; other site 331271015189 dimerization interface [polypeptide binding]; other site 331271015190 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271015191 DNA binding residues [nucleotide binding] 331271015192 dimerization interface [polypeptide binding]; other site 331271015193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271015194 dimer interface [polypeptide binding]; other site 331271015195 phosphorylation site [posttranslational modification] 331271015196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271015197 ATP binding site [chemical binding]; other site 331271015198 Mg2+ binding site [ion binding]; other site 331271015199 G-X-G motif; other site 331271015200 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 331271015201 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271015202 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 331271015203 Sodium Bile acid symporter family; Region: SBF; cl17470 331271015204 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 331271015205 Low molecular weight phosphatase family; Region: LMWPc; cd00115 331271015206 active site 331271015207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271015208 dimerization interface [polypeptide binding]; other site 331271015209 putative DNA binding site [nucleotide binding]; other site 331271015210 putative Zn2+ binding site [ion binding]; other site 331271015211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015212 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271015213 putative substrate translocation pore; other site 331271015214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271015216 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 331271015217 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271015218 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 331271015219 Cupin domain; Region: Cupin_2; pfam07883 331271015220 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271015221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015224 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271015225 putative effector binding pocket; other site 331271015226 dimerization interface [polypeptide binding]; other site 331271015227 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 331271015228 putative hydrophobic ligand binding site [chemical binding]; other site 331271015229 protein interface [polypeptide binding]; other site 331271015230 gate; other site 331271015231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 331271015232 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 331271015233 acyl-activating enzyme (AAE) consensus motif; other site 331271015234 AMP binding site [chemical binding]; other site 331271015235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 331271015236 thioester reductase domain; Region: Thioester-redct; TIGR01746 331271015237 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 331271015238 putative NAD(P) binding site [chemical binding]; other site 331271015239 active site 331271015240 putative substrate binding site [chemical binding]; other site 331271015241 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 331271015242 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 331271015243 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 331271015244 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 331271015245 hypothetical protein; Provisional; Region: PRK07481 331271015246 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271015247 inhibitor-cofactor binding pocket; inhibition site 331271015248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271015249 catalytic residue [active] 331271015250 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271015251 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271015252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015253 Autoinducer binding domain; Region: Autoind_bind; pfam03472 331271015254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271015255 DNA binding residues [nucleotide binding] 331271015256 dimerization interface [polypeptide binding]; other site 331271015257 2-isopropylmalate synthase; Validated; Region: PRK03739 331271015258 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 331271015259 active site 331271015260 catalytic residues [active] 331271015261 metal binding site [ion binding]; metal-binding site 331271015262 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 331271015263 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 331271015264 N-Terminal Domain Of Bc2l-C Lectin; Region: Bc2l-C_N; cd12211 331271015265 trimer interface [polypeptide binding]; other site 331271015266 ligand binding site [chemical binding]; other site 331271015267 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 331271015268 Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472 331271015269 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 331271015270 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 331271015271 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 331271015272 Autotransporter beta-domain; Region: Autotransporter; smart00869 331271015273 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 331271015274 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 331271015275 putative heme binding pocket [chemical binding]; other site 331271015276 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 331271015277 Peptidase family M23; Region: Peptidase_M23; pfam01551 331271015278 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331271015279 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271015280 malate:quinone oxidoreductase; Validated; Region: PRK05257 331271015281 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 331271015282 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 331271015283 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331271015284 ATP binding site [chemical binding]; other site 331271015285 Mg++ binding site [ion binding]; other site 331271015286 motif III; other site 331271015287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271015288 nucleotide binding region [chemical binding]; other site 331271015289 ATP-binding site [chemical binding]; other site 331271015290 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 331271015291 putative RNA binding site [nucleotide binding]; other site 331271015292 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 331271015293 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 331271015294 Fatty acid desaturase; Region: FA_desaturase; pfam00487 331271015295 putative di-iron ligands [ion binding]; other site 331271015296 benzoate transporter; Region: benE; TIGR00843 331271015297 Benzoate membrane transport protein; Region: BenE; pfam03594 331271015298 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271015299 ligand binding site [chemical binding]; other site 331271015300 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 331271015301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271015302 NAD(P) binding site [chemical binding]; other site 331271015303 active site 331271015304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271015306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015309 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 331271015310 putative dimerization interface [polypeptide binding]; other site 331271015311 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331271015312 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271015313 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271015314 pyrophosphatase PpaX; Provisional; Region: PRK13288 331271015315 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 331271015316 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 331271015317 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 331271015318 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 331271015319 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 331271015320 DNA polymerase II; Reviewed; Region: PRK05762 331271015321 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 331271015322 active site 331271015323 catalytic site [active] 331271015324 substrate binding site [chemical binding]; other site 331271015325 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 331271015326 active site 331271015327 metal-binding site 331271015328 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271015329 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 331271015330 HSP70 interaction site [polypeptide binding]; other site 331271015331 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 331271015332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015333 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 331271015334 substrate binding pocket [chemical binding]; other site 331271015335 dimerization interface [polypeptide binding]; other site 331271015336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271015337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271015338 active site 331271015339 short chain dehydrogenase; Provisional; Region: PRK06172 331271015340 classical (c) SDRs; Region: SDR_c; cd05233 331271015341 NAD(P) binding site [chemical binding]; other site 331271015342 active site 331271015343 short chain dehydrogenase; Provisional; Region: PRK07035 331271015344 classical (c) SDRs; Region: SDR_c; cd05233 331271015345 NAD(P) binding site [chemical binding]; other site 331271015346 active site 331271015347 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 331271015348 Phosphotransferase enzyme family; Region: APH; pfam01636 331271015349 putative active site [active] 331271015350 putative substrate binding site [chemical binding]; other site 331271015351 ATP binding site [chemical binding]; other site 331271015352 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331271015353 catalytic core [active] 331271015354 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 331271015355 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 331271015356 BON domain; Region: BON; pfam04972 331271015357 transcriptional regulator; Provisional; Region: PRK10632 331271015358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015359 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271015360 putative effector binding pocket; other site 331271015361 dimerization interface [polypeptide binding]; other site 331271015362 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 331271015363 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 331271015364 NAD(P) binding site [chemical binding]; other site 331271015365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271015368 dimerization interface [polypeptide binding]; other site 331271015369 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 331271015370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271015371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271015372 DNA binding residues [nucleotide binding] 331271015373 dimerization interface [polypeptide binding]; other site 331271015374 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 331271015375 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271015376 acyl-activating enzyme (AAE) consensus motif; other site 331271015377 AMP binding site [chemical binding]; other site 331271015378 active site 331271015379 CoA binding site [chemical binding]; other site 331271015380 chaperone protein HchA; Provisional; Region: PRK04155 331271015381 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 331271015382 conserved cys residue [active] 331271015383 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271015384 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271015385 active site 331271015386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271015387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271015388 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 331271015389 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271015390 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271015391 lipid-transfer protein; Provisional; Region: PRK08256 331271015392 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 331271015393 active site 331271015394 acyl-CoA synthetase; Validated; Region: PRK06188 331271015395 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271015396 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 331271015397 acyl-activating enzyme (AAE) consensus motif; other site 331271015398 acyl-activating enzyme (AAE) consensus motif; other site 331271015399 putative AMP binding site [chemical binding]; other site 331271015400 putative active site [active] 331271015401 putative CoA binding site [chemical binding]; other site 331271015402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271015403 NAD(P) binding site [chemical binding]; other site 331271015404 Cytochrome c; Region: Cytochrom_C; cl11414 331271015405 Cytochrome c; Region: Cytochrom_C; cl11414 331271015406 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 331271015407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271015408 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 331271015409 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 331271015410 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 331271015411 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 331271015412 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 331271015413 homotrimer interaction site [polypeptide binding]; other site 331271015414 putative active site [active] 331271015415 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 331271015416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271015417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271015418 Cytochrome c; Region: Cytochrom_C; cl11414 331271015419 Cytochrome c; Region: Cytochrom_C; cl11414 331271015420 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 331271015421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271015422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271015423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271015424 active site 331271015425 phosphorylation site [posttranslational modification] 331271015426 intermolecular recognition site; other site 331271015427 dimerization interface [polypeptide binding]; other site 331271015428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271015429 DNA binding site [nucleotide binding] 331271015430 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271015431 HAMP domain; Region: HAMP; pfam00672 331271015432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271015433 dimer interface [polypeptide binding]; other site 331271015434 phosphorylation site [posttranslational modification] 331271015435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271015436 Mg2+ binding site [ion binding]; other site 331271015437 G-X-G motif; other site 331271015438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015439 D-galactonate transporter; Region: 2A0114; TIGR00893 331271015440 putative substrate translocation pore; other site 331271015441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271015444 dimerization interface [polypeptide binding]; other site 331271015445 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 331271015446 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 331271015447 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 331271015448 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 331271015449 putative active site pocket [active] 331271015450 putative metal binding site [ion binding]; other site 331271015451 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271015452 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271015453 inhibitor site; inhibition site 331271015454 active site 331271015455 dimer interface [polypeptide binding]; other site 331271015456 catalytic residue [active] 331271015457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015458 D-galactonate transporter; Region: 2A0114; TIGR00893 331271015459 putative substrate translocation pore; other site 331271015460 Uncharacterized conserved protein [Function unknown]; Region: COG3391 331271015461 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271015462 Amidohydrolase; Region: Amidohydro_2; pfam04909 331271015463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 331271015464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 331271015465 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 331271015466 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 331271015467 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271015468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271015469 dimer interface [polypeptide binding]; other site 331271015470 conserved gate region; other site 331271015471 putative PBP binding loops; other site 331271015472 ABC-ATPase subunit interface; other site 331271015473 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331271015474 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 331271015475 inhibitor binding site; inhibition site 331271015476 catalytic Zn binding site [ion binding]; other site 331271015477 structural Zn binding site [ion binding]; other site 331271015478 NADP binding site [chemical binding]; other site 331271015479 tetramer interface [polypeptide binding]; other site 331271015480 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 331271015481 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 331271015482 Walker A/P-loop; other site 331271015483 ATP binding site [chemical binding]; other site 331271015484 Q-loop/lid; other site 331271015485 ABC transporter signature motif; other site 331271015486 Walker B; other site 331271015487 D-loop; other site 331271015488 H-loop/switch region; other site 331271015489 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271015490 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271015491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015492 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 331271015493 N- and C-terminal domain interface [polypeptide binding]; other site 331271015494 D-xylulose kinase; Region: XylB; TIGR01312 331271015495 active site 331271015496 MgATP binding site [chemical binding]; other site 331271015497 catalytic site [active] 331271015498 metal binding site [ion binding]; metal-binding site 331271015499 xylulose binding site [chemical binding]; other site 331271015500 homodimer interface [polypeptide binding]; other site 331271015501 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 331271015502 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 331271015503 DNA binding residues [nucleotide binding] 331271015504 dimer interface [polypeptide binding]; other site 331271015505 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 331271015506 putative RNAase interaction site [polypeptide binding]; other site 331271015507 Esterase/lipase [General function prediction only]; Region: COG1647 331271015508 MASE1; Region: MASE1; pfam05231 331271015509 PAS fold; Region: PAS_3; pfam08447 331271015510 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271015511 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271015512 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 331271015513 SurA N-terminal domain; Region: SurA_N_3; cl07813 331271015514 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 331271015515 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 331271015516 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271015517 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 331271015518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271015519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271015520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271015521 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 331271015522 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 331271015523 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 331271015524 putative active site [active] 331271015525 putative metal binding site [ion binding]; other site 331271015526 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 331271015527 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 331271015528 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 331271015529 AMP-binding domain protein; Validated; Region: PRK07529 331271015530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271015531 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 331271015532 acyl-activating enzyme (AAE) consensus motif; other site 331271015533 putative AMP binding site [chemical binding]; other site 331271015534 putative active site [active] 331271015535 putative CoA binding site [chemical binding]; other site 331271015536 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331271015537 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271015538 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 331271015539 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 331271015540 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 331271015541 putative active site [active] 331271015542 putative metal binding site [ion binding]; other site 331271015543 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 331271015544 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271015545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271015546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271015547 H+ Antiporter protein; Region: 2A0121; TIGR00900 331271015548 Biofilm formation and stress response factor; Region: BsmA; pfam10014 331271015549 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 331271015550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271015551 Radical SAM superfamily; Region: Radical_SAM; pfam04055 331271015552 FeS/SAM binding site; other site 331271015553 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 331271015554 rRNA binding site [nucleotide binding]; other site 331271015555 predicted 30S ribosome binding site; other site 331271015556 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 331271015557 DNA-binding site [nucleotide binding]; DNA binding site 331271015558 RNA-binding motif; other site 331271015559 Winged helix-turn helix; Region: HTH_29; pfam13551 331271015560 Helix-turn-helix domain; Region: HTH_28; pfam13518 331271015561 Homeodomain-like domain; Region: HTH_32; pfam13565 331271015562 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 331271015563 Integrase core domain; Region: rve; pfam00665 331271015564 Integrase core domain; Region: rve_3; pfam13683 331271015565 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271015566 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271015567 ligand binding site [chemical binding]; other site 331271015568 flexible hinge region; other site 331271015569 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 331271015570 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 331271015571 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271015572 benzoate transport; Region: 2A0115; TIGR00895 331271015573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015574 putative substrate translocation pore; other site 331271015575 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 331271015576 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 331271015577 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 331271015578 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 331271015579 tetramer interface [polypeptide binding]; other site 331271015580 active site 331271015581 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 331271015582 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 331271015583 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 331271015584 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271015585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015587 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 331271015588 substrate binding pocket [chemical binding]; other site 331271015589 dimerization interface [polypeptide binding]; other site 331271015590 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 331271015591 GTP cyclohydrolase I; Provisional; Region: PLN03044 331271015592 active site 331271015593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271015594 short chain dehydrogenase; Provisional; Region: PRK09134 331271015595 NAD(P) binding site [chemical binding]; other site 331271015596 active site 331271015597 serine O-acetyltransferase; Region: cysE; TIGR01172 331271015598 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 331271015599 trimer interface [polypeptide binding]; other site 331271015600 active site 331271015601 substrate binding site [chemical binding]; other site 331271015602 CoA binding site [chemical binding]; other site 331271015603 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 331271015604 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271015605 Ligand Binding Site [chemical binding]; other site 331271015606 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 331271015607 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271015608 ligand binding site [chemical binding]; other site 331271015609 flexible hinge region; other site 331271015610 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 331271015611 putative switch regulator; other site 331271015612 non-specific DNA interactions [nucleotide binding]; other site 331271015613 DNA binding site [nucleotide binding] 331271015614 sequence specific DNA binding site [nucleotide binding]; other site 331271015615 putative cAMP binding site [chemical binding]; other site 331271015616 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 331271015617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271015619 dimerization interface [polypeptide binding]; other site 331271015620 Lysine efflux permease [General function prediction only]; Region: COG1279 331271015621 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 331271015622 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 331271015623 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 331271015624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 331271015625 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 331271015626 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 331271015627 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 331271015628 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 331271015629 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271015630 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271015631 active site 331271015632 catalytic tetrad [active] 331271015633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271015634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271015635 Cupin domain; Region: Cupin_2; pfam07883 331271015636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015637 D-galactonate transporter; Region: 2A0114; TIGR00893 331271015638 putative substrate translocation pore; other site 331271015639 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331271015640 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 331271015641 putative NAD(P) binding site [chemical binding]; other site 331271015642 catalytic Zn binding site [ion binding]; other site 331271015643 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331271015644 classical (c) SDRs; Region: SDR_c; cd05233 331271015645 NAD(P) binding site [chemical binding]; other site 331271015646 active site 331271015647 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271015648 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271015649 trimer interface [polypeptide binding]; other site 331271015650 eyelet of channel; other site 331271015651 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 331271015652 YcaO-like family; Region: YcaO; pfam02624 331271015653 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 331271015654 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 331271015655 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 331271015656 Catalytic domain of Protein Kinases; Region: PKc; cd00180 331271015657 active site 331271015658 ATP binding site [chemical binding]; other site 331271015659 substrate binding site [chemical binding]; other site 331271015660 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 331271015661 activation loop (A-loop); other site 331271015662 cyclase homology domain; Region: CHD; cd07302 331271015663 nucleotidyl binding site; other site 331271015664 metal binding site [ion binding]; metal-binding site 331271015665 AAA ATPase domain; Region: AAA_16; pfam13191 331271015666 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 331271015667 phosphopeptide binding site; other site 331271015668 Predicted transcriptional regulators [Transcription]; Region: COG1695 331271015669 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 331271015670 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 331271015671 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 331271015672 FAD binding pocket [chemical binding]; other site 331271015673 FAD binding motif [chemical binding]; other site 331271015674 phosphate binding motif [ion binding]; other site 331271015675 NAD binding pocket [chemical binding]; other site 331271015676 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 331271015677 active site 331271015678 acetoacetate decarboxylase; Provisional; Region: PRK02265 331271015679 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 331271015680 classical (c) SDRs; Region: SDR_c; cd05233 331271015681 NAD(P) binding site [chemical binding]; other site 331271015682 active site 331271015683 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 331271015684 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 331271015685 nucleophile elbow; other site 331271015686 Patatin phospholipase; Region: DUF3734; pfam12536 331271015687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271015690 dimerization interface [polypeptide binding]; other site 331271015691 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 331271015692 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 331271015693 transcriptional activator TtdR; Provisional; Region: PRK09801 331271015694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015695 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 331271015696 putative effector binding pocket; other site 331271015697 putative dimerization interface [polypeptide binding]; other site 331271015698 tartrate dehydrogenase; Region: TTC; TIGR02089 331271015699 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 331271015700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 331271015701 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271015702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271015703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271015704 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 331271015705 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 331271015706 NAD(P) binding site [chemical binding]; other site 331271015707 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 331271015708 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 331271015709 substrate-cofactor binding pocket; other site 331271015710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271015711 catalytic residue [active] 331271015712 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271015713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271015714 non-specific DNA binding site [nucleotide binding]; other site 331271015715 salt bridge; other site 331271015716 sequence-specific DNA binding site [nucleotide binding]; other site 331271015717 Cupin domain; Region: Cupin_2; pfam07883 331271015718 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 331271015719 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 331271015720 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 331271015721 active site 331271015722 catalytic residues [active] 331271015723 Int/Topo IB signature motif; other site 331271015724 DNA binding site [nucleotide binding] 331271015725 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 331271015726 Initiator Replication protein; Region: Rep_3; pfam01051 331271015727 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 331271015728 ParB-like nuclease domain; Region: ParB; smart00470 331271015729 ParA-like protein; Provisional; Region: PHA02518 331271015730 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271015731 P-loop; other site 331271015732 Magnesium ion binding site [ion binding]; other site 331271015733 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 331271015734 ArsC family; Region: ArsC; pfam03960 331271015735 catalytic residues [active] 331271015736 Putative zinc-finger; Region: zf-HC2; pfam13490 331271015737 RNA polymerase sigma factor; Provisional; Region: PRK12545 331271015738 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 331271015739 DNA binding residues [nucleotide binding] 331271015740 Predicted flavoprotein [General function prediction only]; Region: COG0431 331271015741 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271015742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271015743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271015744 dimer interface [polypeptide binding]; other site 331271015745 phosphorylation site [posttranslational modification] 331271015746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271015747 ATP binding site [chemical binding]; other site 331271015748 Mg2+ binding site [ion binding]; other site 331271015749 G-X-G motif; other site 331271015750 Response regulator receiver domain; Region: Response_reg; pfam00072 331271015751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271015752 active site 331271015753 phosphorylation site [posttranslational modification] 331271015754 intermolecular recognition site; other site 331271015755 dimerization interface [polypeptide binding]; other site 331271015756 Response regulator receiver domain; Region: Response_reg; pfam00072 331271015757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271015758 active site 331271015759 phosphorylation site [posttranslational modification] 331271015760 intermolecular recognition site; other site 331271015761 dimerization interface [polypeptide binding]; other site 331271015762 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 331271015763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271015764 PAS domain; Region: PAS_9; pfam13426 331271015765 putative active site [active] 331271015766 heme pocket [chemical binding]; other site 331271015767 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 331271015768 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271015769 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271015770 metal binding site [ion binding]; metal-binding site 331271015771 active site 331271015772 I-site; other site 331271015773 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 331271015774 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271015775 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 331271015776 active site lid residues [active] 331271015777 substrate binding pocket [chemical binding]; other site 331271015778 catalytic residues [active] 331271015779 substrate-Mg2+ binding site; other site 331271015780 aspartate-rich region 1; other site 331271015781 aspartate-rich region 2; other site 331271015782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331271015783 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 331271015784 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 331271015785 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 331271015786 Active site cavity [active] 331271015787 catalytic acid [active] 331271015788 hypothetical protein; Provisional; Region: PRK07077 331271015789 VacJ like lipoprotein; Region: VacJ; cl01073 331271015790 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 331271015791 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 331271015792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271015793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271015794 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271015795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015796 putative substrate translocation pore; other site 331271015797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271015798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271015799 active site 331271015800 phosphorylation site [posttranslational modification] 331271015801 intermolecular recognition site; other site 331271015802 dimerization interface [polypeptide binding]; other site 331271015803 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271015804 DNA binding residues [nucleotide binding] 331271015805 dimerization interface [polypeptide binding]; other site 331271015806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 331271015807 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 331271015808 Histidine kinase; Region: HisKA_3; pfam07730 331271015809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271015810 ATP binding site [chemical binding]; other site 331271015811 Mg2+ binding site [ion binding]; other site 331271015812 G-X-G motif; other site 331271015813 Cache domain; Region: Cache_1; pfam02743 331271015814 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271015815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271015816 metal binding site [ion binding]; metal-binding site 331271015817 active site 331271015818 I-site; other site 331271015819 malate synthase G; Provisional; Region: PRK02999 331271015820 active site 331271015821 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 331271015822 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 331271015823 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331271015824 ATP binding site [chemical binding]; other site 331271015825 Mg++ binding site [ion binding]; other site 331271015826 motif III; other site 331271015827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271015828 nucleotide binding region [chemical binding]; other site 331271015829 ATP-binding site [chemical binding]; other site 331271015830 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271015831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015832 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271015833 dimerization interface [polypeptide binding]; other site 331271015834 substrate binding pocket [chemical binding]; other site 331271015835 SnoaL-like domain; Region: SnoaL_2; pfam12680 331271015836 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 331271015837 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331271015838 EamA-like transporter family; Region: EamA; pfam00892 331271015839 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 331271015840 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 331271015841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271015842 dimer interface [polypeptide binding]; other site 331271015843 conserved gate region; other site 331271015844 putative PBP binding loops; other site 331271015845 ABC-ATPase subunit interface; other site 331271015846 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271015847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271015848 dimer interface [polypeptide binding]; other site 331271015849 conserved gate region; other site 331271015850 putative PBP binding loops; other site 331271015851 ABC-ATPase subunit interface; other site 331271015852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 331271015853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 331271015854 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 331271015855 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 331271015856 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 331271015857 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 331271015858 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 331271015859 Walker A/P-loop; other site 331271015860 ATP binding site [chemical binding]; other site 331271015861 Q-loop/lid; other site 331271015862 ABC transporter signature motif; other site 331271015863 Walker B; other site 331271015864 D-loop; other site 331271015865 H-loop/switch region; other site 331271015866 TOBE domain; Region: TOBE_2; pfam08402 331271015867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271015868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271015869 DNA binding site [nucleotide binding] 331271015870 domain linker motif; other site 331271015871 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 331271015872 dimerization interface [polypeptide binding]; other site 331271015873 ligand binding site [chemical binding]; other site 331271015874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271015875 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271015876 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 331271015877 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 331271015878 beta-galactosidase; Region: BGL; TIGR03356 331271015879 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 331271015880 Uncharacterized conserved protein [Function unknown]; Region: COG1262 331271015881 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 331271015882 Sulfatase; Region: Sulfatase; pfam00884 331271015883 Sulfatase; Region: Sulfatase; cl17466 331271015884 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271015885 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271015886 eyelet of channel; other site 331271015887 trimer interface [polypeptide binding]; other site 331271015888 BON domain; Region: BON; pfam04972 331271015889 Transcriptional regulators [Transcription]; Region: GntR; COG1802 331271015890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271015891 DNA-binding site [nucleotide binding]; DNA binding site 331271015892 FCD domain; Region: FCD; pfam07729 331271015893 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 331271015894 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 331271015895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271015897 dimerization interface [polypeptide binding]; other site 331271015898 dihydroxy-acid dehydratase; Validated; Region: PRK06131 331271015899 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271015900 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271015901 inhibitor site; inhibition site 331271015902 active site 331271015903 dimer interface [polypeptide binding]; other site 331271015904 catalytic residue [active] 331271015905 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 331271015906 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 331271015907 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 331271015908 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 331271015909 ligand binding site [chemical binding]; other site 331271015910 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 331271015911 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271015912 Walker A/P-loop; other site 331271015913 ATP binding site [chemical binding]; other site 331271015914 Q-loop/lid; other site 331271015915 ABC transporter signature motif; other site 331271015916 Walker B; other site 331271015917 D-loop; other site 331271015918 H-loop/switch region; other site 331271015919 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271015920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271015921 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271015922 TM-ABC transporter signature motif; other site 331271015923 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 331271015924 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331271015925 MarR family; Region: MarR_2; pfam12802 331271015926 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 331271015927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271015928 substrate binding site [chemical binding]; other site 331271015929 oxyanion hole (OAH) forming residues; other site 331271015930 trimer interface [polypeptide binding]; other site 331271015931 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271015932 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 331271015933 NAD(P) binding site [chemical binding]; other site 331271015934 catalytic residues [active] 331271015935 feruloyl-CoA synthase; Reviewed; Region: PRK08180 331271015936 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 331271015937 acyl-activating enzyme (AAE) consensus motif; other site 331271015938 putative AMP binding site [chemical binding]; other site 331271015939 putative active site [active] 331271015940 putative CoA binding site [chemical binding]; other site 331271015941 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 331271015942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271015943 putative substrate translocation pore; other site 331271015944 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271015945 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271015946 trimer interface [polypeptide binding]; other site 331271015947 eyelet of channel; other site 331271015948 Tannase and feruloyl esterase; Region: Tannase; pfam07519 331271015949 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271015950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271015951 putative DNA binding site [nucleotide binding]; other site 331271015952 putative Zn2+ binding site [ion binding]; other site 331271015953 AsnC family; Region: AsnC_trans_reg; pfam01037 331271015954 diaminopropionate ammonia-lyase; Provisional; Region: PRK08206 331271015955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271015956 catalytic residue [active] 331271015957 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331271015958 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 331271015959 metal binding site [ion binding]; metal-binding site 331271015960 putative dimer interface [polypeptide binding]; other site 331271015961 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 331271015962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271015963 Coenzyme A binding pocket [chemical binding]; other site 331271015964 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 331271015965 cytosine deaminase; Provisional; Region: PRK05985 331271015966 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 331271015967 active site 331271015968 cytosine deaminase; Provisional; Region: PRK05985 331271015969 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 331271015970 active site 331271015971 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 331271015972 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271015973 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271015974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271015975 dimerization interface [polypeptide binding]; other site 331271015976 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 331271015977 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271015978 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271015979 non-specific DNA binding site [nucleotide binding]; other site 331271015980 salt bridge; other site 331271015981 sequence-specific DNA binding site [nucleotide binding]; other site 331271015982 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 331271015983 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271015984 substrate binding pocket [chemical binding]; other site 331271015985 membrane-bound complex binding site; other site 331271015986 hinge residues; other site 331271015987 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 331271015988 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 331271015989 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271015990 DNA-binding site [nucleotide binding]; DNA binding site 331271015991 UTRA domain; Region: UTRA; pfam07702 331271015992 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331271015993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271015994 non-specific DNA binding site [nucleotide binding]; other site 331271015995 salt bridge; other site 331271015996 sequence-specific DNA binding site [nucleotide binding]; other site 331271015997 Cupin domain; Region: Cupin_2; pfam07883 331271015998 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 331271015999 intersubunit interface [polypeptide binding]; other site 331271016000 active site 331271016001 Zn2+ binding site [ion binding]; other site 331271016002 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271016003 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271016004 inhibitor site; inhibition site 331271016005 active site 331271016006 dimer interface [polypeptide binding]; other site 331271016007 catalytic residue [active] 331271016008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 331271016009 MOSC domain; Region: MOSC; pfam03473 331271016010 3-alpha domain; Region: 3-alpha; pfam03475 331271016011 short chain dehydrogenase; Provisional; Region: PRK07023 331271016012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271016013 NAD(P) binding site [chemical binding]; other site 331271016014 active site 331271016015 Protein of unknown function, DUF480; Region: DUF480; pfam04337 331271016016 Secretory lipase; Region: LIP; pfam03583 331271016017 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 331271016018 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331271016019 PRC-barrel domain; Region: PRC; pfam05239 331271016020 OsmC-like protein; Region: OsmC; cl00767 331271016021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271016022 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331271016023 NAD(P) binding site [chemical binding]; other site 331271016024 active site 331271016025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016027 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271016028 putative effector binding pocket; other site 331271016029 dimerization interface [polypeptide binding]; other site 331271016030 Cupin domain; Region: Cupin_2; pfam07883 331271016031 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 331271016032 Uncharacterized conserved protein [Function unknown]; Region: COG2128 331271016033 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 331271016034 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271016035 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271016036 DNA binding residues [nucleotide binding] 331271016037 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 331271016038 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331271016039 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331271016040 AAA domain; Region: AAA_22; pfam13401 331271016041 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271016042 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331271016043 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 331271016044 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 331271016045 Putative glucoamylase; Region: Glycoamylase; pfam10091 331271016046 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 331271016047 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 331271016048 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 331271016049 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 331271016050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271016051 sequence-specific DNA binding site [nucleotide binding]; other site 331271016052 salt bridge; other site 331271016053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271016054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271016055 ligand binding site [chemical binding]; other site 331271016056 flexible hinge region; other site 331271016057 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 331271016058 non-specific DNA interactions [nucleotide binding]; other site 331271016059 DNA binding site [nucleotide binding] 331271016060 sequence specific DNA binding site [nucleotide binding]; other site 331271016061 putative cAMP binding site [chemical binding]; other site 331271016062 Transposase; Region: DDE_Tnp_ISL3; pfam01610 331271016063 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271016064 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271016065 ligand binding site [chemical binding]; other site 331271016066 flexible hinge region; other site 331271016067 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 331271016068 Fatty acid desaturase; Region: FA_desaturase; pfam00487 331271016069 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 331271016070 Di-iron ligands [ion binding]; other site 331271016071 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 331271016072 CsbD-like; Region: CsbD; pfam05532 331271016073 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 331271016074 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 331271016075 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 331271016076 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331271016077 TPP-binding site [chemical binding]; other site 331271016078 dimer interface [polypeptide binding]; other site 331271016079 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331271016080 PYR/PP interface [polypeptide binding]; other site 331271016081 dimer interface [polypeptide binding]; other site 331271016082 TPP binding site [chemical binding]; other site 331271016083 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331271016084 PRC-barrel domain; Region: PRC; pfam05239 331271016085 PRC-barrel domain; Region: PRC; pfam05239 331271016086 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331271016087 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331271016088 ligand binding site [chemical binding]; other site 331271016089 flexible hinge region; other site 331271016090 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 331271016091 Phage integrase protein; Region: DUF3701; pfam12482 331271016092 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 331271016093 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 331271016094 Int/Topo IB signature motif; other site 331271016095 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 331271016096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271016097 non-specific DNA binding site [nucleotide binding]; other site 331271016098 salt bridge; other site 331271016099 sequence-specific DNA binding site [nucleotide binding]; other site 331271016100 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 331271016101 Transposase, Mutator family; Region: Transposase_mut; pfam00872 331271016102 MULE transposase domain; Region: MULE; pfam10551 331271016103 carbon starvation protein A; Provisional; Region: PRK15015 331271016104 Carbon starvation protein CstA; Region: CstA; pfam02554 331271016105 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 331271016106 Protein of unknown function (DUF466); Region: DUF466; pfam04328 331271016107 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 331271016108 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 331271016109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016110 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271016111 putative substrate translocation pore; other site 331271016112 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 331271016113 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 331271016114 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271016115 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 331271016116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271016117 FeS/SAM binding site; other site 331271016118 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 331271016119 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 331271016120 LytB protein; Region: LYTB; pfam02401 331271016121 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 331271016122 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 331271016123 active site 331271016124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331271016125 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 331271016126 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 331271016127 putative NADP binding site [chemical binding]; other site 331271016128 putative substrate binding site [chemical binding]; other site 331271016129 active site 331271016130 acylphosphatase; Provisional; Region: PRK14424 331271016131 Predicted permeases [General function prediction only]; Region: RarD; COG2962 331271016132 OpgC protein; Region: OpgC_C; pfam10129 331271016133 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 331271016134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016135 putative substrate translocation pore; other site 331271016136 POT family; Region: PTR2; cl17359 331271016137 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 331271016138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271016139 non-specific DNA binding site [nucleotide binding]; other site 331271016140 salt bridge; other site 331271016141 sequence-specific DNA binding site [nucleotide binding]; other site 331271016142 Cupin domain; Region: Cupin_2; pfam07883 331271016143 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 331271016144 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 331271016145 peptide binding site [polypeptide binding]; other site 331271016146 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 331271016147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 331271016148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271016149 ABC-ATPase subunit interface; other site 331271016150 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 331271016151 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 331271016152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271016153 dimer interface [polypeptide binding]; other site 331271016154 conserved gate region; other site 331271016155 putative PBP binding loops; other site 331271016156 ABC-ATPase subunit interface; other site 331271016157 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 331271016158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271016159 Walker A/P-loop; other site 331271016160 ATP binding site [chemical binding]; other site 331271016161 Q-loop/lid; other site 331271016162 ABC transporter signature motif; other site 331271016163 Walker B; other site 331271016164 D-loop; other site 331271016165 H-loop/switch region; other site 331271016166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271016167 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 331271016168 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271016169 Walker A/P-loop; other site 331271016170 ATP binding site [chemical binding]; other site 331271016171 Q-loop/lid; other site 331271016172 ABC transporter signature motif; other site 331271016173 Walker B; other site 331271016174 D-loop; other site 331271016175 H-loop/switch region; other site 331271016176 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271016177 outer membrane porin, OprD family; Region: OprD; pfam03573 331271016178 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 331271016179 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 331271016180 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 331271016181 active site residue [active] 331271016182 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 331271016183 Phosphoesterase family; Region: Phosphoesterase; pfam04185 331271016184 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271016185 Domain of unknown function (DUF756); Region: DUF756; pfam05506 331271016186 putative acetyltransferase YhhY; Provisional; Region: PRK10140 331271016187 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271016188 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 331271016189 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271016190 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 331271016191 PAS fold; Region: PAS_4; pfam08448 331271016192 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 331271016193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271016194 Walker B motif; other site 331271016195 arginine finger; other site 331271016196 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271016197 H-NS histone family; Region: Histone_HNS; pfam00816 331271016198 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 331271016199 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 331271016200 CoA binding domain; Region: CoA_binding_2; pfam13380 331271016201 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 331271016202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271016203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271016204 Coenzyme A binding pocket [chemical binding]; other site 331271016205 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271016206 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 331271016207 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271016208 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331271016209 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271016210 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 331271016211 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271016212 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 331271016213 CGNR zinc finger; Region: zf-CGNR; pfam11706 331271016214 Propionate catabolism activator; Region: PrpR_N; pfam06506 331271016215 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 331271016216 PAS domain; Region: PAS; smart00091 331271016217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271016218 Walker A motif; other site 331271016219 ATP binding site [chemical binding]; other site 331271016220 Walker B motif; other site 331271016221 arginine finger; other site 331271016222 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 331271016223 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 331271016224 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 331271016225 tetramer interface [polypeptide binding]; other site 331271016226 active site 331271016227 Mg2+/Mn2+ binding site [ion binding]; other site 331271016228 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 331271016229 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 331271016230 dimer interface [polypeptide binding]; other site 331271016231 active site 331271016232 citrylCoA binding site [chemical binding]; other site 331271016233 oxalacetate/citrate binding site [chemical binding]; other site 331271016234 coenzyme A binding site [chemical binding]; other site 331271016235 catalytic triad [active] 331271016236 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 331271016237 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 331271016238 substrate binding site [chemical binding]; other site 331271016239 ligand binding site [chemical binding]; other site 331271016240 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 331271016241 substrate binding site [chemical binding]; other site 331271016242 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 331271016243 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 331271016244 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271016245 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271016246 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271016247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016248 putative substrate translocation pore; other site 331271016249 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271016250 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271016251 trimer interface [polypeptide binding]; other site 331271016252 eyelet of channel; other site 331271016253 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271016254 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 331271016255 substrate binding site [chemical binding]; other site 331271016256 oxyanion hole (OAH) forming residues; other site 331271016257 trimer interface [polypeptide binding]; other site 331271016258 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271016259 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271016260 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 331271016261 enoyl-CoA hydratase; Provisional; Region: PRK09245 331271016262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271016263 substrate binding site [chemical binding]; other site 331271016264 oxyanion hole (OAH) forming residues; other site 331271016265 trimer interface [polypeptide binding]; other site 331271016266 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 331271016267 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271016268 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271016269 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271016270 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 331271016271 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 331271016272 CoenzymeA binding site [chemical binding]; other site 331271016273 subunit interaction site [polypeptide binding]; other site 331271016274 PHB binding site; other site 331271016275 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 331271016276 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 331271016277 dimer interface [polypeptide binding]; other site 331271016278 ligand binding site [chemical binding]; other site 331271016279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271016280 dimer interface [polypeptide binding]; other site 331271016281 putative CheW interface [polypeptide binding]; other site 331271016282 dimerization interface [polypeptide binding]; other site 331271016283 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 331271016284 putative active cleft [active] 331271016285 MgtC family; Region: MgtC; pfam02308 331271016286 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271016287 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 331271016288 metal-binding site [ion binding] 331271016289 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 331271016290 metal-binding site [ion binding] 331271016291 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 331271016292 metal-binding site [ion binding] 331271016293 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 331271016294 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 331271016295 metal-binding site [ion binding] 331271016296 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331271016297 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271016298 motif II; other site 331271016299 Uncharacterized conserved protein [Function unknown]; Region: COG5361 331271016300 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 331271016301 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 331271016302 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 331271016303 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 331271016304 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 331271016305 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 331271016306 Sulfatase; Region: Sulfatase; cl17466 331271016307 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 331271016308 Sulfatase; Region: Sulfatase; cl17466 331271016309 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271016310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016311 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271016312 dimerization interface [polypeptide binding]; other site 331271016313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271016314 dimer interface [polypeptide binding]; other site 331271016315 conserved gate region; other site 331271016316 putative PBP binding loops; other site 331271016317 ABC-ATPase subunit interface; other site 331271016318 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 331271016319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271016320 Walker A/P-loop; other site 331271016321 ATP binding site [chemical binding]; other site 331271016322 Q-loop/lid; other site 331271016323 ABC transporter signature motif; other site 331271016324 Walker B; other site 331271016325 D-loop; other site 331271016326 H-loop/switch region; other site 331271016327 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 331271016328 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 331271016329 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271016330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271016331 dimer interface [polypeptide binding]; other site 331271016332 conserved gate region; other site 331271016333 putative PBP binding loops; other site 331271016334 ABC-ATPase subunit interface; other site 331271016335 Transposase domain (DUF772); Region: DUF772; pfam05598 331271016336 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331271016337 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331271016338 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 331271016339 HipA-like N-terminal domain; Region: HipA_N; pfam07805 331271016340 HipA-like C-terminal domain; Region: HipA_C; pfam07804 331271016341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271016342 non-specific DNA binding site [nucleotide binding]; other site 331271016343 salt bridge; other site 331271016344 sequence-specific DNA binding site [nucleotide binding]; other site 331271016345 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 331271016346 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 331271016347 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 331271016348 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 331271016349 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 331271016350 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 331271016351 tetramer interface [polypeptide binding]; other site 331271016352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271016353 catalytic residue [active] 331271016354 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 331271016355 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 331271016356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016357 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 331271016358 putative dimerization interface [polypeptide binding]; other site 331271016359 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 331271016360 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331271016361 active site residue [active] 331271016362 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271016363 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 331271016364 C-terminal domain interface [polypeptide binding]; other site 331271016365 GSH binding site (G-site) [chemical binding]; other site 331271016366 dimer interface [polypeptide binding]; other site 331271016367 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 331271016368 N-terminal domain interface [polypeptide binding]; other site 331271016369 dimer interface [polypeptide binding]; other site 331271016370 substrate binding pocket (H-site) [chemical binding]; other site 331271016371 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 331271016372 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 331271016373 active site 331271016374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016375 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271016376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016378 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271016379 putative effector binding pocket; other site 331271016380 dimerization interface [polypeptide binding]; other site 331271016381 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 331271016382 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 331271016383 putative catalytic residue [active] 331271016384 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271016385 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271016386 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271016387 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 331271016388 active site 331271016389 catalytic residues [active] 331271016390 metal binding site [ion binding]; metal-binding site 331271016391 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271016392 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271016393 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271016394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016395 putative substrate translocation pore; other site 331271016396 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271016397 Amidohydrolase; Region: Amidohydro_2; pfam04909 331271016398 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 331271016399 putative hydrophobic ligand binding site [chemical binding]; other site 331271016400 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 331271016401 putative hydrophobic ligand binding site [chemical binding]; other site 331271016402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271016403 dimerization interface [polypeptide binding]; other site 331271016404 putative DNA binding site [nucleotide binding]; other site 331271016405 putative Zn2+ binding site [ion binding]; other site 331271016406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271016407 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 331271016408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271016409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271016410 short chain dehydrogenase; Validated; Region: PRK08264 331271016411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271016412 NAD(P) binding site [chemical binding]; other site 331271016413 active site 331271016414 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 331271016415 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 331271016416 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 331271016417 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 331271016418 Predicted transcriptional regulators [Transcription]; Region: COG1510 331271016419 MarR family; Region: MarR_2; pfam12802 331271016420 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 331271016421 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331271016422 putative NAD(P) binding site [chemical binding]; other site 331271016423 active site 331271016424 DoxX-like family; Region: DoxX_3; pfam13781 331271016425 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 331271016426 Protein of unknown function, DUF393; Region: DUF393; pfam04134 331271016427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271016428 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 331271016429 NAD(P) binding site [chemical binding]; other site 331271016430 active site 331271016431 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271016432 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 331271016433 putative C-terminal domain interface [polypeptide binding]; other site 331271016434 putative GSH binding site (G-site) [chemical binding]; other site 331271016435 putative dimer interface [polypeptide binding]; other site 331271016436 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 331271016437 putative N-terminal domain interface [polypeptide binding]; other site 331271016438 putative dimer interface [polypeptide binding]; other site 331271016439 putative substrate binding pocket (H-site) [chemical binding]; other site 331271016440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 331271016441 Beta-lactamase; Region: Beta-lactamase; pfam00144 331271016442 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 331271016443 HIT family signature motif; other site 331271016444 catalytic residue [active] 331271016445 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 331271016446 hypothetical protein; Provisional; Region: PRK11171 331271016447 Cupin domain; Region: Cupin_2; pfam07883 331271016448 Cupin domain; Region: Cupin_2; pfam07883 331271016449 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016451 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 331271016452 putative substrate binding pocket [chemical binding]; other site 331271016453 putative dimerization interface [polypeptide binding]; other site 331271016454 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 331271016455 Transglycosylase; Region: Transgly; pfam00912 331271016456 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 331271016457 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331271016458 Predicted membrane protein [Function unknown]; Region: COG2860 331271016459 UPF0126 domain; Region: UPF0126; pfam03458 331271016460 UPF0126 domain; Region: UPF0126; pfam03458 331271016461 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 331271016462 active site 331271016463 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 331271016464 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 331271016465 Walker A/P-loop; other site 331271016466 ATP binding site [chemical binding]; other site 331271016467 Q-loop/lid; other site 331271016468 ABC transporter signature motif; other site 331271016469 Walker B; other site 331271016470 D-loop; other site 331271016471 H-loop/switch region; other site 331271016472 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 331271016473 putative PBP binding regions; other site 331271016474 ABC-ATPase subunit interface; other site 331271016475 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 331271016476 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 331271016477 intersubunit interface [polypeptide binding]; other site 331271016478 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 331271016479 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 331271016480 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 331271016481 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 331271016482 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271016483 N-terminal plug; other site 331271016484 ligand-binding site [chemical binding]; other site 331271016485 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 331271016486 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271016487 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271016488 trimer interface [polypeptide binding]; other site 331271016489 eyelet of channel; other site 331271016490 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 331271016491 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 331271016492 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 331271016493 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 331271016494 active site 331271016495 Zn binding site [ion binding]; other site 331271016496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271016497 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271016498 substrate binding pocket [chemical binding]; other site 331271016499 membrane-bound complex binding site; other site 331271016500 hinge residues; other site 331271016501 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 331271016502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271016504 dimerization interface [polypeptide binding]; other site 331271016505 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 331271016506 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271016507 conserved cys residue [active] 331271016508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271016509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271016510 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 331271016511 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 331271016512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271016513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271016514 Methyltransferase domain; Region: Methyltransf_24; pfam13578 331271016515 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 331271016516 Putative cyclase; Region: Cyclase; pfam04199 331271016517 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331271016518 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331271016519 FMN binding site [chemical binding]; other site 331271016520 active site 331271016521 substrate binding site [chemical binding]; other site 331271016522 catalytic residue [active] 331271016523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271016524 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271016525 active site 331271016526 catalytic tetrad [active] 331271016527 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 331271016528 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 331271016529 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 331271016530 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 331271016531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016532 putative substrate translocation pore; other site 331271016533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271016536 dimerization interface [polypeptide binding]; other site 331271016537 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 331271016538 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 331271016539 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 331271016540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271016541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271016542 short chain dehydrogenase; Provisional; Region: PRK06180 331271016543 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271016544 NADP binding site [chemical binding]; other site 331271016545 active site 331271016546 steroid binding site; other site 331271016547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271016550 dimerization interface [polypeptide binding]; other site 331271016551 Beta-lactamase; Region: Beta-lactamase; pfam00144 331271016552 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 331271016553 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 331271016554 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 331271016555 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 331271016556 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 331271016557 NADP binding site [chemical binding]; other site 331271016558 dimer interface [polypeptide binding]; other site 331271016559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271016560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271016561 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271016562 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271016563 hypothetical protein; Validated; Region: PRK06201 331271016564 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 331271016565 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 331271016566 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 331271016567 ligand binding site [chemical binding]; other site 331271016568 NAD binding site [chemical binding]; other site 331271016569 dimerization interface [polypeptide binding]; other site 331271016570 catalytic site [active] 331271016571 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 331271016572 Strictosidine synthase; Region: Str_synth; pfam03088 331271016573 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271016574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016575 putative substrate translocation pore; other site 331271016576 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271016577 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271016578 trimer interface [polypeptide binding]; other site 331271016579 eyelet of channel; other site 331271016580 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271016581 Amidohydrolase; Region: Amidohydro_2; pfam04909 331271016582 benzoate transport; Region: 2A0115; TIGR00895 331271016583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016584 putative substrate translocation pore; other site 331271016585 H+ Antiporter protein; Region: 2A0121; TIGR00900 331271016586 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271016587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016588 putative substrate translocation pore; other site 331271016589 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271016590 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331271016591 active site 331271016592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016594 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 331271016595 putative effector binding pocket; other site 331271016596 putative dimerization interface [polypeptide binding]; other site 331271016597 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 331271016598 putative NAD(P) binding site [chemical binding]; other site 331271016599 homodimer interface [polypeptide binding]; other site 331271016600 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271016601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016603 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 331271016604 putative effector binding pocket; other site 331271016605 putative dimerization interface [polypeptide binding]; other site 331271016606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016608 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 331271016609 putative effector binding pocket; other site 331271016610 putative dimerization interface [polypeptide binding]; other site 331271016611 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271016612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271016613 catalytic loop [active] 331271016614 iron binding site [ion binding]; other site 331271016615 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271016616 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271016617 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271016618 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271016619 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271016620 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 331271016621 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271016622 catalytic loop [active] 331271016623 iron binding site [ion binding]; other site 331271016624 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 331271016625 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 331271016626 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 331271016627 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271016628 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 331271016629 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271016630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271016631 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 331271016632 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 331271016633 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 331271016634 short chain dehydrogenase; Provisional; Region: PRK08265 331271016635 classical (c) SDRs; Region: SDR_c; cd05233 331271016636 NAD(P) binding site [chemical binding]; other site 331271016637 active site 331271016638 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 331271016639 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 331271016640 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 331271016641 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 331271016642 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271016643 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 331271016644 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331271016645 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 331271016646 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 331271016647 ATP binding site [chemical binding]; other site 331271016648 Walker A motif; other site 331271016649 hexamer interface [polypeptide binding]; other site 331271016650 Walker B motif; other site 331271016651 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 331271016652 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 331271016653 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 331271016654 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 331271016655 TadE-like protein; Region: TadE; pfam07811 331271016656 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 331271016657 TadE-like protein; Region: TadE; pfam07811 331271016658 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 331271016659 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 331271016660 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 331271016661 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 331271016662 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 331271016663 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 331271016664 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 331271016665 active site 331271016666 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 331271016667 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 331271016668 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 331271016669 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 331271016670 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 331271016671 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 331271016672 Ligand binding site; other site 331271016673 Putative Catalytic site; other site 331271016674 DXD motif; other site 331271016675 Predicted membrane protein [Function unknown]; Region: COG2246 331271016676 GtrA-like protein; Region: GtrA; pfam04138 331271016677 Inclusion body protein; Region: PixA; pfam12306 331271016678 Inclusion body protein; Region: PixA; pfam12306 331271016679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271016680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271016681 substrate binding pocket [chemical binding]; other site 331271016682 membrane-bound complex binding site; other site 331271016683 hinge residues; other site 331271016684 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 331271016685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016686 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271016687 putative substrate translocation pore; other site 331271016688 hypothetical protein; Provisional; Region: PRK07206 331271016689 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 331271016690 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016691 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016692 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271016693 dimerization interface [polypeptide binding]; other site 331271016694 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 331271016695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016696 putative substrate translocation pore; other site 331271016697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271016698 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 331271016699 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016700 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 331271016701 dimerization interface [polypeptide binding]; other site 331271016702 substrate binding pocket [chemical binding]; other site 331271016703 NIPSNAP; Region: NIPSNAP; pfam07978 331271016704 NIPSNAP; Region: NIPSNAP; pfam07978 331271016705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271016708 dimerization interface [polypeptide binding]; other site 331271016709 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 331271016710 DNA-binding site [nucleotide binding]; DNA binding site 331271016711 RNA-binding motif; other site 331271016712 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271016713 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271016714 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271016715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271016716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271016717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016719 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 331271016720 substrate binding pocket [chemical binding]; other site 331271016721 dimerization interface [polypeptide binding]; other site 331271016722 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 331271016723 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 331271016724 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 331271016725 active site 331271016726 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 331271016727 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 331271016728 active site 331271016729 catalytic site [active] 331271016730 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271016731 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271016732 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 331271016733 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 331271016734 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 331271016735 shikimate binding site; other site 331271016736 NAD(P) binding site [chemical binding]; other site 331271016737 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 331271016738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016739 putative substrate translocation pore; other site 331271016740 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 331271016741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271016742 S-adenosylmethionine binding site [chemical binding]; other site 331271016743 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271016744 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 331271016745 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271016746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016747 putative substrate translocation pore; other site 331271016748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016750 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271016751 dimerization interface [polypeptide binding]; other site 331271016752 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 331271016753 tartrate dehydrogenase; Region: TTC; TIGR02089 331271016754 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271016755 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 331271016756 NAD(P) binding site [chemical binding]; other site 331271016757 catalytic residues [active] 331271016758 catalytic residues [active] 331271016759 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 331271016760 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331271016761 dimer interface [polypeptide binding]; other site 331271016762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271016763 catalytic residue [active] 331271016764 MAPEG family; Region: MAPEG; pfam01124 331271016765 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 331271016766 NmrA (a transcriptional regulator), HSCARG (an NADPH sensor), and triphenylmethane reductase (TMR) like proteins, atypical (a) SDRs; Region: NmrA_TMR_like_SDR_a; cd08947 331271016767 NADP binding site [chemical binding]; other site 331271016768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016770 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271016771 putative effector binding pocket; other site 331271016772 dimerization interface [polypeptide binding]; other site 331271016773 Probable transposase; Region: OrfB_IS605; pfam01385 331271016774 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271016775 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271016776 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 331271016777 conserved cys residue [active] 331271016778 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 331271016779 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 331271016780 NADP binding site [chemical binding]; other site 331271016781 active site 331271016782 steroid binding site; other site 331271016783 Transcriptional regulators [Transcription]; Region: GntR; COG1802 331271016784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271016785 DNA-binding site [nucleotide binding]; DNA binding site 331271016786 FCD domain; Region: FCD; pfam07729 331271016787 aminotransferase; Validated; Region: PRK07046 331271016788 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271016789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271016790 catalytic residue [active] 331271016791 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 331271016792 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 331271016793 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 331271016794 short chain dehydrogenase; Provisional; Region: PRK06500 331271016795 classical (c) SDRs; Region: SDR_c; cd05233 331271016796 NAD(P) binding site [chemical binding]; other site 331271016797 active site 331271016798 LysR family transcriptional regulator; Provisional; Region: PRK14997 331271016799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016800 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271016801 putative effector binding pocket; other site 331271016802 dimerization interface [polypeptide binding]; other site 331271016803 transcriptional regulator, ArgP family; Region: argP; TIGR03298 331271016804 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 331271016805 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271016806 substrate binding pocket [chemical binding]; other site 331271016807 membrane-bound complex binding site; other site 331271016808 hinge residues; other site 331271016809 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271016810 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271016811 Walker A/P-loop; other site 331271016812 ATP binding site [chemical binding]; other site 331271016813 Q-loop/lid; other site 331271016814 ABC transporter signature motif; other site 331271016815 Walker B; other site 331271016816 D-loop; other site 331271016817 H-loop/switch region; other site 331271016818 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271016819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271016820 dimer interface [polypeptide binding]; other site 331271016821 conserved gate region; other site 331271016822 putative PBP binding loops; other site 331271016823 ABC-ATPase subunit interface; other site 331271016824 urea carboxylase; Region: urea_carbox; TIGR02712 331271016825 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331271016826 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331271016827 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 331271016828 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 331271016829 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 331271016830 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331271016831 carboxyltransferase (CT) interaction site; other site 331271016832 biotinylation site [posttranslational modification]; other site 331271016833 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 331271016834 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 331271016835 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 331271016836 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 331271016837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271016838 substrate binding pocket [chemical binding]; other site 331271016839 membrane-bound complex binding site; other site 331271016840 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 331271016841 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 331271016842 hexamer interface [polypeptide binding]; other site 331271016843 active site 331271016844 metal binding site [ion binding]; metal-binding site 331271016845 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271016846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271016847 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271016848 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 331271016849 nudix motif; other site 331271016850 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 331271016851 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 331271016852 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 331271016853 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016854 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271016855 dimerization interface [polypeptide binding]; other site 331271016856 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 331271016857 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 331271016858 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 331271016859 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 331271016860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271016861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271016862 dimer interface [polypeptide binding]; other site 331271016863 phosphorylation site [posttranslational modification] 331271016864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271016865 ATP binding site [chemical binding]; other site 331271016866 Mg2+ binding site [ion binding]; other site 331271016867 G-X-G motif; other site 331271016868 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 331271016869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271016870 active site 331271016871 phosphorylation site [posttranslational modification] 331271016872 intermolecular recognition site; other site 331271016873 dimerization interface [polypeptide binding]; other site 331271016874 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331271016875 Zn2+ binding site [ion binding]; other site 331271016876 Mg2+ binding site [ion binding]; other site 331271016877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331271016878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271016879 Coenzyme A binding pocket [chemical binding]; other site 331271016880 RNase II stability modulator; Provisional; Region: PRK10060 331271016881 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 331271016882 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271016883 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 331271016884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271016885 DNA-binding site [nucleotide binding]; DNA binding site 331271016886 FCD domain; Region: FCD; pfam07729 331271016887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271016888 Coenzyme A binding pocket [chemical binding]; other site 331271016889 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271016890 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271016891 eyelet of channel; other site 331271016892 trimer interface [polypeptide binding]; other site 331271016893 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271016894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016895 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271016896 dimerization interface [polypeptide binding]; other site 331271016897 substrate binding pocket [chemical binding]; other site 331271016898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271016899 putative substrate translocation pore; other site 331271016900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271016901 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 331271016902 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 331271016903 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 331271016904 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 331271016905 Putative amidotransferase; Region: DUF4066; pfam13278 331271016906 conserved cys residue [active] 331271016907 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 331271016908 Uncharacterized conserved protein [Function unknown]; Region: COG4275 331271016909 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 331271016910 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 331271016911 Chromate transporter; Region: Chromate_transp; pfam02417 331271016912 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 331271016913 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 331271016914 Transposase domain (DUF772); Region: DUF772; pfam05598 331271016915 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331271016916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271016917 HAMP domain; Region: HAMP; pfam00672 331271016918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271016919 dimer interface [polypeptide binding]; other site 331271016920 phosphorylation site [posttranslational modification] 331271016921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271016922 ATP binding site [chemical binding]; other site 331271016923 Mg2+ binding site [ion binding]; other site 331271016924 G-X-G motif; other site 331271016925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271016926 active site 331271016927 phosphorylation site [posttranslational modification] 331271016928 intermolecular recognition site; other site 331271016929 dimerization interface [polypeptide binding]; other site 331271016930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271016931 DNA binding site [nucleotide binding] 331271016932 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 331271016933 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271016934 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271016935 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 331271016936 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271016937 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 331271016938 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271016939 substrate binding pocket [chemical binding]; other site 331271016940 membrane-bound complex binding site; other site 331271016941 hinge residues; other site 331271016942 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 331271016943 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271016944 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271016945 catalytic residue [active] 331271016946 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 331271016947 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271016948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271016949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271016950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 331271016951 dimerization interface [polypeptide binding]; other site 331271016952 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 331271016953 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271016954 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271016955 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271016956 substrate binding pocket [chemical binding]; other site 331271016957 membrane-bound complex binding site; other site 331271016958 hinge residues; other site 331271016959 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 331271016960 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331271016961 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331271016962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271016963 Walker A/P-loop; other site 331271016964 ATP binding site [chemical binding]; other site 331271016965 Q-loop/lid; other site 331271016966 ABC transporter signature motif; other site 331271016967 Walker B; other site 331271016968 D-loop; other site 331271016969 H-loop/switch region; other site 331271016970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271016971 Walker A/P-loop; other site 331271016972 ATP binding site [chemical binding]; other site 331271016973 Q-loop/lid; other site 331271016974 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 331271016975 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331271016976 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 331271016977 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 331271016978 Putative cyclase; Region: Cyclase; pfam04199 331271016979 fumarylacetoacetase; Region: PLN02856 331271016980 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 331271016981 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271016982 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271016983 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271016984 trimer interface [polypeptide binding]; other site 331271016985 eyelet of channel; other site 331271016986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271016987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271016988 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 331271016989 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331271016990 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331271016991 ligand binding site [chemical binding]; other site 331271016992 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 331271016993 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 331271016994 trimer interface [polypeptide binding]; other site 331271016995 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 331271016996 trimer interface [polypeptide binding]; other site 331271016997 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 331271016998 trimer interface [polypeptide binding]; other site 331271016999 YadA-like C-terminal region; Region: YadA; pfam03895 331271017000 Response regulator receiver domain; Region: Response_reg; pfam00072 331271017001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271017002 active site 331271017003 phosphorylation site [posttranslational modification] 331271017004 intermolecular recognition site; other site 331271017005 dimerization interface [polypeptide binding]; other site 331271017006 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271017007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017008 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 331271017009 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 331271017010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271017011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271017012 dimer interface [polypeptide binding]; other site 331271017013 phosphorylation site [posttranslational modification] 331271017014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271017015 ATP binding site [chemical binding]; other site 331271017016 Mg2+ binding site [ion binding]; other site 331271017017 G-X-G motif; other site 331271017018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271017019 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271017020 TM-ABC transporter signature motif; other site 331271017021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271017022 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271017023 TM-ABC transporter signature motif; other site 331271017024 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271017025 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271017026 Walker A/P-loop; other site 331271017027 ATP binding site [chemical binding]; other site 331271017028 Q-loop/lid; other site 331271017029 ABC transporter signature motif; other site 331271017030 Walker B; other site 331271017031 D-loop; other site 331271017032 H-loop/switch region; other site 331271017033 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271017034 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 331271017035 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271017036 putative ligand binding site [chemical binding]; other site 331271017037 Pirin-related protein [General function prediction only]; Region: COG1741 331271017038 Pirin; Region: Pirin; pfam02678 331271017039 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 331271017040 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271017041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271017042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017043 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271017044 putative effector binding pocket; other site 331271017045 dimerization interface [polypeptide binding]; other site 331271017046 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 331271017047 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 331271017048 active site 331271017049 DNA binding site [nucleotide binding] 331271017050 Int/Topo IB signature motif; other site 331271017051 catalytic residues [active] 331271017052 proline/glycine betaine transporter; Provisional; Region: PRK10642 331271017053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271017054 putative substrate translocation pore; other site 331271017055 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 331271017056 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 331271017057 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271017058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017059 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271017060 dimerization interface [polypeptide binding]; other site 331271017061 substrate binding pocket [chemical binding]; other site 331271017062 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 331271017063 dinuclear metal binding motif [ion binding]; other site 331271017064 Fatty acid desaturase; Region: FA_desaturase; pfam00487 331271017065 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 331271017066 putative di-iron ligands [ion binding]; other site 331271017067 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 331271017068 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 331271017069 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 331271017070 acyl-activating enzyme (AAE) consensus motif; other site 331271017071 active site 331271017072 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331271017073 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331271017074 Walker A/P-loop; other site 331271017075 ATP binding site [chemical binding]; other site 331271017076 Q-loop/lid; other site 331271017077 ABC transporter signature motif; other site 331271017078 Walker B; other site 331271017079 D-loop; other site 331271017080 H-loop/switch region; other site 331271017081 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331271017082 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331271017083 FtsX-like permease family; Region: FtsX; pfam02687 331271017084 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 331271017085 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 331271017086 dinuclear metal binding motif [ion binding]; other site 331271017087 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 331271017088 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 331271017089 dimer interface [polypeptide binding]; other site 331271017090 active site 331271017091 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 331271017092 dimer interface [polypeptide binding]; other site 331271017093 active site 331271017094 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331271017095 catalytic residues [active] 331271017096 substrate binding site [chemical binding]; other site 331271017097 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 331271017098 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271017099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331271017100 acyl-activating enzyme (AAE) consensus motif; other site 331271017101 acyl-activating enzyme (AAE) consensus motif; other site 331271017102 AMP binding site [chemical binding]; other site 331271017103 active site 331271017104 CoA binding site [chemical binding]; other site 331271017105 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271017106 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271017107 active site 331271017108 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 331271017109 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 331271017110 citrylCoA binding site [chemical binding]; other site 331271017111 oxalacetate binding site [chemical binding]; other site 331271017112 coenzyme A binding site [chemical binding]; other site 331271017113 catalytic triad [active] 331271017114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271017115 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 331271017116 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 331271017117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271017118 Walker A/P-loop; other site 331271017119 ATP binding site [chemical binding]; other site 331271017120 Q-loop/lid; other site 331271017121 ABC transporter signature motif; other site 331271017122 Walker B; other site 331271017123 D-loop; other site 331271017124 H-loop/switch region; other site 331271017125 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 331271017126 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331271017127 FAD binding domain; Region: FAD_binding_4; pfam01565 331271017128 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 331271017129 DctM-like transporters; Region: DctM; pfam06808 331271017130 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 331271017131 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 331271017132 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 331271017133 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 331271017134 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 331271017135 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 331271017136 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 331271017137 dimerization interface [polypeptide binding]; other site 331271017138 DNA binding residues [nucleotide binding] 331271017139 cinnamoyl-CoA reductase; Region: PLN02214 331271017140 flavonoid reductase (FR), extended (e) SDRs; Region: FR_SDR_e; cd08958 331271017141 NADP binding site [chemical binding]; other site 331271017142 substrate binding site [chemical binding]; other site 331271017143 active site 331271017144 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271017145 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271017146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017147 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 331271017148 homotrimer interaction site [polypeptide binding]; other site 331271017149 putative active site [active] 331271017150 H-NS histone family; Region: Histone_HNS; pfam00816 331271017151 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 331271017152 Cupin domain; Region: Cupin_2; pfam07883 331271017153 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271017154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017156 dimerization interface [polypeptide binding]; other site 331271017157 LysE type translocator; Region: LysE; cl00565 331271017158 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 331271017159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017161 dimerization interface [polypeptide binding]; other site 331271017162 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 331271017163 NAD(P) binding site [chemical binding]; other site 331271017164 catalytic residues [active] 331271017165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271017166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271017167 WHG domain; Region: WHG; pfam13305 331271017168 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 331271017169 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 331271017170 potential catalytic triad [active] 331271017171 conserved cys residue [active] 331271017172 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331271017173 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 331271017174 DNA binding residues [nucleotide binding] 331271017175 Uncharacterized conserved protein [Function unknown]; Region: COG3268 331271017176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271017177 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 331271017178 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786 331271017179 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 331271017180 DNA binding residues [nucleotide binding] 331271017181 putative dimer interface [polypeptide binding]; other site 331271017182 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271017183 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271017184 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 331271017185 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 331271017186 HAMP domain; Region: HAMP; pfam00672 331271017187 dimerization interface [polypeptide binding]; other site 331271017188 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271017189 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271017190 dimer interface [polypeptide binding]; other site 331271017191 putative CheW interface [polypeptide binding]; other site 331271017192 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331271017193 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 331271017194 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271017195 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017196 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017197 dimerization interface [polypeptide binding]; other site 331271017198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271017199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017200 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 331271017201 putative effector binding pocket; other site 331271017202 putative dimerization interface [polypeptide binding]; other site 331271017203 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 331271017204 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271017205 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271017206 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271017207 active site 331271017208 catalytic tetrad [active] 331271017209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271017210 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 331271017211 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 331271017212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271017213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271017214 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 331271017215 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 331271017216 Active site cavity [active] 331271017217 catalytic acid [active] 331271017218 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 331271017219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017220 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 331271017221 putative dimerization interface [polypeptide binding]; other site 331271017222 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271017223 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271017224 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 331271017225 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 331271017226 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271017227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271017228 substrate binding pocket [chemical binding]; other site 331271017229 membrane-bound complex binding site; other site 331271017230 hinge residues; other site 331271017231 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 331271017232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017233 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 331271017234 dimerization interface [polypeptide binding]; other site 331271017235 substrate binding pocket [chemical binding]; other site 331271017236 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 331271017237 putative hydrophobic ligand binding site [chemical binding]; other site 331271017238 protein interface [polypeptide binding]; other site 331271017239 gate; other site 331271017240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271017241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271017242 active site 331271017243 catalytic tetrad [active] 331271017244 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271017245 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271017246 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271017247 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271017248 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331271017249 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331271017250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271017251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017253 dimerization interface [polypeptide binding]; other site 331271017254 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331271017255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271017256 NAD(P) binding site [chemical binding]; other site 331271017257 active site 331271017258 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 331271017259 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 331271017260 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 331271017261 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 331271017262 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331271017263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271017264 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 331271017265 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 331271017266 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 331271017267 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 331271017268 Uncharacterized conserved protein [Function unknown]; Region: COG5476 331271017269 MlrC C-terminus; Region: MlrC_C; pfam07171 331271017270 allantoate amidohydrolase; Reviewed; Region: PRK12893 331271017271 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 331271017272 active site 331271017273 metal binding site [ion binding]; metal-binding site 331271017274 dimer interface [polypeptide binding]; other site 331271017275 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331271017276 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271017277 Walker A/P-loop; other site 331271017278 ATP binding site [chemical binding]; other site 331271017279 Q-loop/lid; other site 331271017280 ABC transporter signature motif; other site 331271017281 Walker B; other site 331271017282 D-loop; other site 331271017283 H-loop/switch region; other site 331271017284 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331271017285 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271017286 Walker A/P-loop; other site 331271017287 ATP binding site [chemical binding]; other site 331271017288 Q-loop/lid; other site 331271017289 ABC transporter signature motif; other site 331271017290 Walker B; other site 331271017291 D-loop; other site 331271017292 H-loop/switch region; other site 331271017293 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331271017294 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271017295 TM-ABC transporter signature motif; other site 331271017296 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271017297 TM-ABC transporter signature motif; other site 331271017298 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 331271017299 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 331271017300 putative ligand binding site [chemical binding]; other site 331271017301 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271017302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271017303 DNA-binding site [nucleotide binding]; DNA binding site 331271017304 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 331271017305 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 331271017306 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271017307 NAD binding site [chemical binding]; other site 331271017308 catalytic residues [active] 331271017309 hypothetical protein; Provisional; Region: PRK06541 331271017310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271017311 inhibitor-cofactor binding pocket; inhibition site 331271017312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271017313 catalytic residue [active] 331271017314 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 331271017315 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271017316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271017317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017318 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271017319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271017320 dimer interface [polypeptide binding]; other site 331271017321 conserved gate region; other site 331271017322 putative PBP binding loops; other site 331271017323 ABC-ATPase subunit interface; other site 331271017324 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 331271017325 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 331271017326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271017327 dimer interface [polypeptide binding]; other site 331271017328 conserved gate region; other site 331271017329 putative PBP binding loops; other site 331271017330 ABC-ATPase subunit interface; other site 331271017331 Predicted transcriptional regulator [Transcription]; Region: COG3355 331271017332 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271017333 putative DNA binding site [nucleotide binding]; other site 331271017334 putative Zn2+ binding site [ion binding]; other site 331271017335 MarR family; Region: MarR_2; cl17246 331271017336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271017337 Coenzyme A binding pocket [chemical binding]; other site 331271017338 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331271017339 benzoate transport; Region: 2A0115; TIGR00895 331271017340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271017341 putative substrate translocation pore; other site 331271017342 H-NS histone family; Region: Histone_HNS; pfam00816 331271017343 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 331271017344 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 331271017345 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 331271017346 putative active site [active] 331271017347 putative NTP binding site [chemical binding]; other site 331271017348 putative nucleic acid binding site [nucleotide binding]; other site 331271017349 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 331271017350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271017351 DNA-binding site [nucleotide binding]; DNA binding site 331271017352 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 331271017353 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 331271017354 active sites [active] 331271017355 tetramer interface [polypeptide binding]; other site 331271017356 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 331271017357 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 331271017358 Walker A/P-loop; other site 331271017359 ATP binding site [chemical binding]; other site 331271017360 Q-loop/lid; other site 331271017361 ABC transporter signature motif; other site 331271017362 Walker B; other site 331271017363 D-loop; other site 331271017364 H-loop/switch region; other site 331271017365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271017366 dimer interface [polypeptide binding]; other site 331271017367 conserved gate region; other site 331271017368 putative PBP binding loops; other site 331271017369 ABC-ATPase subunit interface; other site 331271017370 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331271017371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271017372 dimer interface [polypeptide binding]; other site 331271017373 conserved gate region; other site 331271017374 putative PBP binding loops; other site 331271017375 ABC-ATPase subunit interface; other site 331271017376 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 331271017377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271017378 substrate binding pocket [chemical binding]; other site 331271017379 membrane-bound complex binding site; other site 331271017380 hinge residues; other site 331271017381 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 331271017382 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 331271017383 NADP binding site [chemical binding]; other site 331271017384 active site 331271017385 putative substrate binding site [chemical binding]; other site 331271017386 Predicted membrane protein [Function unknown]; Region: COG2259 331271017387 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 331271017388 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 331271017389 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 331271017390 Nitrate and nitrite sensing; Region: NIT; pfam08376 331271017391 ANTAR domain; Region: ANTAR; pfam03861 331271017392 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 331271017393 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271017394 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271017395 inhibitor site; inhibition site 331271017396 active site 331271017397 dimer interface [polypeptide binding]; other site 331271017398 catalytic residue [active] 331271017399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271017400 D-galactonate transporter; Region: 2A0114; TIGR00893 331271017401 putative substrate translocation pore; other site 331271017402 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271017403 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 331271017404 substrate binding site [chemical binding]; other site 331271017405 dimer interface [polypeptide binding]; other site 331271017406 ATP binding site [chemical binding]; other site 331271017407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271017408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271017409 DNA binding site [nucleotide binding] 331271017410 domain linker motif; other site 331271017411 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 331271017412 putative dimerization interface [polypeptide binding]; other site 331271017413 putative ligand binding site [chemical binding]; other site 331271017414 Fic family protein [Function unknown]; Region: COG3177 331271017415 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 331271017416 Fic/DOC family; Region: Fic; pfam02661 331271017417 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 331271017418 LysR family transcriptional regulator; Provisional; Region: PRK14997 331271017419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017420 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271017421 putative effector binding pocket; other site 331271017422 dimerization interface [polypeptide binding]; other site 331271017423 Pirin-related protein [General function prediction only]; Region: COG1741 331271017424 Pirin; Region: Pirin; pfam02678 331271017425 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 331271017426 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271017427 LrgA family; Region: LrgA; pfam03788 331271017428 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 331271017429 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271017430 substrate binding pocket [chemical binding]; other site 331271017431 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271017432 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 331271017433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271017434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271017435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271017436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271017437 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 331271017438 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 331271017439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331271017440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331271017441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271017442 Walker A/P-loop; other site 331271017443 ATP binding site [chemical binding]; other site 331271017444 Q-loop/lid; other site 331271017445 ABC transporter signature motif; other site 331271017446 Walker B; other site 331271017447 D-loop; other site 331271017448 H-loop/switch region; other site 331271017449 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271017450 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271017451 trimer interface [polypeptide binding]; other site 331271017452 eyelet of channel; other site 331271017453 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 331271017454 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 331271017455 putative C-terminal domain interface [polypeptide binding]; other site 331271017456 putative GSH binding site (G-site) [chemical binding]; other site 331271017457 putative dimer interface [polypeptide binding]; other site 331271017458 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 331271017459 putative N-terminal domain interface [polypeptide binding]; other site 331271017460 putative dimer interface [polypeptide binding]; other site 331271017461 putative substrate binding pocket (H-site) [chemical binding]; other site 331271017462 Acyltransferase family; Region: Acyl_transf_3; pfam01757 331271017463 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271017464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017466 dimerization interface [polypeptide binding]; other site 331271017467 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 331271017468 EamA-like transporter family; Region: EamA; pfam00892 331271017469 EamA-like transporter family; Region: EamA; pfam00892 331271017470 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271017471 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 331271017472 dimerization interface [polypeptide binding]; other site 331271017473 ligand binding site [chemical binding]; other site 331271017474 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331271017475 FAD binding domain; Region: FAD_binding_4; pfam01565 331271017476 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331271017477 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271017478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017479 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271017480 dimerization interface [polypeptide binding]; other site 331271017481 substrate binding pocket [chemical binding]; other site 331271017482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271017483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017485 dimerization interface [polypeptide binding]; other site 331271017486 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271017487 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 331271017488 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 331271017489 active site 331271017490 dimer interface [polypeptide binding]; other site 331271017491 non-prolyl cis peptide bond; other site 331271017492 insertion regions; other site 331271017493 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271017494 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 331271017495 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 331271017496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271017497 Walker A motif; other site 331271017498 ATP binding site [chemical binding]; other site 331271017499 Walker B motif; other site 331271017500 arginine finger; other site 331271017501 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 331271017502 dihydroxyacetone kinase; Provisional; Region: PRK14479 331271017503 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 331271017504 DAK2 domain; Region: Dak2; pfam02734 331271017505 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 331271017506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271017507 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271017508 putative substrate translocation pore; other site 331271017509 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271017510 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 331271017511 DNA-binding site [nucleotide binding]; DNA binding site 331271017512 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271017513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271017514 homodimer interface [polypeptide binding]; other site 331271017515 catalytic residue [active] 331271017516 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331271017517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 331271017518 hypothetical protein; Provisional; Region: PRK07482 331271017519 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271017520 inhibitor-cofactor binding pocket; inhibition site 331271017521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271017522 catalytic residue [active] 331271017523 succinic semialdehyde dehydrogenase; Region: PLN02278 331271017524 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 331271017525 tetramerization interface [polypeptide binding]; other site 331271017526 NAD(P) binding site [chemical binding]; other site 331271017527 catalytic residues [active] 331271017528 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271017529 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271017530 putative DNA binding site [nucleotide binding]; other site 331271017531 putative Zn2+ binding site [ion binding]; other site 331271017532 AsnC family; Region: AsnC_trans_reg; pfam01037 331271017533 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 331271017534 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 331271017535 putative active site [active] 331271017536 Zn binding site [ion binding]; other site 331271017537 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 331271017538 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 331271017539 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 331271017540 active site 331271017541 ectoine utilization protein EutC; Validated; Region: PRK08291 331271017542 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 331271017543 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 331271017544 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 331271017545 tetramer interface [polypeptide binding]; other site 331271017546 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271017547 catalytic residue [active] 331271017548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271017549 DNA-binding site [nucleotide binding]; DNA binding site 331271017550 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271017551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271017552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271017553 homodimer interface [polypeptide binding]; other site 331271017554 catalytic residue [active] 331271017555 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 331271017556 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 331271017557 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271017558 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271017559 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271017560 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271017561 active site 331271017562 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 331271017563 Uncharacterized conserved protein [Function unknown]; Region: COG3777 331271017564 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 331271017565 active site 2 [active] 331271017566 active site 1 [active] 331271017567 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271017568 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 331271017569 Fusaric acid resistance protein family; Region: FUSC; pfam04632 331271017570 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 331271017571 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 331271017572 TOBE domain; Region: TOBE; cl01440 331271017573 TOBE domain; Region: TOBE; cl01440 331271017574 NifQ; Region: NifQ; pfam04891 331271017575 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331271017576 ProQ/FINO family; Region: ProQ; pfam04352 331271017577 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 331271017578 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 331271017579 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 331271017580 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331271017581 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 331271017582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271017583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271017584 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 331271017585 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 331271017586 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 331271017587 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 331271017588 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271017589 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017590 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331271017591 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331271017592 P-loop; other site 331271017593 Magnesium ion binding site [ion binding]; other site 331271017594 ParB-like nuclease domain; Region: ParB; smart00470 331271017595 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 331271017596 Initiator Replication protein; Region: Rep_3; pfam01051 331271017597 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271017598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017599 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271017600 dimerization interface [polypeptide binding]; other site 331271017601 substrate binding pocket [chemical binding]; other site 331271017602 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 331271017603 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 331271017604 GDP-binding site [chemical binding]; other site 331271017605 ACT binding site; other site 331271017606 IMP binding site; other site 331271017607 transcriptional regulator; Provisional; Region: PRK10632 331271017608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017609 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271017610 putative effector binding pocket; other site 331271017611 dimerization interface [polypeptide binding]; other site 331271017612 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271017613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271017614 substrate binding pocket [chemical binding]; other site 331271017615 membrane-bound complex binding site; other site 331271017616 hinge residues; other site 331271017617 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 331271017618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017619 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271017620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017621 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 331271017622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017623 dimerization interface [polypeptide binding]; other site 331271017624 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 331271017625 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331271017626 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271017627 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 331271017628 Protein export membrane protein; Region: SecD_SecF; cl14618 331271017629 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271017630 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 331271017631 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271017632 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 331271017633 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 331271017634 conserved cys residue [active] 331271017635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331271017638 Zn2+ binding site [ion binding]; other site 331271017639 Mg2+ binding site [ion binding]; other site 331271017640 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 331271017641 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 331271017642 RES domain; Region: RES; pfam08808 331271017643 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 331271017644 active site 331271017645 Int/Topo IB signature motif; other site 331271017646 catalytic residues [active] 331271017647 DNA binding site [nucleotide binding] 331271017648 Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933 331271017649 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 331271017650 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 331271017651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271017652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017653 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017654 dimerization interface [polypeptide binding]; other site 331271017655 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 331271017656 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 331271017657 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 331271017658 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 331271017659 active site 331271017660 metal binding site [ion binding]; metal-binding site 331271017661 DNA binding site [nucleotide binding] 331271017662 P-loop containing region of AAA domain; Region: AAA_29; cl17516 331271017663 AAA domain; Region: AAA_27; pfam13514 331271017664 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 331271017665 HD domain; Region: HD_4; pfam13328 331271017666 Protein of unknown function (DUF429); Region: DUF429; pfam04250 331271017667 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 331271017668 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 331271017669 DNA binding residues [nucleotide binding] 331271017670 dimer interface [polypeptide binding]; other site 331271017671 copper binding site [ion binding]; other site 331271017672 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 331271017673 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 331271017674 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 331271017675 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271017676 active site 331271017677 catalytic tetrad [active] 331271017678 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 331271017679 classical (c) SDRs; Region: SDR_c; cd05233 331271017680 NAD(P) binding site [chemical binding]; other site 331271017681 active site 331271017682 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 331271017683 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271017684 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271017685 homodimer interface [polypeptide binding]; other site 331271017686 catalytic residue [active] 331271017687 excinuclease ABC subunit B; Provisional; Region: PRK05298 331271017688 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331271017689 ATP binding site [chemical binding]; other site 331271017690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271017691 nucleotide binding region [chemical binding]; other site 331271017692 ATP-binding site [chemical binding]; other site 331271017693 Ultra-violet resistance protein B; Region: UvrB; pfam12344 331271017694 UvrB/uvrC motif; Region: UVR; pfam02151 331271017695 Fe2+ transport protein; Region: Iron_transport; pfam10634 331271017696 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 331271017697 Iron permease FTR1 family; Region: FTR1; cl00475 331271017698 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 331271017699 4Fe-4S binding domain; Region: Fer4_5; pfam12801 331271017700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 331271017701 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271017702 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271017703 Hemin uptake protein hemP; Region: hemP; pfam10636 331271017704 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 331271017705 putative hydrophobic ligand binding site [chemical binding]; other site 331271017706 Pirin-related protein [General function prediction only]; Region: COG1741 331271017707 Pirin; Region: Pirin; pfam02678 331271017708 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 331271017709 LysR family transcriptional regulator; Provisional; Region: PRK14997 331271017710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017711 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 331271017712 putative effector binding pocket; other site 331271017713 putative dimerization interface [polypeptide binding]; other site 331271017714 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 331271017715 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 331271017716 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 331271017717 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 331271017718 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 331271017719 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 331271017720 glutamate racemase; Provisional; Region: PRK00865 331271017721 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 331271017722 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 331271017723 heme binding site [chemical binding]; other site 331271017724 ferroxidase pore; other site 331271017725 ferroxidase diiron center [ion binding]; other site 331271017726 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 331271017727 Fumarase C-terminus; Region: Fumerase_C; pfam05683 331271017728 hypothetical protein; Provisional; Region: PRK05208 331271017729 EamA-like transporter family; Region: EamA; pfam00892 331271017730 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 331271017731 EamA-like transporter family; Region: EamA; pfam00892 331271017732 acetyl-CoA synthetase; Provisional; Region: PRK00174 331271017733 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 331271017734 active site 331271017735 CoA binding site [chemical binding]; other site 331271017736 acyl-activating enzyme (AAE) consensus motif; other site 331271017737 AMP binding site [chemical binding]; other site 331271017738 acetate binding site [chemical binding]; other site 331271017739 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 331271017740 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 331271017741 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 331271017742 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 331271017743 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271017744 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271017745 N-terminal plug; other site 331271017746 ligand-binding site [chemical binding]; other site 331271017747 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 331271017748 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 331271017749 Fatty acid desaturase; Region: FA_desaturase; pfam00487 331271017750 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 331271017751 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271017752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271017753 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 331271017754 D-galactonate transporter; Region: 2A0114; TIGR00893 331271017755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271017756 putative substrate translocation pore; other site 331271017757 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 331271017758 DNA photolyase; Region: DNA_photolyase; pfam00875 331271017759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271017760 putative substrate translocation pore; other site 331271017761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271017762 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 331271017763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017764 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017765 dimerization interface [polypeptide binding]; other site 331271017766 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 331271017767 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271017768 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 331271017769 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 331271017770 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271017771 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271017772 substrate binding pocket [chemical binding]; other site 331271017773 membrane-bound complex binding site; other site 331271017774 hinge residues; other site 331271017775 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 331271017776 active sites [active] 331271017777 tetramer interface [polypeptide binding]; other site 331271017778 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 331271017779 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271017780 DNA-binding site [nucleotide binding]; DNA binding site 331271017781 UTRA domain; Region: UTRA; pfam07702 331271017782 urocanate hydratase; Provisional; Region: PRK05414 331271017783 HutD; Region: HutD; pfam05962 331271017784 imidazolonepropionase; Validated; Region: PRK09356 331271017785 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 331271017786 active site 331271017787 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 331271017788 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 331271017789 active site 331271017790 N-formylglutamate amidohydrolase; Region: FGase; cl01522 331271017791 Peptidase C26; Region: Peptidase_C26; pfam07722 331271017792 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 331271017793 catalytic triad [active] 331271017794 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 331271017795 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 331271017796 putative aminotransferase; Validated; Region: PRK07480 331271017797 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271017798 inhibitor-cofactor binding pocket; inhibition site 331271017799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271017800 catalytic residue [active] 331271017801 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 331271017802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271017803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 331271017804 dimerization interface [polypeptide binding]; other site 331271017805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271017806 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271017807 active site 331271017808 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271017809 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271017810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271017811 metabolite-proton symporter; Region: 2A0106; TIGR00883 331271017812 putative substrate translocation pore; other site 331271017813 oxidative damage protection protein; Provisional; Region: PRK05408 331271017814 N-acetylglutamate synthase; Validated; Region: PRK05279 331271017815 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 331271017816 putative feedback inhibition sensing region; other site 331271017817 putative nucleotide binding site [chemical binding]; other site 331271017818 putative substrate binding site [chemical binding]; other site 331271017819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271017820 Coenzyme A binding pocket [chemical binding]; other site 331271017821 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 331271017822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331271017823 ATP binding site [chemical binding]; other site 331271017824 putative Mg++ binding site [ion binding]; other site 331271017825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271017826 nucleotide binding region [chemical binding]; other site 331271017827 ATP-binding site [chemical binding]; other site 331271017828 Helicase associated domain (HA2); Region: HA2; pfam04408 331271017829 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 331271017830 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 331271017831 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 331271017832 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 331271017833 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 331271017834 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 331271017835 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 331271017836 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 331271017837 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 331271017838 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 331271017839 putative MPT binding site; other site 331271017840 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 331271017841 active site residue [active] 331271017842 glutamine synthetase; Provisional; Region: glnA; PRK09469 331271017843 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 331271017844 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 331271017845 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 331271017846 PAS domain; Region: PAS; smart00091 331271017847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271017848 dimer interface [polypeptide binding]; other site 331271017849 phosphorylation site [posttranslational modification] 331271017850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271017851 ATP binding site [chemical binding]; other site 331271017852 Mg2+ binding site [ion binding]; other site 331271017853 G-X-G motif; other site 331271017854 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 331271017855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271017856 active site 331271017857 phosphorylation site [posttranslational modification] 331271017858 intermolecular recognition site; other site 331271017859 dimerization interface [polypeptide binding]; other site 331271017860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271017861 Walker A motif; other site 331271017862 ATP binding site [chemical binding]; other site 331271017863 Walker B motif; other site 331271017864 arginine finger; other site 331271017865 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271017866 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 331271017867 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331271017868 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 331271017869 putative catalytic site [active] 331271017870 putative phosphate binding site [ion binding]; other site 331271017871 active site 331271017872 metal binding site A [ion binding]; metal-binding site 331271017873 DNA binding site [nucleotide binding] 331271017874 putative AP binding site [nucleotide binding]; other site 331271017875 putative metal binding site B [ion binding]; other site 331271017876 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 331271017877 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 331271017878 aspartate racemase; Region: asp_race; TIGR00035 331271017879 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 331271017880 active site 331271017881 DNA polymerase IV; Validated; Region: PRK02406 331271017882 DNA binding site [nucleotide binding] 331271017883 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 331271017884 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 331271017885 active site 331271017886 Zn binding site [ion binding]; other site 331271017887 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 331271017888 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 331271017889 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 331271017890 homodimer interface [polypeptide binding]; other site 331271017891 NADP binding site [chemical binding]; other site 331271017892 substrate binding site [chemical binding]; other site 331271017893 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 331271017894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271017895 active site 331271017896 phosphorylation site [posttranslational modification] 331271017897 intermolecular recognition site; other site 331271017898 dimerization interface [polypeptide binding]; other site 331271017899 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271017900 DNA binding residues [nucleotide binding] 331271017901 dimerization interface [polypeptide binding]; other site 331271017902 PAS domain S-box; Region: sensory_box; TIGR00229 331271017903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271017904 putative active site [active] 331271017905 heme pocket [chemical binding]; other site 331271017906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271017907 dimer interface [polypeptide binding]; other site 331271017908 phosphorylation site [posttranslational modification] 331271017909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271017910 ATP binding site [chemical binding]; other site 331271017911 Mg2+ binding site [ion binding]; other site 331271017912 G-X-G motif; other site 331271017913 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 331271017914 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 331271017915 dimer interface [polypeptide binding]; other site 331271017916 TPP-binding site [chemical binding]; other site 331271017917 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 331271017918 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 331271017919 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271017920 E3 interaction surface; other site 331271017921 lipoyl attachment site [posttranslational modification]; other site 331271017922 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271017923 E3 interaction surface; other site 331271017924 lipoyl attachment site [posttranslational modification]; other site 331271017925 e3 binding domain; Region: E3_binding; pfam02817 331271017926 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 331271017927 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271017928 E3 interaction surface; other site 331271017929 lipoyl attachment site [posttranslational modification]; other site 331271017930 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 331271017931 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271017932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331271017933 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331271017934 Phasin protein; Region: Phasin_2; pfam09361 331271017935 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 331271017936 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 331271017937 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271017938 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271017939 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271017940 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331271017941 Cysteine-rich domain; Region: CCG; pfam02754 331271017942 Cysteine-rich domain; Region: CCG; pfam02754 331271017943 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 331271017944 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 331271017945 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331271017946 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 331271017947 Low molecular weight phosphatase family; Region: LMWPc; cd00115 331271017948 active site 331271017949 Predicted transcriptional regulator [Transcription]; Region: COG1959 331271017950 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 331271017951 cysteine desulfurase; Provisional; Region: PRK14012 331271017952 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 331271017953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271017954 catalytic residue [active] 331271017955 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 331271017956 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 331271017957 trimerization site [polypeptide binding]; other site 331271017958 active site 331271017959 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 331271017960 co-chaperone HscB; Provisional; Region: hscB; PRK03578 331271017961 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 331271017962 HSP70 interaction site [polypeptide binding]; other site 331271017963 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 331271017964 chaperone protein HscA; Provisional; Region: hscA; PRK05183 331271017965 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 331271017966 nucleotide binding site [chemical binding]; other site 331271017967 putative NEF/HSP70 interaction site [polypeptide binding]; other site 331271017968 SBD interface [polypeptide binding]; other site 331271017969 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 331271017970 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331271017971 catalytic loop [active] 331271017972 iron binding site [ion binding]; other site 331271017973 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 331271017974 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 331271017975 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 331271017976 dimer interface [polypeptide binding]; other site 331271017977 putative anticodon binding site; other site 331271017978 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 331271017979 motif 1; other site 331271017980 active site 331271017981 motif 2; other site 331271017982 motif 3; other site 331271017983 peptide chain release factor 2; Validated; Region: prfB; PRK00578 331271017984 This domain is found in peptide chain release factors; Region: PCRF; smart00937 331271017985 RF-1 domain; Region: RF-1; pfam00472 331271017986 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 331271017987 DHH family; Region: DHH; pfam01368 331271017988 DHHA1 domain; Region: DHHA1; pfam02272 331271017989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 331271017990 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 331271017991 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331271017992 FtsX-like permease family; Region: FtsX; pfam02687 331271017993 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 331271017994 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331271017995 Walker A/P-loop; other site 331271017996 ATP binding site [chemical binding]; other site 331271017997 Q-loop/lid; other site 331271017998 ABC transporter signature motif; other site 331271017999 Walker B; other site 331271018000 D-loop; other site 331271018001 H-loop/switch region; other site 331271018002 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 331271018003 active site 331271018004 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 331271018005 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 331271018006 Competence protein; Region: Competence; pfam03772 331271018007 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 331271018008 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 331271018009 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271018010 CTP synthetase; Validated; Region: pyrG; PRK05380 331271018011 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 331271018012 Catalytic site [active] 331271018013 active site 331271018014 UTP binding site [chemical binding]; other site 331271018015 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 331271018016 active site 331271018017 putative oxyanion hole; other site 331271018018 catalytic triad [active] 331271018019 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 331271018020 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331271018021 enolase; Provisional; Region: eno; PRK00077 331271018022 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 331271018023 dimer interface [polypeptide binding]; other site 331271018024 metal binding site [ion binding]; metal-binding site 331271018025 substrate binding pocket [chemical binding]; other site 331271018026 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 331271018027 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 331271018028 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 331271018029 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 331271018030 dimerization interface [polypeptide binding]; other site 331271018031 domain crossover interface; other site 331271018032 redox-dependent activation switch; other site 331271018033 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 331271018034 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 331271018035 trimer interface [polypeptide binding]; other site 331271018036 putative metal binding site [ion binding]; other site 331271018037 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 331271018038 dinuclear metal binding motif [ion binding]; other site 331271018039 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331271018040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271018041 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271018042 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 331271018043 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 331271018044 active site 331271018045 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 331271018046 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 331271018047 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 331271018048 Peptidase family M50; Region: Peptidase_M50; pfam02163 331271018049 active site 331271018050 putative substrate binding region [chemical binding]; other site 331271018051 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 331271018052 active site 331271018053 HIGH motif; other site 331271018054 dimer interface [polypeptide binding]; other site 331271018055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331271018056 active site 331271018057 KMSKS motif; other site 331271018058 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 331271018059 dihydrodipicolinate synthase; Region: dapA; TIGR00674 331271018060 dimer interface [polypeptide binding]; other site 331271018061 active site 331271018062 catalytic residue [active] 331271018063 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 331271018064 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 331271018065 Cupin superfamily protein; Region: Cupin_4; pfam08007 331271018066 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 331271018067 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 331271018068 MutS domain I; Region: MutS_I; pfam01624 331271018069 MutS domain II; Region: MutS_II; pfam05188 331271018070 MutS domain III; Region: MutS_III; pfam05192 331271018071 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 331271018072 Walker A/P-loop; other site 331271018073 ATP binding site [chemical binding]; other site 331271018074 Q-loop/lid; other site 331271018075 ABC transporter signature motif; other site 331271018076 Walker B; other site 331271018077 D-loop; other site 331271018078 H-loop/switch region; other site 331271018079 EthD domain; Region: EthD; cl17553 331271018080 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 331271018081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331271018082 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 331271018083 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 331271018084 active site 331271018085 dimerization interface [polypeptide binding]; other site 331271018086 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 331271018087 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 331271018088 serine O-acetyltransferase; Region: cysE; TIGR01172 331271018089 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 331271018090 trimer interface [polypeptide binding]; other site 331271018091 active site 331271018092 substrate binding site [chemical binding]; other site 331271018093 CoA binding site [chemical binding]; other site 331271018094 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331271018095 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 331271018096 putative active site [active] 331271018097 putative metal binding site [ion binding]; other site 331271018098 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 331271018099 substrate binding site [chemical binding]; other site 331271018100 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 331271018101 substrate binding site [chemical binding]; other site 331271018102 TPR repeat; Region: TPR_11; pfam13414 331271018103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331271018104 binding surface 331271018105 TPR motif; other site 331271018106 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 331271018107 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 331271018108 active site 331271018109 HIGH motif; other site 331271018110 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 331271018111 KMSKS motif; other site 331271018112 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 331271018113 tRNA binding surface [nucleotide binding]; other site 331271018114 anticodon binding site; other site 331271018115 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331271018116 endonuclease III; Region: ENDO3c; smart00478 331271018117 minor groove reading motif; other site 331271018118 helix-hairpin-helix signature motif; other site 331271018119 substrate binding pocket [chemical binding]; other site 331271018120 active site 331271018121 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 331271018122 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 331271018123 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 331271018124 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 331271018125 Ligand Binding Site [chemical binding]; other site 331271018126 TilS substrate binding domain; Region: TilS; pfam09179 331271018127 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 331271018128 aspartate kinase; Reviewed; Region: PRK06635 331271018129 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 331271018130 putative nucleotide binding site [chemical binding]; other site 331271018131 putative catalytic residues [active] 331271018132 putative Mg ion binding site [ion binding]; other site 331271018133 putative aspartate binding site [chemical binding]; other site 331271018134 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 331271018135 putative allosteric regulatory site; other site 331271018136 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 331271018137 galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288 331271018138 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 331271018139 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331271018140 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 331271018141 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 331271018142 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 331271018143 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 331271018144 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 331271018145 D-pathway; other site 331271018146 Putative ubiquinol binding site [chemical binding]; other site 331271018147 Low-spin heme (heme b) binding site [chemical binding]; other site 331271018148 Putative water exit pathway; other site 331271018149 Binuclear center (heme o3/CuB) [ion binding]; other site 331271018150 K-pathway; other site 331271018151 Putative proton exit pathway; other site 331271018152 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 331271018153 Subunit I/III interface [polypeptide binding]; other site 331271018154 Subunit III/IV interface [polypeptide binding]; other site 331271018155 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 331271018156 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 331271018157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331271018158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271018159 active site 331271018160 phosphorylation site [posttranslational modification] 331271018161 intermolecular recognition site; other site 331271018162 dimerization interface [polypeptide binding]; other site 331271018163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271018164 DNA binding site [nucleotide binding] 331271018165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331271018166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331271018167 dimerization interface [polypeptide binding]; other site 331271018168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271018169 dimer interface [polypeptide binding]; other site 331271018170 phosphorylation site [posttranslational modification] 331271018171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271018172 ATP binding site [chemical binding]; other site 331271018173 Mg2+ binding site [ion binding]; other site 331271018174 G-X-G motif; other site 331271018175 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 331271018176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271018177 DNA binding site [nucleotide binding] 331271018178 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 331271018179 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 331271018180 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 331271018181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271018182 dimer interface [polypeptide binding]; other site 331271018183 conserved gate region; other site 331271018184 putative PBP binding loops; other site 331271018185 ABC-ATPase subunit interface; other site 331271018186 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 331271018187 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 331271018188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271018189 dimer interface [polypeptide binding]; other site 331271018190 conserved gate region; other site 331271018191 putative PBP binding loops; other site 331271018192 ABC-ATPase subunit interface; other site 331271018193 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 331271018194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271018195 Walker A/P-loop; other site 331271018196 ATP binding site [chemical binding]; other site 331271018197 Q-loop/lid; other site 331271018198 ABC transporter signature motif; other site 331271018199 Walker B; other site 331271018200 D-loop; other site 331271018201 H-loop/switch region; other site 331271018202 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271018203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271018204 Walker A/P-loop; other site 331271018205 ATP binding site [chemical binding]; other site 331271018206 Q-loop/lid; other site 331271018207 ABC transporter signature motif; other site 331271018208 Walker B; other site 331271018209 D-loop; other site 331271018210 H-loop/switch region; other site 331271018211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271018212 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 331271018213 NlpC/P60 family; Region: NLPC_P60; pfam00877 331271018214 hypothetical protein; Provisional; Region: PRK10279 331271018215 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 331271018216 nucleophile elbow; other site 331271018217 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 331271018218 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331271018219 active site 331271018220 HIGH motif; other site 331271018221 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331271018222 active site 331271018223 KMSKS motif; other site 331271018224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271018225 Coenzyme A binding pocket [chemical binding]; other site 331271018226 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 331271018227 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 331271018228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271018229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271018230 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 331271018231 putative active site pocket [active] 331271018232 dimerization interface [polypeptide binding]; other site 331271018233 putative catalytic residue [active] 331271018234 malate synthase A; Region: malate_syn_A; TIGR01344 331271018235 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 331271018236 active site 331271018237 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 331271018238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271018239 motif II; other site 331271018240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271018241 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271018242 putative effector binding pocket; other site 331271018243 dimerization interface [polypeptide binding]; other site 331271018244 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331271018245 Ligand Binding Site [chemical binding]; other site 331271018246 isocitrate lyase; Provisional; Region: PRK15063 331271018247 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 331271018248 tetramer interface [polypeptide binding]; other site 331271018249 active site 331271018250 Mg2+/Mn2+ binding site [ion binding]; other site 331271018251 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331271018252 DEAD-like helicases superfamily; Region: DEXDc; smart00487 331271018253 ATP binding site [chemical binding]; other site 331271018254 Mg++ binding site [ion binding]; other site 331271018255 motif III; other site 331271018256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271018257 nucleotide binding region [chemical binding]; other site 331271018258 ATP-binding site [chemical binding]; other site 331271018259 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 331271018260 acyl-CoA binding pocket [chemical binding]; other site 331271018261 CoA binding site [chemical binding]; other site 331271018262 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 331271018263 Glycoprotease family; Region: Peptidase_M22; pfam00814 331271018264 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 331271018265 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 331271018266 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 331271018267 Fe-S cluster binding site [ion binding]; other site 331271018268 active site 331271018269 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 331271018270 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 331271018271 dimer interface [polypeptide binding]; other site 331271018272 substrate binding site [chemical binding]; other site 331271018273 ATP binding site [chemical binding]; other site 331271018274 lysophospholipid transporter LplT; Provisional; Region: PRK11195 331271018275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271018276 alanine racemase; Reviewed; Region: dadX; PRK03646 331271018277 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 331271018278 active site 331271018279 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331271018280 substrate binding site [chemical binding]; other site 331271018281 catalytic residues [active] 331271018282 dimer interface [polypeptide binding]; other site 331271018283 DNA repair protein RadA; Provisional; Region: PRK11823 331271018284 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 331271018285 Walker A motif/ATP binding site; other site 331271018286 ATP binding site [chemical binding]; other site 331271018287 Walker B motif; other site 331271018288 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 331271018289 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 331271018290 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 331271018291 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271018292 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271018293 ABC transporter; Region: ABC_tran_2; pfam12848 331271018294 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271018295 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 331271018296 catalytic residues [active] 331271018297 dimer interface [polypeptide binding]; other site 331271018298 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 331271018299 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331271018300 putative active site [active] 331271018301 catalytic site [active] 331271018302 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 331271018303 putative active site [active] 331271018304 catalytic site [active] 331271018305 HemK family putative methylases; Region: hemK_fam; TIGR00536 331271018306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271018307 S-adenosylmethionine binding site [chemical binding]; other site 331271018308 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 331271018309 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 331271018310 metal binding site [ion binding]; metal-binding site 331271018311 dimer interface [polypeptide binding]; other site 331271018312 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 331271018313 ArsC family; Region: ArsC; pfam03960 331271018314 putative catalytic residues [active] 331271018315 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 331271018316 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 331271018317 trimer interface [polypeptide binding]; other site 331271018318 active site 331271018319 substrate binding site [chemical binding]; other site 331271018320 CoA binding site [chemical binding]; other site 331271018321 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 331271018322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271018323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271018324 homodimer interface [polypeptide binding]; other site 331271018325 catalytic residue [active] 331271018326 Probable transposase; Region: OrfB_IS605; pfam01385 331271018327 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 331271018328 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 331271018329 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331271018330 EamA-like transporter family; Region: EamA; pfam00892 331271018331 EamA-like transporter family; Region: EamA; pfam00892 331271018332 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 331271018333 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 331271018334 Walker A/P-loop; other site 331271018335 ATP binding site [chemical binding]; other site 331271018336 Q-loop/lid; other site 331271018337 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 331271018338 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 331271018339 Q-loop/lid; other site 331271018340 ABC transporter signature motif; other site 331271018341 Walker B; other site 331271018342 D-loop; other site 331271018343 H-loop/switch region; other site 331271018344 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 331271018345 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 331271018346 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 331271018347 nucleotide binding pocket [chemical binding]; other site 331271018348 K-X-D-G motif; other site 331271018349 catalytic site [active] 331271018350 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 331271018351 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 331271018352 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 331271018353 Dimer interface [polypeptide binding]; other site 331271018354 BRCT sequence motif; other site 331271018355 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 331271018356 active site 331271018357 catalytic residues [active] 331271018358 metal binding site [ion binding]; metal-binding site 331271018359 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 331271018360 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331271018361 RNA binding surface [nucleotide binding]; other site 331271018362 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 331271018363 active site 331271018364 PII uridylyl-transferase; Provisional; Region: PRK03059 331271018365 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 331271018366 metal binding triad; other site 331271018367 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 331271018368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331271018369 Zn2+ binding site [ion binding]; other site 331271018370 Mg2+ binding site [ion binding]; other site 331271018371 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 331271018372 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 331271018373 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 331271018374 active site 331271018375 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 331271018376 rRNA interaction site [nucleotide binding]; other site 331271018377 S8 interaction site; other site 331271018378 putative laminin-1 binding site; other site 331271018379 elongation factor Ts; Provisional; Region: tsf; PRK09377 331271018380 UBA/TS-N domain; Region: UBA; pfam00627 331271018381 Elongation factor TS; Region: EF_TS; pfam00889 331271018382 Elongation factor TS; Region: EF_TS; pfam00889 331271018383 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 331271018384 putative nucleotide binding site [chemical binding]; other site 331271018385 uridine monophosphate binding site [chemical binding]; other site 331271018386 homohexameric interface [polypeptide binding]; other site 331271018387 ribosome recycling factor; Reviewed; Region: frr; PRK00083 331271018388 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 331271018389 hinge region; other site 331271018390 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 331271018391 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 331271018392 catalytic residue [active] 331271018393 putative FPP diphosphate binding site; other site 331271018394 putative FPP binding hydrophobic cleft; other site 331271018395 dimer interface [polypeptide binding]; other site 331271018396 putative IPP diphosphate binding site; other site 331271018397 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 331271018398 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 331271018399 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 331271018400 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 331271018401 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 331271018402 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 331271018403 zinc metallopeptidase RseP; Provisional; Region: PRK10779 331271018404 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 331271018405 active site 331271018406 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 331271018407 protein binding site [polypeptide binding]; other site 331271018408 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 331271018409 putative substrate binding region [chemical binding]; other site 331271018410 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 331271018411 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331271018412 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331271018413 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331271018414 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331271018415 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331271018416 Surface antigen; Region: Bac_surface_Ag; pfam01103 331271018417 periplasmic chaperone; Provisional; Region: PRK10780 331271018418 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 331271018419 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 331271018420 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 331271018421 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 331271018422 trimer interface [polypeptide binding]; other site 331271018423 active site 331271018424 UDP-GlcNAc binding site [chemical binding]; other site 331271018425 lipid binding site [chemical binding]; lipid-binding site 331271018426 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 331271018427 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 331271018428 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 331271018429 active site 331271018430 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 331271018431 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 331271018432 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 331271018433 RNA/DNA hybrid binding site [nucleotide binding]; other site 331271018434 active site 331271018435 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 331271018436 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 331271018437 PEP synthetase regulatory protein; Provisional; Region: PRK05339 331271018438 phosphoenolpyruvate synthase; Validated; Region: PRK06464 331271018439 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 331271018440 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 331271018441 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 331271018442 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331271018443 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 331271018444 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 331271018445 SmpB-tmRNA interface; other site 331271018446 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 331271018447 putative coenzyme Q binding site [chemical binding]; other site 331271018448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 331271018449 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 331271018450 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 331271018451 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 331271018452 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 331271018453 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 331271018454 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 331271018455 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 331271018456 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 331271018457 active site 331271018458 GMP synthase; Reviewed; Region: guaA; PRK00074 331271018459 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 331271018460 AMP/PPi binding site [chemical binding]; other site 331271018461 candidate oxyanion hole; other site 331271018462 catalytic triad [active] 331271018463 potential glutamine specificity residues [chemical binding]; other site 331271018464 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 331271018465 ATP Binding subdomain [chemical binding]; other site 331271018466 Ligand Binding sites [chemical binding]; other site 331271018467 Dimerization subdomain; other site 331271018468 DinB family; Region: DinB; cl17821 331271018469 DinB superfamily; Region: DinB_2; pfam12867 331271018470 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 331271018471 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 331271018472 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 331271018473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271018474 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 331271018475 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271018476 DNA-binding site [nucleotide binding]; DNA binding site 331271018477 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271018478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271018479 homodimer interface [polypeptide binding]; other site 331271018480 catalytic residue [active] 331271018481 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331271018482 active site 331271018483 catalytic site [active] 331271018484 substrate binding site [chemical binding]; other site 331271018485 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 331271018486 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331271018487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271018488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331271018489 Coenzyme A binding pocket [chemical binding]; other site 331271018490 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 331271018491 nudix motif; other site 331271018492 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271018493 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 331271018494 Protein of unknown function (DUF971); Region: DUF971; pfam06155 331271018495 HEAT repeats; Region: HEAT_2; pfam13646 331271018496 HEAT repeats; Region: HEAT_2; pfam13646 331271018497 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271018498 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271018499 Walker A/P-loop; other site 331271018500 ATP binding site [chemical binding]; other site 331271018501 Q-loop/lid; other site 331271018502 ABC transporter signature motif; other site 331271018503 Walker B; other site 331271018504 D-loop; other site 331271018505 H-loop/switch region; other site 331271018506 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271018507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271018508 dimer interface [polypeptide binding]; other site 331271018509 conserved gate region; other site 331271018510 putative PBP binding loops; other site 331271018511 ABC-ATPase subunit interface; other site 331271018512 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 331271018513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 331271018514 substrate binding pocket [chemical binding]; other site 331271018515 membrane-bound complex binding site; other site 331271018516 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 331271018517 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 331271018518 putative oxidoreductase; Provisional; Region: PRK08275 331271018519 L-aspartate oxidase; Provisional; Region: PRK06175 331271018520 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331271018521 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 331271018522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271018523 DNA-binding site [nucleotide binding]; DNA binding site 331271018524 UTRA domain; Region: UTRA; pfam07702 331271018525 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271018526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271018527 putative substrate translocation pore; other site 331271018528 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 331271018529 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 331271018530 nucleoside/Zn binding site; other site 331271018531 dimer interface [polypeptide binding]; other site 331271018532 catalytic motif [active] 331271018533 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 331271018534 dimer interface [polypeptide binding]; other site 331271018535 catalytic triad [active] 331271018536 Transcriptional regulators [Transcription]; Region: GntR; COG1802 331271018537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271018538 DNA-binding site [nucleotide binding]; DNA binding site 331271018539 FCD domain; Region: FCD; pfam07729 331271018540 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 331271018541 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 331271018542 Na binding site [ion binding]; other site 331271018543 putative substrate binding site [chemical binding]; other site 331271018544 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 331271018545 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 331271018546 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 331271018547 active site 331271018548 catalytic site [active] 331271018549 tetramer interface [polypeptide binding]; other site 331271018550 OHCU decarboxylase; Region: UHCUDC; TIGR03164 331271018551 allantoicase; Provisional; Region: PRK13257 331271018552 Allantoicase repeat; Region: Allantoicase; pfam03561 331271018553 Allantoicase repeat; Region: Allantoicase; pfam03561 331271018554 ureidoglycolate hydrolase; Provisional; Region: PRK03606 331271018555 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 331271018556 ACT domain; Region: ACT_3; pfam10000 331271018557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 331271018558 Predicted membrane protein [Function unknown]; Region: COG3748 331271018559 Protein of unknown function (DUF989); Region: DUF989; pfam06181 331271018560 Cytochrome c; Region: Cytochrom_C; pfam00034 331271018561 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 331271018562 active site 331271018563 homotetramer interface [polypeptide binding]; other site 331271018564 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 331271018565 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 331271018566 active site 331271018567 putative substrate binding pocket [chemical binding]; other site 331271018568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271018569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271018570 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 331271018571 putative substrate binding pocket [chemical binding]; other site 331271018572 putative dimerization interface [polypeptide binding]; other site 331271018573 Dodecin; Region: Dodecin; pfam07311 331271018574 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 331271018575 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271018576 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 331271018577 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 331271018578 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331271018579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 331271018580 TPR motif; other site 331271018581 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 331271018582 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 331271018583 Transglycosylase; Region: Transgly; pfam00912 331271018584 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331271018585 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 331271018586 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 331271018587 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 331271018588 tetramer interface [polypeptide binding]; other site 331271018589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271018590 catalytic residue [active] 331271018591 acetylornithine deacetylase; Provisional; Region: PRK07522 331271018592 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 331271018593 metal binding site [ion binding]; metal-binding site 331271018594 putative dimer interface [polypeptide binding]; other site 331271018595 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 331271018596 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 331271018597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331271018598 ATP binding site [chemical binding]; other site 331271018599 putative Mg++ binding site [ion binding]; other site 331271018600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331271018601 nucleotide binding region [chemical binding]; other site 331271018602 ATP-binding site [chemical binding]; other site 331271018603 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 331271018604 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 331271018605 substrate binding site; other site 331271018606 dimer interface; other site 331271018607 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 331271018608 homotrimer interaction site [polypeptide binding]; other site 331271018609 zinc binding site [ion binding]; other site 331271018610 CDP-binding sites; other site 331271018611 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 331271018612 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 331271018613 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 331271018614 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 331271018615 dimer interface [polypeptide binding]; other site 331271018616 decamer (pentamer of dimers) interface [polypeptide binding]; other site 331271018617 catalytic triad [active] 331271018618 peroxidatic and resolving cysteines [active] 331271018619 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 331271018620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271018621 dimer interface [polypeptide binding]; other site 331271018622 phosphorylation site [posttranslational modification] 331271018623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271018624 ATP binding site [chemical binding]; other site 331271018625 Mg2+ binding site [ion binding]; other site 331271018626 G-X-G motif; other site 331271018627 osmolarity response regulator; Provisional; Region: ompR; PRK09468 331271018628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271018629 active site 331271018630 phosphorylation site [posttranslational modification] 331271018631 intermolecular recognition site; other site 331271018632 dimerization interface [polypeptide binding]; other site 331271018633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331271018634 DNA binding site [nucleotide binding] 331271018635 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 331271018636 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 331271018637 YfhG lipoprotein; Region: Lipoprotein_20; cl08141 331271018638 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 331271018639 active site lid residues [active] 331271018640 substrate binding pocket [chemical binding]; other site 331271018641 catalytic residues [active] 331271018642 substrate-Mg2+ binding site; other site 331271018643 aspartate-rich region 1; other site 331271018644 aspartate-rich region 2; other site 331271018645 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 331271018646 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 331271018647 active site 331271018648 Zn binding site [ion binding]; other site 331271018649 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271018650 trimer interface [polypeptide binding]; other site 331271018651 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271018652 eyelet of channel; other site 331271018653 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271018654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271018655 dimerization interface [polypeptide binding]; other site 331271018656 DNA binding residues [nucleotide binding] 331271018657 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 331271018658 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 331271018659 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 331271018660 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331271018661 MarR family; Region: MarR_2; pfam12802 331271018662 MarR family; Region: MarR_2; cl17246 331271018663 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 331271018664 trigger factor; Provisional; Region: tig; PRK01490 331271018665 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 331271018666 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 331271018667 Clp protease; Region: CLP_protease; pfam00574 331271018668 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 331271018669 oligomer interface [polypeptide binding]; other site 331271018670 active site residues [active] 331271018671 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 331271018672 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 331271018673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271018674 Walker A motif; other site 331271018675 ATP binding site [chemical binding]; other site 331271018676 Walker B motif; other site 331271018677 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 331271018678 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 331271018679 Found in ATP-dependent protease La (LON); Region: LON; smart00464 331271018680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271018681 Walker A motif; other site 331271018682 ATP binding site [chemical binding]; other site 331271018683 Walker B motif; other site 331271018684 arginine finger; other site 331271018685 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 331271018686 SurA N-terminal domain; Region: SurA_N_3; cl07813 331271018687 periplasmic folding chaperone; Provisional; Region: PRK10788 331271018688 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 331271018689 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 331271018690 active site 331271018691 catalytic triad [active] 331271018692 oxyanion hole [active] 331271018693 switch loop; other site 331271018694 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 331271018695 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331271018696 Walker A/P-loop; other site 331271018697 ATP binding site [chemical binding]; other site 331271018698 Q-loop/lid; other site 331271018699 ABC transporter signature motif; other site 331271018700 Walker B; other site 331271018701 D-loop; other site 331271018702 H-loop/switch region; other site 331271018703 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 331271018704 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 331271018705 active site 331271018706 dimer interface [polypeptide binding]; other site 331271018707 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 331271018708 dimer interface [polypeptide binding]; other site 331271018709 active site 331271018710 putative carbohydrate kinase; Provisional; Region: PRK10565 331271018711 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 331271018712 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 331271018713 putative substrate binding site [chemical binding]; other site 331271018714 putative ATP binding site [chemical binding]; other site 331271018715 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 331271018716 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 331271018717 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 331271018718 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 331271018719 dimerization interface [polypeptide binding]; other site 331271018720 ATP binding site [chemical binding]; other site 331271018721 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 331271018722 dimerization interface [polypeptide binding]; other site 331271018723 ATP binding site [chemical binding]; other site 331271018724 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 331271018725 putative active site [active] 331271018726 catalytic triad [active] 331271018727 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271018728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271018729 Coenzyme A binding pocket [chemical binding]; other site 331271018730 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 331271018731 BolA-like protein; Region: BolA; pfam01722 331271018732 intracellular septation protein A; Reviewed; Region: PRK00259 331271018733 methionine sulfoxide reductase B; Provisional; Region: PRK00222 331271018734 SelR domain; Region: SelR; pfam01641 331271018735 Uncharacterized conserved protein [Function unknown]; Region: COG0397 331271018736 hypothetical protein; Validated; Region: PRK00029 331271018737 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 331271018738 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 331271018739 dimer interface [polypeptide binding]; other site 331271018740 acyl-activating enzyme (AAE) consensus motif; other site 331271018741 putative active site [active] 331271018742 AMP binding site [chemical binding]; other site 331271018743 putative CoA binding site [chemical binding]; other site 331271018744 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331271018745 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 331271018746 substrate binding site [chemical binding]; other site 331271018747 oxyanion hole (OAH) forming residues; other site 331271018748 trimer interface [polypeptide binding]; other site 331271018749 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 331271018750 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271018751 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 331271018752 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 331271018753 Isochorismatase family; Region: Isochorismatase; pfam00857 331271018754 catalytic triad [active] 331271018755 metal binding site [ion binding]; metal-binding site 331271018756 conserved cis-peptide bond; other site 331271018757 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 331271018758 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271018759 dimer interface [polypeptide binding]; other site 331271018760 active site 331271018761 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271018762 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271018763 metal binding site [ion binding]; metal-binding site 331271018764 active site 331271018765 I-site; other site 331271018766 Cache domain; Region: Cache_1; pfam02743 331271018767 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271018768 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271018769 metal binding site [ion binding]; metal-binding site 331271018770 active site 331271018771 I-site; other site 331271018772 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 331271018773 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 331271018774 CoenzymeA binding site [chemical binding]; other site 331271018775 subunit interaction site [polypeptide binding]; other site 331271018776 PHB binding site; other site 331271018777 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 331271018778 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 331271018779 substrate binding pocket [chemical binding]; other site 331271018780 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271018781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271018782 Coenzyme A binding pocket [chemical binding]; other site 331271018783 NRDE protein; Region: NRDE; cl01315 331271018784 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 331271018785 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 331271018786 YceG-like family; Region: YceG; pfam02618 331271018787 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 331271018788 dimerization interface [polypeptide binding]; other site 331271018789 thymidylate kinase; Validated; Region: tmk; PRK00698 331271018790 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 331271018791 TMP-binding site; other site 331271018792 ATP-binding site [chemical binding]; other site 331271018793 DNA polymerase III subunit delta'; Validated; Region: PRK06964 331271018794 DNA polymerase III subunit delta'; Validated; Region: PRK08485 331271018795 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 331271018796 active site 331271018797 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 331271018798 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 331271018799 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 331271018800 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331271018801 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331271018802 Predicted ATPase [General function prediction only]; Region: COG4637 331271018803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271018804 Walker A/P-loop; other site 331271018805 ATP binding site [chemical binding]; other site 331271018806 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 331271018807 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331271018808 putative ADP-binding pocket [chemical binding]; other site 331271018809 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 331271018810 Domain of unknown function DUF221; Region: DUF221; pfam02714 331271018811 psiF repeat; Region: PsiF_repeat; pfam07769 331271018812 psiF repeat; Region: PsiF_repeat; pfam07769 331271018813 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 331271018814 active site 331271018815 homodimer interface [polypeptide binding]; other site 331271018816 homotetramer interface [polypeptide binding]; other site 331271018817 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 331271018818 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331271018819 tartronate semialdehyde reductase; Provisional; Region: PRK15059 331271018820 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331271018821 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 331271018822 glyoxylate carboligase; Provisional; Region: PRK11269 331271018823 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331271018824 PYR/PP interface [polypeptide binding]; other site 331271018825 dimer interface [polypeptide binding]; other site 331271018826 TPP binding site [chemical binding]; other site 331271018827 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331271018828 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 331271018829 TPP-binding site [chemical binding]; other site 331271018830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271018831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271018832 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271018833 putative effector binding pocket; other site 331271018834 dimerization interface [polypeptide binding]; other site 331271018835 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 331271018836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271018837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271018838 DNA binding residues [nucleotide binding] 331271018839 Putative zinc-finger; Region: zf-HC2; pfam13490 331271018840 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 331271018841 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 331271018842 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 331271018843 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 331271018844 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 331271018845 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 331271018846 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 331271018847 replicative DNA helicase; Provisional; Region: PRK07004 331271018848 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 331271018849 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 331271018850 Walker A motif; other site 331271018851 ATP binding site [chemical binding]; other site 331271018852 Walker B motif; other site 331271018853 DNA binding loops [nucleotide binding] 331271018854 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 331271018855 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 331271018856 Transposase; Region: DEDD_Tnp_IS110; pfam01548 331271018857 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 331271018858 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 331271018859 NlpC/P60 family; Region: NLPC_P60; pfam00877 331271018860 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 331271018861 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 331271018862 putative active site [active] 331271018863 PhoH-like protein; Region: PhoH; pfam02562 331271018864 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 331271018865 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271018866 catalytic triad [active] 331271018867 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 331271018868 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 331271018869 putative active site [active] 331271018870 putative catalytic site [active] 331271018871 putative Zn binding site [ion binding]; other site 331271018872 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 331271018873 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 331271018874 NAD binding site [chemical binding]; other site 331271018875 substrate binding site [chemical binding]; other site 331271018876 active site 331271018877 putative formyltransferase; Provisional; Region: PRK06988 331271018878 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 331271018879 active site 331271018880 substrate binding site [chemical binding]; other site 331271018881 cosubstrate binding site; other site 331271018882 catalytic site [active] 331271018883 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 331271018884 active site 331271018885 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 331271018886 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 331271018887 Ligand binding site; other site 331271018888 Putative Catalytic site; other site 331271018889 DXD motif; other site 331271018890 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 331271018891 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 331271018892 inhibitor-cofactor binding pocket; inhibition site 331271018893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271018894 catalytic residue [active] 331271018895 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 331271018896 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 331271018897 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 331271018898 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 331271018899 aminotransferase AlaT; Validated; Region: PRK09265 331271018900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331271018901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271018902 homodimer interface [polypeptide binding]; other site 331271018903 catalytic residue [active] 331271018904 homoserine dehydrogenase; Provisional; Region: PRK06349 331271018905 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 331271018906 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 331271018907 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 331271018908 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 331271018909 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 331271018910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271018911 catalytic residue [active] 331271018912 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 331271018913 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 331271018914 dimer interface [polypeptide binding]; other site 331271018915 putative functional site; other site 331271018916 putative MPT binding site; other site 331271018917 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 331271018918 MoaE interaction surface [polypeptide binding]; other site 331271018919 MoeB interaction surface [polypeptide binding]; other site 331271018920 thiocarboxylated glycine; other site 331271018921 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 331271018922 MoaE homodimer interface [polypeptide binding]; other site 331271018923 MoaD interaction [polypeptide binding]; other site 331271018924 active site residues [active] 331271018925 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 331271018926 apolar tunnel; other site 331271018927 heme binding site [chemical binding]; other site 331271018928 dimerization interface [polypeptide binding]; other site 331271018929 Transcriptional regulator; Region: Rrf2; cl17282 331271018930 Rrf2 family protein; Region: rrf2_super; TIGR00738 331271018931 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 331271018932 Clp amino terminal domain; Region: Clp_N; pfam02861 331271018933 Clp amino terminal domain; Region: Clp_N; pfam02861 331271018934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271018935 Walker A motif; other site 331271018936 ATP binding site [chemical binding]; other site 331271018937 Walker B motif; other site 331271018938 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 331271018939 arginine finger; other site 331271018940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271018941 Walker A motif; other site 331271018942 ATP binding site [chemical binding]; other site 331271018943 Walker B motif; other site 331271018944 arginine finger; other site 331271018945 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 331271018946 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 331271018947 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 331271018948 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 331271018949 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 331271018950 DNA binding residues [nucleotide binding] 331271018951 putative dimer interface [polypeptide binding]; other site 331271018952 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 331271018953 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 331271018954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271018955 Walker A motif; other site 331271018956 ATP binding site [chemical binding]; other site 331271018957 Walker B motif; other site 331271018958 arginine finger; other site 331271018959 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331271018960 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 331271018961 ATP-NAD kinase; Region: NAD_kinase; pfam01513 331271018962 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 331271018963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271018964 NAD(P) binding site [chemical binding]; other site 331271018965 active site 331271018966 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 331271018967 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 331271018968 tetramer interface [polypeptide binding]; other site 331271018969 TPP-binding site [chemical binding]; other site 331271018970 heterodimer interface [polypeptide binding]; other site 331271018971 phosphorylation loop region [posttranslational modification] 331271018972 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 331271018973 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 331271018974 alpha subunit interface [polypeptide binding]; other site 331271018975 TPP binding site [chemical binding]; other site 331271018976 heterodimer interface [polypeptide binding]; other site 331271018977 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331271018978 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 331271018979 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331271018980 E3 interaction surface; other site 331271018981 lipoyl attachment site [posttranslational modification]; other site 331271018982 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331271018983 catalytic site [active] 331271018984 lipoyl synthase; Provisional; Region: PRK12928 331271018985 multidrug efflux protein; Reviewed; Region: PRK01766 331271018986 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 331271018987 cation binding site [ion binding]; other site 331271018988 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 331271018989 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 331271018990 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 331271018991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271018992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271018993 putative substrate translocation pore; other site 331271018994 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 331271018995 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331271018996 DNA binding residues [nucleotide binding] 331271018997 transcription termination factor Rho; Provisional; Region: rho; PRK09376 331271018998 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 331271018999 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 331271019000 RNA binding site [nucleotide binding]; other site 331271019001 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 331271019002 multimer interface [polypeptide binding]; other site 331271019003 Walker A motif; other site 331271019004 ATP binding site [chemical binding]; other site 331271019005 Walker B motif; other site 331271019006 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331271019007 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331271019008 catalytic residues [active] 331271019009 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 331271019010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271019011 Walker A motif; other site 331271019012 ATP binding site [chemical binding]; other site 331271019013 Walker B motif; other site 331271019014 arginine finger; other site 331271019015 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 331271019016 hypothetical protein; Validated; Region: PRK00153 331271019017 recombination protein RecR; Reviewed; Region: recR; PRK00076 331271019018 RecR protein; Region: RecR; pfam02132 331271019019 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 331271019020 putative active site [active] 331271019021 putative metal-binding site [ion binding]; other site 331271019022 tetramer interface [polypeptide binding]; other site 331271019023 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 331271019024 CoA-transferase family III; Region: CoA_transf_3; pfam02515 331271019025 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 331271019026 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 331271019027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271019028 S-adenosylmethionine binding site [chemical binding]; other site 331271019029 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331271019030 Peptidase family M23; Region: Peptidase_M23; pfam01551 331271019031 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 331271019032 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331271019033 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331271019034 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331271019035 DNA binding residues [nucleotide binding] 331271019036 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 331271019037 active site 331271019038 catalytic site [active] 331271019039 substrate binding site [chemical binding]; other site 331271019040 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 331271019041 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331271019042 putative catalytic site [active] 331271019043 putative metal binding site [ion binding]; other site 331271019044 putative phosphate binding site [ion binding]; other site 331271019045 putative catalytic site [active] 331271019046 putative phosphate binding site [ion binding]; other site 331271019047 putative metal binding site [ion binding]; other site 331271019048 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 331271019049 TRAM domain; Region: TRAM; cl01282 331271019050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331271019051 S-adenosylmethionine binding site [chemical binding]; other site 331271019052 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 331271019053 YccA-like proteins; Region: YccA_like; cd10433 331271019054 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 331271019055 active site 331271019056 multimer interface [polypeptide binding]; other site 331271019057 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 331271019058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271019059 FeS/SAM binding site; other site 331271019060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271019061 non-specific DNA binding site [nucleotide binding]; other site 331271019062 salt bridge; other site 331271019063 sequence-specific DNA binding site [nucleotide binding]; other site 331271019064 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 331271019065 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 331271019066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 331271019067 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 331271019068 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 331271019069 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 331271019070 dimer interface [polypeptide binding]; other site 331271019071 motif 1; other site 331271019072 active site 331271019073 motif 2; other site 331271019074 motif 3; other site 331271019075 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 331271019076 anticodon binding site; other site 331271019077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 331271019078 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 331271019079 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 331271019080 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 331271019081 Trp docking motif [polypeptide binding]; other site 331271019082 active site 331271019083 GTP-binding protein Der; Reviewed; Region: PRK00093 331271019084 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 331271019085 G1 box; other site 331271019086 GTP/Mg2+ binding site [chemical binding]; other site 331271019087 Switch I region; other site 331271019088 G2 box; other site 331271019089 Switch II region; other site 331271019090 G3 box; other site 331271019091 G4 box; other site 331271019092 G5 box; other site 331271019093 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 331271019094 G1 box; other site 331271019095 GTP/Mg2+ binding site [chemical binding]; other site 331271019096 Switch I region; other site 331271019097 G2 box; other site 331271019098 G3 box; other site 331271019099 Switch II region; other site 331271019100 G4 box; other site 331271019101 G5 box; other site 331271019102 bacterial Hfq-like; Region: Hfq; cd01716 331271019103 hexamer interface [polypeptide binding]; other site 331271019104 Sm1 motif; other site 331271019105 RNA binding site [nucleotide binding]; other site 331271019106 Sm2 motif; other site 331271019107 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 331271019108 HflK protein; Region: hflK; TIGR01933 331271019109 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331271019110 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 331271019111 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 331271019112 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 331271019113 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 331271019114 dimer interface [polypeptide binding]; other site 331271019115 motif 1; other site 331271019116 active site 331271019117 motif 2; other site 331271019118 motif 3; other site 331271019119 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 331271019120 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 331271019121 GDP-binding site [chemical binding]; other site 331271019122 ACT binding site; other site 331271019123 IMP binding site; other site 331271019124 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 331271019125 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331271019126 active site 331271019127 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 331271019128 potassium uptake protein; Region: kup; TIGR00794 331271019129 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 331271019130 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 331271019131 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 331271019132 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 331271019133 RNA binding site [nucleotide binding]; other site 331271019134 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 331271019135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 331271019136 DEAD_2; Region: DEAD_2; pfam06733 331271019137 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 331271019138 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 331271019139 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 331271019140 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 331271019141 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331271019142 RNA binding surface [nucleotide binding]; other site 331271019143 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 331271019144 active site 331271019145 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 331271019146 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 331271019147 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 331271019148 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 331271019149 putative acyltransferase; Provisional; Region: PRK05790 331271019150 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 331271019151 dimer interface [polypeptide binding]; other site 331271019152 active site 331271019153 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 331271019154 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 331271019155 NAD(P) binding site [chemical binding]; other site 331271019156 homotetramer interface [polypeptide binding]; other site 331271019157 homodimer interface [polypeptide binding]; other site 331271019158 active site 331271019159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 331271019160 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 331271019161 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 331271019162 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 331271019163 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 331271019164 RibD C-terminal domain; Region: RibD_C; cl17279 331271019165 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 331271019166 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 331271019167 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331271019168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271019169 FeS/SAM binding site; other site 331271019170 TRAM domain; Region: TRAM; cl01282 331271019171 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 331271019172 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271019173 substrate binding site [chemical binding]; other site 331271019174 ATP binding site [chemical binding]; other site 331271019175 cystathionine beta-lyase; Provisional; Region: PRK07050 331271019176 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331271019177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331271019178 catalytic residue [active] 331271019179 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 331271019180 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 331271019181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271019182 motif II; other site 331271019183 transcriptional activator TtdR; Provisional; Region: PRK09801 331271019184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271019185 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271019186 putative effector binding pocket; other site 331271019187 dimerization interface [polypeptide binding]; other site 331271019188 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 331271019189 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 331271019190 putative NAD(P) binding site [chemical binding]; other site 331271019191 dimer interface [polypeptide binding]; other site 331271019192 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 331271019193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271019194 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 331271019195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271019196 Walker A/P-loop; other site 331271019197 Walker A/P-loop; other site 331271019198 ATP binding site [chemical binding]; other site 331271019199 Q-loop/lid; other site 331271019200 ABC transporter signature motif; other site 331271019201 Walker B; other site 331271019202 D-loop; other site 331271019203 H-loop/switch region; other site 331271019204 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 331271019205 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 331271019206 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 331271019207 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 331271019208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271019209 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271019210 ABC transporter; Region: ABC_tran_2; pfam12848 331271019211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331271019212 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 331271019213 substrate binding site [chemical binding]; other site 331271019214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331271019215 FeS/SAM binding site; other site 331271019216 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 331271019217 Asparagine synthase; Region: Asn_synthase; pfam00733 331271019218 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 331271019219 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 331271019220 active site 331271019221 TDP-binding site; other site 331271019222 acceptor substrate-binding pocket; other site 331271019223 homodimer interface [polypeptide binding]; other site 331271019224 Cephalosporin hydroxylase; Region: CmcI; pfam04989 331271019225 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 331271019226 Phosphotransferase enzyme family; Region: APH; pfam01636 331271019227 active site 331271019228 substrate binding site [chemical binding]; other site 331271019229 ATP binding site [chemical binding]; other site 331271019230 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 331271019231 NodB motif; other site 331271019232 active site 331271019233 catalytic site [active] 331271019234 metal binding site [ion binding]; metal-binding site 331271019235 hypothetical protein; Provisional; Region: PRK11667 331271019236 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 331271019237 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271019238 NAD binding site [chemical binding]; other site 331271019239 catalytic residues [active] 331271019240 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 331271019241 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 331271019242 FMN binding site [chemical binding]; other site 331271019243 substrate binding site [chemical binding]; other site 331271019244 putative catalytic residue [active] 331271019245 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 331271019246 putative fimbrial outer membrane usher protein; Provisional; Region: PRK15304 331271019247 PapC N-terminal domain; Region: PapC_N; pfam13954 331271019248 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 331271019249 PapC C-terminal domain; Region: PapC_C; pfam13953 331271019250 putative fimbrial chaperone protein; Provisional; Region: PRK09918 331271019251 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 331271019252 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 331271019253 Predicted Fe-S protein [General function prediction only]; Region: COG3313 331271019254 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 331271019255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 331271019256 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 331271019257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271019258 Walker A/P-loop; other site 331271019259 ATP binding site [chemical binding]; other site 331271019260 Q-loop/lid; other site 331271019261 ABC transporter signature motif; other site 331271019262 Walker B; other site 331271019263 D-loop; other site 331271019264 H-loop/switch region; other site 331271019265 TOBE domain; Region: TOBE_2; pfam08402 331271019266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019267 dimer interface [polypeptide binding]; other site 331271019268 conserved gate region; other site 331271019269 putative PBP binding loops; other site 331271019270 ABC-ATPase subunit interface; other site 331271019271 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 331271019272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019273 dimer interface [polypeptide binding]; other site 331271019274 conserved gate region; other site 331271019275 putative PBP binding loops; other site 331271019276 ABC-ATPase subunit interface; other site 331271019277 Putative phosphatase (DUF442); Region: DUF442; cl17385 331271019278 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 331271019279 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 331271019280 PAS fold; Region: PAS_4; pfam08448 331271019281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331271019282 putative active site [active] 331271019283 heme pocket [chemical binding]; other site 331271019284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271019285 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331271019286 Walker A motif; other site 331271019287 ATP binding site [chemical binding]; other site 331271019288 Walker B motif; other site 331271019289 arginine finger; other site 331271019290 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 331271019291 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 331271019292 DNA binding residues [nucleotide binding] 331271019293 putative dimer interface [polypeptide binding]; other site 331271019294 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 331271019295 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 331271019296 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331271019297 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331271019298 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331271019299 HlyD family secretion protein; Region: HlyD_3; pfam13437 331271019300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 331271019301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271019302 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 331271019303 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 331271019304 Cl- selectivity filter; other site 331271019305 Cl- binding residues [ion binding]; other site 331271019306 pore gating glutamate residue; other site 331271019307 dimer interface [polypeptide binding]; other site 331271019308 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 331271019309 Predicted membrane protein [Function unknown]; Region: COG2855 331271019310 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271019311 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 331271019312 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 331271019313 putative dimerization interface [polypeptide binding]; other site 331271019314 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331271019315 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 331271019316 substrate binding site [chemical binding]; other site 331271019317 ATP binding site [chemical binding]; other site 331271019318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019319 D-galactonate transporter; Region: 2A0114; TIGR00893 331271019320 putative substrate translocation pore; other site 331271019321 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 331271019322 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 331271019323 dimerization interface [polypeptide binding]; other site 331271019324 ligand binding site [chemical binding]; other site 331271019325 NADP binding site [chemical binding]; other site 331271019326 catalytic site [active] 331271019327 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271019328 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271019329 DNA binding site [nucleotide binding] 331271019330 domain linker motif; other site 331271019331 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 331271019332 putative ligand binding site [chemical binding]; other site 331271019333 putative dimerization interface [polypeptide binding]; other site 331271019334 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 331271019335 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 331271019336 PGDYG protein; Region: PGDYG; pfam14083 331271019337 LTXXQ motif family protein; Region: LTXXQ; pfam07813 331271019338 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271019339 AsnC family; Region: AsnC_trans_reg; pfam01037 331271019340 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 331271019341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271019342 AAA domain; Region: AAA_33; pfam13671 331271019343 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 331271019344 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 331271019345 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 331271019346 oligomer interface [polypeptide binding]; other site 331271019347 metal binding site [ion binding]; metal-binding site 331271019348 metal binding site [ion binding]; metal-binding site 331271019349 putative Cl binding site [ion binding]; other site 331271019350 basic sphincter; other site 331271019351 hydrophobic gate; other site 331271019352 periplasmic entrance; other site 331271019353 YciI-like protein; Reviewed; Region: PRK12866 331271019354 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 331271019355 putative deacylase active site [active] 331271019356 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 331271019357 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 331271019358 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 331271019359 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 331271019360 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 331271019361 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 331271019362 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 331271019363 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 331271019364 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331271019365 non-specific DNA binding site [nucleotide binding]; other site 331271019366 salt bridge; other site 331271019367 sequence-specific DNA binding site [nucleotide binding]; other site 331271019368 Cupin domain; Region: Cupin_2; pfam07883 331271019369 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 331271019370 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 331271019371 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 331271019372 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 331271019373 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 331271019374 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 331271019375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019376 dimer interface [polypeptide binding]; other site 331271019377 conserved gate region; other site 331271019378 putative PBP binding loops; other site 331271019379 ABC-ATPase subunit interface; other site 331271019380 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 331271019381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019382 dimer interface [polypeptide binding]; other site 331271019383 conserved gate region; other site 331271019384 putative PBP binding loops; other site 331271019385 ABC-ATPase subunit interface; other site 331271019386 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 331271019387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271019388 Walker A/P-loop; other site 331271019389 ATP binding site [chemical binding]; other site 331271019390 Q-loop/lid; other site 331271019391 ABC transporter signature motif; other site 331271019392 Walker B; other site 331271019393 D-loop; other site 331271019394 H-loop/switch region; other site 331271019395 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271019396 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271019397 Walker A/P-loop; other site 331271019398 ATP binding site [chemical binding]; other site 331271019399 Q-loop/lid; other site 331271019400 ABC transporter signature motif; other site 331271019401 Walker B; other site 331271019402 D-loop; other site 331271019403 H-loop/switch region; other site 331271019404 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271019405 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 331271019406 Protein export membrane protein; Region: SecD_SecF; cl14618 331271019407 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 331271019408 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 331271019409 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 331271019410 Transcriptional regulators [Transcription]; Region: GntR; COG1802 331271019411 FCD domain; Region: FCD; pfam07729 331271019412 M20 Zn-peptidases include exopeptidases; Region: M20_like; cd02697 331271019413 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 331271019414 putative metal binding site [ion binding]; other site 331271019415 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 331271019416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331271019417 Walker A/P-loop; other site 331271019418 ATP binding site [chemical binding]; other site 331271019419 Q-loop/lid; other site 331271019420 ABC transporter signature motif; other site 331271019421 Walker B; other site 331271019422 D-loop; other site 331271019423 H-loop/switch region; other site 331271019424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019425 dimer interface [polypeptide binding]; other site 331271019426 conserved gate region; other site 331271019427 putative PBP binding loops; other site 331271019428 ABC-ATPase subunit interface; other site 331271019429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019430 dimer interface [polypeptide binding]; other site 331271019431 conserved gate region; other site 331271019432 putative PBP binding loops; other site 331271019433 ABC-ATPase subunit interface; other site 331271019434 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331271019435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271019436 substrate binding pocket [chemical binding]; other site 331271019437 membrane-bound complex binding site; other site 331271019438 hinge residues; other site 331271019439 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 331271019440 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 331271019441 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271019442 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271019443 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271019444 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271019445 inhibitor site; inhibition site 331271019446 active site 331271019447 dimer interface [polypeptide binding]; other site 331271019448 catalytic residue [active] 331271019449 phenylhydantoinase; Validated; Region: PRK08323 331271019450 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 331271019451 tetramer interface [polypeptide binding]; other site 331271019452 active site 331271019453 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 331271019454 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 331271019455 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331271019456 TPP-binding site [chemical binding]; other site 331271019457 dimer interface [polypeptide binding]; other site 331271019458 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331271019459 PYR/PP interface [polypeptide binding]; other site 331271019460 dimer interface [polypeptide binding]; other site 331271019461 TPP binding site [chemical binding]; other site 331271019462 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331271019463 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271019464 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271019465 trimer interface [polypeptide binding]; other site 331271019466 eyelet of channel; other site 331271019467 benzoate transport; Region: 2A0115; TIGR00895 331271019468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019470 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 331271019471 Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356 331271019472 substrate binding site [chemical binding]; other site 331271019473 Protein of unknown function (DUF521); Region: DUF521; pfam04412 331271019474 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 331271019475 substrate binding site [chemical binding]; other site 331271019476 ligand binding site [chemical binding]; other site 331271019477 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 331271019478 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 331271019479 active site 331271019480 iron coordination sites [ion binding]; other site 331271019481 substrate binding pocket [chemical binding]; other site 331271019482 benzoate transport; Region: 2A0115; TIGR00895 331271019483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019484 putative substrate translocation pore; other site 331271019485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019486 Dehydratase family; Region: ILVD_EDD; pfam00920 331271019487 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 331271019488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271019489 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 331271019490 substrate binding pocket [chemical binding]; other site 331271019491 dimerization interface [polypeptide binding]; other site 331271019492 Predicted transcriptional regulators [Transcription]; Region: COG1733 331271019493 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 331271019494 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 331271019495 NmrA-like family; Region: NmrA; pfam05368 331271019496 NADP binding site [chemical binding]; other site 331271019497 Amidohydrolase; Region: Amidohydro_2; pfam04909 331271019498 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271019499 Domain of unknown function (DUF718); Region: DUF718; pfam05336 331271019500 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331271019501 classical (c) SDRs; Region: SDR_c; cd05233 331271019502 NAD(P) binding site [chemical binding]; other site 331271019503 active site 331271019504 L-rhamnonate dehydratase; Provisional; Region: PRK15440 331271019505 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 331271019506 putative active site pocket [active] 331271019507 putative metal binding site [ion binding]; other site 331271019508 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 331271019509 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 331271019510 inhibitor site; inhibition site 331271019511 active site 331271019512 dimer interface [polypeptide binding]; other site 331271019513 catalytic residue [active] 331271019514 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 331271019515 Ligand binding site; other site 331271019516 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 331271019517 Transcriptional regulators [Transcription]; Region: GntR; COG1802 331271019518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271019519 DNA-binding site [nucleotide binding]; DNA binding site 331271019520 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 331271019521 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 331271019522 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 331271019523 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271019524 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 331271019525 homotrimer interaction site [polypeptide binding]; other site 331271019526 putative active site [active] 331271019527 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331271019528 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 331271019529 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331271019530 TM-ABC transporter signature motif; other site 331271019531 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331271019532 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331271019533 TM-ABC transporter signature motif; other site 331271019534 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331271019535 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 331271019536 Walker A/P-loop; other site 331271019537 ATP binding site [chemical binding]; other site 331271019538 Q-loop/lid; other site 331271019539 ABC transporter signature motif; other site 331271019540 Walker B; other site 331271019541 D-loop; other site 331271019542 H-loop/switch region; other site 331271019543 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331271019544 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 331271019545 Walker A/P-loop; other site 331271019546 ATP binding site [chemical binding]; other site 331271019547 Q-loop/lid; other site 331271019548 ABC transporter signature motif; other site 331271019549 Walker B; other site 331271019550 D-loop; other site 331271019551 H-loop/switch region; other site 331271019552 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 331271019553 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 331271019554 NADP binding site [chemical binding]; other site 331271019555 active site 331271019556 putative substrate binding site [chemical binding]; other site 331271019557 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331271019558 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331271019559 NAD binding site [chemical binding]; other site 331271019560 substrate binding site [chemical binding]; other site 331271019561 homodimer interface [polypeptide binding]; other site 331271019562 active site 331271019563 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 331271019564 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331271019565 putative dimer interface [polypeptide binding]; other site 331271019566 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 331271019567 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331271019568 putative dimer interface [polypeptide binding]; other site 331271019569 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 331271019570 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331271019571 PYR/PP interface [polypeptide binding]; other site 331271019572 dimer interface [polypeptide binding]; other site 331271019573 TPP binding site [chemical binding]; other site 331271019574 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331271019575 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331271019576 TPP-binding site [chemical binding]; other site 331271019577 dimer interface [polypeptide binding]; other site 331271019578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019579 D-galactonate transporter; Region: 2A0114; TIGR00893 331271019580 putative substrate translocation pore; other site 331271019581 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331271019582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271019583 NAD(P) binding site [chemical binding]; other site 331271019584 active site 331271019585 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 331271019586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271019587 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 331271019588 dimerization interface [polypeptide binding]; other site 331271019589 substrate binding pocket [chemical binding]; other site 331271019590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271019591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271019592 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 331271019593 putative dimerization interface [polypeptide binding]; other site 331271019594 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331271019595 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 331271019596 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 331271019597 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 331271019598 citrate-proton symporter; Provisional; Region: PRK15075 331271019599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019600 putative substrate translocation pore; other site 331271019601 Cache domain; Region: Cache_1; pfam02743 331271019602 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331271019603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331271019604 metal binding site [ion binding]; metal-binding site 331271019605 active site 331271019606 I-site; other site 331271019607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 331271019608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 331271019609 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 331271019610 putative effector binding pocket; other site 331271019611 dimerization interface [polypeptide binding]; other site 331271019612 NmrA-like family; Region: NmrA; pfam05368 331271019613 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 331271019614 NADP binding site [chemical binding]; other site 331271019615 active site 331271019616 regulatory binding site [polypeptide binding]; other site 331271019617 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 331271019618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271019619 Coenzyme A binding pocket [chemical binding]; other site 331271019620 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331271019621 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 331271019622 metal binding site [ion binding]; metal-binding site 331271019623 putative dimer interface [polypeptide binding]; other site 331271019624 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 331271019625 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271019626 NAD binding site [chemical binding]; other site 331271019627 catalytic residues [active] 331271019628 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271019629 hydroxyglutarate oxidase; Provisional; Region: PRK11728 331271019630 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 331271019631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271019632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271019633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271019634 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 331271019635 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331271019636 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 331271019637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271019638 Walker A/P-loop; other site 331271019639 ATP binding site [chemical binding]; other site 331271019640 Q-loop/lid; other site 331271019641 ABC transporter signature motif; other site 331271019642 Walker B; other site 331271019643 D-loop; other site 331271019644 H-loop/switch region; other site 331271019645 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331271019646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331271019647 Walker A/P-loop; other site 331271019648 ATP binding site [chemical binding]; other site 331271019649 Q-loop/lid; other site 331271019650 ABC transporter signature motif; other site 331271019651 Walker B; other site 331271019652 D-loop; other site 331271019653 H-loop/switch region; other site 331271019654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 331271019655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 331271019656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019657 dimer interface [polypeptide binding]; other site 331271019658 conserved gate region; other site 331271019659 ABC-ATPase subunit interface; other site 331271019660 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331271019661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019662 dimer interface [polypeptide binding]; other site 331271019663 conserved gate region; other site 331271019664 putative PBP binding loops; other site 331271019665 ABC-ATPase subunit interface; other site 331271019666 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331271019667 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 331271019668 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 331271019669 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271019670 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271019671 dimer interface [polypeptide binding]; other site 331271019672 putative CheW interface [polypeptide binding]; other site 331271019673 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 331271019674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331271019675 motif II; other site 331271019676 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331271019677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331271019678 Coenzyme A binding pocket [chemical binding]; other site 331271019679 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 331271019680 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 331271019681 putative ligand binding site [chemical binding]; other site 331271019682 NAD binding site [chemical binding]; other site 331271019683 dimerization interface [polypeptide binding]; other site 331271019684 catalytic site [active] 331271019685 hypothetical protein; Provisional; Region: PRK05965 331271019686 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271019687 inhibitor-cofactor binding pocket; inhibition site 331271019688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271019689 catalytic residue [active] 331271019690 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331271019691 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331271019692 putative DNA binding site [nucleotide binding]; other site 331271019693 putative Zn2+ binding site [ion binding]; other site 331271019694 AsnC family; Region: AsnC_trans_reg; pfam01037 331271019695 succinic semialdehyde dehydrogenase; Region: PLN02278 331271019696 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 331271019697 tetramerization interface [polypeptide binding]; other site 331271019698 NAD(P) binding site [chemical binding]; other site 331271019699 catalytic residues [active] 331271019700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331271019701 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 331271019702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019703 EthD domain; Region: EthD; cl17553 331271019704 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331271019705 Zn2+ binding site [ion binding]; other site 331271019706 Mg2+ binding site [ion binding]; other site 331271019707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 331271019708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 331271019709 DNA binding residues [nucleotide binding] 331271019710 dimerization interface [polypeptide binding]; other site 331271019711 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 331271019712 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271019713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019714 putative substrate translocation pore; other site 331271019715 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271019716 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 331271019717 DNA binding site [nucleotide binding] 331271019718 domain linker motif; other site 331271019719 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 331271019720 putative dimerization interface [polypeptide binding]; other site 331271019721 putative ligand binding site [chemical binding]; other site 331271019722 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 331271019723 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 331271019724 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331271019725 Cache domain; Region: Cache_1; pfam02743 331271019726 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271019727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271019728 dimer interface [polypeptide binding]; other site 331271019729 putative CheW interface [polypeptide binding]; other site 331271019730 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 331271019731 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 331271019732 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 331271019733 dimer interface [polypeptide binding]; other site 331271019734 putative CheW interface [polypeptide binding]; other site 331271019735 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 331271019736 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 331271019737 active site 331271019738 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 331271019739 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 331271019740 galactarate dehydratase; Region: galactar-dH20; TIGR03248 331271019741 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 331271019742 altronate oxidoreductase; Provisional; Region: PRK03643 331271019743 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 331271019744 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331271019745 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 331271019746 putative NAD(P) binding site [chemical binding]; other site 331271019747 catalytic Zn binding site [ion binding]; other site 331271019748 structural Zn binding site [ion binding]; other site 331271019749 Amidohydrolase; Region: Amidohydro_2; pfam04909 331271019750 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 331271019751 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331271019752 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331271019753 active site 331271019754 catalytic tetrad [active] 331271019755 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 331271019756 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 331271019757 putative ligand binding site [chemical binding]; other site 331271019758 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271019759 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271019760 TM-ABC transporter signature motif; other site 331271019761 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 331271019762 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271019763 Walker A/P-loop; other site 331271019764 ATP binding site [chemical binding]; other site 331271019765 Q-loop/lid; other site 331271019766 ABC transporter signature motif; other site 331271019767 Walker B; other site 331271019768 D-loop; other site 331271019769 H-loop/switch region; other site 331271019770 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271019771 Transcriptional regulators [Transcription]; Region: FadR; COG2186 331271019772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 331271019773 DNA-binding site [nucleotide binding]; DNA binding site 331271019774 FCD domain; Region: FCD; pfam07729 331271019775 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 331271019776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019777 putative substrate translocation pore; other site 331271019778 Helix-turn-helix domain; Region: HTH_18; pfam12833 331271019779 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 331271019780 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 331271019781 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 331271019782 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271019783 NAD(P) binding site [chemical binding]; other site 331271019784 catalytic residues [active] 331271019785 hypothetical protein; Provisional; Region: PRK07481 331271019786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331271019787 inhibitor-cofactor binding pocket; inhibition site 331271019788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331271019789 catalytic residue [active] 331271019790 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 331271019791 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271019792 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271019793 trimer interface [polypeptide binding]; other site 331271019794 eyelet of channel; other site 331271019795 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 331271019796 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 331271019797 trimer interface [polypeptide binding]; other site 331271019798 eyelet of channel; other site 331271019799 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 331271019800 Transcriptional regulator [Transcription]; Region: IclR; COG1414 331271019801 Bacterial transcriptional regulator; Region: IclR; pfam01614 331271019802 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 331271019803 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 331271019804 tetramerization interface [polypeptide binding]; other site 331271019805 NAD(P) binding site [chemical binding]; other site 331271019806 catalytic residues [active] 331271019807 NIPSNAP; Region: NIPSNAP; pfam07978 331271019808 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 331271019809 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271019810 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331271019811 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271019812 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271019813 Amino acid synthesis; Region: AA_synth; pfam06684 331271019814 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 331271019815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271019816 putative active site [active] 331271019817 putative metal binding site [ion binding]; other site 331271019818 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 331271019819 Asp-box motif; other site 331271019820 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 331271019821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331271019822 NAD(P) binding site [chemical binding]; other site 331271019823 active site 331271019824 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 331271019825 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271019826 N-terminal plug; other site 331271019827 ligand-binding site [chemical binding]; other site 331271019828 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 331271019829 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 331271019830 transmembrane helices; other site 331271019831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019832 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331271019833 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331271019834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271019835 active site 331271019836 phosphorylation site [posttranslational modification] 331271019837 intermolecular recognition site; other site 331271019838 dimerization interface [polypeptide binding]; other site 331271019839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331271019840 Walker A motif; other site 331271019841 ATP binding site [chemical binding]; other site 331271019842 Walker B motif; other site 331271019843 arginine finger; other site 331271019844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331271019845 dimer interface [polypeptide binding]; other site 331271019846 phosphorylation site [posttranslational modification] 331271019847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331271019848 ATP binding site [chemical binding]; other site 331271019849 G-X-G motif; other site 331271019850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271019851 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 331271019852 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331271019853 TM-ABC transporter signature motif; other site 331271019854 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 331271019855 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331271019856 Walker A/P-loop; other site 331271019857 ATP binding site [chemical binding]; other site 331271019858 Q-loop/lid; other site 331271019859 ABC transporter signature motif; other site 331271019860 Walker B; other site 331271019861 D-loop; other site 331271019862 H-loop/switch region; other site 331271019863 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331271019864 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 331271019865 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 331271019866 putative ligand binding site [chemical binding]; other site 331271019867 xylulokinase; Provisional; Region: PRK15027 331271019868 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 331271019869 N- and C-terminal domain interface [polypeptide binding]; other site 331271019870 active site 331271019871 MgATP binding site [chemical binding]; other site 331271019872 catalytic site [active] 331271019873 metal binding site [ion binding]; metal-binding site 331271019874 xylulose binding site [chemical binding]; other site 331271019875 homodimer interface [polypeptide binding]; other site 331271019876 xylose isomerase; Provisional; Region: PRK05474 331271019877 xylose isomerase; Region: xylose_isom_A; TIGR02630 331271019878 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 331271019879 putative dimerization interface [polypeptide binding]; other site 331271019880 putative ligand binding site [chemical binding]; other site 331271019881 Transcriptional regulators [Transcription]; Region: PurR; COG1609 331271019882 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271019883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271019884 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 331271019885 active site 331271019886 catalytic residues [active] 331271019887 Cupin; Region: Cupin_6; pfam12852 331271019888 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271019889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271019890 Uncharacterized conserved protein [Function unknown]; Region: COG2128 331271019891 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 331271019892 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 331271019893 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271019894 active site 331271019895 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271019896 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271019897 Walker A/P-loop; other site 331271019898 ATP binding site [chemical binding]; other site 331271019899 Q-loop/lid; other site 331271019900 ABC transporter signature motif; other site 331271019901 Walker B; other site 331271019902 D-loop; other site 331271019903 H-loop/switch region; other site 331271019904 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 331271019905 NMT1-like family; Region: NMT1_2; pfam13379 331271019906 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271019907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019908 dimer interface [polypeptide binding]; other site 331271019909 conserved gate region; other site 331271019910 putative PBP binding loops; other site 331271019911 ABC-ATPase subunit interface; other site 331271019912 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 331271019913 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 331271019914 Flavin binding site [chemical binding]; other site 331271019915 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 331271019916 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 331271019917 active site 331271019918 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 331271019919 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 331271019920 active site 331271019921 non-prolyl cis peptide bond; other site 331271019922 benzoate transport; Region: 2A0115; TIGR00895 331271019923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331271019924 putative substrate translocation pore; other site 331271019925 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 331271019926 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331271019927 substrate binding pocket [chemical binding]; other site 331271019928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 331271019929 membrane-bound complex binding site; other site 331271019930 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331271019931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331271019932 dimer interface [polypeptide binding]; other site 331271019933 conserved gate region; other site 331271019934 putative PBP binding loops; other site 331271019935 ABC-ATPase subunit interface; other site 331271019936 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331271019937 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 331271019938 Walker A/P-loop; other site 331271019939 ATP binding site [chemical binding]; other site 331271019940 Q-loop/lid; other site 331271019941 ABC transporter signature motif; other site 331271019942 Walker B; other site 331271019943 D-loop; other site 331271019944 H-loop/switch region; other site 331271019945 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331271019946 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331271019947 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 331271019948 transcriptional regulator MerD; Provisional; Region: PRK13749 331271019949 DNA binding residues [nucleotide binding] 331271019950 putative dimer interface [polypeptide binding]; other site 331271019951 AAA domain; Region: AAA_17; pfam13207 331271019952 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331271019953 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 331271019954 active site 331271019955 metal binding site [ion binding]; metal-binding site 331271019956 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 331271019957 trimer interface [polypeptide binding]; other site 331271019958 YadA-like C-terminal region; Region: YadA; pfam03895 331271019959 Response regulator receiver domain; Region: Response_reg; pfam00072 331271019960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331271019961 active site 331271019962 phosphorylation site [posttranslational modification] 331271019963 intermolecular recognition site; other site 331271019964 dimerization interface [polypeptide binding]; other site 331271019965 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 331271019966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 331271019967 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 331271019968 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331271019969 N-terminal plug; other site 331271019970 ligand-binding site [chemical binding]; other site 331271019971 Protein of unknown function DUF72; Region: DUF72; pfam01904 331271019972 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 331271019973 Autotransporter beta-domain; Region: Autotransporter; pfam03797